biogrid+hippie (Leiden)
Community 0
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0022626 | cytosolic ribosome | "A ribosome located in the cytosol." [GOC:mtg_sensu] | 59 | 2.788247e-103 | 0 |
| GO:CC | GO:0044391 | ribosomal subunit | "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl] | 58 | 2.788361e-85 | 0 |
| GO:CC | GO:0005840 | ribosome | "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] | 60 | 4.861737e-60 | 0 |
| GO:CC | GO:0022627 | cytosolic small ribosomal subunit | "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 28 | 2.358901e-51 | 0 |
| GO:CC | GO:0022625 | cytosolic large ribosomal subunit | "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 30 | 2.765629e-51 | 0 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 108 | 1.214220e-41 | 0 |
| GO:CC | GO:0015935 | small ribosomal subunit | "The smaller of the two subunits of a ribosome." [GOC:mah] | 28 | 1.909827e-41 | 0 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 82 | 6.853538e-40 | 0 |
| GO:CC | GO:0015934 | large ribosomal subunit | "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] | 30 | 2.000902e-39 | 0 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 112 | 6.585409e-38 | 0 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 112 | 6.690193e-38 | 0 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 42 | 1.952870e-37 | 0 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 42 | 5.226717e-37 | 0 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 102 | 5.696085e-35 | 0 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 115 | 3.455281e-33 | 0 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 71 | 3.276311e-32 | 0 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 89 | 6.426360e-32 | 0 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 105 | 3.002019e-30 | 0 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 105 | 3.002019e-30 | 0 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 105 | 3.002019e-30 | 0 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 58 | 1.777487e-28 | 0 |
| GO:CC | GO:0032040 | small-subunit processome | "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] | 20 | 5.518480e-26 | 0 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 59 | 5.526551e-24 | 0 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 42 | 6.639595e-24 | 0 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 59 | 1.158081e-23 | 0 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 59 | 1.186745e-23 | 0 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 59 | 1.186745e-23 | 0 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 115 | 2.419300e-22 | 0 |
| GO:CC | GO:0030684 | preribosome | "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] | 20 | 2.612471e-22 | 0 |
| GO:CC | GO:0005730 | nucleolus | "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] | 55 | 9.186371e-22 | 0 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 122 | 3.748489e-19 | 0 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 60 | 7.478400e-15 | 0 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 65 | 5.344699e-14 | 0 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 128 | 4.951086e-13 | 0 |
| GO:CC | GO:0014069 | postsynaptic density | "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density] | 21 | 7.242928e-13 | 0 |
| GO:CC | GO:0098984 | neuron to neuron synapse | "A synapse in which pre and post-synaptic cells are neurons." [GOC:dos] | 22 | 9.872082e-13 | 0 |
| GO:CC | GO:0032279 | asymmetric synapse | "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef] | 21 | 1.729947e-12 | 0 |
| GO:CC | GO:0099572 | postsynaptic specialization | "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028] | 21 | 5.360931e-12 | 0 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 129 | 8.436602e-12 | 0 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 63 | 1.464533e-11 | 0 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 27 | 2.263038e-11 | 0 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 17 | 6.459023e-11 | 0 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 17 | 2.046511e-10 | 0 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 130 | 3.856739e-10 | 0 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 123 | 4.513448e-09 | 0 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 117 | 1.208926e-07 | 0 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 91 | 1.994739e-06 | 0 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 9 | 1.630533e-05 | 0 |
| GO:CC | GO:0005791 | rough endoplasmic reticulum | "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] | 7 | 2.219398e-05 | 0 |
| GO:CC | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex | "A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein." [GOC:bf, GOC:PARL, PMID:12628165] | 3 | 6.414883e-05 | 0 |
| GO:CC | GO:0071013 | catalytic step 2 spliceosome | "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 7 | 3.559045e-04 | 0 |
| GO:CC | GO:0010494 | cytoplasmic stress granule | "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] | 7 | 4.125431e-04 | 0 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 9 | 4.670858e-04 | 0 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 8 | 2.539221e-03 | 0 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 28 | 3.770965e-03 | 0 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 26 | 3.885513e-03 | 0 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 17 | 6.295173e-03 | 0 |
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 8 | 1.120198e-02 | 0 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 22 | 1.140276e-02 | 0 |
| GO:CC | GO:0005662 | DNA replication factor A complex | "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] | 3 | 1.757344e-02 | 0 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 8 | 2.473964e-02 | 0 |
| GO:CC | GO:0120259 | 7SK snRNP | "A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb." [PMID:18249148, PMID:28431135] | 2 | 3.316946e-02 | 0 |
| GO:CC | GO:0000151 | ubiquitin ligase complex | "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] | 9 | 4.071610e-02 | 0 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 9 | 4.071610e-02 | 0 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 16 | 4.452070e-02 | 0 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 10 | 4.518021e-02 | 0 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 9 | 4.569921e-02 | 0 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 9 | 4.675464e-02 | 0 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-156902 | Peptide chain elongation | Peptide chain elongation | 58 | 5.921074e-94 | 0 |
| REAC | REAC:R-HSA-156842 | Eukaryotic Translation Elongation | Eukaryotic Translation Elongation | 58 | 2.994169e-92 | 0 |
| REAC | REAC:R-HSA-192823 | Viral mRNA Translation | Viral mRNA Translation | 56 | 4.645373e-89 | 0 |
| REAC | REAC:R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 57 | 4.690878e-89 | 0 |
| REAC | REAC:R-HSA-72764 | Eukaryotic Translation Termination | Eukaryotic Translation Termination | 56 | 1.873249e-87 | 0 |
| REAC | REAC:R-HSA-2408557 | Selenocysteine synthesis | Selenocysteine synthesis | 56 | 1.873249e-87 | 0 |
| REAC | REAC:R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Response of EIF2AK4 (GCN2) to amino acid deficiency | 57 | 7.482378e-87 | 0 |
| REAC | REAC:R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | L13a-mediated translational silencing of Ceruloplasmin expression | 58 | 7.881839e-86 | 0 |
| REAC | REAC:R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 58 | 1.299249e-84 | 0 |
| REAC | REAC:R-HSA-927802 | Nonsense-Mediated Decay (NMD) | Nonsense-Mediated Decay (NMD) | 58 | 1.299249e-84 | 0 |
| REAC | REAC:R-HSA-72689 | Formation of a pool of free 40S subunits | Formation of a pool of free 40S subunits | 56 | 1.499914e-84 | 0 |
| REAC | REAC:R-HSA-72737 | Cap-dependent Translation Initiation | Cap-dependent Translation Initiation | 58 | 1.868698e-83 | 0 |
| REAC | REAC:R-HSA-72613 | Eukaryotic Translation Initiation | Eukaryotic Translation Initiation | 58 | 1.868698e-83 | 0 |
| REAC | REAC:R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | GTP hydrolysis and joining of the 60S ribosomal subunit | 57 | 2.735766e-83 | 0 |
| REAC | REAC:R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | SRP-dependent cotranslational protein targeting to membrane | 56 | 4.421448e-81 | 0 |
| REAC | REAC:R-HSA-2408522 | Selenoamino acid metabolism | Selenoamino acid metabolism | 56 | 6.130831e-80 | 0 |
| REAC | REAC:R-HSA-168273 | Influenza Viral RNA Transcription and Replication | Influenza Viral RNA Transcription and Replication | 56 | 7.287101e-76 | 0 |
| REAC | REAC:R-HSA-168255 | Influenza Infection | Influenza Infection | 57 | 2.191105e-73 | 0 |
| REAC | REAC:R-HSA-9711097 | Cellular response to starvation | Cellular response to starvation | 57 | 8.420688e-73 | 0 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 58 | 3.619112e-72 | 0 |
| REAC | REAC:R-HSA-8868773 | rRNA processing in the nucleus and cytosol | rRNA processing in the nucleus and cytosol | 59 | 1.405110e-70 | 0 |
| REAC | REAC:R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Major pathway of rRNA processing in the nucleolus and cytosol | 58 | 2.678875e-70 | 0 |
| REAC | REAC:R-HSA-72312 | rRNA processing | rRNA processing | 59 | 4.613241e-69 | 0 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 58 | 3.655872e-65 | 0 |
| REAC | REAC:R-HSA-72766 | Translation | Translation | 60 | 4.041106e-60 | 0 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 75 | 6.886841e-52 | 0 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 72 | 1.667656e-51 | 0 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 75 | 2.544325e-51 | 0 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 56 | 4.465165e-48 | 0 |
| REAC | REAC:R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | SARS-CoV-1 modulates host translation machinery | 28 | 4.301631e-46 | 0 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 61 | 1.493797e-44 | 0 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 61 | 2.359399e-43 | 0 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 70 | 1.302337e-42 | 0 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 73 | 2.784574e-40 | 0 |
| REAC | REAC:R-HSA-72649 | Translation initiation complex formation | Translation initiation complex formation | 28 | 1.589858e-37 | 0 |
| REAC | REAC:R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Formation of the ternary complex, and subsequently, the 43S complex | 27 | 1.647432e-37 | 0 |
| REAC | REAC:R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 28 | 2.956011e-37 | 0 |
| REAC | REAC:R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | SARS-CoV-2 modulates host translation machinery | 26 | 9.662609e-36 | 0 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 85 | 1.063102e-35 | 0 |
| REAC | REAC:R-HSA-72702 | Ribosomal scanning and start codon recognition | Ribosomal scanning and start codon recognition | 27 | 1.573456e-35 | 0 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 30 | 7.632377e-34 | 0 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 84 | 7.859613e-31 | 0 |
| REAC | REAC:R-HSA-9678108 | SARS-CoV-1 Infection | SARS-CoV-1 Infection | 31 | 1.087797e-29 | 0 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 67 | 1.986063e-26 | 0 |
| REAC | REAC:R-HSA-9705683 | SARS-CoV-2-host interactions | SARS-CoV-2-host interactions | 28 | 6.878283e-21 | 0 |
| REAC | REAC:R-HSA-9694516 | SARS-CoV-2 Infection | SARS-CoV-2 Infection | 30 | 2.304769e-18 | 0 |
| REAC | REAC:R-HSA-9679506 | SARS-CoV Infections | SARS-CoV Infections | 34 | 1.339119e-16 | 0 |
| REAC | REAC:R-HSA-1430728 | Metabolism | Metabolism | 59 | 1.334231e-10 | 0 |
| REAC | REAC:R-HSA-3371511 | HSF1 activation | HSF1 activation | 5 | 5.340862e-05 | 0 |
| REAC | REAC:R-HSA-8876725 | Protein methylation | Protein methylation | 5 | 3.989954e-04 | 0 |
| REAC | REAC:R-HSA-9833482 | PKR-mediated signaling | PKR-mediated signaling | 8 | 7.807212e-04 | 0 |
| REAC | REAC:R-HSA-6790901 | rRNA modification in the nucleus and cytosol | rRNA modification in the nucleus and cytosol | 7 | 1.727816e-03 | 0 |
| REAC | REAC:R-HSA-3371556 | Cellular response to heat stress | Cellular response to heat stress | 8 | 2.418221e-03 | 0 |
| REAC | REAC:R-HSA-73893 | DNA Damage Bypass | DNA Damage Bypass | 6 | 6.440440e-03 | 0 |
| REAC | REAC:R-HSA-68962 | Activation of the pre-replicative complex | Activation of the pre-replicative complex | 5 | 1.326190e-02 | 0 |
| REAC | REAC:R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | Antiviral mechanism by IFN-stimulated genes | 9 | 1.709020e-02 | 0 |
| REAC | REAC:R-HSA-110320 | Translesion Synthesis by POLH | Translesion Synthesis by POLH | 4 | 2.258880e-02 | 0 |
| REAC | REAC:R-HSA-176187 | Activation of ATR in response to replication stress | Activation of ATR in response to replication stress | 5 | 2.350240e-02 | 0 |
| REAC | REAC:R-HSA-9629569 | Protein hydroxylation | Protein hydroxylation | 4 | 2.799271e-02 | 0 |
| REAC | REAC:R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | 5 | 3.049407e-02 | 0 |
| REAC | REAC:R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Regulation of TP53 Activity through Phosphorylation | 7 | 3.272611e-02 | 0 |
| REAC | REAC:R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | Regulation of HSF1-mediated heat shock response | 6 | 4.405715e-02 | 0 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002181 | cytoplasmic translation | "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] | 61 | 1.042520e-93 | 0 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 74 | 1.429587e-70 | 0 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 105 | 4.174597e-42 | 0 |
| GO:BP | GO:0042254 | ribosome biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] | 40 | 6.457201e-38 | 0 |
| GO:BP | GO:0042274 | ribosomal small subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 23 | 1.550089e-26 | 0 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 126 | 3.183673e-21 | 0 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 125 | 3.284529e-21 | 0 |
| GO:BP | GO:0016072 | rRNA metabolic process | "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] | 26 | 1.064244e-20 | 0 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 114 | 2.395960e-20 | 0 |
| GO:BP | GO:0006364 | rRNA processing | "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] | 24 | 8.214031e-20 | 0 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 111 | 1.429486e-19 | 0 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 49 | 2.910870e-16 | 0 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 114 | 5.610544e-16 | 0 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 126 | 3.729119e-14 | 0 |
| GO:BP | GO:0042255 | ribosome assembly | "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428] | 13 | 1.402182e-13 | 0 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 24 | 3.135906e-13 | 0 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 21 | 3.492100e-11 | 0 |
| GO:BP | GO:0022613 | ribonucleoprotein complex biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] | 42 | 5.368870e-11 | 0 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 70 | 1.764321e-10 | 0 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 17 | 2.167971e-10 | 0 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 31 | 2.650855e-10 | 0 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 17 | 3.041545e-10 | 0 |
| GO:BP | GO:0080135 | regulation of cellular response to stress | "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 22 | 1.689503e-09 | 0 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 54 | 2.019850e-09 | 0 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 15 | 2.414555e-09 | 0 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 56 | 5.505586e-09 | 0 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 90 | 1.942167e-08 | 0 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] | 26 | 2.098149e-08 | 0 |
| GO:BP | GO:0016032 | viral process | "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah] | 19 | 2.546752e-08 | 0 |
| GO:BP | GO:0042273 | ribosomal large subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 10 | 2.775665e-08 | 0 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 33 | 3.311647e-08 | 0 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 22 | 5.649372e-08 | 0 |
| GO:BP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 13 | 7.635627e-08 | 0 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 26 | 8.309923e-08 | 0 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 37 | 8.932056e-08 | 0 |
| GO:BP | GO:0045727 | positive regulation of translation | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] | 12 | 9.773506e-08 | 0 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 68 | 1.145806e-07 | 0 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 35 | 1.160106e-07 | 0 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 27 | 1.396126e-07 | 0 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 82 | 1.756415e-07 | 0 |
| GO:BP | GO:0043687 | post-translational protein modification | "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] | 27 | 2.264949e-07 | 0 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 27 | 2.996395e-07 | 0 |
| GO:BP | GO:0070647 | protein modification by small protein conjugation or removal | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] | 26 | 3.892856e-07 | 0 |
| GO:BP | GO:1901798 | positive regulation of signal transduction by p53 class mediator | "Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 7 | 5.197583e-07 | 0 |
| GO:BP | GO:0016567 | protein ubiquitination | "The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419] | 23 | 5.331167e-07 | 0 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 27 | 7.953448e-07 | 0 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 44 | 8.352398e-07 | 0 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 43 | 8.715851e-07 | 0 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 70 | 1.004156e-06 | 0 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 29 | 1.357583e-06 | 0 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 22 | 1.766709e-06 | 0 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 12 | 1.766755e-06 | 0 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 24 | 1.788131e-06 | 0 |
| GO:BP | GO:0010628 | positive regulation of gene expression | "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 28 | 1.828414e-06 | 0 |
| GO:BP | GO:1901796 | regulation of signal transduction by p53 class mediator | "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 10 | 1.847982e-06 | 0 |
| GO:BP | GO:0080134 | regulation of response to stress | "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 30 | 1.950621e-06 | 0 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 36 | 2.247937e-06 | 0 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 20 | 3.070548e-06 | 0 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 83 | 3.339816e-06 | 0 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 24 | 3.905233e-06 | 0 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 20 | 4.021532e-06 | 0 |
| GO:BP | GO:1903050 | regulation of proteolysis involved in protein catabolic process | "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 13 | 4.405855e-06 | 0 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 20 | 4.593541e-06 | 0 |
| GO:BP | GO:0051438 | regulation of ubiquitin-protein transferase activity | "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] | 7 | 5.262980e-06 | 0 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 26 | 6.387701e-06 | 0 |
| GO:BP | GO:0030162 | regulation of proteolysis | "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] | 16 | 7.580679e-06 | 0 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 18 | 8.421599e-06 | 0 |
| GO:BP | GO:0070925 | organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 25 | 8.494078e-06 | 0 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 70 | 1.395090e-05 | 0 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 14 | 1.458471e-05 | 0 |
| GO:BP | GO:0019079 | viral genome replication | "Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534] | 10 | 1.469161e-05 | 0 |
| GO:BP | GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 10 | 1.469161e-05 | 0 |
| GO:BP | GO:1901875 | positive regulation of post-translational protein modification | "Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 10 | 1.581335e-05 | 0 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 16 | 1.598643e-05 | 0 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 30 | 1.865911e-05 | 0 |
| GO:BP | GO:0051338 | regulation of transferase activity | "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] | 17 | 2.045753e-05 | 0 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 15 | 2.328182e-05 | 0 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 35 | 2.492120e-05 | 0 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 21 | 2.549718e-05 | 0 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 29 | 2.726919e-05 | 0 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 24 | 2.942893e-05 | 0 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 20 | 3.074575e-05 | 0 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] | 23 | 3.266998e-05 | 0 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 12 | 3.397646e-05 | 0 |
| GO:BP | GO:0006338 | chromatin remodeling | "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] | 20 | 3.448235e-05 | 0 |
| GO:BP | GO:0031398 | positive regulation of protein ubiquitination | "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 9 | 3.884988e-05 | 0 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 24 | 4.167172e-05 | 0 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 28 | 4.268135e-05 | 0 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 19 | 4.324143e-05 | 0 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 29 | 5.227155e-05 | 0 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 19 | 6.164209e-05 | 0 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 17 | 7.222910e-05 | 0 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 15 | 7.223881e-05 | 0 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 48 | 7.824806e-05 | 0 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 11 | 8.761563e-05 | 0 |
| GO:BP | GO:0000028 | ribosomal small subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl, PMID:30467428] | 5 | 1.119539e-04 | 0 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 10 | 1.257842e-04 | 0 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 10 | 1.257842e-04 | 0 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 16 | 1.381175e-04 | 0 |
| GO:BP | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 7 | 1.438864e-04 | 0 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 21 | 1.553444e-04 | 0 |
| GO:BP | GO:0006302 | double-strand break repair | "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] | 13 | 1.571785e-04 | 0 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 42 | 1.597574e-04 | 0 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 17 | 1.603437e-04 | 0 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 40 | 1.717088e-04 | 0 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 71 | 1.831798e-04 | 0 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 69 | 1.835425e-04 | 0 |
| GO:BP | GO:0006325 | chromatin organization | "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] | 21 | 1.879605e-04 | 0 |
| GO:BP | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] | 9 | 1.950922e-04 | 0 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 36 | 2.264779e-04 | 0 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 21 | 2.779772e-04 | 0 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 42 | 2.944515e-04 | 0 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 43 | 3.229929e-04 | 0 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 71 | 3.286040e-04 | 0 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 40 | 3.332276e-04 | 0 |
| GO:BP | GO:0010608 | post-transcriptional regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] | 23 | 3.518403e-04 | 0 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 22 | 4.108288e-04 | 0 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 12 | 4.426653e-04 | 0 |
| GO:BP | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 8 | 4.832641e-04 | 0 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] | 28 | 5.176825e-04 | 0 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 10 | 5.224009e-04 | 0 |
| GO:BP | GO:0000027 | ribosomal large subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428] | 5 | 5.390955e-04 | 0 |
| GO:BP | GO:0061136 | regulation of proteasomal protein catabolic process | "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb] | 10 | 6.950278e-04 | 0 |
| GO:BP | GO:0070934 | CRD-mediated mRNA stabilization | "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303] | 4 | 7.419963e-04 | 0 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 44 | 7.652750e-04 | 0 |
| GO:BP | GO:0006403 | RNA localization | "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] | 10 | 7.987323e-04 | 0 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 13 | 8.319796e-04 | 0 |
| GO:BP | GO:0044093 | positive regulation of molecular function | "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 20 | 8.448303e-04 | 0 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 31 | 8.623917e-04 | 0 |
| GO:BP | GO:0019058 | viral life cycle | "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272] | 12 | 8.687550e-04 | 0 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 41 | 8.779741e-04 | 0 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 30 | 1.027921e-03 | 0 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 71 | 1.148053e-03 | 0 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 68 | 1.429826e-03 | 0 |
| GO:BP | GO:0030490 | maturation of SSU-rRNA | "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators] | 6 | 1.499876e-03 | 0 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 24 | 1.612019e-03 | 0 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 31 | 1.746491e-03 | 0 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 16 | 1.803612e-03 | 0 |
| GO:BP | GO:0010629 | negative regulation of gene expression | "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 28 | 1.821201e-03 | 0 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 31 | 1.823174e-03 | 0 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] | 28 | 1.931508e-03 | 0 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 12 | 1.965987e-03 | 0 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 48 | 1.978700e-03 | 0 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 24 | 2.007725e-03 | 0 |
| GO:BP | GO:0006413 | translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] | 8 | 2.073916e-03 | 0 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 70 | 2.167323e-03 | 0 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 26 | 2.202360e-03 | 0 |
| GO:BP | GO:1902253 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871] | 5 | 2.454847e-03 | 0 |
| GO:BP | GO:0034063 | stress granule assembly | "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519] | 5 | 3.358603e-03 | 0 |
| GO:BP | GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 8 | 3.476218e-03 | 0 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 59 | 3.501461e-03 | 0 |
| GO:BP | GO:0006396 | RNA processing | "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] | 42 | 3.605020e-03 | 0 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 38 | 3.658899e-03 | 0 |
| GO:BP | GO:0045739 | positive regulation of DNA repair | "Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators] | 8 | 3.672814e-03 | 0 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 12 | 4.271486e-03 | 0 |
| GO:BP | GO:0000724 | double-strand break repair via homologous recombination | "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] | 9 | 4.366219e-03 | 0 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 36 | 4.562456e-03 | 0 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 47 | 5.129797e-03 | 0 |
| GO:BP | GO:0000725 | recombinational repair | "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] | 9 | 5.415887e-03 | 0 |
| GO:BP | GO:1903311 | regulation of mRNA metabolic process | "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 11 | 6.508986e-03 | 0 |
| GO:BP | GO:0010647 | positive regulation of cell communication | "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 28 | 6.619340e-03 | 0 |
| GO:BP | GO:0023056 | positive regulation of signaling | "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 28 | 6.690390e-03 | 0 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 59 | 6.817911e-03 | 0 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 27 | 7.090772e-03 | 0 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 27 | 7.248067e-03 | 0 |
| GO:BP | GO:0045898 | regulation of RNA polymerase II transcription preinitiation complex assembly | "Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators] | 3 | 7.594495e-03 | 0 |
| GO:BP | GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator | "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871] | 3 | 7.594495e-03 | 0 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 60 | 7.901262e-03 | 0 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 22 | 7.927872e-03 | 0 |
| GO:BP | GO:0034244 | negative regulation of transcription elongation by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] | 4 | 8.386883e-03 | 0 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 19 | 8.464563e-03 | 0 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 44 | 8.776401e-03 | 0 |
| GO:BP | GO:0006402 | mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 10 | 8.795600e-03 | 0 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 46 | 9.223560e-03 | 0 |
| GO:BP | GO:1904666 | regulation of ubiquitin protein ligase activity | "Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882] | 4 | 1.043346e-02 | 0 |
| GO:BP | GO:0050792 | regulation of viral process | "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:go_curators, GOC:tb] | 8 | 1.060972e-02 | 0 |
| GO:BP | GO:1901800 | positive regulation of proteasomal protein catabolic process | "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] | 7 | 1.097127e-02 | 0 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 16 | 1.162913e-02 | 0 |
| GO:BP | GO:0009896 | positive regulation of catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 14 | 1.239151e-02 | 0 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] | 11 | 1.242856e-02 | 0 |
| GO:BP | GO:0051169 | nuclear transport | "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] | 11 | 1.242856e-02 | 0 |
| GO:BP | GO:0051443 | positive regulation of ubiquitin-protein transferase activity | "Any process that activates, maintains or increases the rate of ubiquitin transferase activity." [GOC:ai, GOC:tb] | 4 | 1.282675e-02 | 0 |
| GO:BP | GO:1903573 | negative regulation of response to endoplasmic reticulum stress | "Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086] | 5 | 1.396537e-02 | 0 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 58 | 1.434899e-02 | 0 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] | 9 | 1.455711e-02 | 0 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] | 14 | 1.460558e-02 | 0 |
| GO:BP | GO:0032785 | negative regulation of DNA-templated transcription, elongation | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] | 4 | 1.560218e-02 | 0 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 15 | 1.590959e-02 | 0 |
| GO:BP | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] | 6 | 1.713079e-02 | 0 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 10 | 1.786612e-02 | 0 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 9 | 1.809993e-02 | 0 |
| GO:BP | GO:0006282 | regulation of DNA repair | "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] | 9 | 1.875672e-02 | 0 |
| GO:BP | GO:0031400 | negative regulation of protein modification process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 11 | 1.877172e-02 | 0 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 13 | 1.946732e-02 | 0 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 8 | 1.976148e-02 | 0 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] | 12 | 2.030452e-02 | 0 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 11 | 2.033314e-02 | 0 |
| GO:BP | GO:0008283 | cell population proliferation | "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] | 29 | 2.048010e-02 | 0 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 24 | 2.088429e-02 | 0 |
| GO:BP | GO:0032071 | regulation of endodeoxyribonuclease activity | "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] | 3 | 2.107251e-02 | 0 |
| GO:BP | GO:1903608 | protein localization to cytoplasmic stress granule | "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule." [GO_REF:0000087, GOC:TermGenie, PMID:24755092] | 3 | 2.107251e-02 | 0 |
| GO:BP | GO:1903747 | regulation of establishment of protein localization to mitochondrion | "Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] | 5 | 2.136973e-02 | 0 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 8 | 2.335622e-02 | 0 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 12 | 2.337398e-02 | 0 |
| GO:BP | GO:2001234 | negative regulation of apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 9 | 2.395057e-02 | 0 |
| GO:BP | GO:0043086 | negative regulation of catalytic activity | "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] | 10 | 2.413715e-02 | 0 |
| GO:BP | GO:1905897 | regulation of response to endoplasmic reticulum stress | "Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] | 6 | 2.600365e-02 | 0 |
| GO:BP | GO:0070841 | inclusion body assembly | "The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah] | 4 | 2.659614e-02 | 0 |
| GO:BP | GO:0034243 | regulation of transcription elongation by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] | 6 | 2.778940e-02 | 0 |
| GO:BP | GO:0002262 | myeloid cell homeostasis | "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] | 8 | 2.860976e-02 | 0 |
| GO:BP | GO:0040029 | epigenetic regulation of gene expression | "A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474] | 10 | 2.874426e-02 | 0 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 41 | 2.910983e-02 | 0 |
| GO:BP | GO:0017148 | negative regulation of translation | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 7 | 3.038307e-02 | 0 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 41 | 3.078380e-02 | 0 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 22 | 3.373199e-02 | 0 |
| GO:BP | GO:0048145 | regulation of fibroblast proliferation | "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] | 6 | 3.374863e-02 | 0 |
| GO:BP | GO:0034644 | cellular response to UV | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah] | 6 | 3.374863e-02 | 0 |
| GO:BP | GO:1903321 | negative regulation of protein modification by small protein conjugation or removal | "Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 6 | 3.374863e-02 | 0 |
| GO:BP | GO:0044827 | modulation by host of viral genome replication | "A process in which a host organism modulates the frequency, rate or extent of viral genome replication." [GOC:jl] | 4 | 3.654643e-02 | 0 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 23 | 3.683787e-02 | 0 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 23 | 3.724572e-02 | 0 |
| GO:BP | GO:0034599 | cellular response to oxidative stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] | 9 | 3.932492e-02 | 0 |
| GO:BP | GO:2001235 | positive regulation of apoptotic signaling pathway | "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 7 | 4.051094e-02 | 0 |
| GO:BP | GO:0034620 | cellular response to unfolded protein | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah] | 6 | 4.325369e-02 | 0 |
| GO:BP | GO:1901874 | negative regulation of post-translational protein modification | "Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 6 | 4.325369e-02 | 0 |
| GO:BP | GO:0006986 | response to unfolded protein | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] | 7 | 4.444853e-02 | 0 |
| GO:BP | GO:1904667 | negative regulation of ubiquitin protein ligase activity | "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:tb, GOC:TermGenie, PMID:26216882] | 3 | 4.474773e-02 | 0 |
| GO:BP | GO:0006401 | RNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 10 | 4.489913e-02 | 0 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 58 | 4.558813e-02 | 0 |
| GO:BP | GO:0062197 | cellular response to chemical stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] | 10 | 4.738194e-02 | 0 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP477 | Cytoplasmic ribosomal proteins | Cytoplasmic ribosomal proteins | 56 | 2.478383e-86 | 0 |
| WP | WP:WP4016 | DNA IR damage and cellular response via ATR | DNA IR damage and cellular response via ATR | 8 | 2.191855e-03 | 0 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 7 | 4.040181e-03 | 0 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 7 | 3.403961e-02 | 0 |
| WP | WP:WP466 | DNA replication | DNA replication | 5 | 4.302082e-02 | 0 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03010 | Ribosome | Ribosome | 56 | 3.213999e-72 | 0 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | Coronavirus disease - COVID-19 | 56 | 1.604034e-60 | 0 |
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 9 | 2.063872e-02 | 0 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | Ubiquitin mediated proteolysis | 8 | 2.371991e-02 | 0 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:306 | Ribosome, cytoplasmic | Ribosome, cytoplasmic | 51 | 3.816391e-63 | 0 |
| CORUM | CORUM:3055 | Nop56p-associated pre-rRNA complex | Nop56p-associated pre-rRNA complex | 48 | 5.445856e-50 | 0 |
| CORUM | CORUM:305 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 24 | 1.290289e-29 | 0 |
| CORUM | CORUM:308 | 60S ribosomal subunit, cytoplasmic | 60S ribosomal subunit, cytoplasmic | 27 | 1.391600e-29 | 0 |
| CORUM | CORUM:338 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 23 | 9.880782e-29 | 0 |
| CORUM | CORUM:5380 | TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) | TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) | 12 | 1.637535e-11 | 0 |
| CORUM | CORUM:1332 | Large Drosha complex | Large Drosha complex | 6 | 3.723048e-03 | 0 |
| CORUM | CORUM:5266 | TNF-alpha/NF-kappa B signaling complex 6 | TNF-alpha/NF-kappa B signaling complex 6 | 5 | 4.922856e-03 | 0 |
| CORUM | CORUM:6838 | IGF2BP1 complex | IGF2BP1 complex | 4 | 1.760404e-02 | 0 |
| CORUM | CORUM:3082 | DGCR8 multiprotein complex | DGCR8 multiprotein complex | 4 | 2.864812e-02 | 0 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003735 | structural constituent of ribosome | "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] | 56 | 2.522118e-55 | 0 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 95 | 1.038521e-46 | 0 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 106 | 4.367527e-36 | 0 |
| GO:MF | GO:0005198 | structural molecule activity | "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] | 57 | 1.131077e-34 | 0 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 29 | 4.275491e-20 | 0 |
| GO:MF | GO:0019843 | rRNA binding | "Binding to a ribosomal RNA." [GOC:jl] | 15 | 1.025327e-16 | 0 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 127 | 2.437653e-10 | 0 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 18 | 6.223326e-10 | 0 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 43 | 1.114224e-09 | 0 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 30 | 1.215001e-09 | 0 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 18 | 1.628856e-09 | 0 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 32 | 2.363681e-09 | 0 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 18 | 2.847689e-09 | 0 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 12 | 1.137100e-08 | 0 |
| GO:MF | GO:0048027 | mRNA 5'-UTR binding | "Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid] | 7 | 6.566915e-08 | 0 |
| GO:MF | GO:0055106 | ubiquitin-protein transferase regulator activity | "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl] | 7 | 7.726250e-07 | 0 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 29 | 1.896005e-06 | 0 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 19 | 1.952886e-06 | 0 |
| GO:MF | GO:0003684 | damaged DNA binding | "Binding to damaged DNA." [GOC:jl] | 8 | 1.652452e-05 | 0 |
| GO:MF | GO:0003727 | single-stranded RNA binding | "Binding to single-stranded RNA." [GOC:jl] | 8 | 4.018706e-05 | 0 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 19 | 8.824628e-05 | 0 |
| GO:MF | GO:1990948 | ubiquitin ligase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a ubiquitin ligase." [GOC:dph, GOC:vw, PMID:21389117] | 4 | 1.797699e-04 | 0 |
| GO:MF | GO:0003712 | transcription coregulator activity | "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] | 15 | 3.405166e-04 | 0 |
| GO:MF | GO:0003730 | mRNA 3'-UTR binding | "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] | 8 | 3.934082e-04 | 0 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 19 | 4.316666e-04 | 0 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 16 | 8.231167e-04 | 0 |
| GO:MF | GO:0055105 | ubiquitin-protein transferase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase." [GOC:BHF, GOC:rl] | 4 | 8.399829e-04 | 0 |
| GO:MF | GO:0098847 | sequence-specific single stranded DNA binding | "Binding to single-stranded DNA of a specific nucleotide composition." [PMID:9531483] | 4 | 8.399829e-04 | 0 |
| GO:MF | GO:0043021 | ribonucleoprotein complex binding | "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] | 9 | 1.020929e-03 | 0 |
| GO:MF | GO:0001098 | basal transcription machinery binding | "Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] | 6 | 1.278115e-03 | 0 |
| GO:MF | GO:0001099 | basal RNA polymerase II transcription machinery binding | "Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] | 6 | 1.278115e-03 | 0 |
| GO:MF | GO:0070180 | large ribosomal subunit rRNA binding | "Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh] | 3 | 1.392758e-03 | 0 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 16 | 2.587114e-03 | 0 |
| GO:MF | GO:1990841 | promoter-specific chromatin binding | "Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729] | 6 | 2.679515e-03 | 0 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 130 | 4.170899e-03 | 0 |
| GO:MF | GO:0001091 | RNA polymerase II general transcription initiation factor binding | "Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:txnOH, PMID:16858867] | 4 | 8.483572e-03 | 0 |
| GO:MF | GO:0097322 | 7SK snRNA binding | "Binding to a 7SK small nuclear RNA (7SK snRNA)." [GOC:nhn, PMID:21853533] | 3 | 1.148074e-02 | 0 |
| GO:MF | GO:0140296 | general transcription initiation factor binding | "Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation." [GOC:txnOH-2018] | 5 | 1.230747e-02 | 0 |
| GO:MF | GO:0008143 | poly(A) binding | "Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl] | 4 | 1.380400e-02 | 0 |
| GO:MF | GO:0098505 | G-rich strand telomeric DNA binding | "Binding to G-rich, single-stranded, telomere-associated DNA." [PMID:11349150] | 3 | 1.632401e-02 | 0 |
| GO:MF | GO:0003713 | transcription coactivator activity | "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 9 | 2.072336e-02 | 0 |
| GO:MF | GO:0140666 | annealing activity | "An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule." [PMID:22888405] | 3 | 2.234010e-02 | 0 |
| GO:MF | GO:0019903 | protein phosphatase binding | "Binding to a protein phosphatase." [GOC:jl] | 7 | 2.302691e-02 | 0 |
| GO:MF | GO:0003714 | transcription corepressor activity | "A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 8 | 2.486205e-02 | 0 |
| GO:MF | GO:0045182 | translation regulator activity | "Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai] | 5 | 2.650054e-02 | 0 |
| GO:MF | GO:0070717 | poly-purine tract binding | "Binding to a stretch of purines (adenine or guanine) in an RNA molecule." [GOC:mah] | 4 | 2.759012e-02 | 0 |
| GO:MF | GO:0043047 | single-stranded telomeric DNA binding | "Binding to single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] | 3 | 2.964696e-02 | 0 |
| GO:MF | GO:0004842 | ubiquitin-protein transferase activity | "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] | 12 | 3.787584e-02 | 0 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 11 | 3.837418e-02 | 0 |
| GO:MF | GO:0043022 | ribosome binding | "Binding to a ribosome." [GOC:go_curators] | 6 | 4.426071e-02 | 0 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0012133 | Erythroid hypoplasia | Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 18 | 2.149151e-26 | 0 |
| HP | HP:0012410 | Pure red cell aplasia | A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction. | 17 | 1.751237e-24 | 0 |
| HP | HP:0002669 | Osteosarcoma | A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor. | 18 | 1.770100e-24 | 0 |
| HP | HP:0030270 | Elevated red cell adenosine deaminase activity | Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine. | 16 | 1.083058e-23 | 0 |
| HP | HP:0031640 | Abnormal radial artery morphology | Any structural anomaly of the radial artery. | 16 | 1.083058e-23 | 0 |
| HP | HP:0020118 | Radial artery aplasia | Congenital absence of the radial artery. | 16 | 1.083058e-23 | 0 |
| HP | HP:4000209 | Abnormal erythrocyte adenosine deaminase activity | Activity of adenosine deaminase in red blood cells outside the limits of normal. | 16 | 2.640105e-23 | 0 |
| HP | HP:0005532 | Macrocytic dyserythropoietic anemia | Macrocytic dyserythropoietic anemia | 16 | 6.117807e-23 | 0 |
| HP | HP:0001227 | Abnormality of the thenar eminence | An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb. | 17 | 6.414884e-23 | 0 |
| HP | HP:0012131 | Abnormal number of erythroid precursors | A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 18 | 3.871128e-21 | 0 |
| HP | HP:0040276 | Adenocarcinoma of the colon | Adenocarcinoma of the colon | 16 | 7.778590e-21 | 0 |
| HP | HP:0006758 | Malignant genitourinary tract tumor | The presence of a malignant neoplasm of the genital system. | 16 | 1.390488e-20 | 0 |
| HP | HP:0001896 | Reticulocytopenia | A reduced number of reticulocytes in the peripheral blood. | 16 | 2.433005e-20 | 0 |
| HP | HP:0011904 | Persistence of hemoglobin F | Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent. | 16 | 2.433005e-20 | 0 |
| HP | HP:0040275 | Adenocarcinoma of the large intestine | A malignant epithelial tumor with a glandular organization that originates in the large intestine. | 16 | 7.027908e-20 | 0 |
| HP | HP:0001895 | Normochromic anemia | Normochromic anemia | 16 | 7.027908e-20 | 0 |
| HP | HP:0004808 | Acute myeloid leukemia | A form of leukemia characterized by overproduction of an early myeloid cell. | 19 | 2.080065e-19 | 0 |
| HP | HP:0009944 | Partial duplication of thumb phalanx | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 16 | 3.039267e-19 | 0 |
| HP | HP:0040273 | Adenocarcinoma of the intestines | A malignant epithelial tumor with a glandular organization that originates in the intestines. | 16 | 4.806889e-19 | 0 |
| HP | HP:0001894 | Thrombocytosis | Increased numbers of platelets in the peripheral blood. | 18 | 5.663501e-19 | 0 |
| HP | HP:0002863 | Myelodysplasia | Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia. | 21 | 6.884117e-19 | 0 |
| HP | HP:0009999 | Partial duplication of the phalanx of hand | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 16 | 7.501510e-19 | 0 |
| HP | HP:0009777 | Absent thumb | Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues. | 17 | 2.390060e-18 | 0 |
| HP | HP:0009942 | Duplication of thumb phalanx | Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits. | 17 | 4.621692e-18 | 0 |
| HP | HP:0030272 | Abnormal erythrocyte enzyme concentration or activity | An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme. | 16 | 5.821726e-18 | 0 |
| HP | HP:0006749 | Malignant gastrointestinal tract tumors | Malignant gastrointestinal tract tumors | 18 | 7.448557e-18 | 0 |
| HP | HP:0002672 | Gastrointestinal carcinoma | Gastrointestinal carcinoma | 18 | 7.448557e-18 | 0 |
| HP | HP:0005518 | Increased mean corpuscular volume | Larger than normal size of erythrocytes. | 16 | 1.764840e-17 | 0 |
| HP | HP:0000912 | Sprengel anomaly | A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other). | 16 | 3.542912e-17 | 0 |
| HP | HP:0100273 | Neoplasm of the colon | Neoplasm of the colon | 18 | 4.351406e-17 | 0 |
| HP | HP:0001199 | Triphalangeal thumb | A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb. | 17 | 8.785326e-17 | 0 |
| HP | HP:0000185 | Cleft soft palate | Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency. | 16 | 2.410118e-16 | 0 |
| HP | HP:0001972 | Macrocytic anemia | A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH). | 17 | 2.490416e-16 | 0 |
| HP | HP:0025065 | Abnormal mean corpuscular volume | A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters. | 16 | 4.342623e-16 | 0 |
| HP | HP:0100834 | Neoplasm of the large intestine | The presence of a neoplasm of the large intestine. | 19 | 1.023962e-15 | 0 |
| HP | HP:0001790 | Nonimmune hydrops fetalis | A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens . | 16 | 1.321735e-15 | 0 |
| HP | HP:0002488 | Acute leukemia | A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts). | 19 | 2.020280e-15 | 0 |
| HP | HP:0010622 | Neoplasm of the skeletal system | A tumor (abnormal growth of tissue) of the skeleton. | 18 | 5.113231e-15 | 0 |
| HP | HP:0009778 | Short thumb | Hypoplasia (congenital reduction in size) of the thumb. | 19 | 6.249703e-15 | 0 |
| HP | HP:0001909 | Leukemia | A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. | 21 | 6.590971e-15 | 0 |
| HP | HP:0004377 | Hematological neoplasm | Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). | 25 | 1.199579e-14 | 0 |
| HP | HP:0001087 | Developmental glaucoma | Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma. | 16 | 1.240862e-14 | 0 |
| HP | HP:0009380 | Finger aplasia | A developmental defect resulting in the presence of fewer than the normal number of fingers (i.e., aplasia of one or more fingers). | 17 | 1.353213e-14 | 0 |
| HP | HP:0011902 | Abnormal hemoglobin | Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes. | 16 | 1.956566e-14 | 0 |
| HP | HP:0100242 | Sarcoma | A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant. | 20 | 8.414150e-14 | 0 |
| HP | HP:0004312 | Abnormal reticulocyte morphology | A reticulocyte abnormality. | 16 | 8.705857e-14 | 0 |
| HP | HP:0009601 | Aplasia/Hypoplasia of the thumb | Hypoplastic/small or absent thumb. | 19 | 1.637647e-13 | 0 |
| HP | HP:0000294 | Low anterior hairline | Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella. | 19 | 1.862928e-13 | 0 |
| HP | HP:0001421 | Abnormality of the musculature of the hand | Abnormality of the musculature of the hand | 18 | 2.075022e-13 | 0 |
| HP | HP:0001882 | Decreased total leukocyte count | An abnormal decreased number of leukocytes in the blood. | 19 | 5.699998e-13 | 0 |
| HP | HP:0000465 | Webbed neck | Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline. | 17 | 2.662789e-12 | 0 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 21 | 3.408346e-12 | 0 |
| HP | HP:0009602 | Abnormality of thumb phalanx | A structural anomaly of one or more phalanges of the thumb. | 20 | 3.651204e-12 | 0 |
| HP | HP:0000085 | Horseshoe kidney | A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline. | 18 | 4.248611e-12 | 0 |
| HP | HP:0410030 | Cleft lip | A gap in the lip or lips. | 20 | 2.106056e-11 | 0 |
| HP | HP:0000519 | Developmental cataract | A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens. | 17 | 2.743393e-11 | 0 |
| HP | HP:0001518 | Small for gestational age | Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age. | 21 | 7.419032e-11 | 0 |
| HP | HP:0001789 | Hydrops fetalis | The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema. | 16 | 8.238510e-11 | 0 |
| HP | HP:0100736 | Abnormal soft palate morphology | An abnormality of the soft palate. | 21 | 8.605389e-11 | 0 |
| HP | HP:0001875 | Decreased total neutrophil count | Abnormal decrease of absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group. | 19 | 9.751237e-11 | 0 |
| HP | HP:0008772 | Aplasia/Hypoplasia of the external ear | The presence of aplasia or developmental hypoplasia of all or part of the external ear. | 19 | 9.751237e-11 | 0 |
| HP | HP:0001680 | Coarctation of aorta | Coarctation of the aorta is a narrowing or constriction of a segment of the aorta. | 17 | 1.087414e-10 | 0 |
| HP | HP:0100542 | Abnormal localization of kidney | An abnormal site of the kidney. | 20 | 1.119691e-10 | 0 |
| HP | HP:0000782 | Abnormal scapula morphology | Any abnormality of the scapula, also known as the shoulder blade. | 18 | 1.196515e-10 | 0 |
| HP | HP:0011792 | Neoplasm by histology | Neoplasm categorized according to type of histological abnormality. | 23 | 1.699056e-10 | 0 |
| HP | HP:0008771 | Aplasia/Hypoplasia of the ear | The presence of aplasia or developmental hypoplasia of the ear. | 19 | 1.790621e-10 | 0 |
| HP | HP:0000599 | Abnormality of the frontal hairline | An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not. | 19 | 2.121514e-10 | 0 |
| HP | HP:0034930 | Digestive system neoplasm | A tumor (abnormal growth of tissue) of the digestive system. | 23 | 2.162025e-10 | 0 |
| HP | HP:0008551 | Microtia | Underdevelopment of the external ear. | 18 | 3.068836e-10 | 0 |
| HP | HP:0011991 | Abnormal total neutrophil count | A deviation from the normal range of neutrophil cell counts in the circulation. | 19 | 4.827803e-10 | 0 |
| HP | HP:0010972 | Anemia of inadequate production | A kind of anemia characterized by inadequate production of erythrocytes. | 18 | 6.840430e-10 | 0 |
| HP | HP:0001874 | Abnormality of neutrophils | A neutrophil abnormality. | 20 | 7.348020e-10 | 0 |
| HP | HP:0032309 | Abnormal granulocyte count | Abnormal increase or decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group. | 20 | 9.745750e-10 | 0 |
| HP | HP:0001911 | Abnormal granulocyte morphology | Any structural abnormality or abnormal count of granulocytes. | 21 | 1.697104e-09 | 0 |
| HP | HP:0001172 | Abnormal thumb morphology | An abnormal structure of the first digit of the hand. | 23 | 1.753430e-09 | 0 |
| HP | HP:0000980 | Pallor | Abnormally pale skin. | 16 | 1.971443e-09 | 0 |
| HP | HP:0002664 | Neoplasm | An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor). | 33 | 5.119587e-09 | 0 |
| HP | HP:0009553 | Abnormality of the hairline | The hairline refers to the outline of hair of the head. An abnormality of the hairline can refer to an unusually low or high border between areas of the scalp with and without hair or to abnormal projections of scalp hair. | 20 | 5.480088e-09 | 0 |
| HP | HP:0007378 | Neoplasm of the gastrointestinal tract | A tumor (abnormal growth of tissue) of the gastrointestinal tract. | 20 | 5.836021e-09 | 0 |
| HP | HP:0009997 | Duplication of phalanx of hand | This term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated. | 18 | 7.033150e-09 | 0 |
| HP | HP:0004275 | Duplication of hand bones | Duplication of hand bones | 18 | 8.157125e-09 | 0 |
| HP | HP:0009142 | Duplication of bones involving the upper extremities | Duplication of bones involving the upper extremities | 18 | 8.157125e-09 | 0 |
| HP | HP:0010974 | Abnormal myeloid leukocyte morphology | An abnormality of myeloid leukocytes. | 21 | 8.435330e-09 | 0 |
| HP | HP:0034058 | Abnormal fetal morphology | Any structural anomaly of the fetus. | 20 | 1.374112e-08 | 0 |
| HP | HP:0011793 | Neoplasm by anatomical site | Neoplasm categorized according to the anatomical site of origin of the neoplasm. | 32 | 1.720791e-08 | 0 |
| HP | HP:0011361 | Congenital abnormal hair pattern | A congenital abnormality of the distribution of hair growth. | 20 | 3.278950e-08 | 0 |
| HP | HP:0011893 | Abnormal leukocyte count | Number of leukocytes per volume of blood beyond normal limits. | 24 | 4.077355e-08 | 0 |
| HP | HP:0010720 | Abnormal hair pattern | An abnormality of the distribution of hair growth. | 21 | 4.964620e-08 | 0 |
| HP | HP:0100037 | Abnormality of the scalp hair | An abnormality of the hair of head. | 22 | 1.008786e-07 | 0 |
| HP | HP:0100627 | Displacement of the urethral meatus | A displacement of the external urethral orifice from its normal position (in males normally placed at the tip of glans penis, in females normally placed about 2.5 cm behind the glans clitoridis and immediately in front of that of the vagina). | 21 | 1.467493e-07 | 0 |
| HP | HP:0032076 | Abnormal male urethral meatus morphology | Abnormal male urethral meatus morphology | 21 | 1.613787e-07 | 0 |
| HP | HP:0000104 | Renal agenesis | Agenesis, that is, failure of the kidney to develop during embryogenesis and development. | 16 | 1.846472e-07 | 0 |
| HP | HP:0001965 | Abnormal scalp morphology | Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows. | 22 | 2.148577e-07 | 0 |
| HP | HP:0001446 | Abnormality of the musculature of the upper limbs | Abnormality of the musculature of the upper limbs | 18 | 2.619256e-07 | 0 |
| HP | HP:0009381 | Short finger | Abnormally short finger associated with developmental hypoplasia. | 19 | 2.683036e-07 | 0 |
| HP | HP:0000175 | Cleft palate | Cleft palate is a developmental defect of the palate resulting from a failure of fusion of the palatine processes and manifesting as a separation of the roof of the mouth (soft and hard palate). | 25 | 3.126258e-07 | 0 |
| HP | HP:0007700 | Ocular anterior segment dysgenesis | Abnormal development (dysgenesis) of the anterior segment of the eye globe. These structures are mainly of mesenchymal origin. | 19 | 3.146422e-07 | 0 |
| HP | HP:0006265 | Aplasia/Hypoplasia of fingers | Small/hypoplastic or absent/aplastic fingers. | 20 | 3.289564e-07 | 0 |
| HP | HP:0000286 | Epicanthus | A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus. | 25 | 4.295911e-07 | 0 |
| HP | HP:0000047 | Hypospadias | Abnormal position of urethral meatus on the ventral penile shaft (underside) characterized by displacement of the urethral meatus from the tip of the glans penis to the ventral surface of the penis, scrotum, or perineum. | 20 | 4.833398e-07 | 0 |
| HP | HP:0000002 | Abnormality of body height | Deviation from the norm of height with respect to that which is expected according to age and gender norms. | 38 | 4.940118e-07 | 0 |
| HP | HP:0010987 | Abnormal cellular immune system morphology | An abnormality of the morphology or counts of the cells that make up the immune system. | 25 | 7.713793e-07 | 0 |
| HP | HP:0001881 | Abnormal leukocyte morphology | An abnormality of leukocytes. | 25 | 7.713793e-07 | 0 |
| HP | HP:0002250 | Abnormal large intestine morphology | Any abnormality of the large intestine. | 21 | 1.097388e-06 | 0 |
| HP | HP:0004322 | Short stature | A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to \"short stature\" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms). | 36 | 1.242658e-06 | 0 |
| HP | HP:0000202 | Orofacial cleft | The presence of a cleft (gap, opening, or groove) in the oral cavity, including cleft of the upper lip and/or cleft of the palate. Cleft of the upper lip is visible as a groove or fissure in the lip, most frequently due to a congenital failure of the maxillary and median nasal processes to fuse. Cleft palate is characterized by a grooved depression or fissure in the roof of the mouth, most often resulting from a congenital failure of the palate to fuse properly. Clefts of the lip and palate can occur individually or together. It is preferable to code each defect separately. | 25 | 1.315482e-06 | 0 |
| HP | HP:0000470 | Short neck | Diminished length of the neck. | 20 | 1.388052e-06 | 0 |
| HP | HP:5201015 | Craniofacial cleft | Congenital abnormality with cleft (gap or opening) in the craniofacial bones. Craniofacial cleft includes facial cleft, orofacial clef, and cleft of the jaw. | 25 | 1.549190e-06 | 0 |
| HP | HP:0032251 | Abnormal immune system morphology | Abnormal immune system morphology | 25 | 1.881303e-06 | 0 |
| HP | HP:0011873 | Abnormal platelet count | Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood. | 21 | 1.953591e-06 | 0 |
| HP | HP:0011875 | Abnormal platelet morphology | An anomaly in platelet form, ultrastructure, or intracellular organelles. | 21 | 2.294612e-06 | 0 |
| HP | HP:0001254 | Lethargy | A state of fatigue, either physical or mental slowness and sluggishness, with difficulties in initiating or performing simple tasks. Distinguished from apathy which implies indifference and a lack of desire or interest in the task. A person with lethargy may have the desire, but not the energy to engage in personal or socially relevant tasks. | 16 | 2.404312e-06 | 0 |
| HP | HP:0000795 | Abnormality of the urethra | An abnormality of the urethra, i.e., of the tube which connects the urinary bladder to the outside of the body. | 21 | 2.799200e-06 | 0 |
| HP | HP:0010936 | Abnormality of the lower urinary tract | An abnormality of the lower urinary tract. | 28 | 3.694750e-06 | 0 |
| HP | HP:0001903 | Anemia | A reduction in erythrocytes volume or hemoglobin concentration. | 24 | 4.536208e-06 | 0 |
| HP | HP:0001872 | Abnormality of thrombocytes | An abnormality of platelets. | 21 | 6.276877e-06 | 0 |
| HP | HP:0009127 | Abnormality of the musculature of the limbs | Abnormality of the musculature of the limbs | 24 | 7.074177e-06 | 0 |
| HP | HP:0003319 | Abnormality of the cervical spine | Any abnormality of the cervical vertebral column. | 20 | 7.698090e-06 | 0 |
| HP | HP:0000745 | Abnormal diminished volition | A reduction in willful and motivated goal-directed behavior that is considered the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action. | 24 | 1.057549e-05 | 0 |
| HP | HP:0000218 | High palate | Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective). | 26 | 1.474520e-05 | 0 |
| HP | HP:0000036 | Abnormal penis morphology | Abnormality of the male external sex organ. | 24 | 1.870494e-05 | 0 |
| HP | HP:0000501 | Glaucoma | Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure. | 18 | 2.338381e-05 | 0 |
| HP | HP:0001873 | Thrombocytopenia | A reduction in the number of circulating thrombocytes. | 19 | 2.427142e-05 | 0 |
| HP | HP:0001877 | Abnormal erythrocyte morphology | Any structural abnormality of erythrocytes (red-blood cells). | 24 | 3.063977e-05 | 0 |
| HP | HP:0005927 | Aplasia/hypoplasia involving bones of the hand | Absence (due to failure to form) or underdevelopment of the bones of the hand. | 21 | 3.781410e-05 | 0 |
| HP | HP:0000369 | Low-set ears | Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear. | 25 | 4.212313e-05 | 0 |
| HP | HP:0004325 | Decreased body weight | Abnormally low body weight. | 36 | 5.120995e-05 | 0 |
| HP | HP:0025780 | Abnormal volitional state | An abnormality of internal states of motivation or drive that compromise, or interfere with, the ability of the person to attend to basic personal, social, or vocational activities. | 31 | 5.539504e-05 | 0 |
| HP | HP:0011024 | Abnormality of the gastrointestinal tract | An abnormality of the gastrointestinal tract. | 38 | 5.690355e-05 | 0 |
| HP | HP:0000347 | Micrognathia | Developmental hypoplasia of the mandible. | 26 | 5.888395e-05 | 0 |
| HP | HP:0009118 | Aplasia/Hypoplasia of the mandible | Absence or underdevelopment of the mandible. | 26 | 6.190580e-05 | 0 |
| HP | HP:0025668 | Abnormal neck morphology | Any structural anomaly of the neck region. | 23 | 6.597282e-05 | 0 |
| HP | HP:0008678 | Renal hypoplasia/aplasia | Absence or underdevelopment of the kidney. | 17 | 7.476803e-05 | 0 |
| HP | HP:0009116 | Aplasia/Hypoplasia involving bones of the skull | Aplasia/Hypoplasia involving bones of the skull | 26 | 7.739558e-05 | 0 |
| HP | HP:0000006 | Autosomal dominant inheritance | A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele. | 40 | 8.070963e-05 | 0 |
| HP | HP:0001679 | Abnormal aortic morphology | An abnormality of the aorta. | 18 | 8.087088e-05 | 0 |
| HP | HP:0005280 | Depressed nasal bridge | Posterior positioning of the nasal root in relation to the overall facial profile for age. | 22 | 9.010727e-05 | 0 |
| HP | HP:0005918 | Abnormal finger phalanx morphology | Abnormalities affecting the phalanx of finger. | 23 | 9.259751e-05 | 0 |
| HP | HP:0000431 | Wide nasal bridge | Increased breadth of the nasal bridge (and with it, the nasal root). | 20 | 9.897706e-05 | 0 |
| HP | HP:0002060 | Abnormal cerebral morphology | Any structural abnormality of the telencephalon, which is also known as the cerebrum. | 41 | 9.906064e-05 | 0 |
| HP | HP:0006496 | Aplasia/hypoplasia involving bones of the upper limbs | Absence (due to failure to form) or underdevelopment of the bones of the upper limbs. | 21 | 1.152496e-04 | 0 |
| HP | HP:0034057 | Fetal anomaly | Structural or functional abnormalities of the fetus. Note that this section comprises terms that describe abnormalities that are specific to the fetus or differ from the corresponding general terms. A term from anywhere in the Human Phenotype Ontology can be applied to a fetus if appropriate. | 21 | 1.301902e-04 | 0 |
| HP | HP:0002242 | Abnormal intestine morphology | An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine. | 24 | 1.369542e-04 | 0 |
| HP | HP:0002977 | Aplasia/Hypoplasia involving the central nervous system | Absence or underdevelopment of tissue in the central nervous system. | 39 | 1.377048e-04 | 0 |
| HP | HP:0012243 | Abnormal reproductive system morphology | A structural or developmental anomaly of any of the tissues involved in the genital system. | 33 | 1.420309e-04 | 0 |
| HP | HP:0000159 | Abnormal lip morphology | An abnormality of the lip. | 31 | 1.564444e-04 | 0 |
| HP | HP:0100547 | Abnormal forebrain morphology | An abnormality of the forebrain, which has as its parts the telencephalon, diencephalon, lateral ventricles and third ventricle. | 41 | 1.618281e-04 | 0 |
| HP | HP:0000032 | Abnormal male external genitalia morphology | Any structural abnormality of male external genitalia. | 29 | 1.886343e-04 | 0 |
| HP | HP:0000316 | Hypertelorism | Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes). | 25 | 2.242372e-04 | 0 |
| HP | HP:0001631 | Atrial septal defect | Atrial septal defect (ASD) is a congenital abnormality of the interatrial septum that enables blood flow between the left and right atria via the interatrial septum. | 20 | 2.408785e-04 | 0 |
| HP | HP:0000464 | Abnormality of the neck | An abnormality of the neck. | 23 | 2.513727e-04 | 0 |
| HP | HP:0011994 | Abnormal atrial septum morphology | An abnormality of the interatrial septum. | 20 | 2.722210e-04 | 0 |
| HP | HP:0001595 | Abnormal hair morphology | An abnormality of the hair. | 32 | 2.809332e-04 | 0 |
| HP | HP:0000252 | Microcephaly | Head circumference below 2 standard deviations below the mean for age and gender. | 32 | 2.862048e-04 | 0 |
| HP | HP:0009815 | Aplasia/hypoplasia of the extremities | Absence (due to failure to form) or underdevelopment of the extremities. | 23 | 3.092321e-04 | 0 |
| HP | HP:0034684 | Abnormal enzyme concentration or activity | Concentration or activity of an enzyme is above or below the limits of normal. | 23 | 3.514446e-04 | 0 |
| HP | HP:0000549 | Abnormal conjugate eye movement | Any deviation from the normal motor coordination of the eyes that allows for bilateral fixation on a single object. | 30 | 3.540592e-04 | 0 |
| HP | HP:0040195 | Decreased head circumference | An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean. | 32 | 3.638169e-04 | 0 |
| HP | HP:0011927 | Short digit | One or more digit that appears disproportionately short compared to the hand/foot, whereby either the entire digit or a specific phalanx is shortened. | 21 | 3.723385e-04 | 0 |
| HP | HP:0000811 | Abnormal external genitalia morphology | A structural anomaly of the external genitalia. | 29 | 4.703346e-04 | 0 |
| HP | HP:0045060 | Aplasia/hypoplasia involving bones of the extremities | Aplasia/hypoplasia involving bones of the extremities | 22 | 4.894828e-04 | 0 |
| HP | HP:0010461 | Abnormality of the male genitalia | Abnormality of the male genital system. | 29 | 5.190048e-04 | 0 |
| HP | HP:0000518 | Cataract | A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule. | 24 | 6.450279e-04 | 0 |
| HP | HP:0000925 | Abnormality of the vertebral column | Any abnormality of the vertebral column. | 34 | 6.638802e-04 | 0 |
| HP | HP:0000357 | Abnormal location of ears | Abnormal location of the ear. | 26 | 7.320576e-04 | 0 |
| HP | HP:0000508 | Ptosis | The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective). | 23 | 7.397405e-04 | 0 |
| HP | HP:0009122 | Aplasia/hypoplasia affecting bones of the axial skeleton | Absence (due to failure to form) or underdevelopment of bones of the axial skeleton. | 26 | 7.970608e-04 | 0 |
| HP | HP:0012718 | Abnormal gastrointestinal tract morphology | Abnormal structure of the gastrointestinal tract. | 26 | 8.141325e-04 | 0 |
| HP | HP:0000517 | Abnormal lens morphology | An abnormality of the lens. | 24 | 9.323863e-04 | 0 |
| HP | HP:0030791 | Abnormal jaw morphology | A structural anomaly of the jaw, the bony structure of the mouth that consists of the mandible and the maxilla. | 29 | 9.613363e-04 | 0 |
| HP | HP:0025766 | Abnormal affect | An anomaly in intensity, frequency, or duration of the verbal or behavioral expression of emotions, feelings, or thoughts. | 31 | 9.666341e-04 | 0 |
| HP | HP:0001671 | Abnormal cardiac septum morphology | An anomaly of the intra-atrial or intraventricular septum. | 23 | 1.217352e-03 | 0 |
| HP | HP:0000277 | Abnormal mandible morphology | Any abnormality of the mandible, the bone of the lower jaw. | 28 | 1.359150e-03 | 0 |
| HP | HP:0011004 | Abnormal systemic arterial morphology | An abnormality of the systemic arterial tree, which consists of the aorta and other systemic arteries. | 19 | 1.473932e-03 | 0 |
| HP | HP:0000163 | Abnormal oral cavity morphology | Abnormality of the oral cavity, i.e., the opening or hollow part of the mouth. | 41 | 1.793761e-03 | 0 |
| HP | HP:0031816 | Abnormal oral morphology | Any structural anomaly of the mouth, which is also known as the oral cavity. | 41 | 1.793761e-03 | 0 |
| HP | HP:0005922 | Abnormal hand morphology | Any structural anomaly of the hand. | 27 | 1.844440e-03 | 0 |
| HP | HP:0005120 | Abnormal cardiac atrium morphology | Any structural abnormality of a cardiac atrium. | 20 | 1.903312e-03 | 0 |
| HP | HP:0001510 | Growth delay | A deficiency or slowing down of growth pre- and postnatally. | 37 | 2.024472e-03 | 0 |
| HP | HP:0000969 | Edema | An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body. | 21 | 2.056202e-03 | 0 |
| HP | HP:0000377 | Abnormal pinna morphology | An abnormality of the pinna, which is also referred to as the auricle or external ear. | 30 | 2.269514e-03 | 0 |
| HP | HP:0004323 | Abnormality of body weight | An abnormal increase or decrease of weight or an abnormal distribution of mass in the body. | 36 | 2.594345e-03 | 0 |
| HP | HP:0000174 | Abnormal palate morphology | Any abnormality of the palate, i.e., of roof of the mouth. | 28 | 2.660973e-03 | 0 |
| HP | HP:0001629 | Ventricular septal defect | A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum. | 18 | 2.740830e-03 | 0 |
| HP | HP:0000356 | Abnormality of the outer ear | An abnormality of the external ear. | 30 | 2.889055e-03 | 0 |
| HP | HP:0000422 | Abnormal nasal bridge morphology | Abnormality of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi. | 26 | 3.606548e-03 | 0 |
| HP | HP:0010438 | Abnormal ventricular septum morphology | A structural abnormality of the interventricular septum. | 18 | 3.732277e-03 | 0 |
| HP | HP:0000366 | Abnormality of the nose | An abnormality of the nose. | 35 | 3.758616e-03 | 0 |
| HP | HP:0025033 | Abnormal digestive system morphology | A structural anomaly of the digestive system. | 26 | 4.198412e-03 | 0 |
| HP | HP:0011138 | Abnormal skin adnexa morphology | An abnormality of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands. | 32 | 4.377834e-03 | 0 |
| HP | HP:0007364 | Aplasia/Hypoplasia of the cerebrum | Aplasia/Hypoplasia of the cerebrum | 33 | 5.099906e-03 | 0 |
| HP | HP:0011844 | Abnormal appendicular skeleton morphology | An abnormality of the appendicular skeletal system, consisting of the of the limbs, shoulder and pelvic girdles. | 36 | 5.885555e-03 | 0 |
| HP | HP:0000078 | Abnormality of the genital system | An abnormality of the genital system. | 34 | 6.073353e-03 | 0 |
| HP | HP:0000153 | Abnormality of the mouth | An abnormality of the mouth. | 41 | 6.126565e-03 | 0 |
| HP | HP:0000240 | Abnormality of skull size | Any abnormality of the size of the skull. | 33 | 7.903176e-03 | 0 |
| HP | HP:0001167 | Abnormal finger morphology | An anomaly of a finger. | 28 | 8.323911e-03 | 0 |
| HP | HP:0011821 | Abnormal facial skeleton morphology | An abnormality of one or more of the set of bones that make up the facial skeleton. | 30 | 9.295146e-03 | 0 |
| HP | HP:0000492 | Abnormal eyelid morphology | An abnormality of the eyelids. | 30 | 9.295146e-03 | 0 |
| HP | HP:0030962 | Abnormal morphology of the great vessels | A structural anomaly affecting a blood vessel involved in the circulation of the heart, i.e., the superior or inferior vena cava, the pulmonary arteries, the pulmonary veins, and the aorta. | 21 | 9.451374e-03 | 0 |
| HP | HP:0000486 | Strabismus | A misalignment of the eyes so that the visual axes deviate from bifoveal fixation. The classification of strabismus may be based on a number of features including the relative position of the eyes, whether the deviation is latent or manifest, intermittent or constant, concomitant or otherwise and according to the age of onset and the relevance of any associated refractive error. | 27 | 1.092961e-02 | 0 |
| HP | HP:0001442 | Typified by somatic mosaicism | Description of conditions in which affected individuals typically display somatic mosaicism, i.e., genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations. In many conditions typified by somatic mosaicism, constitutive mutation is lethal and cases are exclusively or predominantly mosaic. | 10 | 1.198023e-02 | 0 |
| HP | HP:0002813 | Abnormal limb bone morphology | Any abnormality of bones of the arms or legs. | 34 | 1.289932e-02 | 0 |
| HP | HP:0040068 | Abnormality of limb bone | Abnormality of limb bone | 34 | 1.289932e-02 | 0 |
| HP | HP:0001507 | Growth abnormality | Growth abnormality | 43 | 1.428237e-02 | 0 |
| HP | HP:0005105 | Abnormal nasal morphology | Abnormal nasal morphology | 31 | 1.523636e-02 | 0 |
| HP | HP:0011032 | Abnormality of fluid regulation | An abnormality of the regulation of body fluids. | 21 | 1.572994e-02 | 0 |
| HP | HP:0001155 | Abnormality of the hand | An abnormality affecting one or both hands. | 32 | 1.637054e-02 | 0 |
| HP | HP:0012443 | Abnormal brain morphology | A structural abnormality of the brain, which has as its parts the forebrain, midbrain, and hindbrain. | 43 | 1.807020e-02 | 0 |
| HP | HP:0100886 | Abnormality of globe location | An abnormality in the placement of the ocular globe (eyeball). | 26 | 1.946503e-02 | 0 |
| HP | HP:0030669 | Abnormal ocular adnexa morphology | A structural anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. | 32 | 2.003308e-02 | 0 |
| HP | HP:0000290 | Abnormal forehead morphology | An anomaly of the forehead. | 27 | 2.266900e-02 | 0 |
| HP | HP:0000765 | Abnormal thorax morphology | Any abnormality of the thorax (the region of the body formed by the sternum, the thoracic vertebrae and the ribs). | 23 | 2.401978e-02 | 0 |
| HP | HP:0032039 | Abnormality of the ocular adnexa | An anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. | 32 | 2.736113e-02 | 0 |
| HP | HP:0009115 | Aplasia/hypoplasia involving the skeleton | Absence (due to failure to form) or underdevelopment of one or more components of the skeleton. | 27 | 3.068682e-02 | 0 |
| HP | HP:0000315 | Abnormality of the orbital region | Abnormality of the orbital region | 32 | 3.975239e-02 | 0 |
| HP | HP:0002817 | Abnormality of the upper limb | An abnormality of the arm. | 33 | 4.064365e-02 | 0 |
| HP | HP:0001871 | Abnormality of blood and blood-forming tissues | An abnormality of the hematopoietic system. | 30 | 4.603550e-02 | 0 |
| HP | HP:0001197 | Abnormality of prenatal development or birth | An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities. | 24 | 4.960752e-02 | 0 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 66 | 4.468109e-20 | 0 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 52 | 3.254825e-18 | 0 |
| HPA | HPA:0090163 | Cerebellum; Purkinje cells[High] | Cerebellum; Purkinje cells[High] | 56 | 2.794935e-17 | 0 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 57 | 1.006887e-16 | 0 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 59 | 7.056192e-16 | 0 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 82 | 3.906049e-15 | 0 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 49 | 1.794276e-14 | 0 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 86 | 2.632957e-14 | 0 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 43 | 2.648315e-14 | 0 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 45 | 4.068036e-14 | 0 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 87 | 4.408056e-14 | 0 |
| HPA | HPA:0620000 | Vagina | Vagina | 101 | 4.547587e-14 | 0 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 101 | 4.547587e-14 | 0 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 83 | 3.171518e-13 | 0 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 49 | 5.961896e-13 | 0 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 54 | 9.019412e-13 | 0 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 82 | 2.178269e-12 | 0 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 67 | 2.381126e-12 | 0 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 90 | 2.815888e-12 | 0 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 82 | 2.946601e-12 | 0 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 84 | 4.299483e-12 | 0 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 76 | 4.347106e-12 | 0 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 42 | 4.816325e-12 | 0 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 91 | 5.908460e-12 | 0 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 75 | 6.186498e-12 | 0 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 41 | 9.165430e-12 | 0 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 107 | 9.816602e-12 | 0 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 107 | 9.816602e-12 | 0 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 98 | 1.154717e-11 | 0 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 33 | 1.279567e-11 | 0 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 43 | 1.315158e-11 | 0 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 34 | 1.390946e-11 | 0 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 90 | 1.445560e-11 | 0 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 90 | 1.445560e-11 | 0 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 99 | 4.689324e-11 | 0 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 44 | 4.797109e-11 | 0 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 46 | 4.955894e-11 | 0 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 99 | 7.190347e-11 | 0 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 99 | 7.190347e-11 | 0 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 79 | 8.179648e-11 | 0 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 32 | 9.705320e-11 | 0 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 57 | 1.190407e-10 | 0 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 87 | 1.349174e-10 | 0 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 109 | 1.562954e-10 | 0 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 109 | 2.080917e-10 | 0 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 96 | 2.183856e-10 | 0 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 103 | 2.223039e-10 | 0 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 103 | 2.223039e-10 | 0 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 70 | 2.285362e-10 | 0 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 33 | 2.406388e-10 | 0 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 28 | 2.484078e-10 | 0 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 86 | 3.009773e-10 | 0 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 45 | 3.407439e-10 | 0 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 30 | 4.464835e-10 | 0 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 59 | 4.562504e-10 | 0 |
| HPA | HPA:0400000 | Rectum | Rectum | 109 | 5.341049e-10 | 0 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 87 | 5.346941e-10 | 0 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 91 | 7.278640e-10 | 0 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 106 | 8.024463e-10 | 0 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 30 | 9.921383e-10 | 0 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 35 | 1.285069e-09 | 0 |
| HPA | HPA:0630000 | Cervix | Cervix | 102 | 1.881569e-09 | 0 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 76 | 2.119798e-09 | 0 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 31 | 2.302281e-09 | 0 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 102 | 2.354831e-09 | 0 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 99 | 2.395928e-09 | 0 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 30 | 2.948149e-09 | 0 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 33 | 3.639947e-09 | 0 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 57 | 4.384739e-09 | 0 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 107 | 5.357755e-09 | 0 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 27 | 6.351379e-09 | 0 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 102 | 7.223134e-09 | 0 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 102 | 9.554717e-09 | 0 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 99 | 1.035986e-08 | 0 |
| HPA | HPA:0380000 | Placenta | Placenta | 105 | 1.049074e-08 | 0 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 31 | 1.087707e-08 | 0 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 26 | 1.214489e-08 | 0 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 87 | 1.309088e-08 | 0 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 33 | 1.540348e-08 | 0 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 17 | 1.550723e-08 | 0 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 104 | 1.822130e-08 | 0 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 86 | 1.852693e-08 | 0 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 72 | 1.921606e-08 | 0 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 45 | 2.070424e-08 | 0 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 34 | 2.171293e-08 | 0 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 26 | 2.173075e-08 | 0 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 29 | 2.322972e-08 | 0 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 99 | 2.551938e-08 | 0 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 83 | 2.852319e-08 | 0 |
| HPA | HPA:0290401 | Liver; hepatocytes[≥Low] | Liver; hepatocytes[≥Low] | 91 | 2.901752e-08 | 0 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 96 | 2.982798e-08 | 0 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 32 | 3.001772e-08 | 0 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 87 | 3.085257e-08 | 0 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 27 | 3.500004e-08 | 0 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 31 | 3.620426e-08 | 0 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 97 | 3.865616e-08 | 0 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 97 | 3.865616e-08 | 0 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 50 | 4.038182e-08 | 0 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 59 | 4.224744e-08 | 0 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 75 | 4.505906e-08 | 0 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 27 | 4.800109e-08 | 0 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 100 | 5.111509e-08 | 0 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 33 | 5.172380e-08 | 0 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 90 | 5.706166e-08 | 0 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 95 | 5.782161e-08 | 0 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 94 | 5.975925e-08 | 0 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 98 | 6.662933e-08 | 0 |
| HPA | HPA:0390000 | Prostate | Prostate | 98 | 6.662933e-08 | 0 |
| HPA | HPA:0290000 | Liver | Liver | 95 | 6.736077e-08 | 0 |
| HPA | HPA:0030000 | Appendix | Appendix | 106 | 6.852418e-08 | 0 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 98 | 6.981509e-08 | 0 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 98 | 6.981509e-08 | 0 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 99 | 7.719769e-08 | 0 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 76 | 8.497394e-08 | 0 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 78 | 8.621111e-08 | 0 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 99 | 8.671589e-08 | 0 |
| HPA | HPA:0080000 | Caudate | Caudate | 100 | 8.848439e-08 | 0 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 28 | 1.047005e-07 | 0 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 86 | 1.091301e-07 | 0 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 25 | 1.101335e-07 | 0 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 80 | 1.129345e-07 | 0 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 31 | 1.155291e-07 | 0 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 41 | 1.263844e-07 | 0 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 31 | 1.292502e-07 | 0 |
| HPA | HPA:0530000 | Spleen | Spleen | 91 | 1.773351e-07 | 0 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 104 | 1.940845e-07 | 0 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 104 | 1.940845e-07 | 0 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 26 | 1.997830e-07 | 0 |
| HPA | HPA:0400652 | Rectum; fibroblasts[≥Medium] | Rectum; fibroblasts[≥Medium] | 12 | 2.122281e-07 | 0 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 18 | 2.396640e-07 | 0 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 102 | 2.542676e-07 | 0 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 102 | 2.542676e-07 | 0 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 101 | 4.314155e-07 | 0 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 97 | 4.341425e-07 | 0 |
| HPA | HPA:0030433 | Appendix; germinal center cells[High] | Appendix; germinal center cells[High] | 11 | 4.477303e-07 | 0 |
| HPA | HPA:0130000 | Colon | Colon | 108 | 4.622503e-07 | 0 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 20 | 5.981745e-07 | 0 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 15 | 6.298346e-07 | 0 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 18 | 6.815327e-07 | 0 |
| HPA | HPA:0050093 | Breast; myoepithelial cells[High] | Breast; myoepithelial cells[High] | 29 | 7.015805e-07 | 0 |
| HPA | HPA:0090161 | Cerebellum; Purkinje cells[≥Low] | Cerebellum; Purkinje cells[≥Low] | 87 | 7.256218e-07 | 0 |
| HPA | HPA:0080123 | Caudate; glial cells[High] | Caudate; glial cells[High] | 26 | 8.480261e-07 | 0 |
| HPA | HPA:0400651 | Rectum; fibroblasts[≥Low] | Rectum; fibroblasts[≥Low] | 12 | 8.774402e-07 | 0 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 44 | 9.196948e-07 | 0 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 97 | 9.548442e-07 | 0 |
| HPA | HPA:0500653 | Soft tissue 1; fibroblasts[High] | Soft tissue 1; fibroblasts[High] | 23 | 9.571249e-07 | 0 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 16 | 9.612212e-07 | 0 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 47 | 9.983877e-07 | 0 |
| HPA | HPA:0050000 | Breast | Breast | 100 | 1.041224e-06 | 0 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 24 | 1.095496e-06 | 0 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 27 | 1.110748e-06 | 0 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 91 | 1.117289e-06 | 0 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 100 | 1.188053e-06 | 0 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 35 | 1.192416e-06 | 0 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 21 | 1.240498e-06 | 0 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 87 | 1.270012e-06 | 0 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 97 | 1.340839e-06 | 0 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 88 | 1.407029e-06 | 0 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 97 | 1.578641e-06 | 0 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 97 | 1.578641e-06 | 0 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 56 | 1.639242e-06 | 0 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 18 | 1.713224e-06 | 0 |
| HPA | HPA:0060103 | Bronchus; respiratory epithelial cells[High] | Bronchus; respiratory epithelial cells[High] | 44 | 1.983818e-06 | 0 |
| HPA | HPA:0131302 | Colon; enterocytes[≥Medium] | Colon; enterocytes[≥Medium] | 19 | 2.025448e-06 | 0 |
| HPA | HPA:0400242 | Rectum; peripheral nerve/ganglion[≥Medium] | Rectum; peripheral nerve/ganglion[≥Medium] | 14 | 2.059797e-06 | 0 |
| HPA | HPA:0471492 | Skin 2; vascular mural cells[≥Medium] | Skin 2; vascular mural cells[≥Medium] | 14 | 2.059797e-06 | 0 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 16 | 2.114610e-06 | 0 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 91 | 2.174817e-06 | 0 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 16 | 2.624715e-06 | 0 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 87 | 2.709395e-06 | 0 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 19 | 2.726778e-06 | 0 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 101 | 2.777882e-06 | 0 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 101 | 2.995735e-06 | 0 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 72 | 4.347445e-06 | 0 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 24 | 4.435735e-06 | 0 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 15 | 4.721671e-06 | 0 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 17 | 5.567684e-06 | 0 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 70 | 5.636605e-06 | 0 |
| HPA | HPA:0031302 | Appendix; enterocytes[≥Medium] | Appendix; enterocytes[≥Medium] | 18 | 5.723027e-06 | 0 |
| HPA | HPA:0340000 | Ovary | Ovary | 84 | 5.728762e-06 | 0 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 25 | 5.960537e-06 | 0 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 13 | 6.695986e-06 | 0 |
| HPA | HPA:0380521 | Placenta; trophoblastic cells[≥Low] | Placenta; trophoblastic cells[≥Low] | 92 | 7.460455e-06 | 0 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 80 | 8.016859e-06 | 0 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 94 | 8.623395e-06 | 0 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 102 | 8.989865e-06 | 0 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 102 | 8.989865e-06 | 0 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 98 | 9.446790e-06 | 0 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 98 | 9.446790e-06 | 0 |
| HPA | HPA:0380523 | Placenta; trophoblastic cells[High] | Placenta; trophoblastic cells[High] | 44 | 1.097166e-05 | 0 |
| HPA | HPA:0600443 | Tonsil; non-germinal center cells[High] | Tonsil; non-germinal center cells[High] | 35 | 1.303469e-05 | 0 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 30 | 1.568281e-05 | 0 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 77 | 1.600170e-05 | 0 |
| HPA | HPA:0461393 | Skin 1; cells in basal layer[High] | Skin 1; cells in basal layer[High] | 13 | 1.655238e-05 | 0 |
| HPA | HPA:0160253 | Endometrium 1; cells in endometrial stroma[High] | Endometrium 1; cells in endometrial stroma[High] | 19 | 1.776533e-05 | 0 |
| HPA | HPA:0471493 | Skin 2; vascular mural cells[High] | Skin 2; vascular mural cells[High] | 11 | 1.823376e-05 | 0 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 71 | 1.839128e-05 | 0 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 70 | 1.925333e-05 | 0 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 45 | 2.634993e-05 | 0 |
| HPA | HPA:0030892 | Appendix; goblet cells[≥Medium] | Appendix; goblet cells[≥Medium] | 16 | 2.679979e-05 | 0 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 33 | 2.708471e-05 | 0 |
| HPA | HPA:0170253 | Endometrium 2; cells in endometrial stroma[High] | Endometrium 2; cells in endometrial stroma[High] | 17 | 2.860611e-05 | 0 |
| HPA | HPA:0300000 | Lung | Lung | 99 | 3.107580e-05 | 0 |
| HPA | HPA:0270000 | Kidney | Kidney | 105 | 3.426556e-05 | 0 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 21 | 3.627479e-05 | 0 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 101 | 3.649426e-05 | 0 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 101 | 3.649426e-05 | 0 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 20 | 3.950205e-05 | 0 |
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 23 | 4.198767e-05 | 0 |
| HPA | HPA:0031292 | Appendix; endocrine cells[≥Medium] | Appendix; endocrine cells[≥Medium] | 17 | 4.247581e-05 | 0 |
| HPA | HPA:0570731 | Testis; Leydig cells[≥Low] | Testis; Leydig cells[≥Low] | 97 | 4.402853e-05 | 0 |
| HPA | HPA:0030431 | Appendix; germinal center cells[≥Low] | Appendix; germinal center cells[≥Low] | 15 | 4.786396e-05 | 0 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 14 | 5.166453e-05 | 0 |
| HPA | HPA:0400243 | Rectum; peripheral nerve/ganglion[High] | Rectum; peripheral nerve/ganglion[High] | 10 | 5.201354e-05 | 0 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 84 | 5.764843e-05 | 0 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 75 | 6.739820e-05 | 0 |
| HPA | HPA:0530723 | Spleen; cells in white pulp[High] | Spleen; cells in white pulp[High] | 26 | 6.838145e-05 | 0 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 52 | 6.864590e-05 | 0 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 67 | 7.371584e-05 | 0 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 87 | 7.462825e-05 | 0 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 81 | 7.664859e-05 | 0 |
| HPA | HPA:0031301 | Appendix; enterocytes[≥Low] | Appendix; enterocytes[≥Low] | 19 | 7.728129e-05 | 0 |
| HPA | HPA:0400892 | Rectum; goblet cells[≥Medium] | Rectum; goblet cells[≥Medium] | 16 | 8.926054e-05 | 0 |
| HPA | HPA:0400241 | Rectum; peripheral nerve/ganglion[≥Low] | Rectum; peripheral nerve/ganglion[≥Low] | 14 | 9.206306e-05 | 0 |
| HPA | HPA:0470683 | Skin 2; epidermal cells[High] | Skin 2; epidermal cells[High] | 29 | 1.041215e-04 | 0 |
| HPA | HPA:0290402 | Liver; hepatocytes[≥Medium] | Liver; hepatocytes[≥Medium] | 64 | 1.049146e-04 | 0 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 47 | 1.049584e-04 | 0 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 18 | 1.118636e-04 | 0 |
| HPA | HPA:0461492 | Skin 1; vascular mural cells[≥Medium] | Skin 1; vascular mural cells[≥Medium] | 12 | 1.163300e-04 | 0 |
| HPA | HPA:0030432 | Appendix; germinal center cells[≥Medium] | Appendix; germinal center cells[≥Medium] | 13 | 1.171598e-04 | 0 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 76 | 1.303683e-04 | 0 |
| HPA | HPA:0030053 | Appendix; glandular cells[High] | Appendix; glandular cells[High] | 41 | 1.337905e-04 | 0 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 41 | 1.337905e-04 | 0 |
| HPA | HPA:0570000 | Testis | Testis | 109 | 1.338459e-04 | 0 |
| HPA | HPA:0131292 | Colon; endocrine cells[≥Medium] | Colon; endocrine cells[≥Medium] | 17 | 1.431271e-04 | 0 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 16 | 1.470282e-04 | 0 |
| HPA | HPA:0401292 | Rectum; endocrine cells[≥Medium] | Rectum; endocrine cells[≥Medium] | 17 | 1.588367e-04 | 0 |
| HPA | HPA:0131301 | Colon; enterocytes[≥Low] | Colon; enterocytes[≥Low] | 19 | 1.788160e-04 | 0 |
| HPA | HPA:0400891 | Rectum; goblet cells[≥Low] | Rectum; goblet cells[≥Low] | 17 | 1.950468e-04 | 0 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 31 | 1.973567e-04 | 0 |
| HPA | HPA:0131331 | Colon; mucosal lymphoid cells[≥Low] | Colon; mucosal lymphoid cells[≥Low] | 19 | 2.075352e-04 | 0 |
| HPA | HPA:0131332 | Colon; mucosal lymphoid cells[≥Medium] | Colon; mucosal lymphoid cells[≥Medium] | 16 | 2.125596e-04 | 0 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 40 | 2.230767e-04 | 0 |
| HPA | HPA:0401301 | Rectum; enterocytes[≥Low] | Rectum; enterocytes[≥Low] | 19 | 2.267279e-04 | 0 |
| HPA | HPA:0030443 | Appendix; non-germinal center cells[High] | Appendix; non-germinal center cells[High] | 9 | 2.629814e-04 | 0 |
| HPA | HPA:0031291 | Appendix; endocrine cells[≥Low] | Appendix; endocrine cells[≥Low] | 17 | 2.635349e-04 | 0 |
| HPA | HPA:0461493 | Skin 1; vascular mural cells[High] | Skin 1; vascular mural cells[High] | 10 | 2.737429e-04 | 0 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 65 | 3.065022e-04 | 0 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 65 | 3.065022e-04 | 0 |
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 16 | 3.254156e-04 | 0 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 13 | 3.357933e-04 | 0 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 17 | 3.419987e-04 | 0 |
| HPA | HPA:0150892 | Duodenum; goblet cells[≥Medium] | Duodenum; goblet cells[≥Medium] | 15 | 3.587537e-04 | 0 |
| HPA | HPA:0630053 | Cervix; glandular cells[High] | Cervix; glandular cells[High] | 30 | 3.707927e-04 | 0 |
| HPA | HPA:0130892 | Colon; goblet cells[≥Medium] | Colon; goblet cells[≥Medium] | 15 | 3.723610e-04 | 0 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 14 | 3.864630e-04 | 0 |
| HPA | HPA:0030891 | Appendix; goblet cells[≥Low] | Appendix; goblet cells[≥Low] | 16 | 4.139235e-04 | 0 |
| HPA | HPA:0400201 | Rectum; endothelial cells[≥Low] | Rectum; endothelial cells[≥Low] | 13 | 4.388233e-04 | 0 |
| HPA | HPA:0480892 | Small intestine; goblet cells[≥Medium] | Small intestine; goblet cells[≥Medium] | 15 | 4.476158e-04 | 0 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 62 | 4.508653e-04 | 0 |
| HPA | HPA:0151301 | Duodenum; enterocytes[≥Low] | Duodenum; enterocytes[≥Low] | 19 | 4.747343e-04 | 0 |
| HPA | HPA:0131303 | Colon; enterocytes[High] | Colon; enterocytes[High] | 12 | 5.044757e-04 | 0 |
| HPA | HPA:0030893 | Appendix; goblet cells[High] | Appendix; goblet cells[High] | 11 | 5.241492e-04 | 0 |
| HPA | HPA:0131291 | Colon; endocrine cells[≥Low] | Colon; endocrine cells[≥Low] | 17 | 6.011157e-04 | 0 |
| HPA | HPA:0060101 | Bronchus; respiratory epithelial cells[≥Low] | Bronchus; respiratory epithelial cells[≥Low] | 84 | 6.142597e-04 | 0 |
| HPA | HPA:0220053 | Gallbladder; glandular cells[High] | Gallbladder; glandular cells[High] | 52 | 6.408233e-04 | 0 |
| HPA | HPA:0151292 | Duodenum; endocrine cells[≥Medium] | Duodenum; endocrine cells[≥Medium] | 17 | 6.584576e-04 | 0 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 16 | 6.588307e-04 | 0 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 81 | 6.643739e-04 | 0 |
| HPA | HPA:0401291 | Rectum; endocrine cells[≥Low] | Rectum; endocrine cells[≥Low] | 17 | 6.993840e-04 | 0 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 102 | 7.323040e-04 | 0 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 74 | 7.448331e-04 | 0 |
| HPA | HPA:0150891 | Duodenum; goblet cells[≥Low] | Duodenum; goblet cells[≥Low] | 16 | 7.738709e-04 | 0 |
| HPA | HPA:0031303 | Appendix; enterocytes[High] | Appendix; enterocytes[High] | 11 | 8.431882e-04 | 0 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 16 | 8.512772e-04 | 0 |
| HPA | HPA:0481292 | Small intestine; endocrine cells[≥Medium] | Small intestine; endocrine cells[≥Medium] | 17 | 9.134837e-04 | 0 |
| HPA | HPA:0010013 | Adipose tissue; adipocytes[High] | Adipose tissue; adipocytes[High] | 17 | 9.134837e-04 | 0 |
| HPA | HPA:0480891 | Small intestine; goblet cells[≥Low] | Small intestine; goblet cells[≥Low] | 16 | 9.355781e-04 | 0 |
| HPA | HPA:0490693 | Smooth muscle; smooth muscle cells[High] | Smooth muscle; smooth muscle cells[High] | 20 | 9.574971e-04 | 0 |
| HPA | HPA:0130891 | Colon; goblet cells[≥Low] | Colon; goblet cells[≥Low] | 16 | 9.958726e-04 | 0 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 78 | 1.075637e-03 | 0 |
| HPA | HPA:0151303 | Duodenum; enterocytes[High] | Duodenum; enterocytes[High] | 12 | 1.104545e-03 | 0 |
| HPA | HPA:0481301 | Small intestine; enterocytes[≥Low] | Small intestine; enterocytes[≥Low] | 19 | 1.107061e-03 | 0 |
| HPA | HPA:0241101 | Heart muscle; cardiomyocytes[≥Low] | Heart muscle; cardiomyocytes[≥Low] | 87 | 1.329201e-03 | 0 |
| HPA | HPA:0240000 | Heart muscle | Heart muscle | 87 | 1.329201e-03 | 0 |
| HPA | HPA:0270361 | Kidney; cells in tubules[≥Low] | Kidney; cells in tubules[≥Low] | 93 | 1.332888e-03 | 0 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 34 | 1.339118e-03 | 0 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 83 | 1.373819e-03 | 0 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 83 | 1.373819e-03 | 0 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 50 | 1.473914e-03 | 0 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 33 | 1.544641e-03 | 0 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 12 | 1.559789e-03 | 0 |
| HPA | HPA:0390053 | Prostate; glandular cells[High] | Prostate; glandular cells[High] | 31 | 1.596398e-03 | 0 |
| HPA | HPA:0481303 | Small intestine; enterocytes[High] | Small intestine; enterocytes[High] | 12 | 1.768928e-03 | 0 |
| HPA | HPA:0130893 | Colon; goblet cells[High] | Colon; goblet cells[High] | 11 | 1.842342e-03 | 0 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 96 | 2.070345e-03 | 0 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 23 | 2.159589e-03 | 0 |
| HPA | HPA:0401331 | Rectum; mucosal lymphoid cells[≥Low] | Rectum; mucosal lymphoid cells[≥Low] | 18 | 2.208884e-03 | 0 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 94 | 2.254504e-03 | 0 |
| HPA | HPA:0151291 | Duodenum; endocrine cells[≥Low] | Duodenum; endocrine cells[≥Low] | 17 | 2.299008e-03 | 0 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 52 | 2.329342e-03 | 0 |
| HPA | HPA:0151352 | Duodenum; paneth cells[≥Medium] | Duodenum; paneth cells[≥Medium] | 12 | 2.355394e-03 | 0 |
| HPA | HPA:0481291 | Small intestine; endocrine cells[≥Low] | Small intestine; endocrine cells[≥Low] | 17 | 2.361149e-03 | 0 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 70 | 2.440452e-03 | 0 |
| HPA | HPA:0400893 | Rectum; goblet cells[High] | Rectum; goblet cells[High] | 11 | 2.534785e-03 | 0 |
| HPA | HPA:0320101 | Nasopharynx; respiratory epithelial cells[≥Low] | Nasopharynx; respiratory epithelial cells[≥Low] | 81 | 2.870052e-03 | 0 |
| HPA | HPA:0130651 | Colon; fibroblasts[≥Low] | Colon; fibroblasts[≥Low] | 8 | 2.982862e-03 | 0 |
| HPA | HPA:0570773 | Testis; peritubular cells[High] | Testis; peritubular cells[High] | 11 | 3.158999e-03 | 0 |
| HPA | HPA:0481351 | Small intestine; paneth cells[≥Low] | Small intestine; paneth cells[≥Low] | 12 | 3.228798e-03 | 0 |
| HPA | HPA:0270353 | Kidney; cells in glomeruli[High] | Kidney; cells in glomeruli[High] | 23 | 3.245565e-03 | 0 |
| HPA | HPA:0130201 | Colon; endothelial cells[≥Low] | Colon; endothelial cells[≥Low] | 80 | 3.259857e-03 | 0 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 77 | 3.266556e-03 | 0 |
| HPA | HPA:0351183 | Pancreas; pancreatic endocrine cells[High] | Pancreas; pancreatic endocrine cells[High] | 22 | 3.974085e-03 | 0 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 64 | 4.347527e-03 | 0 |
| HPA | HPA:0401293 | Rectum; endocrine cells[High] | Rectum; endocrine cells[High] | 12 | 4.373809e-03 | 0 |
| HPA | HPA:0400202 | Rectum; endothelial cells[≥Medium] | Rectum; endothelial cells[≥Medium] | 10 | 4.595423e-03 | 0 |
| HPA | HPA:0481352 | Small intestine; paneth cells[≥Medium] | Small intestine; paneth cells[≥Medium] | 11 | 4.624049e-03 | 0 |
| HPA | HPA:0010012 | Adipose tissue; adipocytes[≥Medium] | Adipose tissue; adipocytes[≥Medium] | 42 | 4.745671e-03 | 0 |
| HPA | HPA:0401303 | Rectum; enterocytes[High] | Rectum; enterocytes[High] | 11 | 4.818442e-03 | 0 |
| HPA | HPA:0510653 | Soft tissue 2; fibroblasts[High] | Soft tissue 2; fibroblasts[High] | 17 | 4.842683e-03 | 0 |
| HPA | HPA:0031293 | Appendix; endocrine cells[High] | Appendix; endocrine cells[High] | 11 | 5.019887e-03 | 0 |
| HPA | HPA:0570772 | Testis; peritubular cells[≥Medium] | Testis; peritubular cells[≥Medium] | 17 | 5.475110e-03 | 0 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 72 | 5.613584e-03 | 0 |
| HPA | HPA:0291163 | Liver; cholangiocytes[High] | Liver; cholangiocytes[High] | 13 | 5.755045e-03 | 0 |
| HPA | HPA:0130653 | Colon; fibroblasts[High] | Colon; fibroblasts[High] | 6 | 5.835021e-03 | 0 |
| HPA | HPA:0151351 | Duodenum; paneth cells[≥Low] | Duodenum; paneth cells[≥Low] | 12 | 6.292875e-03 | 0 |
| HPA | HPA:0460663 | Skin 1; keratinocytes[High] | Skin 1; keratinocytes[High] | 19 | 6.662961e-03 | 0 |
| HPA | HPA:0500111 | Soft tissue 1; chondrocytes[≥Low] | Soft tissue 1; chondrocytes[≥Low] | 41 | 6.731737e-03 | 0 |
| HPA | HPA:0131333 | Colon; mucosal lymphoid cells[High] | Colon; mucosal lymphoid cells[High] | 9 | 7.348016e-03 | 0 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 42 | 8.263742e-03 | 0 |
| HPA | HPA:0500703 | Soft tissue 1; peripheral nerve[High] | Soft tissue 1; peripheral nerve[High] | 11 | 8.384571e-03 | 0 |
| HPA | HPA:0030052 | Appendix; glandular cells[≥Medium] | Appendix; glandular cells[≥Medium] | 77 | 1.002773e-02 | 0 |
| HPA | HPA:0400653 | Rectum; fibroblasts[High] | Rectum; fibroblasts[High] | 6 | 1.039736e-02 | 0 |
| HPA | HPA:0130243 | Colon; peripheral nerve/ganglion[High] | Colon; peripheral nerve/ganglion[High] | 22 | 1.064358e-02 | 0 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 21 | 1.183317e-02 | 0 |
| HPA | HPA:0480893 | Small intestine; goblet cells[High] | Small intestine; goblet cells[High] | 10 | 1.204749e-02 | 0 |
| HPA | HPA:0150893 | Duodenum; goblet cells[High] | Duodenum; goblet cells[High] | 10 | 1.204749e-02 | 0 |
| HPA | HPA:0130652 | Colon; fibroblasts[≥Medium] | Colon; fibroblasts[≥Medium] | 7 | 1.338503e-02 | 0 |
| HPA | HPA:0500702 | Soft tissue 1; peripheral nerve[≥Medium] | Soft tissue 1; peripheral nerve[≥Medium] | 29 | 1.532462e-02 | 0 |
| HPA | HPA:0440343 | Skeletal muscle; myocytes[High] | Skeletal muscle; myocytes[High] | 22 | 1.533758e-02 | 0 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 23 | 1.753764e-02 | 0 |
| HPA | HPA:0050013 | Breast; adipocytes[High] | Breast; adipocytes[High] | 12 | 1.817632e-02 | 0 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 15 | 1.831115e-02 | 0 |
| HPA | HPA:0400203 | Rectum; endothelial cells[High] | Rectum; endothelial cells[High] | 7 | 1.972504e-02 | 0 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 73 | 2.360506e-02 | 0 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 18 | 2.383078e-02 | 0 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 50 | 2.464249e-02 | 0 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 44 | 2.838903e-02 | 0 |
| HPA | HPA:0461422 | Skin 1; eccrine glands[≥Medium] | Skin 1; eccrine glands[≥Medium] | 9 | 3.006165e-02 | 0 |
| HPA | HPA:0480052 | Small intestine; glandular cells[≥Medium] | Small intestine; glandular cells[≥Medium] | 81 | 3.143880e-02 | 0 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 56 | 3.226543e-02 | 0 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 75 | 3.256439e-02 | 0 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 75 | 3.256439e-02 | 0 |
| HPA | HPA:0481353 | Small intestine; paneth cells[High] | Small intestine; paneth cells[High] | 8 | 3.591008e-02 | 0 |
| HPA | HPA:0470682 | Skin 2; epidermal cells[≥Medium] | Skin 2; epidermal cells[≥Medium] | 60 | 3.782372e-02 | 0 |
| HPA | HPA:0150053 | Duodenum; glandular cells[High] | Duodenum; glandular cells[High] | 44 | 3.950456e-02 | 0 |
| HPA | HPA:0400052 | Rectum; glandular cells[≥Medium] | Rectum; glandular cells[≥Medium] | 81 | 4.131258e-02 | 0 |
| HPA | HPA:0510703 | Soft tissue 2; peripheral nerve[High] | Soft tissue 2; peripheral nerve[High] | 11 | 4.820971e-02 | 0 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 41 | 9.327769e-11 | 0 |
| MIRNA | MIRNA:hsa-mir-100-5p | hsa-mir-100-5p | hsa-mir-100-5p | 18 | 3.241509e-10 | 0 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 37 | 1.008558e-09 | 0 |
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 31 | 2.086431e-09 | 0 |
| MIRNA | MIRNA:hsa-mir-1296-5p | hsa-mir-1296-5p | hsa-mir-1296-5p | 13 | 2.974366e-09 | 0 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 23 | 3.717773e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-652-3p | hsa-mir-652-3p | hsa-mir-652-3p | 10 | 4.215104e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-149-5p | hsa-mir-149-5p | hsa-mir-149-5p | 15 | 1.595414e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 32 | 1.019044e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-186-5p | hsa-mir-186-5p | hsa-mir-186-5p | 19 | 1.659305e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-331-3p | hsa-mir-331-3p | hsa-mir-331-3p | 25 | 5.676226e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-222-3p | hsa-mir-222-3p | hsa-mir-222-3p | 13 | 5.766519e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-25-3p | hsa-mir-25-3p | hsa-mir-25-3p | 14 | 5.898672e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 13 | 8.317987e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-15b-5p | hsa-mir-15b-5p | hsa-mir-15b-5p | 18 | 8.929933e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-92b-3p | hsa-mir-92b-3p | hsa-mir-92b-3p | 16 | 1.910564e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-30a-5p | hsa-mir-30a-5p | hsa-mir-30a-5p | 17 | 1.968168e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-493-3p | hsa-mir-493-3p | hsa-mir-493-3p | 6 | 2.128986e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-484 | hsa-mir-484 | hsa-mir-484 | 32 | 2.602259e-02 | 0 |
| MIRNA | MIRNA:hsa-let-7a-5p | hsa-let-7a-5p | hsa-let-7a-5p | 15 | 3.985743e-02 | 0 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M08205 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | 122 | 0.000011 | 0 |
| TF | TF:M11392_1 | Factor: Erg; motif: NACCGGAARYN; match class: 1 | Factor: Erg; motif: NACCGGAARYN; match class: 1 | 49 | 0.000012 | 0 |
| TF | TF:M02065_1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | 79 | 0.000015 | 0 |
| TF | TF:M00025_1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | 59 | 0.000019 | 0 |
| TF | TF:M11530 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | 122 | 0.000028 | 0 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 126 | 0.000041 | 0 |
| TF | TF:M02052 | Factor: EHF; motif: CSCGGAARTN | Factor: EHF; motif: CSCGGAARTN | 98 | 0.000042 | 0 |
| TF | TF:M12600 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | 89 | 0.000052 | 0 |
| TF | TF:M11396_1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | 62 | 0.000070 | 0 |
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 124 | 0.000072 | 0 |
| TF | TF:M02070 | Factor: TEL1; motif: CNCGGAANNN | Factor: TEL1; motif: CNCGGAANNN | 102 | 0.000080 | 0 |
| TF | TF:M04691_1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | 100 | 0.000082 | 0 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 123 | 0.000090 | 0 |
| TF | TF:M03975_1 | Factor: ERG; motif: ACCGGAARTN; match class: 1 | Factor: ERG; motif: ACCGGAARTN; match class: 1 | 54 | 0.000091 | 0 |
| TF | TF:M11530_1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | 116 | 0.000092 | 0 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 127 | 0.000095 | 0 |
| TF | TF:M11400 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 96 | 0.000161 | 0 |
| TF | TF:M11400_1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | 55 | 0.000172 | 0 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 122 | 0.000202 | 0 |
| TF | TF:M12238_1 | Factor: DREF; motif: MTRTCGCGAYAK; match class: 1 | Factor: DREF; motif: MTRTCGCGAYAK; match class: 1 | 13 | 0.000208 | 0 |
| TF | TF:M10438 | Factor: ZF5; motif: GGSGCGCGS | Factor: ZF5; motif: GGSGCGCGS | 127 | 0.000229 | 0 |
| TF | TF:M07380 | Factor: E2F-4; motif: NTTTCSCGCC | Factor: E2F-4; motif: NTTTCSCGCC | 113 | 0.000272 | 0 |
| TF | TF:M08913 | Factor: FLI-1; motif: NAYTTCCGGT | Factor: FLI-1; motif: NAYTTCCGGT | 85 | 0.000296 | 0 |
| TF | TF:M13031_1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | 60 | 0.000325 | 0 |
| TF | TF:M11392 | Factor: Erg; motif: NACCGGAARYN | Factor: Erg; motif: NACCGGAARYN | 87 | 0.000428 | 0 |
| TF | TF:M04710_1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | 104 | 0.000489 | 0 |
| TF | TF:M00426_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 67 | 0.000499 | 0 |
| TF | TF:M01078 | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN | 79 | 0.000610 | 0 |
| TF | TF:M09606 | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | 70 | 0.000637 | 0 |
| TF | TF:M11435 | Factor: Elk-1; motif: NNCCGGAAGTN | Factor: Elk-1; motif: NNCCGGAAGTN | 105 | 0.000653 | 0 |
| TF | TF:M00025 | Factor: Elk-1; motif: NNNNCCGGAARTNN | Factor: Elk-1; motif: NNNNCCGGAARTNN | 95 | 0.000698 | 0 |
| TF | TF:M04517 | Factor: E2F2; motif: AAAATGGCGCCATTTT | Factor: E2F2; motif: AAAATGGCGCCATTTT | 89 | 0.000817 | 0 |
| TF | TF:M02062 | Factor: Erg; motif: ACCGGAAGTN | Factor: Erg; motif: ACCGGAAGTN | 82 | 0.000876 | 0 |
| TF | TF:M01660 | Factor: GABP-alpha; motif: CTTCCK | Factor: GABP-alpha; motif: CTTCCK | 101 | 0.001028 | 0 |
| TF | TF:M11396 | Factor: Erg; motif: NACCGGAARTN | Factor: Erg; motif: NACCGGAARTN | 99 | 0.001118 | 0 |
| TF | TF:M03977_1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | 57 | 0.001149 | 0 |
| TF | TF:M11018_1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | 125 | 0.001288 | 0 |
| TF | TF:M03988_1 | Factor: FLI1; motif: ACCGGAARTN; match class: 1 | Factor: FLI1; motif: ACCGGAARTN; match class: 1 | 42 | 0.001343 | 0 |
| TF | TF:M08913_1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | 43 | 0.001384 | 0 |
| TF | TF:M09894 | Factor: E2F-4; motif: SNGGGCGGGAANN | Factor: E2F-4; motif: SNGGGCGGGAANN | 126 | 0.001515 | 0 |
| TF | TF:M12238 | Factor: DREF; motif: MTRTCGCGAYAK | Factor: DREF; motif: MTRTCGCGAYAK | 13 | 0.001534 | 0 |
| TF | TF:M07140_1 | Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 | Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 | 10 | 0.001588 | 0 |
| TF | TF:M08205_1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | 97 | 0.001590 | 0 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 128 | 0.001760 | 0 |
| TF | TF:M02070_1 | Factor: TEL1; motif: CNCGGAANNN; match class: 1 | Factor: TEL1; motif: CNCGGAANNN; match class: 1 | 58 | 0.001862 | 0 |
| TF | TF:M08286 | Factor: Fli-1:FOXI1; motif: NCCGGATGTTKAY | Factor: Fli-1:FOXI1; motif: NCCGGATGTTKAY | 54 | 0.002094 | 0 |
| TF | TF:M11448 | Factor: Elf-1; motif: NANGCGGAAGTN | Factor: Elf-1; motif: NANGCGGAAGTN | 78 | 0.002178 | 0 |
| TF | TF:M00430 | Factor: E2F-1; motif: NTTSGCGG | Factor: E2F-1; motif: NTTSGCGG | 81 | 0.002267 | 0 |
| TF | TF:M08982_1 | Factor: YY1; motif: NAANATGGCGNNN; match class: 1 | Factor: YY1; motif: NAANATGGCGNNN; match class: 1 | 29 | 0.002436 | 0 |
| TF | TF:M00426 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 105 | 0.002582 | 0 |
| TF | TF:M01752_1 | Factor: ERG; motif: ACCGGAART; match class: 1 | Factor: ERG; motif: ACCGGAART; match class: 1 | 48 | 0.002683 | 0 |
| TF | TF:M03924_1 | Factor: YY1; motif: NNCGCCATTNN; match class: 1 | Factor: YY1; motif: NNCGCCATTNN; match class: 1 | 48 | 0.002704 | 0 |
| TF | TF:M08229 | Factor: Elk-1:SREBP-2; motif: RTCACGTGACCGGAAGN | Factor: Elk-1:SREBP-2; motif: RTCACGTGACCGGAAGN | 90 | 0.003100 | 0 |
| TF | TF:M04714 | Factor: Elf-1; motif: ACTTCCGGG | Factor: Elf-1; motif: ACTTCCGGG | 79 | 0.003115 | 0 |
| TF | TF:M03975 | Factor: ERG; motif: ACCGGAARTN | Factor: ERG; motif: ACCGGAARTN | 93 | 0.003258 | 0 |
| TF | TF:M09608_1 | Factor: Erg; motif: NNACCGGAARTSN; match class: 1 | Factor: Erg; motif: NNACCGGAARTSN; match class: 1 | 36 | 0.003315 | 0 |
| TF | TF:M02071 | Factor: ETV7; motif: NCCGGAANNN | Factor: ETV7; motif: NCCGGAANNN | 94 | 0.003360 | 0 |
| TF | TF:M11404_1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | 43 | 0.003881 | 0 |
| TF | TF:M09905 | Factor: SAP-1; motif: NNCCGGAAGTGN | Factor: SAP-1; motif: NNCCGGAAGTGN | 82 | 0.003911 | 0 |
| TF | TF:M11424 | Factor: Erm; motif: NNSCGGAWGYN | Factor: Erm; motif: NNSCGGAWGYN | 81 | 0.004322 | 0 |
| TF | TF:M00425_1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | 61 | 0.004340 | 0 |
| TF | TF:M11447 | Factor: Elf-1; motif: NAMCCGGAAGTN | Factor: Elf-1; motif: NAMCCGGAAGTN | 78 | 0.004373 | 0 |
| TF | TF:M00740_1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | 55 | 0.004531 | 0 |
| TF | TF:M00430_1 | Factor: E2F-1; motif: NTTSGCGG; match class: 1 | Factor: E2F-1; motif: NTTSGCGG; match class: 1 | 37 | 0.004545 | 0 |
| TF | TF:M11428 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 74 | 0.004654 | 0 |
| TF | TF:M03977 | Factor: ETS1; motif: ACCGGAARYN | Factor: ETS1; motif: ACCGGAARYN | 96 | 0.004850 | 0 |
| TF | TF:M02059 | Factor: ELK-1; motif: ACCGGAAGTN | Factor: ELK-1; motif: ACCGGAAGTN | 89 | 0.005375 | 0 |
| TF | TF:M00716_1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | 116 | 0.006043 | 0 |
| TF | TF:M10785 | Factor: hoxa9; motif: RTCGTWANNN | Factor: hoxa9; motif: RTCGTWANNN | 62 | 0.006448 | 0 |
| TF | TF:M02073 | Factor: Fli-1; motif: ACCGGAAGYN | Factor: Fli-1; motif: ACCGGAAGYN | 64 | 0.006714 | 0 |
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 111 | 0.007997 | 0 |
| TF | TF:M11452 | Factor: Elf-1; motif: NANGCGGAAGTR | Factor: Elf-1; motif: NANGCGGAAGTR | 67 | 0.008071 | 0 |
| TF | TF:M11316 | Factor: C/EBPbeta; motif: NRTTGCGYAAYN | Factor: C/EBPbeta; motif: NRTTGCGYAAYN | 59 | 0.008210 | 0 |
| TF | TF:M11533_1 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN; match class: 1 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN; match class: 1 | 84 | 0.009004 | 0 |
| TF | TF:M07140 | Factor: Kaiso; motif: NTCTCGCGAGANYTN | Factor: Kaiso; motif: NTCTCGCGAGANYTN | 15 | 0.009291 | 0 |
| TF | TF:M08759_1 | Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 | Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 | 40 | 0.009480 | 0 |
| TF | TF:M09904 | Factor: Elk-1; motif: RCCGGAAGTGN | Factor: Elk-1; motif: RCCGGAAGTGN | 80 | 0.009818 | 0 |
| TF | TF:M01167 | Factor: SAP-1a; motif: NACCGGAAGTV | Factor: SAP-1a; motif: NACCGGAAGTV | 31 | 0.010025 | 0 |
| TF | TF:M02063 | Factor: c-ets-1; motif: ACCGGAWGTN | Factor: c-ets-1; motif: ACCGGAWGTN | 76 | 0.010741 | 0 |
| TF | TF:M03966 | Factor: ELF1; motif: AACCCGGAAGTR | Factor: ELF1; motif: AACCCGGAAGTR | 69 | 0.011220 | 0 |
| TF | TF:M04710 | Factor: CHD2; motif: TCTCGCGAG | Factor: CHD2; motif: TCTCGCGAG | 115 | 0.011571 | 0 |
| TF | TF:M02065 | Factor: ER81; motif: RCCGGAARYN | Factor: ER81; motif: RCCGGAARYN | 108 | 0.012808 | 0 |
| TF | TF:M04515_1 | Factor: E2F-1; motif: WWTGGCGCCAAA; match class: 1 | Factor: E2F-1; motif: WWTGGCGCCAAA; match class: 1 | 105 | 0.012986 | 0 |
| TF | TF:M11533 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN | 110 | 0.013297 | 0 |
| TF | TF:M08982 | Factor: YY1; motif: NAANATGGCGNNN | Factor: YY1; motif: NAANATGGCGNNN | 72 | 0.013717 | 0 |
| TF | TF:M08298 | Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN | Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN | 94 | 0.014708 | 0 |
| TF | TF:M11528_1 | Factor: E2F-2; motif: NTTTTGGCGCCAWWWN; match class: 1 | Factor: E2F-2; motif: NTTTTGGCGCCAWWWN; match class: 1 | 55 | 0.014844 | 0 |
| TF | TF:M08223_1 | Factor: Elk-1:OC-2; motif: RCCGGAASCGATCGATNN; match class: 1 | Factor: Elk-1:OC-2; motif: RCCGGAASCGATCGATNN; match class: 1 | 63 | 0.014989 | 0 |
| TF | TF:M11535 | Factor: E2F-4; motif: TTTTGGCGCCAWWN | Factor: E2F-4; motif: TTTTGGCGCCAWWN | 97 | 0.016836 | 0 |
| TF | TF:M04515 | Factor: E2F-1; motif: WWTGGCGCCAAA | Factor: E2F-1; motif: WWTGGCGCCAAA | 111 | 0.017485 | 0 |
| TF | TF:M12599 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN | 128 | 0.018445 | 0 |
| TF | TF:M07250 | Factor: E2F-1; motif: NNNSSCGCSAANN | Factor: E2F-1; motif: NNNSSCGCSAANN | 96 | 0.019469 | 0 |
| TF | TF:M08298_1 | Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN; match class: 1 | Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN; match class: 1 | 47 | 0.019609 | 0 |
| TF | TF:M11404 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 83 | 0.019947 | 0 |
| TF | TF:M02044 | Factor: YY1; motif: GCCGCCATTTTG | Factor: YY1; motif: GCCGCCATTTTG | 65 | 0.020717 | 0 |
| TF | TF:M00427_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 47 | 0.021649 | 0 |
| TF | TF:M11428_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 32 | 0.021802 | 0 |
| TF | TF:M03988 | Factor: FLI1; motif: ACCGGAARTN | Factor: FLI1; motif: ACCGGAARTN | 80 | 0.022225 | 0 |
| TF | TF:M11414 | Factor: GABP-alpha; motif: NACCGGAAGTN | Factor: GABP-alpha; motif: NACCGGAAGTN | 39 | 0.022945 | 0 |
| TF | TF:M02071_1 | Factor: ETV7; motif: NCCGGAANNN; match class: 1 | Factor: ETV7; motif: NCCGGAANNN; match class: 1 | 52 | 0.023763 | 0 |
| TF | TF:M03983 | Factor: ETV5; motif: NCCGGAWGYN | Factor: ETV5; motif: NCCGGAWGYN | 41 | 0.023939 | 0 |
| TF | TF:M09966_1 | Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 | Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 | 13 | 0.025025 | 0 |
| TF | TF:M01660_1 | Factor: GABP-alpha; motif: CTTCCK; match class: 1 | Factor: GABP-alpha; motif: CTTCCK; match class: 1 | 57 | 0.025298 | 0 |
| TF | TF:M11451 | Factor: Elf-1; motif: NANCCGGAAGTN | Factor: Elf-1; motif: NANCCGGAAGTN | 70 | 0.027998 | 0 |
| TF | TF:M13032_1 | Factor: ETV5; motif: ACCGGAAGTN; match class: 1 | Factor: ETV5; motif: ACCGGAAGTN; match class: 1 | 44 | 0.031149 | 0 |
| TF | TF:M08910_1 | Factor: C/EBPBETA; motif: KRTTGCGYAAY; match class: 1 | Factor: C/EBPBETA; motif: KRTTGCGYAAY; match class: 1 | 41 | 0.031757 | 0 |
| TF | TF:M08525_1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | 120 | 0.033629 | 0 |
| TF | TF:M09632_1 | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN; match class: 1 | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN; match class: 1 | 16 | 0.034571 | 0 |
| TF | TF:M08266_1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | 84 | 0.034802 | 0 |
| TF | TF:M04691 | Factor: Kaiso; motif: TCTCGCGAG | Factor: Kaiso; motif: TCTCGCGAG | 119 | 0.037548 | 0 |
| TF | TF:M09904_1 | Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 | Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 | 37 | 0.038855 | 0 |
| TF | TF:M09905_1 | Factor: SAP-1; motif: NNCCGGAAGTGN; match class: 1 | Factor: SAP-1; motif: NNCCGGAAGTGN; match class: 1 | 39 | 0.038904 | 0 |
| TF | TF:M11450 | Factor: Elf-1; motif: NANSCGGAAGTR | Factor: Elf-1; motif: NANSCGGAAGTR | 60 | 0.039967 | 0 |
| TF | TF:M10956_1 | Factor: isx; motif: NTCRTTAA; match class: 1 | Factor: isx; motif: NTCRTTAA; match class: 1 | 42 | 0.040327 | 0 |
| TF | TF:M03982 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 69 | 0.040561 | 0 |
| TF | TF:M11425 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 73 | 0.042127 | 0 |
| TF | TF:M11435_1 | Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 | Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 | 61 | 0.043845 | 0 |
| TF | TF:M11425_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 33 | 0.044797 | 0 |
| TF | TF:M09900 | Factor: Elf-1; motif: NNANCCGGAAGTGS | Factor: Elf-1; motif: NNANCCGGAAGTGS | 57 | 0.044962 | 0 |
| TF | TF:M08759 | Factor: c-Ets-2; motif: NCCGGAAGTG | Factor: c-Ets-2; motif: NCCGGAAGTG | 79 | 0.049350 | 0 |
| TF | TF:M00740 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | 93 | 0.049838 | 0 |
Community 1
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 22 | 6.225585e-21 | 1 |
| GO:CC | GO:0005759 | mitochondrial matrix | "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] | 16 | 2.204292e-19 | 1 |
| GO:CC | GO:0031966 | mitochondrial membrane | "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] | 17 | 3.176419e-18 | 1 |
| GO:CC | GO:0005740 | mitochondrial envelope | "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] | 17 | 8.990488e-18 | 1 |
| GO:CC | GO:0042645 | mitochondrial nucleoid | "The region of a mitochondrion to which the DNA is confined." [GOC:jl] | 9 | 5.738598e-17 | 1 |
| GO:CC | GO:0009295 | nucleoid | "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689] | 9 | 5.738598e-17 | 1 |
| GO:CC | GO:0031967 | organelle envelope | "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] | 18 | 4.272306e-16 | 1 |
| GO:CC | GO:0019866 | organelle inner membrane | "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] | 13 | 3.260425e-13 | 1 |
| GO:CC | GO:0005743 | mitochondrial inner membrane | "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] | 12 | 4.281722e-12 | 1 |
| GO:CC | GO:0031968 | organelle outer membrane | "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] | 8 | 2.382848e-08 | 1 |
| GO:CC | GO:0019867 | outer membrane | "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] | 8 | 2.533773e-08 | 1 |
| GO:CC | GO:0031090 | organelle membrane | "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] | 18 | 5.009394e-08 | 1 |
| GO:CC | GO:0045259 | proton-transporting ATP synthase complex | "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [ISBN:0198547684, ISBN:0716743663] | 4 | 3.872745e-07 | 1 |
| GO:CC | GO:0005741 | mitochondrial outer membrane | "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] | 7 | 4.291215e-07 | 1 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 20 | 4.742225e-06 | 1 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 20 | 4.742225e-06 | 1 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 20 | 4.742225e-06 | 1 |
| GO:CC | GO:0098803 | respiratory chain complex | "Any protein complex that is part of a respiratory chain." [GOC:dos] | 5 | 1.098566e-05 | 1 |
| GO:CC | GO:0016469 | proton-transporting two-sector ATPase complex | "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483] | 4 | 3.372710e-05 | 1 |
| GO:CC | GO:0098796 | membrane protein complex | "Any protein complex that is part of a membrane." [GOC:dos] | 10 | 9.361406e-05 | 1 |
| GO:CC | GO:0098798 | mitochondrial protein-containing complex | "A protein complex that is part of a mitochondrion." [GOC:dos] | 5 | 2.020555e-04 | 1 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 23 | 3.738882e-04 | 1 |
| GO:CC | GO:0016507 | mitochondrial fatty acid beta-oxidation multienzyme complex | "A multienzyme complex possessing three activities in two subunits (alpha and beta) that catalyzes three steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. The alpha subunit comprises the enoyl-CoA hydratase (ECH) and 3-hydroxyacyl-CoA dehydrogenase (HACD) activities, and the beta subunit contains the acetyl-CoA C-acyltransferase (KACT)/thiolase activity." [GOC:sjm, PMID:29915090] | 2 | 5.748125e-04 | 1 |
| GO:CC | GO:0036125 | fatty acid beta-oxidation multienzyme complex | "A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT)." [GOC:imk, PMID:12115060, PMID:16472743] | 2 | 5.748125e-04 | 1 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 21 | 7.700137e-04 | 1 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 14 | 1.243113e-03 | 1 |
| GO:CC | GO:1990204 | oxidoreductase complex | "Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432] | 4 | 2.778689e-03 | 1 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 10 | 4.015549e-03 | 1 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 10 | 4.545963e-03 | 1 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 10 | 4.564644e-03 | 1 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 10 | 4.564644e-03 | 1 |
| GO:CC | GO:0034703 | cation channel complex | "An ion channel complex through which cations pass." [GOC:mah] | 4 | 1.466334e-02 | 1 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 23 | 1.549527e-02 | 1 |
| GO:CC | GO:1902495 | transmembrane transporter complex | "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586] | 5 | 2.335233e-02 | 1 |
| GO:CC | GO:1990351 | transporter complex | "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578] | 5 | 3.028063e-02 | 1 |
| GO:CC | GO:0098588 | bounding membrane of organelle | "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] | 9 | 4.587291e-02 | 1 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9837999 | Mitochondrial protein degradation | Mitochondrial protein degradation | 8 | 1.161451e-09 | 1 |
| REAC | REAC:R-HSA-1428517 | Aerobic respiration and respiratory electron transport | Aerobic respiration and respiratory electron transport | 8 | 5.218972e-07 | 1 |
| REAC | REAC:R-HSA-8949613 | Cristae formation | Cristae formation | 5 | 6.475806e-07 | 1 |
| REAC | REAC:R-HSA-1592230 | Mitochondrial biogenesis | Mitochondrial biogenesis | 6 | 3.251644e-06 | 1 |
| REAC | REAC:R-HSA-163210 | Formation of ATP by chemiosmotic coupling | Formation of ATP by chemiosmotic coupling | 4 | 8.125184e-06 | 1 |
| REAC | REAC:R-HSA-1268020 | Mitochondrial protein import | Mitochondrial protein import | 5 | 3.272973e-05 | 1 |
| REAC | REAC:R-HSA-9609507 | Protein localization | Protein localization | 5 | 2.617188e-03 | 1 |
| REAC | REAC:R-HSA-8949215 | Mitochondrial calcium ion transport | Mitochondrial calcium ion transport | 3 | 3.022190e-03 | 1 |
| REAC | REAC:R-HSA-1852241 | Organelle biogenesis and maintenance | Organelle biogenesis and maintenance | 6 | 3.132873e-03 | 1 |
| REAC | REAC:R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 2 | 3.199056e-03 | 1 |
| REAC | REAC:R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 2 | 3.199056e-03 | 1 |
| REAC | REAC:R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 2 | 1.064027e-02 | 1 |
| REAC | REAC:R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 2 | 1.064027e-02 | 1 |
| REAC | REAC:R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 2 | 1.064027e-02 | 1 |
| REAC | REAC:R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 2 | 1.594301e-02 | 1 |
| REAC | REAC:R-HSA-1482798 | Acyl chain remodeling of CL | Acyl chain remodeling of CL | 2 | 1.594301e-02 | 1 |
| REAC | REAC:R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 2 | 1.594301e-02 | 1 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 12 | 1.755933e-02 | 1 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0570733 | Testis; Leydig cells[High] | Testis; Leydig cells[High] | 17 | 1.613383e-08 | 1 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 14 | 4.216261e-07 | 1 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 10 | 5.117416e-06 | 1 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 10 | 6.429708e-06 | 1 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 14 | 7.378308e-06 | 1 |
| HPA | HPA:0271133 | Kidney; distal tubules[High] | Kidney; distal tubules[High] | 8 | 8.798087e-06 | 1 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 10 | 1.309374e-05 | 1 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 10 | 1.348791e-05 | 1 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 10 | 1.857109e-05 | 1 |
| HPA | HPA:0290402 | Liver; hepatocytes[≥Medium] | Liver; hepatocytes[≥Medium] | 19 | 2.019505e-05 | 1 |
| HPA | HPA:0241102 | Heart muscle; cardiomyocytes[≥Medium] | Heart muscle; cardiomyocytes[≥Medium] | 20 | 2.051454e-05 | 1 |
| HPA | HPA:0300413 | Lung; macrophages[High] | Lung; macrophages[High] | 13 | 2.154143e-05 | 1 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 10 | 2.493705e-05 | 1 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 21 | 3.565852e-05 | 1 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 10 | 3.887158e-05 | 1 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 10 | 4.095843e-05 | 1 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 10 | 4.314374e-05 | 1 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 21 | 4.627339e-05 | 1 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 13 | 4.883173e-05 | 1 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 16 | 6.249362e-05 | 1 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 10 | 6.388496e-05 | 1 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 10 | 6.794854e-05 | 1 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 10 | 9.634135e-05 | 1 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 21 | 1.216058e-04 | 1 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 20 | 1.804870e-04 | 1 |
| HPA | HPA:0271122 | Kidney; collecting ducts[≥Medium] | Kidney; collecting ducts[≥Medium] | 8 | 1.920019e-04 | 1 |
| HPA | HPA:0290401 | Liver; hepatocytes[≥Low] | Liver; hepatocytes[≥Low] | 21 | 1.925560e-04 | 1 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 9 | 2.185422e-04 | 1 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 10 | 2.407377e-04 | 1 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 10 | 2.674275e-04 | 1 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 19 | 2.848974e-04 | 1 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 15 | 3.647420e-04 | 1 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 9 | 3.913388e-04 | 1 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 12 | 4.843877e-04 | 1 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 12 | 4.843877e-04 | 1 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 20 | 4.881120e-04 | 1 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 21 | 5.012648e-04 | 1 |
| HPA | HPA:0461451 | Skin 1; hair follicles[≥Low] | Skin 1; hair follicles[≥Low] | 7 | 5.656466e-04 | 1 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 10 | 5.985734e-04 | 1 |
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 18 | 6.494138e-04 | 1 |
| HPA | HPA:0271132 | Kidney; distal tubules[≥Medium] | Kidney; distal tubules[≥Medium] | 8 | 7.401223e-04 | 1 |
| HPA | HPA:0570802 | Testis; sertoli cells[≥Medium] | Testis; sertoli cells[≥Medium] | 13 | 8.134973e-04 | 1 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 8 | 8.345967e-04 | 1 |
| HPA | HPA:0271142 | Kidney; proximal tubules (cell body)[≥Medium] | Kidney; proximal tubules (cell body)[≥Medium] | 8 | 8.913923e-04 | 1 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 7 | 9.050843e-04 | 1 |
| HPA | HPA:0570762 | Testis; pachytene spermatocytes[≥Medium] | Testis; pachytene spermatocytes[≥Medium] | 13 | 1.002113e-03 | 1 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 10 | 1.027749e-03 | 1 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 7 | 1.121163e-03 | 1 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 18 | 1.140887e-03 | 1 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 14 | 1.176698e-03 | 1 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 9 | 1.184691e-03 | 1 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 18 | 1.206529e-03 | 1 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 9 | 1.221764e-03 | 1 |
| HPA | HPA:0290000 | Liver | Liver | 21 | 1.302955e-03 | 1 |
| HPA | HPA:0271121 | Kidney; collecting ducts[≥Low] | Kidney; collecting ducts[≥Low] | 8 | 1.306241e-03 | 1 |
| HPA | HPA:0271111 | Kidney; bowman's capsule[≥Low] | Kidney; bowman's capsule[≥Low] | 6 | 1.351088e-03 | 1 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 17 | 1.405497e-03 | 1 |
| HPA | HPA:0291162 | Liver; cholangiocytes[≥Medium] | Liver; cholangiocytes[≥Medium] | 13 | 1.449824e-03 | 1 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 15 | 1.450729e-03 | 1 |
| HPA | HPA:0240000 | Heart muscle | Heart muscle | 21 | 1.454702e-03 | 1 |
| HPA | HPA:0241101 | Heart muscle; cardiomyocytes[≥Low] | Heart muscle; cardiomyocytes[≥Low] | 21 | 1.454702e-03 | 1 |
| HPA | HPA:0271123 | Kidney; collecting ducts[High] | Kidney; collecting ducts[High] | 6 | 1.470423e-03 | 1 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 21 | 1.565063e-03 | 1 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 9 | 1.667567e-03 | 1 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 17 | 1.959610e-03 | 1 |
| HPA | HPA:0530723 | Spleen; cells in white pulp[High] | Spleen; cells in white pulp[High] | 9 | 1.966984e-03 | 1 |
| HPA | HPA:0271143 | Kidney; proximal tubules (cell body)[High] | Kidney; proximal tubules (cell body)[High] | 6 | 1.996825e-03 | 1 |
| HPA | HPA:0461482 | Skin 1; sebaceous glands[≥Medium] | Skin 1; sebaceous glands[≥Medium] | 5 | 2.006669e-03 | 1 |
| HPA | HPA:0151353 | Duodenum; paneth cells[High] | Duodenum; paneth cells[High] | 5 | 2.127639e-03 | 1 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 19 | 2.181083e-03 | 1 |
| HPA | HPA:0461452 | Skin 1; hair follicles[≥Medium] | Skin 1; hair follicles[≥Medium] | 6 | 2.202927e-03 | 1 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 19 | 2.310691e-03 | 1 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 8 | 2.335003e-03 | 1 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 13 | 2.615195e-03 | 1 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 19 | 2.638498e-03 | 1 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 9 | 2.732184e-03 | 1 |
| HPA | HPA:0030893 | Appendix; goblet cells[High] | Appendix; goblet cells[High] | 5 | 3.059756e-03 | 1 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 12 | 3.784398e-03 | 1 |
| HPA | HPA:0031303 | Appendix; enterocytes[High] | Appendix; enterocytes[High] | 5 | 3.872757e-03 | 1 |
| HPA | HPA:0030433 | Appendix; germinal center cells[High] | Appendix; germinal center cells[High] | 4 | 3.945906e-03 | 1 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 11 | 4.110144e-03 | 1 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 19 | 4.167790e-03 | 1 |
| HPA | HPA:0271131 | Kidney; distal tubules[≥Low] | Kidney; distal tubules[≥Low] | 8 | 4.373402e-03 | 1 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 21 | 4.451355e-03 | 1 |
| HPA | HPA:0390000 | Prostate | Prostate | 21 | 4.451355e-03 | 1 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 21 | 4.507905e-03 | 1 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 21 | 4.507905e-03 | 1 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 8 | 4.651305e-03 | 1 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 8 | 4.747195e-03 | 1 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 14 | 4.939567e-03 | 1 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 21 | 5.209405e-03 | 1 |
| HPA | HPA:0461481 | Skin 1; sebaceous glands[≥Low] | Skin 1; sebaceous glands[≥Low] | 5 | 5.334101e-03 | 1 |
| HPA | HPA:0271112 | Kidney; bowman's capsule[≥Medium] | Kidney; bowman's capsule[≥Medium] | 5 | 5.462110e-03 | 1 |
| HPA | HPA:0271141 | Kidney; proximal tubules (cell body)[≥Low] | Kidney; proximal tubules (cell body)[≥Low] | 8 | 5.576309e-03 | 1 |
| HPA | HPA:0130893 | Colon; goblet cells[High] | Colon; goblet cells[High] | 5 | 5.725298e-03 | 1 |
| HPA | HPA:0150893 | Duodenum; goblet cells[High] | Duodenum; goblet cells[High] | 5 | 5.998255e-03 | 1 |
| HPA | HPA:0530000 | Spleen | Spleen | 20 | 6.449804e-03 | 1 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 9 | 6.531279e-03 | 1 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 6 | 6.635699e-03 | 1 |
| HPA | HPA:0400893 | Rectum; goblet cells[High] | Rectum; goblet cells[High] | 5 | 6.725054e-03 | 1 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 18 | 6.784884e-03 | 1 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 19 | 6.900210e-03 | 1 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 21 | 6.979368e-03 | 1 |
| HPA | HPA:0131303 | Colon; enterocytes[High] | Colon; enterocytes[High] | 5 | 7.518558e-03 | 1 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 19 | 7.627086e-03 | 1 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 14 | 8.261954e-03 | 1 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 20 | 8.599697e-03 | 1 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 7 | 8.604519e-03 | 1 |
| HPA | HPA:0401303 | Rectum; enterocytes[High] | Rectum; enterocytes[High] | 5 | 9.322635e-03 | 1 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 19 | 9.453732e-03 | 1 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 21 | 9.456166e-03 | 1 |
| HPA | HPA:0031293 | Appendix; endocrine cells[High] | Appendix; endocrine cells[High] | 5 | 9.519990e-03 | 1 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 21 | 1.017198e-02 | 1 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 7 | 1.042520e-02 | 1 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 17 | 1.054700e-02 | 1 |
| HPA | HPA:0151303 | Duodenum; enterocytes[High] | Duodenum; enterocytes[High] | 5 | 1.077316e-02 | 1 |
| HPA | HPA:0271113 | Kidney; bowman's capsule[High] | Kidney; bowman's capsule[High] | 4 | 1.095625e-02 | 1 |
| HPA | HPA:0570761 | Testis; pachytene spermatocytes[≥Low] | Testis; pachytene spermatocytes[≥Low] | 13 | 1.191923e-02 | 1 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 11 | 1.194109e-02 | 1 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 7 | 1.268822e-02 | 1 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 17 | 1.291551e-02 | 1 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 20 | 1.308126e-02 | 1 |
| HPA | HPA:0481303 | Small intestine; enterocytes[High] | Small intestine; enterocytes[High] | 5 | 1.339929e-02 | 1 |
| HPA | HPA:0461421 | Skin 1; eccrine glands[≥Low] | Skin 1; eccrine glands[≥Low] | 5 | 1.366052e-02 | 1 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 17 | 1.405130e-02 | 1 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 21 | 1.433668e-02 | 1 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 20 | 1.466082e-02 | 1 |
| HPA | HPA:0131293 | Colon; endocrine cells[High] | Colon; endocrine cells[High] | 5 | 1.474509e-02 | 1 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 18 | 1.478802e-02 | 1 |
| HPA | HPA:0151352 | Duodenum; paneth cells[≥Medium] | Duodenum; paneth cells[≥Medium] | 5 | 1.531173e-02 | 1 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 8 | 1.555176e-02 | 1 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 13 | 1.592989e-02 | 1 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 21 | 1.754710e-02 | 1 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 21 | 1.754710e-02 | 1 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 16 | 1.765157e-02 | 1 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 20 | 1.771609e-02 | 1 |
| HPA | HPA:0570731 | Testis; Leydig cells[≥Low] | Testis; Leydig cells[≥Low] | 21 | 1.878009e-02 | 1 |
| HPA | HPA:0401293 | Rectum; endocrine cells[High] | Rectum; endocrine cells[High] | 5 | 2.047440e-02 | 1 |
| HPA | HPA:0050000 | Breast | Breast | 21 | 2.087705e-02 | 1 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 20 | 2.104409e-02 | 1 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 21 | 2.162428e-02 | 1 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 8 | 2.285202e-02 | 1 |
| HPA | HPA:0151351 | Duodenum; paneth cells[≥Low] | Duodenum; paneth cells[≥Low] | 5 | 2.432313e-02 | 1 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 6 | 2.593254e-02 | 1 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 17 | 2.604258e-02 | 1 |
| HPA | HPA:0481353 | Small intestine; paneth cells[High] | Small intestine; paneth cells[High] | 4 | 2.779952e-02 | 1 |
| HPA | HPA:0481293 | Small intestine; endocrine cells[High] | Small intestine; endocrine cells[High] | 5 | 2.824231e-02 | 1 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 21 | 2.925784e-02 | 1 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 21 | 2.925784e-02 | 1 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 6 | 2.955985e-02 | 1 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 19 | 3.229791e-02 | 1 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 21 | 3.245306e-02 | 1 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 21 | 3.245306e-02 | 1 |
| HPA | HPA:0300000 | Lung | Lung | 21 | 3.597890e-02 | 1 |
| HPA | HPA:0151293 | Duodenum; endocrine cells[High] | Duodenum; endocrine cells[High] | 5 | 3.638932e-02 | 1 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 16 | 3.708726e-02 | 1 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 9 | 3.716770e-02 | 1 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 12 | 3.723660e-02 | 1 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 18 | 3.821325e-02 | 1 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 21 | 3.952894e-02 | 1 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 15 | 3.962467e-02 | 1 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 14 | 3.968791e-02 | 1 |
| HPA | HPA:0360053 | Parathyroid gland; glandular cells[High] | Parathyroid gland; glandular cells[High] | 10 | 4.019516e-02 | 1 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 21 | 4.020925e-02 | 1 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 21 | 4.101703e-02 | 1 |
| HPA | HPA:0030892 | Appendix; goblet cells[≥Medium] | Appendix; goblet cells[≥Medium] | 5 | 4.295796e-02 | 1 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 21 | 4.304364e-02 | 1 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 20 | 4.348551e-02 | 1 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 9 | 4.446786e-02 | 1 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 16 | 4.549473e-02 | 1 |
| HPA | HPA:0291163 | Liver; cholangiocytes[High] | Liver; cholangiocytes[High] | 5 | 4.827799e-02 | 1 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1990542 | mitochondrial transmembrane transport | "The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899] | 6 | 0.000001 | 1 |
| GO:BP | GO:1902600 | proton transmembrane transport | "The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] | 7 | 0.000001 | 1 |
| GO:BP | GO:0055085 | transmembrane transport | "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid] | 12 | 0.000030 | 1 |
| GO:BP | GO:0006839 | mitochondrial transport | "Transport of substances into, out of or within a mitochondrion." [GOC:ai] | 6 | 0.000047 | 1 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah] | 10 | 0.000089 | 1 |
| GO:BP | GO:0009060 | aerobic respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] | 6 | 0.000092 | 1 |
| GO:BP | GO:0098662 | inorganic cation transmembrane transport | "A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] | 9 | 0.000220 | 1 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | "The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw] | 9 | 0.000276 | 1 |
| GO:BP | GO:0045333 | cellular respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732] | 6 | 0.000293 | 1 |
| GO:BP | GO:0007005 | mitochondrion organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] | 7 | 0.000445 | 1 |
| GO:BP | GO:0098660 | inorganic ion transmembrane transport | "The process in which an inorganic ion is transported across a membrane." [GOC:mah] | 9 | 0.000516 | 1 |
| GO:BP | GO:0006811 | monoatomic ion transport | "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai] | 10 | 0.000590 | 1 |
| GO:BP | GO:0006119 | oxidative phosphorylation | "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309] | 5 | 0.000716 | 1 |
| GO:BP | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis | "The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force)." [GOC:vw] | 4 | 0.001245 | 1 |
| GO:BP | GO:0006812 | monoatomic cation transport | "The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai] | 9 | 0.001468 | 1 |
| GO:BP | GO:0015986 | proton motive force-driven ATP synthesis | "The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force)." [GOC:vw] | 4 | 0.002298 | 1 |
| GO:BP | GO:0015980 | energy derivation by oxidation of organic compounds | "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] | 6 | 0.002328 | 1 |
| GO:BP | GO:0045041 | protein import into mitochondrial intermembrane space | "The import of proteins into the space between the inner and outer mitochondrial membranes." [ISBN:0716731363] | 2 | 0.005362 | 1 |
| GO:BP | GO:0006754 | ATP biosynthetic process | "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732] | 4 | 0.006728 | 1 |
| GO:BP | GO:0006810 | transport | "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] | 15 | 0.008748 | 1 |
| GO:BP | GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.010113 | 1 |
| GO:BP | GO:0009145 | purine nucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.010473 | 1 |
| GO:BP | GO:0009201 | ribonucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.012418 | 1 |
| GO:BP | GO:0006091 | generation of precursor metabolites and energy | "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] | 6 | 0.015189 | 1 |
| GO:BP | GO:0009142 | nucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.016068 | 1 |
| GO:BP | GO:0051234 | establishment of localization | "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] | 15 | 0.037153 | 1 |
| GO:BP | GO:0009152 | purine ribonucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.040903 | 1 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism | "Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722] | 4 | 0.000001 | 1 |
| GO:MF | GO:0015252 | proton channel activity | "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] | 4 | 0.000009 | 1 |
| GO:MF | GO:0015078 | proton transmembrane transporter activity | "Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai] | 6 | 0.000017 | 1 |
| GO:MF | GO:0015075 | monoatomic ion transmembrane transporter activity | "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] | 8 | 0.001038 | 1 |
| GO:MF | GO:0046625 | sphingolipid binding | "Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732] | 3 | 0.001252 | 1 |
| GO:MF | GO:0043532 | angiostatin binding | "Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis." [PMID:16043488] | 2 | 0.002516 | 1 |
| GO:MF | GO:0016491 | oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-] | 7 | 0.004989 | 1 |
| GO:MF | GO:0003985 | acetyl-CoA C-acetyltransferase activity | "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [RHEA:21036] | 2 | 0.006281 | 1 |
| GO:MF | GO:0015288 | porin activity | "Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-] | 2 | 0.006281 | 1 |
| GO:MF | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity | "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+." [EC:1.1.1.35] | 2 | 0.006281 | 1 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 11 | 0.007636 | 1 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 11 | 0.008200 | 1 |
| GO:MF | GO:0005216 | monoatomic ion channel activity | "Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] | 6 | 0.008781 | 1 |
| GO:MF | GO:0016453 | C-acetyltransferase activity | "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule." [GOC:ai] | 2 | 0.008787 | 1 |
| GO:MF | GO:0003988 | acetyl-CoA C-acyltransferase activity | "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [RHEA:21564] | 2 | 0.008787 | 1 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 11 | 0.013683 | 1 |
| GO:MF | GO:0022857 | transmembrane transporter activity | "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] | 8 | 0.013690 | 1 |
| GO:MF | GO:0016874 | ligase activity | "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-] | 4 | 0.014608 | 1 |
| GO:MF | GO:0015267 | channel activity | "Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729] | 6 | 0.016173 | 1 |
| GO:MF | GO:0022803 | passive transmembrane transporter activity | "Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] | 6 | 0.016173 | 1 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 11 | 0.021603 | 1 |
| GO:MF | GO:0005215 | transporter activity | "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells." [GOC:ai, GOC:dgf] | 8 | 0.025965 | 1 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 10 | 0.026955 | 1 |
| GO:MF | GO:0004300 | enoyl-CoA hydratase activity | "Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O." [EC:4.2.1.17] | 2 | 0.032504 | 1 |
| GO:MF | GO:0022890 | inorganic cation transmembrane transporter activity | "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] | 6 | 0.035234 | 1 |
| GO:MF | GO:0008324 | monoatomic cation transmembrane transporter activity | "Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] | 6 | 0.047413 | 1 |
| GO:MF | GO:0008142 | oxysterol binding | "Binding to oxysterol, an oxidized form of cholesterol." [GOC:curators] | 2 | 0.049903 | 1 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05415 | Diabetic cardiomyopathy | Diabetic cardiomyopathy | 7 | 0.000004 | 1 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | Chemical carcinogenesis - reactive oxygen species | 7 | 0.000007 | 1 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 7 | 0.000024 | 1 |
| KEGG | KEGG:05020 | Prion disease | Prion disease | 7 | 0.000028 | 1 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 7 | 0.000063 | 1 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 7 | 0.000286 | 1 |
| KEGG | KEGG:00190 | Oxidative phosphorylation | Oxidative phosphorylation | 5 | 0.000297 | 1 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 7 | 0.001185 | 1 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis | 6 | 0.002985 | 1 |
| KEGG | KEGG:04714 | Thermogenesis | Thermogenesis | 5 | 0.004238 | 1 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002151 | Increased circulating lactate concentration | Abnormally increased level of blood lactate (2-hydroxypropanoic acid). Lactate is produced from pyruvate by lactate dehydrogenase during normal metabolism. The terms lactate and lactic acid are often used interchangeably but lactate (the component measured in blood) is strictly a weak base whereas lactic acid is the corresponding acid. Lactic acidosis is often used clinically to describe elevated lactate but should be reserved for cases where there is a corresponding acidosis (pH below 7.35). | 9 | 0.000005 | 1 |
| HP | HP:0001941 | Acidosis | Abnormal acid accumulation or depletion of base. | 10 | 0.000073 | 1 |
| HP | HP:0004360 | Abnormality of acid-base homeostasis | An abnormality of the balance or maintenance of the balance of acids and bases in bodily fluids, resulting in an abnormal pH. | 10 | 0.000145 | 1 |
| HP | HP:0001987 | Hyperammonemia | An increased concentration of ammonia in the blood. | 6 | 0.000157 | 1 |
| HP | HP:0001635 | Congestive heart failure | The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction. | 7 | 0.010143 | 1 |
| HP | HP:0007067 | Distal peripheral sensory neuropathy | Peripheral sensory neuropathy affecting primarily distal sensation. | 3 | 0.010901 | 1 |
| HP | HP:0002157 | Azotemia | An increased concentration of nitrogen compounds in the blood. | 6 | 0.013070 | 1 |
| HP | HP:0025145 | Rigors | Severe chills with violent shivering. A rigor is an episode of shaking or exaggerated shivering which can occur with a high fever. | 2 | 0.014094 | 1 |
| HP | HP:0003128 | Lactic acidosis | An abnormal buildup of lactic acid in the body, leading to acidification of the blood and other bodily fluids. | 6 | 0.018083 | 1 |
| HP | HP:0004364 | Abnormal circulating nitrogen compound concentration | Any deviation from the normal concentration of a nitrogen compound in the blood circulation. | 6 | 0.019253 | 1 |
| HP | HP:0002490 | Increased CSF lactate | Increased concentration of lactate in the cerebrospinal fluid. | 5 | 0.019837 | 1 |
| HP | HP:0030085 | Abnormal CSF lactate concentration | Abnormal concentration of lactate in the cerebrospinal fluid. | 5 | 0.019837 | 1 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP111 | Electron transport chain OXPHOS system in mitochondria | Electron transport chain OXPHOS system in mitochondria | 5 | 0.000319 | 1 |
| WP | WP:WP623 | Oxidative phosphorylation | Oxidative phosphorylation | 4 | 0.001041 | 1 |
| WP | WP:WP4932 | 7q11 23 copy number variation syndrome | 7q11 23 copy number variation syndrome | 4 | 0.010329 | 1 |
| WP | WP:WP5504 | Disorders of mitochondrial homeostatis dynamics protein import and quality control | Disorders of mitochondrial homeostatis dynamics protein import and quality control | 3 | 0.041911 | 1 |
| WP | WP:WP3871 | Valproic acid pathway | Valproic acid pathway | 2 | 0.042285 | 1 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M03562_1 | Factor: RAR-gamma; motif: TGACCTBYNKN; match class: 1 | Factor: RAR-gamma; motif: TGACCTBYNKN; match class: 1 | 8 | 0.000408 | 1 |
| TF | TF:M10119 | Factor: REX-1; motif: GGCMGCCATTTT | Factor: REX-1; motif: GGCMGCCATTTT | 11 | 0.005441 | 1 |
| TF | TF:M06646 | Factor: znf607; motif: NGGATCAAGAAA | Factor: znf607; motif: NGGATCAAGAAA | 2 | 0.007227 | 1 |
| TF | TF:M11808 | Factor: RAR-gamma; motif: NAGGTCANG | Factor: RAR-gamma; motif: NAGGTCANG | 11 | 0.009757 | 1 |
| TF | TF:M08206 | Factor: E2F-3:Prrxl1; motif: SGCGCTAATTNN | Factor: E2F-3:Prrxl1; motif: SGCGCTAATTNN | 23 | 0.014883 | 1 |
| TF | TF:M10045 | Factor: RAR-gamma; motif: RGGTCANNNTGNCCNNNN | Factor: RAR-gamma; motif: RGGTCANNNTGNCCNNNN | 19 | 0.021264 | 1 |
| TF | TF:M11772_1 | Factor: NURR1; motif: NAAAGGTCAN; match class: 1 | Factor: NURR1; motif: NAAAGGTCAN; match class: 1 | 5 | 0.022817 | 1 |
| TF | TF:M11427 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 22 | 0.028245 | 1 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7262 | 3-Hydroxyacyl CoA dehydrogenase | 3-Hydroxyacyl CoA dehydrogenase | 2 | 0.005013 | 1 |
| CORUM | CORUM:6289 | prohibitin 2 complex, mitochondrial | prohibitin 2 complex, mitochondrial | 2 | 0.049803 | 1 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 5 | 0.034674 | 1 |
Community 2
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 17 | 1.249972e-11 | 2 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 17 | 1.579163e-11 | 2 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 17 | 1.591423e-11 | 2 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 17 | 1.591423e-11 | 2 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 18 | 9.885065e-10 | 2 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 18 | 2.937450e-08 | 2 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 18 | 7.463765e-08 | 2 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 7 | 2.239569e-05 | 2 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 7 | 2.621742e-05 | 2 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 16 | 6.217896e-04 | 2 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 4 | 8.241098e-04 | 2 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 4 | 8.241098e-04 | 2 |
| GO:CC | GO:0140534 | endoplasmic reticulum protein-containing complex | "A protein complex that is part of an endoplasmic reticulum." [GOC:pg] | 4 | 8.831496e-04 | 2 |
| GO:CC | GO:0005790 | smooth endoplasmic reticulum | "The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732] | 3 | 9.070526e-04 | 2 |
| GO:CC | GO:0005788 | endoplasmic reticulum lumen | "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] | 5 | 2.145323e-03 | 2 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 7 | 3.532295e-03 | 2 |
| GO:CC | GO:0042824 | MHC class I peptide loading complex | "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934] | 2 | 6.138505e-03 | 2 |
| GO:CC | GO:0033018 | sarcoplasmic reticulum lumen | "The volume enclosed by the membranes of the sarcoplasmic reticulum." [GOC:rph] | 2 | 7.668513e-03 | 2 |
| GO:CC | GO:0034663 | endoplasmic reticulum chaperone complex | "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] | 2 | 9.366986e-03 | 2 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 21 | 1.160107e-02 | 2 |
| GO:CC | GO:0009986 | cell surface | "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] | 6 | 3.731988e-02 | 2 |
| GO:CC | GO:0071682 | endocytic vesicle lumen | "The volume enclosed by the membrane of an endocytic vesicle." [GOC:pde] | 2 | 4.277806e-02 | 2 |
| GO:CC | GO:0031430 | M band | "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194] | 2 | 4.663891e-02 | 2 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4628 | Aerobic glycolysis augmented | Aerobic glycolysis augmented | 4 | 0.000002 | 2 |
| WP | WP:WP534 | Glycolysis and gluconeogenesis | Glycolysis and gluconeogenesis | 4 | 0.000325 | 2 |
| WP | WP:WP1946 | Cori cycle | Cori cycle | 3 | 0.000841 | 2 |
| WP | WP:WP4018 | Clear cell renal cell carcinoma pathways | Clear cell renal cell carcinoma pathways | 4 | 0.004177 | 2 |
| WP | WP:WP5355 | Metabolic epileptic disorders | Metabolic epileptic disorders | 4 | 0.005469 | 2 |
| WP | WP:WP4290 | Metabolic reprogramming in colon cancer | Metabolic reprogramming in colon cancer | 3 | 0.013722 | 2 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 6 | 0.030988 | 2 |
| WP | WP:WP5049 | Glycolysis in senescence | Glycolysis in senescence | 2 | 0.035283 | 2 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 12 | 0.000009 | 2 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 11 | 0.000009 | 2 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 11 | 0.000013 | 2 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 11 | 0.000023 | 2 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 11 | 0.000056 | 2 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 8 | 0.000205 | 2 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 10 | 0.000241 | 2 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 10 | 0.000288 | 2 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 19 | 0.001721 | 2 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 8 | 0.002082 | 2 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 7 | 0.002329 | 2 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 8 | 0.002335 | 2 |
| HPA | HPA:0271122 | Kidney; collecting ducts[≥Medium] | Kidney; collecting ducts[≥Medium] | 7 | 0.002572 | 2 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 9 | 0.002732 | 2 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 8 | 0.004747 | 2 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 19 | 0.004934 | 2 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 10 | 0.005584 | 2 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 11 | 0.005727 | 2 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 17 | 0.005906 | 2 |
| HPA | HPA:0530000 | Spleen | Spleen | 20 | 0.006450 | 2 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 17 | 0.007117 | 2 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 8 | 0.007184 | 2 |
| HPA | HPA:0471482 | Skin 2; sebaceous glands[≥Medium] | Skin 2; sebaceous glands[≥Medium] | 4 | 0.008325 | 2 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 17 | 0.009851 | 2 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 8 | 0.009861 | 2 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 7 | 0.010425 | 2 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 17 | 0.010547 | 2 |
| HPA | HPA:0271121 | Kidney; collecting ducts[≥Low] | Kidney; collecting ducts[≥Low] | 7 | 0.013384 | 2 |
| HPA | HPA:0340000 | Ovary | Ovary | 19 | 0.014622 | 2 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 8 | 0.015552 | 2 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 12 | 0.016930 | 2 |
| HPA | HPA:0471481 | Skin 2; sebaceous glands[≥Low] | Skin 2; sebaceous glands[≥Low] | 4 | 0.016954 | 2 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 7 | 0.020566 | 2 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 18 | 0.021748 | 2 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 7 | 0.025435 | 2 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 20 | 0.025782 | 2 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 19 | 0.026199 | 2 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 7 | 0.030927 | 2 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 16 | 0.031706 | 2 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 16 | 0.031706 | 2 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 19 | 0.032298 | 2 |
| HPA | HPA:0031301 | Appendix; enterocytes[≥Low] | Appendix; enterocytes[≥Low] | 6 | 0.033967 | 2 |
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 16 | 0.034301 | 2 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 7 | 0.035732 | 2 |
| HPA | HPA:0010012 | Adipose tissue; adipocytes[≥Medium] | Adipose tissue; adipocytes[≥Medium] | 12 | 0.037403 | 2 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 7 | 0.041488 | 2 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 18 | 0.044396 | 2 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 7 | 0.044447 | 2 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:01230 | Biosynthesis of amino acids | Biosynthesis of amino acids | 5 | 0.000015 | 2 |
| KEGG | KEGG:01200 | Carbon metabolism | Carbon metabolism | 5 | 0.000139 | 2 |
| KEGG | KEGG:00010 | Glycolysis / Gluconeogenesis | Glycolysis / Gluconeogenesis | 4 | 0.000479 | 2 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 4 | 0.017665 | 2 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-70263 | Gluconeogenesis | Gluconeogenesis | 4 | 0.000028 | 2 |
| REAC | REAC:R-HSA-9636667 | Manipulation of host energy metabolism | Manipulation of host energy metabolism | 2 | 0.001068 | 2 |
| REAC | REAC:R-HSA-70171 | Glycolysis | Glycolysis | 4 | 0.002040 | 2 |
| REAC | REAC:R-HSA-70326 | Glucose metabolism | Glucose metabolism | 4 | 0.003355 | 2 |
| REAC | REAC:R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | ATF6 (ATF6-alpha) activates chaperone genes | 2 | 0.038138 | 2 |
| REAC | REAC:R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | Metabolism of carbohydrates and carbohydrate derivatives | 5 | 0.038992 | 2 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 8 | 0.000069 | 2 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 6 | 0.000129 | 2 |
| GO:BP | GO:0034975 | protein folding in endoplasmic reticulum | "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw] | 3 | 0.000362 | 2 |
| GO:BP | GO:0046496 | nicotinamide nucleotide metabolic process | "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] | 5 | 0.001008 | 2 |
| GO:BP | GO:0019362 | pyridine nucleotide metabolic process | "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] | 5 | 0.001008 | 2 |
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 5 | 0.001242 | 2 |
| GO:BP | GO:0061621 | canonical glycolysis | "The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479] | 3 | 0.001338 | 2 |
| GO:BP | GO:0061718 | glucose catabolic process to pyruvate | "The chemical reactions and pathways resulting in the breakdown of glucose, with the production of pyruvate." [GOC:dph] | 3 | 0.001338 | 2 |
| GO:BP | GO:0061620 | glycolytic process through glucose-6-phosphate | "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479] | 3 | 0.001867 | 2 |
| GO:BP | GO:0061615 | glycolytic process through fructose-6-phosphate | "The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479] | 3 | 0.003306 | 2 |
| GO:BP | GO:0006007 | glucose catabolic process | "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] | 3 | 0.004241 | 2 |
| GO:BP | GO:0006096 | glycolytic process | "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] | 4 | 0.004479 | 2 |
| GO:BP | GO:0046032 | ADP catabolic process | "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators] | 4 | 0.004868 | 2 |
| GO:BP | GO:0019364 | pyridine nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw] | 4 | 0.005282 | 2 |
| GO:BP | GO:0009181 | purine ribonucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.005498 | 2 |
| GO:BP | GO:0009137 | purine nucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.005498 | 2 |
| GO:BP | GO:0072526 | pyridine-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 4 | 0.005950 | 2 |
| GO:BP | GO:0009191 | ribonucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.006186 | 2 |
| GO:BP | GO:0046031 | ADP metabolic process | "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators] | 4 | 0.006430 | 2 |
| GO:BP | GO:0009134 | nucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.007201 | 2 |
| GO:BP | GO:0006734 | NADH metabolic process | "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] | 3 | 0.009709 | 2 |
| GO:BP | GO:0009135 | purine nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.009930 | 2 |
| GO:BP | GO:0009179 | purine ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.009930 | 2 |
| GO:BP | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai] | 2 | 0.010438 | 2 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 5 | 0.012349 | 2 |
| GO:BP | GO:0006090 | pyruvate metabolic process | "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] | 4 | 0.012939 | 2 |
| GO:BP | GO:0009185 | ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.013786 | 2 |
| GO:BP | GO:0009154 | purine ribonucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.015132 | 2 |
| GO:BP | GO:0009132 | nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.017076 | 2 |
| GO:BP | GO:0009261 | ribonucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.018650 | 2 |
| GO:BP | GO:0006195 | purine nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 0.019757 | 2 |
| GO:BP | GO:0019320 | hexose catabolic process | "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] | 3 | 0.024430 | 2 |
| GO:BP | GO:0002502 | peptide antigen assembly with MHC class I protein complex | "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] | 2 | 0.026061 | 2 |
| GO:BP | GO:0002397 | MHC class I protein complex assembly | "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] | 2 | 0.026061 | 2 |
| GO:BP | GO:0072523 | purine-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 4 | 0.031230 | 2 |
| GO:BP | GO:0046365 | monosaccharide catabolic process | "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] | 3 | 0.031458 | 2 |
| GO:BP | GO:0051017 | actin filament bundle assembly | "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] | 4 | 0.035381 | 2 |
| GO:BP | GO:0009166 | nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] | 4 | 0.037150 | 2 |
| GO:BP | GO:0061572 | actin filament bundle organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] | 4 | 0.038058 | 2 |
| GO:BP | GO:0016052 | carbohydrate catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] | 4 | 0.048066 | 2 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016860 | intramolecular oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators] | 4 | 0.000120 | 2 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 11 | 0.001163 | 2 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 4 | 0.002022 | 2 |
| GO:MF | GO:0015035 | protein-disulfide reductase activity | "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385] | 3 | 0.002117 | 2 |
| GO:MF | GO:0016853 | isomerase activity | "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] | 6 | 0.002142 | 2 |
| GO:MF | GO:0015036 | disulfide oxidoreductase activity | "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [GOC:curators] | 3 | 0.003480 | 2 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 12 | 0.007331 | 2 |
| GO:MF | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors | "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.8.-.-, GOC:ai] | 3 | 0.009144 | 2 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 3 | 0.017309 | 2 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 8 | 0.038864 | 2 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 8 | 0.047081 | 2 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M08225_1 | Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 | Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 | 20 | 0.003013 | 2 |
| TF | TF:M00695_1 | Factor: ETF; motif: GVGGMGG; match class: 1 | Factor: ETF; motif: GVGGMGG; match class: 1 | 18 | 0.029293 | 2 |
| TF | TF:M07395_1 | Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 | Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 | 17 | 0.048367 | 2 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0012438 | Abnormal gallbladder physiology | A functional anomaly of the gallbladder. | 3 | 0.003687 | 2 |
| HP | HP:0001082 | Cholecystitis | The presence of inflammatory changes in the gallbladder. | 3 | 0.003687 | 2 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5217 | Calreticulin homo-oligomer complex | Calreticulin homo-oligomer complex | 1 | 0.04968 | 2 |
Community 3
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 15 | 1.181944e-17 | 3 |
| GO:CC | GO:0030863 | cortical cytoskeleton | "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] | 9 | 2.162465e-13 | 3 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 11 | 7.049686e-13 | 3 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 18 | 5.913835e-12 | 3 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 13 | 5.764356e-11 | 3 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 10 | 5.967315e-10 | 3 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 10 | 7.506565e-10 | 3 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 16 | 2.484656e-09 | 3 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 12 | 1.116628e-08 | 3 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 12 | 1.217558e-08 | 3 |
| GO:CC | GO:0042641 | actomyosin | "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] | 6 | 5.978789e-08 | 3 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 12 | 3.706739e-07 | 3 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 19 | 4.379204e-07 | 3 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 14 | 9.259928e-07 | 3 |
| GO:CC | GO:0030864 | cortical actin cytoskeleton | "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] | 5 | 3.360490e-06 | 3 |
| GO:CC | GO:0032432 | actin filament bundle | "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] | 5 | 5.898030e-06 | 3 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 19 | 1.251277e-05 | 3 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 19 | 1.254626e-05 | 3 |
| GO:CC | GO:0030016 | myofibril | "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] | 6 | 1.783939e-05 | 3 |
| GO:CC | GO:0005884 | actin filament | "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] | 5 | 2.160347e-05 | 3 |
| GO:CC | GO:0043292 | contractile muscle fiber | "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] | 6 | 2.270634e-05 | 3 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 7 | 9.315003e-05 | 3 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 8 | 1.273020e-04 | 3 |
| GO:CC | GO:0001725 | stress fiber | "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] | 4 | 2.670873e-04 | 3 |
| GO:CC | GO:0097517 | contractile actin filament bundle | "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194] | 4 | 2.670873e-04 | 3 |
| GO:CC | GO:0098590 | plasma membrane region | "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] | 9 | 4.432122e-04 | 3 |
| GO:CC | GO:0031252 | cell leading edge | "The area of a motile cell closest to the direction of movement." [GOC:pg] | 6 | 5.609214e-04 | 3 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 17 | 5.810879e-04 | 3 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 22 | 6.471428e-04 | 3 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 11 | 7.040945e-04 | 3 |
| GO:CC | GO:0005903 | brush border | "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] | 4 | 7.148563e-04 | 3 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 16 | 1.415397e-03 | 3 |
| GO:CC | GO:0002102 | podosome | "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] | 3 | 1.608577e-03 | 3 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 10 | 2.427545e-03 | 3 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 10 | 2.751825e-03 | 3 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 10 | 2.763255e-03 | 3 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 10 | 2.763255e-03 | 3 |
| GO:CC | GO:0032154 | cleavage furrow | "The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409] | 3 | 3.923316e-03 | 3 |
| GO:CC | GO:0098862 | cluster of actin-based cell projections | "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos] | 4 | 4.187100e-03 | 3 |
| GO:CC | GO:0016459 | myosin complex | "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin] | 3 | 4.605466e-03 | 3 |
| GO:CC | GO:0071439 | clathrin complex | "A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface." [GOC:mah, PMID:16493411] | 2 | 4.777268e-03 | 3 |
| GO:CC | GO:0001726 | ruffle | "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] | 4 | 5.453511e-03 | 3 |
| GO:CC | GO:0008091 | spectrin | "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194] | 2 | 6.138505e-03 | 3 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 8 | 7.830436e-03 | 3 |
| GO:CC | GO:0032153 | cell division site | "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305] | 3 | 9.576331e-03 | 3 |
| GO:CC | GO:0030017 | sarcomere | "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] | 4 | 1.056434e-02 | 3 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 19 | 1.318140e-02 | 3 |
| GO:CC | GO:1990498 | mitotic spindle microtubule | "Any microtubule that is part of a mitotic spindle; anchored at one spindle pole." [GOC:vw] | 2 | 2.037564e-02 | 3 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 8 | 2.239514e-02 | 3 |
| GO:CC | GO:0005802 | trans-Golgi network | "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] | 4 | 2.347738e-02 | 3 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 12 | 2.486630e-02 | 3 |
| GO:CC | GO:0150034 | distal axon | "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] | 4 | 2.816485e-02 | 3 |
| GO:CC | GO:0030132 | clathrin coat of coated pit | "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah] | 2 | 2.898291e-02 | 3 |
| GO:CC | GO:0030130 | clathrin coat of trans-Golgi network vesicle | "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah] | 2 | 2.898291e-02 | 3 |
| GO:CC | GO:0036020 | endolysosome membrane | "The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde] | 2 | 3.218386e-02 | 3 |
| GO:CC | GO:0012510 | trans-Golgi network transport vesicle membrane | "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai] | 2 | 3.555024e-02 | 3 |
| GO:CC | GO:0043005 | neuron projection | "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] | 7 | 4.334335e-02 | 3 |
| GO:CC | GO:0032982 | myosin filament | "A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah] | 2 | 4.663891e-02 | 3 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 14 | 4.034500e-16 | 3 |
| GO:MF | GO:0051015 | actin filament binding | "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] | 11 | 2.257726e-14 | 3 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 15 | 9.312577e-13 | 3 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 9 | 1.116410e-08 | 3 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 13 | 3.183918e-08 | 3 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 9 | 1.108216e-06 | 3 |
| GO:MF | GO:0005516 | calmodulin binding | "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] | 5 | 8.089202e-04 | 3 |
| GO:MF | GO:0051020 | GTPase binding | "Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai] | 5 | 6.263571e-03 | 3 |
| GO:MF | GO:0005522 | profilin binding | "Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544] | 2 | 1.638167e-02 | 3 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 6 | 2.878202e-02 | 3 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 17 | 1.263792e-12 | 3 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 14 | 1.322864e-12 | 3 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 14 | 7.323988e-12 | 3 |
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 12 | 9.462971e-12 | 3 |
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 13 | 4.905269e-10 | 3 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 11 | 1.646022e-09 | 3 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] | 10 | 2.643683e-09 | 3 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 17 | 2.811350e-09 | 3 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 10 | 3.174557e-09 | 3 |
| GO:BP | GO:0110053 | regulation of actin filament organization | "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv] | 9 | 4.702073e-09 | 3 |
| GO:BP | GO:0030834 | regulation of actin filament depolymerization | "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] | 6 | 2.308657e-08 | 3 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] | 9 | 3.998831e-08 | 3 |
| GO:BP | GO:0030042 | actin filament depolymerization | "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] | 6 | 4.057016e-08 | 3 |
| GO:BP | GO:0051261 | protein depolymerization | "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] | 7 | 4.640640e-08 | 3 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 18 | 9.041594e-08 | 3 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 12 | 4.295568e-07 | 3 |
| GO:BP | GO:1901879 | regulation of protein depolymerization | "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] | 6 | 6.538625e-07 | 3 |
| GO:BP | GO:0030835 | negative regulation of actin filament depolymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah] | 5 | 1.356376e-06 | 3 |
| GO:BP | GO:0031032 | actomyosin structure organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] | 7 | 2.398349e-06 | 3 |
| GO:BP | GO:0043244 | regulation of protein-containing complex disassembly | "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] | 6 | 5.192967e-06 | 3 |
| GO:BP | GO:0032984 | protein-containing complex disassembly | "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah] | 7 | 9.130030e-06 | 3 |
| GO:BP | GO:0008064 | regulation of actin polymerization or depolymerization | "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] | 6 | 1.195128e-05 | 3 |
| GO:BP | GO:0030832 | regulation of actin filament length | "Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah] | 6 | 1.349314e-05 | 3 |
| GO:BP | GO:0051494 | negative regulation of cytoskeleton organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 6 | 1.642738e-05 | 3 |
| GO:BP | GO:0032272 | negative regulation of protein polymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 5 | 1.714768e-05 | 3 |
| GO:BP | GO:1902904 | negative regulation of supramolecular fiber organization | "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 6 | 1.774006e-05 | 3 |
| GO:BP | GO:1901880 | negative regulation of protein depolymerization | "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] | 5 | 1.839612e-05 | 3 |
| GO:BP | GO:0043242 | negative regulation of protein-containing complex disassembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] | 5 | 3.532051e-05 | 3 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 10 | 4.015592e-05 | 3 |
| GO:BP | GO:0008154 | actin polymerization or depolymerization | "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] | 6 | 5.722982e-05 | 3 |
| GO:BP | GO:0051693 | actin filament capping | "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] | 4 | 1.335226e-04 | 3 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 8 | 3.186700e-04 | 3 |
| GO:BP | GO:0022411 | cellular component disassembly | "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] | 7 | 3.978168e-04 | 3 |
| GO:BP | GO:0031333 | negative regulation of protein-containing complex assembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] | 5 | 5.237798e-04 | 3 |
| GO:BP | GO:0030837 | negative regulation of actin filament polymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] | 4 | 6.122648e-04 | 3 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 20 | 9.600359e-04 | 3 |
| GO:BP | GO:0022607 | cellular component assembly | "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] | 16 | 1.226578e-03 | 3 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 20 | 1.543237e-03 | 3 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 6 | 2.091904e-03 | 3 |
| GO:BP | GO:0032535 | regulation of cellular component size | "A process that modulates the size of a cellular component." [GOC:mah] | 6 | 2.233836e-03 | 3 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 16 | 2.658911e-03 | 3 |
| GO:BP | GO:0032271 | regulation of protein polymerization | "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 5 | 2.780658e-03 | 3 |
| GO:BP | GO:0016192 | vesicle-mediated transport | "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] | 10 | 2.784983e-03 | 3 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] | 6 | 5.892191e-03 | 3 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 7 | 8.154909e-03 | 3 |
| GO:BP | GO:0006897 | endocytosis | "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis] | 7 | 8.787090e-03 | 3 |
| GO:BP | GO:0030833 | regulation of actin filament polymerization | "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] | 4 | 1.467333e-02 | 3 |
| GO:BP | GO:0051258 | protein polymerization | "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] | 5 | 1.577902e-02 | 3 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb] | 6 | 1.578320e-02 | 3 |
| GO:BP | GO:1902396 | protein localization to bicellular tight junction | "A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction." [GOC:TermGenie, PMID:18332111] | 2 | 1.738487e-02 | 3 |
| GO:BP | GO:0016477 | cell migration | "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] | 9 | 1.981851e-02 | 3 |
| GO:BP | GO:0072583 | clathrin-dependent endocytosis | "An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965] | 3 | 2.779771e-02 | 3 |
| GO:BP | GO:0051017 | actin filament bundle assembly | "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] | 4 | 3.538109e-02 | 3 |
| GO:BP | GO:0030041 | actin filament polymerization | "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] | 4 | 3.625763e-02 | 3 |
| GO:BP | GO:0061572 | actin filament bundle organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] | 4 | 3.805850e-02 | 3 |
| GO:BP | GO:0098657 | import into cell | "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos] | 7 | 4.854345e-02 | 3 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | Sensory processing of sound by outer hair cells of the cochlea | 5 | 0.000004 | 3 |
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 10 | 0.000004 | 3 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 10 | 0.000005 | 3 |
| REAC | REAC:R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | Sensory processing of sound by inner hair cells of the cochlea | 5 | 0.000013 | 3 |
| REAC | REAC:R-HSA-9659379 | Sensory processing of sound | Sensory processing of sound | 5 | 0.000023 | 3 |
| REAC | REAC:R-HSA-9013424 | RHOV GTPase cycle | RHOV GTPase cycle | 4 | 0.000083 | 3 |
| REAC | REAC:R-HSA-9013420 | RHOU GTPase cycle | RHOU GTPase cycle | 4 | 0.000103 | 3 |
| REAC | REAC:R-HSA-196025 | Formation of annular gap junctions | Formation of annular gap junctions | 3 | 0.000166 | 3 |
| REAC | REAC:R-HSA-190873 | Gap junction degradation | Gap junction degradation | 3 | 0.000221 | 3 |
| REAC | REAC:R-HSA-373760 | L1CAM interactions | L1CAM interactions | 5 | 0.000251 | 3 |
| REAC | REAC:R-HSA-199991 | Membrane Trafficking | Membrane Trafficking | 8 | 0.000528 | 3 |
| REAC | REAC:R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | Entry of Influenza Virion into Host Cell via Endocytosis | 2 | 0.000744 | 3 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 7 | 0.000753 | 3 |
| REAC | REAC:R-HSA-1500931 | Cell-Cell communication | Cell-Cell communication | 5 | 0.000790 | 3 |
| REAC | REAC:R-HSA-5627123 | RHO GTPases activate PAKs | RHO GTPases activate PAKs | 3 | 0.001326 | 3 |
| REAC | REAC:R-HSA-5653656 | Vesicle-mediated transport | Vesicle-mediated transport | 8 | 0.001516 | 3 |
| REAC | REAC:R-HSA-195258 | RHO GTPase Effectors | RHO GTPase Effectors | 6 | 0.001740 | 3 |
| REAC | REAC:R-HSA-373753 | Nephrin family interactions | Nephrin family interactions | 3 | 0.001762 | 3 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 7 | 0.002863 | 3 |
| REAC | REAC:R-HSA-2682334 | EPH-Ephrin signaling | EPH-Ephrin signaling | 4 | 0.003040 | 3 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 7 | 0.003850 | 3 |
| REAC | REAC:R-HSA-445095 | Interaction between L1 and Ankyrins | Interaction between L1 and Ankyrins | 3 | 0.004438 | 3 |
| REAC | REAC:R-HSA-9012999 | RHO GTPase cycle | RHO GTPase cycle | 6 | 0.012460 | 3 |
| REAC | REAC:R-HSA-5673001 | RAF/MAP kinase cascade | RAF/MAP kinase cascade | 5 | 0.012834 | 3 |
| REAC | REAC:R-HSA-5684996 | MAPK1/MAPK3 signaling | MAPK1/MAPK3 signaling | 5 | 0.014032 | 3 |
| REAC | REAC:R-HSA-437239 | Recycling pathway of L1 | Recycling pathway of L1 | 3 | 0.016804 | 3 |
| REAC | REAC:R-HSA-190828 | Gap junction trafficking | Gap junction trafficking | 3 | 0.017882 | 3 |
| REAC | REAC:R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | EPH-ephrin mediated repulsion of cells | 3 | 0.017882 | 3 |
| REAC | REAC:R-HSA-157858 | Gap junction trafficking and regulation | Gap junction trafficking and regulation | 3 | 0.019006 | 3 |
| REAC | REAC:R-HSA-5683057 | MAPK family signaling cascades | MAPK family signaling cascades | 5 | 0.026637 | 3 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 9 | 0.000298 | 3 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 10 | 0.000307 | 3 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 7 | 0.000307 | 3 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 10 | 0.000504 | 3 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 8 | 0.001895 | 3 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 9 | 0.004270 | 3 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 9 | 0.013822 | 3 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 8 | 0.016380 | 3 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 22 | 0.027371 | 3 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 22 | 0.049433 | 3 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 22 | 0.049433 | 3 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4217 | Ebola virus infection in host | Ebola virus infection in host | 5 | 0.00032 | 3 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 6 | 0.00962 | 3 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 9 | 0.000763 | 3 |
| MIRNA | MIRNA:hsa-mir-4761-3p | hsa-mir-4761-3p | hsa-mir-4761-3p | 7 | 0.014881 | 3 |
| MIRNA | MIRNA:hsa-mir-337-3p | hsa-mir-337-3p | hsa-mir-337-3p | 7 | 0.018120 | 3 |
| MIRNA | MIRNA:hsa-mir-922 | hsa-mir-922 | hsa-mir-922 | 10 | 0.034146 | 3 |
| MIRNA | MIRNA:hsa-mir-4311 | hsa-mir-4311 | hsa-mir-4311 | 9 | 0.035631 | 3 |
| MIRNA | MIRNA:hsa-mir-3922-3p | hsa-mir-3922-3p | hsa-mir-3922-3p | 8 | 0.038080 | 3 |
| MIRNA | MIRNA:hsa-mir-34a-5p | hsa-mir-34a-5p | hsa-mir-34a-5p | 6 | 0.039129 | 3 |
| MIRNA | MIRNA:hsa-mir-3176 | hsa-mir-3176 | hsa-mir-3176 | 8 | 0.040285 | 3 |
| MIRNA | MIRNA:hsa-mir-877-3p | hsa-mir-877-3p | hsa-mir-877-3p | 6 | 0.044066 | 3 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2837 | Profilin 1 complex | Profilin 1 complex | 2 | 0.007621 | 3 |
| CORUM | CORUM:5604 | Emerin complex 1 | Emerin complex 1 | 2 | 0.021262 | 3 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04814 | Motor proteins | Motor proteins | 4 | 0.008598 | 3 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | Bacterial invasion of epithelial cells | 3 | 0.010478 | 3 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | Proteoglycans in cancer | 4 | 0.010851 | 3 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 4 | 0.016054 | 3 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0000437 | Depressed nasal tip | Decreased distance from the nasal tip to the nasal base. | 3 | 0.014673 | 3 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05444_1 | Factor: CPBP; motif: NGGGCGG; match class: 1 | Factor: CPBP; motif: NGGGCGG; match class: 1 | 13 | 0.022076 | 3 |
| TF | TF:M05332_1 | Factor: Sp2; motif: WGGGCGG; match class: 1 | Factor: Sp2; motif: WGGGCGG; match class: 1 | 13 | 0.022076 | 3 |
| TF | TF:M05361_1 | Factor: Sp6; motif: WGGGCGG; match class: 1 | Factor: Sp6; motif: WGGGCGG; match class: 1 | 13 | 0.022076 | 3 |
| TF | TF:M07461_1 | Factor: KLF; motif: GGGNGGGG; match class: 1 | Factor: KLF; motif: GGGNGGGG; match class: 1 | 13 | 0.031438 | 3 |
Community 4
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 13 | 1.296121e-14 | 4 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 13 | 3.612513e-14 | 4 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 14 | 6.308994e-14 | 4 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 14 | 2.602959e-13 | 4 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 9 | 2.901648e-12 | 4 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 9 | 1.170121e-11 | 4 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 15 | 1.996588e-11 | 4 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 10 | 1.303137e-09 | 4 |
| GO:BP | GO:0033044 | regulation of chromosome organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] | 8 | 8.967824e-09 | 4 |
| GO:BP | GO:0006310 | DNA recombination | "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] | 8 | 1.594873e-07 | 4 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 6 | 3.461945e-07 | 4 |
| GO:BP | GO:0009314 | response to radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] | 8 | 9.911829e-07 | 4 |
| GO:BP | GO:0010212 | response to ionizing radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] | 6 | 1.399524e-06 | 4 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 15 | 1.692032e-06 | 4 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 14 | 1.840038e-06 | 4 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 7 | 1.893986e-06 | 4 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 14 | 3.189346e-06 | 4 |
| GO:BP | GO:0006302 | double-strand break repair | "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] | 7 | 4.350291e-06 | 4 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 14 | 4.538425e-06 | 4 |
| GO:BP | GO:0016233 | telomere capping | "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055] | 4 | 7.459501e-06 | 4 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 14 | 1.059070e-05 | 4 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 14 | 1.071029e-05 | 4 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 17 | 2.681511e-05 | 4 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 14 | 4.305910e-05 | 4 |
| GO:BP | GO:0006338 | chromatin remodeling | "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] | 8 | 5.217830e-05 | 4 |
| GO:BP | GO:0034502 | protein localization to chromosome | "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah] | 5 | 6.128956e-05 | 4 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 8 | 6.443016e-05 | 4 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 10 | 7.156983e-05 | 4 |
| GO:BP | GO:0110025 | DNA strand resection involved in replication fork processing | "The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing." [GOC:mah, PMID:28475874] | 3 | 7.719794e-05 | 4 |
| GO:BP | GO:0007093 | mitotic cell cycle checkpoint signaling | "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] | 5 | 8.989776e-05 | 4 |
| GO:BP | GO:0009628 | response to abiotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] | 9 | 9.739455e-05 | 4 |
| GO:BP | GO:0051053 | negative regulation of DNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 5 | 1.002792e-04 | 4 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 9 | 1.003696e-04 | 4 |
| GO:BP | GO:0010948 | negative regulation of cell cycle process | "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 6 | 1.026005e-04 | 4 |
| GO:BP | GO:0031297 | replication fork processing | "The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542] | 4 | 1.049634e-04 | 4 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 6 | 1.068769e-04 | 4 |
| GO:BP | GO:0010332 | response to gamma radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators] | 4 | 1.136540e-04 | 4 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 15 | 1.545960e-04 | 4 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 9 | 1.567238e-04 | 4 |
| GO:BP | GO:0045005 | DNA-templated DNA replication maintenance of fidelity | "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw] | 4 | 1.904067e-04 | 4 |
| GO:BP | GO:0006261 | DNA-templated DNA replication | "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] | 5 | 2.025655e-04 | 4 |
| GO:BP | GO:1904353 | regulation of telomere capping | "Any process that modulates the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 3 | 2.336996e-04 | 4 |
| GO:BP | GO:0006325 | chromatin organization | "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] | 8 | 2.411768e-04 | 4 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 9 | 2.557414e-04 | 4 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 8 | 2.584593e-04 | 4 |
| GO:BP | GO:0006303 | double-strand break repair via nonhomologous end joining | "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021] | 4 | 3.815079e-04 | 4 |
| GO:BP | GO:0071478 | cellular response to radiation | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:mah] | 5 | 3.846767e-04 | 4 |
| GO:BP | GO:0000075 | cell cycle checkpoint signaling | "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] | 5 | 4.172228e-04 | 4 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 8 | 4.396363e-04 | 4 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] | 8 | 4.431674e-04 | 4 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 4 | 4.522087e-04 | 4 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 6 | 4.918174e-04 | 4 |
| GO:BP | GO:0000725 | recombinational repair | "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] | 5 | 5.147820e-04 | 4 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 15 | 5.936744e-04 | 4 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 17 | 7.909929e-04 | 4 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 7 | 9.493242e-04 | 4 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 10 | 1.070877e-03 | 4 |
| GO:BP | GO:0045930 | negative regulation of mitotic cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 5 | 1.099885e-03 | 4 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 7 | 1.136418e-03 | 4 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 15 | 1.329432e-03 | 4 |
| GO:BP | GO:2001251 | negative regulation of chromosome organization | "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol] | 4 | 1.422512e-03 | 4 |
| GO:BP | GO:1901988 | negative regulation of cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 5 | 1.777149e-03 | 4 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 15 | 2.210599e-03 | 4 |
| GO:BP | GO:0010165 | response to X-ray | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] | 3 | 2.328469e-03 | 4 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 9 | 2.362003e-03 | 4 |
| GO:BP | GO:0034462 | small-subunit processome assembly | "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome." [GOC:mah] | 2 | 2.713201e-03 | 4 |
| GO:BP | GO:0180025 | cytosolic small ribosomal subunit assembly | "The aggregation, arrangement and bonding together of a set of components to form a cytosolic small ribosomal subunit." [PMID:30467428] | 2 | 2.713201e-03 | 4 |
| GO:BP | GO:0000077 | DNA damage checkpoint signaling | "A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah] | 4 | 2.716599e-03 | 4 |
| GO:BP | GO:0031570 | DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] | 4 | 3.679548e-03 | 4 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 14 | 4.065664e-03 | 4 |
| GO:BP | GO:0002218 | activation of innate immune response | "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805] | 5 | 4.902394e-03 | 4 |
| GO:BP | GO:0031860 | telomeric 3' overhang formation | "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans." [PMID:16096639] | 2 | 5.423821e-03 | 4 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 5 | 5.477043e-03 | 4 |
| GO:BP | GO:0032205 | negative regulation of telomere maintenance | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 3 | 5.794695e-03 | 4 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 9 | 5.897050e-03 | 4 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 14 | 6.471921e-03 | 4 |
| GO:BP | GO:0000018 | regulation of DNA recombination | "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732] | 4 | 6.890407e-03 | 4 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 15 | 6.891189e-03 | 4 |
| GO:BP | GO:0080134 | regulation of response to stress | "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 8 | 7.336423e-03 | 4 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 6 | 7.759814e-03 | 4 |
| GO:BP | GO:0071214 | cellular response to abiotic stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah] | 5 | 8.208482e-03 | 4 |
| GO:BP | GO:0104004 | cellular response to environmental stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus." [GOC:dos] | 5 | 8.208482e-03 | 4 |
| GO:BP | GO:0030097 | hemopoiesis | "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] | 7 | 8.629623e-03 | 4 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 5 | 9.856979e-03 | 4 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 4 | 1.153722e-02 | 4 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 8 | 1.288008e-02 | 4 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 7 | 1.302906e-02 | 4 |
| GO:BP | GO:0045089 | positive regulation of innate immune response | "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] | 5 | 1.322910e-02 | 4 |
| GO:BP | GO:1901991 | negative regulation of mitotic cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 1.392722e-02 | 4 |
| GO:BP | GO:0042770 | signal transduction in response to DNA damage | "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators] | 4 | 1.424978e-02 | 4 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 15 | 1.497159e-02 | 4 |
| GO:BP | GO:0044818 | mitotic G2/M transition checkpoint | "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 1.650216e-02 | 4 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 7 | 1.752208e-02 | 4 |
| GO:BP | GO:0002833 | positive regulation of response to biotic stimulus | "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] | 5 | 1.831490e-02 | 4 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 3 | 2.147112e-02 | 4 |
| GO:BP | GO:0022414 | reproductive process | "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] | 8 | 2.196166e-02 | 4 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 3 | 2.487909e-02 | 4 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 5 | 2.510120e-02 | 4 |
| GO:BP | GO:0097681 | double-strand break repair via alternative nonhomologous end joining | "An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment." [GOC:rph, PMID:18584027, PMID:21655080, Wikipedia:Microhomology-mediated_end_joining] | 2 | 2.526305e-02 | 4 |
| GO:BP | GO:1904354 | negative regulation of telomere capping | "Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 2 | 2.526305e-02 | 4 |
| GO:BP | GO:0016447 | somatic recombination of immunoglobulin gene segments | "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149] | 3 | 2.608961e-02 | 4 |
| GO:BP | GO:0050778 | positive regulation of immune response | "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 6 | 2.827623e-02 | 4 |
| GO:BP | GO:0007623 | circadian rhythm | "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] | 4 | 3.056387e-02 | 4 |
| GO:BP | GO:0035825 | homologous recombination | "A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules." [GOC:mah, PMID:11139492, PMID:17304215] | 3 | 3.131951e-02 | 4 |
| GO:BP | GO:0045088 | regulation of innate immune response | "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] | 5 | 3.196608e-02 | 4 |
| GO:BP | GO:0062176 | R-loop processing | "A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability." [PMID:27252122, PMID:28790157, PMID:33986538] | 2 | 3.246561e-02 | 4 |
| GO:BP | GO:0071475 | cellular hyperosmotic salinity response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah] | 2 | 3.246561e-02 | 4 |
| GO:BP | GO:0016445 | somatic diversification of immunoglobulins | "The somatic process that results in the generation of sequence diversity of immunoglobulins." [GOC:add, GOC:ma, ISBN:0781735149] | 3 | 3.272676e-02 | 4 |
| GO:BP | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 3.272676e-02 | 4 |
| GO:BP | GO:0044773 | mitotic DNA damage checkpoint signaling | "A signal transduction process involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 3.417506e-02 | 4 |
| GO:BP | GO:1902750 | negative regulation of cell cycle G2/M phase transition | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 3 | 3.566495e-02 | 4 |
| GO:BP | GO:0071479 | cellular response to ionizing radiation | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah] | 3 | 3.719701e-02 | 4 |
| GO:BP | GO:0016444 | somatic cell DNA recombination | "Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma] | 3 | 3.877179e-02 | 4 |
| GO:BP | GO:0002562 | somatic diversification of immune receptors via germline recombination within a single locus | "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] | 3 | 3.877179e-02 | 4 |
| GO:BP | GO:0006282 | regulation of DNA repair | "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] | 4 | 4.005540e-02 | 4 |
| GO:BP | GO:0044774 | mitotic DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle] | 3 | 4.038984e-02 | 4 |
| GO:BP | GO:0042538 | hyperosmotic salinity response | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] | 2 | 4.056272e-02 | 4 |
| GO:BP | GO:0042256 | cytosolic ribosome assembly | "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol." [GOC:ma, PMID:30467428] | 2 | 4.056272e-02 | 4 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 15 | 4.114796e-02 | 4 |
| GO:BP | GO:0042325 | regulation of phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] | 6 | 4.653138e-02 | 4 |
| GO:BP | GO:0045911 | positive regulation of DNA recombination | "Any process that activates or increases the frequency, rate or extent of DNA recombination." [GOC:go_curators] | 3 | 4.730596e-02 | 4 |
| GO:BP | GO:0002200 | somatic diversification of immune receptors | "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] | 3 | 4.914873e-02 | 4 |
| GO:BP | GO:0071481 | cellular response to X-ray | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah] | 2 | 4.955308e-02 | 4 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 5 | 4.956061e-02 | 4 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 15 | 3.445493e-12 | 4 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 9 | 6.352702e-10 | 4 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 7 | 3.827713e-09 | 4 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 16 | 6.813267e-09 | 4 |
| GO:CC | GO:0090734 | site of DNA damage | "A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg] | 6 | 5.924802e-08 | 4 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 16 | 4.365220e-07 | 4 |
| GO:CC | GO:0070418 | DNA-dependent protein kinase complex | "A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku." [GOC:mah, PMID:10854421, PMID:12235392] | 3 | 5.453261e-07 | 4 |
| GO:CC | GO:0070533 | BRCA1-C complex | "A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint." [GOC:mah, PMID:15485915, PMID:16391231] | 3 | 1.090135e-06 | 4 |
| GO:CC | GO:0035861 | site of double-strand break | "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] | 5 | 1.318994e-06 | 4 |
| GO:CC | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex | "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV." [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889] | 3 | 1.906832e-06 | 4 |
| GO:CC | GO:0070419 | nonhomologous end joining complex | "A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends." [GOC:mah, PMID:17072889, PMID:17938628] | 3 | 4.572058e-06 | 4 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 16 | 7.984956e-06 | 4 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 16 | 8.003682e-06 | 4 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 16 | 8.485367e-06 | 4 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 16 | 8.485367e-06 | 4 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 16 | 8.485367e-06 | 4 |
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 4 | 4.056434e-05 | 4 |
| GO:CC | GO:1990391 | DNA repair complex | "A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350] | 3 | 9.575631e-05 | 4 |
| GO:CC | GO:0032993 | protein-DNA complex | "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] | 5 | 1.207183e-04 | 4 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 17 | 2.215945e-04 | 4 |
| GO:CC | GO:0043564 | Ku70:Ku80 complex | "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983] | 2 | 2.416668e-04 | 4 |
| GO:CC | GO:0030870 | Mre11 complex | "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145] | 2 | 1.206698e-03 | 4 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 15 | 1.847973e-03 | 4 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 4 | 3.833497e-03 | 4 |
| GO:CC | GO:0000782 | telomere cap complex | "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh] | 2 | 6.255026e-03 | 4 |
| GO:CC | GO:0000783 | nuclear telomere cap complex | "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh] | 2 | 6.255026e-03 | 4 |
| GO:CC | GO:0140445 | chromosome, telomeric repeat region | "A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop." [PMID:11352055, PMID:30208292] | 2 | 7.294236e-03 | 4 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 9 | 7.726423e-03 | 4 |
| GO:CC | GO:0016363 | nuclear matrix | "A dynamic, proteinaceous framework within the nucleus of eukaryotic cells, composed of proteins and RNA, that provides structural support for chromatin organization, gene regulation, and nuclear processes." [PMID:15608168, PMID:3058729, PMID:39789220] | 3 | 1.797060e-02 | 4 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 3 | 2.241367e-02 | 4 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 7 | 2.929488e-02 | 4 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 3 | 2.975263e-02 | 4 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-73894 | DNA Repair | DNA Repair | 11 | 1.795847e-11 | 4 |
| REAC | REAC:R-HSA-5693532 | DNA Double-Strand Break Repair | DNA Double-Strand Break Repair | 9 | 1.372515e-10 | 4 |
| REAC | REAC:R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | Nonhomologous End-Joining (NHEJ) | 6 | 1.101005e-07 | 4 |
| REAC | REAC:R-HSA-5633007 | Regulation of TP53 Activity | Regulation of TP53 Activity | 6 | 1.983324e-05 | 4 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 7 | 1.069277e-04 | 4 |
| REAC | REAC:R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | HDR through MMEJ (alt-NHEJ) | 3 | 1.787360e-04 | 4 |
| REAC | REAC:R-HSA-9675135 | Diseases of DNA repair | Diseases of DNA repair | 4 | 2.140930e-04 | 4 |
| REAC | REAC:R-HSA-3270619 | IRF3-mediated induction of type I IFN | IRF3-mediated induction of type I IFN | 3 | 2.321508e-04 | 4 |
| REAC | REAC:R-HSA-5693538 | Homology Directed Repair | Homology Directed Repair | 5 | 3.931834e-04 | 4 |
| REAC | REAC:R-HSA-1834941 | STING mediated induction of host immune responses | STING mediated induction of host immune responses | 3 | 4.533533e-04 | 4 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 8 | 5.412583e-04 | 4 |
| REAC | REAC:R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | Cytosolic sensors of pathogen-associated DNA | 4 | 5.834716e-04 | 4 |
| REAC | REAC:R-HSA-5685942 | HDR through Homologous Recombination (HRR) | HDR through Homologous Recombination (HRR) | 4 | 8.375830e-04 | 4 |
| REAC | REAC:R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | 4 | 1.228663e-03 | 4 |
| REAC | REAC:R-HSA-5693606 | DNA Double Strand Break Response | DNA Double Strand Break Response | 4 | 1.293944e-03 | 4 |
| REAC | REAC:R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | Impaired BRCA2 binding to PALB2 | 3 | 1.626964e-03 | 4 |
| REAC | REAC:R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3 | 1.847184e-03 | 4 |
| REAC | REAC:R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | 3 | 1.847184e-03 | 4 |
| REAC | REAC:R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | 3 | 1.847184e-03 | 4 |
| REAC | REAC:R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3 | 1.847184e-03 | 4 |
| REAC | REAC:R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 3 | 2.344973e-03 | 4 |
| REAC | REAC:R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Regulation of TP53 Activity through Phosphorylation | 4 | 2.503755e-03 | 4 |
| REAC | REAC:R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | Impaired BRCA2 binding to RAD51 | 3 | 5.210025e-03 | 4 |
| REAC | REAC:R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | Resolution of D-loop Structures through Holliday Junction Intermediates | 3 | 5.678624e-03 | 4 |
| REAC | REAC:R-HSA-5693537 | Resolution of D-Loop Structures | Resolution of D-Loop Structures | 3 | 6.174200e-03 | 4 |
| REAC | REAC:R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | HDR through Single Strand Annealing (SSA) | 3 | 6.174200e-03 | 4 |
| REAC | REAC:R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | Presynaptic phase of homologous DNA pairing and strand exchange | 3 | 7.829984e-03 | 4 |
| REAC | REAC:R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | Diseases of DNA Double-Strand Break Repair | 3 | 8.440649e-03 | 4 |
| REAC | REAC:R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3 | 8.440649e-03 | 4 |
| REAC | REAC:R-HSA-5693548 | Sensing of DNA Double Strand Breaks | Sensing of DNA Double Strand Breaks | 2 | 9.620903e-03 | 4 |
| REAC | REAC:R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | Homologous DNA Pairing and Strand Exchange | 3 | 9.754352e-03 | 4 |
| REAC | REAC:R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4 | 1.109018e-02 | 4 |
| REAC | REAC:R-HSA-164843 | 2-LTR circle formation | 2-LTR circle formation | 2 | 1.345784e-02 | 4 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 10 | 1.656781e-02 | 4 |
| REAC | REAC:R-HSA-162592 | Integration of provirus | Integration of provirus | 2 | 2.303146e-02 | 4 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 9 | 2.626957e-02 | 4 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 8 | 4.462308e-02 | 4 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4016 | DNA IR damage and cellular response via ATR | DNA IR damage and cellular response via ATR | 8 | 6.176180e-11 | 4 |
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 8 | 1.459676e-09 | 4 |
| WP | WP:WP3959 | DNA IR double strand breaks and cellular response via ATM | DNA IR double strand breaks and cellular response via ATM | 5 | 4.546089e-06 | 4 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 5 | 1.447180e-05 | 4 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 5 | 1.926033e-05 | 4 |
| WP | WP:WP438 | Non homologous end joining | Non homologous end joining | 3 | 8.045511e-05 | 4 |
| WP | WP:WP5118 | SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome | SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome | 3 | 1.105025e-04 | 4 |
| WP | WP:WP3878 | ATM signaling in development and disease | ATM signaling in development and disease | 4 | 1.708170e-04 | 4 |
| WP | WP:WP5527 | NF kB signaling and ARTD family members | NF kB signaling and ARTD family members | 3 | 2.152769e-03 | 4 |
| WP | WP:WP2516 | ATM signaling | ATM signaling | 3 | 5.054919e-03 | 4 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 4 | 5.733683e-03 | 4 |
| WP | WP:WP314 | Fas ligand pathway and stress induction of heat shock proteins | Fas ligand pathway and stress induction of heat shock proteins | 3 | 7.426982e-03 | 4 |
| WP | WP:WP1971 | Integrated cancer pathway | Integrated cancer pathway | 3 | 8.549103e-03 | 4 |
| WP | WP:WP2942 | DDX1 as a regulatory component of the Drosha microprocessor | DDX1 as a regulatory component of the Drosha microprocessor | 2 | 8.821540e-03 | 4 |
| WP | WP:WP4673 | Male infertility | Male infertility | 4 | 1.518535e-02 | 4 |
| WP | WP:WP1984 | Integrated breast cancer pathway | Integrated breast cancer pathway | 4 | 1.823085e-02 | 4 |
| WP | WP:WP3651 | Pathways affected in adenoid cystic carcinoma | Pathways affected in adenoid cystic carcinoma | 3 | 2.754269e-02 | 4 |
| WP | WP:WP5316 | Primary ovarian insufficiency | Primary ovarian insufficiency | 4 | 3.003572e-02 | 4 |
| WP | WP:WP186 | Homologous recombination | Homologous recombination | 2 | 3.255665e-02 | 4 |
| WP | WP:WP5114 | Nucleotide excision repair in xeroderma pigmentosum | Nucleotide excision repair in xeroderma pigmentosum | 3 | 4.046659e-02 | 4 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 11 | 3.672397e-09 | 4 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 11 | 3.885993e-09 | 4 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 11 | 1.690799e-08 | 4 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 11 | 3.041803e-08 | 4 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 10 | 3.637242e-08 | 4 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 11 | 3.766972e-08 | 4 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 11 | 3.941346e-08 | 4 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 11 | 1.119736e-07 | 4 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 11 | 1.334337e-07 | 4 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 12 | 1.585405e-07 | 4 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 10 | 1.665760e-07 | 4 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 11 | 3.228527e-07 | 4 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 10 | 3.460393e-07 | 4 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 11 | 3.828046e-07 | 4 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 11 | 3.921431e-07 | 4 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 16 | 6.247800e-07 | 4 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 10 | 6.720280e-07 | 4 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 11 | 9.312663e-07 | 4 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 10 | 1.121707e-06 | 4 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 10 | 1.183616e-06 | 4 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 7 | 1.605353e-06 | 4 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 11 | 1.752075e-06 | 4 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 10 | 1.776510e-06 | 4 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 10 | 1.893643e-06 | 4 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 9 | 2.558783e-06 | 4 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 8 | 3.783154e-06 | 4 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 10 | 4.587791e-06 | 4 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 8 | 4.873871e-06 | 4 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 10 | 5.029707e-06 | 4 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 10 | 7.859474e-06 | 4 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 12 | 8.179468e-06 | 4 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 9 | 8.454514e-06 | 4 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 10 | 8.479257e-06 | 4 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 9 | 9.291983e-06 | 4 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 9 | 2.102506e-05 | 4 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 6 | 4.230491e-05 | 4 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 9 | 5.736384e-05 | 4 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 8 | 5.918031e-05 | 4 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 15 | 6.083706e-05 | 4 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 8 | 8.813822e-05 | 4 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 6 | 1.011342e-04 | 4 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 6 | 1.061849e-04 | 4 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 6 | 1.225964e-04 | 4 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 8 | 1.523120e-04 | 4 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 12 | 1.710024e-04 | 4 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 10 | 1.921320e-04 | 4 |
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 8 | 2.065511e-04 | 4 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 12 | 2.393377e-04 | 4 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 7 | 2.449411e-04 | 4 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 7 | 2.874919e-04 | 4 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 15 | 3.769572e-04 | 4 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 6 | 5.036966e-04 | 4 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 15 | 5.268230e-04 | 4 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 6 | 5.417820e-04 | 4 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 15 | 5.695620e-04 | 4 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 16 | 5.760989e-04 | 4 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 13 | 6.612786e-04 | 4 |
| HPA | HPA:0500701 | Soft tissue 1; peripheral nerve[≥Low] | Soft tissue 1; peripheral nerve[≥Low] | 13 | 6.699418e-04 | 4 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 10 | 9.000643e-04 | 4 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 15 | 9.847165e-04 | 4 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 6 | 1.002877e-03 | 4 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 12 | 2.674388e-03 | 4 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 15 | 2.774722e-03 | 4 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 8 | 4.028496e-03 | 4 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 5 | 4.181832e-03 | 4 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 12 | 4.259450e-03 | 4 |
| HPA | HPA:0471493 | Skin 2; vascular mural cells[High] | Skin 2; vascular mural cells[High] | 4 | 4.404279e-03 | 4 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 14 | 4.470799e-03 | 4 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 14 | 4.470799e-03 | 4 |
| HPA | HPA:0461493 | Skin 1; vascular mural cells[High] | Skin 1; vascular mural cells[High] | 4 | 5.265950e-03 | 4 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 12 | 6.263193e-03 | 4 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 10 | 6.270182e-03 | 4 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 7 | 6.335958e-03 | 4 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 5 | 6.651019e-03 | 4 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 16 | 6.690234e-03 | 4 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 16 | 6.690234e-03 | 4 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 5 | 6.983230e-03 | 4 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 15 | 7.898184e-03 | 4 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 11 | 7.994653e-03 | 4 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 14 | 8.614384e-03 | 4 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 16 | 8.693675e-03 | 4 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 9 | 9.434419e-03 | 4 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 15 | 9.473504e-03 | 4 |
| HPA | HPA:0471452 | Skin 2; hair follicles[≥Medium] | Skin 2; hair follicles[≥Medium] | 4 | 1.023638e-02 | 4 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 16 | 1.055860e-02 | 4 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 6 | 1.221223e-02 | 4 |
| HPA | HPA:0510702 | Soft tissue 2; peripheral nerve[≥Medium] | Soft tissue 2; peripheral nerve[≥Medium] | 9 | 1.385972e-02 | 4 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 15 | 1.567111e-02 | 4 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 14 | 1.569027e-02 | 4 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 16 | 1.603577e-02 | 4 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 14 | 1.645077e-02 | 4 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 16 | 1.741103e-02 | 4 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 16 | 1.741103e-02 | 4 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 8 | 1.761201e-02 | 4 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 12 | 1.781380e-02 | 4 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 15 | 1.877602e-02 | 4 |
| HPA | HPA:0461492 | Skin 1; vascular mural cells[≥Medium] | Skin 1; vascular mural cells[≥Medium] | 4 | 1.954201e-02 | 4 |
| HPA | HPA:0461393 | Skin 1; cells in basal layer[High] | Skin 1; cells in basal layer[High] | 4 | 2.035341e-02 | 4 |
| HPA | HPA:0471492 | Skin 2; vascular mural cells[≥Medium] | Skin 2; vascular mural cells[≥Medium] | 4 | 2.076818e-02 | 4 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 14 | 2.182625e-02 | 4 |
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 5 | 2.228548e-02 | 4 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 15 | 2.262115e-02 | 4 |
| HPA | HPA:0471451 | Skin 2; hair follicles[≥Low] | Skin 2; hair follicles[≥Low] | 4 | 2.293484e-02 | 4 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 15 | 2.490390e-02 | 4 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 6 | 3.014614e-02 | 4 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 16 | 3.193050e-02 | 4 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 16 | 3.193050e-02 | 4 |
| HPA | HPA:0340000 | Ovary | Ovary | 15 | 3.198620e-02 | 4 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 15 | 3.317429e-02 | 4 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 15 | 3.317429e-02 | 4 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 16 | 3.446445e-02 | 4 |
| HPA | HPA:0500702 | Soft tissue 1; peripheral nerve[≥Medium] | Soft tissue 1; peripheral nerve[≥Medium] | 8 | 3.925306e-02 | 4 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 16 | 4.220832e-02 | 4 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 15 | 4.859633e-02 | 4 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 16 | 4.890900e-02 | 4 |
| HPA | HPA:0390000 | Prostate | Prostate | 16 | 4.890900e-02 | 4 |
| HPA | HPA:0130652 | Colon; fibroblasts[≥Medium] | Colon; fibroblasts[≥Medium] | 3 | 4.964846e-02 | 4 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003684 | damaged DNA binding | "Binding to damaged DNA." [GOC:jl] | 6 | 7.404637e-09 | 4 |
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 6 | 1.478904e-07 | 4 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 13 | 7.370041e-07 | 4 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 7 | 5.955141e-06 | 4 |
| GO:MF | GO:0003691 | double-stranded telomeric DNA binding | "Binding to double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] | 3 | 1.112839e-05 | 4 |
| GO:MF | GO:0140097 | catalytic activity, acting on DNA | "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] | 6 | 1.257922e-05 | 4 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 9 | 8.117980e-05 | 4 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 7 | 1.048472e-04 | 4 |
| GO:MF | GO:0045027 | DNA end binding | "Binding to DNA ends exposed by the creation of double-strand breaks (DSBs)." [GOC:jl] | 2 | 5.377951e-04 | 4 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 9 | 5.608198e-04 | 4 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 14 | 7.702411e-04 | 4 |
| GO:MF | GO:0042162 | telomeric DNA binding | "Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624] | 3 | 1.100917e-03 | 4 |
| GO:MF | GO:0004386 | helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] | 4 | 2.175599e-03 | 4 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 6 | 2.335069e-03 | 4 |
| GO:MF | GO:0140640 | catalytic activity, acting on a nucleic acid | "Catalytic activity that acts to modify a nucleic acid." [GOC:pg] | 6 | 2.530457e-03 | 4 |
| GO:MF | GO:0120545 | nucleic acid conformation isomerase activity | "Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-] | 4 | 2.768739e-03 | 4 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 8 | 3.452490e-03 | 4 |
| GO:MF | GO:0003678 | DNA helicase activity | "Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl] | 3 | 4.196515e-03 | 4 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 8 | 4.223053e-03 | 4 |
| GO:MF | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity | "Catalysis of the reaction: a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H+." [PMID:11251121, PMID:16120966, PMID:9614142, RHEA:76255] | 2 | 5.007037e-03 | 4 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 9 | 7.023550e-03 | 4 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 7 | 7.882423e-03 | 4 |
| GO:MF | GO:0034511 | U3 snoRNA binding | "Binding to a U3 small nucleolar RNA." [GOC:mah] | 2 | 8.039077e-03 | 4 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 5 | 1.048767e-02 | 4 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 7 | 1.080024e-02 | 4 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 7 | 1.085556e-02 | 4 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 7 | 1.085556e-02 | 4 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 9 | 1.249008e-02 | 4 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 9 | 1.326363e-02 | 4 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 14 | 1.420737e-02 | 4 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 9 | 2.043039e-02 | 4 |
| GO:MF | GO:0031491 | nucleosome binding | "Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah] | 3 | 2.043401e-02 | 4 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 4 | 2.289328e-02 | 4 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 5 | 2.774546e-02 | 4 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 8 | 3.511742e-02 | 4 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 3 | 3.688580e-02 | 4 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 8 | 4.294805e-02 | 4 |
| GO:MF | GO:1990404 | NAD+-protein mono-ADP-ribosyltransferase activity | "Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide." [PMID:1899243] | 2 | 4.490819e-02 | 4 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 8 | 4.541569e-02 | 4 |
| GO:MF | GO:0003950 | NAD+ poly-ADP-ribosyltransferase activity | "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] | 2 | 4.896657e-02 | 4 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03450 | Non-homologous end-joining | Non-homologous end-joining | 4 | 1.897216e-07 | 4 |
| KEGG | KEGG:03440 | Homologous recombination | Homologous recombination | 3 | 2.119543e-03 | 4 |
| KEGG | KEGG:03430 | Mismatch repair | Mismatch repair | 2 | 3.617340e-02 | 4 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:433 | BASC complex (BRCA1-associated genome surveillance complex) | BASC complex (BRCA1-associated genome surveillance complex) | 4 | 0.000047 | 4 |
| CORUM | CORUM:2815 | BRCA1-BARD1-BACH1-DNA damage complex II | BRCA1-BARD1-BACH1-DNA damage complex II | 3 | 0.001644 | 4 |
| CORUM | CORUM:173 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 0.025057 | 4 |
| CORUM | CORUM:331 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 0.025057 | 4 |
| CORUM | CORUM:972 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 0.025057 | 4 |
| CORUM | CORUM:71 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 0.025057 | 4 |
| CORUM | CORUM:5179 | NCOA6-DNA-PK-Ku-PARP1 complex | NCOA6-DNA-PK-Ku-PARP1 complex | 2 | 0.025057 | 4 |
| CORUM | CORUM:73 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 0.025057 | 4 |
| CORUM | CORUM:618 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 0.025057 | 4 |
| CORUM | CORUM:2767 | RAD50-MRE11-NBN-p200-p350 complex | RAD50-MRE11-NBN-p200-p350 complex | 2 | 0.025057 | 4 |
| CORUM | CORUM:1081 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 0.025057 | 4 |
| CORUM | CORUM:627 | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) | 2 | 0.049996 | 4 |
| CORUM | CORUM:964 | BRCA1-RAD50-MRE11-NBS1 complex | BRCA1-RAD50-MRE11-NBS1 complex | 2 | 0.049996 | 4 |
| CORUM | CORUM:202 | BRCA1-RAD50-MRE11-NBS1 complex | BRCA1-RAD50-MRE11-NBS1 complex | 2 | 0.049996 | 4 |
| CORUM | CORUM:619 | MRE11A-RAD50-NBN-TRF2 complex | MRE11A-RAD50-NBN-TRF2 complex | 2 | 0.049996 | 4 |
| CORUM | CORUM:2218 | MDC1-MRE11-RAD50-NBS1 complex | MDC1-MRE11-RAD50-NBS1 complex | 2 | 0.049996 | 4 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0010785 | Gonadal neoplasm | A tumor (abnormal growth of tissue) of a gonad. | 6 | 0.000068 | 4 |
| HP | HP:0100615 | Ovarian neoplasm | A tumor (abnormal growth of tissue) of the ovary. | 5 | 0.000566 | 4 |
| HP | HP:0010787 | Genital neoplasm | A tumor (abnormal growth of tissue) of the genital system. | 6 | 0.000728 | 4 |
| HP | HP:0100013 | Neoplasm of the breast | A tumor (abnormal growth of tissue) of the breast. | 5 | 0.002093 | 4 |
| HP | HP:0030406 | Primary peritoneal carcinoma | A type of cancer that originates in the peritoneum. It is to be distinguished from metastatic cancer of the peritoneum. Peritoneal cancer can occur anywhere in the abdominal space, and affects the surface of organs contained inside the peritoneum. | 3 | 0.004884 | 4 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 6 | 0.008432 | 4 |
| HP | HP:0003002 | Breast carcinoma | The presence of a carcinoma of the breast. | 4 | 0.021543 | 4 |
| HP | HP:0007378 | Neoplasm of the gastrointestinal tract | A tumor (abnormal growth of tissue) of the gastrointestinal tract. | 6 | 0.035838 | 4 |
| HP | HP:0011027 | Abnormal fallopian tube morphology | An abnormality of the fallopian tube. | 3 | 0.038571 | 4 |
| HP | HP:0000008 | Abnormal morphology of female internal genitalia | An abnormality of the female internal genitalia. | 7 | 0.041060 | 4 |
| HP | HP:0002894 | Neoplasm of the pancreas | A tumor (abnormal growth of tissue) of the pancreas. | 4 | 0.048357 | 4 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00739 | Factor: E2F-4:DP-2; motif: TTTCSCGC | Factor: E2F-4:DP-2; motif: TTTCSCGC | 15 | 0.000932 | 4 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 14 | 0.001075 | 4 |
| TF | TF:M00737_1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | 11 | 0.008115 | 4 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 7 | 0.010812 | 4 |
| MIRNA | MIRNA:hsa-mir-134 | hsa-mir-134 | hsa-mir-134 | 6 | 0.049532 | 4 |
Community 5
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051086 | chaperone mediated protein folding independent of cofactor | "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] | 8 | 3.162859e-22 | 5 |
| GO:BP | GO:1904874 | positive regulation of telomerase RNA localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 2.845008e-21 | 5 |
| GO:BP | GO:1904869 | regulation of protein localization to Cajal body | "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.421722e-20 | 5 |
| GO:BP | GO:1904871 | positive regulation of protein localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.421722e-20 | 5 |
| GO:BP | GO:1903405 | protein localization to nuclear body | "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849] | 8 | 1.562175e-19 | 5 |
| GO:BP | GO:1904867 | protein localization to Cajal body | "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.562175e-19 | 5 |
| GO:BP | GO:1904872 | regulation of telomerase RNA localization to Cajal body | "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.562175e-19 | 5 |
| GO:BP | GO:1990173 | protein localization to nucleoplasm | "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952] | 8 | 9.466774e-19 | 5 |
| GO:BP | GO:0090685 | RNA localization to nucleus | "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] | 8 | 2.376132e-17 | 5 |
| GO:BP | GO:0090672 | telomerase RNA localization | "Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 8 | 2.376132e-17 | 5 |
| GO:BP | GO:0090671 | telomerase RNA localization to Cajal body | "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 8 | 2.376132e-17 | 5 |
| GO:BP | GO:0090670 | RNA localization to Cajal body | "A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 8 | 2.376132e-17 | 5 |
| GO:BP | GO:0032212 | positive regulation of telomere maintenance via telomerase | "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 8 | 2.305807e-16 | 5 |
| GO:BP | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 8 | 6.948772e-16 | 5 |
| GO:BP | GO:0051084 | 'de novo' post-translational protein folding | "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] | 8 | 4.498926e-14 | 5 |
| GO:BP | GO:0032210 | regulation of telomere maintenance via telomerase | "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 8 | 8.082145e-14 | 5 |
| GO:BP | GO:0006458 | 'de novo' protein folding | "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] | 8 | 1.167516e-13 | 5 |
| GO:BP | GO:2000573 | positive regulation of DNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 8 | 1.966889e-13 | 5 |
| GO:BP | GO:1904356 | regulation of telomere maintenance via telomere lengthening | "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 8 | 3.752648e-13 | 5 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 8 | 7.864204e-13 | 5 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 8 | 1.188411e-12 | 5 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 8 | 4.102092e-12 | 5 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 8 | 4.596781e-12 | 5 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 8 | 5.142815e-12 | 5 |
| GO:BP | GO:0007339 | binding of sperm to zona pellucida | "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] | 7 | 8.684268e-12 | 5 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 8 | 2.810917e-11 | 5 |
| GO:BP | GO:1900182 | positive regulation of protein localization to nucleus | "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 8 | 3.664604e-11 | 5 |
| GO:BP | GO:0035036 | sperm-egg recognition | "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf] | 7 | 7.125786e-11 | 5 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 8 | 8.359776e-11 | 5 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 8 | 1.420159e-10 | 5 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 9 | 5.821211e-10 | 5 |
| GO:BP | GO:0009988 | cell-cell recognition | "Cell recognition between cells. May involve the formation of specialized cell junctions." [ISBN:0824072820] | 7 | 9.058402e-10 | 5 |
| GO:BP | GO:0033044 | regulation of chromosome organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] | 9 | 1.170546e-09 | 5 |
| GO:BP | GO:1900180 | regulation of protein localization to nucleus | "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 8 | 1.234776e-09 | 5 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 8 | 3.166961e-09 | 5 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 8 | 4.653212e-09 | 5 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 8 | 1.082578e-08 | 5 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 9 | 1.363073e-08 | 5 |
| GO:BP | GO:0006403 | RNA localization | "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] | 8 | 1.567504e-08 | 5 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 10 | 1.850806e-08 | 5 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 9 | 2.171583e-08 | 5 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 8 | 3.246052e-08 | 5 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 10 | 8.419099e-08 | 5 |
| GO:BP | GO:0008037 | cell recognition | "The process in which a cell in an organism interprets its surroundings." [GOC:go_curators] | 7 | 1.937205e-07 | 5 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 8 | 3.130521e-07 | 5 |
| GO:BP | GO:0007338 | single fertilization | "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] | 7 | 3.651745e-07 | 5 |
| GO:BP | GO:1903829 | positive regulation of protein localization | "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 9 | 7.458527e-07 | 5 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 9 | 1.469918e-06 | 5 |
| GO:BP | GO:0009566 | fertilization | "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] | 7 | 1.712161e-06 | 5 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 11 | 2.564382e-06 | 5 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 11 | 3.833882e-06 | 5 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 15 | 5.287106e-06 | 5 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 14 | 5.767428e-06 | 5 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 10 | 7.144321e-06 | 5 |
| GO:BP | GO:0022414 | reproductive process | "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] | 12 | 8.668985e-06 | 5 |
| GO:BP | GO:0090666 | scaRNA localization to Cajal body | "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 3 | 1.261038e-05 | 5 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 10 | 2.058216e-05 | 5 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 8 | 2.204570e-05 | 5 |
| GO:BP | GO:0019953 | sexual reproduction | "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] | 10 | 5.441297e-05 | 5 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 15 | 8.537054e-05 | 5 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 10 | 1.102703e-04 | 5 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 12 | 1.236382e-04 | 5 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 14 | 2.915281e-04 | 5 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 16 | 3.758162e-04 | 5 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 14 | 9.181186e-04 | 5 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 12 | 2.712123e-03 | 5 |
| GO:BP | GO:1904851 | positive regulation of establishment of protein localization to telomere | "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 2 | 4.188970e-03 | 5 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 8 | 4.542725e-03 | 5 |
| GO:BP | GO:0009185 | ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 9.998746e-03 | 5 |
| GO:BP | GO:0009132 | nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 1.238819e-02 | 5 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 10 | 1.308192e-02 | 5 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 11 | 1.554510e-02 | 5 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 18 | 2.055847e-02 | 5 |
| GO:BP | GO:0070203 | regulation of establishment of protein localization to telomere | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah] | 2 | 2.090702e-02 | 5 |
| GO:BP | GO:1904816 | positive regulation of protein localization to chromosome, telomeric region | "Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455] | 2 | 2.090702e-02 | 5 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 13 | 2.614053e-02 | 5 |
| GO:BP | GO:0070202 | regulation of establishment of protein localization to chromosome | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] | 2 | 2.925219e-02 | 5 |
| GO:BP | GO:0033121 | regulation of purine nucleotide catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] | 3 | 3.030971e-02 | 5 |
| GO:BP | GO:0030811 | regulation of nucleotide catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] | 3 | 3.030971e-02 | 5 |
| GO:BP | GO:0006110 | regulation of glycolytic process | "Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators] | 3 | 3.030971e-02 | 5 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 18 | 3.096297e-02 | 5 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005832 | chaperonin-containing T-complex | "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] | 8 | 1.122511e-21 | 5 |
| GO:CC | GO:0101031 | protein folding chaperone complex | "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] | 8 | 2.345137e-15 | 5 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 12 | 5.455104e-13 | 5 |
| GO:CC | GO:0002199 | zona pellucida receptor complex | "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732] | 5 | 4.510293e-12 | 5 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 13 | 1.772352e-10 | 5 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 13 | 1.948510e-10 | 5 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 12 | 2.399727e-10 | 5 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 14 | 2.902066e-10 | 5 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 14 | 3.250129e-10 | 5 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 12 | 1.247579e-09 | 5 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 14 | 5.259813e-08 | 5 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 14 | 6.350709e-08 | 5 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 14 | 6.390423e-08 | 5 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 14 | 6.390423e-08 | 5 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 19 | 7.572510e-08 | 5 |
| GO:CC | GO:0044297 | cell body | "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] | 9 | 1.771029e-07 | 5 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 14 | 4.336809e-07 | 5 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 16 | 2.003829e-06 | 5 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 14 | 1.987041e-05 | 5 |
| GO:CC | GO:0035578 | azurophil granule lumen | "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] | 4 | 2.662873e-04 | 5 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 17 | 3.765061e-04 | 5 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 17 | 3.773787e-04 | 5 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 14 | 4.787251e-04 | 5 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 21 | 1.108762e-03 | 5 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 5 | 1.890877e-03 | 5 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 5 | 2.036621e-03 | 5 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 5 | 2.066796e-03 | 5 |
| GO:CC | GO:0042582 | azurophil granule | "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule] | 4 | 2.215555e-03 | 5 |
| GO:CC | GO:0005766 | primary lysosome | "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] | 4 | 2.215555e-03 | 5 |
| GO:CC | GO:0005775 | vacuolar lumen | "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] | 4 | 3.989619e-03 | 5 |
| GO:CC | GO:0005819 | spindle | "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] | 5 | 8.151965e-03 | 5 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 6 | 8.860851e-03 | 5 |
| GO:CC | GO:0005764 | lysosome | "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] | 6 | 1.057020e-02 | 5 |
| GO:CC | GO:0000323 | lytic vacuole | "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] | 6 | 1.057020e-02 | 5 |
| GO:CC | GO:0005773 | vacuole | "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] | 6 | 2.037978e-02 | 5 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 6 | 2.295851e-02 | 5 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 6 | 2.610548e-02 | 5 |
| GO:CC | GO:0000242 | pericentriolar material | "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] | 2 | 3.442365e-02 | 5 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 16 | 3.507028e-02 | 5 |
| GO:CC | GO:0005881 | cytoplasmic microtubule | "Any microtubule in the cytoplasm of a cell." [GOC:mah] | 3 | 3.550762e-02 | 5 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | Formation of tubulin folding intermediates by CCT/TriC | 10 | 8.336940e-20 | 5 |
| REAC | REAC:R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | Prefoldin mediated transfer of substrate to CCT/TriC | 10 | 2.055965e-19 | 5 |
| REAC | REAC:R-HSA-390450 | Folding of actin by CCT/TriC | Folding of actin by CCT/TriC | 8 | 5.542450e-19 | 5 |
| REAC | REAC:R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 10 | 1.443537e-18 | 5 |
| REAC | REAC:R-HSA-390466 | Chaperonin-mediated protein folding | Chaperonin-mediated protein folding | 10 | 9.505814e-14 | 5 |
| REAC | REAC:R-HSA-391251 | Protein folding | Protein folding | 10 | 1.849951e-13 | 5 |
| REAC | REAC:R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | Association of TriC/CCT with target proteins during biosynthesis | 8 | 5.848301e-13 | 5 |
| REAC | REAC:R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 8 | 5.848301e-13 | 5 |
| REAC | REAC:R-HSA-5617833 | Cilium Assembly | Cilium Assembly | 10 | 3.004008e-10 | 5 |
| REAC | REAC:R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | BBSome-mediated cargo-targeting to cilium | 6 | 7.034362e-10 | 5 |
| REAC | REAC:R-HSA-1852241 | Organelle biogenesis and maintenance | Organelle biogenesis and maintenance | 10 | 1.262164e-08 | 5 |
| REAC | REAC:R-HSA-5620920 | Cargo trafficking to the periciliary membrane | Cargo trafficking to the periciliary membrane | 6 | 1.214462e-07 | 5 |
| REAC | REAC:R-HSA-68877 | Mitotic Prometaphase | Mitotic Prometaphase | 6 | 4.663023e-04 | 5 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 14 | 6.353221e-04 | 5 |
| REAC | REAC:R-HSA-9013418 | RHOBTB2 GTPase cycle | RHOBTB2 GTPase cycle | 3 | 3.339349e-03 | 5 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 4 | 8.625243e-03 | 5 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 5 | 8.866478e-03 | 5 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 5 | 9.310263e-03 | 5 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 8 | 9.480961e-03 | 5 |
| REAC | REAC:R-HSA-9706574 | RHOBTB GTPase Cycle | RHOBTB GTPase Cycle | 3 | 1.216061e-02 | 5 |
| REAC | REAC:R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | EML4 and NUDC in mitotic spindle formation | 4 | 1.905117e-02 | 5 |
| REAC | REAC:R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | Resolution of Sister Chromatid Cohesion | 4 | 2.556503e-02 | 5 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 6 | 2.691447e-02 | 5 |
| REAC | REAC:R-HSA-1632852 | Macroautophagy | Macroautophagy | 4 | 3.456113e-02 | 5 |
| REAC | REAC:R-HSA-5663220 | RHO GTPases Activate Formins | RHO GTPases Activate Formins | 4 | 3.660476e-02 | 5 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:126 | CCT complex (chaperonin containing TCP1 complex) | CCT complex (chaperonin containing TCP1 complex) | 8 | 1.210263e-17 | 5 |
| CORUM | CORUM:6247 | BBS-chaperonin complex | BBS-chaperonin complex | 6 | 3.186939e-10 | 5 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 8 | 7.262652e-16 | 5 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 9 | 3.383685e-13 | 5 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 8 | 6.662838e-13 | 5 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 15 | 5.259988e-07 | 5 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 8 | 1.394840e-06 | 5 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 14 | 3.988925e-06 | 5 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 13 | 4.210280e-06 | 5 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 13 | 5.946292e-06 | 5 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 13 | 6.544933e-06 | 5 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 13 | 1.000591e-05 | 5 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 13 | 2.361055e-05 | 5 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 13 | 2.582751e-05 | 5 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 10 | 3.219961e-05 | 5 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 8 | 3.650004e-05 | 5 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 13 | 4.443083e-05 | 5 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 10 | 5.090899e-05 | 5 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 10 | 5.128889e-05 | 5 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 10 | 5.128889e-05 | 5 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 18 | 4.121977e-04 | 5 |
| GO:MF | GO:0016787 | hydrolase activity | "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] | 13 | 8.483659e-04 | 5 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 17 | 1.369876e-03 | 5 |
| GO:MF | GO:0005200 | structural constituent of cytoskeleton | "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] | 4 | 1.698538e-03 | 5 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 17 | 2.197190e-03 | 5 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 9 | 2.976390e-03 | 5 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 9 | 3.719050e-03 | 5 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 9 | 5.951590e-03 | 5 |
| GO:MF | GO:0042288 | MHC class I protein binding | "Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] | 2 | 4.974865e-02 | 5 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4949 | 16p11 2 proximal deletion syndrome | 16p11 2 proximal deletion syndrome | 9 | 6.527823e-12 | 5 |
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 5 | 7.594468e-04 | 5 |
| WP | WP:WP2272 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 3 | 4.037851e-02 | 5 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 17 | 0.000581 | 5 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 17 | 0.001436 | 5 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 19 | 0.001487 | 5 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 14 | 0.005081 | 5 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 10 | 0.008150 | 5 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 19 | 0.013341 | 5 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 19 | 0.017046 | 5 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 19 | 0.017383 | 5 |
| HPA | HPA:0530000 | Spleen | Spleen | 18 | 0.019516 | 5 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 19 | 0.022879 | 5 |
| HPA | HPA:0630000 | Cervix | Cervix | 19 | 0.023260 | 5 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 8 | 0.025298 | 5 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 18 | 0.027021 | 5 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 19 | 0.031326 | 5 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 17 | 0.032440 | 5 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 19 | 0.033337 | 5 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 18 | 0.036743 | 5 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 16 | 0.037312 | 5 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 12 | 0.038500 | 5 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 18 | 0.040688 | 5 |
| HPA | HPA:0050000 | Breast | Breast | 19 | 0.046837 | 5 |
| HPA | HPA:0340000 | Ovary | Ovary | 17 | 0.047176 | 5 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 19 | 0.048995 | 5 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04814 | Motor proteins | Motor proteins | 4 | 0.006552 | 5 |
| KEGG | KEGG:04540 | Gap junction | Gap junction | 3 | 0.013043 | 5 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 9 | 0.020835 | 5 |
| MIRNA | MIRNA:hsa-mir-151a-5p | hsa-mir-151a-5p | hsa-mir-151a-5p | 3 | 0.028403 | 5 |
| MIRNA | MIRNA:hsa-mir-301a-3p | hsa-mir-301a-3p | hsa-mir-301a-3p | 5 | 0.043544 | 5 |
Community 6
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 15 | 2.317074e-33 | 6 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 15 | 2.519292e-28 | 6 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 15 | 1.141733e-27 | 6 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 15 | 1.312670e-22 | 6 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 17 | 5.814061e-20 | 6 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 17 | 5.147805e-15 | 6 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 17 | 1.158792e-08 | 6 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 9 | 5.687790e-07 | 6 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 11 | 5.981534e-07 | 6 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 17 | 9.025772e-07 | 6 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 9 | 2.541304e-06 | 6 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 17 | 1.984292e-05 | 6 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 17 | 1.984292e-05 | 6 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 17 | 1.984292e-05 | 6 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 19 | 4.937921e-05 | 6 |
| GO:CC | GO:0070557 | PCNA-p21 complex | "A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication." [GOC:mah, PMID:7911228, PMID:7915843] | 2 | 1.092740e-04 | 6 |
| GO:CC | GO:0097125 | cyclin B1-CDK1 complex | "A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 1.092740e-04 | 6 |
| GO:CC | GO:0097131 | cyclin D1-CDK6 complex | "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 1.092740e-04 | 6 |
| GO:CC | GO:0097122 | cyclin A2-CDK1 complex | "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 1.092740e-04 | 6 |
| GO:CC | GO:0097133 | cyclin D3-CDK6 complex | "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 1.092740e-04 | 6 |
| GO:CC | GO:0097130 | cyclin D3-CDK4 complex | "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 1.092740e-04 | 6 |
| GO:CC | GO:0097128 | cyclin D1-CDK4 complex | "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 1.092740e-04 | 6 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 11 | 1.662836e-04 | 6 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 15 | 1.910053e-04 | 6 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 16 | 2.527865e-04 | 6 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 16 | 2.533494e-04 | 6 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 17 | 3.200638e-04 | 6 |
| GO:CC | GO:0097129 | cyclin D2-CDK4 complex | "A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 3.276542e-04 | 6 |
| GO:CC | GO:0032806 | carboxy-terminal domain protein kinase complex | "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683] | 2 | 2.057169e-02 | 6 |
| GO:CC | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] | 2 | 3.508058e-02 | 6 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 15 | 6.710262e-32 | 6 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 15 | 6.710262e-32 | 6 |
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 10 | 5.373678e-20 | 6 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 15 | 3.273583e-18 | 6 |
| GO:MF | GO:0016772 | transferase activity, transferring phosphorus-containing groups | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] | 17 | 3.843395e-17 | 6 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 16 | 2.706816e-16 | 6 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 15 | 5.804148e-16 | 6 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 15 | 4.864679e-15 | 6 |
| GO:MF | GO:0016740 | transferase activity | "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-] | 18 | 3.947308e-13 | 6 |
| GO:MF | GO:0019887 | protein kinase regulator activity | "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] | 10 | 1.097890e-12 | 6 |
| GO:MF | GO:0019207 | kinase regulator activity | "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] | 10 | 4.825722e-12 | 6 |
| GO:MF | GO:0030332 | cyclin binding | "Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] | 6 | 1.080223e-10 | 6 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 16 | 4.155249e-09 | 6 |
| GO:MF | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity | "Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810] | 4 | 1.583602e-07 | 6 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 10 | 1.605763e-07 | 6 |
| GO:MF | GO:0030295 | protein kinase activator activity | "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] | 6 | 5.455686e-07 | 6 |
| GO:MF | GO:0019209 | kinase activator activity | "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] | 6 | 7.741824e-07 | 6 |
| GO:MF | GO:0030234 | enzyme regulator activity | "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 11 | 1.348154e-06 | 6 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 9 | 1.609633e-06 | 6 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 18 | 1.134453e-05 | 6 |
| GO:MF | GO:0098772 | molecular function regulator activity | "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt] | 12 | 1.786266e-05 | 6 |
| GO:MF | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr] | 3 | 4.406029e-05 | 6 |
| GO:MF | GO:0043539 | protein serine/threonine kinase activator activity | "Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators] | 4 | 1.323745e-04 | 6 |
| GO:MF | GO:0106310 | protein serine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989] | 6 | 1.943919e-04 | 6 |
| GO:MF | GO:0008047 | enzyme activator activity | "Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 7 | 2.300172e-04 | 6 |
| GO:MF | GO:0019912 | cyclin-dependent protein kinase activating kinase activity | "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)." [GOC:go_curators] | 2 | 2.397672e-04 | 6 |
| GO:MF | GO:0140677 | molecular function activator activity | "A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators] | 8 | 1.554600e-03 | 6 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 10 | 1.597960e-03 | 6 |
| GO:MF | GO:0030291 | protein serine/threonine kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah] | 3 | 2.098523e-03 | 6 |
| GO:MF | GO:0008353 | RNA polymerase II CTD heptapeptide repeat kinase activity | "Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II." [EC:2.7.11.23, GOC:mah, PMID:28248323] | 2 | 1.074130e-02 | 6 |
| GO:MF | GO:0004860 | protein kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a protein kinase." [GOC:ai] | 3 | 1.302763e-02 | 6 |
| GO:MF | GO:0019210 | kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a kinase." [GOC:mah] | 3 | 1.580424e-02 | 6 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP179 | Cell cycle | Cell cycle | 16 | 1.157761e-26 | 6 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 14 | 1.136713e-25 | 6 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 13 | 5.726526e-21 | 6 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 12 | 5.252454e-20 | 6 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 12 | 1.092710e-19 | 6 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 8 | 2.366713e-10 | 6 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 8 | 7.964605e-10 | 6 |
| WP | WP:WP5497 | Cyclin dependent kinase 4 6 inhibitors in breast cancer | Cyclin dependent kinase 4 6 inhibitors in breast cancer | 6 | 1.103122e-08 | 6 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 11 | 6.503942e-08 | 6 |
| WP | WP:WP1545 | miRNAs involved in DNA damage response | miRNAs involved in DNA damage response | 6 | 4.221347e-07 | 6 |
| WP | WP:WP4630 | Measles virus infection | Measles virus infection | 7 | 7.202940e-07 | 6 |
| WP | WP:WP1971 | Integrated cancer pathway | Integrated cancer pathway | 5 | 2.888775e-06 | 6 |
| WP | WP:WP5300 | TROP2 regulatory signaling | TROP2 regulatory signaling | 5 | 2.888775e-06 | 6 |
| WP | WP:WP3611 | Photodynamic therapy induced AP 1 survival signaling | Photodynamic therapy induced AP 1 survival signaling | 5 | 5.594030e-06 | 6 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 6 | 9.238649e-06 | 6 |
| WP | WP:WP2032 | Thyroid stimulating hormone TSH signaling | Thyroid stimulating hormone TSH signaling | 5 | 1.197817e-05 | 6 |
| WP | WP:WP4172 | PI3K Akt signaling | PI3K Akt signaling | 8 | 1.890876e-05 | 6 |
| WP | WP:WP4685 | Melanoma | Melanoma | 5 | 2.691303e-05 | 6 |
| WP | WP:WP4255 | Non small cell lung cancer | Non small cell lung cancer | 5 | 3.594404e-05 | 6 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 5 | 4.128027e-05 | 6 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 5 | 9.865684e-05 | 6 |
| WP | WP:WP2516 | ATM signaling | ATM signaling | 4 | 1.104445e-04 | 6 |
| WP | WP:WP2828 | Bladder cancer | Bladder cancer | 4 | 1.522408e-04 | 6 |
| WP | WP:WP3941 | Oxidative damage response | Oxidative damage response | 4 | 1.522408e-04 | 6 |
| WP | WP:WP5491 | Transcriptional regulation of memory B cell differentiation | Transcriptional regulation of memory B cell differentiation | 4 | 2.697548e-04 | 6 |
| WP | WP:WP3998 | Prader Willi and Angelman syndrome | Prader Willi and Angelman syndrome | 5 | 2.738031e-04 | 6 |
| WP | WP:WP710 | DNA damage response only ATM dependent | DNA damage response only ATM dependent | 5 | 2.866090e-04 | 6 |
| WP | WP:WP3391 | Senescence associated secretory phenotype SASP | Senescence associated secretory phenotype SASP | 5 | 3.278834e-04 | 6 |
| WP | WP:WP3969 | H19 Rb E2F1 and CDK beta catenin in colorectal cancer | H19 Rb E2F1 and CDK beta catenin in colorectal cancer | 3 | 3.651727e-04 | 6 |
| WP | WP:WP2431 | Spinal cord injury | Spinal cord injury | 5 | 3.737078e-04 | 6 |
| WP | WP:WP4970 | Galanin receptor pathway | Galanin receptor pathway | 3 | 5.603602e-04 | 6 |
| WP | WP:WP5180 | DYRK1A involvement regarding cell proliferation in brain development | DYRK1A involvement regarding cell proliferation in brain development | 4 | 9.034043e-04 | 6 |
| WP | WP:WP4262 | Breast cancer pathway | Breast cancer pathway | 5 | 1.567745e-03 | 6 |
| WP | WP:WP2572 | Primary focal segmental glomerulosclerosis FSGS | Primary focal segmental glomerulosclerosis FSGS | 4 | 1.644816e-03 | 6 |
| WP | WP:WP5087 | Pleural mesothelioma | Pleural mesothelioma | 7 | 1.962693e-03 | 6 |
| WP | WP:WP2878 | PPAR alpha pathway | PPAR alpha pathway | 3 | 2.568408e-03 | 6 |
| WP | WP:WP5121 | Sphingolipid metabolism in senescence | Sphingolipid metabolism in senescence | 3 | 3.227876e-03 | 6 |
| WP | WP:WP4204 | Tumor suppressor activity of SMARCB1 | Tumor suppressor activity of SMARCB1 | 3 | 4.411904e-03 | 6 |
| WP | WP:WP3981 | miRNA regulation of prostate cancer signaling | miRNA regulation of prostate cancer signaling | 3 | 4.411904e-03 | 6 |
| WP | WP:WP4258 | lncRNA in canonical Wnt signaling and colorectal cancer | lncRNA in canonical Wnt signaling and colorectal cancer | 4 | 5.364368e-03 | 6 |
| WP | WP:WP5358 | JAK STAT signaling in the regulation of beta cells | JAK STAT signaling in the regulation of beta cells | 3 | 5.850747e-03 | 6 |
| WP | WP:WP615 | Senescence and autophagy in cancer | Senescence and autophagy in cancer | 4 | 7.325135e-03 | 6 |
| WP | WP:WP34 | Ovarian infertility | Ovarian infertility | 3 | 8.878180e-03 | 6 |
| WP | WP:WP2586 | Aryl hydrocarbon receptor pathway | Aryl hydrocarbon receptor pathway | 3 | 1.461453e-02 | 6 |
| WP | WP:WP2004 | miR targeted genes in lymphocytes | miR targeted genes in lymphocytes | 6 | 1.885336e-02 | 6 |
| WP | WP:WP4879 | Overlap between signal transduction pathways contributing to LMNA laminopathies | Overlap between signal transduction pathways contributing to LMNA laminopathies | 3 | 2.777404e-02 | 6 |
| WP | WP:WP1984 | Integrated breast cancer pathway | Integrated breast cancer pathway | 4 | 3.082995e-02 | 6 |
| WP | WP:WP1403 | AMP activated protein kinase signaling | AMP activated protein kinase signaling | 3 | 4.489069e-02 | 6 |
| WP | WP:WP2882 | Nuclear receptors meta pathway | Nuclear receptors meta pathway | 5 | 4.604190e-02 | 6 |
| WP | WP:WP5158 | Urotensin II mediated signaling | Urotensin II mediated signaling | 3 | 4.897101e-02 | 6 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 16 | 2.366650e-26 | 6 |
| REAC | REAC:R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 10 | 3.752035e-23 | 6 |
| REAC | REAC:R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 10 | 3.752035e-23 | 6 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 12 | 4.610486e-23 | 6 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 12 | 4.610486e-23 | 6 |
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 11 | 8.350773e-22 | 6 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 11 | 1.670578e-21 | 6 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 12 | 2.682640e-17 | 6 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 16 | 5.268296e-17 | 6 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 16 | 1.609632e-15 | 6 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 9 | 6.574665e-13 | 6 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 9 | 8.246969e-13 | 6 |
| REAC | REAC:R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | Drug-mediated inhibition of CDK4/CDK6 activity | 5 | 2.018438e-12 | 6 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 10 | 4.526708e-12 | 6 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 16 | 2.227817e-11 | 6 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 16 | 9.807591e-11 | 6 |
| REAC | REAC:R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | TP53 Regulates Transcription of Cell Cycle Genes | 7 | 2.155141e-10 | 6 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 16 | 5.905295e-10 | 6 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 7 | 9.596289e-10 | 6 |
| REAC | REAC:R-HSA-8849470 | PTK6 Regulates Cell Cycle | PTK6 Regulates Cell Cycle | 4 | 2.374032e-08 | 6 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 7 | 1.244804e-07 | 6 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 9 | 4.498116e-07 | 6 |
| REAC | REAC:R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 4 | 1.571409e-06 | 6 |
| REAC | REAC:R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | Regulation of RUNX1 Expression and Activity | 4 | 3.724813e-06 | 6 |
| REAC | REAC:R-HSA-2559583 | Cellular Senescence | Cellular Senescence | 7 | 4.060249e-06 | 6 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 14 | 6.469729e-06 | 6 |
| REAC | REAC:R-HSA-1538133 | G0 and Early G1 | G0 and Early G1 | 4 | 2.318381e-05 | 6 |
| REAC | REAC:R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | Cyclin A/B1/B2 associated events during G2/M transition | 4 | 2.318381e-05 | 6 |
| REAC | REAC:R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | DNA Damage/Telomere Stress Induced Senescence | 5 | 4.228582e-05 | 6 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 5 | 7.285166e-05 | 6 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 5 | 7.285166e-05 | 6 |
| REAC | REAC:R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | Senescence-Associated Secretory Phenotype (SASP) | 5 | 2.329708e-04 | 6 |
| REAC | REAC:R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3 | 3.292634e-04 | 6 |
| REAC | REAC:R-HSA-8848021 | Signaling by PTK6 | Signaling by PTK6 | 4 | 3.777783e-04 | 6 |
| REAC | REAC:R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | Signaling by Non-Receptor Tyrosine Kinases | 4 | 3.777783e-04 | 6 |
| REAC | REAC:R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3 | 9.346428e-04 | 6 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 4 | 1.072974e-03 | 6 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 4 | 1.072974e-03 | 6 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 4 | 1.209945e-03 | 6 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 6 | 1.402813e-03 | 6 |
| REAC | REAC:R-HSA-113510 | E2F mediated regulation of DNA replication | E2F mediated regulation of DNA replication | 3 | 2.018144e-03 | 6 |
| REAC | REAC:R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 2 | 2.397025e-03 | 6 |
| REAC | REAC:R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 | 2 | 2.397025e-03 | 6 |
| REAC | REAC:R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 2 | 2.397025e-03 | 6 |
| REAC | REAC:R-HSA-9630747 | Diseases of Cellular Senescence | Diseases of Cellular Senescence | 2 | 2.397025e-03 | 6 |
| REAC | REAC:R-HSA-9675132 | Diseases of cellular response to stress | Diseases of cellular response to stress | 2 | 2.397025e-03 | 6 |
| REAC | REAC:R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 | 2 | 2.397025e-03 | 6 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 3 | 3.319571e-03 | 6 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 5 | 3.825251e-03 | 6 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 5 | 4.018545e-03 | 6 |
| REAC | REAC:R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | 2 | 4.789403e-03 | 6 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 8 | 5.215047e-03 | 6 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 8 | 5.927755e-03 | 6 |
| REAC | REAC:R-HSA-2559585 | Oncogene Induced Senescence | Oncogene Induced Senescence | 3 | 6.154092e-03 | 6 |
| REAC | REAC:R-HSA-69478 | G2/M DNA replication checkpoint | G2/M DNA replication checkpoint | 2 | 7.974600e-03 | 6 |
| REAC | REAC:R-HSA-8878171 | Transcriptional regulation by RUNX1 | Transcriptional regulation by RUNX1 | 5 | 9.009033e-03 | 6 |
| REAC | REAC:R-HSA-176417 | Phosphorylation of Emi1 | Phosphorylation of Emi1 | 2 | 1.195031e-02 | 6 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 4 | 1.195648e-02 | 6 |
| REAC | REAC:R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 2 | 1.671421e-02 | 6 |
| REAC | REAC:R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | E2F-enabled inhibition of pre-replication complex formation | 2 | 2.859742e-02 | 6 |
| REAC | REAC:R-HSA-2465910 | MASTL Facilitates Mitotic Progression | MASTL Facilitates Mitotic Progression | 2 | 3.571213e-02 | 6 |
| REAC | REAC:R-HSA-2514853 | Condensation of Prometaphase Chromosomes | Condensation of Prometaphase Chromosomes | 2 | 4.360585e-02 | 6 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 16 | 8.908936e-26 | 6 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 12 | 7.695502e-15 | 6 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 11 | 3.652289e-14 | 6 |
| KEGG | KEGG:04115 | p53 signaling pathway | p53 signaling pathway | 9 | 2.489557e-13 | 6 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 11 | 5.685567e-13 | 6 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 8 | 1.927341e-10 | 6 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 10 | 6.473303e-09 | 6 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 11 | 2.583815e-08 | 6 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 8 | 2.038929e-07 | 6 |
| KEGG | KEGG:05162 | Measles | Measles | 7 | 2.687828e-07 | 6 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 6 | 2.962041e-07 | 6 |
| KEGG | KEGG:04934 | Cushing syndrome | Cushing syndrome | 7 | 5.532951e-07 | 6 |
| KEGG | KEGG:04068 | FoxO signaling pathway | FoxO signaling pathway | 6 | 7.961105e-06 | 6 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 8 | 9.490039e-06 | 6 |
| KEGG | KEGG:05218 | Melanoma | Melanoma | 5 | 1.337950e-05 | 6 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | Non-small cell lung cancer | 5 | 1.337950e-05 | 6 |
| KEGG | KEGG:05214 | Glioma | Glioma | 5 | 1.644581e-05 | 6 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 5 | 1.758310e-05 | 6 |
| KEGG | KEGG:01522 | Endocrine resistance | Endocrine resistance | 5 | 5.391472e-05 | 6 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 5 | 5.982599e-05 | 6 |
| KEGG | KEGG:05219 | Bladder cancer | Bladder cancer | 4 | 6.534098e-05 | 6 |
| KEGG | KEGG:05224 | Breast cancer | Breast cancer | 5 | 4.671151e-04 | 6 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 5 | 4.828722e-04 | 6 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 5 | 6.645504e-04 | 6 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 5 | 7.506510e-04 | 6 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 5 | 8.452588e-04 | 6 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | MicroRNAs in cancer | 6 | 1.221301e-03 | 6 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 5 | 1.797964e-03 | 6 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 5 | 3.509025e-03 | 6 |
| KEGG | KEGG:04630 | JAK-STAT signaling pathway | JAK-STAT signaling pathway | 4 | 1.536656e-02 | 6 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | Transcriptional misregulation in cancer | 4 | 2.938698e-02 | 6 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 14 | 5.757653e-22 | 6 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 14 | 3.729538e-21 | 6 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 15 | 1.720615e-19 | 6 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 17 | 9.090028e-19 | 6 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 19 | 1.507259e-18 | 6 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 15 | 4.631630e-18 | 6 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 16 | 6.613024e-18 | 6 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 17 | 2.644340e-17 | 6 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 13 | 8.748484e-17 | 6 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 14 | 1.834579e-16 | 6 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 13 | 2.893981e-15 | 6 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 16 | 3.785701e-14 | 6 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 13 | 8.015936e-13 | 6 |
| GO:BP | GO:0000086 | G2/M transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] | 9 | 2.314462e-12 | 6 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 13 | 2.567283e-12 | 6 |
| GO:BP | GO:0044839 | cell cycle G2/M phase transition | "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle] | 9 | 6.683597e-12 | 6 |
| GO:BP | GO:1901992 | positive regulation of mitotic cell cycle phase transition | "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 8 | 1.117086e-11 | 6 |
| GO:BP | GO:1901989 | positive regulation of cell cycle phase transition | "Any process that activates or increases the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 8 | 5.977695e-11 | 6 |
| GO:BP | GO:0006468 | protein phosphorylation | "The process of introducing a phosphate group on to a protein." [GOC:hb] | 14 | 6.236950e-11 | 6 |
| GO:BP | GO:0045931 | positive regulation of mitotic cell cycle | "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 8 | 1.190205e-10 | 6 |
| GO:BP | GO:0016310 | phosphorylation | "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] | 14 | 1.705991e-10 | 6 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 17 | 3.068483e-10 | 6 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 8 | 5.615007e-10 | 6 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 17 | 8.758985e-10 | 6 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 8 | 2.050200e-09 | 6 |
| GO:BP | GO:0010389 | regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565] | 7 | 4.331925e-09 | 6 |
| GO:BP | GO:1902749 | regulation of cell cycle G2/M phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 7 | 9.969150e-09 | 6 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 9 | 1.962201e-08 | 6 |
| GO:BP | GO:0090068 | positive regulation of cell cycle process | "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 8 | 5.009823e-08 | 6 |
| GO:BP | GO:0008283 | cell population proliferation | "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] | 14 | 5.519844e-08 | 6 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] | 13 | 1.318202e-07 | 6 |
| GO:BP | GO:0045787 | positive regulation of cell cycle | "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] | 8 | 5.124506e-07 | 6 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 14 | 6.083248e-07 | 6 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 14 | 6.185949e-07 | 6 |
| GO:BP | GO:0048144 | fibroblast proliferation | "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] | 6 | 6.196693e-07 | 6 |
| GO:BP | GO:0045930 | negative regulation of mitotic cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 7 | 9.445605e-07 | 6 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 19 | 1.298706e-06 | 6 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 17 | 1.391973e-06 | 6 |
| GO:BP | GO:0048146 | positive regulation of fibroblast proliferation | "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] | 5 | 1.493559e-06 | 6 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] | 10 | 3.206381e-06 | 6 |
| GO:BP | GO:0031100 | animal organ regeneration | "The regrowth of a lost or destroyed animal organ." [GOC:mah] | 5 | 4.884838e-06 | 6 |
| GO:BP | GO:0051338 | regulation of transferase activity | "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] | 8 | 8.039209e-06 | 6 |
| GO:BP | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] | 5 | 1.119044e-05 | 6 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 18 | 1.229788e-05 | 6 |
| GO:BP | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb] | 4 | 1.373617e-05 | 6 |
| GO:BP | GO:0048145 | regulation of fibroblast proliferation | "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] | 5 | 2.034455e-05 | 6 |
| GO:BP | GO:1902751 | positive regulation of cell cycle G2/M phase transition | "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 4 | 2.107294e-05 | 6 |
| GO:BP | GO:0031099 | regeneration | "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass)." [GOC:mah, GOC:pr] | 6 | 2.549443e-05 | 6 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 15 | 3.702944e-05 | 6 |
| GO:BP | GO:0045859 | regulation of protein kinase activity | "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] | 7 | 5.234059e-05 | 6 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 17 | 5.696905e-05 | 6 |
| GO:BP | GO:0071900 | regulation of protein serine/threonine kinase activity | "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] | 6 | 7.470992e-05 | 6 |
| GO:BP | GO:0045740 | positive regulation of DNA replication | "Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators] | 4 | 8.208627e-05 | 6 |
| GO:BP | GO:0043549 | regulation of kinase activity | "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] | 7 | 8.428640e-05 | 6 |
| GO:BP | GO:0006275 | regulation of DNA replication | "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] | 5 | 8.675979e-05 | 6 |
| GO:BP | GO:0009410 | response to xenobiotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:jl, GOC:krc] | 7 | 9.556438e-05 | 6 |
| GO:BP | GO:0050673 | epithelial cell proliferation | "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] | 7 | 9.857555e-05 | 6 |
| GO:BP | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 4 | 9.899097e-05 | 6 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 18 | 1.158391e-04 | 6 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 14 | 1.259260e-04 | 6 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 17 | 1.428066e-04 | 6 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 9 | 1.552326e-04 | 6 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 6 | 1.886448e-04 | 6 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 16 | 2.074715e-04 | 6 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 6 | 2.223653e-04 | 6 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 10 | 2.884415e-04 | 6 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 16 | 3.102363e-04 | 6 |
| GO:BP | GO:1902808 | positive regulation of cell cycle G1/S phase transition | "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 4 | 3.435604e-04 | 6 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 16 | 4.147177e-04 | 6 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 13 | 4.983443e-04 | 6 |
| GO:BP | GO:1901991 | negative regulation of mitotic cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 5 | 5.231822e-04 | 6 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 16 | 6.387722e-04 | 6 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 12 | 7.075358e-04 | 6 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 13 | 7.685603e-04 | 6 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 13 | 8.213936e-04 | 6 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] | 6 | 8.277189e-04 | 6 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 9 | 8.445441e-04 | 6 |
| GO:BP | GO:1904030 | negative regulation of cyclin-dependent protein kinase activity | "Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] | 3 | 8.580750e-04 | 6 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 12 | 9.273679e-04 | 6 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 9 | 9.379908e-04 | 6 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 8 | 9.771483e-04 | 6 |
| GO:BP | GO:1905178 | regulation of cardiac muscle tissue regeneration | "Any process that modulates the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] | 2 | 1.105186e-03 | 6 |
| GO:BP | GO:1905179 | negative regulation of cardiac muscle tissue regeneration | "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] | 2 | 1.105186e-03 | 6 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 13 | 1.242703e-03 | 6 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 10 | 1.541908e-03 | 6 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 8 | 1.785618e-03 | 6 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 9 | 1.796423e-03 | 6 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 13 | 1.955725e-03 | 6 |
| GO:BP | GO:1901988 | negative regulation of cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 5 | 3.182049e-03 | 6 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 12 | 3.289406e-03 | 6 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 18 | 3.713804e-03 | 6 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 15 | 4.494648e-03 | 6 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] | 7 | 4.545935e-03 | 6 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 6 | 5.227325e-03 | 6 |
| GO:BP | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators, GOC:pr] | 3 | 5.253801e-03 | 6 |
| GO:BP | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity | "Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] | 3 | 6.261585e-03 | 6 |
| GO:BP | GO:1905448 | positive regulation of mitochondrial ATP synthesis coupled electron transport | "Any process that activates or increases the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074] | 2 | 6.623969e-03 | 6 |
| GO:BP | GO:0010948 | negative regulation of cell cycle process | "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 5 | 6.722040e-03 | 6 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 12 | 6.791591e-03 | 6 |
| GO:BP | GO:0042325 | regulation of phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] | 7 | 6.914438e-03 | 6 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 15 | 7.324785e-03 | 6 |
| GO:BP | GO:0051347 | positive regulation of transferase activity | "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] | 5 | 7.553180e-03 | 6 |
| GO:BP | GO:0007093 | mitotic cell cycle checkpoint signaling | "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] | 4 | 8.598948e-03 | 6 |
| GO:BP | GO:0050680 | negative regulation of epithelial cell proliferation | "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai] | 4 | 8.852497e-03 | 6 |
| GO:BP | GO:0006469 | negative regulation of protein kinase activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators] | 4 | 9.111535e-03 | 6 |
| GO:BP | GO:0007165 | signal transduction | "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] | 15 | 1.077413e-02 | 6 |
| GO:BP | GO:0033673 | negative regulation of kinase activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] | 4 | 1.108497e-02 | 6 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 7 | 1.239335e-02 | 6 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 7 | 1.248320e-02 | 6 |
| GO:BP | GO:1905446 | regulation of mitochondrial ATP synthesis coupled electron transport | "Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074] | 2 | 1.654208e-02 | 6 |
| GO:BP | GO:0061026 | cardiac muscle tissue regeneration | "The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:dph] | 2 | 1.654208e-02 | 6 |
| GO:BP | GO:0031400 | negative regulation of protein modification process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 5 | 1.679460e-02 | 6 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 7 | 1.748578e-02 | 6 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] | 7 | 1.760554e-02 | 6 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 9 | 1.848632e-02 | 6 |
| GO:BP | GO:0051348 | negative regulation of transferase activity | "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] | 4 | 1.936706e-02 | 6 |
| GO:BP | GO:0008608 | attachment of spindle microtubules to kinetochore | "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137] | 3 | 2.153002e-02 | 6 |
| GO:BP | GO:0030308 | negative regulation of cell growth | "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] | 4 | 2.276622e-02 | 6 |
| GO:BP | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 2.403366e-02 | 6 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 8 | 2.891783e-02 | 6 |
| GO:BP | GO:0000075 | cell cycle checkpoint signaling | "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] | 4 | 2.896996e-02 | 6 |
| GO:BP | GO:0046686 | response to cadmium ion | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:ai] | 3 | 2.960158e-02 | 6 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 19 | 3.069491e-02 | 6 |
| GO:BP | GO:1902807 | negative regulation of cell cycle G1/S phase transition | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 3.111493e-02 | 6 |
| GO:BP | GO:0023052 | signaling | "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] | 15 | 3.254544e-02 | 6 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 8 | 3.304701e-02 | 6 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 8 | 3.419562e-02 | 6 |
| GO:BP | GO:0007154 | cell communication | "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] | 15 | 3.425740e-02 | 6 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 8 | 3.589508e-02 | 6 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 9 | 3.936776e-02 | 6 |
| GO:BP | GO:0044773 | mitotic DNA damage checkpoint signaling | "A signal transduction process involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 4.708256e-02 | 6 |
| GO:BP | GO:0009314 | response to radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] | 5 | 4.949445e-02 | 6 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:313 | Cell cycle kinase complex CDK5 | Cell cycle kinase complex CDK5 | 3 | 0.000006 | 6 |
| CORUM | CORUM:310 | Cell cycle kinase complex CDC2 | Cell cycle kinase complex CDC2 | 3 | 0.000025 | 6 |
| CORUM | CORUM:1633 | CyclinD1-CDK4-CDK6 complex | CyclinD1-CDK4-CDK6 complex | 2 | 0.002392 | 6 |
| CORUM | CORUM:3087 | CCND1-CDK6 complex | CCND1-CDK6 complex | 2 | 0.002392 | 6 |
| CORUM | CORUM:5557 | CDC2-CCNA2 complex | CDC2-CCNA2 complex | 2 | 0.002392 | 6 |
| CORUM | CORUM:5101 | CyclinD3-CDK4-CDK6-p21 complex | CyclinD3-CDK4-CDK6-p21 complex | 2 | 0.002392 | 6 |
| CORUM | CORUM:311 | Cell cycle kinase complex CDK2 | Cell cycle kinase complex CDK2 | 2 | 0.002392 | 6 |
| CORUM | CORUM:1634 | CyclinD1-CDK4-p21 complex | CyclinD1-CDK4-p21 complex | 2 | 0.002392 | 6 |
| CORUM | CORUM:5559 | CDC2-CCNA2-CDK2 complex | CDC2-CCNA2-CDK2 complex | 2 | 0.002392 | 6 |
| CORUM | CORUM:312 | Cell cycle kinase complex CDK4 | Cell cycle kinase complex CDK4 | 2 | 0.002392 | 6 |
| CORUM | CORUM:6300 | CDKN1A-TP53-CDK1-PCNA complex | CDKN1A-TP53-CDK1-PCNA complex | 2 | 0.007162 | 6 |
| CORUM | CORUM:3015 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | 2 | 0.035620 | 6 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-195-5p | hsa-mir-195-5p | hsa-mir-195-5p | 8 | 0.000089 | 6 |
| MIRNA | MIRNA:hsa-mir-497-5p | hsa-mir-497-5p | hsa-mir-497-5p | 7 | 0.000156 | 6 |
| MIRNA | MIRNA:hsa-mir-29a-3p | hsa-mir-29a-3p | hsa-mir-29a-3p | 5 | 0.002763 | 6 |
| MIRNA | MIRNA:hsa-mir-503-5p | hsa-mir-503-5p | hsa-mir-503-5p | 5 | 0.003545 | 6 |
| MIRNA | MIRNA:hsa-mir-424-5p | hsa-mir-424-5p | hsa-mir-424-5p | 6 | 0.003938 | 6 |
| MIRNA | MIRNA:hsa-mir-15b-5p | hsa-mir-15b-5p | hsa-mir-15b-5p | 7 | 0.005045 | 6 |
| MIRNA | MIRNA:hsa-mir-24-3p | hsa-mir-24-3p | hsa-mir-24-3p | 7 | 0.008392 | 6 |
| MIRNA | MIRNA:hsa-let-7b-5p | hsa-let-7b-5p | hsa-let-7b-5p | 8 | 0.010653 | 6 |
| MIRNA | MIRNA:hsa-mir-145-3p | hsa-mir-145-3p | hsa-mir-145-3p | 3 | 0.025633 | 6 |
| MIRNA | MIRNA:hsa-mir-6838-5p | hsa-mir-6838-5p | hsa-mir-6838-5p | 5 | 0.038673 | 6 |
| MIRNA | MIRNA:hsa-mir-15a-5p | hsa-mir-15a-5p | hsa-mir-15a-5p | 6 | 0.042089 | 6 |
| MIRNA | MIRNA:hsa-mir-541-5p | hsa-mir-541-5p | hsa-mir-541-5p | 3 | 0.042142 | 6 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0008261 | Pancreatic islet cell adenoma | The presence of an adenoma of the pancreas with origin in a pancreatic B cell. | 3 | 0.000604 | 6 |
| HP | HP:0100631 | Neoplasm of the adrenal gland | A tumor (abnormal growth of tissue) of the adrenal gland. | 4 | 0.001563 | 6 |
| HP | HP:0030405 | Pancreatic endocrine tumor | A neuroendocrine tumor originating in a hormone-producing cell (islet cell) of the pancreas. | 3 | 0.002047 | 6 |
| HP | HP:0006744 | Adrenocortical carcinoma | A malignant neoplasm of the adrenal cortex that may produce hormones such as cortisol, aldosterone, estrogen, or testosterone. | 3 | 0.005809 | 6 |
| HP | HP:0003072 | Hypercalcemia | An abnormally increased calcium concentration in the blood. | 4 | 0.015416 | 6 |
| HP | HP:0002894 | Neoplasm of the pancreas | A tumor (abnormal growth of tissue) of the pancreas. | 4 | 0.020507 | 6 |
| HP | HP:0002797 | Osteolysis | Osteolysis refers to the destruction of bone through bone resorption with removal or loss of calcium. | 4 | 0.020507 | 6 |
| HP | HP:0100641 | Neoplasm of the adrenal cortex | The presence of a neoplasm of the adrenal cortex. | 3 | 0.020631 | 6 |
| HP | HP:0002666 | Pheochromocytoma | Pheochromocytomas (also known as chromaffin tumors) produce, store, and secrete catecholamines. Pheochromocytomas usually originate from the adrenal medulla but may also develop from chromaffin cells in or about sympathetic ganglia. A common symptom of pheochromocytoma is hypertension owing to release of catecholamines. | 3 | 0.023083 | 6 |
| HP | HP:0006476 | Abnormality of the pancreatic islet cells | An abnormality of the islet of Langerhans, i.e., of the regions of the pancreas that contain its endocrine cells. These are the alpha cells, which produce glucagon, the beta cells, which produce insulin and amylin, the delta cells, which produce somatostatin, the PP cells, which produce pancreatic polypeptide, and the epsilon cells, which produce ghrelin. | 3 | 0.023083 | 6 |
| HP | HP:0011792 | Neoplasm by histology | Neoplasm categorized according to type of histological abnormality. | 6 | 0.024668 | 6 |
| HP | HP:0012093 | Abnormality of endocrine pancreas physiology | A function abnormality of the endocrine pancreas. | 3 | 0.031573 | 6 |
| HP | HP:0011761 | Pituitary null cell adenoma | A type of pituitary adenoma that is of unknown cellular origin and that lacks immunocytochemical or fine structural markers. Null cell adenomas are not associated with hormone excess. | 2 | 0.045753 | 6 |
| HP | HP:0011762 | Pituitary thyrotropic cell adenoma | A type of pituitary adenoma that produces thyroid stimulating hormone (TSH). | 2 | 0.045753 | 6 |
| HP | HP:0011759 | Pituitary gonadotropic cell adenoma | A type of pituitary adenoma that produces gonadotropins. | 2 | 0.045753 | 6 |
| HP | HP:0040306 | Decreased male libido | Reduced desire for sexual activity on the part of a male. | 2 | 0.045753 | 6 |
| HP | HP:0100522 | Thymoma | A tumor originating from the epithelial cells of the thymus. | 2 | 0.045753 | 6 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00425_1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | 16 | 0.000745 | 6 |
| TF | TF:M00516 | Factor: E2F-1; motif: TTTSGCGCGMNR | Factor: E2F-1; motif: TTTSGCGCGMNR | 16 | 0.032653 | 6 |
| TF | TF:M00427 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 18 | 0.046933 | 6 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 7 | 0.028694 | 6 |
Community 7
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-72163 | mRNA Splicing - Major Pathway | mRNA Splicing - Major Pathway | 8 | 4.337758e-09 | 7 |
| REAC | REAC:R-HSA-72172 | mRNA Splicing | mRNA Splicing | 8 | 5.707469e-09 | 7 |
| REAC | REAC:R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | Processing of Capped Intron-Containing Pre-mRNA | 8 | 5.308793e-08 | 7 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 8 | 9.034906e-05 | 7 |
| REAC | REAC:R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins | SUMO E3 ligases SUMOylate target proteins | 5 | 3.323870e-04 | 7 |
| REAC | REAC:R-HSA-2990846 | SUMOylation | SUMOylation | 5 | 3.938870e-04 | 7 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP411 | mRNA processing | mRNA processing | 7 | 1.090286e-08 | 7 |
| WP | WP:WP3594 | Circadian rhythm genes | Circadian rhythm genes | 6 | 1.467887e-05 | 7 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 10 | 1.389322e-08 | 7 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 8 | 4.153378e-08 | 7 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 10 | 4.932409e-08 | 7 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 10 | 5.490980e-08 | 7 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 10 | 6.882685e-08 | 7 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 8 | 8.969463e-08 | 7 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 10 | 9.360881e-08 | 7 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 10 | 1.389746e-07 | 7 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 10 | 1.488829e-07 | 7 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 10 | 1.572594e-07 | 7 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 10 | 1.660552e-07 | 7 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 9 | 2.087146e-07 | 7 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 10 | 2.673501e-07 | 7 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 7 | 3.450123e-07 | 7 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 10 | 3.858668e-07 | 7 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 10 | 4.528047e-07 | 7 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 9 | 4.878573e-07 | 7 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 7 | 4.952262e-07 | 7 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 9 | 6.360337e-07 | 7 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 10 | 6.560975e-07 | 7 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 9 | 6.659473e-07 | 7 |
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 8 | 6.743071e-07 | 7 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 9 | 8.225921e-07 | 7 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 7 | 9.673476e-07 | 7 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 10 | 1.014147e-06 | 7 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 7 | 1.024799e-06 | 7 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 10 | 1.133566e-06 | 7 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 10 | 1.211102e-06 | 7 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 7 | 1.214907e-06 | 7 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 7 | 1.214907e-06 | 7 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 7 | 1.214907e-06 | 7 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 11 | 1.326156e-06 | 7 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 9 | 1.590334e-06 | 7 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 10 | 1.710361e-06 | 7 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 9 | 1.924746e-06 | 7 |
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 9 | 2.229499e-06 | 7 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 10 | 2.667910e-06 | 7 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 9 | 4.217764e-06 | 7 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 10 | 4.752399e-06 | 7 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 9 | 6.265084e-06 | 7 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 9 | 6.956889e-06 | 7 |
| HPA | HPA:0090183 | Cerebellum; cells in granular layer[High] | Cerebellum; cells in granular layer[High] | 9 | 7.037756e-06 | 7 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 10 | 9.024544e-06 | 7 |
| HPA | HPA:0471492 | Skin 2; vascular mural cells[≥Medium] | Skin 2; vascular mural cells[≥Medium] | 6 | 1.040236e-05 | 7 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 9 | 1.140044e-05 | 7 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 11 | 1.348987e-05 | 7 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 10 | 1.550568e-05 | 7 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 12 | 1.735294e-05 | 7 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 9 | 1.779987e-05 | 7 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 8 | 2.251341e-05 | 7 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 9 | 2.852638e-05 | 7 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 7 | 2.947886e-05 | 7 |
| HPA | HPA:0471493 | Skin 2; vascular mural cells[High] | Skin 2; vascular mural cells[High] | 5 | 5.613206e-05 | 7 |
| HPA | HPA:0461493 | Skin 1; vascular mural cells[High] | Skin 1; vascular mural cells[High] | 5 | 7.041585e-05 | 7 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 7 | 7.852826e-05 | 7 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 10 | 1.557865e-04 | 7 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 9 | 1.886505e-04 | 7 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 6 | 1.971488e-04 | 7 |
| HPA | HPA:0351183 | Pancreas; pancreatic endocrine cells[High] | Pancreas; pancreatic endocrine cells[High] | 8 | 2.322586e-04 | 7 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 11 | 2.663411e-04 | 7 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 7 | 2.930892e-04 | 7 |
| HPA | HPA:0270353 | Kidney; cells in glomeruli[High] | Kidney; cells in glomeruli[High] | 8 | 3.712099e-04 | 7 |
| HPA | HPA:0461492 | Skin 1; vascular mural cells[≥Medium] | Skin 1; vascular mural cells[≥Medium] | 5 | 3.728414e-04 | 7 |
| HPA | HPA:0461393 | Skin 1; cells in basal layer[High] | Skin 1; cells in basal layer[High] | 5 | 3.926694e-04 | 7 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 9 | 4.084838e-04 | 7 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 9 | 4.661658e-04 | 7 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 10 | 4.749404e-04 | 7 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 8 | 4.865848e-04 | 7 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 7 | 7.469864e-04 | 7 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 8 | 7.864574e-04 | 7 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 8 | 8.315824e-04 | 7 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 6 | 8.582901e-04 | 7 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 11 | 1.012528e-03 | 7 |
| HPA | HPA:0080123 | Caudate; glial cells[High] | Caudate; glial cells[High] | 7 | 1.211510e-03 | 7 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 10 | 1.355375e-03 | 7 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 7 | 1.385567e-03 | 7 |
| HPA | HPA:0570793 | Testis; round or early spermatids[High] | Testis; round or early spermatids[High] | 8 | 1.538313e-03 | 7 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 10 | 1.589988e-03 | 7 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 11 | 1.820627e-03 | 7 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 9 | 2.125968e-03 | 7 |
| HPA | HPA:0570783 | Testis; preleptotene spermatocytes[High] | Testis; preleptotene spermatocytes[High] | 7 | 2.246573e-03 | 7 |
| HPA | HPA:0030073 | Appendix; lymphoid tissue[High] | Appendix; lymphoid tissue[High] | 7 | 2.536955e-03 | 7 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 11 | 2.570355e-03 | 7 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 10 | 2.873017e-03 | 7 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 11 | 2.921591e-03 | 7 |
| HPA | HPA:0400053 | Rectum; glandular cells[High] | Rectum; glandular cells[High] | 11 | 2.992018e-03 | 7 |
| HPA | HPA:0461452 | Skin 1; hair follicles[≥Medium] | Skin 1; hair follicles[≥Medium] | 5 | 3.166339e-03 | 7 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 8 | 3.255850e-03 | 7 |
| HPA | HPA:0510653 | Soft tissue 2; fibroblasts[High] | Soft tissue 2; fibroblasts[High] | 6 | 3.538019e-03 | 7 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 13 | 3.598712e-03 | 7 |
| HPA | HPA:0570772 | Testis; peritubular cells[≥Medium] | Testis; peritubular cells[≥Medium] | 6 | 3.735638e-03 | 7 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 11 | 4.512838e-03 | 7 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 5 | 4.842680e-03 | 7 |
| HPA | HPA:0530723 | Spleen; cells in white pulp[High] | Spleen; cells in white pulp[High] | 7 | 5.019410e-03 | 7 |
| HPA | HPA:0130203 | Colon; endothelial cells[High] | Colon; endothelial cells[High] | 7 | 5.215296e-03 | 7 |
| HPA | HPA:0270363 | Kidney; cells in tubules[High] | Kidney; cells in tubules[High] | 10 | 5.699857e-03 | 7 |
| HPA | HPA:0461482 | Skin 1; sebaceous glands[≥Medium] | Skin 1; sebaceous glands[≥Medium] | 4 | 6.458987e-03 | 7 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 13 | 7.315727e-03 | 7 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 12 | 7.546421e-03 | 7 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 5 | 8.074001e-03 | 7 |
| HPA | HPA:0170253 | Endometrium 2; cells in endometrial stroma[High] | Endometrium 2; cells in endometrial stroma[High] | 5 | 8.293111e-03 | 7 |
| HPA | HPA:0461451 | Skin 1; hair follicles[≥Low] | Skin 1; hair follicles[≥Low] | 5 | 9.337022e-03 | 7 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 10 | 9.526883e-03 | 7 |
| HPA | HPA:0600443 | Tonsil; non-germinal center cells[High] | Tonsil; non-germinal center cells[High] | 8 | 9.865561e-03 | 7 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 8 | 1.042301e-02 | 7 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 9 | 1.050139e-02 | 7 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 9 | 1.129479e-02 | 7 |
| HPA | HPA:0300413 | Lung; macrophages[High] | Lung; macrophages[High] | 8 | 1.272380e-02 | 7 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 7 | 1.314110e-02 | 7 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 12 | 1.349504e-02 | 7 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 9 | 1.350809e-02 | 7 |
| HPA | HPA:0461481 | Skin 1; sebaceous glands[≥Low] | Skin 1; sebaceous glands[≥Low] | 4 | 1.421575e-02 | 7 |
| HPA | HPA:0030053 | Appendix; glandular cells[High] | Appendix; glandular cells[High] | 9 | 1.594705e-02 | 7 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 10 | 1.651489e-02 | 7 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 11 | 1.723735e-02 | 7 |
| HPA | HPA:0570762 | Testis; pachytene spermatocytes[≥Medium] | Testis; pachytene spermatocytes[≥Medium] | 9 | 1.730245e-02 | 7 |
| HPA | HPA:0570781 | Testis; preleptotene spermatocytes[≥Low] | Testis; preleptotene spermatocytes[≥Low] | 9 | 1.737645e-02 | 7 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 7 | 1.805402e-02 | 7 |
| HPA | HPA:0570792 | Testis; round or early spermatids[≥Medium] | Testis; round or early spermatids[≥Medium] | 9 | 1.828591e-02 | 7 |
| HPA | HPA:0270352 | Kidney; cells in glomeruli[≥Medium] | Kidney; cells in glomeruli[≥Medium] | 11 | 1.869667e-02 | 7 |
| HPA | HPA:0570773 | Testis; peritubular cells[High] | Testis; peritubular cells[High] | 4 | 1.876368e-02 | 7 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 8 | 1.968317e-02 | 7 |
| HPA | HPA:0160253 | Endometrium 1; cells in endometrial stroma[High] | Endometrium 1; cells in endometrial stroma[High] | 5 | 2.091987e-02 | 7 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 8 | 2.129958e-02 | 7 |
| HPA | HPA:0570771 | Testis; peritubular cells[≥Low] | Testis; peritubular cells[≥Low] | 6 | 2.250833e-02 | 7 |
| HPA | HPA:0530712 | Spleen; cells in red pulp[≥Medium] | Spleen; cells in red pulp[≥Medium] | 11 | 2.258296e-02 | 7 |
| HPA | HPA:0050012 | Breast; adipocytes[≥Medium] | Breast; adipocytes[≥Medium] | 8 | 2.313833e-02 | 7 |
| HPA | HPA:0570782 | Testis; preleptotene spermatocytes[≥Medium] | Testis; preleptotene spermatocytes[≥Medium] | 8 | 2.325053e-02 | 7 |
| HPA | HPA:0010013 | Adipose tissue; adipocytes[High] | Adipose tissue; adipocytes[High] | 5 | 2.694024e-02 | 7 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 5 | 2.892541e-02 | 7 |
| HPA | HPA:0380203 | Placenta; endothelial cells[High] | Placenta; endothelial cells[High] | 4 | 2.949553e-02 | 7 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 12 | 3.033028e-02 | 7 |
| HPA | HPA:0360053 | Parathyroid gland; glandular cells[High] | Parathyroid gland; glandular cells[High] | 8 | 3.087788e-02 | 7 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 13 | 3.465826e-02 | 7 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 12 | 3.909519e-02 | 7 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 13 | 4.052959e-02 | 7 |
| HPA | HPA:0630053 | Cervix; glandular cells[High] | Cervix; glandular cells[High] | 7 | 4.151162e-02 | 7 |
| HPA | HPA:0530713 | Spleen; cells in red pulp[High] | Spleen; cells in red pulp[High] | 6 | 4.501507e-02 | 7 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 10 | 4.563688e-02 | 7 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 13 | 4.775514e-02 | 7 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 7 | 4.786109e-02 | 7 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 8 | 4.949968e-02 | 7 |
| HPA | HPA:0050093 | Breast; myoepithelial cells[High] | Breast; myoepithelial cells[High] | 6 | 4.970304e-02 | 7 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 14 | 1.554941e-07 | 7 |
| GO:CC | GO:0071013 | catalytic step 2 spliceosome | "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 5 | 4.194162e-07 | 7 |
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 6 | 4.341952e-07 | 7 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 14 | 5.871789e-06 | 7 |
| GO:CC | GO:0016607 | nuclear speck | "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640] | 6 | 2.638695e-05 | 7 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 14 | 7.814189e-05 | 7 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 14 | 7.814189e-05 | 7 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 14 | 7.814189e-05 | 7 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 6 | 2.143079e-03 | 7 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 8 | 2.170422e-03 | 7 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 13 | 1.060457e-02 | 7 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 7 | 1.060472e-02 | 7 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 14 | 1.929546e-02 | 7 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 8 | 2.062475e-02 | 7 |
| GO:CC | GO:0071007 | U2-type catalytic step 2 spliceosome | "A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 2 | 2.537025e-02 | 7 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 6 | 2.947224e-07 | 7 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 7 | 0.000001 | 7 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 12 | 0.000012 | 7 |
| GO:MF | GO:0003730 | mRNA 3'-UTR binding | "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] | 4 | 0.000323 | 7 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 13 | 0.000572 | 7 |
| GO:MF | GO:0043021 | ribonucleoprotein complex binding | "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] | 4 | 0.001740 | 7 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 5 | 0.018124 | 7 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 5 | 0.020840 | 7 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 8 | 0.045062 | 7 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0048511 | rhythmic process | "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] | 6 | 0.000032 | 7 |
| GO:BP | GO:1903311 | regulation of mRNA metabolic process | "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 6 | 0.000036 | 7 |
| GO:BP | GO:0016071 | mRNA metabolic process | "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 10 | 0.000105 | 7 |
| GO:BP | GO:0000380 | alternative mRNA splicing, via spliceosome | "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] | 4 | 0.000153 | 7 |
| GO:BP | GO:0007623 | circadian rhythm | "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] | 5 | 0.000232 | 7 |
| GO:BP | GO:0000398 | mRNA splicing, via spliceosome | "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] | 9 | 0.000250 | 7 |
| GO:BP | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] | 9 | 0.000250 | 7 |
| GO:BP | GO:0000375 | RNA splicing, via transesterification reactions | "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] | 9 | 0.000256 | 7 |
| GO:BP | GO:0008380 | RNA splicing | "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] | 9 | 0.000511 | 7 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 14 | 0.000623 | 7 |
| GO:BP | GO:0006397 | mRNA processing | "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] | 9 | 0.000638 | 7 |
| GO:BP | GO:1903312 | negative regulation of mRNA metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 4 | 0.000662 | 7 |
| GO:BP | GO:0048024 | regulation of mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 4 | 0.000964 | 7 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 14 | 0.001717 | 7 |
| GO:BP | GO:0050684 | regulation of mRNA processing | "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] | 4 | 0.001977 | 7 |
| GO:BP | GO:0006396 | RNA processing | "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] | 10 | 0.006809 | 7 |
| GO:BP | GO:0043484 | regulation of RNA splicing | "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] | 4 | 0.007443 | 7 |
| GO:BP | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] | 3 | 0.007948 | 7 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 14 | 0.012795 | 7 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 14 | 0.023842 | 7 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 6 | 0.033340 | 7 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1181 | C complex spliceosome | C complex spliceosome | 5 | 0.000220 | 7 |
| CORUM | CORUM:351 | Spliceosome | Spliceosome | 5 | 0.003997 | 7 |
| CORUM | CORUM:1148 | snRNP-free U1A (SF-A) complex | snRNP-free U1A (SF-A) complex | 2 | 0.004192 | 7 |
| CORUM | CORUM:1183 | CDC5L complex | CDC5L complex | 3 | 0.008308 | 7 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 7 | 0.003773 | 7 |
| MIRNA | MIRNA:hsa-mir-548z | hsa-mir-548z | hsa-mir-548z | 9 | 0.004100 | 7 |
| MIRNA | MIRNA:hsa-mir-548ac | hsa-mir-548ac | hsa-mir-548ac | 9 | 0.004100 | 7 |
| MIRNA | MIRNA:hsa-mir-548d-3p | hsa-mir-548d-3p | hsa-mir-548d-3p | 9 | 0.004192 | 7 |
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 5 | 0.009032 | 7 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12277 | Factor: YY2; motif: NKCSGCCATTTTGN | Factor: YY2; motif: NKCSGCCATTTTGN | 4 | 0.004728 | 7 |
| TF | TF:M03990_1 | Factor: GABPA; motif: ACCGGAAGTN; match class: 1 | Factor: GABPA; motif: ACCGGAAGTN; match class: 1 | 7 | 0.022735 | 7 |
| TF | TF:M03925_1 | Factor: YY2; motif: NCCGCCATNTY; match class: 1 | Factor: YY2; motif: NCCGCCATNTY; match class: 1 | 6 | 0.023743 | 7 |
| TF | TF:M08875 | Factor: E2F; motif: NNTTTCGCGCN | Factor: E2F; motif: NNTTTCGCGCN | 13 | 0.031604 | 7 |
| TF | TF:M01597_1 | Factor: Zfp281; motif: TGGGGGAGGGG; match class: 1 | Factor: Zfp281; motif: TGGGGGAGGGG; match class: 1 | 3 | 0.037947 | 7 |
| TF | TF:M00940 | Factor: E2F-1; motif: NTTTCGCGCS | Factor: E2F-1; motif: NTTTCGCGCS | 14 | 0.043614 | 7 |
| TF | TF:M01816_1 | Factor: ZBP89; motif: YCCYCCCCCM; match class: 1 | Factor: ZBP89; motif: YCCYCCCCCM; match class: 1 | 4 | 0.047158 | 7 |
Community 8
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | Regulation of activated PAK-2p34 by proteasome mediated degradation | 10 | 2.839413e-20 | 8 |
| REAC | REAC:R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 10 | 4.371443e-20 | 8 |
| REAC | REAC:R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint | p53-Independent G1/S DNA damage checkpoint | 10 | 4.371443e-20 | 8 |
| REAC | REAC:R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 10 | 4.371443e-20 | 8 |
| REAC | REAC:R-HSA-69610 | p53-Independent DNA Damage Response | p53-Independent DNA Damage Response | 10 | 4.371443e-20 | 8 |
| REAC | REAC:R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | Ubiquitin-dependent degradation of Cyclin D | 10 | 4.371443e-20 | 8 |
| REAC | REAC:R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | Autodegradation of the E3 ubiquitin ligase COP1 | 10 | 4.371443e-20 | 8 |
| REAC | REAC:R-HSA-180534 | Vpu mediated degradation of CD4 | Vpu mediated degradation of CD4 | 10 | 4.371443e-20 | 8 |
| REAC | REAC:R-HSA-169911 | Regulation of Apoptosis | Regulation of Apoptosis | 10 | 5.387164e-20 | 8 |
| REAC | REAC:R-HSA-9604323 | Negative regulation of NOTCH4 signaling | Negative regulation of NOTCH4 signaling | 10 | 5.387164e-20 | 8 |
| REAC | REAC:R-HSA-180585 | Vif-mediated degradation of APOBEC3G | Vif-mediated degradation of APOBEC3G | 10 | 5.387164e-20 | 8 |
| REAC | REAC:R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | AUF1 (hnRNP D0) binds and destabilizes mRNA | 10 | 6.610422e-20 | 8 |
| REAC | REAC:R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | SCF-beta-TrCP mediated degradation of Emi1 | 10 | 8.078063e-20 | 8 |
| REAC | REAC:R-HSA-8941858 | Regulation of RUNX3 expression and activity | Regulation of RUNX3 expression and activity | 10 | 8.078063e-20 | 8 |
| REAC | REAC:R-HSA-4641257 | Degradation of AXIN | Degradation of AXIN | 10 | 8.078063e-20 | 8 |
| REAC | REAC:R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 10 | 8.078063e-20 | 8 |
| REAC | REAC:R-HSA-5362768 | Hh mutants are degraded by ERAD | Hh mutants are degraded by ERAD | 10 | 9.832531e-20 | 8 |
| REAC | REAC:R-HSA-69541 | Stabilization of p53 | Stabilization of p53 | 10 | 1.192258e-19 | 8 |
| REAC | REAC:R-HSA-4641258 | Degradation of DVL | Degradation of DVL | 10 | 1.192258e-19 | 8 |
| REAC | REAC:R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | NIK-->noncanonical NF-kB signaling | 10 | 1.734078e-19 | 8 |
| REAC | REAC:R-HSA-5387390 | Hh mutants abrogate ligand secretion | Hh mutants abrogate ligand secretion | 10 | 1.734078e-19 | 8 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 10 | 2.080548e-19 | 8 |
| REAC | REAC:R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | Dectin-1 mediated noncanonical NF-kB signaling | 10 | 2.080548e-19 | 8 |
| REAC | REAC:R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | GLI3 is processed to GLI3R by the proteasome | 10 | 2.080548e-19 | 8 |
| REAC | REAC:R-HSA-5610783 | Degradation of GLI2 by the proteasome | Degradation of GLI2 by the proteasome | 10 | 2.080548e-19 | 8 |
| REAC | REAC:R-HSA-5610780 | Degradation of GLI1 by the proteasome | Degradation of GLI1 by the proteasome | 10 | 2.080548e-19 | 8 |
| REAC | REAC:R-HSA-5678895 | Defective CFTR causes cystic fibrosis | Defective CFTR causes cystic fibrosis | 10 | 2.488086e-19 | 8 |
| REAC | REAC:R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | Autodegradation of Cdh1 by Cdh1:APC/C | 10 | 4.177228e-19 | 8 |
| REAC | REAC:R-HSA-4608870 | Asymmetric localization of PCP proteins | Asymmetric localization of PCP proteins | 10 | 4.177228e-19 | 8 |
| REAC | REAC:R-HSA-5358346 | Hedgehog ligand biogenesis | Hedgehog ligand biogenesis | 10 | 4.935904e-19 | 8 |
| REAC | REAC:R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 10 | 5.816349e-19 | 8 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 10 | 5.816349e-19 | 8 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 10 | 5.816349e-19 | 8 |
| REAC | REAC:R-HSA-1169091 | Activation of NF-kappaB in B cells | Activation of NF-kappaB in B cells | 10 | 6.835625e-19 | 8 |
| REAC | REAC:R-HSA-5658442 | Regulation of RAS by GAPs | Regulation of RAS by GAPs | 10 | 6.835625e-19 | 8 |
| REAC | REAC:R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | APC/C:Cdc20 mediated degradation of Securin | 10 | 8.012850e-19 | 8 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 10 | 8.012850e-19 | 8 |
| REAC | REAC:R-HSA-8948751 | Regulation of PTEN stability and activity | Regulation of PTEN stability and activity | 10 | 9.369403e-19 | 8 |
| REAC | REAC:R-HSA-8939902 | Regulation of RUNX2 expression and activity | Regulation of RUNX2 expression and activity | 10 | 1.271870e-18 | 8 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 10 | 1.271870e-18 | 8 |
| REAC | REAC:R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 10 | 1.710888e-18 | 8 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 10 | 1.710888e-18 | 8 |
| REAC | REAC:R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 10 | 1.977885e-18 | 8 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 10 | 1.977885e-18 | 8 |
| REAC | REAC:R-HSA-1234174 | Cellular response to hypoxia | Cellular response to hypoxia | 10 | 2.281796e-18 | 8 |
| REAC | REAC:R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | APC/C:Cdc20 mediated degradation of mitotic proteins | 10 | 2.627086e-18 | 8 |
| REAC | REAC:R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 10 | 3.018686e-18 | 8 |
| REAC | REAC:R-HSA-5619084 | ABC transporter disorders | ABC transporter disorders | 10 | 3.462035e-18 | 8 |
| REAC | REAC:R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | The role of GTSE1 in G2/M progression after G2 checkpoint | 10 | 3.963120e-18 | 8 |
| REAC | REAC:R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | Downstream signaling events of B Cell Receptor (BCR) | 10 | 4.528527e-18 | 8 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 10 | 5.165488e-18 | 8 |
| REAC | REAC:R-HSA-9013694 | Signaling by NOTCH4 | Signaling by NOTCH4 | 10 | 5.165488e-18 | 8 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 10 | 5.881938e-18 | 8 |
| REAC | REAC:R-HSA-195253 | Degradation of beta-catenin by the destruction complex | Degradation of beta-catenin by the destruction complex | 10 | 6.686570e-18 | 8 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 10 | 7.588898e-18 | 8 |
| REAC | REAC:R-HSA-446652 | Interleukin-1 family signaling | Interleukin-1 family signaling | 11 | 8.031907e-18 | 8 |
| REAC | REAC:R-HSA-5632684 | Hedgehog 'on' state | Hedgehog 'on' state | 10 | 8.599320e-18 | 8 |
| REAC | REAC:R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | Regulation of mRNA stability by proteins that bind AU-rich elements | 10 | 9.729190e-18 | 8 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 10 | 1.239792e-17 | 8 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 10 | 1.239792e-17 | 8 |
| REAC | REAC:R-HSA-5687128 | MAPK6/MAPK4 signaling | MAPK6/MAPK4 signaling | 10 | 1.396495e-17 | 8 |
| REAC | REAC:R-HSA-1236974 | ER-Phagosome pathway | ER-Phagosome pathway | 10 | 1.570795e-17 | 8 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 10 | 1.979271e-17 | 8 |
| REAC | REAC:R-HSA-4086400 | PCP/CE pathway | PCP/CE pathway | 10 | 1.979271e-17 | 8 |
| REAC | REAC:R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | Cross-presentation of soluble exogenous antigens (endosomes) | 9 | 2.074614e-17 | 8 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 10 | 2.772340e-17 | 8 |
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 10 | 2.772340e-17 | 8 |
| REAC | REAC:R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | Regulation of ornithine decarboxylase (ODC) | 9 | 3.070649e-17 | 8 |
| REAC | REAC:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | CLEC7A (Dectin-1) signaling | 10 | 3.449269e-17 | 8 |
| REAC | REAC:R-HSA-202424 | Downstream TCR signaling | Downstream TCR signaling | 10 | 3.840591e-17 | 8 |
| REAC | REAC:R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | TNFR2 non-canonical NF-kB pathway | 10 | 4.745217e-17 | 8 |
| REAC | REAC:R-HSA-5689603 | UCH proteinases | UCH proteinases | 10 | 5.837188e-17 | 8 |
| REAC | REAC:R-HSA-9824272 | Somitogenesis | Somitogenesis | 9 | 6.411303e-17 | 8 |
| REAC | REAC:R-HSA-382556 | ABC-family proteins mediated transport | ABC-family proteins mediated transport | 10 | 6.463765e-17 | 8 |
| REAC | REAC:R-HSA-1236975 | Antigen processing-Cross presentation | Antigen processing-Cross presentation | 10 | 7.901544e-17 | 8 |
| REAC | REAC:R-HSA-351202 | Metabolism of polyamines | Metabolism of polyamines | 9 | 1.072953e-16 | 8 |
| REAC | REAC:R-HSA-5610787 | Hedgehog 'off' state | Hedgehog 'off' state | 10 | 1.698328e-16 | 8 |
| REAC | REAC:R-HSA-9020702 | Interleukin-1 signaling | Interleukin-1 signaling | 10 | 1.698328e-16 | 8 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 10 | 2.663495e-16 | 8 |
| REAC | REAC:R-HSA-202403 | TCR signaling | TCR signaling | 10 | 3.171144e-16 | 8 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 10 | 3.456256e-16 | 8 |
| REAC | REAC:R-HSA-9755511 | KEAP1-NFE2L2 pathway | KEAP1-NFE2L2 pathway | 10 | 4.455267e-16 | 8 |
| REAC | REAC:R-HSA-9793380 | Formation of paraxial mesoderm | Formation of paraxial mesoderm | 9 | 5.694660e-16 | 8 |
| REAC | REAC:R-HSA-162909 | Host Interactions of HIV factors | Host Interactions of HIV factors | 10 | 5.706881e-16 | 8 |
| REAC | REAC:R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 10 | 6.708485e-16 | 8 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 10 | 7.865519e-16 | 8 |
| REAC | REAC:R-HSA-2871837 | FCERI mediated NF-kB activation | FCERI mediated NF-kB activation | 10 | 1.158245e-15 | 8 |
| REAC | REAC:R-HSA-5621481 | C-type lectin receptors (CLRs) | C-type lectin receptors (CLRs) | 10 | 1.158245e-15 | 8 |
| REAC | REAC:R-HSA-6807070 | PTEN Regulation | PTEN Regulation | 10 | 1.346608e-15 | 8 |
| REAC | REAC:R-HSA-68867 | Assembly of the pre-replicative complex | Assembly of the pre-replicative complex | 10 | 1.808102e-15 | 8 |
| REAC | REAC:R-HSA-3858494 | Beta-catenin independent WNT signaling | Beta-catenin independent WNT signaling | 10 | 1.943724e-15 | 8 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 10 | 2.769215e-15 | 8 |
| REAC | REAC:R-HSA-5358351 | Signaling by Hedgehog | Signaling by Hedgehog | 10 | 2.967943e-15 | 8 |
| REAC | REAC:R-HSA-69002 | DNA Replication Pre-Initiation | DNA Replication Pre-Initiation | 10 | 5.786855e-15 | 8 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 10 | 7.010896e-15 | 8 |
| REAC | REAC:R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | Signaling by the B Cell Receptor (BCR) | 10 | 7.467874e-15 | 8 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 10 | 9.575945e-15 | 8 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 10 | 1.220482e-14 | 8 |
| REAC | REAC:R-HSA-5619115 | Disorders of transmembrane transporters | Disorders of transmembrane transporters | 10 | 1.374858e-14 | 8 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 10 | 1.639470e-14 | 8 |
| REAC | REAC:R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | Fc epsilon receptor (FCERI) signaling | 10 | 2.310199e-14 | 8 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 10 | 3.047620e-14 | 8 |
| REAC | REAC:R-HSA-2467813 | Separation of Sister Chromatids | Separation of Sister Chromatids | 10 | 3.218295e-14 | 8 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 10 | 4.925078e-14 | 8 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 10 | 5.462597e-14 | 8 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 10 | 9.027130e-14 | 8 |
| REAC | REAC:R-HSA-9711123 | Cellular response to chemical stress | Cellular response to chemical stress | 10 | 9.951445e-14 | 8 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 10 | 1.389548e-13 | 8 |
| REAC | REAC:R-HSA-9758941 | Gastrulation | Gastrulation | 9 | 1.515300e-13 | 8 |
| REAC | REAC:R-HSA-5689880 | Ub-specific processing proteases | Ub-specific processing proteases | 10 | 1.673344e-13 | 8 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 10 | 2.100850e-13 | 8 |
| REAC | REAC:R-HSA-68882 | Mitotic Anaphase | Mitotic Anaphase | 10 | 2.297700e-13 | 8 |
| REAC | REAC:R-HSA-2555396 | Mitotic Metaphase and Anaphase | Mitotic Metaphase and Anaphase | 10 | 2.402213e-13 | 8 |
| REAC | REAC:R-HSA-201681 | TCF dependent signaling in response to WNT | TCF dependent signaling in response to WNT | 10 | 2.624159e-13 | 8 |
| REAC | REAC:R-HSA-157118 | Signaling by NOTCH | Signaling by NOTCH | 10 | 2.624159e-13 | 8 |
| REAC | REAC:R-HSA-8878171 | Transcriptional regulation by RUNX1 | Transcriptional regulation by RUNX1 | 10 | 2.991745e-13 | 8 |
| REAC | REAC:R-HSA-8951664 | Neddylation | Neddylation | 10 | 4.575607e-13 | 8 |
| REAC | REAC:R-HSA-1257604 | PIP3 activates AKT signaling | PIP3 activates AKT signaling | 10 | 6.347159e-13 | 8 |
| REAC | REAC:R-HSA-5673001 | RAF/MAP kinase cascade | RAF/MAP kinase cascade | 10 | 1.097863e-12 | 8 |
| REAC | REAC:R-HSA-5684996 | MAPK1/MAPK3 signaling | MAPK1/MAPK3 signaling | 10 | 1.325703e-12 | 8 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 10 | 2.541005e-12 | 8 |
| REAC | REAC:R-HSA-9006925 | Intracellular signaling by second messengers | Intracellular signaling by second messengers | 10 | 2.820625e-12 | 8 |
| REAC | REAC:R-HSA-449147 | Signaling by Interleukins | Signaling by Interleukins | 11 | 3.083938e-12 | 8 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 10 | 3.464300e-12 | 8 |
| REAC | REAC:R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | Antigen processing: Ubiquitination & Proteasome degradation | 10 | 4.835027e-12 | 8 |
| REAC | REAC:R-HSA-5683057 | MAPK family signaling cascades | MAPK family signaling cascades | 10 | 5.161541e-12 | 8 |
| REAC | REAC:R-HSA-195721 | Signaling by WNT | Signaling by WNT | 10 | 8.845684e-12 | 8 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 10 | 2.533377e-11 | 8 |
| REAC | REAC:R-HSA-983169 | Class I MHC mediated antigen processing & presentation | Class I MHC mediated antigen processing & presentation | 10 | 4.014780e-11 | 8 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 10 | 8.002678e-11 | 8 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 10 | 1.916160e-10 | 8 |
| REAC | REAC:R-HSA-382551 | Transport of small molecules | Transport of small molecules | 11 | 3.415262e-10 | 8 |
| REAC | REAC:R-HSA-1280215 | Cytokine Signaling in Immune system | Cytokine Signaling in Immune system | 11 | 7.188782e-10 | 8 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 10 | 1.436570e-09 | 8 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 10 | 1.603242e-09 | 8 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 10 | 2.251825e-09 | 8 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 11 | 2.479979e-09 | 8 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 10 | 1.333635e-08 | 8 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 10 | 2.078893e-08 | 8 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 11 | 2.128768e-08 | 8 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 10 | 6.468459e-08 | 8 |
| REAC | REAC:R-HSA-1280218 | Adaptive Immune System | Adaptive Immune System | 10 | 7.689048e-08 | 8 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 10 | 7.689048e-08 | 8 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 10 | 1.580427e-06 | 8 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 10 | 4.889970e-06 | 8 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 11 | 8.688726e-06 | 8 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 10 | 1.222519e-05 | 8 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 10 | 1.503776e-05 | 8 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 10 | 2.386228e-05 | 8 |
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 11 | 3.306622e-05 | 8 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 10 | 3.705775e-05 | 8 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 11 | 2.999351e-04 | 8 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 10 | 7.256934e-04 | 8 |
| REAC | REAC:R-HSA-1430728 | Metabolism | Metabolism | 10 | 8.568368e-04 | 8 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000502 | proteasome complex | "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome] | 9 | 2.946912e-19 | 8 |
| GO:CC | GO:1905369 | endopeptidase complex | "A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 9 | 1.433321e-17 | 8 |
| GO:CC | GO:1905368 | peptidase complex | "A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 9 | 1.505757e-16 | 8 |
| GO:CC | GO:0005838 | proteasome regulatory particle | "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 6 | 4.667642e-14 | 8 |
| GO:CC | GO:0022624 | proteasome accessory complex | "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu] | 6 | 1.107130e-13 | 8 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 9 | 9.943318e-09 | 8 |
| GO:CC | GO:0008541 | proteasome regulatory particle, lid subcomplex | "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb] | 3 | 7.565195e-07 | 8 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 9 | 2.674447e-06 | 8 |
| GO:CC | GO:0008540 | proteasome regulatory particle, base subcomplex | "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 3 | 2.968419e-06 | 8 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 11 | 8.034451e-06 | 8 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 9 | 1.197788e-05 | 8 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 9 | 1.354893e-05 | 8 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 9 | 1.360429e-05 | 8 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 9 | 1.360429e-05 | 8 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 11 | 1.433620e-05 | 8 |
| GO:CC | GO:0005839 | proteasome core complex | "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] | 3 | 2.381576e-05 | 8 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 4 | 4.982133e-05 | 8 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 4 | 2.412135e-04 | 8 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 11 | 2.423419e-04 | 8 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 11 | 2.451715e-04 | 8 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 10 | 3.425567e-04 | 8 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 9 | 5.937102e-04 | 8 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 8 | 1.116150e-03 | 8 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 8 | 1.136098e-03 | 8 |
| GO:CC | GO:0019773 | proteasome core complex, alpha-subunit complex | "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779] | 2 | 1.345165e-03 | 8 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 11 | 1.849503e-03 | 8 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 11 | 1.849503e-03 | 8 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 11 | 1.849503e-03 | 8 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 4 | 2.231188e-03 | 8 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 4 | 2.369805e-03 | 8 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 4 | 2.398273e-03 | 8 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 11 | 1.146737e-02 | 8 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03050 | Proteasome | Proteasome | 9 | 2.254833e-17 | 8 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | Spinocerebellar ataxia | 9 | 9.285601e-13 | 8 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 10 | 2.748622e-12 | 8 |
| KEGG | KEGG:05020 | Prion disease | Prion disease | 9 | 3.614703e-10 | 8 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 10 | 9.491289e-10 | 8 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 9 | 1.051389e-09 | 8 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis | 9 | 5.037921e-09 | 8 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 9 | 7.963519e-09 | 8 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 6 | 7.246512e-06 | 8 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:193 | PA700-20S-PA28 complex | PA700-20S-PA28 complex | 9 | 4.308855e-16 | 8 |
| CORUM | CORUM:32 | PA700 complex | PA700 complex | 6 | 6.888557e-10 | 8 |
| CORUM | CORUM:181 | 26S proteasome | 26S proteasome | 5 | 1.391906e-07 | 8 |
| CORUM | CORUM:191 | 20S proteasome | 20S proteasome | 3 | 5.397046e-04 | 8 |
| CORUM | CORUM:194 | PA28gamma-20S proteasome | PA28gamma-20S proteasome | 3 | 7.184872e-04 | 8 |
| CORUM | CORUM:192 | PA28-20S proteasome | PA28-20S proteasome | 3 | 9.325808e-04 | 8 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP183 | Proteasome degradation | Proteasome degradation | 9 | 7.156226e-16 | 8 |
| WP | WP:WP2359 | Parkin ubiquitin proteasomal system pathway | Parkin ubiquitin proteasomal system pathway | 6 | 2.754551e-08 | 8 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 8 | 3.282663e-08 | 8 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 8 | 3.822967e-08 | 8 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 10 | 4.946684e-11 | 8 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 10 | 5.348902e-11 | 8 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 9 | 1.092566e-10 | 8 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 10 | 3.984920e-10 | 8 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 9 | 1.260035e-09 | 8 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 9 | 4.654749e-09 | 8 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 10 | 5.901515e-09 | 8 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 10 | 1.400103e-07 | 8 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 10 | 2.241453e-07 | 8 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 10 | 6.353135e-05 | 8 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 11 | 8.857932e-04 | 8 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0036402 | proteasome-activating activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome." [GOC:rb, PMID:11430818] | 2 | 0.001077 | 8 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 11 | 0.014332 | 8 |
| HPA | HPA:0291162 | Liver; cholangiocytes[≥Medium] | Liver; cholangiocytes[≥Medium] | 8 | 0.034297 | 8 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 11 | 0.043537 | 8 |
Community 9
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471381 | Skin 2; arrector pili muscle cells[≥Low] | Skin 2; arrector pili muscle cells[≥Low] | 2 | 0.03879 | 9 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 6 | 0.044795 | 9 |
Community 10
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5199 | Kinase maturation complex 1 | Kinase maturation complex 1 | 8 | 2.431780e-16 | 10 |
| CORUM | CORUM:2112 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex | 3 | 1.322697e-05 | 10 |
| CORUM | CORUM:5234 | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex | 3 | 3.301605e-05 | 10 |
| CORUM | CORUM:5269 | TNF-alpha/NF-kappa B signaling complex 8 | TNF-alpha/NF-kappa B signaling complex 8 | 3 | 6.592951e-05 | 10 |
| CORUM | CORUM:5212 | Kinase maturation complex 2 | Kinase maturation complex 2 | 3 | 1.840293e-04 | 10 |
| CORUM | CORUM:5268 | TNF-alpha/NF-kappa B signaling complex 7 | TNF-alpha/NF-kappa B signaling complex 7 | 3 | 1.840293e-04 | 10 |
| CORUM | CORUM:5286 | TNF-alpha/NF-kappa B signaling complex 10 | TNF-alpha/NF-kappa B signaling complex 10 | 3 | 3.931236e-04 | 10 |
| CORUM | CORUM:5266 | TNF-alpha/NF-kappa B signaling complex 6 | TNF-alpha/NF-kappa B signaling complex 6 | 3 | 9.325808e-04 | 10 |
| CORUM | CORUM:5849 | HSP90-CDC37-LRRK2 complex | HSP90-CDC37-LRRK2 complex | 2 | 4.192434e-03 | 10 |
| CORUM | CORUM:6512 | ILK-HSP90-CDC37 complex | ILK-HSP90-CDC37 complex | 2 | 4.192434e-03 | 10 |
| CORUM | CORUM:5285 | TNF-alpha/NF-kappa B signaling complex 9 | TNF-alpha/NF-kappa B signaling complex 9 | 2 | 1.393072e-02 | 10 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 5 | 2.275858e-10 | 10 |
| REAC | REAC:R-HSA-5625740 | RHO GTPases activate PKNs | RHO GTPases activate PKNs | 6 | 8.270356e-08 | 10 |
| REAC | REAC:R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 4 | 1.203083e-07 | 10 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 7 | 1.716714e-07 | 10 |
| REAC | REAC:R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 4 | 3.311803e-07 | 10 |
| REAC | REAC:R-HSA-111447 | Activation of BAD and translocation to mitochondria | Activation of BAD and translocation to mitochondria | 4 | 3.311803e-07 | 10 |
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 9 | 9.159818e-07 | 10 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 9 | 1.105142e-06 | 10 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 4 | 6.591236e-06 | 10 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 6 | 7.532782e-06 | 10 |
| REAC | REAC:R-HSA-9705683 | SARS-CoV-2-host interactions | SARS-CoV-2-host interactions | 6 | 7.765732e-06 | 10 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 6 | 8.004616e-06 | 10 |
| REAC | REAC:R-HSA-69473 | G2/M DNA damage checkpoint | G2/M DNA damage checkpoint | 5 | 9.297153e-06 | 10 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 8 | 2.411940e-05 | 10 |
| REAC | REAC:R-HSA-3371511 | HSF1 activation | HSF1 activation | 3 | 6.530191e-05 | 10 |
| REAC | REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | Intrinsic Pathway for Apoptosis | 4 | 7.500516e-05 | 10 |
| REAC | REAC:R-HSA-9694516 | SARS-CoV-2 Infection | SARS-CoV-2 Infection | 6 | 8.072141e-05 | 10 |
| REAC | REAC:R-HSA-195258 | RHO GTPase Effectors | RHO GTPase Effectors | 6 | 1.335695e-04 | 10 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 5 | 1.659802e-04 | 10 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 5 | 2.154248e-04 | 10 |
| REAC | REAC:R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4 | 2.414475e-04 | 10 |
| REAC | REAC:R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | Assembly and release of respiratory syncytial virus (RSV) virions | 2 | 3.283781e-04 | 10 |
| REAC | REAC:R-HSA-9834752 | Respiratory syncytial virus genome replication | Respiratory syncytial virus genome replication | 2 | 3.283781e-04 | 10 |
| REAC | REAC:R-HSA-5628897 | TP53 Regulates Metabolic Genes | TP53 Regulates Metabolic Genes | 4 | 4.496726e-04 | 10 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 4 | 4.716030e-04 | 10 |
| REAC | REAC:R-HSA-3371556 | Cellular response to heat stress | Cellular response to heat stress | 4 | 5.178389e-04 | 10 |
| REAC | REAC:R-HSA-9013418 | RHOBTB2 GTPase cycle | RHOBTB2 GTPase cycle | 3 | 5.221417e-04 | 10 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 4 | 7.371739e-04 | 10 |
| REAC | REAC:R-HSA-9679506 | SARS-CoV Infections | SARS-CoV Infections | 6 | 1.145390e-03 | 10 |
| REAC | REAC:R-HSA-9706574 | RHOBTB GTPase Cycle | RHOBTB GTPase Cycle | 3 | 1.915482e-03 | 10 |
| REAC | REAC:R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | Drug resistance in ERBB2 KD mutants | 2 | 1.967881e-03 | 10 |
| REAC | REAC:R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | Drug-mediated inhibition of ERBB2 signaling | 2 | 1.967881e-03 | 10 |
| REAC | REAC:R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | Resistance of ERBB2 KD mutants to AEE788 | 2 | 1.967881e-03 | 10 |
| REAC | REAC:R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | Resistance of ERBB2 KD mutants to trastuzumab | 2 | 1.967881e-03 | 10 |
| REAC | REAC:R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | Resistance of ERBB2 KD mutants to tesevatinib | 2 | 1.967881e-03 | 10 |
| REAC | REAC:R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | Resistance of ERBB2 KD mutants to sapitinib | 2 | 1.967881e-03 | 10 |
| REAC | REAC:R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | Drug resistance in ERBB2 TMD/JMD mutants | 2 | 1.967881e-03 | 10 |
| REAC | REAC:R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | Resistance of ERBB2 KD mutants to neratinib | 2 | 1.967881e-03 | 10 |
| REAC | REAC:R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | Resistance of ERBB2 KD mutants to lapatinib | 2 | 1.967881e-03 | 10 |
| REAC | REAC:R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | Resistance of ERBB2 KD mutants to afatinib | 2 | 1.967881e-03 | 10 |
| REAC | REAC:R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | Resistance of ERBB2 KD mutants to osimertinib | 2 | 1.967881e-03 | 10 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 5 | 2.475119e-03 | 10 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 6 | 3.227901e-03 | 10 |
| REAC | REAC:R-HSA-9678108 | SARS-CoV-1 Infection | SARS-CoV-1 Infection | 4 | 3.457404e-03 | 10 |
| REAC | REAC:R-HSA-5336415 | Uptake and function of diphtheria toxin | Uptake and function of diphtheria toxin | 2 | 4.913743e-03 | 10 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 10 | 5.633422e-03 | 10 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 5 | 7.097144e-03 | 10 |
| REAC | REAC:R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | Constitutive Signaling by Overexpressed ERBB2 | 2 | 1.177156e-02 | 10 |
| REAC | REAC:R-HSA-380259 | Loss of Nlp from mitotic centrosomes | Loss of Nlp from mitotic centrosomes | 3 | 1.437260e-02 | 10 |
| REAC | REAC:R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome | Loss of proteins required for interphase microtubule organization from the centrosome | 3 | 1.437260e-02 | 10 |
| REAC | REAC:R-HSA-8854518 | AURKA Activation by TPX2 | AURKA Activation by TPX2 | 3 | 1.636107e-02 | 10 |
| REAC | REAC:R-HSA-9614399 | Regulation of localization of FOXO transcription factors | Regulation of localization of FOXO transcription factors | 2 | 2.154199e-02 | 10 |
| REAC | REAC:R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | Recruitment of mitotic centrosome proteins and complexes | 3 | 2.338910e-02 | 10 |
| REAC | REAC:R-HSA-380287 | Centrosome maturation | Centrosome maturation | 3 | 2.338910e-02 | 10 |
| REAC | REAC:R-HSA-5637812 | Signaling by EGFRvIII in Cancer | Signaling by EGFRvIII in Cancer | 2 | 2.544329e-02 | 10 |
| REAC | REAC:R-HSA-5637810 | Constitutive Signaling by EGFRvIII | Constitutive Signaling by EGFRvIII | 2 | 2.544329e-02 | 10 |
| REAC | REAC:R-HSA-3371568 | Attenuation phase | Attenuation phase | 2 | 2.966585e-02 | 10 |
| REAC | REAC:R-HSA-9665348 | Signaling by ERBB2 ECD mutants | Signaling by ERBB2 ECD mutants | 2 | 2.966585e-02 | 10 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 3 | 3.783196e-02 | 10 |
| REAC | REAC:R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translation | Respiratory syncytial virus (RSV) genome replication, transcription and translation | 2 | 3.907241e-02 | 10 |
| REAC | REAC:R-HSA-399954 | Sema3A PAK dependent Axon repulsion | Sema3A PAK dependent Axon repulsion | 2 | 3.907241e-02 | 10 |
| REAC | REAC:R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | Anchoring of the basal body to the plasma membrane | 3 | 4.027618e-02 | 10 |
| REAC | REAC:R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2 | 4.425524e-02 | 10 |
| REAC | REAC:R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2 | 4.425524e-02 | 10 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 6 | 4.495874e-02 | 10 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 8 | 4.806230e-02 | 10 |
| REAC | REAC:R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | Signaling by ERBB2 TMD/JMD mutants | 2 | 4.975698e-02 | 10 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 8 | 1.133578e-07 | 10 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 10 | 1.767220e-06 | 10 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 7 | 1.027455e-05 | 10 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 7 | 2.104463e-05 | 10 |
| GO:MF | GO:0023026 | MHC class II protein complex binding | "Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw] | 3 | 7.136922e-05 | 10 |
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 3 | 1.581306e-04 | 10 |
| GO:MF | GO:0023023 | MHC protein complex binding | "Binding to a major histocompatibility complex." [GOC:mtg_signal, GOC:vw] | 3 | 1.918097e-04 | 10 |
| GO:MF | GO:0044325 | transmembrane transporter binding | "Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372] | 4 | 2.523156e-04 | 10 |
| GO:MF | GO:0098772 | molecular function regulator activity | "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt] | 8 | 1.393375e-03 | 10 |
| GO:MF | GO:0030911 | TPR domain binding | "Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah] | 2 | 1.507103e-03 | 10 |
| GO:MF | GO:0030235 | nitric-oxide synthase regulator activity | "Binds to and modulates the activity of nitric oxide synthase." [GOC:mah] | 2 | 1.507103e-03 | 10 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 3 | 1.741403e-03 | 10 |
| GO:MF | GO:0097110 | scaffold protein binding | "Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes." [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein] | 3 | 1.900805e-03 | 10 |
| GO:MF | GO:0004517 | nitric-oxide synthase activity | "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, RHEA:19897] | 2 | 3.226317e-03 | 10 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 3 | 8.014262e-03 | 10 |
| GO:MF | GO:0005159 | insulin-like growth factor receptor binding | "Binding to an insulin-like growth factor receptor." [GOC:jl] | 2 | 8.586528e-03 | 10 |
| GO:MF | GO:0042826 | histone deacetylase binding | "Binding to histone deacetylase." [GOC:jl] | 3 | 1.135786e-02 | 10 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 5 | 1.225924e-02 | 10 |
| GO:MF | GO:0070182 | DNA polymerase binding | "Binding to a DNA polymerase." [GOC:BHF, GOC:mah] | 2 | 1.357744e-02 | 10 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 7 | 1.809762e-02 | 10 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 5 | 2.411388e-02 | 10 |
| GO:MF | GO:0097718 | disordered domain specific binding | "Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698] | 2 | 2.892697e-02 | 10 |
| GO:MF | GO:0140311 | protein sequestering activity | "Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:1493333] | 2 | 3.098298e-02 | 10 |
| GO:MF | GO:0071889 | 14-3-3 protein binding | "Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, PMID:15167810, PMID:19575580] | 2 | 3.756979e-02 | 10 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 5 | 3.845246e-02 | 10 |
| GO:MF | GO:0140678 | molecular function inhibitor activity | "A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators] | 4 | 4.277592e-02 | 10 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5376 | 17p13 3 YWHAE copy number variation | 17p13 3 YWHAE copy number variation | 4 | 0.000002 | 10 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 5 | 0.000044 | 10 |
| WP | WP:WP536 | Calcium regulation in cardiac cells | Calcium regulation in cardiac cells | 4 | 0.004969 | 10 |
| WP | WP:WP289 | Myometrial relaxation and contraction pathways | Myometrial relaxation and contraction pathways | 4 | 0.005511 | 10 |
| WP | WP:WP706 | Sudden infant death syndrome SIDS susceptibility pathways | Sudden infant death syndrome SIDS susceptibility pathways | 4 | 0.006247 | 10 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 12 | 0.000007 | 10 |
| GO:CC | GO:1990565 | HSP90-CDC37 chaperone complex | "A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins." [GOC:bhm, GOC:pad, GOC:PARL, PMID:21855797, PMID:22939624] | 2 | 0.000030 | 10 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 8 | 0.000261 | 10 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 8 | 0.000290 | 10 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 8 | 0.000291 | 10 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 8 | 0.000291 | 10 |
| GO:CC | GO:0044294 | dendritic growth cone | "The migrating motile tip of a growing nerve cell dendrite." [GOC:jl] | 2 | 0.001076 | 10 |
| GO:CC | GO:0044292 | dendrite terminus | "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole." [GOC:jl, NIF_Subcellular:sao28175134] | 2 | 0.002717 | 10 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 3 | 0.003145 | 10 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 3 | 0.003145 | 10 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 4 | 0.006581 | 10 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 4 | 0.007202 | 10 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 8 | 0.007808 | 10 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 5 | 0.008106 | 10 |
| GO:CC | GO:0044295 | axonal growth cone | "The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954] | 2 | 0.012925 | 10 |
| GO:CC | GO:0101031 | protein folding chaperone complex | "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] | 2 | 0.024284 | 10 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 8 | 0.032816 | 10 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 8 | 0.048554 | 10 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 7 | 0.000008 | 10 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 5 | 0.000035 | 10 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 5 | 0.000085 | 10 |
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 5 | 0.000085 | 10 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 4 | 0.003001 | 10 |
| KEGG | KEGG:04612 | Antigen processing and presentation | Antigen processing and presentation | 3 | 0.006323 | 10 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 4 | 0.007670 | 10 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | Progesterone-mediated oocyte maturation | 3 | 0.020181 | 10 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006605 | protein targeting | "The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] | 6 | 0.000278 | 10 |
| GO:BP | GO:0051131 | chaperone-mediated protein complex assembly | "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai] | 3 | 0.000366 | 10 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 10 | 0.001522 | 10 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 9 | 0.002287 | 10 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 9 | 0.002373 | 10 |
| GO:BP | GO:0021762 | substantia nigra development | "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420] | 3 | 0.002911 | 10 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 8 | 0.003299 | 10 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 7 | 0.006722 | 10 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 4 | 0.006806 | 10 |
| GO:BP | GO:0034605 | cellular response to heat | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] | 3 | 0.007797 | 10 |
| GO:BP | GO:1905323 | telomerase holoenzyme complex assembly | "The aggregation, arrangement and bonding together of a set of components to form a telomerase holoenzyme complex." [GO_REF:0000079, GOC:TermGenie, PMID:26305931] | 2 | 0.008026 | 10 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 9 | 0.008490 | 10 |
| GO:BP | GO:0048857 | neural nucleus development | "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021] | 3 | 0.009755 | 10 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 6 | 0.011364 | 10 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 6 | 0.013893 | 10 |
| GO:BP | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] | 3 | 0.014594 | 10 |
| GO:BP | GO:0030901 | midbrain development | "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [PMID:4975589, PMID:4992177] | 3 | 0.022955 | 10 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 7 | 0.028048 | 10 |
| GO:BP | GO:0009408 | response to heat | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] | 3 | 0.029403 | 10 |
| GO:BP | GO:0006468 | protein phosphorylation | "The process of introducing a phosphate group on to a protein." [GOC:hb] | 6 | 0.034071 | 10 |
| GO:BP | GO:0007008 | outer mitochondrial membrane organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 2 | 0.034704 | 10 |
| GO:BP | GO:0045040 | protein insertion into mitochondrial outer membrane | "The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes." [GOC:mcc, GOC:vw, PMID:18672008] | 2 | 0.034704 | 10 |
| GO:BP | GO:0045184 | establishment of protein localization | "The directed movement of a protein to a specific location." [GOC:bf] | 7 | 0.037291 | 10 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 8 | 0.042572 | 10 |
| GO:BP | GO:0046822 | regulation of nucleocytoplasmic transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] | 3 | 0.044505 | 10 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-141-3p | hsa-mir-141-3p | hsa-mir-141-3p | 4 | 0.001139 | 10 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M08878 | Factor: EGR; motif: CGCCCCCGCNN | Factor: EGR; motif: CGCCCCCGCNN | 12 | 0.017111 | 10 |
Community 11
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-68962 | Activation of the pre-replicative complex | Activation of the pre-replicative complex | 10 | 4.336647e-23 | 11 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 11 | 1.354602e-19 | 11 |
| REAC | REAC:R-HSA-176187 | Activation of ATR in response to replication stress | Activation of ATR in response to replication stress | 9 | 3.195639e-19 | 11 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 11 | 5.454676e-19 | 11 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 11 | 7.750060e-18 | 11 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 10 | 5.884689e-17 | 11 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 9 | 1.902402e-16 | 11 |
| REAC | REAC:R-HSA-69002 | DNA Replication Pre-Initiation | DNA Replication Pre-Initiation | 10 | 9.884156e-16 | 11 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 10 | 1.197787e-15 | 11 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 9 | 2.211535e-15 | 11 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 10 | 4.387874e-13 | 11 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 9 | 5.621422e-13 | 11 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 11 | 1.320530e-12 | 11 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 11 | 1.394593e-11 | 11 |
| REAC | REAC:R-HSA-68867 | Assembly of the pre-replicative complex | Assembly of the pre-replicative complex | 8 | 3.070747e-11 | 11 |
| REAC | REAC:R-HSA-176974 | Unwinding of DNA | Unwinding of DNA | 5 | 8.278160e-11 | 11 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 5 | 8.380672e-09 | 11 |
| REAC | REAC:R-HSA-69190 | DNA strand elongation | DNA strand elongation | 5 | 2.085752e-08 | 11 |
| REAC | REAC:R-HSA-68689 | CDC6 association with the ORC:origin complex | CDC6 association with the ORC:origin complex | 3 | 1.265410e-05 | 11 |
| REAC | REAC:R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | E2F-enabled inhibition of pre-replication complex formation | 2 | 9.933477e-03 | 11 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP466 | DNA replication | DNA replication | 10 | 2.944036e-21 | 11 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 10 | 2.303371e-16 | 11 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 8 | 1.112899e-13 | 11 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 7 | 3.728133e-10 | 11 |
| WP | WP:WP4352 | Ciliary landscape | Ciliary landscape | 4 | 1.346413e-02 | 11 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006270 | DNA replication initiation | "The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641] | 9 | 3.861539e-21 | 11 |
| GO:BP | GO:0006261 | DNA-templated DNA replication | "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] | 10 | 6.689620e-18 | 11 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 10 | 2.262182e-15 | 11 |
| GO:BP | GO:0000727 | double-strand break repair via break-induced replication | "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855] | 5 | 1.334008e-11 | 11 |
| GO:BP | GO:0090329 | regulation of DNA-templated DNA replication | "Any process that modulates the rate, frequency, or extent of DNA-templated DNA replication, the process in which new strands of DNA are synthesized." [GOC:dph, GOC:tb] | 6 | 1.835649e-11 | 11 |
| GO:BP | GO:0033260 | nuclear DNA replication | "The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] | 6 | 2.149892e-11 | 11 |
| GO:BP | GO:0044786 | cell cycle DNA replication | "The DNA-dependent DNA replication that takes place as part of the cell cycle." [GOC:mtg_cell_cycle] | 6 | 3.891280e-11 | 11 |
| GO:BP | GO:0030174 | regulation of DNA-templated DNA replication initiation | "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah] | 5 | 5.054504e-11 | 11 |
| GO:BP | GO:0006275 | regulation of DNA replication | "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] | 7 | 6.686936e-11 | 11 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 10 | 7.847154e-10 | 11 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 9 | 5.416694e-09 | 11 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 9 | 2.725413e-08 | 11 |
| GO:BP | GO:1902969 | mitotic DNA replication | "Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] | 4 | 1.201725e-07 | 11 |
| GO:BP | GO:0000076 | DNA replication checkpoint signaling | "A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518] | 4 | 2.444413e-07 | 11 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 9 | 6.874763e-07 | 11 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 7 | 1.566837e-06 | 11 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 9 | 7.047501e-06 | 11 |
| GO:BP | GO:0000724 | double-strand break repair via homologous recombination | "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] | 5 | 2.995797e-05 | 11 |
| GO:BP | GO:0000725 | recombinational repair | "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] | 5 | 3.416630e-05 | 11 |
| GO:BP | GO:0006271 | DNA strand elongation involved in DNA replication | "The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication." [GOC:mah, ISBN:071673706X, ISBN:0815316194] | 3 | 6.037551e-05 | 11 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 6 | 1.322700e-04 | 11 |
| GO:BP | GO:0006302 | double-strand break repair | "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] | 5 | 4.174808e-04 | 11 |
| GO:BP | GO:0031570 | DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] | 4 | 4.456158e-04 | 11 |
| GO:BP | GO:0006310 | DNA recombination | "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] | 5 | 6.331605e-04 | 11 |
| GO:BP | GO:0071163 | DNA replication preinitiation complex assembly | "The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins as part of initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity." [GOC:mah, PMID:28209641] | 2 | 9.328404e-04 | 11 |
| GO:BP | GO:0022616 | DNA strand elongation | "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:isa_complete, GOC:mah] | 3 | 1.024571e-03 | 11 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 5 | 1.761960e-03 | 11 |
| GO:BP | GO:0000075 | cell cycle checkpoint signaling | "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] | 4 | 2.280535e-03 | 11 |
| GO:BP | GO:1902975 | mitotic DNA replication initiation | "Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] | 2 | 3.107693e-03 | 11 |
| GO:BP | GO:1902315 | nuclear cell cycle DNA replication initiation | "Any DNA replication initiation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] | 2 | 3.107693e-03 | 11 |
| GO:BP | GO:1902292 | cell cycle DNA replication initiation | "Any DNA replication initiation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] | 2 | 3.107693e-03 | 11 |
| GO:BP | GO:1901988 | negative regulation of cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 7.301983e-03 | 11 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 5 | 1.101821e-02 | 11 |
| GO:BP | GO:0010948 | negative regulation of cell cycle process | "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 4 | 1.336440e-02 | 11 |
| GO:BP | GO:0033314 | mitotic DNA replication checkpoint signaling | "A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle] | 2 | 1.706307e-02 | 11 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 5 | 2.258492e-02 | 11 |
| GO:BP | GO:2000105 | positive regulation of DNA-templated DNA replication | "Any process that activates or increases the frequency, rate or extent of DNA-templated DNA replication." [GOC:mah] | 2 | 2.820746e-02 | 11 |
| GO:BP | GO:0033262 | regulation of nuclear cell cycle DNA replication | "Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] | 2 | 2.820746e-02 | 11 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 3.798092e-02 | 11 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 11 | 3.588944e-18 | 11 |
| KEGG | KEGG:03030 | DNA replication | DNA replication | 4 | 5.165393e-06 | 11 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0071162 | CMG complex | "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417] | 5 | 5.162015e-13 | 11 |
| GO:CC | GO:0031261 | DNA replication preinitiation complex | "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184] | 5 | 1.437340e-12 | 11 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 7 | 4.737469e-10 | 11 |
| GO:CC | GO:0042555 | MCM complex | "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] | 4 | 1.165973e-09 | 11 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 6 | 9.330026e-09 | 11 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 7 | 2.125572e-08 | 11 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 11 | 1.399514e-06 | 11 |
| GO:CC | GO:0032993 | protein-DNA complex | "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] | 5 | 7.035112e-06 | 11 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 11 | 2.558547e-05 | 11 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 8 | 6.054443e-05 | 11 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 11 | 2.057724e-04 | 11 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 11 | 2.057724e-04 | 11 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 11 | 2.057724e-04 | 11 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 8 | 5.716907e-04 | 11 |
| GO:CC | GO:0000808 | origin recognition complex | "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] | 2 | 6.740205e-04 | 11 |
| GO:CC | GO:0005664 | nuclear origin of replication recognition complex | "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] | 2 | 6.740205e-04 | 11 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 10 | 5.238406e-03 | 11 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 10 | 5.245975e-03 | 11 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 11 | 1.855441e-02 | 11 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 4 | 3.748603e-02 | 11 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 5 | 4.061453e-02 | 11 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0017116 | single-stranded DNA helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl] | 4 | 8.273667e-08 | 11 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 5 | 6.540830e-07 | 11 |
| GO:MF | GO:0003678 | DNA helicase activity | "Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl] | 4 | 4.210275e-06 | 11 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 6 | 5.699174e-06 | 11 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 6 | 6.878883e-05 | 11 |
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 4 | 8.523319e-05 | 11 |
| GO:MF | GO:0004386 | helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] | 4 | 2.306706e-04 | 11 |
| GO:MF | GO:0120545 | nucleic acid conformation isomerase activity | "Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-] | 4 | 2.942572e-04 | 11 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 8 | 1.411893e-03 | 11 |
| GO:MF | GO:0140097 | catalytic activity, acting on DNA | "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] | 4 | 1.627531e-03 | 11 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 4 | 2.504031e-03 | 11 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 6 | 3.058652e-03 | 11 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 6 | 4.046037e-03 | 11 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 6 | 4.064460e-03 | 11 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 6 | 4.064460e-03 | 11 |
| GO:MF | GO:0003688 | DNA replication origin binding | "Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators] | 2 | 4.847619e-03 | 11 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 6 | 1.156205e-02 | 11 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 6 | 1.349758e-02 | 11 |
| GO:MF | GO:0016853 | isomerase activity | "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] | 4 | 1.422868e-02 | 11 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 6 | 1.872649e-02 | 11 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 9 | 4.534438e-02 | 11 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011267 | Microtia, third degree | Presence of some auricular structures, but none of these structures conform to recognized ear components. | 4 | 4.514662e-07 | 11 |
| HP | HP:0009939 | Mandibular aplasia | Absence of the mandible. | 4 | 9.772511e-07 | 11 |
| HP | HP:0009892 | Anotia | Complete absence of any auricular structures. | 4 | 1.367504e-06 | 11 |
| HP | HP:0100783 | Breast aplasia | Failure to develop and congenital absence of the breast. | 4 | 3.246790e-06 | 11 |
| HP | HP:0006660 | Aplastic clavicle | Absence of the clavicles as a developmental defect. | 4 | 5.282621e-06 | 11 |
| HP | HP:0006443 | Patellar aplasia | Absence of the patella. | 4 | 8.149260e-06 | 11 |
| HP | HP:0000039 | Epispadias | Epispadias is a urogenital malformation characterized by the failure of the urethral tube to tubularize on the dorsal aspect. Unlike in hypospadias, where the meatus is on the ventral aspect, children with epispadias have a wide-open urethral plate on the dorsum. It is commonly seen as a component in the spectrum of bladder exstrophy-epispadias-complex. Isolated epispadias constitutes less than 10 percent of the total cases of epispadias. | 4 | 3.221721e-05 | 11 |
| HP | HP:0040255 | Aplasia/Hypoplasia of the clitoris | Aplasia/Hypoplasia of the clitoris | 4 | 4.264042e-05 | 11 |
| HP | HP:0000060 | Clitoral hypoplasia | Developmental hypoplasia of the clitoris. | 4 | 4.264042e-05 | 11 |
| HP | HP:0000064 | Hypoplastic labia minora | Hypoplastic labia minora | 4 | 4.870878e-05 | 11 |
| HP | HP:0006498 | Aplasia/Hypoplasia of the patella | Absence or underdevelopment of the patella. | 4 | 4.870878e-05 | 11 |
| HP | HP:0000059 | Hypoplastic labia majora | Undergrowth of the outer labia. | 4 | 9.969982e-05 | 11 |
| HP | HP:0012880 | Abnormal labia minora morphology | An anomaly of the labia minora, the folds of skin between the outer labia. | 4 | 9.969982e-05 | 11 |
| HP | HP:0012881 | Abnormal labia majora morphology | An anomaly of the outer labia. | 4 | 2.195725e-04 | 11 |
| HP | HP:0003100 | Slender long bone | Reduced diameter of a long bone. | 4 | 2.615668e-04 | 11 |
| HP | HP:0006710 | Aplasia/Hypoplasia of the clavicles | Absence or underdevelopment of the clavicles (collar bones). | 4 | 3.926980e-04 | 11 |
| HP | HP:0000413 | Atresia of the external auditory canal | Absence or failure to form of the external auditory canal. | 4 | 5.676209e-04 | 11 |
| HP | HP:0000066 | Labial hypoplasia | Labial hypoplasia | 4 | 7.449058e-04 | 11 |
| HP | HP:0003561 | Birth length less than 3rd percentile | Birth length less than 3rd percentile | 3 | 7.870926e-04 | 11 |
| HP | HP:0012815 | Hypoplastic female external genitalia | Underdevelopment of part or all of the female external reproductive organs (which include the mons pubis, labia majora, labia minora, Bartholin glands, and clitoris). | 4 | 9.605627e-04 | 11 |
| HP | HP:0008665 | Clitoral hypertrophy | Hypertrophy of the clitoris. | 4 | 1.150543e-03 | 11 |
| HP | HP:0040253 | Increased size of the clitoris | Increased size of the clitoris | 4 | 1.150543e-03 | 11 |
| HP | HP:0040252 | Abnormal size of the clitoris | Abnormal size of the clitoris | 4 | 1.150543e-03 | 11 |
| HP | HP:0010311 | Aplasia/Hypoplasia of the breasts | Absence or underdevelopment of the breasts. | 4 | 1.367231e-03 | 11 |
| HP | HP:0000176 | Submucous cleft hard palate | Hard-palate submucous clefts are characterized by bony defects in the midline of the bony palate that are covered by the mucous membrane of the roof of the mouth. It may be possible to detect a submucous cleft hard palate upon palpation as a notch in the bony palate. | 4 | 1.445800e-03 | 11 |
| HP | HP:0410005 | Cleft hard palate | Cleft hard palate | 4 | 1.527688e-03 | 11 |
| HP | HP:0003042 | Elbow dislocation | Dislocation of the distal humerus out of the elbow joint, where the radius, ulna, and humerus meet. | 4 | 2.093853e-03 | 11 |
| HP | HP:0100737 | Abnormal hard palate morphology | Abnormal hard palate morphology | 4 | 2.549583e-03 | 11 |
| HP | HP:0000058 | Abnormal labia morphology | An anomaly of the labia, the externally visible portions of the vulva. | 4 | 2.674209e-03 | 11 |
| HP | HP:5201016 | Submucous cleft palate | A cleft of the muscular portion of the palate that is covered by mucous membrane. | 4 | 2.674209e-03 | 11 |
| HP | HP:0030310 | Upper extremity joint dislocation | Displacement or malalignment of one or more joints in the upper extremity (arm). | 4 | 3.366667e-03 | 11 |
| HP | HP:0000056 | Abnormal clitoris morphology | Any structural abnormality of the clitoris. | 4 | 4.184541e-03 | 11 |
| HP | HP:0000372 | Abnormal auditory canal morphology | Any structural abnormality of the external acoustic tube (also known as the auditory canal). | 4 | 4.184541e-03 | 11 |
| HP | HP:0002878 | Respiratory failure | A severe form of respiratory insufficiency characterized by inadequate gas exchange such that the levels of oxygen or carbon dioxide cannot be maintained within normal limits. | 5 | 6.698062e-03 | 11 |
| HP | HP:0003510 | Severe short stature | A severe degree of short stature, more than -4 SD from the mean corrected for age and sex. | 4 | 7.000360e-03 | 11 |
| HP | HP:0003045 | Abnormal patella morphology | Abnormality of the patella (knee cap). | 4 | 7.263552e-03 | 11 |
| HP | HP:0000889 | Abnormal clavicle morphology | Any abnormality of the clavicles (collar bones). | 4 | 9.317251e-03 | 11 |
| HP | HP:0000327 | Hypoplasia of the maxilla | Abnormally small dimension of the Maxilla. Usually creating a malocclusion or malalignment between the upper and lower teeth or resulting in a deficient amount of projection of the base of the nose and lower midface region. | 4 | 1.468148e-02 | 11 |
| HP | HP:0003508 | Proportionate short stature | A kind of short stature in which different regions of the body are shortened to a comparable extent. | 4 | 2.733456e-02 | 11 |
| HP | HP:0000326 | Abnormal maxilla morphology | An abnormality of the Maxilla (upper jaw bone). | 4 | 2.805481e-02 | 11 |
| HP | HP:0002705 | High, narrow palate | The presence of a high and narrow palate. | 4 | 2.953736e-02 | 11 |
| HP | HP:0000055 | Abnormal female external genitalia morphology | Any structural abnormality of the female external genitalia. | 4 | 3.107714e-02 | 11 |
| HP | HP:0000193 | Bifid uvula | Uvula separated into two parts most easily seen at the tip. | 4 | 4.159706e-02 | 11 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00516_1 | Factor: E2F-1; motif: TTTSGCGCGMNR; match class: 1 | Factor: E2F-1; motif: TTTSGCGCGMNR; match class: 1 | 10 | 0.000003 | 11 |
| TF | TF:M00431_1 | Factor: E2F-1; motif: TTTSGCGS; match class: 1 | Factor: E2F-1; motif: TTTSGCGS; match class: 1 | 10 | 0.000006 | 11 |
| TF | TF:M00919_1 | Factor: E2F; motif: NCSCGCSAAAN; match class: 1 | Factor: E2F; motif: NCSCGCSAAAN; match class: 1 | 8 | 0.000283 | 11 |
| TF | TF:M00939_1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | 8 | 0.000582 | 11 |
| TF | TF:M00427_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 10 | 0.001153 | 11 |
| TF | TF:M00739_1 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 | 7 | 0.001281 | 11 |
| TF | TF:M00050_1 | Factor: E2F; motif: TTTSGCGC; match class: 1 | Factor: E2F; motif: TTTSGCGC; match class: 1 | 8 | 0.001387 | 11 |
| TF | TF:M00918_1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | 7 | 0.001733 | 11 |
| TF | TF:M00738_1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | 10 | 0.001764 | 11 |
| TF | TF:M00920_1 | Factor: E2F; motif: NKCGCGCSAAAN; match class: 1 | Factor: E2F; motif: NKCGCGCSAAAN; match class: 1 | 7 | 0.002243 | 11 |
| TF | TF:M00426_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 11 | 0.002540 | 11 |
| TF | TF:M09893_1 | Factor: E2F-3; motif: NNGGCGGGAAA; match class: 1 | Factor: E2F-3; motif: NNGGCGGGAAA; match class: 1 | 7 | 0.002765 | 11 |
| TF | TF:M00740_1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | 10 | 0.006817 | 11 |
| TF | TF:M11537 | Factor: E2F-8; motif: NNTTCCCGCCAAAW | Factor: E2F-8; motif: NNTTCCCGCCAAAW | 5 | 0.008581 | 11 |
| TF | TF:M08875_1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | 7 | 0.015721 | 11 |
| TF | TF:M00431 | Factor: E2F-1; motif: TTTSGCGS | Factor: E2F-1; motif: TTTSGCGS | 11 | 0.029226 | 11 |
| TF | TF:M00737_1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | 8 | 0.042743 | 11 |
| TF | TF:M00918 | Factor: E2F; motif: TTTSGCGSG | Factor: E2F; motif: TTTSGCGSG | 10 | 0.046125 | 11 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2204 | MCM8-ORC2-CDC6 complex | MCM8-ORC2-CDC6 complex | 2 | 0.001265 | 11 |
| CORUM | CORUM:2210 | BRCA1-IRIS-pre-replication complex | BRCA1-IRIS-pre-replication complex | 2 | 0.002527 | 11 |
| CORUM | CORUM:1038 | ORC 1-5 complex (origin recognition 1-5 complex) | ORC 1-5 complex (origin recognition 1-5 complex) | 2 | 0.004207 | 11 |
| CORUM | CORUM:1033 | ORC complex (origin recognition complex) | ORC complex (origin recognition complex) | 2 | 0.006304 | 11 |
| CORUM | CORUM:1031 | ORC complex (origin recognition complex) | ORC complex (origin recognition complex) | 2 | 0.006304 | 11 |
| CORUM | CORUM:389 | ORC complex (origin recognition complex) | ORC complex (origin recognition complex) | 2 | 0.006304 | 11 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 6 | 0.002183 | 11 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0030433 | Appendix; germinal center cells[High] | Appendix; germinal center cells[High] | 3 | 0.005062 | 11 |
| HPA | HPA:0570781 | Testis; preleptotene spermatocytes[≥Low] | Testis; preleptotene spermatocytes[≥Low] | 7 | 0.013491 | 11 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 4 | 0.018844 | 11 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 4 | 0.021207 | 11 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 4 | 0.027554 | 11 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 4 | 0.031200 | 11 |
Community 12
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 9 | 3.148923e-13 | 12 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-72163 | mRNA Splicing - Major Pathway | mRNA Splicing - Major Pathway | 8 | 2.795638e-11 | 12 |
| REAC | REAC:R-HSA-72172 | mRNA Splicing | mRNA Splicing | 8 | 3.686865e-11 | 12 |
| REAC | REAC:R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | Processing of Capped Intron-Containing Pre-mRNA | 8 | 3.505825e-10 | 12 |
| REAC | REAC:R-HSA-72165 | mRNA Splicing - Minor Pathway | mRNA Splicing - Minor Pathway | 5 | 4.453033e-08 | 12 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 8 | 6.902398e-07 | 12 |
| REAC | REAC:R-HSA-194441 | Metabolism of non-coding RNA | Metabolism of non-coding RNA | 3 | 2.170172e-03 | 12 |
| REAC | REAC:R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | SARS-CoV-2 modulates host translation machinery | 3 | 2.170172e-03 | 12 |
| REAC | REAC:R-HSA-191859 | snRNP Assembly | snRNP Assembly | 3 | 2.170172e-03 | 12 |
| REAC | REAC:R-HSA-73856 | RNA Polymerase II Transcription Termination | RNA Polymerase II Transcription Termination | 3 | 4.525828e-03 | 12 |
| REAC | REAC:R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | SLBP independent Processing of Histone Pre-mRNAs | 2 | 7.491335e-03 | 12 |
| REAC | REAC:R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 2 | 9.152192e-03 | 12 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2755 | 17S U2 snRNP | 17S U2 snRNP | 7 | 4.269755e-11 | 12 |
| CORUM | CORUM:351 | Spliceosome | Spliceosome | 8 | 4.695412e-08 | 12 |
| CORUM | CORUM:430 | 18S U11/U12 snRNP | 18S U11/U12 snRNP | 5 | 4.007981e-07 | 12 |
| CORUM | CORUM:1068 | 12S U11 snRNP | 12S U11 snRNP | 4 | 6.768804e-06 | 12 |
| CORUM | CORUM:835 | 6S methyltransferase and RG-containing Sm proteins complex | 6S methyltransferase and RG-containing Sm proteins complex | 3 | 1.151974e-04 | 12 |
| CORUM | CORUM:1142 | SMN complex | SMN complex | 3 | 1.840293e-04 | 12 |
| CORUM | CORUM:1143 | SMN complex | SMN complex | 3 | 1.185075e-03 | 12 |
| CORUM | CORUM:1745 | SMN complex | SMN complex | 3 | 1.185075e-03 | 12 |
| CORUM | CORUM:1743 | (E.F.G) complex | (E.F.G) complex | 2 | 4.192434e-03 | 12 |
| CORUM | CORUM:1181 | C complex spliceosome | C complex spliceosome | 4 | 8.361215e-03 | 12 |
| CORUM | CORUM:3118 | SMN1-SIP1-SNRP complex | SMN1-SIP1-SNRP complex | 2 | 1.393072e-02 | 12 |
| CORUM | CORUM:2757 | SMN complex, U7 snRNA specific | SMN complex, U7 snRNA specific | 2 | 2.086312e-02 | 12 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005689 | U12-type spliceosomal complex | "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955] | 5 | 8.987572e-11 | 12 |
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 7 | 2.141038e-10 | 12 |
| GO:CC | GO:0071011 | precatalytic spliceosome | "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] | 5 | 4.224764e-09 | 12 |
| GO:CC | GO:0005684 | U2-type spliceosomal complex | "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900] | 5 | 6.019025e-08 | 12 |
| GO:CC | GO:0034715 | pICln-Sm protein complex | "A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG." [GOC:mah, PMID:11713266] | 3 | 1.958058e-07 | 12 |
| GO:CC | GO:0071005 | U2-type precatalytic spliceosome | "A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] | 4 | 8.057155e-07 | 12 |
| GO:CC | GO:0034709 | methylosome | "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452] | 3 | 2.794717e-06 | 12 |
| GO:CC | GO:0034719 | SMN-Sm protein complex | "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408] | 3 | 7.962940e-06 | 12 |
| GO:CC | GO:0071013 | catalytic step 2 spliceosome | "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 4 | 9.253834e-06 | 12 |
| GO:CC | GO:0005686 | U2 snRNP | "A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] | 4 | 1.467272e-05 | 12 |
| GO:CC | GO:0071007 | U2-type catalytic step 2 spliceosome | "A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 3 | 3.949087e-05 | 12 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 10 | 6.629278e-05 | 12 |
| GO:CC | GO:0005682 | U5 snRNP | "A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] | 3 | 1.113011e-04 | 12 |
| GO:CC | GO:0005683 | U7 snRNP | "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004] | 2 | 5.056523e-04 | 12 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 8 | 6.530402e-04 | 12 |
| GO:CC | GO:0005687 | U4 snRNP | "A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] | 3 | 7.025044e-04 | 12 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 10 | 8.708729e-04 | 12 |
| GO:CC | GO:0034708 | methyltransferase complex | "A protein complex that possesses methyltransferase activity." [GOC:mah] | 3 | 1.686467e-03 | 12 |
| GO:CC | GO:0005685 | U1 snRNP | "A ribonucleoprotein complex that contains small nuclear RNA U1, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U1 snRNP, most of which remain associated with the U1 snRNA both while the U1 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] | 3 | 3.790842e-03 | 12 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 10 | 5.438393e-03 | 12 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 10 | 5.438393e-03 | 12 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 10 | 5.438393e-03 | 12 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 7 | 8.531434e-03 | 12 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 11 | 1.855441e-02 | 12 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP411 | mRNA processing | mRNA processing | 7 | 4.729211e-10 | 12 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 11 | 2.061092e-07 | 12 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 11 | 1.027501e-04 | 12 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1903241 | U2-type prespliceosome assembly | "The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome." [GO_REF:0000079, GOC:TermGenie, PMID:12374752] | 4 | 6.373713e-07 | 12 |
| GO:BP | GO:0036261 | 7-methylguanosine cap hypermethylation | "Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation." [GOC:bf, GOC:BHF, GOC:krc, GOC:mah, GOC:rl, PMID:11983179, PMID:18775984] | 3 | 7.445697e-06 | 12 |
| GO:BP | GO:0000398 | mRNA splicing, via spliceosome | "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] | 9 | 8.172085e-06 | 12 |
| GO:BP | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] | 9 | 8.172085e-06 | 12 |
| GO:BP | GO:0000375 | RNA splicing, via transesterification reactions | "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] | 9 | 8.345059e-06 | 12 |
| GO:BP | GO:0008380 | RNA splicing | "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] | 9 | 1.701740e-05 | 12 |
| GO:BP | GO:0006397 | mRNA processing | "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] | 9 | 2.137928e-05 | 12 |
| GO:BP | GO:0016071 | mRNA metabolic process | "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 9 | 6.554530e-05 | 12 |
| GO:BP | GO:0036260 | RNA capping | "The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts." [GOC:bf, GOC:krc, GOC:mah, PMID:18775984, PMID:27383794, PMID:29681497, PMID:30353673] | 3 | 7.428711e-05 | 12 |
| GO:BP | GO:0000245 | spliceosomal complex assembly | "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] | 5 | 5.088078e-04 | 12 |
| GO:BP | GO:0000966 | RNA 5'-end processing | "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc] | 3 | 1.112074e-03 | 12 |
| GO:BP | GO:0043484 | regulation of RNA splicing | "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] | 4 | 2.380324e-03 | 12 |
| GO:BP | GO:0006396 | RNA processing | "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] | 9 | 3.078328e-03 | 12 |
| GO:BP | GO:0001510 | RNA methylation | "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd, PMID:21823225] | 3 | 1.110994e-02 | 12 |
| GO:BP | GO:0048024 | regulation of mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 3 | 2.941667e-02 | 12 |
| GO:BP | GO:0043414 | macromolecule methylation | "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:go_curators] | 3 | 4.284306e-02 | 12 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 6 | 0.002376 | 12 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 4 | 0.003432 | 12 |
| HPA | HPA:0570782 | Testis; preleptotene spermatocytes[≥Medium] | Testis; preleptotene spermatocytes[≥Medium] | 6 | 0.014521 | 12 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 5 | 0.015149 | 12 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 5 | 0.016533 | 12 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 5 | 0.022972 | 12 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 5 | 0.024393 | 12 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 4 | 0.028898 | 12 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 5 | 0.032407 | 12 |
| HPA | HPA:0570793 | Testis; round or early spermatids[High] | Testis; round or early spermatids[High] | 5 | 0.033947 | 12 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 4 | 0.043291 | 12 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M08458_1 | Factor: Erm:C/EBPdelta; motif: RSCGGAWRTTGCGYAAY; match class: 1 | Factor: Erm:C/EBPdelta; motif: RSCGGAWRTTGCGYAAY; match class: 1 | 9 | 0.00421 | 12 |
Community 13
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 9 | 4.512431e-12 | 13 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 9 | 2.879239e-11 | 13 |
| GO:MF | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] | 8 | 7.221016e-10 | 13 |
| GO:MF | GO:0001216 | DNA-binding transcription activator activity | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018] | 8 | 8.111501e-10 | 13 |
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 7 | 8.651330e-09 | 13 |
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 10 | 1.239627e-08 | 13 |
| GO:MF | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] | 9 | 5.497138e-08 | 13 |
| GO:MF | GO:0000976 | transcription cis-regulatory region binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] | 9 | 1.013240e-07 | 13 |
| GO:MF | GO:0001067 | transcription regulatory region nucleic acid binding | "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] | 9 | 1.019366e-07 | 13 |
| GO:MF | GO:1990837 | sequence-specific double-stranded DNA binding | "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] | 9 | 1.461259e-07 | 13 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 10 | 1.730299e-07 | 13 |
| GO:MF | GO:0043425 | bHLH transcription factor binding | "Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] | 4 | 1.934760e-07 | 13 |
| GO:MF | GO:0003690 | double-stranded DNA binding | "Binding to double-stranded DNA." [GOC:elh, GOC:vw] | 9 | 2.517754e-07 | 13 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 9 | 2.701491e-07 | 13 |
| GO:MF | GO:0001221 | transcription coregulator binding | "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] | 5 | 2.744187e-07 | 13 |
| GO:MF | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018] | 8 | 9.708616e-07 | 13 |
| GO:MF | GO:0000987 | cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018] | 8 | 1.130654e-06 | 13 |
| GO:MF | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018] | 8 | 2.922737e-06 | 13 |
| GO:MF | GO:0003700 | DNA-binding transcription factor activity | "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] | 8 | 4.792906e-06 | 13 |
| GO:MF | GO:0070411 | I-SMAD binding | "Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 3 | 8.741637e-06 | 13 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 6 | 3.195412e-05 | 13 |
| GO:MF | GO:0070412 | R-SMAD binding | "Binding to a receptor-regulated SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 3 | 4.048100e-05 | 13 |
| GO:MF | GO:0001223 | transcription coactivator binding | "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] | 3 | 2.510889e-04 | 13 |
| GO:MF | GO:0001222 | transcription corepressor binding | "Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc] | 3 | 2.851471e-04 | 13 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 10 | 3.474251e-04 | 13 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 6 | 9.123203e-04 | 13 |
| GO:MF | GO:0046332 | SMAD binding | "Binding to a SMAD signaling protein." [GOC:ai] | 3 | 1.214401e-03 | 13 |
| GO:MF | GO:0070410 | co-SMAD binding | "Binding to a common mediator SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 2 | 2.609008e-03 | 13 |
| GO:MF | GO:0010484 | histone H3 acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [PMID:19056256] | 2 | 4.147414e-03 | 13 |
| GO:MF | GO:0031490 | chromatin DNA binding | "Binding to DNA that is assembled into chromatin." [GOC:mah] | 3 | 8.311344e-03 | 13 |
| GO:MF | GO:0035035 | histone acetyltransferase binding | "Binding to an histone acetyltransferase." [GOC:bf] | 2 | 1.087595e-02 | 13 |
| GO:MF | GO:0005160 | transforming growth factor beta receptor binding | "Binding to a transforming growth factor beta receptor." [GOC:ai] | 2 | 1.280008e-02 | 13 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 6 | 3.300066e-02 | 13 |
| GO:MF | GO:0004402 | histone acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48, PMID:19056256] | 2 | 3.879627e-02 | 13 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 6 | 4.015551e-02 | 13 |
| GO:MF | GO:0061733 | protein-lysine-acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide. The acetyl group is transferred to the nitrogen atom at position 6 of the lysine residue in the protein." [GOC:dph, RHEA:45948] | 2 | 4.603671e-02 | 13 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9614085 | FOXO-mediated transcription | FOXO-mediated transcription | 7 | 6.542965e-12 | 13 |
| REAC | REAC:R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | SMAD4 MH2 Domain Mutants in Cancer | 3 | 1.484902e-07 | 13 |
| REAC | REAC:R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | SMAD2/3 MH2 Domain Mutants in Cancer | 3 | 1.484902e-07 | 13 |
| REAC | REAC:R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | Loss of Function of SMAD4 in Cancer | 3 | 1.484902e-07 | 13 |
| REAC | REAC:R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | Loss of Function of SMAD2/3 in Cancer | 3 | 2.965554e-06 | 13 |
| REAC | REAC:R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | Signaling by TGF-beta Receptor Complex in Cancer | 3 | 5.187242e-06 | 13 |
| REAC | REAC:R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4 | 5.488387e-06 | 13 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 9 | 6.754804e-06 | 13 |
| REAC | REAC:R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | Activation of gene expression by SREBF (SREBP) | 4 | 8.500248e-06 | 13 |
| REAC | REAC:R-HSA-9758941 | Gastrulation | Gastrulation | 5 | 1.154776e-05 | 13 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 9 | 1.554386e-05 | 13 |
| REAC | REAC:R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4 | 2.132686e-05 | 13 |
| REAC | REAC:R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4 | 2.708139e-05 | 13 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 9 | 4.268093e-05 | 13 |
| REAC | REAC:R-HSA-9823730 | Formation of definitive endoderm | Formation of definitive endoderm | 3 | 6.717705e-05 | 13 |
| REAC | REAC:R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 3 | 6.717705e-05 | 13 |
| REAC | REAC:R-HSA-9614657 | FOXO-mediated transcription of cell death genes | FOXO-mediated transcription of cell death genes | 3 | 8.263997e-05 | 13 |
| REAC | REAC:R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | FOXO-mediated transcription of cell cycle genes | 3 | 1.003006e-04 | 13 |
| REAC | REAC:R-HSA-1502540 | Signaling by Activin | Signaling by Activin | 3 | 1.003006e-04 | 13 |
| REAC | REAC:R-HSA-9754189 | Germ layer formation at gastrulation | Germ layer formation at gastrulation | 3 | 1.003006e-04 | 13 |
| REAC | REAC:R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | NOTCH4 Intracellular Domain Regulates Transcription | 3 | 1.679103e-04 | 13 |
| REAC | REAC:R-HSA-170834 | Signaling by TGF-beta Receptor Complex | Signaling by TGF-beta Receptor Complex | 4 | 2.540339e-04 | 13 |
| REAC | REAC:R-HSA-1181150 | Signaling by NODAL | Signaling by NODAL | 3 | 2.604765e-04 | 13 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 4 | 2.890551e-04 | 13 |
| REAC | REAC:R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3 | 5.358874e-04 | 13 |
| REAC | REAC:R-HSA-1989781 | PPARA activates gene expression | PPARA activates gene expression | 4 | 5.800148e-04 | 13 |
| REAC | REAC:R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 3 | 5.951460e-04 | 13 |
| REAC | REAC:R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | Regulation of lipid metabolism by PPARalpha | 4 | 6.008423e-04 | 13 |
| REAC | REAC:R-HSA-9006936 | Signaling by TGFB family members | Signaling by TGFB family members | 4 | 7.881035e-04 | 13 |
| REAC | REAC:R-HSA-8957322 | Metabolism of steroids | Metabolism of steroids | 4 | 1.892683e-03 | 13 |
| REAC | REAC:R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | RUNX3 regulates BCL2L11 (BIM) transcription | 2 | 2.039143e-03 | 13 |
| REAC | REAC:R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | TGFBR1 KD Mutants in Cancer | 2 | 2.039143e-03 | 13 |
| REAC | REAC:R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 2 | 2.039143e-03 | 13 |
| REAC | REAC:R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | TGF-beta receptor signaling activates SMADs | 3 | 2.208247e-03 | 13 |
| REAC | REAC:R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | Loss of Function of TGFBR1 in Cancer | 2 | 3.057232e-03 | 13 |
| REAC | REAC:R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | RUNX3 regulates CDKN1A transcription | 2 | 4.278050e-03 | 13 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 5 | 6.119623e-03 | 13 |
| REAC | REAC:R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | ATF6 (ATF6-alpha) activates chaperone genes | 2 | 7.326690e-03 | 13 |
| REAC | REAC:R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | Regulation of FOXO transcriptional activity by acetylation | 2 | 9.153923e-03 | 13 |
| REAC | REAC:R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | NFE2L2 regulating tumorigenic genes | 2 | 1.118270e-02 | 13 |
| REAC | REAC:R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | ATF6 (ATF6-alpha) activates chaperones | 2 | 1.118270e-02 | 13 |
| REAC | REAC:R-HSA-9013694 | Signaling by NOTCH4 | Signaling by NOTCH4 | 3 | 1.220543e-02 | 13 |
| REAC | REAC:R-HSA-8941856 | RUNX3 regulates NOTCH signaling | RUNX3 regulates NOTCH signaling | 2 | 1.847540e-02 | 13 |
| REAC | REAC:R-HSA-9796292 | Formation of axial mesoderm | Formation of axial mesoderm | 2 | 1.847540e-02 | 13 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 3 | 1.966859e-02 | 13 |
| REAC | REAC:R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | 2 | 2.433954e-02 | 13 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 4 | 2.673242e-02 | 13 |
| REAC | REAC:R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2 | 3.846293e-02 | 13 |
| REAC | REAC:R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | Transcriptional regulation of pluripotent stem cells | 2 | 4.671749e-02 | 13 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 10 | 1.124327e-10 | 13 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 8 | 4.377902e-10 | 13 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 10 | 3.925197e-09 | 13 |
| GO:CC | GO:0071144 | heteromeric SMAD protein complex | "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020] | 3 | 4.100470e-07 | 13 |
| GO:CC | GO:0071141 | SMAD protein complex | "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020] | 3 | 6.149247e-07 | 13 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 5 | 5.274649e-06 | 13 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 10 | 7.508826e-06 | 13 |
| GO:CC | GO:0032444 | activin responsive factor complex | "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor." [PMID:12374795, PMID:9288972] | 2 | 6.086983e-05 | 13 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 10 | 1.053758e-04 | 13 |
| GO:CC | GO:0016602 | CCAAT-binding factor complex | "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851] | 2 | 2.028017e-04 | 13 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 10 | 6.742922e-04 | 13 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 10 | 6.753047e-04 | 13 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 10 | 7.010648e-04 | 13 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 10 | 7.010648e-04 | 13 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 10 | 7.010648e-04 | 13 |
| GO:CC | GO:0032993 | protein-DNA complex | "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] | 3 | 1.615788e-02 | 13 |
| GO:CC | GO:0000791 | euchromatin | "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156] | 2 | 4.030790e-02 | 13 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 10 | 4.197363e-02 | 13 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 10 | 6.503718e-10 | 13 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 10 | 1.330899e-08 | 13 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 10 | 1.346710e-08 | 13 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 10 | 2.914450e-08 | 13 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 10 | 8.260921e-08 | 13 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 10 | 8.792322e-07 | 13 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 10 | 9.318448e-07 | 13 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 10 | 1.376594e-06 | 13 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 10 | 1.455266e-06 | 13 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 10 | 1.005155e-05 | 13 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 10 | 1.443432e-05 | 13 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 10 | 1.526042e-05 | 13 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 10 | 2.159797e-05 | 13 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 10 | 2.470762e-05 | 13 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 10 | 3.164396e-05 | 13 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 10 | 6.977367e-05 | 13 |
| GO:BP | GO:0030325 | adrenal gland development | "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh] | 3 | 2.619076e-04 | 13 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] | 7 | 2.646731e-04 | 13 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] | 6 | 3.053540e-04 | 13 |
| GO:BP | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah] | 4 | 4.717958e-04 | 13 |
| GO:BP | GO:1903844 | regulation of cellular response to transforming growth factor beta stimulus | "Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] | 4 | 5.130502e-04 | 13 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 7 | 1.016408e-03 | 13 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 10 | 1.416199e-03 | 13 |
| GO:BP | GO:0018076 | N-terminal peptidyl-lysine acetylation | "The acetylation of the N-terminal lysine of proteins." [GOC:ai] | 2 | 1.419653e-03 | 13 |
| GO:BP | GO:0014888 | striated muscle adaptation | "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] | 3 | 1.444668e-03 | 13 |
| GO:BP | GO:0032924 | activin receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:rl, GOC:signaling] | 3 | 1.744944e-03 | 13 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 10 | 1.850517e-03 | 13 |
| GO:BP | GO:0007179 | transforming growth factor beta receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] | 4 | 2.168599e-03 | 13 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 10 | 2.245277e-03 | 13 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] | 7 | 2.357040e-03 | 13 |
| GO:BP | GO:0010718 | positive regulation of epithelial to mesenchymal transition | "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] | 3 | 2.464151e-03 | 13 |
| GO:BP | GO:0072132 | mesenchyme morphogenesis | "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10] | 3 | 2.887698e-03 | 13 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 10 | 2.995796e-03 | 13 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 10 | 3.620584e-03 | 13 |
| GO:BP | GO:0031669 | cellular response to nutrient levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] | 4 | 4.362953e-03 | 13 |
| GO:BP | GO:0007507 | heart development | "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] | 5 | 5.043145e-03 | 13 |
| GO:BP | GO:0072359 | circulatory system development | "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] | 6 | 5.201533e-03 | 13 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575] | 4 | 5.424337e-03 | 13 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] | 4 | 5.933427e-03 | 13 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:mah] | 4 | 6.021602e-03 | 13 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 6 | 6.258064e-03 | 13 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 10 | 6.371777e-03 | 13 |
| GO:BP | GO:0009880 | embryonic pattern specification | "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] | 3 | 6.468557e-03 | 13 |
| GO:BP | GO:0032909 | regulation of transforming growth factor beta2 production | "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] | 2 | 6.618328e-03 | 13 |
| GO:BP | GO:0032906 | transforming growth factor beta2 production | "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] | 2 | 6.618328e-03 | 13 |
| GO:BP | GO:0060395 | SMAD protein signal transduction | "An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes." [GOC:BHF] | 3 | 7.537189e-03 | 13 |
| GO:BP | GO:0048589 | developmental growth | "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] | 5 | 7.888922e-03 | 13 |
| GO:BP | GO:0008283 | cell population proliferation | "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] | 7 | 7.900422e-03 | 13 |
| GO:BP | GO:0048617 | embryonic foregut morphogenesis | "The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] | 2 | 8.507121e-03 | 13 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 10 | 9.112507e-03 | 13 |
| GO:BP | GO:0007492 | endoderm development | "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb] | 3 | 9.677141e-03 | 13 |
| GO:BP | GO:0007440 | foregut morphogenesis | "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid] | 2 | 1.063120e-02 | 13 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb] | 4 | 1.196071e-02 | 13 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 10 | 1.196308e-02 | 13 |
| GO:BP | GO:0001822 | kidney development | "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544] | 4 | 1.225832e-02 | 13 |
| GO:BP | GO:0048340 | paraxial mesoderm morphogenesis | "The process in which the anatomical structures of the paraxial mesoderm are generated and organized." [GOC:go_curators] | 2 | 1.299040e-02 | 13 |
| GO:BP | GO:0051094 | positive regulation of developmental process | "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 6 | 1.311824e-02 | 13 |
| GO:BP | GO:0072001 | renal system development | "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:6996269] | 4 | 1.382942e-02 | 13 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 10 | 1.411105e-02 | 13 |
| GO:BP | GO:0001657 | ureteric bud development | "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators] | 3 | 1.464841e-02 | 13 |
| GO:BP | GO:0072164 | mesonephric tubule development | "The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] | 3 | 1.508852e-02 | 13 |
| GO:BP | GO:0072163 | mesonephric epithelium development | "The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] | 3 | 1.508852e-02 | 13 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:22651914, PMID:28096268] | 4 | 1.590593e-02 | 13 |
| GO:BP | GO:0070482 | response to oxygen levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] | 4 | 1.590593e-02 | 13 |
| GO:BP | GO:0090100 | positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | "Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] | 3 | 1.599479e-02 | 13 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 10 | 1.612439e-02 | 13 |
| GO:BP | GO:0043500 | muscle adaptation | "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] | 3 | 1.646110e-02 | 13 |
| GO:BP | GO:0010717 | regulation of epithelial to mesenchymal transition | "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] | 3 | 1.693631e-02 | 13 |
| GO:BP | GO:0001823 | mesonephros development | "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314] | 3 | 1.693631e-02 | 13 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] | 6 | 1.795261e-02 | 13 |
| GO:BP | GO:0007178 | cell surface receptor protein serine/threonine kinase signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] | 4 | 1.986760e-02 | 13 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 10 | 2.035759e-02 | 13 |
| GO:BP | GO:1901203 | positive regulation of extracellular matrix assembly | "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] | 2 | 2.147685e-02 | 13 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 10 | 2.157643e-02 | 13 |
| GO:BP | GO:0006474 | N-terminal protein amino acid acetylation | "The acetylation of the N-terminal amino acid of proteins." [GOC:ai] | 2 | 2.477469e-02 | 13 |
| GO:BP | GO:0050793 | regulation of developmental process | "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] | 7 | 2.985693e-02 | 13 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 5 | 3.103873e-02 | 13 |
| GO:BP | GO:0014706 | striated muscle tissue development | "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle] | 4 | 3.109876e-02 | 13 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] | 6 | 3.320189e-02 | 13 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 10 | 3.535575e-02 | 13 |
| GO:BP | GO:0007498 | mesoderm development | "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] | 3 | 3.732065e-02 | 13 |
| GO:BP | GO:0060537 | muscle tissue development | "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph] | 4 | 3.820283e-02 | 13 |
| GO:BP | GO:0035270 | endocrine system development | "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system] | 3 | 3.979662e-02 | 13 |
| GO:BP | GO:0038092 | nodal signaling pathway | "The series of molecular signals initiated by nodal protein binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:vk, PMID:17287255] | 2 | 4.030643e-02 | 13 |
| GO:BP | GO:0031053 | primary miRNA processing | "A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354, PMID:25799998] | 2 | 4.030643e-02 | 13 |
| GO:BP | GO:0060039 | pericardium development | "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438] | 2 | 4.030643e-02 | 13 |
| GO:BP | GO:0040007 | growth | "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] | 5 | 4.053789e-02 | 13 |
| GO:BP | GO:1901201 | regulation of extracellular matrix assembly | "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] | 2 | 4.477356e-02 | 13 |
| GO:BP | GO:0048339 | paraxial mesoderm development | "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh] | 2 | 4.477356e-02 | 13 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] | 6 | 4.546086e-02 | 13 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 6 | 4.577365e-02 | 13 |
| GO:BP | GO:0071333 | cellular response to glucose stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah] | 3 | 4.786789e-02 | 13 |
| GO:BP | GO:0018394 | peptidyl-lysine acetylation | "The acetylation of peptidyl-lysine." [GOC:mah] | 2 | 4.947401e-02 | 13 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4879 | Overlap between signal transduction pathways contributing to LMNA laminopathies | Overlap between signal transduction pathways contributing to LMNA laminopathies | 5 | 7.092799e-08 | 13 |
| WP | WP:WP138 | Androgen receptor signaling | Androgen receptor signaling | 5 | 5.511896e-07 | 13 |
| WP | WP:WP560 | TGF beta receptor signaling | TGF beta receptor signaling | 4 | 1.258715e-05 | 13 |
| WP | WP:WP5382 | TGFB Smad signaling | TGFB Smad signaling | 3 | 1.441975e-05 | 13 |
| WP | WP:WP4816 | TGF beta receptor signaling in skeletal dysplasias | TGF beta receptor signaling in skeletal dysplasias | 4 | 1.677245e-05 | 13 |
| WP | WP:WP3874 | Canonical and non canonical TGF B signaling | Canonical and non canonical TGF B signaling | 3 | 4.447464e-05 | 13 |
| WP | WP:WP3859 | TGF beta signaling in thyroid cells for epithelial mesenchymal transition | TGF beta signaling in thyroid cells for epithelial mesenchymal transition | 3 | 6.332200e-05 | 13 |
| WP | WP:WP5103 | Progeria associated lipodystrophy | Progeria associated lipodystrophy | 3 | 1.005061e-04 | 13 |
| WP | WP:WP3668 | Hypothesized pathways in pathogenesis of cardiovascular disease | Hypothesized pathways in pathogenesis of cardiovascular disease | 3 | 1.499133e-04 | 13 |
| WP | WP:WP5036 | Angiotensin II receptor type 1 pathway | Angiotensin II receptor type 1 pathway | 3 | 2.132539e-04 | 13 |
| WP | WP:WP2870 | Extracellular vesicle mediated signaling in recipient cells | Extracellular vesicle mediated signaling in recipient cells | 3 | 2.377580e-04 | 13 |
| WP | WP:WP5474 | Catabolism of skeletal muscle in cachexia | Catabolism of skeletal muscle in cachexia | 3 | 6.398401e-04 | 13 |
| WP | WP:WP4666 | Hepatitis B infection | Hepatitis B infection | 4 | 7.611221e-04 | 13 |
| WP | WP:WP4535 | Envelope proteins and their potential roles in EDMD physiopathology | Envelope proteins and their potential roles in EDMD physiopathology | 3 | 9.805425e-04 | 13 |
| WP | WP:WP5144 | NRP1 triggered signaling in pancreatic cancer | NRP1 triggered signaling in pancreatic cancer | 3 | 1.508640e-03 | 13 |
| WP | WP:WP2324 | AGE RAGE pathway | AGE RAGE pathway | 3 | 2.930519e-03 | 13 |
| WP | WP:WP5158 | Urotensin II mediated signaling | Urotensin II mediated signaling | 3 | 3.351038e-03 | 13 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 3 | 3.971114e-03 | 13 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 5 | 3.985851e-03 | 13 |
| WP | WP:WP5356 | Affected pathways in Duchenne muscular dystrophy | Affected pathways in Duchenne muscular dystrophy | 3 | 4.137125e-03 | 13 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 3 | 6.961337e-03 | 13 |
| WP | WP:WP5367 | Rubinstein Taybi syndrome 1 | Rubinstein Taybi syndrome 1 | 2 | 1.001556e-02 | 13 |
| WP | WP:WP5345 | 1p36 copy number variation syndrome | 1p36 copy number variation syndrome | 3 | 1.082660e-02 | 13 |
| WP | WP:WP710 | DNA damage response only ATM dependent | DNA damage response only ATM dependent | 3 | 1.319754e-02 | 13 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 3 | 1.469361e-02 | 13 |
| WP | WP:WP4942 | 15q13 3 copy number variation syndrome | 15q13 3 copy number variation syndrome | 2 | 1.628124e-02 | 13 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 3 | 1.757142e-02 | 13 |
| WP | WP:WP3657 | Hematopoietic stem cell gene regulation by GABP alpha beta complex | Hematopoietic stem cell gene regulation by GABP alpha beta complex | 2 | 1.808200e-02 | 13 |
| WP | WP:WP4482 | Vitamin D in inflammatory diseases | Vitamin D in inflammatory diseases | 2 | 2.196379e-02 | 13 |
| WP | WP:WP5083 | Neuroinflammation and glutamatergic signaling | Neuroinflammation and glutamatergic signaling | 3 | 2.776292e-02 | 13 |
| WP | WP:WP2853 | Endoderm differentiation | Endoderm differentiation | 3 | 2.956128e-02 | 13 |
| WP | WP:WP2857 | Mesodermal commitment pathway | Mesodermal commitment pathway | 3 | 3.143400e-02 | 13 |
| WP | WP:WP1984 | Integrated breast cancer pathway | Integrated breast cancer pathway | 3 | 3.540794e-02 | 13 |
| WP | WP:WP706 | Sudden infant death syndrome SIDS susceptibility pathways | Sudden infant death syndrome SIDS susceptibility pathways | 3 | 4.044147e-02 | 13 |
| WP | WP:WP4239 | Epithelial to mesenchymal transition in colorectal cancer | Epithelial to mesenchymal transition in colorectal cancer | 3 | 4.196044e-02 | 13 |
| WP | WP:WP4838 | Regucalcin in proximal tubule epithelial kidney cells | Regucalcin in proximal tubule epithelial kidney cells | 2 | 4.403114e-02 | 13 |
| WP | WP:WP3414 | Initiation of transcription and translation elongation at the HIV 1 LTR | Initiation of transcription and translation elongation at the HIV 1 LTR | 2 | 4.694506e-02 | 13 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2829 | RSmad complex | RSmad complex | 4 | 1.544150e-07 | 13 |
| CORUM | CORUM:2706 | SMAD3-SMAD4-SP1 complex | SMAD3-SMAD4-SP1 complex | 3 | 6.239924e-07 | 13 |
| CORUM | CORUM:3753 | CREBBP-SMAD2-SMAD4 pentameric complex | CREBBP-SMAD2-SMAD4 pentameric complex | 3 | 6.239924e-07 | 13 |
| CORUM | CORUM:2834 | SMAD4-SMAD2-SMAD3 complex | SMAD4-SMAD2-SMAD3 complex | 3 | 6.239924e-07 | 13 |
| CORUM | CORUM:3754 | CREBBP-SMAD3-SMAD4 pentameric complex | CREBBP-SMAD3-SMAD4 pentameric complex | 3 | 6.239924e-07 | 13 |
| CORUM | CORUM:3750 | CREBBP-SMAD3 hexameric complex | CREBBP-SMAD3 hexameric complex | 2 | 4.219436e-04 | 13 |
| CORUM | CORUM:2641 | CREBBP-KAT2B-MYOD1 complex | CREBBP-KAT2B-MYOD1 complex | 2 | 4.219436e-04 | 13 |
| CORUM | CORUM:3740 | SKI-SMAD3-SMAD4 complex | SKI-SMAD3-SMAD4 complex | 2 | 4.219436e-04 | 13 |
| CORUM | CORUM:3749 | CREBBP-SMAD2 hexameric complex | CREBBP-SMAD2 hexameric complex | 2 | 4.219436e-04 | 13 |
| CORUM | CORUM:3959 | SKI-SMAD3-SMAD4 complex, TGF(beta)-dependent | SKI-SMAD3-SMAD4 complex, TGF(beta)-dependent | 2 | 4.219436e-04 | 13 |
| CORUM | CORUM:3739 | SKI-SMAD2-SMAD4 pentameric complex | SKI-SMAD2-SMAD4 pentameric complex | 2 | 4.219436e-04 | 13 |
| CORUM | CORUM:3038 | SMAD2-SMAD4-FAST1 complex | SMAD2-SMAD4-FAST1 complex | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:2705 | SMAD3-SMAD4-CTCF protein-DNA complex | SMAD3-SMAD4-CTCF protein-DNA complex | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:2830 | TIF1gamma-SMAD2-SMAD3 complex | TIF1gamma-SMAD2-SMAD3 complex | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:6646 | SMAD2-SMAD4-WWTR1 complex | SMAD2-SMAD4-WWTR1 complex | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:3062 | RNA polymerase II complex, (CBP, RPBI, PCAF, BAF47), chromatin structure modifying | RNA polymerase II complex, (CBP, RPBI, PCAF, BAF47), chromatin structure modifying | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:2762 | SMAD3-SMAD4-FOXO4 complex | SMAD3-SMAD4-FOXO4 complex | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:2761 | SMAD3-SMAD4-FOXO1 complex | SMAD3-SMAD4-FOXO1 complex | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:2760 | SMAD3-SMAD4-FOXO3 complex | SMAD3-SMAD4-FOXO3 complex | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:2708 | SMAD3-SMAD4-cJUN complex | SMAD3-SMAD4-cJUN complex | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:6649 | SMAD3-SMAD4-WWTR1 complex | SMAD3-SMAD4-WWTR1 complex | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:3233 | SMAD2-SMAD4-FAST1-TGIF complex, TGF(beta) induced | SMAD2-SMAD4-FAST1-TGIF complex, TGF(beta) induced | 2 | 2.526672e-03 | 13 |
| CORUM | CORUM:1827 | PML-SMAD2/3-SARA complex | PML-SMAD2/3-SARA complex | 2 | 2.526672e-03 | 13 |
| CORUM | CORUM:2692 | SMAD3-SMAD4-cJun-cFos complex | SMAD3-SMAD4-cJun-cFos complex | 2 | 2.526672e-03 | 13 |
| CORUM | CORUM:2707 | SMAD3-SMAD4-FOXO3-FOXG1 complex | SMAD3-SMAD4-FOXO3-FOXG1 complex | 2 | 2.526672e-03 | 13 |
| CORUM | CORUM:2754 | JUND-FOSB-SMAD3-SMAD4 complex | JUND-FOSB-SMAD3-SMAD4 complex | 2 | 2.526672e-03 | 13 |
| CORUM | CORUM:3061 | RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying | RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying | 2 | 2.526672e-03 | 13 |
| CORUM | CORUM:4 | Multisubunit ACTR coactivator complex | Multisubunit ACTR coactivator complex | 2 | 2.526672e-03 | 13 |
| CORUM | CORUM:3234 | SMAD2-SMAD4-FAST1-TGIF-HDAC1 complex, TGF(beta) induced | SMAD2-SMAD4-FAST1-TGIF-HDAC1 complex, TGF(beta) induced | 2 | 4.206968e-03 | 13 |
| CORUM | CORUM:3137 | MASH1 promoter-coactivator complex | MASH1 promoter-coactivator complex | 2 | 4.206968e-03 | 13 |
| CORUM | CORUM:1474 | SMAD3/4-E2F4/5-p107-DP1 complex | SMAD3/4-E2F4/5-p107-DP1 complex | 2 | 6.304228e-03 | 13 |
| CORUM | CORUM:3142 | CAMK2-delta-MASH1 promoter-coactivator complex | CAMK2-delta-MASH1 promoter-coactivator complex | 2 | 6.304228e-03 | 13 |
| CORUM | CORUM:3066 | RNA polymerase II complex, chromatin structure modifying | RNA polymerase II complex, chromatin structure modifying | 2 | 2.300171e-02 | 13 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 6 | 0.000003 | 13 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | TGF-beta signaling pathway | 5 | 0.000004 | 13 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 4 | 0.001333 | 13 |
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 4 | 0.001333 | 13 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 3 | 0.004862 | 13 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 3 | 0.007034 | 13 |
| KEGG | KEGG:04520 | Adherens junction | Adherens junction | 3 | 0.008880 | 13 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 5 | 0.010802 | 13 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | AGE-RAGE signaling pathway in diabetic complications | 3 | 0.011017 | 13 |
| KEGG | KEGG:04659 | Th17 cell differentiation | Th17 cell differentiation | 3 | 0.012732 | 13 |
| KEGG | KEGG:04068 | FoxO signaling pathway | FoxO signaling pathway | 3 | 0.024469 | 13 |
| KEGG | KEGG:04371 | Apelin signaling pathway | Apelin signaling pathway | 3 | 0.028514 | 13 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | Signaling pathways regulating pluripotency of stem cells | 3 | 0.031652 | 13 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 3 | 0.035005 | 13 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 3 | 0.045590 | 13 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 3 | 0.048951 | 13 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0200146 | Mucoid extracellular matrix accumulation | An increase of medial mucoid extracellular matrix creating translamellar and/or intralamellar expansions including extracellular pools as noted on an H&E stain and/or a stain to highlight extracellular matrix material (Movat's pentachrome, Alcian blue, etc.). | 3 | 0.000864 | 13 |
| HP | HP:0012180 | Cystic medial necrosis | A disorder of large arteries, in particular the aorta, characterized by an accumulation of basophilic ground substance in the media with cyst-like lesions associated with degenerative changes of collagen, elastin and the vascular smooth muscle cells. | 3 | 0.000864 | 13 |
| HP | HP:0032079 | Medial degeneration | Medial degeneration of the aorta is to be used as an overarching term for any aortic surgical specimens that demonstrate one or more of the specific histopathologies mucoid extracellular matrix accumulation, elastic fiber fragmentation and/or loss, elastic fiber thinning, elastic fiber disorganization, smooth muscle cell nuclei loss, laminar medial collapse, smooth muscle cell disorganization, medial fibrosis. Grading of medial degeneration is based on the average overall severity of specific histopathologies as described, considering the worst area(s) sampled from multiple slides and aorta sections. | 3 | 0.000864 | 13 |
| HP | HP:0004959 | Descending thoracic aorta aneurysm | An abnormal localized widening (dilatation) of the descending thoracic aorta. | 3 | 0.000864 | 13 |
| HP | HP:0012763 | Paroxysmal dyspnea | A sudden attack of dyspnea that occurs while the affected person is at rest. | 3 | 0.001016 | 13 |
| HP | HP:0012499 | Descending aortic dissection | A separation of the layers within the wall of the descending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space. | 3 | 0.001185 | 13 |
| HP | HP:0012163 | Carotid artery dilatation | A dilatation (balooning or bulging out of the vessel wall) of a carotid artery. | 3 | 0.001576 | 13 |
| HP | HP:0005112 | Abdominal aortic aneurysm | An abnormal localized widening (dilatation) of the abdominal aorta. | 3 | 0.001801 | 13 |
| HP | HP:0100775 | Dural ectasia | A widening or ballooning of the dural sac surrounding the spinal cord usually at the lumbosacral level. | 3 | 0.001801 | 13 |
| HP | HP:0010303 | Abnormal spinal meningeal morphology | Any abnormality of the spinal meninges, the system of membranes (dura mater, the arachnoid mater, and the pia mater) which envelops the spinal cord. | 3 | 0.002045 | 13 |
| HP | HP:0012432 | Chronic fatigue | Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer. | 3 | 0.002045 | 13 |
| HP | HP:0004933 | Ascending aortic dissection | A separation of the layers within the wall of the ascending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space. | 3 | 0.002311 | 13 |
| HP | HP:0031784 | Abnormal ascending aorta morphology | Any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise. | 3 | 0.002599 | 13 |
| HP | HP:0001647 | Bicuspid aortic valve | The presence of an aortic valve with two instead of the normal three cusps (flaps). Bicuspid aortic valvue is a malformation of a commissure (small space between the attachment of each cusp to the aortic wall) and the adjacent parts of the two corresponding cusps forming a raphe (the fused area of the two underdeveloped cusps turning into a malformed commissure between both cusps; the raphe is a fibrous ridge that extends from the commissure to the free edge of the two underdeveloped, conjoint cusps). | 4 | 0.004343 | 13 |
| HP | HP:0011106 | Hypovolemia | An decrease in the amount of intravascular fluid, particularly in the volume of the circulating blood. | 3 | 0.004397 | 13 |
| HP | HP:0011104 | Abnormality of blood volume homeostasis | An abnormality in the amount of volume occupied by intravascular blood. | 3 | 0.004397 | 13 |
| HP | HP:0031567 | Abnormal aortic valve cusp morphology | Any structural anomaly of the aortic valve leaflets. | 4 | 0.004638 | 13 |
| HP | HP:0004950 | Peripheral arterial stenosis | Narrowing of peripheral arteries with reduction of blood flow to the limbs. This feature may be quantified as an ankle-brachial index of less than 0.9, and may be manifested clinically as claudication. | 3 | 0.004834 | 13 |
| HP | HP:0002140 | Ischemic stroke | Acute ischemic stroke (AIS) is defined by the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. It is caused by thrombosis or embolism that occludes a cerebral vessel supplying a specific area of the brain. During a vessel occlusion, there is a core area where damage to the brain is irreversible and an area of penumbra where the brain has lost function owing to decreased blood flow but is not irreversibly injured. | 3 | 0.007458 | 13 |
| HP | HP:0001642 | Pulmonic stenosis | A narrowing of the right ventricular outflow tract that can occur at the pulmonary valve (valvular stenosis), below the pulmonary valve (infundibular stenosis), or above the pulmonary valve (supravalvar stenosis). | 4 | 0.007569 | 13 |
| HP | HP:0002647 | Aortic dissection | Aortic dissection refers to a tear in the intimal layer of the aorta causing a separation between the intima and the medial layers of the aorta. | 3 | 0.008727 | 13 |
| HP | HP:0002138 | Subarachnoid hemorrhage | Hemorrhage occurring between the arachnoid mater and the pia mater. | 3 | 0.008727 | 13 |
| HP | HP:0025722 | Cerebral infarct | A necrotic lesion in the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors. | 3 | 0.009412 | 13 |
| HP | HP:0100323 | Juvenile aseptic necrosis | Juvenile aseptic necrosis comprises a group of orthopedic diseases characterized by interruption of the blood supply of a bone, followed by localized bony necrosis most often of the epiphyses of bones of children or teenagers. | 3 | 0.010886 | 13 |
| HP | HP:0002705 | High, narrow palate | The presence of a high and narrow palate. | 4 | 0.011696 | 13 |
| HP | HP:0031654 | Abnormal pulmonary valve physiology | Any functional anomaly of the pumonary valve. | 4 | 0.014294 | 13 |
| HP | HP:0001633 | Abnormal mitral valve morphology | Any structural anomaly of the mitral valve. | 4 | 0.014647 | 13 |
| HP | HP:0008419 | Intervertebral disk degeneration | The presence of degenerative changes of intervertebral disk. | 2 | 0.017063 | 13 |
| HP | HP:0004944 | Dilatation of the cerebral artery | The presence of a localized dilatation or ballooning of a cerebral artery. | 3 | 0.020573 | 13 |
| HP | HP:0001677 | Coronary artery atherosclerosis | Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries, which increases the risk of myocardial ischemia. | 3 | 0.020573 | 13 |
| HP | HP:0001646 | Abnormal aortic valve morphology | Any abnormality of the aortic valve. | 4 | 0.022168 | 13 |
| HP | HP:0031652 | Abnormal aortic valve physiology | Abnormal aortic valve physiology | 4 | 0.022168 | 13 |
| HP | HP:0010886 | Osteochondritis dissecans | A joint disorder caused by blood deprivation in the subchondral bone causing the subchondral bone to die in a process called avascular necrosis. The bone is then reabsorbed by the body, leaving the articular cartilage it supported prone to damage. The result is fragmentation (dissection) of both cartilage and bone, and the free movement of these osteochondral fragments within the joint space, causing pain and further damage. | 2 | 0.023876 | 13 |
| HP | HP:0006705 | Abnormal atrioventricular valve morphology | An abnormality of an atrioventricular valve. | 4 | 0.024688 | 13 |
| HP | HP:0010651 | Abnormal meningeal morphology | An abnormality of the Meninges, including any abnormality of the Dura mater, the Arachnoid mater, and the Pia mater. | 4 | 0.025217 | 13 |
| HP | HP:0002326 | Transient ischemic attack | Transient ischemic attack | 3 | 0.031494 | 13 |
| HP | HP:0006687 | Aortic tortuosity | Abnormal tortuous (i.e., twisted) form of the aorta. | 2 | 0.031818 | 13 |
| HP | HP:0000189 | Narrow palate | Width of the palate more than 2 SD below the mean (objective) or apparently decreased palatal width (subjective). | 4 | 0.034195 | 13 |
| HP | HP:0000766 | Abnormal sternum morphology | An anomaly of the sternum, also known as the breastbone. | 5 | 0.039672 | 13 |
| HP | HP:0100718 | Uterine rupture | Uterine rupture | 2 | 0.040887 | 13 |
| HP | HP:0002094 | Dyspnea | Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale. | 5 | 0.049024 | 13 |
| HP | HP:0002616 | Aortic root aneurysm | An abnormal localized widening (dilatation) of the aortic root. | 3 | 0.049791 | 13 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11716 | Factor: TGIF2; motif: NTGACANN | Factor: TGIF2; motif: NTGACANN | 7 | 0.005551 | 13 |
| TF | TF:M00469_1 | Factor: AP-2alpha; motif: GCCNNNRGS; match class: 1 | Factor: AP-2alpha; motif: GCCNNNRGS; match class: 1 | 8 | 0.030984 | 13 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 5 | 0.016533 | 13 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 5 | 0.019597 | 13 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 5 | 0.044419 | 13 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4756-3p | hsa-mir-4756-3p | hsa-mir-4756-3p | 6 | 0.021505 | 13 |
| MIRNA | MIRNA:hsa-mir-200b | hsa-mir-200b | hsa-mir-200b | 6 | 0.025822 | 13 |
| MIRNA | MIRNA:hsa-mir-200c | hsa-mir-200c | hsa-mir-200c | 6 | 0.025822 | 13 |
| MIRNA | MIRNA:hsa-mir-27a-3p | hsa-mir-27a-3p | hsa-mir-27a-3p | 4 | 0.033237 | 13 |
| MIRNA | MIRNA:hsa-mir-155-5p | hsa-mir-155-5p | hsa-mir-155-5p | 5 | 0.035936 | 13 |
Community 14
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0001533 | cornified envelope | "A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes)." [GOC:add, PMID:11112355, PMID:11590230, PMID:15803139] | 8 | 8.840390e-18 | 14 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 8 | 3.550197e-08 | 14 |
| GO:CC | GO:0030057 | desmosome | "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181] | 4 | 6.314579e-08 | 14 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 8 | 1.632148e-07 | 14 |
| GO:CC | GO:0070820 | tertiary granule | "A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] | 4 | 6.344503e-05 | 14 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 4 | 1.029868e-04 | 14 |
| GO:CC | GO:0036457 | keratohyalin granule | "A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope." [GOC:krc, PMID:15854042] | 2 | 1.217103e-04 | 14 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 8 | 1.249746e-04 | 14 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 8 | 1.272759e-04 | 14 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 5 | 1.872211e-04 | 14 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 9 | 2.020928e-04 | 14 |
| GO:CC | GO:0101003 | ficolin-1-rich granule membrane | "The lipid bilayer surrounding a ficolin-1-rich granule." [GOC:mec, PMID:23650620] | 3 | 2.474959e-04 | 14 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 9 | 3.259701e-04 | 14 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 7 | 7.246139e-04 | 14 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 7 | 7.968671e-04 | 14 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 7 | 7.993766e-04 | 14 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 7 | 7.993766e-04 | 14 |
| GO:CC | GO:0035578 | azurophil granule lumen | "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] | 3 | 8.721959e-04 | 14 |
| GO:CC | GO:0030667 | secretory granule membrane | "The lipid bilayer surrounding a secretory granule." [GOC:mah] | 4 | 9.160665e-04 | 14 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 8 | 9.361713e-04 | 14 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 4 | 9.622685e-04 | 14 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 4 | 1.022422e-03 | 14 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 4 | 1.034780e-03 | 14 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 5 | 2.745361e-03 | 14 |
| GO:CC | GO:0042582 | azurophil granule | "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule] | 3 | 4.304058e-03 | 14 |
| GO:CC | GO:0005766 | primary lysosome | "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] | 3 | 4.304058e-03 | 14 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 9 | 5.378564e-03 | 14 |
| GO:CC | GO:0005775 | vacuolar lumen | "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] | 3 | 6.718883e-03 | 14 |
| GO:CC | GO:0005912 | adherens junction | "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264] | 3 | 7.767526e-03 | 14 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 9 | 1.065653e-02 | 14 |
| GO:CC | GO:0030659 | cytoplasmic vesicle membrane | "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] | 5 | 1.256409e-02 | 14 |
| GO:CC | GO:0012506 | vesicle membrane | "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] | 5 | 1.349799e-02 | 14 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 8 | 1.760082e-02 | 14 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 6 | 2.543359e-02 | 14 |
| GO:CC | GO:0014704 | intercalated disc | "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910] | 2 | 2.762484e-02 | 14 |
| GO:CC | GO:0071665 | gamma-catenin-TCF7L2 complex | "A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:vk, PMID:14661054] | 1 | 4.994332e-02 | 14 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0461402 | Skin 1; cells in corneal layer[≥Medium] | Skin 1; cells in corneal layer[≥Medium] | 5 | 8.033405e-08 | 14 |
| HPA | HPA:0471402 | Skin 2; cells in corneal layer[≥Medium] | Skin 2; cells in corneal layer[≥Medium] | 5 | 4.594062e-07 | 14 |
| HPA | HPA:0461401 | Skin 1; cells in corneal layer[≥Low] | Skin 1; cells in corneal layer[≥Low] | 5 | 5.427640e-07 | 14 |
| HPA | HPA:0461403 | Skin 1; cells in corneal layer[High] | Skin 1; cells in corneal layer[High] | 4 | 9.547522e-07 | 14 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 7 | 3.096934e-06 | 14 |
| HPA | HPA:0471401 | Skin 2; cells in corneal layer[≥Low] | Skin 2; cells in corneal layer[≥Low] | 5 | 3.992726e-06 | 14 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 7 | 1.260018e-05 | 14 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 7 | 1.664094e-05 | 14 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 7 | 1.815409e-05 | 14 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 7 | 2.638165e-05 | 14 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 5 | 3.042379e-05 | 14 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 7 | 6.754444e-05 | 14 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 5 | 7.475660e-05 | 14 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 5 | 7.475660e-05 | 14 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 6 | 1.456399e-04 | 14 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 6 | 1.958310e-04 | 14 |
| HPA | HPA:0471403 | Skin 2; cells in corneal layer[High] | Skin 2; cells in corneal layer[High] | 3 | 3.042947e-04 | 14 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 4 | 3.316832e-03 | 14 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6798695 | Neutrophil degranulation | Neutrophil degranulation | 8 | 1.325850e-07 | 14 |
| REAC | REAC:R-HSA-6809371 | Formation of the cornified envelope | Formation of the cornified envelope | 5 | 1.353119e-05 | 14 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 8 | 1.001495e-04 | 14 |
| REAC | REAC:R-HSA-6805567 | Keratinization | Keratinization | 5 | 1.778261e-04 | 14 |
| REAC | REAC:R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | Apoptotic cleavage of cell adhesion proteins | 2 | 1.118270e-02 | 14 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 7 | 1.144242e-02 | 14 |
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 8 | 1.407300e-02 | 14 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011124 | Abnormal epidermal morphology | An abnormality of the morphology of the epidermis. | 5 | 0.000002 | 14 |
| HP | HP:0100792 | Acantholysis | The loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes. | 3 | 0.000054 | 14 |
| HP | HP:0025092 | Epidermal acanthosis | Diffuse hypertrophy or thickening of the stratum spinosum of the epidermis (prickle cell layer of the skin). | 4 | 0.000055 | 14 |
| HP | HP:0040162 | Orthokeratosis | Formation of an anuclear keratin layer | 3 | 0.000509 | 14 |
| HP | HP:0000982 | Palmoplantar keratoderma | Abnormal thickening of the skin of the palms of the hands and the soles of the feet. | 4 | 0.001041 | 14 |
| HP | HP:0008066 | Abnormal blistering of the skin | The presence of one or more bullae on the skin, defined as fluid-filled blisters more than 5 mm in diameter with thin walls. | 4 | 0.001201 | 14 |
| HP | HP:0000972 | Palmoplantar hyperkeratosis | Abnormal thickening of the skin localized to the palm of the hand and the sole of the foot. | 4 | 0.001792 | 14 |
| HP | HP:0010765 | Palmar hyperkeratosis | Abnormal thickening of the skin localized to the palm of the hand. | 4 | 0.001909 | 14 |
| HP | HP:0007556 | Plantar hyperkeratosis | Hyperkeratosis affecting the sole of the foot. | 4 | 0.001969 | 14 |
| HP | HP:0011368 | Epidermal thickening | Thickening of the epidermal layer of the skin. | 5 | 0.002125 | 14 |
| HP | HP:0005597 | Congenital alopecia totalis | Loss of all scalp hair with congenital onset. | 2 | 0.002279 | 14 |
| HP | HP:0008404 | Nail dystrophy | Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate. | 4 | 0.002889 | 14 |
| HP | HP:0001072 | Thickened skin | Laminar thickening of skin. | 5 | 0.003979 | 14 |
| HP | HP:0100872 | Abnormality of the plantar skin of foot | An abnormality of the plantar part of foot, that is of the soles of the feet. | 4 | 0.005649 | 14 |
| HP | HP:0040189 | Scaling skin | Refers to the loss of the outer layer of the epidermis in large, scale-like flakes. | 3 | 0.007186 | 14 |
| HP | HP:0031274 | Hypovolemic shock | A state of shock characterized by decreased circulating blood volume in relation to total vascular capacity. This type of shock is characterized by a reduction of diastolic filling pressures. | 2 | 0.007591 | 14 |
| HP | HP:0010705 | 4-5 finger cutaneous syndactyly | A soft tissue continuity in the anteroposterior axis between the fourth (ring) to the fifth (little) finger that extends distally to at least the level of the proximal interphalangeal joints. | 2 | 0.007591 | 14 |
| HP | HP:0006097 | 3-4 finger osseus syndactyly | Fusion of the third (middle) and fourth (ring) finger, involving soft parts and including fusion of individual finger bones. | 2 | 0.007591 | 14 |
| HP | HP:0010492 | Osseous finger syndactyly | Webbing or fusion of the fingers, involving soft parts and including fusion of individual finger bones. | 2 | 0.011381 | 14 |
| HP | HP:0011663 | Right ventricular cardiomyopathy | Right ventricular dysfunction (global or regional) with functional and morphological right ventricular abnormalities, with or without left ventricular disease. | 2 | 0.015928 | 14 |
| HP | HP:0000962 | Hyperkeratosis | Hyperkeratosis is thickening of the epidermis involving the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum. | 4 | 0.019711 | 14 |
| HP | HP:0006670 | Impaired myocardial contractility | Impaired myocardial contractility | 2 | 0.034090 | 14 |
| HP | HP:0001233 | 2-3 finger cutaneous syndactyly | A soft tissue continuity in the anteroposterior axis between the second to the third fingers that extends distally to at least the level of the proximal interphalangeal joints. | 2 | 0.041650 | 14 |
| HP | HP:0032449 | Abnormal dermoepidermal hemidesmosome morphology | An abnormal structure or appearance of hemidesmosomes, multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane. | 2 | 0.041650 | 14 |
| HP | HP:0031538 | Abnormal dermoepidermal junction morphology | Any anomaly of the structure of the acellular zone that is between the dermis and the epidermis and which functions to bind the epidermis to the dermis and to serve as a selective barrier allowing the control of molecular and cellular exchanges between the two compartments. | 2 | 0.049960 | 14 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043588 | skin development | "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] | 5 | 0.000117 | 14 |
| GO:BP | GO:0008544 | epidermis development | "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] | 5 | 0.000312 | 14 |
| GO:BP | GO:0007155 | cell adhesion | "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] | 7 | 0.000374 | 14 |
| GO:BP | GO:0098609 | cell-cell adhesion | "The attachment of one cell to another cell via adhesion molecules." [GOC:dos] | 6 | 0.000815 | 14 |
| GO:BP | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication | "The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 2 | 0.002712 | 14 |
| GO:BP | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion | "The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 2 | 0.003796 | 14 |
| GO:BP | GO:0002934 | desmosome organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd] | 2 | 0.009933 | 14 |
| GO:BP | GO:0098911 | regulation of ventricular cardiac muscle cell action potential | "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 2 | 0.011917 | 14 |
| GO:BP | GO:0086069 | bundle of His cell to Purkinje myocyte communication | "The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 2 | 0.018947 | 14 |
| GO:BP | GO:0090136 | epithelial cell-cell adhesion | "The attachment of an epithelial cell to another epithelial cell via adhesion molecules." [GOC:ascb_2009, GOC:dph, GOC:tb] | 2 | 0.024530 | 14 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0098632 | cell-cell adhesion mediator activity | "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion] | 3 | 0.000383 | 14 |
| GO:MF | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication | "Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 2 | 0.000396 | 14 |
| GO:MF | GO:0098631 | cell adhesion mediator activity | "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell." [GOC:vw, Wikipedia:Cell_adhesion] | 3 | 0.000843 | 14 |
| GO:MF | GO:0005509 | calcium ion binding | "Binding to a calcium ion (Ca2+)." [GOC:ai] | 5 | 0.002336 | 14 |
| GO:MF | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion | "Binding to a protein or protein complex contributing to the adhesion of two different types of cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 2 | 0.003083 | 14 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | Arrhythmogenic right ventricular cardiomyopathy | 2 | 0.046576 | 14 |
Community 15
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 2 | 0.000080 | 15 |
| REAC | REAC:R-HSA-202733 | Cell surface interactions at the vascular wall | Cell surface interactions at the vascular wall | 4 | 0.000695 | 15 |
| REAC | REAC:R-HSA-433692 | Proton-coupled monocarboxylate transport | Proton-coupled monocarboxylate transport | 2 | 0.001197 | 15 |
| REAC | REAC:R-HSA-9027284 | Erythropoietin activates RAS | Erythropoietin activates RAS | 2 | 0.005259 | 15 |
| REAC | REAC:R-HSA-9669938 | Signaling by KIT in disease | Signaling by KIT in disease | 2 | 0.010821 | 15 |
| REAC | REAC:R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | 2 | 0.010821 | 15 |
| REAC | REAC:R-HSA-5621575 | CD209 (DC-SIGN) signaling | CD209 (DC-SIGN) signaling | 2 | 0.015104 | 15 |
| REAC | REAC:R-HSA-9006335 | Signaling by Erythropoietin | Signaling by Erythropoietin | 2 | 0.020093 | 15 |
| REAC | REAC:R-HSA-210991 | Basigin interactions | Basigin interactions | 2 | 0.023812 | 15 |
| REAC | REAC:R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | Signaling by Receptor Tyrosine Kinases | 4 | 0.034418 | 15 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003925 | G protein activity | "A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015] | 3 | 0.000119 | 15 |
| GO:MF | GO:0019003 | GDP binding | "Binding to GDP, guanosine 5'-diphosphate." [GOC:ai] | 3 | 0.028642 | 15 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 6 | 0.002430 | 15 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 6 | 0.002639 | 15 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 6 | 0.002646 | 15 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 6 | 0.002646 | 15 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 8 | 0.003332 | 15 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 6 | 0.005138 | 15 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 8 | 0.006260 | 15 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 5 | 0.015221 | 15 |
| GO:CC | GO:0030139 | endocytic vesicle | "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797] | 3 | 0.028770 | 15 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 6 | 0.032935 | 15 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | Fc gamma R-mediated phagocytosis | 3 | 0.004216 | 15 |
| KEGG | KEGG:04148 | Efferocytosis | Efferocytosis | 3 | 0.017829 | 15 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4301 | Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells | Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells | 2 | 0.009881 | 15 |
| WP | WP:WP481 | Insulin signaling | Insulin signaling | 3 | 0.023562 | 15 |
| WP | WP:WP4223 | Ras signaling | Ras signaling | 3 | 0.035057 | 15 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043434 | response to peptide hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] | 4 | 0.012905 | 15 |
| GO:BP | GO:0070201 | regulation of establishment of protein localization | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] | 4 | 0.028275 | 15 |
| GO:BP | GO:0030335 | positive regulation of cell migration | "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators] | 4 | 0.033103 | 15 |
| GO:BP | GO:1903530 | regulation of secretion by cell | "Any process that modulates the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] | 4 | 0.034042 | 15 |
| GO:BP | GO:2000147 | positive regulation of cell motility | "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah] | 4 | 0.040097 | 15 |
| GO:BP | GO:0040017 | positive regulation of locomotion | "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] | 4 | 0.044552 | 15 |
| GO:BP | GO:0051046 | regulation of secretion | "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] | 4 | 0.048740 | 15 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2910 | PLC-gamma-2-Lyn-FcR-gamma complex | PLC-gamma-2-Lyn-FcR-gamma complex | 1 | 0.04968 | 15 |
Community 16
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005852 | eukaryotic translation initiation factor 3 complex | "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] | 5 | 3.255815e-13 | 16 |
| GO:CC | GO:0033290 | eukaryotic 48S preinitiation complex | "The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC." [GOC:hjd, PMID:16510876, PMID:24319994, PMID:24499181, PMID:29735639] | 5 | 4.612058e-13 | 16 |
| GO:CC | GO:0016282 | eukaryotic 43S preinitiation complex | "A protein complex composed of the 40S ribosomal subunit plus eIF1, eIF1A, eIF3, eIF5, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049, PMID:16510876, PMID:25742741, PMID:29735639] | 5 | 6.385445e-13 | 16 |
| GO:CC | GO:0070993 | cytosolic translation preinitiation complex | "A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA." [GOC:hjd, GOC:mah] | 5 | 8.665309e-13 | 16 |
| GO:CC | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m | "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185] | 2 | 2.833765e-04 | 16 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0001732 | formation of cytoplasmic translation initiation complex | "Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd, PMID:29735639] | 5 | 2.677488e-12 | 16 |
| GO:BP | GO:0002183 | cytoplasmic translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] | 5 | 8.382439e-10 | 16 |
| GO:BP | GO:0006413 | translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] | 5 | 1.544695e-07 | 16 |
| GO:BP | GO:0002181 | cytoplasmic translation | "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] | 5 | 5.807274e-07 | 16 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 6 | 1.137971e-05 | 16 |
| GO:BP | GO:1902415 | regulation of mRNA binding | "Any process that modulates the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846] | 2 | 5.698626e-04 | 16 |
| GO:BP | GO:1902416 | positive regulation of mRNA binding | "Any process that activates or increases the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846] | 2 | 5.698626e-04 | 16 |
| GO:BP | GO:1905216 | positive regulation of RNA binding | "Any process that activates or increases the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364] | 2 | 9.496204e-04 | 16 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 4 | 3.520908e-03 | 16 |
| GO:BP | GO:0022618 | protein-RNA complex assembly | "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] | 5 | 4.424947e-02 | 16 |
| GO:BP | GO:0071826 | protein-RNA complex organization | "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah] | 5 | 4.562907e-02 | 16 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5027 | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell | 5 | 2.537405e-11 | 16 |
| WP | WP:WP107 | Translation factors | Translation factors | 5 | 1.222835e-08 | 16 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003743 | translation initiation factor activity | "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] | 5 | 3.061462e-10 | 16 |
| GO:MF | GO:0180051 | translation factor activity | "A molecular function required for translation of a mRNA into a protein functioning as part of initiation, elongation or termination of translation." [GOC:pg] | 5 | 4.945687e-09 | 16 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:742 | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) | 5 | 5.174631e-10 | 16 |
| CORUM | CORUM:1097 | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) | 5 | 8.404620e-10 | 16 |
| CORUM | CORUM:4399 | EIF3 complex (EIF3B, EIF3J, EIF3I) | EIF3 complex (EIF3B, EIF3J, EIF3I) | 2 | 1.264583e-03 | 16 |
| CORUM | CORUM:4392 | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) | 2 | 4.206968e-03 | 16 |
| CORUM | CORUM:4403 | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J) | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J) | 2 | 4.206968e-03 | 16 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Formation of the ternary complex, and subsequently, the 43S complex | 5 | 2.605204e-09 | 16 |
| REAC | REAC:R-HSA-72649 | Translation initiation complex formation | Translation initiation complex formation | 5 | 5.015742e-09 | 16 |
| REAC | REAC:R-HSA-72702 | Ribosomal scanning and start codon recognition | Ribosomal scanning and start codon recognition | 5 | 5.015742e-09 | 16 |
| REAC | REAC:R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 5 | 5.471303e-09 | 16 |
| REAC | REAC:R-HSA-72689 | Formation of a pool of free 40S subunits | Formation of a pool of free 40S subunits | 5 | 8.317435e-08 | 16 |
| REAC | REAC:R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | L13a-mediated translational silencing of Ceruloplasmin expression | 5 | 1.338625e-07 | 16 |
| REAC | REAC:R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | GTP hydrolysis and joining of the 60S ribosomal subunit | 5 | 1.400491e-07 | 16 |
| REAC | REAC:R-HSA-72737 | Cap-dependent Translation Initiation | Cap-dependent Translation Initiation | 5 | 1.900481e-07 | 16 |
| REAC | REAC:R-HSA-72613 | Eukaryotic Translation Initiation | Eukaryotic Translation Initiation | 5 | 1.900481e-07 | 16 |
| REAC | REAC:R-HSA-72766 | Translation | Translation | 5 | 1.682002e-05 | 16 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 6 | 9.750004e-03 | 16 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 7 | 0.000164 | 16 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 6 | 0.003376 | 16 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 7 | 0.005386 | 16 |
| HPA | HPA:0460652 | Skin 1; fibroblasts[≥Medium] | Skin 1; fibroblasts[≥Medium] | 7 | 0.007272 | 16 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 7 | 0.010432 | 16 |
| HPA | HPA:0470683 | Skin 2; epidermal cells[High] | Skin 2; epidermal cells[High] | 5 | 0.013370 | 16 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 5 | 0.021102 | 16 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 5 | 0.028687 | 16 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05162 | Measles | Measles | 2 | 0.038597 | 16 |
Community 17
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 7 | 3.324355e-18 | 17 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 8 | 1.478166e-17 | 17 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 8 | 1.478166e-17 | 17 |
| REAC | REAC:R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | Transcription of E2F targets under negative control by DREAM complex | 7 | 1.643652e-17 | 17 |
| REAC | REAC:R-HSA-1538133 | G0 and Early G1 | G0 and Early G1 | 7 | 3.395254e-16 | 17 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 7 | 4.583227e-16 | 17 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 8 | 2.213842e-13 | 17 |
| REAC | REAC:R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | TP53 Regulates Transcription of Cell Cycle Genes | 6 | 3.948472e-11 | 17 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 7 | 5.712120e-11 | 17 |
| REAC | REAC:R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 5 | 8.903210e-11 | 17 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 6 | 9.836214e-10 | 17 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 6 | 1.141468e-09 | 17 |
| REAC | REAC:R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 5 | 3.901391e-09 | 17 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 8 | 9.140460e-09 | 17 |
| REAC | REAC:R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5 | 2.185664e-08 | 17 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 8 | 5.053864e-08 | 17 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 6 | 6.341285e-08 | 17 |
| REAC | REAC:R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 4 | 6.795438e-08 | 17 |
| REAC | REAC:R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 4 | 6.795438e-08 | 17 |
| REAC | REAC:R-HSA-170834 | Signaling by TGF-beta Receptor Complex | Signaling by TGF-beta Receptor Complex | 5 | 5.024569e-07 | 17 |
| REAC | REAC:R-HSA-111448 | Activation of NOXA and translocation to mitochondria | Activation of NOXA and translocation to mitochondria | 3 | 6.301585e-07 | 17 |
| REAC | REAC:R-HSA-2559585 | Oncogene Induced Senescence | Oncogene Induced Senescence | 4 | 1.162925e-06 | 17 |
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4 | 1.672586e-06 | 17 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 4 | 2.094728e-06 | 17 |
| REAC | REAC:R-HSA-9006936 | Signaling by TGFB family members | Signaling by TGFB family members | 5 | 2.103422e-06 | 17 |
| REAC | REAC:R-HSA-139915 | Activation of PUMA and translocation to mitochondria | Activation of PUMA and translocation to mitochondria | 3 | 5.286116e-06 | 17 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 6 | 7.664594e-06 | 17 |
| REAC | REAC:R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 3 | 2.286747e-05 | 17 |
| REAC | REAC:R-HSA-1912408 | Pre-NOTCH Transcription and Translation | Pre-NOTCH Transcription and Translation | 4 | 7.805197e-05 | 17 |
| REAC | REAC:R-HSA-113510 | E2F mediated regulation of DNA replication | E2F mediated regulation of DNA replication | 3 | 1.109179e-04 | 17 |
| REAC | REAC:R-HSA-1912422 | Pre-NOTCH Expression and Processing | Pre-NOTCH Expression and Processing | 4 | 1.490015e-04 | 17 |
| REAC | REAC:R-HSA-2559580 | Oxidative Stress Induced Senescence | Oxidative Stress Induced Senescence | 4 | 2.432092e-04 | 17 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 3 | 2.536714e-04 | 17 |
| REAC | REAC:R-HSA-8953750 | Transcriptional Regulation by E2F6 | Transcriptional Regulation by E2F6 | 3 | 3.733740e-04 | 17 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 7 | 3.964537e-04 | 17 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 7 | 7.560754e-04 | 17 |
| REAC | REAC:R-HSA-68911 | G2 Phase | G2 Phase | 2 | 1.155028e-03 | 17 |
| REAC | REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | Intrinsic Pathway for Apoptosis | 3 | 1.537117e-03 | 17 |
| REAC | REAC:R-HSA-2559583 | Cellular Senescence | Cellular Senescence | 4 | 1.551003e-03 | 17 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 7 | 1.652958e-03 | 17 |
| REAC | REAC:R-HSA-157118 | Signaling by NOTCH | Signaling by NOTCH | 4 | 3.099499e-03 | 17 |
| REAC | REAC:R-HSA-9616222 | Transcriptional regulation of granulopoiesis | Transcriptional regulation of granulopoiesis | 3 | 6.494832e-03 | 17 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP179 | Cell cycle | Cell cycle | 8 | 1.295721e-13 | 17 |
| WP | WP:WP5180 | DYRK1A involvement regarding cell proliferation in brain development | DYRK1A involvement regarding cell proliferation in brain development | 6 | 3.585512e-10 | 17 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 4 | 2.337209e-05 | 17 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 4 | 8.899191e-05 | 17 |
| WP | WP:WP236 | Adipogenesis | Adipogenesis | 4 | 4.077906e-04 | 17 |
| WP | WP:WP53 | ID signaling | ID signaling | 2 | 1.144112e-02 | 17 |
| WP | WP:WP5202 | Alstrom syndrome | Alstrom syndrome | 2 | 4.694506e-02 | 17 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 8 | 6.430657e-13 | 17 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 6 | 5.125568e-08 | 17 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | TGF-beta signaling pathway | 4 | 8.997195e-05 | 17 |
| KEGG | KEGG:05219 | Bladder cancer | Bladder cancer | 2 | 3.499491e-02 | 17 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 8 | 1.266567e-11 | 17 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 6 | 8.530051e-09 | 17 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 8 | 3.533766e-08 | 17 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 8 | 6.051591e-07 | 17 |
| GO:CC | GO:0035189 | Rb-E2F complex | "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073] | 2 | 9.457039e-05 | 17 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 8 | 2.548675e-04 | 17 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 8 | 2.107947e-03 | 17 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 8 | 9.303346e-03 | 17 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 8 | 9.314518e-03 | 17 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 8 | 9.597656e-03 | 17 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 8 | 9.597656e-03 | 17 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 8 | 9.597656e-03 | 17 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 6 | 9.667260e-03 | 17 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 8 | 3.819503e-02 | 17 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2975 | SMAD3-E2F4/5-p107-DP1 complex | SMAD3-E2F4/5-p107-DP1 complex | 4 | 3.865266e-10 | 17 |
| CORUM | CORUM:1474 | SMAD3/4-E2F4/5-p107-DP1 complex | SMAD3/4-E2F4/5-p107-DP1 complex | 4 | 1.159030e-09 | 17 |
| CORUM | CORUM:1473 | E2F5-RB2-DP1 complex | E2F5-RB2-DP1 complex | 3 | 8.713858e-08 | 17 |
| CORUM | CORUM:5117 | RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2) | RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2) | 3 | 8.702259e-07 | 17 |
| CORUM | CORUM:5118 | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) | 3 | 1.739293e-06 | 17 |
| CORUM | CORUM:5160 | E2F4-p130 complex | E2F4-p130 complex | 2 | 7.365388e-05 | 17 |
| CORUM | CORUM:6588 | E2F-1-DP-1 complex | E2F-1-DP-1 complex | 2 | 7.365388e-05 | 17 |
| CORUM | CORUM:5159 | E2F4-p107-cyclinE complex | E2F4-p107-cyclinE complex | 2 | 7.365388e-05 | 17 |
| CORUM | CORUM:3900 | GABP(gamma)1-E2F1-DP1 complex | GABP(gamma)1-E2F1-DP1 complex | 2 | 2.207874e-04 | 17 |
| CORUM | CORUM:5144 | E2F1-p107-cyclinA complex | E2F1-p107-cyclinA complex | 2 | 2.207874e-04 | 17 |
| CORUM | CORUM:1661 | E2F4-p107-cyclinA complex | E2F4-p107-cyclinA complex | 2 | 2.207874e-04 | 17 |
| CORUM | CORUM:6589 | E2F-1-DP-1-cyclinA-CDK2 complex | E2F-1-DP-1-cyclinA-CDK2 complex | 2 | 2.207874e-04 | 17 |
| CORUM | CORUM:1471 | pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300) | pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300) | 2 | 7.347972e-04 | 17 |
| CORUM | CORUM:6444 | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex | 2 | 1.101326e-03 | 17 |
| CORUM | CORUM:5596 | LINC complex, quiescent cells | LINC complex, quiescent cells | 2 | 1.101326e-03 | 17 |
| CORUM | CORUM:5614 | Emerin complex 32 | Emerin complex 32 | 2 | 1.379668e-02 | 17 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] | 8 | 6.365225e-08 | 17 |
| GO:MF | GO:0000976 | transcription cis-regulatory region binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] | 8 | 1.100511e-07 | 17 |
| GO:MF | GO:0001067 | transcription regulatory region nucleic acid binding | "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] | 8 | 1.106468e-07 | 17 |
| GO:MF | GO:1990837 | sequence-specific double-stranded DNA binding | "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] | 8 | 1.527687e-07 | 17 |
| GO:MF | GO:0003690 | double-stranded DNA binding | "Binding to double-stranded DNA." [GOC:elh, GOC:vw] | 8 | 2.487664e-07 | 17 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 8 | 2.649815e-07 | 17 |
| GO:MF | GO:0001216 | DNA-binding transcription activator activity | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018] | 6 | 6.669155e-07 | 17 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 8 | 8.177135e-06 | 17 |
| GO:MF | GO:1990841 | promoter-specific chromatin binding | "Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729] | 3 | 2.680565e-04 | 17 |
| GO:MF | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018] | 6 | 3.024975e-04 | 17 |
| GO:MF | GO:0003700 | DNA-binding transcription factor activity | "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] | 6 | 4.374775e-04 | 17 |
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 6 | 2.529536e-03 | 17 |
| GO:MF | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] | 4 | 2.685178e-03 | 17 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 8 | 3.581489e-03 | 17 |
| GO:MF | GO:0000987 | cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018] | 5 | 4.785910e-03 | 17 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0070345 | negative regulation of fat cell proliferation | "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] | 3 | 3.764481e-07 | 17 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 5 | 4.438361e-06 | 17 |
| GO:BP | GO:0070344 | regulation of fat cell proliferation | "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] | 3 | 4.513349e-06 | 17 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 5 | 8.517294e-06 | 17 |
| GO:BP | GO:0070341 | fat cell proliferation | "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl] | 3 | 1.709785e-05 | 17 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 8 | 5.269819e-05 | 17 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 8 | 7.884976e-05 | 17 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 4 | 1.774617e-04 | 17 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 5 | 1.893881e-04 | 17 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 4 | 3.370281e-04 | 17 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 8 | 4.939696e-04 | 17 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 8 | 5.164526e-04 | 17 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 5 | 5.574675e-04 | 17 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 8 | 6.818253e-04 | 17 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 8 | 9.254194e-04 | 17 |
| GO:BP | GO:0043550 | regulation of lipid kinase activity | "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf] | 2 | 1.318792e-03 | 17 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 8 | 1.741757e-03 | 17 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 5 | 2.941168e-03 | 17 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 3.987015e-03 | 17 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 6 | 6.156996e-03 | 17 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 6 | 6.932577e-03 | 17 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 6 | 6.980596e-03 | 17 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 5 | 7.123550e-03 | 17 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 6 | 1.095602e-02 | 17 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 1.146442e-02 | 17 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 5 | 1.872579e-02 | 17 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 8 | 1.935116e-02 | 17 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 2.004233e-02 | 17 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 6 | 2.009748e-02 | 17 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 8 | 2.396762e-02 | 17 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 8 | 2.797657e-02 | 17 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 8 | 3.523471e-02 | 17 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 5 | 3.781411e-02 | 17 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 5 | 4.144953e-02 | 17 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-136 | hsa-mir-136 | hsa-mir-136 | 5 | 0.014320 | 17 |
| MIRNA | MIRNA:hsa-mir-20a-5p | hsa-mir-20a-5p | hsa-mir-20a-5p | 5 | 0.017066 | 17 |
| MIRNA | MIRNA:hsa-mir-106b-5p | hsa-mir-106b-5p | hsa-mir-106b-5p | 5 | 0.019205 | 17 |
| MIRNA | MIRNA:hsa-mir-17-5p | hsa-mir-17-5p | hsa-mir-17-5p | 5 | 0.027261 | 17 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 4 | 0.037891 | 17 |
Community 18
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005789 | endoplasmic reticulum membrane | "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] | 8 | 1.246809e-08 | 18 |
| GO:CC | GO:0098827 | endoplasmic reticulum subcompartment | "A distinct region of the endoplasmic reticulum." [GOC:dos] | 8 | 1.296324e-08 | 18 |
| GO:CC | GO:0042175 | nuclear outer membrane-endoplasmic reticulum membrane network | "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] | 8 | 1.464661e-08 | 18 |
| GO:CC | GO:0031984 | organelle subcompartment | "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] | 8 | 8.310521e-08 | 18 |
| GO:CC | GO:0005783 | endoplasmic reticulum | "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] | 8 | 8.742555e-07 | 18 |
| GO:CC | GO:0031090 | organelle membrane | "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] | 8 | 1.125302e-04 | 18 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 8 | 7.535959e-04 | 18 |
| GO:CC | GO:0098553 | lumenal side of endoplasmic reticulum membrane | "The side (leaflet) of the plasma membrane that faces the lumen." [GOC:ab, GOC:dos] | 2 | 7.293542e-03 | 18 |
| GO:CC | GO:0098576 | lumenal side of membrane | "Any side (leaflet) of a membrane that faces the lumen of an organelle." [GOC:dos] | 2 | 1.283851e-02 | 18 |
| GO:CC | GO:0005791 | rough endoplasmic reticulum | "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] | 2 | 2.854842e-02 | 18 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 3 | 0.014237 | 18 |
| HPA | HPA:0471422 | Skin 2; eccrine glands[≥Medium] | Skin 2; eccrine glands[≥Medium] | 2 | 0.018284 | 18 |
| HPA | HPA:0471421 | Skin 2; eccrine glands[≥Low] | Skin 2; eccrine glands[≥Low] | 2 | 0.027955 | 18 |
| HPA | HPA:0090923 | Cerebellum; GLUC cells - cytoplasm/membrane[High] | Cerebellum; GLUC cells - cytoplasm/membrane[High] | 2 | 0.039645 | 18 |
| HPA | HPA:0091073 | Cerebellum; white matter cells - cytoplasm/membrane[High] | Cerebellum; white matter cells - cytoplasm/membrane[High] | 2 | 0.049938 | 18 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 2 | 0.032186 | 18 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP183 | Proteasome degradation | Proteasome degradation | 2 | 0.046833 | 18 |
Community 19
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 3 | 3.753502e-07 | 19 |
| REAC | REAC:R-HSA-156711 | Polo-like kinase mediated events | Polo-like kinase mediated events | 3 | 3.753502e-07 | 19 |
| REAC | REAC:R-HSA-1538133 | G0 and Early G1 | G0 and Early G1 | 3 | 2.144858e-06 | 19 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 3 | 4.367229e-04 | 19 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 3 | 1.019451e-03 | 19 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 3 | 1.051142e-03 | 19 |
| REAC | REAC:R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | Transcription of E2F targets under negative control by DREAM complex | 2 | 1.387289e-03 | 19 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 2 | 3.180868e-03 | 19 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 3 | 2.262634e-02 | 19 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 2 | 2.999545e-02 | 19 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 2 | 3.148190e-02 | 19 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 3 | 4.285112e-02 | 19 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0031523 | Myb complex | "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624] | 2 | 0.000041 | 19 |
| GO:CC | GO:0033186 | CAF-1 complex | "A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276] | 2 | 0.000041 | 19 |
| GO:CC | GO:0017053 | transcription repressor complex | "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] | 2 | 0.041127 | 19 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2234 | Chromatin assembly complex (CAF-1 complex) | Chromatin assembly complex (CAF-1 complex) | 2 | 0.000132 | 19 |
| CORUM | CORUM:1259 | Chromatin assembly complex (CAF-1 complex) | Chromatin assembly complex (CAF-1 complex) | 2 | 0.000132 | 19 |
| CORUM | CORUM:5593 | LINC core complex | LINC core complex | 2 | 0.000264 | 19 |
| CORUM | CORUM:2235 | ASF1-interacting protein complex | ASF1-interacting protein complex | 2 | 0.000440 | 19 |
| CORUM | CORUM:5589 | LINC complex, S-phase | LINC complex, S-phase | 2 | 0.000440 | 19 |
| CORUM | CORUM:5596 | LINC complex, quiescent cells | LINC complex, quiescent cells | 2 | 0.000660 | 19 |
| CORUM | CORUM:1149 | Histone H3.1 complex | Histone H3.1 complex | 2 | 0.001231 | 19 |
| CORUM | CORUM:839 | LIN9-BMYB complex | LIN9-BMYB complex | 1 | 0.049680 | 19 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006335 | DNA replication-dependent chromatin assembly | "The formation of nucleosomes on newly synthesized DNA, coupled to strand elongation." [GOC:mah, PMID:28053344] | 2 | 0.001424 | 19 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 5 | 0.004787 | 19 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 3 | 0.002854 | 19 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2361 | Gastric cancer network 1 | Gastric cancer network 1 | 2 | 0.009435 | 19 |
| WP | WP:WP5180 | DYRK1A involvement regarding cell proliferation in brain development | DYRK1A involvement regarding cell proliferation in brain development | 2 | 0.046833 | 19 |
Community 20
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0043531 | ADP binding | "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl] | 2 | 0.016866 | 20 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 4 | 0.040119 | 20 |
Community 21
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00480 | Glutathione metabolism | Glutathione metabolism | 3 | 0.000058 | 21 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016491 | oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-] | 5 | 0.000072 | 21 |
| GO:MF | GO:0004602 | glutathione peroxidase activity | "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9, PMID:36771108] | 2 | 0.002839 | 21 |
| GO:MF | GO:0004601 | peroxidase activity | "Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators] | 2 | 0.019524 | 21 |
| GO:MF | GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor | "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [EC:1.11.-.-] | 2 | 0.020925 | 21 |
| GO:MF | GO:0016209 | antioxidant activity | "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] | 2 | 0.043510 | 21 |
| GO:MF | GO:0005254 | chloride channel activity | "Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] | 2 | 0.048780 | 21 |
| GO:MF | GO:0035731 | dinitrosyl-iron complex binding | "Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO." [GOC:BHF, PMID:10534443] | 1 | 0.049891 | 21 |
| GO:MF | GO:0035730 | S-nitrosoglutathione binding | "Binding to S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems." [GOC:BHF] | 1 | 0.049891 | 21 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 5 | 0.004101 | 21 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 5 | 0.007982 | 21 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 5 | 0.008555 | 21 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 5 | 0.008575 | 21 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 5 | 0.008575 | 21 |
| GO:CC | GO:0034707 | chloride channel complex | "An ion channel complex through which chloride ions pass." [GOC:mah] | 2 | 0.016649 | 21 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-3299685 | Detoxification of Reactive Oxygen Species | Detoxification of Reactive Oxygen Species | 2 | 0.009955 | 21 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0400241 | Rectum; peripheral nerve/ganglion[≥Low] | Rectum; peripheral nerve/ganglion[≥Low] | 3 | 0.02271 | 21 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043407 | negative regulation of MAP kinase activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] | 2 | 0.047034 | 21 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6948 | Isocitrate dehydrogenase [NADP], mitochondrial | Isocitrate dehydrogenase [NADP], mitochondrial | 1 | 0.049932 | 21 |
Community 22
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0044790 | suppression of viral release by host | "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl, PMID:18305167] | 2 | 0.004876 | 22 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-203a-5p | hsa-mir-203a-5p | hsa-mir-203a-5p | 2 | 0.038712 | 22 |
Community 23
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016421 | CoA carboxylase activity | "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah] | 2 | 0.000148 | 23 |
| GO:MF | GO:0016885 | ligase activity, forming carbon-carbon bonds | "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4.-.-] | 2 | 0.000207 | 23 |
| GO:MF | GO:0004075 | biotin carboxylase activity | "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] | 1 | 0.049992 | 23 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5031 | Biotin metabolism including IMDs | Biotin metabolism including IMDs | 2 | 0.000476 | 23 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | Defective HLCS causes multiple carboxylase deficiency | 2 | 0.000688 | 23 |
| REAC | REAC:R-HSA-3323169 | Defects in biotin (Btn) metabolism | Defects in biotin (Btn) metabolism | 2 | 0.000917 | 23 |
| REAC | REAC:R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | COPI-dependent Golgi-to-ER retrograde traffic | 3 | 0.001383 | 23 |
| REAC | REAC:R-HSA-6807878 | COPI-mediated anterograde transport | COPI-mediated anterograde transport | 3 | 0.001514 | 23 |
| REAC | REAC:R-HSA-196780 | Biotin transport and metabolism | Biotin transport and metabolism | 2 | 0.001800 | 23 |
| REAC | REAC:R-HSA-8856688 | Golgi-to-ER retrograde transport | Golgi-to-ER retrograde transport | 3 | 0.003365 | 23 |
| REAC | REAC:R-HSA-199977 | ER to Golgi Anterograde Transport | ER to Golgi Anterograde Transport | 3 | 0.005328 | 23 |
| REAC | REAC:R-HSA-3296482 | Defects in vitamin and cofactor metabolism | Defects in vitamin and cofactor metabolism | 2 | 0.007543 | 23 |
| REAC | REAC:R-HSA-948021 | Transport to the Golgi and subsequent modification | Transport to the Golgi and subsequent modification | 3 | 0.009197 | 23 |
| REAC | REAC:R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | Intra-Golgi and retrograde Golgi-to-ER traffic | 3 | 0.011769 | 23 |
| REAC | REAC:R-HSA-446203 | Asparagine N-linked glycosylation | Asparagine N-linked glycosylation | 3 | 0.040142 | 23 |
Community 24
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3965 | Lipid metabolism pathway | Lipid metabolism pathway | 2 | 0.010132 | 24 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045214 | sarcomere organization | "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] | 2 | 0.045567 | 24 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0100008 | Schwannoma | A benign nerve sheath tumor composed of Schwann cells. | 2 | 0.047936 | 24 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004013 | adenosylhomocysteinase activity | "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [RHEA:21708] | 1 | 0.049992 | 24 |
| GO:MF | GO:0004312 | fatty acid synthase activity | "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85] | 1 | 0.049992 | 24 |
| GO:MF | GO:0004313 | [acyl-carrier-protein] S-acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [RHEA:41788] | 1 | 0.049992 | 24 |
| GO:MF | GO:0008681 | 2-octaprenyl-6-methoxyphenol hydroxylase activity | "Catalysis of the reaction: 2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP+." [PMID:27822549, PMID:4572721, RHEA:29407] | 1 | 0.049992 | 24 |
| GO:MF | GO:0031177 | phosphopantetheine binding | "Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [GOC:mah, GOC:vw] | 1 | 0.049992 | 24 |
| GO:MF | GO:0046508 | hydrolase activity, acting on carbon-sulfur bonds | "Catalysis of the hydrolysis of any carbon-sulfur bond, C-S." [GOC:jl] | 1 | 0.049992 | 24 |
| GO:MF | GO:0106364 | 4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity | "Catalysis of the reaction: 4-hydroxy-3-all-trans-polyprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]." [PMID:38425362, RHEA:81195] | 1 | 0.049992 | 24 |
Community 25
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 4 | 0.000363 | 25 |
| GO:CC | GO:0005884 | actin filament | "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] | 3 | 0.000367 | 25 |
| GO:CC | GO:0031252 | cell leading edge | "The area of a motile cell closest to the direction of movement." [GOC:pg] | 3 | 0.015943 | 25 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 4 | 0.005532 | 25 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 4 | 0.009048 | 25 |
| GO:BP | GO:0014888 | striated muscle adaptation | "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] | 2 | 0.038648 | 25 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0043531 | ADP binding | "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl] | 2 | 0.013543 | 25 |
| GO:MF | GO:0017022 | myosin binding | "Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah] | 2 | 0.027946 | 25 |
| GO:MF | GO:0060001 | minus-end directed microfilament motor activity | "A motor activity that generates movement along a microfilament towards the minus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers." [GOC:dph, PMID:10519557] | 1 | 0.049992 | 25 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0091043 | Cerebellum; processes in white matter[High] | Cerebellum; processes in white matter[High] | 2 | 0.033893 | 25 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:756 | Prune-Gelsolin complex | Prune-Gelsolin complex | 1 | 0.049932 | 25 |
Community 26
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-72649 | Translation initiation complex formation | Translation initiation complex formation | 3 | 0.000099 | 26 |
| REAC | REAC:R-HSA-72702 | Ribosomal scanning and start codon recognition | Ribosomal scanning and start codon recognition | 3 | 0.000099 | 26 |
| REAC | REAC:R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 3 | 0.000104 | 26 |
| REAC | REAC:R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | L13a-mediated translational silencing of Ceruloplasmin expression | 3 | 0.000691 | 26 |
| REAC | REAC:R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | GTP hydrolysis and joining of the 60S ribosomal subunit | 3 | 0.000710 | 26 |
| REAC | REAC:R-HSA-72737 | Cap-dependent Translation Initiation | Cap-dependent Translation Initiation | 3 | 0.000851 | 26 |
| REAC | REAC:R-HSA-72613 | Eukaryotic Translation Initiation | Eukaryotic Translation Initiation | 3 | 0.000851 | 26 |
| REAC | REAC:R-HSA-72766 | Translation | Translation | 3 | 0.012294 | 26 |
| REAC | REAC:R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Formation of the ternary complex, and subsequently, the 43S complex | 2 | 0.022140 | 26 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002181 | cytoplasmic translation | "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] | 3 | 0.003723 | 26 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 4 | 0.005472 | 26 |
| GO:BP | GO:0002183 | cytoplasmic translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] | 2 | 0.037007 | 26 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003743 | translation initiation factor activity | "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] | 2 | 0.013543 | 26 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 5 | 0.016745 | 26 |
| GO:MF | GO:0003724 | RNA helicase activity | "Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098] | 2 | 0.027946 | 26 |
| GO:MF | GO:0008186 | ATP-dependent activity, acting on RNA | "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl] | 2 | 0.029440 | 26 |
| GO:MF | GO:0180051 | translation factor activity | "A molecular function required for translation of a mRNA into a protein functioning as part of initiation, elongation or termination of translation." [GOC:pg] | 2 | 0.040094 | 26 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 4 | 0.019078 | 26 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11309_1 | Factor: ATF-2; motif: NRTGACGTMANN; match class: 1 | Factor: ATF-2; motif: NRTGACGTMANN; match class: 1 | 5 | 0.021328 | 26 |
| TF | TF:M13113 | Factor: DMTF1; motif: NCATCCGGG | Factor: DMTF1; motif: NCATCCGGG | 4 | 0.029650 | 26 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP107 | Translation factors | Translation factors | 2 | 0.030423 | 26 |
Community 27
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005862 | muscle thin filament tropomyosin | "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194] | 4 | 1.103428e-13 | 27 |
| GO:CC | GO:0005865 | striated muscle thin filament | "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] | 4 | 9.764148e-10 | 27 |
| GO:CC | GO:0005884 | actin filament | "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] | 5 | 1.076628e-09 | 27 |
| GO:CC | GO:0036379 | myofilament | "Any of the smallest contractile units of a myofibril (striated muscle fiber)." [Wikipedia:Myofilament] | 4 | 1.934907e-09 | 27 |
| GO:CC | GO:0030017 | sarcomere | "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] | 5 | 1.952132e-08 | 27 |
| GO:CC | GO:0030016 | myofibril | "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] | 5 | 3.170542e-08 | 27 |
| GO:CC | GO:0043292 | contractile muscle fiber | "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] | 5 | 3.895024e-08 | 27 |
| GO:CC | GO:0097517 | contractile actin filament bundle | "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194] | 4 | 2.336249e-07 | 27 |
| GO:CC | GO:0001725 | stress fiber | "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] | 4 | 2.336249e-07 | 27 |
| GO:CC | GO:0042641 | actomyosin | "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] | 4 | 3.211359e-07 | 27 |
| GO:CC | GO:0032432 | actin filament bundle | "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] | 4 | 3.501264e-07 | 27 |
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 5 | 1.769447e-06 | 27 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 5 | 1.539406e-05 | 27 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 5 | 5.715723e-05 | 27 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 5 | 5.933440e-05 | 27 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 5 | 2.624989e-04 | 27 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 5 | 3.832913e-03 | 27 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0051015 | actin filament binding | "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] | 5 | 2.262520e-08 | 27 |
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 5 | 9.818465e-07 | 27 |
| GO:MF | GO:0008307 | structural constituent of muscle | "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] | 3 | 1.675548e-05 | 27 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 5 | 5.924022e-05 | 27 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 5 | 2.314511e-04 | 27 |
| GO:MF | GO:0042803 | protein homodimerization activity | "Binding to an identical protein to form a homodimer." [GOC:jl] | 4 | 1.657498e-03 | 27 |
| GO:MF | GO:0005198 | structural molecule activity | "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] | 4 | 8.577046e-03 | 27 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 4 | 9.207753e-03 | 27 |
| GO:MF | GO:0046982 | protein heterodimerization activity | "Binding to a nonidentical protein to form a heterodimer." [GOC:ai] | 3 | 1.126637e-02 | 27 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-390522 | Striated Muscle Contraction | Striated Muscle Contraction | 4 | 9.548287e-08 | 27 |
| REAC | REAC:R-HSA-445355 | Smooth Muscle Contraction | Smooth Muscle Contraction | 4 | 1.999411e-07 | 27 |
| REAC | REAC:R-HSA-397014 | Muscle contraction | Muscle contraction | 4 | 1.099806e-04 | 27 |
| REAC | REAC:R-HSA-9013424 | RHOV GTPase cycle | RHOV GTPase cycle | 2 | 2.168934e-02 | 27 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP383 | Striated muscle contraction pathway | Striated muscle contraction pathway | 4 | 1.448134e-07 | 27 |
| WP | WP:WP2005 | miR targeted genes in muscle cell | miR targeted genes in muscle cell | 4 | 1.171234e-03 | 27 |
| WP | WP:WP2004 | miR targeted genes in lymphocytes | miR targeted genes in lymphocytes | 4 | 2.442538e-03 | 27 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04260 | Cardiac muscle contraction | Cardiac muscle contraction | 4 | 0.000003 | 27 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | Hypertrophic cardiomyopathy | 4 | 0.000004 | 27 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | Dilated cardiomyopathy | 4 | 0.000005 | 27 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | Adrenergic signaling in cardiomyocytes | 4 | 0.000025 | 27 |
| KEGG | KEGG:04814 | Motor proteins | Motor proteins | 4 | 0.000063 | 27 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 5 | 0.000004 | 27 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 5 | 0.000039 | 27 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 5 | 0.000073 | 27 |
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 5 | 0.000090 | 27 |
| GO:BP | GO:0006936 | muscle contraction | "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] | 4 | 0.000292 | 27 |
| GO:BP | GO:0003012 | muscle system process | "An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] | 4 | 0.000725 | 27 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 5 | 0.001604 | 27 |
| GO:BP | GO:0030220 | platelet formation | "The process in which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194] | 2 | 0.010748 | 27 |
| GO:BP | GO:0036344 | platelet morphogenesis | "Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk] | 2 | 0.012573 | 27 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-1-3p | hsa-mir-1-3p | hsa-mir-1-3p | 5 | 0.000155 | 27 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0570762 | Testis; pachytene spermatocytes[≥Medium] | Testis; pachytene spermatocytes[≥Medium] | 5 | 0.013101 | 27 |
| HPA | HPA:0570792 | Testis; round or early spermatids[≥Medium] | Testis; round or early spermatids[≥Medium] | 5 | 0.013556 | 27 |
| HPA | HPA:0440343 | Skeletal muscle; myocytes[High] | Skeletal muscle; myocytes[High] | 4 | 0.016053 | 27 |
| HPA | HPA:0570793 | Testis; round or early spermatids[High] | Testis; round or early spermatids[High] | 4 | 0.030345 | 27 |
| HPA | HPA:0570791 | Testis; round or early spermatids[≥Low] | Testis; round or early spermatids[≥Low] | 5 | 0.036076 | 27 |
| HPA | HPA:0570761 | Testis; pachytene spermatocytes[≥Low] | Testis; pachytene spermatocytes[≥Low] | 5 | 0.039208 | 27 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002068 | Neuromuscular dysphagia | Neuromuscular dysphagia | 2 | 0.04165 | 27 |
| HP | HP:0004878 | Intercostal muscle weakness | Lack of strength of the intercostal muscles, i.e., of the muscle groups running along the ribs that create and move the chest wall. | 2 | 0.04165 | 27 |
| HP | HP:0007110 | Central hypoventilation | Central hypoventilation | 2 | 0.04996 | 27 |
Community 28
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070516 | CAK-ERCC2 complex | "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2." [PMID:8692841, PMID:8692842] | 3 | 4.886972e-09 | 28 |
| GO:CC | GO:0000439 | transcription factor TFIIH core complex | "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] | 3 | 2.014920e-07 | 28 |
| GO:CC | GO:0005675 | transcription factor TFIIH holo complex | "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] | 3 | 2.686378e-07 | 28 |
| GO:CC | GO:0032806 | carboxy-terminal domain protein kinase complex | "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683] | 3 | 1.391278e-06 | 28 |
| GO:CC | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] | 3 | 3.171800e-06 | 28 |
| GO:CC | GO:0070985 | transcription factor TFIIK complex | "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993] | 2 | 2.705733e-05 | 28 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 3 | 6.096375e-05 | 28 |
| GO:CC | GO:0016591 | RNA polymerase II, holoenzyme | "A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters." [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii] | 3 | 1.379484e-04 | 28 |
| GO:CC | GO:0055029 | nuclear DNA-directed RNA polymerase complex | "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu] | 3 | 2.839462e-04 | 28 |
| GO:CC | GO:0000428 | DNA-directed RNA polymerase complex | "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] | 3 | 3.319359e-04 | 28 |
| GO:CC | GO:0030880 | RNA polymerase complex | "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah] | 3 | 3.578305e-04 | 28 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 3 | 5.302287e-04 | 28 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 3 | 7.078595e-04 | 28 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 3 | 3.318942e-03 | 28 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 3 | 6.775921e-03 | 28 |
| GO:CC | GO:0005819 | spindle | "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] | 3 | 1.649739e-02 | 28 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 3 | 2.795403e-02 | 28 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2660 | CAK-ERCC2 complex | CAK-ERCC2 complex | 3 | 2.095106e-07 | 28 |
| CORUM | CORUM:1030 | CAK-ERCC2 complex | CAK-ERCC2 complex | 3 | 2.095106e-07 | 28 |
| CORUM | CORUM:107 | TFIIH transcription factor complex | TFIIH transcription factor complex | 3 | 4.389962e-06 | 28 |
| CORUM | CORUM:1036 | TFIIH transcription factor complex | TFIIH transcription factor complex | 3 | 4.389962e-06 | 28 |
| CORUM | CORUM:1009 | TFIIH transcription factor complex | TFIIH transcription factor complex | 3 | 6.268588e-06 | 28 |
| CORUM | CORUM:1029 | TFIIH transcription factor complex | TFIIH transcription factor complex | 3 | 6.268588e-06 | 28 |
| CORUM | CORUM:1008 | CAK complex (Cdk-activating kinase complex) | CAK complex (Cdk-activating kinase complex) | 2 | 1.770626e-04 | 28 |
| CORUM | CORUM:1010 | CAK complex (Cdk-activating kinase complex) | CAK complex (Cdk-activating kinase complex) | 2 | 1.770626e-04 | 28 |
| CORUM | CORUM:2657 | ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex | ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex | 2 | 8.837426e-04 | 28 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | RNA Pol II CTD phosphorylation and interaction with CE | 3 | 0.000023 | 28 |
| REAC | REAC:R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 3 | 0.000023 | 28 |
| REAC | REAC:R-HSA-72086 | mRNA Capping | mRNA Capping | 3 | 0.000029 | 28 |
| REAC | REAC:R-HSA-73863 | RNA Polymerase I Transcription Termination | RNA Polymerase I Transcription Termination | 3 | 0.000040 | 28 |
| REAC | REAC:R-HSA-113418 | Formation of the Early Elongation Complex | Formation of the Early Elongation Complex | 3 | 0.000044 | 28 |
| REAC | REAC:R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | Formation of the HIV-1 Early Elongation Complex | 3 | 0.000044 | 28 |
| REAC | REAC:R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3 | 0.000102 | 28 |
| REAC | REAC:R-HSA-167169 | HIV Transcription Elongation | HIV Transcription Elongation | 3 | 0.000102 | 28 |
| REAC | REAC:R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | Tat-mediated elongation of the HIV-1 transcript | 3 | 0.000102 | 28 |
| REAC | REAC:R-HSA-5696395 | Formation of Incision Complex in GG-NER | Formation of Incision Complex in GG-NER | 3 | 0.000110 | 28 |
| REAC | REAC:R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | Formation of HIV elongation complex in the absence of HIV Tat | 3 | 0.000118 | 28 |
| REAC | REAC:R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | RNA Polymerase II HIV Promoter Escape | 3 | 0.000135 | 28 |
| REAC | REAC:R-HSA-167161 | HIV Transcription Initiation | HIV Transcription Initiation | 3 | 0.000135 | 28 |
| REAC | REAC:R-HSA-73776 | RNA Polymerase II Promoter Escape | RNA Polymerase II Promoter Escape | 3 | 0.000135 | 28 |
| REAC | REAC:R-HSA-75953 | RNA Polymerase II Transcription Initiation | RNA Polymerase II Transcription Initiation | 3 | 0.000135 | 28 |
| REAC | REAC:R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | RNA Polymerase II Transcription Initiation And Promoter Clearance | 3 | 0.000135 | 28 |
| REAC | REAC:R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3 | 0.000135 | 28 |
| REAC | REAC:R-HSA-73762 | RNA Polymerase I Transcription Initiation | RNA Polymerase I Transcription Initiation | 3 | 0.000144 | 28 |
| REAC | REAC:R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | Formation of TC-NER Pre-Incision Complex | 3 | 0.000174 | 28 |
| REAC | REAC:R-HSA-112382 | Formation of RNA Pol II elongation complex | Formation of RNA Pol II elongation complex | 3 | 0.000260 | 28 |
| REAC | REAC:R-HSA-75955 | RNA Polymerase II Transcription Elongation | RNA Polymerase II Transcription Elongation | 3 | 0.000260 | 28 |
| REAC | REAC:R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | TP53 Regulates Transcription of DNA Repair Genes | 3 | 0.000319 | 28 |
| REAC | REAC:R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | Gap-filling DNA repair synthesis and ligation in TC-NER | 3 | 0.000319 | 28 |
| REAC | REAC:R-HSA-6782135 | Dual incision in TC-NER | Dual incision in TC-NER | 3 | 0.000335 | 28 |
| REAC | REAC:R-HSA-167172 | Transcription of the HIV genome | Transcription of the HIV genome | 3 | 0.000464 | 28 |
| REAC | REAC:R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3 | 0.000598 | 28 |
| REAC | REAC:R-HSA-674695 | RNA Polymerase II Pre-transcription Events | RNA Polymerase II Pre-transcription Events | 3 | 0.000727 | 28 |
| REAC | REAC:R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | Global Genome Nucleotide Excision Repair (GG-NER) | 3 | 0.000842 | 28 |
| REAC | REAC:R-HSA-73772 | RNA Polymerase I Promoter Escape | RNA Polymerase I Promoter Escape | 3 | 0.001037 | 28 |
| REAC | REAC:R-HSA-427413 | NoRC negatively regulates rRNA expression | NoRC negatively regulates rRNA expression | 3 | 0.001652 | 28 |
| REAC | REAC:R-HSA-5696398 | Nucleotide Excision Repair | Nucleotide Excision Repair | 3 | 0.001749 | 28 |
| REAC | REAC:R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | Negative epigenetic regulation of rRNA expression | 3 | 0.001799 | 28 |
| REAC | REAC:R-HSA-73854 | RNA Polymerase I Promoter Clearance | RNA Polymerase I Promoter Clearance | 3 | 0.001849 | 28 |
| REAC | REAC:R-HSA-73864 | RNA Polymerase I Transcription | RNA Polymerase I Transcription | 3 | 0.001901 | 28 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 3 | 0.003215 | 28 |
| REAC | REAC:R-HSA-162599 | Late Phase of HIV Life Cycle | Late Phase of HIV Life Cycle | 3 | 0.003290 | 28 |
| REAC | REAC:R-HSA-162587 | HIV Life Cycle | HIV Life Cycle | 3 | 0.004362 | 28 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 3 | 0.004638 | 28 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 4 | 0.005842 | 28 |
| REAC | REAC:R-HSA-212165 | Epigenetic regulation of gene expression | Epigenetic regulation of gene expression | 3 | 0.009050 | 28 |
| REAC | REAC:R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | Cyclin A/B1/B2 associated events during G2/M transition | 2 | 0.010605 | 28 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 4 | 0.013563 | 28 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 3 | 0.016454 | 28 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 2 | 0.035140 | 28 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 2 | 0.035140 | 28 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03022 | Basal transcription factors | Basal transcription factors | 3 | 0.000026 | 28 |
| KEGG | KEGG:03420 | Nucleotide excision repair | Nucleotide excision repair | 3 | 0.000076 | 28 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP405 | Eukaryotic transcription initiation | Eukaryotic transcription initiation | 3 | 0.000032 | 28 |
| WP | WP:WP4753 | Nucleotide excision repair | Nucleotide excision repair | 3 | 0.000037 | 28 |
| WP | WP:WP5114 | Nucleotide excision repair in xeroderma pigmentosum | Nucleotide excision repair in xeroderma pigmentosum | 3 | 0.000195 | 28 |
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 3 | 0.000820 | 28 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 2 | 0.026427 | 28 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 5 | 0.000044 | 28 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 5 | 0.000108 | 28 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 0.000225 | 28 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 0.000655 | 28 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 5 | 0.000659 | 28 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 4 | 0.000661 | 28 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 0.001154 | 28 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 4 | 0.001576 | 28 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 5 | 0.002443 | 28 |
| GO:BP | GO:0006367 | transcription initiation at RNA polymerase II promoter | "A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH] | 3 | 0.004145 | 28 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 4 | 0.005265 | 28 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 3 | 0.006836 | 28 |
| GO:BP | GO:0006352 | DNA-templated transcription initiation | "The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161] | 3 | 0.007681 | 28 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 3 | 0.010089 | 28 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 4 | 0.027036 | 28 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 2 | 0.011091 | 28 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 2 | 0.026490 | 28 |
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 2 | 0.026490 | 28 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 3 | 0.040229 | 28 |
Community 29
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00620 | Pyruvate metabolism | Pyruvate metabolism | 3 | 0.000078 | 29 |
| KEGG | KEGG:00010 | Glycolysis / Gluconeogenesis | Glycolysis / Gluconeogenesis | 3 | 0.000228 | 29 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | Central carbon metabolism in cancer | 3 | 0.000261 | 29 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | Glucagon signaling pathway | 3 | 0.000939 | 29 |
| KEGG | KEGG:00640 | Propanoate metabolism | Propanoate metabolism | 2 | 0.006709 | 29 |
| KEGG | KEGG:00270 | Cysteine and methionine metabolism | Cysteine and methionine metabolism | 2 | 0.016499 | 29 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP534 | Glycolysis and gluconeogenesis | Glycolysis and gluconeogenesis | 3 | 0.000121 | 29 |
| WP | WP:WP5211 | Glucose metabolism in triple negative breast cancer cells | Glucose metabolism in triple negative breast cancer cells | 2 | 0.000702 | 29 |
| WP | WP:WP4018 | Clear cell renal cell carcinoma pathways | Clear cell renal cell carcinoma pathways | 3 | 0.000838 | 29 |
| WP | WP:WP5355 | Metabolic epileptic disorders | Metabolic epileptic disorders | 3 | 0.001030 | 29 |
| WP | WP:WP5049 | Glycolysis in senescence | Glycolysis in senescence | 2 | 0.001378 | 29 |
| WP | WP:WP5314 | Lactate shuttle in glial cells | Lactate shuttle in glial cells | 2 | 0.001954 | 29 |
| WP | WP:WP4628 | Aerobic glycolysis augmented | Aerobic glycolysis augmented | 2 | 0.001954 | 29 |
| WP | WP:WP4236 | Krebs cycle disorders | Krebs cycle disorders | 2 | 0.001954 | 29 |
| WP | WP:WP3614 | Photodynamic therapy induced HIF 1 survival signaling | Photodynamic therapy induced HIF 1 survival signaling | 2 | 0.016589 | 29 |
| WP | WP:WP4290 | Metabolic reprogramming in colon cancer | Metabolic reprogramming in colon cancer | 2 | 0.021422 | 29 |
| WP | WP:WP5220 | Metabolic reprogramming in pancreatic cancer | Metabolic reprogramming in pancreatic cancer | 2 | 0.021422 | 29 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004459 | L-lactate dehydrogenase activity | "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27, RHEA:23444] | 2 | 0.000148 | 29 |
| GO:MF | GO:0004457 | lactate dehydrogenase activity | "Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate." [GOC:ai, GOC:bf] | 2 | 0.000207 | 29 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 3 | 0.041746 | 29 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006090 | pyruvate metabolic process | "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] | 3 | 0.001575 | 29 |
| GO:BP | GO:0019362 | pyridine nucleotide metabolic process | "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] | 3 | 0.003523 | 29 |
| GO:BP | GO:0046496 | nicotinamide nucleotide metabolic process | "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] | 3 | 0.003523 | 29 |
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 3 | 0.004001 | 29 |
| GO:BP | GO:0006089 | lactate metabolic process | "The chemical reactions and pathways involving lactate, the anion of lactic acid." [ISBN:0198547684] | 2 | 0.006130 | 29 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 5 | 0.001732 | 29 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 5 | 0.001859 | 29 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 5 | 0.001864 | 29 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 5 | 0.001864 | 29 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 5 | 0.016573 | 29 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 5 | 0.044193 | 29 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-324-5p | hsa-mir-324-5p | hsa-mir-324-5p | 4 | 0.010068 | 29 |
| MIRNA | MIRNA:hsa-mir-23a-3p | hsa-mir-23a-3p | hsa-mir-23a-3p | 3 | 0.011943 | 29 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 2 | 0.022890 | 29 |
| REAC | REAC:R-HSA-70268 | Pyruvate metabolism | Pyruvate metabolism | 2 | 0.032194 | 29 |
| REAC | REAC:R-HSA-9020591 | Interleukin-12 signaling | Interleukin-12 signaling | 2 | 0.036662 | 29 |
Community 30
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-69183 | Processive synthesis on the lagging strand | Processive synthesis on the lagging strand | 5 | 4.435554e-13 | 30 |
| REAC | REAC:R-HSA-69186 | Lagging Strand Synthesis | Lagging Strand Synthesis | 5 | 2.290004e-12 | 30 |
| REAC | REAC:R-HSA-69190 | DNA strand elongation | DNA strand elongation | 5 | 2.974406e-11 | 30 |
| REAC | REAC:R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | Telomere C-strand (Lagging Strand) Synthesis | 5 | 4.109955e-11 | 30 |
| REAC | REAC:R-HSA-180786 | Extension of Telomeres | Extension of Telomeres | 5 | 3.469658e-10 | 30 |
| REAC | REAC:R-HSA-69166 | Removal of the Flap Intermediate | Removal of the Flap Intermediate | 4 | 1.625187e-09 | 30 |
| REAC | REAC:R-HSA-69109 | Leading Strand Synthesis | Leading Strand Synthesis | 4 | 1.625187e-09 | 30 |
| REAC | REAC:R-HSA-69091 | Polymerase switching | Polymerase switching | 4 | 1.625187e-09 | 30 |
| REAC | REAC:R-HSA-157579 | Telomere Maintenance | Telomere Maintenance | 5 | 1.893045e-08 | 30 |
| REAC | REAC:R-HSA-174411 | Polymerase switching on the C-strand of the telomere | Polymerase switching on the C-strand of the telomere | 4 | 2.425107e-08 | 30 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 5 | 2.936248e-08 | 30 |
| REAC | REAC:R-HSA-73886 | Chromosome Maintenance | Chromosome Maintenance | 5 | 5.725170e-08 | 30 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 5 | 1.290406e-07 | 30 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 5 | 2.666898e-07 | 30 |
| REAC | REAC:R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3 | 3.248158e-06 | 30 |
| REAC | REAC:R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3 | 3.248158e-06 | 30 |
| REAC | REAC:R-HSA-5358508 | Mismatch Repair | Mismatch Repair | 3 | 4.059643e-06 | 30 |
| REAC | REAC:R-HSA-174414 | Processive synthesis on the C-strand of the telomere | Processive synthesis on the C-strand of the telomere | 3 | 8.640983e-06 | 30 |
| REAC | REAC:R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | PCNA-Dependent Long Patch Base Excision Repair | 3 | 1.185694e-05 | 30 |
| REAC | REAC:R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3 | 2.049328e-05 | 30 |
| REAC | REAC:R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | Gap-filling DNA repair synthesis and ligation in GG-NER | 3 | 2.049328e-05 | 30 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 5 | 6.027548e-05 | 30 |
| REAC | REAC:R-HSA-73933 | Resolution of Abasic Sites (AP sites) | Resolution of Abasic Sites (AP sites) | 3 | 6.352275e-05 | 30 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 5 | 1.750451e-04 | 30 |
| REAC | REAC:R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | Gap-filling DNA repair synthesis and ligation in TC-NER | 3 | 3.191010e-04 | 30 |
| REAC | REAC:R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3 | 5.975557e-04 | 30 |
| REAC | REAC:R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | Global Genome Nucleotide Excision Repair (GG-NER) | 3 | 8.421670e-04 | 30 |
| REAC | REAC:R-HSA-68952 | DNA replication initiation | DNA replication initiation | 2 | 9.166890e-04 | 30 |
| REAC | REAC:R-HSA-73884 | Base Excision Repair | Base Excision Repair | 3 | 9.693693e-04 | 30 |
| REAC | REAC:R-HSA-5696398 | Nucleotide Excision Repair | Nucleotide Excision Repair | 3 | 1.748783e-03 | 30 |
| REAC | REAC:R-HSA-174430 | Telomere C-strand synthesis initiation | Telomere C-strand synthesis initiation | 2 | 2.551313e-03 | 30 |
| REAC | REAC:R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 2 | 2.975990e-03 | 30 |
| REAC | REAC:R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | Removal of the Flap Intermediate from the C-strand | 2 | 4.445207e-03 | 30 |
| REAC | REAC:R-HSA-113510 | E2F mediated regulation of DNA replication | E2F mediated regulation of DNA replication | 2 | 8.260369e-03 | 30 |
| REAC | REAC:R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | Recognition of DNA damage by PCNA-containing replication complex | 2 | 1.418453e-02 | 30 |
| REAC | REAC:R-HSA-5656169 | Termination of translesion DNA synthesis | Termination of translesion DNA synthesis | 2 | 1.616774e-02 | 30 |
| REAC | REAC:R-HSA-68962 | Activation of the pre-replicative complex | Activation of the pre-replicative complex | 2 | 1.720768e-02 | 30 |
| REAC | REAC:R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | 2 | 2.412305e-02 | 30 |
| REAC | REAC:R-HSA-5696400 | Dual Incision in GG-NER | Dual Incision in GG-NER | 2 | 2.668515e-02 | 30 |
| REAC | REAC:R-HSA-73893 | DNA Damage Bypass | DNA Damage Bypass | 2 | 3.666158e-02 | 30 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03030 | DNA replication | DNA replication | 5 | 5.051169e-11 | 30 |
| KEGG | KEGG:03430 | Mismatch repair | Mismatch repair | 3 | 8.502638e-06 | 30 |
| KEGG | KEGG:03410 | Base excision repair | Base excision repair | 3 | 6.334861e-05 | 30 |
| KEGG | KEGG:03420 | Nucleotide excision repair | Nucleotide excision repair | 3 | 1.716282e-04 | 30 |
| KEGG | KEGG:03440 | Homologous recombination | Homologous recombination | 2 | 1.106789e-02 | 30 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0042575 | DNA polymerase complex | "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, PMID:12045093] | 4 | 5.343018e-10 | 30 |
| GO:CC | GO:0043601 | nuclear replisome | "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] | 4 | 8.066327e-10 | 30 |
| GO:CC | GO:0030894 | replisome | "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] | 4 | 1.171655e-09 | 30 |
| GO:CC | GO:0043596 | nuclear replication fork | "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] | 4 | 1.115948e-08 | 30 |
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 4 | 1.337722e-07 | 30 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 4 | 1.355255e-05 | 30 |
| GO:CC | GO:0032993 | protein-DNA complex | "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] | 4 | 1.524839e-05 | 30 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 4 | 4.976842e-05 | 30 |
| GO:CC | GO:0043625 | delta DNA polymerase complex | "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614] | 2 | 5.410978e-05 | 30 |
| GO:CC | GO:0005658 | alpha DNA polymerase:primase complex | "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a small stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402, PMID:26975377] | 2 | 9.017481e-05 | 30 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 4 | 3.029556e-03 | 30 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 4 | 3.534296e-03 | 30 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 4 | 4.295262e-02 | 30 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1107 | DNA synthesome core complex | DNA synthesome core complex | 4 | 9.717787e-10 | 30 |
| CORUM | CORUM:1098 | DNA synthesome complex (13 subunits) | DNA synthesome complex (13 subunits) | 4 | 1.619631e-09 | 30 |
| CORUM | CORUM:1108 | DNA synthesome complex (15 subunits) | DNA synthesome complex (15 subunits) | 4 | 5.514458e-09 | 30 |
| CORUM | CORUM:1099 | DNA synthesome complex (17 subunits) | DNA synthesome complex (17 subunits) | 4 | 7.720242e-09 | 30 |
| CORUM | CORUM:1111 | DNA synthesome complex (17 subunits) | DNA synthesome complex (17 subunits) | 4 | 7.720242e-09 | 30 |
| CORUM | CORUM:1100 | DNA polymerase alpha-primase complex | DNA polymerase alpha-primase complex | 2 | 2.642027e-04 | 30 |
| CORUM | CORUM:297 | PCNA-DNA polymerase delta complex | PCNA-DNA polymerase delta complex | 2 | 2.642027e-04 | 30 |
| CORUM | CORUM:1003 | RC complex (Replication competent complex) | RC complex (Replication competent complex) | 2 | 1.231001e-03 | 30 |
| CORUM | CORUM:1004 | RC complex during S-phase of cell cycle | RC complex during S-phase of cell cycle | 2 | 1.582091e-03 | 30 |
| CORUM | CORUM:1005 | RC complex during G2/M-phase of cell cycle | RC complex during G2/M-phase of cell cycle | 2 | 1.976833e-03 | 30 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006261 | DNA-templated DNA replication | "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] | 5 | 1.902178e-08 | 30 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 5 | 3.384986e-07 | 30 |
| GO:BP | GO:0006271 | DNA strand elongation involved in DNA replication | "The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication." [GOC:mah, ISBN:071673706X, ISBN:0815316194] | 3 | 2.329229e-06 | 30 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 4 | 1.705185e-05 | 30 |
| GO:BP | GO:0022616 | DNA strand elongation | "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:isa_complete, GOC:mah] | 3 | 3.971363e-05 | 30 |
| GO:BP | GO:0000731 | DNA synthesis involved in DNA repair | "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855] | 3 | 6.765821e-05 | 30 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 5 | 1.961351e-04 | 30 |
| GO:BP | GO:0006273 | lagging strand elongation | "The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork." [GOC:mah, ISBN:071673706X, ISBN:0815316194] | 2 | 2.153949e-04 | 30 |
| GO:BP | GO:0006269 | DNA replication, synthesis of primer | "The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer." [PMID:11395402, PMID:38203225, PMID:38492718] | 2 | 1.004794e-03 | 30 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 4 | 2.921058e-03 | 30 |
| GO:BP | GO:0006287 | base-excision repair, gap-filling | "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131] | 2 | 3.263716e-03 | 30 |
| GO:BP | GO:1902969 | mitotic DNA replication | "Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] | 2 | 4.876249e-03 | 30 |
| GO:BP | GO:0019985 | translesion synthesis | "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901] | 2 | 1.164282e-02 | 30 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 4 | 1.324229e-02 | 30 |
| GO:BP | GO:0006301 | postreplication repair | "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh] | 2 | 2.254769e-02 | 30 |
| GO:BP | GO:0006270 | DNA replication initiation | "The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641] | 2 | 2.383386e-02 | 30 |
| GO:BP | GO:0033260 | nuclear DNA replication | "The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] | 2 | 2.933382e-02 | 30 |
| GO:BP | GO:0044786 | cell cycle DNA replication | "The DNA-dependent DNA replication that takes place as part of the cell cycle." [GOC:mtg_cell_cycle] | 2 | 3.540173e-02 | 30 |
| GO:BP | GO:0006284 | base-excision repair | "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] | 2 | 3.700738e-02 | 30 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP466 | DNA replication | DNA replication | 4 | 2.195084e-07 | 30 |
| WP | WP:WP4022 | Pyrimidine metabolism | Pyrimidine metabolism | 4 | 3.769402e-06 | 30 |
| WP | WP:WP531 | DNA mismatch repair | DNA mismatch repair | 3 | 1.519403e-05 | 30 |
| WP | WP:WP4752 | Base excision repair | Base excision repair | 3 | 3.851122e-05 | 30 |
| WP | WP:WP4753 | Nucleotide excision repair | Nucleotide excision repair | 3 | 1.055145e-04 | 30 |
| WP | WP:WP5114 | Nucleotide excision repair in xeroderma pigmentosum | Nucleotide excision repair in xeroderma pigmentosum | 3 | 5.512883e-04 | 30 |
| WP | WP:WP186 | Homologous recombination | Homologous recombination | 2 | 1.953592e-03 | 30 |
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 3 | 2.310630e-03 | 30 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 5 | 0.001077 | 30 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 5 | 0.006522 | 30 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 4 | 0.021365 | 30 |
| HPA | HPA:0320892 | Nasopharynx; goblet cells[≥Medium] | Nasopharynx; goblet cells[≥Medium] | 3 | 0.023545 | 30 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 4 | 0.030928 | 30 |
| HPA | HPA:0320891 | Nasopharynx; goblet cells[≥Low] | Nasopharynx; goblet cells[≥Low] | 3 | 0.031019 | 30 |
| HPA | HPA:0470683 | Skin 2; epidermal cells[High] | Skin 2; epidermal cells[High] | 4 | 0.032602 | 30 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003887 | DNA-directed DNA polymerase activity | "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time." [EC:2.7.7.7, GOC:vw] | 2 | 0.002720 | 30 |
| GO:MF | GO:0140097 | catalytic activity, acting on DNA | "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] | 3 | 0.004158 | 30 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 5 | 0.006294 | 30 |
| GO:MF | GO:0034061 | DNA polymerase activity | "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)." [RHEA:22508] | 2 | 0.007676 | 30 |
Community 31
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-162909 | Host Interactions of HIV factors | Host Interactions of HIV factors | 2 | 0.036309 | 31 |
Community 32
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 5 | 3.987462e-08 | 32 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 5 | 9.987266e-08 | 32 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 5 | 5.249292e-07 | 32 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | Progesterone-mediated oocyte maturation | 4 | 4.783737e-06 | 32 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | Ubiquitin mediated proteolysis | 3 | 2.104552e-03 | 32 |
| KEGG | KEGG:04115 | p53 signaling pathway | p53 signaling pathway | 2 | 3.617303e-02 | 32 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP179 | Cell cycle | Cell cycle | 5 | 4.287267e-08 | 32 |
| WP | WP:WP3391 | Senescence associated secretory phenotype SASP | Senescence associated secretory phenotype SASP | 3 | 1.925641e-03 | 32 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4 | 9.548287e-08 | 32 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 4 | 1.196340e-07 | 32 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 4 | 1.759547e-06 | 32 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 5 | 2.396594e-06 | 32 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 4 | 4.510735e-06 | 32 |
| REAC | REAC:R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 3 | 1.016448e-05 | 32 |
| REAC | REAC:R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 3 | 1.016448e-05 | 32 |
| REAC | REAC:R-HSA-176412 | Phosphorylation of the APC/C | Phosphorylation of the APC/C | 3 | 1.016448e-05 | 32 |
| REAC | REAC:R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | Inactivation of APC/C via direct inhibition of the APC/C complex | 3 | 1.185694e-05 | 32 |
| REAC | REAC:R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | 3 | 1.185694e-05 | 32 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 4 | 1.368543e-05 | 32 |
| REAC | REAC:R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | APC/C:Cdc20 mediated degradation of Cyclin B | 3 | 1.803655e-05 | 32 |
| REAC | REAC:R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | APC-Cdc20 mediated degradation of Nek2A | 3 | 2.316315e-05 | 32 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 4 | 4.440303e-05 | 32 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 5 | 6.027548e-05 | 32 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 4 | 7.908592e-05 | 32 |
| REAC | REAC:R-HSA-8853884 | Transcriptional Regulation by VENTX | Transcriptional Regulation by VENTX | 3 | 8.127402e-05 | 32 |
| REAC | REAC:R-HSA-2559583 | Cellular Senescence | Cellular Senescence | 4 | 9.166944e-05 | 32 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 5 | 1.750451e-04 | 32 |
| REAC | REAC:R-HSA-68882 | Mitotic Anaphase | Mitotic Anaphase | 4 | 1.752638e-04 | 32 |
| REAC | REAC:R-HSA-2555396 | Mitotic Metaphase and Anaphase | Mitotic Metaphase and Anaphase | 4 | 1.783665e-04 | 32 |
| REAC | REAC:R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | Autodegradation of Cdh1 by Cdh1:APC/C | 3 | 3.692572e-04 | 32 |
| REAC | REAC:R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | APC/C:Cdc20 mediated degradation of Securin | 3 | 4.439219e-04 | 32 |
| REAC | REAC:R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3 | 5.505481e-04 | 32 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 3 | 5.737321e-04 | 32 |
| REAC | REAC:R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 3 | 5.737321e-04 | 32 |
| REAC | REAC:R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | APC/C:Cdc20 mediated degradation of mitotic proteins | 3 | 6.220276e-04 | 32 |
| REAC | REAC:R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3 | 6.471563e-04 | 32 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 3 | 7.544104e-04 | 32 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 3 | 9.693693e-04 | 32 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 3 | 9.693693e-04 | 32 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 4 | 1.776690e-03 | 32 |
| REAC | REAC:R-HSA-69618 | Mitotic Spindle Checkpoint | Mitotic Spindle Checkpoint | 3 | 1.849148e-03 | 32 |
| REAC | REAC:R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | Senescence-Associated Secretory Phenotype (SASP) | 3 | 1.953262e-03 | 32 |
| REAC | REAC:R-HSA-68867 | Assembly of the pre-replicative complex | Assembly of the pre-replicative complex | 3 | 4.096412e-03 | 32 |
| REAC | REAC:R-HSA-69002 | DNA Replication Pre-Initiation | DNA Replication Pre-Initiation | 3 | 5.750502e-03 | 32 |
| REAC | REAC:R-HSA-2467813 | Separation of Sister Chromatids | Separation of Sister Chromatids | 3 | 9.495725e-03 | 32 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 4 | 2.542044e-02 | 32 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 4 | 2.723066e-02 | 32 |
| REAC | REAC:R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | Antigen processing: Ubiquitination & Proteasome degradation | 3 | 4.132449e-02 | 32 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051321 | meiotic cell cycle | "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] | 5 | 4.316561e-07 | 32 |
| GO:BP | GO:0141198 | protein branched polyubiquitination | "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at various positions of the ubiquitin monomers, forming branched linkages, such as K11/K48- or K11/K63-linked chains." [PMID:29033132, PMID:29378950, PMID:31998699, PMID:37325469] | 3 | 3.480548e-06 | 32 |
| GO:BP | GO:0031145 | anaphase-promoting complex-dependent catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442] | 3 | 1.176572e-05 | 32 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 5 | 2.347291e-05 | 32 |
| GO:BP | GO:0070979 | protein K11-linked ubiquitination | "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135] | 3 | 4.670411e-05 | 32 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 5 | 1.078947e-04 | 32 |
| GO:BP | GO:0098813 | nuclear chromosome segregation | "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos] | 4 | 2.143412e-04 | 32 |
| GO:BP | GO:0051445 | regulation of meiotic cell cycle | "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 3 | 2.555834e-04 | 32 |
| GO:BP | GO:0019953 | sexual reproduction | "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] | 5 | 3.405188e-04 | 32 |
| GO:BP | GO:0007059 | chromosome segregation | "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] | 4 | 6.549997e-04 | 32 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 4 | 6.611534e-04 | 32 |
| GO:BP | GO:0070936 | protein K48-linked ubiquitination | "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404] | 3 | 7.981323e-04 | 32 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 1.153738e-03 | 32 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 4 | 1.576229e-03 | 32 |
| GO:BP | GO:0022414 | reproductive process | "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] | 5 | 2.064332e-03 | 32 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 5 | 2.442869e-03 | 32 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 4 | 6.031093e-03 | 32 |
| GO:BP | GO:2000241 | regulation of reproductive process | "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] | 3 | 6.938197e-03 | 32 |
| GO:BP | GO:0000209 | protein polyubiquitination | "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [PMID:26906419] | 3 | 1.818047e-02 | 32 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 4 | 2.703565e-02 | 32 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005680 | anaphase-promoting complex | "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] | 3 | 0.000002 | 32 |
| GO:CC | GO:0000152 | nuclear ubiquitin ligase complex | "A ubiquitin ligase complex found in the nucleus." [GOC:mah] | 3 | 0.000022 | 32 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 5 | 0.000026 | 32 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 5 | 0.000736 | 32 |
| GO:CC | GO:0031461 | cullin-RING ubiquitin ligase complex | "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] | 3 | 0.001357 | 32 |
| GO:CC | GO:0000151 | ubiquitin ligase complex | "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] | 3 | 0.006652 | 32 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 2 | 0.020425 | 32 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:96 | Anaphase-promoting complex | Anaphase-promoting complex | 2 | 0.000827 | 32 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 2 | 0.011091 | 32 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 2 | 0.026490 | 32 |
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 2 | 0.026490 | 32 |
Community 33
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0046970 | histone H4K16 deacetylase activity, NAD-dependent | "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + NAD+ + H2O = histone H4 L-lysine (position 16) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H4K16 to NAD, producing nicotinamide." [GOC:vw, PMID:28450737] | 2 | 0.000010 | 33 |
| GO:MF | GO:0141051 | histone H4K deacetylase activity | "Removal of an acetyl group from a lysine residue in a histone H4." [PMID:12590135] | 2 | 0.000030 | 33 |
| GO:MF | GO:0017136 | histone deacetylase activity, NAD-dependent | "Catalysis of the reaction: N(6)-acetyl-L-lysyl-[histone] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a histone to NAD, producing nicotinamide." [PMID:24691964, PMID:28450737] | 2 | 0.000099 | 33 |
| GO:MF | GO:0141218 | NAD-dependent protein lysine deacylase activity | "Catalysis of the reaction: N6-acyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-acyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]." [PMID:35044827, RHEA:54172] | 2 | 0.000207 | 33 |
| GO:MF | GO:0034979 | NAD-dependent protein lysine deacetylase activity | "Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a protein to NAD, producing nicotinamide." [GOC:BHF, GOC:mah, RHEA:43636] | 2 | 0.000207 | 33 |
| GO:MF | GO:0070403 | NAD+ binding | "Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] | 2 | 0.001184 | 33 |
| GO:MF | GO:0004407 | histone deacetylase activity | "Removal of an acetyl group from a lysine residue in a histone." [PMID:24691964, PMID:9893272] | 2 | 0.003724 | 33 |
| GO:MF | GO:0033558 | protein lysine deacetylase activity | "Catalysis of the reaction: Removal of an acetyl group from a lysine residue in a protein." [PMID:27296530, RHEA:58108] | 2 | 0.003724 | 33 |
| GO:MF | GO:0019213 | deacetylase activity | "Catalysis of the hydrolysis of an acetyl group from a substrate molecule." [GOC:jl] | 2 | 0.009305 | 33 |
| GO:MF | GO:0051287 | NAD binding | "Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] | 2 | 0.013543 | 33 |
| GO:MF | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [EC:3.5.1.-] | 2 | 0.019791 | 33 |
| GO:MF | GO:0002039 | p53 binding | "Binding to one of the p53 family of proteins." [GOC:hjd] | 2 | 0.023020 | 33 |
| GO:MF | GO:0160215 | deacylase activity | "Catalysis of the reaction: R-CO-X + H2O = R-COOH + HX, hydrolysis of an acyl group or groups from a substrate molecule." [PMID:2760018, PMID:29637793, PMID:38355760] | 2 | 0.026490 | 33 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 3 | 0.027175 | 33 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 3 | 0.049893 | 33 |
| GO:MF | GO:0160012 | NAD-dependent histone decrotonylase activity | "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone] + nicotinamide." [PMID:28497810] | 1 | 0.049992 | 33 |
| GO:MF | GO:0160011 | NAD-dependent protein decrotonylase activity | "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [PMID:28497810] | 1 | 0.049992 | 33 |
| GO:MF | GO:0141208 | NAD-dependent protein lysine delactylase activity | "Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, transfering a lactoyl group attached to a lysine residue in a protein to NAD." [PMID:38512451, RHEA:80287] | 1 | 0.049992 | 33 |
| GO:MF | GO:0140937 | histone H4K12 deacetylase activity, hydrolytic mechanism | "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein." [GOC:vw, PMID:15293224] | 1 | 0.049992 | 33 |
| GO:MF | GO:0032041 | histone H3K14 deacetylase activity, NAD-dependent | "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + NAD+ + H2O = histone H3 L-lysine (position 14) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K14 to NAD, producing nicotinamide." [PMID:28450737] | 1 | 0.049992 | 33 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522] | 3 | 0.000063 | 33 |
| GO:BP | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:ai, GOC:mtg_apoptosis] | 3 | 0.000175 | 33 |
| GO:BP | GO:0010506 | regulation of autophagy | "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] | 4 | 0.000357 | 33 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 5 | 0.000786 | 33 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 5 | 0.001168 | 33 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 5 | 0.001172 | 33 |
| GO:BP | GO:0000183 | rDNA heterochromatin formation | "The formation of heterochromatin at ribosomal DNA, characterized by the modified histone H3K9me3." [PMID:10219245] | 2 | 0.001292 | 33 |
| GO:BP | GO:1990700 | nucleolar chromatin organization | "Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin." [PMID:18362178] | 2 | 0.001615 | 33 |
| GO:BP | GO:0071456 | cellular response to hypoxia | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] | 3 | 0.002370 | 33 |
| GO:BP | GO:2000377 | regulation of reactive oxygen species metabolic process | "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] | 3 | 0.002472 | 33 |
| GO:BP | GO:0061919 | process utilizing autophagic mechanism | "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] | 4 | 0.002496 | 33 |
| GO:BP | GO:0006914 | autophagy | "The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464] | 4 | 0.002496 | 33 |
| GO:BP | GO:0062013 | positive regulation of small molecule metabolic process | "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] | 3 | 0.002524 | 33 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 5 | 0.002570 | 33 |
| GO:BP | GO:0036294 | cellular response to decreased oxygen levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] | 3 | 0.002739 | 33 |
| GO:BP | GO:0140718 | facultative heterochromatin formation | "The compaction of chromatin into a conformation that is refractory to transcription but that can be converted to euchromatin and allow transcription in specific contexts. These can be temporal (e.g., developmental states or specific cell-cycle stages), spatial (e.g., nuclear localization changes from the center to the periphery or vice versa due to exogenous factors/signals), or parental/heritable (e.g., monoallelic gene expression). In metazoa, this involves the methylation of histone H3K27." [PMID:17936700] | 2 | 0.003264 | 33 |
| GO:BP | GO:0071453 | cellular response to oxygen levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah] | 3 | 0.003723 | 33 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 4 | 0.003769 | 33 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 5 | 0.003944 | 33 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 3 | 0.004598 | 33 |
| GO:BP | GO:0007000 | nucleolus organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] | 2 | 0.004876 | 33 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 5 | 0.005462 | 33 |
| GO:BP | GO:1903376 | regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] | 2 | 0.006810 | 33 |
| GO:BP | GO:0036480 | neuron intrinsic apoptotic signaling pathway in response to oxidative stress | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:PARL, PMID:23858059] | 2 | 0.008279 | 33 |
| GO:BP | GO:0072593 | reactive oxygen species metabolic process | "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [GOC:mah] | 3 | 0.010221 | 33 |
| GO:BP | GO:2001234 | negative regulation of apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 3 | 0.010354 | 33 |
| GO:BP | GO:0043523 | regulation of neuron apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] | 3 | 0.011750 | 33 |
| GO:BP | GO:0034599 | cellular response to oxidative stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] | 3 | 0.012492 | 33 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 5 | 0.013240 | 33 |
| GO:BP | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522] | 2 | 0.015578 | 33 |
| GO:BP | GO:0051402 | neuron apoptotic process | "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis] | 3 | 0.021466 | 33 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 4 | 0.022691 | 33 |
| GO:BP | GO:0001666 | response to hypoxia | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] | 3 | 0.022793 | 33 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 3 | 0.025123 | 33 |
| GO:BP | GO:0036293 | response to decreased oxygen levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] | 3 | 0.026097 | 33 |
| GO:BP | GO:0062197 | cellular response to chemical stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] | 3 | 0.026345 | 33 |
| GO:BP | GO:0062012 | regulation of small molecule metabolic process | "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] | 3 | 0.027097 | 33 |
| GO:BP | GO:0006476 | protein deacetylation | "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] | 2 | 0.030798 | 33 |
| GO:BP | GO:2000378 | negative regulation of reactive oxygen species metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] | 2 | 0.032297 | 33 |
| GO:BP | GO:0070482 | response to oxygen levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] | 3 | 0.033626 | 33 |
| GO:BP | GO:0042304 | regulation of fatty acid biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils." [GOC:go_curators, GOC:jl] | 2 | 0.035402 | 33 |
| GO:BP | GO:0035601 | protein deacylation | "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid." [GOC:se, PMID:12080046] | 2 | 0.043784 | 33 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 5 | 0.044128 | 33 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 3 | 0.045246 | 33 |
| GO:BP | GO:0140719 | constitutive heterochromatin formation | "The compaction of chromatin into heterochromatin, a conformation that is refractory to transcription. Constitutive heterochromatin cannot be converted back to euchromatin, the transcriptionally-active conformation. In metazoa, this involves the methylation of histone H3K9." [PMID:17936700] | 2 | 0.045567 | 33 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 4 | 0.047905 | 33 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 5 | 0.049511 | 33 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005677 | chromatin silencing complex | "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] | 2 | 0.000703 | 33 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 4 | 0.016889 | 33 |
| GO:CC | GO:0000791 | euchromatin | "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156] | 2 | 0.018083 | 33 |
| GO:CC | GO:0000792 | heterochromatin | "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] | 2 | 0.030471 | 33 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3630 | NAD metabolism sirtuins and aging | NAD metabolism sirtuins and aging | 2 | 0.001378 | 33 |
| WP | WP:WP3644 | NAD metabolism | NAD metabolism | 2 | 0.003003 | 33 |
| WP | WP:WP3645 | NAD biosynthetic pathways | NAD biosynthetic pathways | 2 | 0.005774 | 33 |
| WP | WP:WP5046 | NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence | NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence | 2 | 0.005774 | 33 |
| WP | WP:WP3614 | Photodynamic therapy induced HIF 1 survival signaling | Photodynamic therapy induced HIF 1 survival signaling | 2 | 0.016589 | 33 |
| WP | WP:WP4906 | 3q29 copy number variation syndrome | 3q29 copy number variation syndrome | 2 | 0.048358 | 33 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00760 | Nicotinate and nicotinamide metabolism | Nicotinate and nicotinamide metabolism | 2 | 0.008998 | 33 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-448 | hsa-mir-448 | hsa-mir-448 | 4 | 0.015481 | 33 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2592 | SIRT1 homotrimer complex | SIRT1 homotrimer complex | 1 | 0.04968 | 33 |
Community 34
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6812-3p | hsa-mir-6812-3p | hsa-mir-6812-3p | 2 | 0.017603 | 34 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0032311 | angiogenin-PRI complex | "A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis." [PMID:2706246, PMID:3470787] | 1 | 0.049885 | 34 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6170 | Angiogenin-PRI complex | Angiogenin-PRI complex | 1 | 0.049932 | 34 |
Community 35
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1902893 | regulation of miRNA transcription | "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 3 | 0.000023 | 35 |
| GO:BP | GO:0061614 | miRNA transcription | "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799] | 3 | 0.000024 | 35 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 3 | 0.000038 | 35 |
| GO:BP | GO:0010586 | miRNA metabolic process | "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] | 3 | 0.000062 | 35 |
| GO:BP | GO:0035162 | embryonic hemopoiesis | "The stages of blood cell formation that take place within the embryo." [GOC:bf] | 2 | 0.001872 | 35 |
| GO:BP | GO:2000352 | negative regulation of endothelial cell apoptotic process | "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] | 2 | 0.003363 | 35 |
| GO:BP | GO:0048732 | gland development | "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] | 3 | 0.005001 | 35 |
| GO:BP | GO:0001709 | cell fate determination | "The cellular developmental process involved in cell fate commitment that occurs after cell fate specification, in which a cell is irreversibly committed to a cellular developmental fate which is heritable on cell division." [ISBN:0878932437] | 2 | 0.006709 | 35 |
| GO:BP | GO:2000351 | regulation of endothelial cell apoptotic process | "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] | 2 | 0.009695 | 35 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 2 | 0.010812 | 35 |
| GO:BP | GO:0072577 | endothelial cell apoptotic process | "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal." [CL:0000115, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] | 2 | 0.011590 | 35 |
| GO:BP | GO:0030225 | macrophage differentiation | "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149] | 2 | 0.014087 | 35 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 2 | 0.014087 | 35 |
| GO:BP | GO:0010595 | positive regulation of endothelial cell migration | "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] | 2 | 0.038357 | 35 |
| GO:BP | GO:0042472 | inner ear morphogenesis | "The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively." [GOC:jl, ISBN:0192801023] | 2 | 0.041287 | 35 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 3 | 0.044257 | 35 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP236 | Adipogenesis | Adipogenesis | 3 | 0.000209 | 35 |
| WP | WP:WP4211 | Transcriptional cascade regulating adipogenesis | Transcriptional cascade regulating adipogenesis | 2 | 0.000399 | 35 |
| WP | WP:WP5102 | Familial partial lipodystrophy | Familial partial lipodystrophy | 2 | 0.002220 | 35 |
| WP | WP:WP4149 | White fat cell differentiation | White fat cell differentiation | 2 | 0.002531 | 35 |
| WP | WP:WP3527 | Pre implantation embryo | Pre implantation embryo | 2 | 0.008417 | 35 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 3 | 0.001690 | 35 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 3 | 0.004671 | 35 |
| GO:MF | GO:0001223 | transcription coactivator binding | "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] | 2 | 0.005302 | 35 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 3 | 0.008648 | 35 |
| GO:MF | GO:0001221 | transcription coregulator binding | "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] | 2 | 0.033780 | 35 |
Community 36
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4290 | Metabolic reprogramming in colon cancer | Metabolic reprogramming in colon cancer | 2 | 0.011324 | 36 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 4 | 0.011368 | 36 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 4 | 0.012029 | 36 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 4 | 0.012051 | 36 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 4 | 0.012051 | 36 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004333 | fumarate hydratase activity | "Catalysis of the reaction: (S)-malate = fumarate + H2O." [EC:4.2.1.2, RHEA:12460] | 1 | 0.049891 | 36 |
| GO:MF | GO:0016894 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters | "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah] | 1 | 0.049891 | 36 |
Community 37
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5232 | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) | 3 | 0.000012 | 37 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4331 | Neovascularization processes | Neovascularization processes | 2 | 0.003397 | 37 |
| WP | WP:WP5269 | Genetic causes of porto sinusoidal vascular disease | Genetic causes of porto sinusoidal vascular disease | 2 | 0.003397 | 37 |
| WP | WP:WP5144 | NRP1 triggered signaling in pancreatic cancer | NRP1 triggered signaling in pancreatic cancer | 2 | 0.007019 | 37 |
| WP | WP:WP195 | IL1 signaling | IL1 signaling | 2 | 0.007289 | 37 |
| WP | WP:WP2034 | Leptin signaling | Leptin signaling | 2 | 0.012641 | 37 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 2 | 0.013366 | 37 |
| WP | WP:WP69 | T cell receptor signaling | T cell receptor signaling | 2 | 0.014111 | 37 |
| WP | WP:WP4949 | 16p11 2 proximal deletion syndrome | 16p11 2 proximal deletion syndrome | 2 | 0.014492 | 37 |
| WP | WP:WP231 | TNF alpha signaling | TNF alpha signaling | 2 | 0.019892 | 37 |
| WP | WP:WP23 | B cell receptor signaling | B cell receptor signaling | 2 | 0.021259 | 37 |
| WP | WP:WP5475 | Hallmark of cancer sustaining proliferative signaling | Hallmark of cancer sustaining proliferative signaling | 2 | 0.024127 | 37 |
| WP | WP:WP4932 | 7q11 23 copy number variation syndrome | 7q11 23 copy number variation syndrome | 2 | 0.028767 | 37 |
| WP | WP:WP4217 | Ebola virus infection in host | Ebola virus infection in host | 2 | 0.041164 | 37 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0351183 | Pancreas; pancreatic endocrine cells[High] | Pancreas; pancreatic endocrine cells[High] | 3 | 0.02364 | 37 |
Community 38
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity | "Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810] | 2 | 0.000447 | 38 |
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 2 | 0.005533 | 38 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 3 | 0.006951 | 38 |
| GO:MF | GO:0043539 | protein serine/threonine kinase activator activity | "Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators] | 2 | 0.011499 | 38 |
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 2 | 0.013236 | 38 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 2 | 0.013236 | 38 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 3 | 0.019563 | 38 |
| GO:MF | GO:0043130 | ubiquitin binding | "Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd] | 2 | 0.024237 | 38 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 3 | 0.029976 | 38 |
| GO:MF | GO:0032182 | ubiquitin-like protein binding | "Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah] | 2 | 0.034356 | 38 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 3 | 0.040321 | 38 |
| GO:MF | GO:0030295 | protein kinase activator activity | "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] | 2 | 0.043583 | 38 |
| GO:MF | GO:0019209 | kinase activator activity | "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] | 2 | 0.048950 | 38 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 3 | 0.004188 | 38 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 3 | 0.006368 | 38 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 3 | 0.008055 | 38 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 0.022155 | 38 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 3 | 0.038053 | 38 |
| GO:BP | GO:0048144 | fibroblast proliferation | "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] | 2 | 0.039808 | 38 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0019005 | SCF ubiquitin ligase complex | "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] | 2 | 0.004685 | 38 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 2 | 0.005130 | 38 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 2 | 0.021554 | 38 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 2 | 0.026121 | 38 |
| GO:CC | GO:0031461 | cullin-RING ubiquitin ligase complex | "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] | 2 | 0.040289 | 38 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0510113 | Soft tissue 2; chondrocytes[High] | Soft tissue 2; chondrocytes[High] | 2 | 0.017080 | 38 |
| HPA | HPA:0500703 | Soft tissue 1; peripheral nerve[High] | Soft tissue 1; peripheral nerve[High] | 2 | 0.031356 | 38 |
| HPA | HPA:0510703 | Soft tissue 2; peripheral nerve[High] | Soft tissue 2; peripheral nerve[High] | 2 | 0.046382 | 38 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 2 | 0.017154 | 38 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 2 | 0.02267 | 38 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5319 | CDH1-CKS1B complex | CDH1-CKS1B complex | 1 | 0.024966 | 38 |
Community 39
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043484 | regulation of RNA splicing | "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] | 3 | 0.001834 | 39 |
Community 40
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0170034 | L-amino acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of L-amino acids, the L-enantiomers of amino acids." [GOC:edw] | 2 | 0.024857 | 40 |
| GO:BP | GO:0170038 | proteinogenic amino acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew] | 2 | 0.027773 | 40 |
| GO:BP | GO:1901607 | alpha-amino acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie] | 2 | 0.041052 | 40 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004587 | ornithine aminotransferase activity | "Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde." [EC:2.6.1.13] | 1 | 0.049891 | 40 |
| GO:MF | GO:0004617 | phosphoglycerate dehydrogenase activity | "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] | 1 | 0.049891 | 40 |
Community 41
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 3 | 0.000226 | 41 |
| GO:MF | GO:0004386 | helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] | 3 | 0.000477 | 41 |
| GO:MF | GO:0120545 | nucleic acid conformation isomerase activity | "Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-] | 3 | 0.000574 | 41 |
| GO:MF | GO:0140097 | catalytic activity, acting on DNA | "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] | 3 | 0.002095 | 41 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 3 | 0.002907 | 41 |
| GO:MF | GO:0016853 | isomerase activity | "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] | 3 | 0.010981 | 41 |
| GO:MF | GO:0003678 | DNA helicase activity | "Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl] | 2 | 0.012602 | 41 |
| GO:MF | GO:0004527 | exonuclease activity | "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] | 2 | 0.027503 | 41 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 3 | 0.029034 | 41 |
| GO:MF | GO:0140640 | catalytic activity, acting on a nucleic acid | "Catalytic activity that acts to modify a nucleic acid." [GOC:pg] | 3 | 0.031740 | 41 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2942 | DDX1 as a regulatory component of the Drosha microprocessor | DDX1 as a regulatory component of the Drosha microprocessor | 2 | 0.000278 | 41 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:433 | BASC complex (BRCA1-associated genome surveillance complex) | BASC complex (BRCA1-associated genome surveillance complex) | 2 | 0.001947 | 41 |
| CORUM | CORUM:1132 | RFC2-RIalpha complex | RFC2-RIalpha complex | 1 | 0.049988 | 41 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | Impaired BRCA2 binding to RAD51 | 2 | 0.005389 | 41 |
| REAC | REAC:R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | HDR through Single Strand Annealing (SSA) | 2 | 0.006032 | 41 |
| REAC | REAC:R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | Presynaptic phase of homologous DNA pairing and strand exchange | 2 | 0.007063 | 41 |
| REAC | REAC:R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | Diseases of DNA Double-Strand Break Repair | 2 | 0.007425 | 41 |
| REAC | REAC:R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2 | 0.007425 | 41 |
| REAC | REAC:R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | Homologous DNA Pairing and Strand Exchange | 2 | 0.008175 | 41 |
| REAC | REAC:R-HSA-9675135 | Diseases of DNA repair | Diseases of DNA repair | 2 | 0.011086 | 41 |
| REAC | REAC:R-HSA-5685942 | HDR through Homologous Recombination (HRR) | HDR through Homologous Recombination (HRR) | 2 | 0.021828 | 41 |
| REAC | REAC:R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Regulation of TP53 Activity through Phosphorylation | 2 | 0.037785 | 41 |
| REAC | REAC:R-HSA-69473 | G2/M DNA damage checkpoint | G2/M DNA damage checkpoint | 2 | 0.039450 | 41 |
| REAC | REAC:R-HSA-5693607 | Processing of DNA double-strand break ends | Processing of DNA double-strand break ends | 2 | 0.042015 | 41 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 2 | 0.009335 | 41 |
| GO:CC | GO:0071920 | cleavage body | "A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing." [PMID:10564273, PMID:11598190, PMID:8654386] | 1 | 0.049885 | 41 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0022616 | DNA strand elongation | "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:isa_complete, GOC:mah] | 2 | 0.012026 | 41 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 4 | 0.038140 | 41 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0100953 | Enlarged interhemispheric fissure | Enlarged interhemispheric fissure | 1 | 0.049962 | 41 |
Community 42
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0271113 | Kidney; bowman's capsule[High] | Kidney; bowman's capsule[High] | 2 | 0.020796 | 42 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000417 | HIR complex | "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700] | 1 | 0.02499 | 42 |
Community 43
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 3 | 0.000073 | 43 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 3 | 0.000073 | 43 |
| GO:CC | GO:0005788 | endoplasmic reticulum lumen | "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] | 3 | 0.001528 | 43 |
| GO:CC | GO:0140534 | endoplasmic reticulum protein-containing complex | "A protein complex that is part of an endoplasmic reticulum." [GOC:pg] | 2 | 0.022382 | 43 |
| GO:CC | GO:0016222 | procollagen-proline 4-dioxygenase complex | "A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase." [PMID:14500733, PMID:7753822] | 1 | 0.049885 | 43 |
| GO:CC | GO:0017177 | glucosidase II complex | "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335] | 1 | 0.049885 | 43 |
| GO:CC | GO:1902687 | glucosidase complex | "A protein complex which is capable of glucosidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23826932] | 1 | 0.049885 | 43 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 4 | 0.001171 | 43 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 4 | 0.002460 | 43 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 4 | 0.003018 | 43 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 4 | 0.027372 | 43 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4254 | hsa-mir-4254 | hsa-mir-4254 | 4 | 0.015961 | 43 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9020591 | Interleukin-12 signaling | Interleukin-12 signaling | 2 | 0.018843 | 43 |
| REAC | REAC:R-HSA-447115 | Interleukin-12 family signaling | Interleukin-12 family signaling | 2 | 0.027580 | 43 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:472 | Prolyl 4-hydroxylase (alpha(I)-type) | Prolyl 4-hydroxylase (alpha(I)-type) | 1 | 0.024966 | 43 |
| CORUM | CORUM:474 | Prolyl 4-hydroxylase (alpha(III)-type) | Prolyl 4-hydroxylase (alpha(III)-type) | 1 | 0.049932 | 43 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0033919 | glucan 1,3-alpha-glucosidase activity | "Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans." [EC:3.2.1.84] | 1 | 0.049891 | 43 |
Community 44
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0031492 | nucleosomal DNA binding | "Binding to the DNA portion of a nucleosome." [GOC:mah] | 2 | 0.005449 | 44 |
| GO:MF | GO:0031491 | nucleosome binding | "Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah] | 2 | 0.012199 | 44 |
| GO:MF | GO:0031490 | chromatin DNA binding | "Binding to DNA that is assembled into chromatin." [GOC:mah] | 2 | 0.027539 | 44 |
Community 45
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0005007 | fibroblast growth factor receptor activity | "Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] | 2 | 0.000074 | 45 |
| GO:MF | GO:0017134 | fibroblast growth factor binding | "Binding to a fibroblast growth factor." [PMID:9806903] | 2 | 0.001868 | 45 |
| GO:MF | GO:0004714 | transmembrane receptor protein tyrosine kinase activity | "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] | 2 | 0.023829 | 45 |
| GO:MF | GO:0019199 | transmembrane receptor protein kinase activity | "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:mah] | 2 | 0.036360 | 45 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 2 | 0.046442 | 45 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4808 | Endochondral ossification with skeletal dysplasias | Endochondral ossification with skeletal dysplasias | 3 | 0.000119 | 45 |
| WP | WP:WP474 | Endochondral ossification | Endochondral ossification | 3 | 0.000119 | 45 |
| WP | WP:WP5055 | Burn wound healing | Burn wound healing | 3 | 0.000203 | 45 |
| WP | WP:WP5312 | Metabolic pathways of fibroblasts | Metabolic pathways of fibroblasts | 2 | 0.006534 | 45 |
| WP | WP:WP5373 | Osteoarthritic chondrocyte hypertrophy | Osteoarthritic chondrocyte hypertrophy | 2 | 0.016092 | 45 |
| WP | WP:WP4155 | Endometrial cancer | Endometrial cancer | 2 | 0.025605 | 45 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 2 | 0.035352 | 45 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002062 | chondrocyte differentiation | "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] | 3 | 0.000494 | 45 |
| GO:BP | GO:0010518 | positive regulation of phospholipase activity | "Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] | 2 | 0.001194 | 45 |
| GO:BP | GO:0051216 | cartilage development | "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:cjm, PMID:23251424] | 3 | 0.002713 | 45 |
| GO:BP | GO:0010517 | regulation of phospholipase activity | "Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] | 2 | 0.002766 | 45 |
| GO:BP | GO:0048705 | skeletal system morphogenesis | "The process in which the anatomical structures of the skeleton are generated and organized." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb] | 3 | 0.003646 | 45 |
| GO:BP | GO:0060193 | positive regulation of lipase activity | "Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:BHF, GOC:dph, GOC:tb] | 2 | 0.004175 | 45 |
| GO:BP | GO:0061448 | connective tissue development | "The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF] | 3 | 0.006997 | 45 |
| GO:BP | GO:0060350 | endochondral bone morphogenesis | "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679] | 2 | 0.032993 | 45 |
| GO:BP | GO:0001501 | skeletal system development | "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb] | 3 | 0.044068 | 45 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002761 | Generalized joint hypermobility | Joint hypermobility (ability of a joint to move beyond its normal range of motion) affecting many or all joints of the body. In individuals with Joint hypermobility at multiple sites (usually five or more), the term generalized joint hypermobility is preferred. | 3 | 0.002713 | 45 |
| HP | HP:0003795 | Short middle phalanx of toe | Developmental hypoplasia (shortening) of middle phalanx of toe. | 2 | 0.004006 | 45 |
| HP | HP:0008905 | Rhizomelia | Disproportionate shortening of the proximal segment of limbs (i.e. the femur and humerus). | 3 | 0.007493 | 45 |
| HP | HP:0002676 | Cloverleaf skull | Trilobar skull configuration when viewed from the front or behind. | 2 | 0.011209 | 45 |
| HP | HP:0010053 | Abnormality of the distal phalanx of the hallux | Abnormality of the distal phalanx of the hallux | 2 | 0.026393 | 45 |
| HP | HP:0010183 | Abnormality of the middle phalanges of the toes | Abnormality of the middle phalanges of the toes | 2 | 0.026393 | 45 |
| HP | HP:0010502 | Fibular bowing | A bending or abnormal curvature of the fibula. | 2 | 0.026393 | 45 |
| HP | HP:0008873 | Disproportionate short-limb short stature | A type of disproportionate short stature characterized by a short limbs but an average-sized trunk. | 3 | 0.033542 | 45 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | Central carbon metabolism in cancer | 2 | 0.009914 | 45 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | Signaling pathways regulating pluripotency of stem cells | 2 | 0.041439 | 45 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1226099 | Signaling by FGFR in disease | Signaling by FGFR in disease | 2 | 0.025701 | 45 |
Community 46
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 2 | 0.005130 | 46 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 2 | 0.021554 | 46 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 2 | 0.026121 | 46 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 2 | 0.013236 | 46 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 2 | 0.013236 | 46 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 3 | 0.019563 | 46 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 3 | 0.029976 | 46 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 3 | 0.040321 | 46 |
| GO:MF | GO:0030295 | protein kinase activator activity | "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] | 2 | 0.043583 | 46 |
| GO:MF | GO:0019209 | kinase activator activity | "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] | 2 | 0.048950 | 46 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] | 2 | 0.021391 | 46 |
Community 47
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0010730 | Double eyebrow | This may present as a partial or complete duplication of the eyebrows. | 1 | 0.049962 | 47 |
Community 48
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051299 | centrosome separation | "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai] | 2 | 0.000814 | 48 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 3 | 0.004247 | 48 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | TP53 Regulates Transcription of Cell Cycle Genes | 2 | 0.005337 | 48 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005814 | centriole | "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] | 2 | 0.029287 | 48 |
Community 49
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2005 | miR targeted genes in muscle cell | miR targeted genes in muscle cell | 3 | 0.004140 | 49 |
| WP | WP:WP2004 | miR targeted genes in lymphocytes | miR targeted genes in lymphocytes | 3 | 0.007216 | 49 |
| WP | WP:WP2003 | miR targeted genes in leukocytes | miR targeted genes in leukocytes | 2 | 0.039259 | 49 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0086039 | P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential | "A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 1 | 0.049724 | 49 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0008410 | Subungual hyperkeratotic fragments | Subungual hyperkeratotic fragments | 1 | 0.049962 | 49 |
| HP | HP:0025512 | Skin-colored papule | A papule with the same color as the surrounding skin. | 1 | 0.049962 | 49 |
| HP | HP:6001074 | Longitudinal erythronychia | A longitudinal red band extending from the proximal nail fold or lunula to the distal nail plate. | 1 | 0.049962 | 49 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0014801 | longitudinal sarcoplasmic reticulum | "The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae." [GOC:mtg_muscle] | 1 | 0.049978 | 49 |
| GO:CC | GO:0090534 | calcium ion-transporting ATPase complex | "Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in)." [GOC:BHF] | 1 | 0.049978 | 49 |
Community 50
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0035145 | exon-exon junction complex | "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026] | 2 | 0.000474 | 50 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0090183 | Cerebellum; cells in granular layer[High] | Cerebellum; cells in granular layer[High] | 3 | 0.019718 | 50 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 3 | 0.035470 | 50 |
Community 51
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 3 | 0.012755 | 51 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016746 | acyltransferase activity | "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [EC:2.3.-.-] | 3 | 0.018971 | 51 |
| GO:MF | GO:0061656 | SUMO conjugating enzyme activity | "Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue." [GOC:dph] | 1 | 0.049724 | 51 |
| GO:MF | GO:0106075 | peptide N-succinyltransferase activity | "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide." [PMID:29211711] | 1 | 0.049724 | 51 |
| GO:MF | GO:0106078 | histone succinyltransferase activity | "Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone." [PMID:29211711] | 1 | 0.049724 | 51 |
| GO:MF | GO:0106228 | peptide glutaryltransferase activity | "Catalysis of the reaction: glutaryl-CoA + L-lysyl-[protein] = CoA + H+ + N6-glutaryl-L-lysyl-[protein]." [GOC:sp, PMID:31542297] | 1 | 0.049724 | 51 |
| GO:MF | GO:0106229 | histone glutaryltransferase activity | "Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone." [GOC:sp, PMID:31542297] | 1 | 0.049724 | 51 |
Community 52
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1183 | CDC5L complex | CDC5L complex | 2 | 0.009562 | 52 |
Community 53
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6990 | THSD1-FAK-talin-vinculin complex | THSD1-FAK-talin-vinculin complex | 2 | 0.000177 | 53 |
| CORUM | CORUM:5177 | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) | 2 | 0.000620 | 53 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 3 | 0.001438 | 53 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 3 | 0.001493 | 53 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 3 | 0.004304 | 53 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 3 | 0.004625 | 53 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 3 | 0.008654 | 53 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 3 | 0.009495 | 53 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 3 | 0.011778 | 53 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 3 | 0.011834 | 53 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 3 | 0.011946 | 53 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 3 | 0.012343 | 53 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 3 | 0.012632 | 53 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 3 | 0.015576 | 53 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 3 | 0.016533 | 53 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 3 | 0.017313 | 53 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 3 | 0.019640 | 53 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 3 | 0.023288 | 53 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 3 | 0.023552 | 53 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 3 | 0.026397 | 53 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 3 | 0.027167 | 53 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 3 | 0.030186 | 53 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 3 | 0.031240 | 53 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 3 | 0.031669 | 53 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 3 | 0.031884 | 53 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 3 | 0.031993 | 53 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 3 | 0.040697 | 53 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 3 | 0.048671 | 53 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | Signaling by high-kinase activity BRAF mutants | 2 | 0.005389 | 53 |
| REAC | REAC:R-HSA-5674135 | MAP2K and MAPK activation | MAP2K and MAPK activation | 2 | 0.006710 | 53 |
| REAC | REAC:R-HSA-9656223 | Signaling by RAF1 mutants | Signaling by RAF1 mutants | 2 | 0.007063 | 53 |
| REAC | REAC:R-HSA-445355 | Smooth Muscle Contraction | Smooth Muscle Contraction | 2 | 0.008175 | 53 |
| REAC | REAC:R-HSA-6802949 | Signaling by RAS mutants | Signaling by RAS mutants | 2 | 0.008962 | 53 |
| REAC | REAC:R-HSA-9649948 | Signaling downstream of RAS mutants | Signaling downstream of RAS mutants | 2 | 0.008962 | 53 |
| REAC | REAC:R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2 | 0.008962 | 53 |
| REAC | REAC:R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | Signaling by moderate kinase activity BRAF mutants | 2 | 0.008962 | 53 |
| REAC | REAC:R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | Signaling by BRAF and RAF1 fusions | 2 | 0.018229 | 53 |
| REAC | REAC:R-HSA-6802957 | Oncogenic MAPK signaling | Oncogenic MAPK signaling | 2 | 0.029995 | 53 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M07253 | Factor: ERR2; motif: NTGACCTTGA | Factor: ERR2; motif: NTGACCTTGA | 3 | 0.009462 | 53 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2572 | Primary focal segmental glomerulosclerosis FSGS | Primary focal segmental glomerulosclerosis FSGS | 2 | 0.013001 | 53 |
| WP | WP:WP185 | Integrin mediated cell adhesion | Integrin mediated cell adhesion | 2 | 0.025629 | 53 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051893 | regulation of focal adhesion assembly | "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai] | 2 | 0.013228 | 53 |
| GO:BP | GO:0090109 | regulation of cell-substrate junction assembly | "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb] | 2 | 0.013228 | 53 |
| GO:BP | GO:0150116 | regulation of cell-substrate junction organization | "Any process that modulates the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] | 2 | 0.015427 | 53 |
| GO:BP | GO:0070527 | platelet aggregation | "The adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF, GOC:vk] | 2 | 0.019295 | 53 |
| GO:BP | GO:0048041 | focal adhesion assembly | "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jid, GOC:mah] | 2 | 0.024163 | 53 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] | 2 | 0.030853 | 53 |
| GO:BP | GO:0034109 | homotypic cell-cell adhesion | "The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add] | 2 | 0.034845 | 53 |
| GO:BP | GO:0150115 | cell-substrate junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 2 | 0.035534 | 53 |
| GO:BP | GO:0001952 | regulation of cell-matrix adhesion | "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd] | 2 | 0.049899 | 53 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0090636 | outer dense plaque of desmosome | "The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins, as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane." [PMID:20066089] | 1 | 0.024990 | 53 |
| GO:CC | GO:0061826 | podosome ring | "The ring structure surrounding the podosome core, containing proteins such as vinculin and talin." [PMID:23158496] | 1 | 0.024990 | 53 |
| GO:CC | GO:0090637 | inner dense plaque of desmosome | "The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane." [PMID:20066089] | 1 | 0.024990 | 53 |
| GO:CC | GO:0005912 | adherens junction | "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264] | 2 | 0.039866 | 53 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 3 | 0.040442 | 53 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034313 | Hyperdynamic left ventricular ejection fraction | An abnormally increased ejection fraction of the left ventricle, usually defined as a left ventricular ejection fraction greater than 70 percent. | 1 | 0.049962 | 53 |
Community 55
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 3 | 0.040008 | 55 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6562 | RAB11B-SPG33 complex | RAB11B-SPG33 complex | 1 | 0.049932 | 55 |
Community 56
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-4341670 | Defective NEU1 causes sialidosis | Defective NEU1 causes sialidosis | 2 | 0.000027 | 56 |
| REAC | REAC:R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | Diseases associated with N-glycosylation of proteins | 2 | 0.001723 | 56 |
| REAC | REAC:R-HSA-4085001 | Sialic acid metabolism | Sialic acid metabolism | 2 | 0.004783 | 56 |
| REAC | REAC:R-HSA-9840310 | Glycosphingolipid catabolism | Glycosphingolipid catabolism | 2 | 0.005706 | 56 |
| REAC | REAC:R-HSA-1660662 | Glycosphingolipid metabolism | Glycosphingolipid metabolism | 2 | 0.013435 | 56 |
| REAC | REAC:R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | Synthesis of substrates in N-glycan biosythesis | 2 | 0.017660 | 56 |
| REAC | REAC:R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | 2 | 0.027130 | 56 |
| REAC | REAC:R-HSA-428157 | Sphingolipid metabolism | Sphingolipid metabolism | 2 | 0.046467 | 56 |
| REAC | REAC:R-HSA-2206308 | MPS IV - Morquio syndrome B | MPS IV - Morquio syndrome B | 1 | 0.049932 | 56 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0008166 | Decreased beta-galactosidase activity | Abnormally decreased rate of beta-galactosidase activity. Beta-galactosidase activity can be measured in leukocyte, fibroblast, or plasma. | 2 | 0.000498 | 56 |
| HP | HP:0004342 | Abnormal galactosidase enyzme activity | Abnormality of galactoside metabolism. A galactoside is a glycoside (a sugar moiety bound to some other moiety) containing galactose. | 2 | 0.000498 | 56 |
| HP | HP:0003649 | Abnormal glycosidase enzyme activity | Abnormality of glycosidase enzyme activity. Glycoside hydrolases (GHs), including glycosidases and transglycosidases. These enzymes constitute 113 protein families that are responsible for the hydrolysis and/or transglycosylation of glycosidic bonds. | 2 | 0.000498 | 56 |
| HP | HP:0010729 | Cherry red spot of the macula | Pallor of the perifoveal macula of the retina with appearance of a small circular reddish choroid shape as seen through the fovea centralis due to relative transparency of the macula. | 2 | 0.012937 | 56 |
| HP | HP:0000943 | Dysostosis multiplex | Dysostosis multiplex | 2 | 0.041909 | 56 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04142 | Lysosome | Lysosome | 2 | 0.00626 | 56 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0035578 | azurophil granule lumen | "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] | 2 | 0.009216 | 56 |
| GO:CC | GO:0043202 | lysosomal lumen | "The volume enclosed within the lysosomal membrane." [GOC:jl, PMID:15213228] | 2 | 0.011137 | 56 |
| GO:CC | GO:0005766 | primary lysosome | "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] | 2 | 0.026809 | 56 |
| GO:CC | GO:0042582 | azurophil granule | "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule] | 2 | 0.026809 | 56 |
| GO:CC | GO:0005775 | vacuolar lumen | "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] | 2 | 0.036160 | 56 |
| GO:CC | GO:0098575 | lumenal side of lysosomal membrane | "The side (leaflet) of the lysosomal membrane that faces the lumen." [GOC:dos] | 1 | 0.049978 | 56 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2858 | Ectoderm differentiation | Ectoderm differentiation | 2 | 0.049937 | 56 |
Community 58
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0090307 | mitotic spindle assembly | "Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw] | 2 | 0.019295 | 58 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990811 | MWP complex | "A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin." [PMID:25987607, PMID:29021344] | 1 | 0.02499 | 58 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5241 | SMC1-SMC3 complex | SMC1-SMC3 complex | 1 | 0.049932 | 58 |
Community 59
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0070530 | K63-linked polyubiquitin modification-dependent protein binding | "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein." [GOC:mah, PMID:15556404, PMID:17525341] | 2 | 0.001473 | 59 |
| GO:MF | GO:0031593 | polyubiquitin modification-dependent protein binding | "Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg] | 2 | 0.008105 | 59 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | TNFR1-induced NF-kappa-B signaling pathway | 2 | 0.004783 | 59 |
| REAC | REAC:R-HSA-5357905 | Regulation of TNFR1 signaling | Regulation of TNFR1 signaling | 2 | 0.009369 | 59 |
| REAC | REAC:R-HSA-75893 | TNF signaling | TNF signaling | 2 | 0.013435 | 59 |
| REAC | REAC:R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | Toll Like Receptor 3 (TLR3) Cascade | 2 | 0.047385 | 59 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0016239 | positive regulation of macroautophagy | "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] | 2 | 0.025907 | 59 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2123 | IKBKG homodimer complex | IKBKG homodimer complex | 1 | 0.049932 | 59 |
| CORUM | CORUM:5730 | IKBKG homotrimer complex | IKBKG homotrimer complex | 1 | 0.049932 | 59 |
| CORUM | CORUM:5827 | IKBKG homotetramer complex | IKBKG homotetramer complex | 1 | 0.049932 | 59 |
Community 60
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] | 2 | 0.021391 | 60 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12041_1 | Factor: TEF-1; motif: CRCATWCCN; match class: 1 | Factor: TEF-1; motif: CRCATWCCN; match class: 1 | 3 | 0.022856 | 60 |
| TF | TF:M10093_1 | Factor: TEF-3; motif: RCATTCCWGNNNN; match class: 1 | Factor: TEF-3; motif: RCATTCCWGNNNN; match class: 1 | 2 | 0.045437 | 60 |
Community 61
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0060020 | Bergmann glial cell differentiation | "The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, PMID:10375501] | 2 | 0.000373 | 61 |
| GO:BP | GO:0014002 | astrocyte development | "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:dgh, GOC:ef] | 2 | 0.005836 | 61 |
| GO:BP | GO:0045109 | intermediate filament organization | "Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:ai] | 2 | 0.017794 | 61 |
| GO:BP | GO:0048708 | astrocyte differentiation | "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:vp, PMID:15139015] | 2 | 0.024738 | 61 |
| GO:BP | GO:0045104 | intermediate filament cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai] | 2 | 0.029576 | 61 |
| GO:BP | GO:0045103 | intermediate filament-based process | "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins." [GOC:ai] | 2 | 0.030211 | 61 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9613829 | Chaperone Mediated Autophagy | Chaperone Mediated Autophagy | 2 | 0.001048 | 61 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0005200 | structural constituent of cytoskeleton | "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] | 2 | 0.031523 | 61 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2431 | Spinal cord injury | Spinal cord injury | 2 | 0.033231 | 61 |
Community 62
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-3976 | hsa-mir-3976 | hsa-mir-3976 | 3 | 0.021986 | 62 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004725 | protein tyrosine phosphatase activity | "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] | 2 | 0.026221 | 62 |
| GO:MF | GO:0004638 | phosphoribosylaminoimidazole carboxylase activity | "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2." [EC:4.1.1.21, RHEA:10792] | 1 | 0.049724 | 62 |
| GO:MF | GO:0004639 | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate." [EC:6.3.2.6, RHEA:22628] | 1 | 0.049724 | 62 |
Community 63
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0016460 | myosin II complex | "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin] | 2 | 0.000791 | 63 |
| GO:CC | GO:0016459 | myosin complex | "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin] | 2 | 0.003724 | 63 |
| GO:CC | GO:0005903 | brush border | "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] | 2 | 0.013485 | 63 |
| GO:CC | GO:0098862 | cluster of actin-based cell projections | "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos] | 2 | 0.033016 | 63 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5627117 | RHO GTPases Activate ROCKs | RHO GTPases Activate ROCKs | 2 | 0.001550 | 63 |
| REAC | REAC:R-HSA-5625900 | RHO GTPases activate CIT | RHO GTPases activate CIT | 2 | 0.001550 | 63 |
| REAC | REAC:R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | Sema4D induced cell migration and growth-cone collapse | 2 | 0.001723 | 63 |
| REAC | REAC:R-HSA-5627123 | RHO GTPases activate PAKs | RHO GTPases activate PAKs | 2 | 0.001904 | 63 |
| REAC | REAC:R-HSA-400685 | Sema4D in semaphorin signaling | Sema4D in semaphorin signaling | 2 | 0.002502 | 63 |
| REAC | REAC:R-HSA-3928663 | EPHA-mediated growth cone collapse | EPHA-mediated growth cone collapse | 2 | 0.003425 | 63 |
| REAC | REAC:R-HSA-445355 | Smooth Muscle Contraction | Smooth Muscle Contraction | 2 | 0.008175 | 63 |
| REAC | REAC:R-HSA-373755 | Semaphorin interactions | Semaphorin interactions | 2 | 0.018229 | 63 |
| REAC | REAC:R-HSA-2682334 | EPH-Ephrin signaling | EPH-Ephrin signaling | 2 | 0.036156 | 63 |
| REAC | REAC:R-HSA-5625740 | RHO GTPases activate PKNs | RHO GTPases activate PKNs | 2 | 0.038613 | 63 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04530 | Tight junction | Tight junction | 2 | 0.010561 | 63 |
| KEGG | KEGG:04814 | Motor proteins | Motor proteins | 2 | 0.013621 | 63 |
Community 64
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0001181 | RNA polymerase I general transcription initiation factor activity | "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs." [GOC:txnOH-2018, PMID:11500378, PMID:17972917, PMID:25346433, PMID:28340337, PMID:28842442, PMID:31358304] | 2 | 0.000049 | 64 |
| GO:MF | GO:0001163 | RNA polymerase I transcription regulatory region sequence-specific DNA binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH] | 2 | 0.000177 | 64 |
| GO:MF | GO:0001164 | RNA polymerase I core promoter sequence-specific DNA binding | "Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] | 2 | 0.000177 | 64 |
| GO:MF | GO:0001046 | core promoter sequence-specific DNA binding | "Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH] | 2 | 0.004224 | 64 |
| GO:MF | GO:0140223 | general transcription initiation factor activity | "A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018] | 2 | 0.009271 | 64 |
| GO:MF | GO:0001165 | RNA polymerase I cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element)." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] | 1 | 0.049724 | 64 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0001188 | RNA polymerase I preinitiation complex assembly | "The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which includes including UBF, SL1, RRN3 and TBP in human). The PIC engages RNA polymerase I on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH, PMID:14969726] | 2 | 0.000305 | 64 |
| GO:BP | GO:0006361 | transcription initiation at RNA polymerase I promoter | "A transcription initiation process that takes place at a RNA polymerase I gene promoter. Ribosomal RNAs (rRNA) genes are transcribed by RNA polymerase I." [GOC:txnOH] | 2 | 0.000529 | 64 |
| GO:BP | GO:0065004 | protein-DNA complex assembly | "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] | 3 | 0.000744 | 64 |
| GO:BP | GO:0071824 | protein-DNA complex organization | "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." [GOC:mah] | 3 | 0.000956 | 64 |
| GO:BP | GO:0006360 | transcription by RNA polymerase I | "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] | 2 | 0.016827 | 64 |
| GO:BP | GO:0070897 | transcription preinitiation complex assembly | "The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH] | 2 | 0.022480 | 64 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-73762 | RNA Polymerase I Transcription Initiation | RNA Polymerase I Transcription Initiation | 2 | 0.009784 | 64 |
| REAC | REAC:R-HSA-73772 | RNA Polymerase I Promoter Escape | RNA Polymerase I Promoter Escape | 2 | 0.036156 | 64 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 3 | 0.043826 | 64 |
Community 65
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0001651 | dense fibrillar component | "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561] | 1 | 0.02499 | 65 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0034512 | box C/D sno(s)RNA binding | "Binding to a box C/D small nucleolar RNA." [GOC:mah] | 1 | 0.049724 | 65 |
Community 66
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6118 | Hook1-Vps39 complex | Hook1-Vps39 complex | 1 | 0.049932 | 66 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1902500 | vacuolar HOPS complex | "Any HOPS complex that is part of a vacuolar membrane." [GOC:TermGenie, PMID:23645161] | 1 | 0.049978 | 66 |
| GO:CC | GO:1902501 | lysosomal HOPS complex | "Any HOPS complex that is part of a lysosomal membrane." [GOC:TermGenie, PMID:23645161] | 1 | 0.049978 | 66 |
Community 67
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-3529 | hsa-mir-3529 | hsa-mir-3529 | 3 | 0.010054 | 67 |
| MIRNA | MIRNA:hsa-mir-379 | hsa-mir-379 | hsa-mir-379 | 3 | 0.010054 | 67 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04520 | Adherens junction | Adherens junction | 2 | 0.01753 | 67 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0004914 | Recurrent infantile hypoglycemia | Recurrent episodes of decreased concentration of glucose in the blood occurring during the infantile period. | 1 | 0.049962 | 67 |
| HP | HP:0012686 | Increased pineal volume | An abnormal elevation in the quantity of three-dimensional space taken up by the pineal gland. | 1 | 0.049962 | 67 |
| HP | HP:0034384 | Elevated circulating insulin:C-peptide ratio | Increased ratio of insulin to C-peptide in the blood circulation. | 1 | 0.049962 | 67 |
Community 68
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0031574 | Orbital cleft | A facial cleft characterized by involvement of the orbit. | 1 | 0.049962 | 68 |
| HP | HP:0031576 | Tessier number 4 facial cleft | The cleft lip is midway between the philtral ridge and the commissure of the mouth. The cleft is lateral to the normally shaped and placed nasal ala and passes onto the cheek. The cleft extends through the lower eyelid lateral to the punctum. The lacrimal system and inner canthus are normal. Microphthalmia may be present. The alveolar cleft passes between the lateral incisor and canine, as in the Number 3 cleft. The cleft passes around the pyriform aperture and continues through the portion of the maxillary sinus medial to the infraorbital foramen. The cleft terminates at the medial end of the inferior orbital rim. There is severe vertical soft tissue deficiency in a Number 4 cleft, with the medial margins of the cleft lip extending directly into the medially placed cleft of the lower eyelid. Within the medial segment of the right-sided cleft lip, muscle elements are apparently absent. Muscle bunching is noted in the ipsilateral lateral lip segment, as is seen in a typical unilateral cleft lip. The anatomically normal nasal ala is superiorly displaced in association with a severe deficiency in the overall nasal length. Marked dystopia of the right globe results in its inferior displacement into the medially deficient orbital floor and inferior rim. Both globes are otherwise normal. The complete palatal cleft passes through the maxilla medial to the infraorbital foramen and extends to the medial portion of the inferior orbital rim without evidence of an intact maxillary sinus. Bony septation persists medially, thereby separating the nasal cavity from the orbit, maxillary sinus, and mouth, which are contiguous. Marked midfacial hypoplasia is present. The cleft is manifest as asymmetry of the body of the sphenoid; it is smaller on the right, with asymmetric placement of the pterygoid plates relative to the midline. The orbital floor cleft has no communication with the inferior orbital fissure. The cleft does not extend to the skull base, but there is marked facial asymmetry associated with plagiocephaly. | 1 | 0.049962 | 68 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990723 | cytoplasmic periphery of the nuclear pore complex | "Cytoplasm situated in close proximity to a nuclear pore complex." [PMID:9398662] | 1 | 0.049978 | 68 |
Community 69
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030137 | COPI-coated vesicle | "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894] | 2 | 0.000677 | 69 |
| GO:CC | GO:0005798 | Golgi-associated vesicle | "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] | 2 | 0.010261 | 69 |
| GO:CC | GO:0005789 | endoplasmic reticulum membrane | "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] | 3 | 0.031756 | 69 |
| GO:CC | GO:0098827 | endoplasmic reticulum subcompartment | "A distinct region of the endoplasmic reticulum." [GOC:dos] | 3 | 0.032222 | 69 |
| GO:CC | GO:0042175 | nuclear outer membrane-endoplasmic reticulum membrane network | "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] | 3 | 0.033729 | 69 |
| GO:CC | GO:0030662 | coated vesicle membrane | "The lipid bilayer surrounding a coated vesicle." [GOC:mah] | 2 | 0.044640 | 69 |
| GO:CC | GO:0098796 | membrane protein complex | "Any protein complex that is part of a membrane." [GOC:dos] | 3 | 0.045805 | 69 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524] | 2 | 0.003372 | 69 |
| GO:BP | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] | 2 | 0.021631 | 69 |
| GO:BP | GO:0106273 | cytosol to ERGIC protein transport | "The directed movement of proteins from the cystosol to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC)." [PMID:32272059] | 1 | 0.049542 | 69 |
| GO:BP | GO:0106272 | protein localization to ERGIC | "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum-Golgi intermediate compartment (ERGIC)." [PMID:32272059] | 1 | 0.049542 | 69 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 3 | 0.008654 | 69 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 3 | 0.015576 | 69 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 3 | 0.016533 | 69 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 3 | 0.026397 | 69 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 3 | 0.031240 | 69 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 3 | 0.031669 | 69 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 3 | 0.048671 | 69 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | COPI-dependent Golgi-to-ER retrograde traffic | 2 | 0.043769 | 69 |
| REAC | REAC:R-HSA-6807878 | COPI-mediated anterograde transport | COPI-mediated anterograde transport | 2 | 0.046467 | 69 |
Community 70
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:01232 | Nucleotide metabolism | Nucleotide metabolism | 2 | 0.014295 | 70 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0001651 | dense fibrillar component | "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561] | 1 | 0.02499 | 70 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-15869 | Metabolism of nucleotides | Metabolism of nucleotides | 2 | 0.036966 | 70 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0009201 | ribonucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 2 | 0.047469 | 70 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0034512 | box C/D sno(s)RNA binding | "Binding to a box C/D small nucleolar RNA." [GOC:mah] | 1 | 0.049724 | 70 |
Community 71
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M07259_1 | Factor: HSF1; motif: TCYAGAANNTTC; match class: 1 | Factor: HSF1; motif: TCYAGAANNTTC; match class: 1 | 3 | 0.029225 | 71 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0009000 | selenocysteine lyase activity | "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor." [EC:4.4.1.16] | 1 | 0.049724 | 71 |
Community 72
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0098798 | mitochondrial protein-containing complex | "A protein complex that is part of a mitochondrion." [GOC:dos] | 2 | 0.037375 | 72 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007006 | mitochondrial membrane organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 2 | 0.045101 | 72 |
Community 73
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471481 | Skin 2; sebaceous glands[≥Low] | Skin 2; sebaceous glands[≥Low] | 2 | 0.009374 | 73 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00750 | Vitamin B6 metabolism | Vitamin B6 metabolism | 1 | 0.011518 | 73 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004648 | O-phospho-L-serine:2-oxoglutarate aminotransferase activity | "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52] | 1 | 0.049891 | 73 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:816 | MRIP-RHOA complex | MRIP-RHOA complex | 1 | 0.049932 | 73 |
| CORUM | CORUM:817 | MRIP-MBS complex | MRIP-MBS complex | 1 | 0.049932 | 73 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034390 | Decreased CSF glycine concentration | Abnormally decreased levels of glycine in cerebrospinal fluid. | 1 | 0.049962 | 73 |
| HP | HP:0500226 | Abnormal CSF serine concentration | Any deviation from the normal concentration of serine in the cerebrospinal fluid. | 1 | 0.049962 | 73 |
| HP | HP:0500228 | Decreased CSF serine concentration | Abnormally decreased levels of serine in cerebrospinal fluid. | 1 | 0.049962 | 73 |
Community 75
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] | 2 | 0.007446 | 75 |
| GO:BP | GO:0006470 | protein dephosphorylation | "The process of removing one or more phosphoric residues from a protein." [GOC:hb] | 2 | 0.024261 | 75 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 2 | 0.047836 | 75 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004725 | protein tyrosine phosphatase activity | "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] | 2 | 0.013199 | 75 |
Community 76
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 2 | 0.030382 | 76 |
| GO:CC | GO:1990647 | C/EBP complex | "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, PMID:8657121] | 1 | 0.041231 | 76 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:746 | C/EBPalpha-HNF6 complex | C/EBPalpha-HNF6 complex | 1 | 0.049932 | 76 |
Community 77
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:2000975 | positive regulation of pro-B cell differentiation | "Any process that activates or increases the frequency, rate or extent of pro-B cell differentiation." [GOC:obol] | 1 | 0.049542 | 77 |
Community 79
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:299 | IRF3-CBP complex | IRF3-CBP complex | 1 | 0.049932 | 79 |
Community 80
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990660 | calprotectin complex | "A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways." [GOC:bhm, PMID:25417112] | 1 | 0.041231 | 80 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6826 | Calprotectin heterotetramer | Calprotectin heterotetramer | 1 | 0.049932 | 80 |
Community 81
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0071919 | G-quadruplex DNA formation | "A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature." [GOC:sre, PMID:20098422] | 1 | 0.049542 | 81 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0007889 | Iridescent posterior subcapsular cataract | A type of posterior subcapsular cataract characterized by an iridescent color. | 1 | 0.049962 | 81 |
Community 83
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0110051 | metabolite repair | "A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites." [GOC:ka, PMID:23334546, PMID:28373563] | 1 | 0.049542 | 83 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5506 | Disorders of NAD metabolism | Disorders of NAD metabolism | 1 | 0.049667 | 83 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047453 | ATP-dependent NAD(P)H-hydrate dehydratase activity | "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + H+ + NAD(P)H + phosphate." [EC:4.2.1.93, PMID:3061454] | 1 | 0.049891 | 83 |
Community 85
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0091012 | Cerebellum; molecular layer cells - nucleus[≥Medium] | Cerebellum; molecular layer cells - nucleus[≥Medium] | 2 | 0.015392 | 85 |
| HPA | HPA:0091011 | Cerebellum; molecular layer cells - nucleus[≥Low] | Cerebellum; molecular layer cells - nucleus[≥Low] | 2 | 0.018654 | 85 |
| HPA | HPA:0091072 | Cerebellum; white matter cells - cytoplasm/membrane[≥Medium] | Cerebellum; white matter cells - cytoplasm/membrane[≥Medium] | 2 | 0.026597 | 85 |
| HPA | HPA:0271111 | Kidney; bowman's capsule[≥Low] | Kidney; bowman's capsule[≥Low] | 2 | 0.039082 | 85 |
| HPA | HPA:0091071 | Cerebellum; white matter cells - cytoplasm/membrane[≥Low] | Cerebellum; white matter cells - cytoplasm/membrane[≥Low] | 2 | 0.044498 | 85 |
| HPA | HPA:0090971 | Cerebellum; granular cells - cytoplasm/membrane[≥Low] | Cerebellum; granular cells - cytoplasm/membrane[≥Low] | 2 | 0.047018 | 85 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7543 | KPNB1-SMN-SPN complex | KPNB1-SMN-SPN complex | 1 | 0.024966 | 85 |
| CORUM | CORUM:6142 | KPNA2-KPNB1 complex | KPNA2-KPNB1 complex | 1 | 0.049932 | 85 |
| CORUM | CORUM:6143 | KPNB1-RAN complex | KPNB1-RAN complex | 1 | 0.049932 | 85 |
Community 86
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 2 | 0.033208 | 86 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 2 | 0.033208 | 86 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 2 | 0.038214 | 86 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1248 | Apoptosome | Apoptosome | 1 | 0.049932 | 86 |
Community 87
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-887-3p | hsa-mir-887-3p | hsa-mir-887-3p | 1 | 0.027114 | 87 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3585 | Cytosine methylation | Cytosine methylation | 1 | 0.04995 | 87 |
Community 90
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06499 | Factor: znf383; motif: NGGTGGATAGGA | Factor: znf383; motif: NGGTGGATAGGA | 1 | 0.037328 | 90 |
Community 91
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M08618 | Factor: pitx1:FIGLA; motif: TAATCCNNNNCASCTG | Factor: pitx1:FIGLA; motif: TAATCCNNNNCASCTG | 2 | 0.01037 | 91 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-3681-3p | hsa-mir-3681-3p | hsa-mir-3681-3p | 2 | 0.022737 | 91 |
| MIRNA | MIRNA:hsa-mir-216a-3p | hsa-mir-216a-3p | hsa-mir-216a-3p | 2 | 0.023868 | 91 |
Community 92
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0410262 | Lower cranial nerve dysfunction | A functional abnormality affecting the lower cranial nerves, which include the paired 9th (glossopharyngeal), 10th (vagal), 11th (accessory) and 12th (hypoglossal) cranial nerves. | 1 | 0.049962 | 92 |
Community 93
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 2 | 0.007971 | 93 |
| WP | WP:WP4931 | Direct reversal repair | Direct reversal repair | 1 | 0.029803 | 93 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0033593 | BRCA2-MAGE-D1 complex | "A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth." [PMID:15930293] | 1 | 0.020616 | 93 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003908 | methylated-DNA-[protein]-cysteine S-methyltransferase activity | "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63] | 1 | 0.049891 | 93 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5657655 | MGMT-mediated DNA damage reversal | MGMT-mediated DNA damage reversal | 1 | 0.049932 | 93 |
Community 96
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0036116 | long-chain fatty-acyl-CoA catabolic process | "The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:pm] | 1 | 0.049542 | 96 |
| GO:BP | GO:1900533 | palmitic acid metabolic process | "The chemical reactions and pathways involving palmitic acid." [GOC:TermGenie] | 1 | 0.049542 | 96 |
| GO:BP | GO:1900535 | palmitic acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of palmitic acid." [GOC:TermGenie] | 1 | 0.049542 | 96 |
Community 97
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:2000720 | positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric | "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah] | 1 | 0.049542 | 97 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1851 | BUB1-BUB3 complex | BUB1-BUB3 complex | 1 | 0.049932 | 97 |
Community 98
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7236 | ARXN1-CIC complex | ARXN1-CIC complex | 1 | 0.049932 | 98 |
Community 99
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0160074 | non-canonical inflammasome complex | "An inflammasome complex containing CASP4, known as caspase-11 (Casp11) in mouse, which assembles upon cytosolic lipopolysaccharide-binding and directly activates Gasdermin-D (GSDMD)." [PMID:33187725] | 1 | 0.009989 | 99 |
Community 100
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006270 | DNA replication initiation | "The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641] | 2 | 0.001569 | 100 |
| GO:BP | GO:0006261 | DNA-templated DNA replication | "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] | 2 | 0.029973 | 100 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6140 | Cdt1-Geminin complex | Cdt1-Geminin complex | 1 | 0.049932 | 100 |
Community 101
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6212 | GM130-GRASP65 complex | GM130-GRASP65 complex | 1 | 0.049932 | 101 |
Community 102
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0002945 | cyclin K-CDK13 complex | "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] | 2 | 9.308233e-07 | 102 |
| GO:CC | GO:0008024 | cyclin/CDK positive transcription elongation factor complex | "A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit." [GOC:bhm, GOC:vw, PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473] | 2 | 2.606305e-05 | 102 |
| GO:CC | GO:0032806 | carboxy-terminal domain protein kinase complex | "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683] | 2 | 1.768564e-04 | 102 |
| GO:CC | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] | 2 | 3.025176e-04 | 102 |
| GO:CC | GO:0008023 | transcription elongation factor complex | "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl] | 2 | 1.186800e-03 | 102 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 2 | 2.120415e-03 | 102 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 2 | 8.927526e-03 | 102 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 2 | 1.082361e-02 | 102 |
| GO:CC | GO:0002944 | cyclin K-CDK12 complex | "A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] | 1 | 4.123082e-02 | 102 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 2 | 4.900785e-02 | 102 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008353 | RNA polymerase II CTD heptapeptide repeat kinase activity | "Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II." [EC:2.7.11.23, GOC:mah, PMID:28248323] | 2 | 0.000111 | 102 |
| GO:MF | GO:0140994 | RNA polymerase II CTD heptapeptide repeat modifying activity | "A catalytic activity that acts on the RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS). Reversible modifications cof the RNA polymerase II CTD repeats contribute to regulation of RNA polymerase activity." [GOC:pg] | 2 | 0.000739 | 102 |
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 2 | 0.006656 | 102 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 2 | 0.006656 | 102 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0032968 | positive regulation of transcription elongation by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] | 2 | 0.002887 | 102 |
| GO:BP | GO:0032786 | positive regulation of DNA-templated transcription, elongation | "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] | 2 | 0.003895 | 102 |
| GO:BP | GO:0034243 | regulation of transcription elongation by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] | 2 | 0.008815 | 102 |
| GO:BP | GO:0032784 | regulation of DNA-templated transcription elongation | "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] | 2 | 0.011431 | 102 |
| GO:BP | GO:0006368 | transcription elongation by RNA polymerase II | "The extension of an RNA molecule after transcription pausing and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] | 2 | 0.016266 | 102 |
| GO:BP | GO:0006354 | DNA-templated transcription elongation | "The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161] | 2 | 0.020997 | 102 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | TP53 Regulates Transcription of DNA Repair Genes | 2 | 0.008305 | 102 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1083 | P-TEFb.4 complex | P-TEFb.4 complex | 1 | 0.049932 | 102 |
Community 103
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M10119_1 | Factor: REX-1; motif: GGCMGCCATTTT; match class: 1 | Factor: REX-1; motif: GGCMGCCATTTT; match class: 1 | 2 | 0.037286 | 103 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0034967 | Set3 complex | "A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p." [GOC:ds, PMID:11711434] | 1 | 0.041231 | 103 |
| GO:CC | GO:0070210 | Rpd3L-Expanded complex | "A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720] | 1 | 0.041231 | 103 |
Community 104
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0211093 | Fallopian tube; non-ciliated cells[High] | Fallopian tube; non-ciliated cells[High] | 2 | 0.015029 | 104 |
Community 105
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-500a-3p | hsa-mir-500a-3p | hsa-mir-500a-3p | 2 | 0.005656 | 105 |
| MIRNA | MIRNA:hsa-mir-372-5p | hsa-mir-372-5p | hsa-mir-372-5p | 2 | 0.042890 | 105 |
| MIRNA | MIRNA:hsa-mir-371a-5p | hsa-mir-371a-5p | hsa-mir-371a-5p | 2 | 0.047942 | 105 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0036140 | [protein]-asparagine 3-dioxygenase activity | "Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2." [GOC:reh, PMID:12215170, RHEA:54260] | 1 | 0.049891 | 105 |
Community 106
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070603 | SWI/SNF superfamily-type complex | "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938] | 2 | 0.004156 | 106 |
| GO:CC | GO:1904949 | ATPase complex | "A protein complex which is capable of ATPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181] | 2 | 0.007566 | 106 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0461481 | Skin 1; sebaceous glands[≥Low] | Skin 1; sebaceous glands[≥Low] | 2 | 0.022011 | 106 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:2000779 | regulation of double-strand break repair | "Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF] | 2 | 0.023924 | 106 |
Community 107
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0050714 | positive regulation of protein secretion | "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] | 2 | 0.026332 | 107 |
| GO:BP | GO:2000331 | regulation of terminal button organization | "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah] | 1 | 0.049542 | 107 |
Community 108
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0044378 | non-sequence-specific DNA binding, bending | "The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:vw, PMID:20123079] | 1 | 0.049891 | 108 |
Community 111
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00400 | Phenylalanine, tyrosine and tryptophan biosynthesis | Phenylalanine, tyrosine and tryptophan biosynthesis | 1 | 0.011518 | 111 |
| KEGG | KEGG:00360 | Phenylalanine metabolism | Phenylalanine metabolism | 1 | 0.030715 | 111 |
| KEGG | KEGG:00220 | Arginine biosynthesis | Arginine biosynthesis | 1 | 0.042233 | 111 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M10659_1 | Factor: NKX6-3; motif: SYCATTAWN; match class: 1 | Factor: NKX6-3; motif: SYCATTAWN; match class: 1 | 2 | 0.011775 | 111 |
| TF | TF:M10658_1 | Factor: NKX6B; motif: NTMATTAA; match class: 1 | Factor: NKX6B; motif: NTMATTAA; match class: 1 | 2 | 0.017688 | 111 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0015908 | fatty acid transport | "The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [GOC:ai] | 2 | 0.017392 | 111 |
| GO:BP | GO:0015718 | monocarboxylic acid transport | "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] | 2 | 0.039240 | 111 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4315 | Malate aspartate shuttle | Malate aspartate shuttle | 1 | 0.039736 | 111 |
| WP | WP:WP5507 | Mitochondrial carrier deficiency associated with shuttle disturbances | Mitochondrial carrier deficiency associated with shuttle disturbances | 1 | 0.049667 | 111 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-196a-5p | hsa-mir-196a-5p | hsa-mir-196a-5p | 2 | 0.044752 | 111 |
Community 112
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3596 | miR 517 relationship with ARCN1 and USP1 | miR 517 relationship with ARCN1 and USP1 | 1 | 0.031218 | 112 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0031673 | H zone | "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [GOC:mtg_muscle, ISBN:0321204131] | 1 | 0.041231 | 112 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0012822 | Bilateral vocal cord paresis | Decreased strength of the vocal fold on both sides. | 1 | 0.049962 | 112 |
Community 113
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:404 | Isocitrate dehydrogenase [NADP], cytoplasmic | Isocitrate dehydrogenase [NADP], cytoplasmic | 1 | 0.024966 | 113 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-2978092 | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | 1 | 0.049932 | 113 |
Community 115
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1903096 | protein localization to meiotic spindle midzone | "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle midzone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:12707312] | 1 | 0.049542 | 115 |
| GO:BP | GO:1905359 | protein localization to meiotic spindle | "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle." [GO_REF:0000087, GOC:TermGenie, PMID:26696398] | 1 | 0.049542 | 115 |
Community 117
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:mir-322-5p | mir-322-5p | mir-322-5p | 1 | 0.018269 | 117 |
Community 119
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0036284 | tubulobulbar complex | "Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes." [GOC:sl, PMID:22510523] | 1 | 0.041231 | 119 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011896 | Subconjunctival hemorrhage | Bleeding beneath the mucous membrane that lines the inner surface of the eyelid. | 1 | 0.049962 | 119 |
Community 120
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1902104 | positive regulation of metaphase/anaphase transition of meiotic cell cycle | "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] | 1 | 0.049542 | 120 |
| GO:BP | GO:1905134 | positive regulation of meiotic chromosome separation | "Any process that activates or increases the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645] | 1 | 0.049542 | 120 |
| GO:BP | GO:1905186 | regulation of metaphase/anaphase transition of meiosis I | "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] | 1 | 0.049542 | 120 |
| GO:BP | GO:1905188 | positive regulation of metaphase/anaphase transition of meiosis I | "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] | 1 | 0.049542 | 120 |
Community 123
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0030379 | neurotensin receptor activity, non-G protein-coupled | "Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins." [GOC:mah, GOC:signaling, PMID:9756851] | 1 | 0.049891 | 123 |
| GO:MF | GO:0048257 | 3'-flap endonuclease activity | "Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid, PMID:10635319] | 1 | 0.049891 | 123 |
Community 124
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-5088-3p | hsa-mir-5088-3p | hsa-mir-5088-3p | 2 | 0.013967 | 124 |
| MIRNA | MIRNA:hsa-mir-145-5p | hsa-mir-145-5p | hsa-mir-145-5p | 2 | 0.030708 | 124 |
Community 125
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0019520 | aldonic acid metabolic process | "The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732] | 1 | 0.049542 | 125 |
| GO:BP | GO:0019521 | D-gluconate metabolic process | "The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732] | 1 | 0.049542 | 125 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity | "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44] | 1 | 0.049891 | 125 |
Community 126
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04215 | Apoptosis - multiple species | Apoptosis - multiple species | 2 | 0.000365 | 126 |
| KEGG | KEGG:01524 | Platinum drug resistance | Platinum drug resistance | 2 | 0.001879 | 126 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 2 | 0.002687 | 126 |
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 2 | 0.006650 | 126 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 2 | 0.009587 | 126 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3646 | Hepatitis C and hepatocellular carcinoma | Hepatitis C and hepatocellular carcinoma | 2 | 0.001748 | 126 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 2 | 0.002984 | 126 |
| WP | WP:WP254 | Apoptosis | Apoptosis | 2 | 0.004247 | 126 |
| WP | WP:WP1772 | Apoptosis modulation and signaling | Apoptosis modulation and signaling | 2 | 0.004547 | 126 |
| WP | WP:WP4659 | Gastrin signaling | Gastrin signaling | 2 | 0.007313 | 126 |
| WP | WP:WP4666 | Hepatitis B infection | Hepatitis B infection | 2 | 0.013029 | 126 |
| WP | WP:WP5115 | Network map of SARS CoV 2 signaling | Network map of SARS CoV 2 signaling | 2 | 0.036193 | 126 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004197 | cysteine-type endopeptidase activity | "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE] | 2 | 0.018793 | 126 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990713 | survivin complex | "A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC)." [GOC:bhm, PMID:10949038] | 1 | 0.020616 | 126 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2580 | Survivin homodimer complex | Survivin homodimer complex | 1 | 0.024966 | 126 |
| CORUM | CORUM:2581 | RasGAP-AURKA-survivin complex | RasGAP-AURKA-survivin complex | 1 | 0.049932 | 126 |
| CORUM | CORUM:6756 | RasGAP-AURKB-survivin complex | RasGAP-AURKB-survivin complex | 1 | 0.049932 | 126 |
| CORUM | CORUM:1117 | CRM1-Survivin mitotic complex | CRM1-Survivin mitotic complex | 1 | 0.049932 | 126 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007605 | sensory perception of sound | "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] | 2 | 0.033450 | 126 |
| GO:BP | GO:0050954 | sensory perception of mechanical stimulus | "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] | 2 | 0.045029 | 126 |
Community 127
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-105-5p | hsa-mir-105-5p | hsa-mir-105-5p | 2 | 0.004800 | 127 |
| MIRNA | MIRNA:hsa-mir-18a-5p | hsa-mir-18a-5p | hsa-mir-18a-5p | 2 | 0.034177 | 127 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:518 | AKAP250-PKA-PDE4D complex | AKAP250-PKA-PDE4D complex | 1 | 0.049932 | 127 |
Community 128
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1306 | PIN1-AUF1 complex | PIN1-AUF1 complex | 1 | 0.049932 | 128 |
Community 129
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03430 | Mismatch repair | Mismatch repair | 1 | 0.044153 | 129 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0051908 | double-stranded DNA 5'-3' DNA exonuclease activity | "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule." [GOC:ai] | 1 | 0.049891 | 129 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:424 | EXO1-MLH1-PCNA complex | EXO1-MLH1-PCNA complex | 1 | 0.049932 | 129 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0040287 | Axial muscle atrophy | Axial muscle atrophy | 1 | 0.049962 | 129 |
| HP | HP:0100298 | Motheaten muscle fibers | Motheaten muscle fibers | 1 | 0.049962 | 129 |
Community 130
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1028 | HNF4A-SUB1 complex | HNF4A-SUB1 complex | 1 | 0.049932 | 130 |
Community 131
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0030332 | cyclin binding | "Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] | 2 | 0.001383 | 131 |
Community 133
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-194-3p | hsa-mir-194-3p | hsa-mir-194-3p | 2 | 0.005113 | 133 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0086098 | angiotensin-activated signaling pathway involved in heart process | "An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402] | 1 | 0.049542 | 133 |
Community 134
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1982 | CACY homodimer complex | CACY homodimer complex | 1 | 0.024966 | 134 |
Community 135
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0034443 | negative regulation of lipoprotein oxidation | "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah] | 1 | 0.049542 | 135 |
| GO:BP | GO:0060588 | negative regulation of lipoprotein lipid oxidation | "Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:dph, GOC:tb] | 1 | 0.049542 | 135 |
Community 138
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008832 | dGTPase activity | "Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate." [RHEA:15193] | 1 | 0.049891 | 138 |
| GO:MF | GO:0016793 | triphosphoric monoester hydrolase activity | "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [EC:3.1.5.-] | 1 | 0.049891 | 138 |
| GO:MF | GO:0032560 | guanyl deoxyribonucleotide binding | "Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] | 1 | 0.049891 | 138 |
| GO:MF | GO:0032567 | dGTP binding | "Binding to dGTP, deoxyguanosine triphosphate." [GOC:mah] | 1 | 0.049891 | 138 |
| GO:MF | GO:0106375 | deoxynucleoside triphosphate hydrolase activity | "Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate." [RHEA:46148] | 1 | 0.049891 | 138 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:6000263 | Papillary dermal edema | Swelling due to fluid acculuation of the papillary dermis. | 1 | 0.049962 | 138 |
Community 140
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP179 | Cell cycle | Cell cycle | 2 | 0.008107 | 140 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 2 | 0.009003 | 140 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 2 | 0.01582 | 140 |
Community 141
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0062073 | histone mRNA stem-loop binding complex | "A protein-containing complex composed of a stem-loop binding protein (in most species SLBP) and its interacting partner (SLIP1 or MIF4GD in most species) that binds to the histone mRNA (hmRNA) 3-prime-stem-loop structure. Facilitates hmRNA translation initiation and may also be involved in its processing and nuclear export." [GOC:bhm, PMID:18025107, PMID:23286197] | 1 | 0.041231 | 141 |
Community 142
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0411242 | Retina; inner plexiform layer[≥Medium] | Retina; inner plexiform layer[≥Medium] | 1 | 0.047315 | 142 |
| HPA | HPA:0411253 | Retina; nerve fiber layer[High] | Retina; nerve fiber layer[High] | 1 | 0.047315 | 142 |
Community 143
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-29a-3p | hsa-mir-29a-3p | hsa-mir-29a-3p | 2 | 0.028666 | 143 |
Community 144
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006535 | cysteine biosynthetic process from serine | "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators] | 1 | 0.049542 | 144 |
| GO:BP | GO:0019255 | glucose 1-phosphate metabolic process | "The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1." [GOC:ai] | 1 | 0.049542 | 144 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003983 | UTP:glucose-1-phosphate uridylyltransferase activity | "Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [EC:2.7.7.9, RHEA:19889] | 1 | 0.049891 | 144 |
| GO:MF | GO:0004122 | cystathionine beta-synthase activity | "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22] | 1 | 0.049891 | 144 |
| GO:MF | GO:0051748 | UTP-monosaccharide-1-phosphate uridylyltransferase activity | "Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide." [EC:2.7.7.64, PMID:15326166] | 1 | 0.049891 | 144 |
Community 146
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1903503 | ATPase inhibitor complex | "A protein complex which is capable of ATPase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16170325] | 1 | 0.029966 | 146 |
| GO:CC | GO:1990501 | exon-exon junction subcomplex mago-y14 | "Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA." [GOC:bhm, PMID:12730685] | 1 | 0.029966 | 146 |
Community 147
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00670 | One carbon pool by folate | One carbon pool by folate | 1 | 0.038394 | 147 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003937 | IMP cyclohydrolase activity | "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10] | 1 | 0.049891 | 147 |
| GO:MF | GO:0004643 | phosphoribosylaminoimidazolecarboxamide formyltransferase activity | "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3] | 1 | 0.049891 | 147 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034565 | Elevated urinary 5-amino-4-imidazolecarboxamide-riboside level | Increased amount of 5-amino-4-imidazolecarboxamide(AICA)-riboside in the urine. AICA-riboside is the dephosphorylated counterpart of AICAR, an intermediate of de novo purine biosynthesis. | 1 | 0.049962 | 147 |
| HP | HP:6000752 | Elevated erythrocyte AICA-ribotide concentration | Concentration of 5-amino-4-imidazolecarboxamide (AICA-riboside) in red blood cells is above the upper limit of normal. | 1 | 0.049962 | 147 |
Community 148
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0045259 | proton-transporting ATP synthase complex | "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [ISBN:0198547684, ISBN:0716743663] | 2 | 0.000127 | 148 |
| GO:CC | GO:0016469 | proton-transporting two-sector ATPase complex | "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483] | 2 | 0.001095 | 148 |
| GO:CC | GO:0098803 | respiratory chain complex | "Any protein complex that is part of a respiratory chain." [GOC:dos] | 2 | 0.004795 | 148 |
| GO:CC | GO:0034703 | cation channel complex | "An ion channel complex through which cations pass." [GOC:mah] | 2 | 0.023457 | 148 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism | "Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722] | 2 | 0.000377 | 148 |
| GO:MF | GO:0015252 | proton channel activity | "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] | 2 | 0.000932 | 148 |
| GO:MF | GO:0016874 | ligase activity | "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-] | 2 | 0.037951 | 148 |
| GO:MF | GO:0015078 | proton transmembrane transporter activity | "Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai] | 2 | 0.042400 | 148 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-163210 | Formation of ATP by chemiosmotic coupling | Formation of ATP by chemiosmotic coupling | 2 | 0.000694 | 148 |
| REAC | REAC:R-HSA-8949613 | Cristae formation | Cristae formation | 2 | 0.002110 | 148 |
| REAC | REAC:R-HSA-1592230 | Mitochondrial biogenesis | Mitochondrial biogenesis | 2 | 0.018583 | 148 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP623 | Oxidative phosphorylation | Oxidative phosphorylation | 2 | 0.002010 | 148 |
| WP | WP:WP111 | Electron transport chain OXPHOS system in mitochondria | Electron transport chain OXPHOS system in mitochondria | 2 | 0.006081 | 148 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis | "The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force)." [GOC:vw] | 2 | 0.005210 | 148 |
| GO:BP | GO:0015986 | proton motive force-driven ATP synthesis | "The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force)." [GOC:vw] | 2 | 0.007076 | 148 |
| GO:BP | GO:0006754 | ATP biosynthetic process | "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732] | 2 | 0.012137 | 148 |
| GO:BP | GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 2 | 0.014911 | 148 |
| GO:BP | GO:0009145 | purine nucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 2 | 0.015177 | 148 |
| GO:BP | GO:0009201 | ribonucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 2 | 0.016544 | 148 |
| GO:BP | GO:0009142 | nucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 2 | 0.018853 | 148 |
| GO:BP | GO:0006119 | oxidative phosphorylation | "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309] | 2 | 0.024942 | 148 |
| GO:BP | GO:0009152 | purine ribonucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 2 | 0.030350 | 148 |
| GO:BP | GO:0009260 | ribonucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 2 | 0.036287 | 148 |
| GO:BP | GO:0046390 | ribose phosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 2 | 0.039240 | 148 |
| GO:BP | GO:1902600 | proton transmembrane transport | "The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] | 2 | 0.042308 | 148 |
| GO:BP | GO:0006164 | purine nucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 2 | 0.043658 | 148 |
| GO:BP | GO:0009060 | aerobic respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] | 2 | 0.046422 | 148 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00190 | Oxidative phosphorylation | Oxidative phosphorylation | 2 | 0.006551 | 148 |
| KEGG | KEGG:04714 | Thermogenesis | Thermogenesis | 2 | 0.019700 | 148 |
Community 149
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708] | 2 | 0.005054 | 149 |
| GO:BP | GO:0032848 | negative regulation of cellular pH reduction | "Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] | 1 | 0.049542 | 149 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | Adrenergic signaling in cardiomyocytes | 2 | 0.008549 | 149 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP1438 | Influenza A virus infection | Influenza A virus infection | 1 | 0.009936 | 149 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:mir-153 | mir-153 | mir-153 | 1 | 0.018269 | 149 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097138 | BAD-BCL-2 complex | "A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] | 1 | 0.041231 | 149 |
| GO:CC | GO:0031965 | nuclear membrane | "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] | 2 | 0.047807 | 149 |
Community 150
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0004817 | Drug-sensitive hemolytic anemia | A form of hemolytic anemia that is triggered by ingestion of certain drugs. | 1 | 0.049962 | 150 |
| HP | HP:0011905 | Reduced hemoglobin A | Hemoglobin A (HbA) contains two globin alpha chains and two globin beta chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decreased in the proportion of HbA below this limit, and can be seen in various forms of thalassemia. | 1 | 0.049962 | 150 |
| HP | HP:0011906 | Reduced beta/alpha synthesis ratio | A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia. | 1 | 0.049962 | 150 |
| HP | HP:0020058 | Abnormal red blood cell count | Any deviation from the normal number of red blood cells per volume in the circulation. | 1 | 0.049962 | 150 |
| HP | HP:0020059 | Increased red blood cell count | An abnormal elevation above the normal number of red blood cells per volume in the circulation. | 1 | 0.049962 | 150 |
| HP | HP:0030058 | Sickled erythrocytes | An irreversible distortion of the morphology of an erythrocyte such that the cells are elongated and curved, resembling the blade of a sickle (the hand-held agricultural tool traditionally used to harvest grains). | 1 | 0.049962 | 150 |
| HP | HP:0031090 | Finger dactylitis | Fingers appear swollen and plump owing to inflammation of the complete finger. | 1 | 0.049962 | 150 |
| HP | HP:0200023 | Priapism | A painful and harmful medical condition in which the erect penis doesn't return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours. | 1 | 0.049962 | 150 |
Community 151
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 2 | 0.007098 | 151 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 2 | 0.015671 | 151 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 2 | 0.048406 | 151 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 2 | 0.049918 | 151 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6208 | PNP homotrimer complex | PNP homotrimer complex | 1 | 0.024966 | 151 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 2 | 0.037071 | 151 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006738 | nicotinamide riboside catabolic process | "The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732] | 1 | 0.049542 | 151 |
| GO:BP | GO:0046495 | nicotinamide riboside metabolic process | "The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732] | 1 | 0.049542 | 151 |
| GO:BP | GO:0070637 | pyridine nucleoside metabolic process | "The chemical reactions and pathways involving any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [GOC:mah] | 1 | 0.049542 | 151 |
| GO:BP | GO:0070638 | pyridine nucleoside catabolic process | "The chemical reactions and pathways resulting in the breakdown of any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [GOC:mah] | 1 | 0.049542 | 151 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9735786 | Nucleotide catabolism defects | Nucleotide catabolism defects | 1 | 0.049932 | 151 |
| REAC | REAC:R-HSA-9735763 | Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine | Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine | 1 | 0.049932 | 151 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0032166 | Unusual gastrointestinal infection | Unusual gastrointestinal infection | 1 | 0.049962 | 151 |
| HP | HP:0033339 | Increased circulating inosine concentration | An increased concentration of inosine in the blood circulation. | 1 | 0.049962 | 151 |
| HP | HP:0033340 | Increased circulating guanosine concentration | Increased concentration of guanosine in the blood circulation. | 1 | 0.049962 | 151 |
| HP | HP:0040421 | Abnormal urinary inosine level | The amount of inosine in the urine, normalized for urine concentration, is outside the limits of normal. | 1 | 0.049962 | 151 |
| HP | HP:0040422 | Elevated urinary inosine level | The amount of inosine in the urine, normalized for urine concentration, is above the upper limit of normal. | 1 | 0.049962 | 151 |
| HP | HP:0040423 | Abnormal urinary guanosine level | The amount of guanosine in the urine, normalized for urine concentration, is outside the limits of normal. | 1 | 0.049962 | 151 |
| HP | HP:0040424 | Elevated urinary guanosine level | The amount of guanosine in the urine, normalized for urine concentration, is above the upper limit of normal. | 1 | 0.049962 | 151 |
Community 152
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-111995 | phospho-PLA2 pathway | phospho-PLA2 pathway | 1 | 0.024966 | 152 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06281 | Factor: ZNF805; motif: NGKWTCATCAGM | Factor: ZNF805; motif: NGKWTCATCAGM | 1 | 0.037328 | 152 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00592 | alpha-Linolenic acid metabolism | alpha-Linolenic acid metabolism | 1 | 0.049912 | 152 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0030389 | Abnormal circulating thromboxane concentration | Any deviation from the normal concentration in the blood circulation of a thromboxane. Thromboxanes are derived from prostaglandin precursors in platelets, and stimulate aggregation of platelets and constriction of blood vessels. | 1 | 0.049962 | 152 |
| HP | HP:0032244 | Decreased serum thromboxane B2 | A reduction in the concentration of thromboxane B2 in the blood circulation. | 1 | 0.049962 | 152 |
| HP | HP:0032575 | Decreased circulating 12-HETE | A reduction in the concentration of 12-HETE in the blood circulation, a metabolite of arachidonic acid. | 1 | 0.049962 | 152 |
Community 153
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6080 | hsa-mir-6080 | hsa-mir-6080 | 1 | 0.04971 | 153 |
Community 155
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6786-5p | hsa-mir-6786-5p | hsa-mir-6786-5p | 1 | 0.031633 | 155 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0009555 | Hypoplasia of the pharynx | Underdevelopment of the pharynx. | 1 | 0.049962 | 155 |
| HP | HP:6000612 | Squamosal suture synostosis | Premature closure of the squamosal suture, which is one of the lateral minor skull sutures, separating the parietal and squamous temporal bones. | 1 | 0.049962 | 155 |
Community 156
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004349 | glutamate 5-kinase activity | "Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+." [EC:2.7.2.11, RHEA:14877] | 1 | 0.024946 | 156 |
| GO:MF | GO:0004350 | glutamate-5-semialdehyde dehydrogenase activity | "Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH." [EC:1.2.1.41, RHEA:19541] | 1 | 0.024946 | 156 |
| GO:MF | GO:0019202 | amino acid kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl] | 1 | 0.049891 | 156 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006592 | ornithine biosynthetic process | "The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] | 1 | 0.049542 | 156 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0500139 | Hypoprolinemia | A decreased amount of proline in the blood. | 1 | 0.049962 | 156 |
Community 157
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6791462 | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | 1 | 0.012483 | 157 |
| REAC | REAC:R-HSA-6791055 | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | 1 | 0.012483 | 157 |
| REAC | REAC:R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1 | 0.024966 | 157 |
| REAC | REAC:R-HSA-6791465 | Pentose phosphate pathway disease | Pentose phosphate pathway disease | 1 | 0.024966 | 157 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004801 | transaldolase activity | "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [PMID:7592346, RHEA:17053] | 1 | 0.024946 | 157 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP134 | Pentose phosphate metabolism | Pentose phosphate metabolism | 1 | 0.043706 | 157 |
| WP | WP:WP5043 | Pentose phosphate pathway in senescent cells | Pentose phosphate pathway in senescent cells | 1 | 0.049950 | 157 |
Community 158
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M07398_1 | Factor: Brn-3b; motif: RCTCATTAAN; match class: 1 | Factor: Brn-3b; motif: RCTCATTAAN; match class: 1 | 1 | 0.037328 | 158 |
Community 159
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00524 | Neomycin, kanamycin and gentamicin biosynthesis | Neomycin, kanamycin and gentamicin biosynthesis | 1 | 0.009598 | 159 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5619056 | Defective HK1 causes hexokinase deficiency (HK deficiency) | Defective HK1 causes hexokinase deficiency (HK deficiency) | 1 | 0.012483 | 159 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047931 | glucosamine kinase activity | "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H+." [RHEA:10948] | 1 | 0.024946 | 159 |
| GO:MF | GO:0019158 | mannokinase activity | "Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate." [EC:2.7.1.7] | 1 | 0.049891 | 159 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5211 | Glucose metabolism in triple negative breast cancer cells | Glucose metabolism in triple negative breast cancer cells | 1 | 0.04995 | 159 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:6000559 | Reduced erythrocyte hexokinase activity | Activity or concentration of hexokinase (EC 2.7.1.1) in red blood cells below the lower limit of normal. Arginase catalyzes the last step of the urea cycle. | 1 | 0.049962 | 159 |
Community 160
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7224 | HCF1-THAP11 complex | HCF1-THAP11 complex | 1 | 0.049932 | 160 |
| CORUM | CORUM:7260 | HCFC1-THAP11 subcomplex | HCFC1-THAP11 subcomplex | 1 | 0.049932 | 160 |
Community 161
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03450 | Non-homologous end-joining | Non-homologous end-joining | 1 | 0.024956 | 161 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7282 | FEN1-WRN complex | FEN1-WRN complex | 1 | 0.049932 | 161 |
Community 164
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2308 | AP3D1-AP3S1 complex | AP3D1-AP3S1 complex | 1 | 0.049932 | 164 |
Community 165
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06267 | Factor: ZNF805; motif: NGGTAGGKCGTT | Factor: ZNF805; motif: NGGTAGGKCGTT | 1 | 0.049771 | 165 |
Community 166
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6869-3p | hsa-mir-6869-3p | hsa-mir-6869-3p | 1 | 0.020336 | 166 |
| MIRNA | MIRNA:hsa-mir-548ad-3p | hsa-mir-548ad-3p | hsa-mir-548ad-3p | 1 | 0.040671 | 166 |
| MIRNA | MIRNA:hsa-mir-6503-3p | hsa-mir-6503-3p | hsa-mir-6503-3p | 1 | 0.042931 | 166 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0072356 | chromosome passenger complex localization to kinetochore | "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis." [GOC:mah] | 1 | 0.049542 | 166 |
Community 167
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:1901707 | leptomycin B binding | "Binding to leptomycin B." [GOC:TermGenie] | 1 | 0.024946 | 167 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0072750 | cellular response to leptomycin B | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:mah] | 1 | 0.049542 | 167 |
| GO:BP | GO:1901344 | response to leptomycin B | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:TermGenie] | 1 | 0.049542 | 167 |
Community 171
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03450 | Non-homologous end-joining | Non-homologous end-joining | 1 | 0.024956 | 171 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12446_1 | Factor: BHLHE22; motif: NNCAGCTGNN; match class: 1 | Factor: BHLHE22; motif: NNCAGCTGNN; match class: 1 | 1 | 0.049771 | 171 |
Community 175
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0099160 | postsynaptic intermediate filament cytoskeleton | "The intermediate filament cytoskeleton that is part of a postsynapse." [GOC:dos, PMID:25869803] | 1 | 0.039955 | 175 |
| GO:CC | GO:0097418 | neurofibrillary tangle | "Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star." [NIF_Subcellular:nlx_subcell_20090201, NIF_Subcellular:nlx_subcell_20090202, NIF_Subcellular:sao2409833926] | 1 | 0.049943 | 175 |
Community 176
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0071001 | U4/U6 snRNP | "A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897, PMID:14685174] | 1 | 0.029966 | 176 |
| GO:CC | GO:0061574 | ASAP complex | "A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1." [GOC:dph, PMID:12665594, PMID:16314458, PMID:22388736] | 1 | 0.039955 | 176 |
Community 185
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-8985801 | Regulation of cortical dendrite branching | Regulation of cortical dendrite branching | 1 | 0.049932 | 185 |
| REAC | REAC:R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | SLIT2:ROBO1 increases RHOA activity | 1 | 0.049932 | 185 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011679 | Tetralogy of Fallot with pulmonary stenosis | The commonest form of tetralogy of Fallot characterized by pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy, without pulmonary atresia, absent pulmonary valve, atrioventricular canal defect or absent subarterial conus. | 1 | 0.049962 | 185 |
| HP | HP:0034976 | Absent pituitary stalk | A developmental defect characterized by failure to develop of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland. | 1 | 0.049962 | 185 |
| HP | HP:0034977 | Abnormal pituitary stalk morphology | A structural anomaly of the pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland. | 1 | 0.049962 | 185 |
| HP | HP:0034978 | Interrupted pituitary stalk | A developmental defect characterized by a discontinuity of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland. | 1 | 0.049962 | 185 |
Community 190
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0032034 | myosin II head/neck binding | "Binding to the head/neck region of a myosin II heavy chain." [GOC:mah] | 1 | 0.024946 | 190 |
| GO:MF | GO:0032028 | myosin head/neck binding | "Binding to the head/neck region of a myosin heavy chain." [GOC:mah] | 1 | 0.049891 | 190 |
Community 194
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005854 | nascent polypeptide-associated complex | "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149] | 1 | 0.039955 | 194 |
Community 197
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0019118 | phenanthrene-epoxide hydrolase activity | "Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0535, UM-BBD_reactionID:r0536] | 1 | 0.024946 | 197 |
| GO:MF | GO:0019119 | phenanthrene-9,10-epoxide hydrolase activity | "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0496, UM-BBD_reactionID:r0560] | 1 | 0.024946 | 197 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP699 | Aflatoxin B1 metabolism | Aflatoxin B1 metabolism | 1 | 0.043706 | 197 |
Community 198
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-5707 | hsa-mir-5707 | hsa-mir-5707 | 1 | 0.036152 | 198 |
Community 199
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0050346 | trans-L-3-hydroxyproline dehydratase activity | "Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H2O + H+." [EC:4.2.1.77, RHEA:10320] | 1 | 0.024946 | 199 |
Community 202
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05523_1 | Factor: ZBTB46; motif: NGGGGGATAGN; match class: 1 | Factor: ZBTB46; motif: NGGGGGATAGN; match class: 1 | 1 | 0.012443 | 202 |
Community 204
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004831 | tyrosine-tRNA ligase activity | "Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+." [EC:6.1.1.1, RHEA:10220] | 1 | 0.049891 | 204 |
Community 206
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0008247 | 1-alkyl-2-acetylglycerophosphocholine esterase complex | "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF)." [GOC:jl, PMID:10542206] | 1 | 0.029966 | 206 |
Community 207
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12081 | Factor: ZNF76; motif: NYTWCCCAYAATGCAYYRCNN | Factor: ZNF76; motif: NYTWCCCAYAATGCAYYRCNN | 1 | 0.049771 | 207 |
Community 208
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990917 | ooplasm | "The cytoplasm of an ovum." [PMID:19022436] | 1 | 0.019977 | 208 |
Community 209
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0020033 | Adrenal gland; cells in zona glomerulosa[High] | Adrenal gland; cells in zona glomerulosa[High] | 1 | 0.049944 | 209 |
Community 210
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0086060 | voltage-gated sodium channel activity involved in AV node cell action potential | "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 1 | 0.024946 | 210 |
| GO:MF | GO:0086061 | voltage-gated sodium channel activity involved in bundle of His cell action potential | "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 1 | 0.024946 | 210 |
| GO:MF | GO:0086062 | voltage-gated sodium channel activity involved in Purkinje myocyte action potential | "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 1 | 0.024946 | 210 |
| GO:MF | GO:0086063 | voltage-gated sodium channel activity involved in SA node cell action potential | "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 1 | 0.024946 | 210 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6096 | alphaB-crystallin-Nav1.5 complex | alphaB-crystallin-Nav1.5 complex | 1 | 0.049932 | 210 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0005170 | Complete heart block with broad QRS complexes | A type of third degree heart block in which the escape rhythm arises at a relatively low part of the conduction system (below the atrioventricular node), which produces a wide QRS complex. | 1 | 0.049962 | 210 |
| HP | HP:0005172 | Left posterior fascicular block | Conduction block in the posterior division of the left bundle branch of the bundle of His. | 1 | 0.049962 | 210 |
| HP | HP:0011841 | Ventricular flutter | A potentially lethal cardiac arrhythmia characterized by an extremely rapid, hemodynamically unstable ventricular tachycardia (150-300 beats/min) with a large oscillating sine-wave appearance. | 1 | 0.049962 | 210 |
Community 212
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045344 | negative regulation of MHC class I biosynthetic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] | 1 | 0.049542 | 212 |
Community 217
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06763 | Factor: ZNF225; motif: NGGGWAAAMCGN | Factor: ZNF225; motif: NGGGWAAAMCGN | 1 | 0.049771 | 217 |
Community 219
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0098892 | extrinsic component of postsynaptic specialization membrane | "The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] | 1 | 0.049943 | 219 |
| GO:CC | GO:0099147 | extrinsic component of postsynaptic density membrane | "The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] | 1 | 0.049943 | 219 |
Community 221
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12336 | Factor: BCL-6B; motif: NCGTAATCTAGGAATN | Factor: BCL-6B; motif: NCGTAATCTAGGAATN | 1 | 0.012443 | 221 |
Community 222
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0003359 | noradrenergic neuron fate commitment | "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph] | 1 | 0.049542 | 222 |
| GO:BP | GO:0007400 | neuroblast fate determination | "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators] | 1 | 0.049542 | 222 |
| GO:BP | GO:0014017 | neuroblast fate commitment | "The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585] | 1 | 0.049542 | 222 |
| GO:BP | GO:0060165 | regulation of timing of subpallium neuron differentiation | "The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon." [GOC:dph] | 1 | 0.049542 | 222 |
| GO:BP | GO:0061100 | lung neuroendocrine cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium." [GOC:dph, PMID:9126746] | 1 | 0.049542 | 222 |
| GO:BP | GO:0061103 | carotid body glomus cell differentiation | "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia." [GOC:dph, PMID:6243386] | 1 | 0.049542 | 222 |
| GO:BP | GO:0071259 | cellular response to magnetism | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:mah] | 1 | 0.049542 | 222 |
Community 228
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M08258_1 | Factor: ER71:FOXI1; motif: TGTTKACGGAAGTN; match class: 1 | Factor: ER71:FOXI1; motif: TGTTKACGGAAGTN; match class: 1 | 1 | 0.049771 | 228 |
Community 231
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004796 | thromboxane-A synthase activity | "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17137] | 1 | 0.049891 | 231 |
Community 232
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | Signaling by plasma membrane FGFR1 fusions | 1 | 0.037449 | 232 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0033205 | Biceps hyperreflexia | Increased intensity of the biceps reflex. | 1 | 0.049962 | 232 |
Community 233
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1905202 | methylcrotonoyl-CoA carboxylase complex | "A protein complex capable of methylcrotonoyl-CoA carboxylase activity. In mammals, it is a mitochondrial complex comprising a dodecamer of 6 alpha and 6 beta subunits: MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation; MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:bf, GOC:hjd, GOC:PARL, PMID:15868465, PMID:17360195, PMID:22158123, PMID:22869039] | 1 | 0.019977 | 233 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004485 | methylcrotonoyl-CoA carboxylase activity | "Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate." [EC:6.4.1.4, RHEA:13589] | 1 | 0.049891 | 233 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7190 | 3-methylcrotonyl-CoA carboxylase | 3-methylcrotonyl-CoA carboxylase | 1 | 0.049932 | 233 |
Community 235
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03265 | Virion - Ebolavirus and Lyssavirus | Virion - Ebolavirus and Lyssavirus | 1 | 0.011518 | 235 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5408 | Neurotrophin-3-p75 complex | Neurotrophin-3-p75 complex | 1 | 0.024966 | 235 |
| CORUM | CORUM:1794 | SORT1-NGFR complex | SORT1-NGFR complex | 1 | 0.049932 | 235 |
| CORUM | CORUM:5424 | NGF-p75 complex | NGF-p75 complex | 1 | 0.049932 | 235 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-205017 | NFG and proNGF binds to p75NTR | NFG and proNGF binds to p75NTR | 1 | 0.024966 | 235 |
| REAC | REAC:R-HSA-193681 | Ceramide signalling | Ceramide signalling | 1 | 0.037449 | 235 |
| REAC | REAC:R-HSA-209563 | Axonal growth stimulation | Axonal growth stimulation | 1 | 0.049932 | 235 |
Community 237
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0031416 | NatB complex | "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471] | 1 | 0.019977 | 237 |
biogrid+hippie (Louvain)
Community 0
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 146 | 1.356907e-75 | 0 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 146 | 9.570959e-75 | 0 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 146 | 1.020943e-74 | 0 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 146 | 1.020943e-74 | 0 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 179 | 3.775306e-67 | 0 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 153 | 1.559072e-55 | 0 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 161 | 2.033232e-47 | 0 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 255 | 9.987572e-46 | 0 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 168 | 5.026524e-37 | 0 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 99 | 3.689051e-25 | 0 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 99 | 4.442036e-25 | 0 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 257 | 5.520056e-24 | 0 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 131 | 4.007855e-20 | 0 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 260 | 9.018923e-20 | 0 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 265 | 1.890063e-19 | 0 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 21 | 1.252843e-16 | 0 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 21 | 1.252843e-16 | 0 |
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 71 | 1.587246e-16 | 0 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 30 | 1.451887e-15 | 0 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 24 | 1.485416e-15 | 0 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 30 | 2.232127e-15 | 0 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 30 | 2.430376e-15 | 0 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 20 | 1.391253e-14 | 0 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 51 | 2.465687e-14 | 0 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 248 | 2.581288e-14 | 0 |
| GO:CC | GO:0031090 | organelle membrane | "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] | 102 | 1.158814e-13 | 0 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 45 | 1.878461e-13 | 0 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 233 | 1.523254e-12 | 0 |
| GO:CC | GO:0005832 | chaperonin-containing T-complex | "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] | 8 | 6.103314e-12 | 0 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 179 | 7.004963e-11 | 0 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 71 | 1.409935e-10 | 0 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 27 | 8.010603e-10 | 0 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 27 | 1.374393e-09 | 0 |
| GO:CC | GO:0005759 | mitochondrial matrix | "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] | 29 | 2.075002e-09 | 0 |
| GO:CC | GO:0031967 | organelle envelope | "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] | 47 | 8.790551e-09 | 0 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 132 | 1.065177e-08 | 0 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 132 | 1.065177e-08 | 0 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 132 | 1.065177e-08 | 0 |
| GO:CC | GO:0005783 | endoplasmic reticulum | "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] | 61 | 1.949802e-08 | 0 |
| GO:CC | GO:0035578 | azurophil granule lumen | "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] | 13 | 2.428298e-08 | 0 |
| GO:CC | GO:0042645 | mitochondrial nucleoid | "The region of a mitochondrion to which the DNA is confined." [GOC:jl] | 10 | 6.604155e-08 | 0 |
| GO:CC | GO:0009295 | nucleoid | "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689] | 10 | 6.604155e-08 | 0 |
| GO:CC | GO:0098588 | bounding membrane of organelle | "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] | 61 | 3.436206e-07 | 0 |
| GO:CC | GO:0101031 | protein folding chaperone complex | "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] | 9 | 4.051915e-07 | 0 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 35 | 5.142579e-07 | 0 |
| GO:CC | GO:0140534 | endoplasmic reticulum protein-containing complex | "A protein complex that is part of an endoplasmic reticulum." [GOC:pg] | 13 | 5.333872e-07 | 0 |
| GO:CC | GO:0031966 | mitochondrial membrane | "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] | 32 | 7.574793e-07 | 0 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 64 | 7.677499e-07 | 0 |
| GO:CC | GO:0042582 | azurophil granule | "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule] | 14 | 2.138865e-06 | 0 |
| GO:CC | GO:0005766 | primary lysosome | "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] | 14 | 2.138865e-06 | 0 |
| GO:CC | GO:0000502 | proteasome complex | "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome] | 10 | 2.559536e-06 | 0 |
| GO:CC | GO:0005740 | mitochondrial envelope | "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] | 32 | 3.299126e-06 | 0 |
| GO:CC | GO:0002199 | zona pellucida receptor complex | "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732] | 5 | 4.597348e-06 | 0 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 50 | 4.915913e-06 | 0 |
| GO:CC | GO:0045259 | proton-transporting ATP synthase complex | "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [ISBN:0198547684, ISBN:0716743663] | 6 | 1.107601e-05 | 0 |
| GO:CC | GO:0048471 | perinuclear region of cytoplasm | "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] | 29 | 1.113326e-05 | 0 |
| GO:CC | GO:0005775 | vacuolar lumen | "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] | 14 | 1.447302e-05 | 0 |
| GO:CC | GO:0042175 | nuclear outer membrane-endoplasmic reticulum membrane network | "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] | 39 | 1.988320e-05 | 0 |
| GO:CC | GO:0005743 | mitochondrial inner membrane | "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] | 23 | 2.695321e-05 | 0 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 35 | 2.733049e-05 | 0 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 35 | 3.273864e-05 | 0 |
| GO:CC | GO:0034663 | endoplasmic reticulum chaperone complex | "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] | 5 | 3.681835e-05 | 0 |
| GO:CC | GO:0031968 | organelle outer membrane | "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] | 16 | 3.720138e-05 | 0 |
| GO:CC | GO:0019867 | outer membrane | "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] | 16 | 4.135404e-05 | 0 |
| GO:CC | GO:0019866 | organelle inner membrane | "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] | 24 | 4.442147e-05 | 0 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 22 | 5.289830e-05 | 0 |
| GO:CC | GO:0005838 | proteasome regulatory particle | "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 6 | 6.347722e-05 | 0 |
| GO:CC | GO:0005789 | endoplasmic reticulum membrane | "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] | 37 | 1.014862e-04 | 0 |
| GO:CC | GO:0098827 | endoplasmic reticulum subcompartment | "A distinct region of the endoplasmic reticulum." [GOC:dos] | 37 | 1.142723e-04 | 0 |
| GO:CC | GO:1905369 | endopeptidase complex | "A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 10 | 1.384408e-04 | 0 |
| GO:CC | GO:0022624 | proteasome accessory complex | "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu] | 6 | 1.461611e-04 | 0 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 40 | 2.170137e-04 | 0 |
| GO:CC | GO:0045121 | membrane raft | "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567] | 16 | 2.268647e-04 | 0 |
| GO:CC | GO:0098857 | membrane microdomain | "A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it." [PMID:20044567, PMID:26253820] | 16 | 2.481053e-04 | 0 |
| GO:CC | GO:0005741 | mitochondrial outer membrane | "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] | 14 | 2.513729e-04 | 0 |
| GO:CC | GO:0031984 | organelle subcompartment | "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] | 42 | 2.768016e-04 | 0 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 39 | 6.949877e-04 | 0 |
| GO:CC | GO:0005773 | vacuole | "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] | 28 | 7.999932e-04 | 0 |
| GO:CC | GO:0000323 | lytic vacuole | "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] | 26 | 8.423481e-04 | 0 |
| GO:CC | GO:0005764 | lysosome | "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] | 26 | 8.423481e-04 | 0 |
| GO:CC | GO:0030659 | cytoplasmic vesicle membrane | "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] | 35 | 1.094593e-03 | 0 |
| GO:CC | GO:1905368 | peptidase complex | "A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 10 | 1.413789e-03 | 0 |
| GO:CC | GO:0012506 | vesicle membrane | "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] | 35 | 1.525280e-03 | 0 |
| GO:CC | GO:0098796 | membrane protein complex | "Any protein complex that is part of a membrane." [GOC:dos] | 37 | 1.803188e-03 | 0 |
| GO:CC | GO:0044297 | cell body | "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] | 21 | 2.089532e-03 | 0 |
| GO:CC | GO:0098576 | lumenal side of membrane | "Any side (leaflet) of a membrane that faces the lumen of an organelle." [GOC:dos] | 6 | 3.156840e-03 | 0 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 41 | 3.331617e-03 | 0 |
| GO:CC | GO:0005768 | endosome | "A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] | 30 | 6.970335e-03 | 0 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 25 | 7.865000e-03 | 0 |
| GO:CC | GO:0016469 | proton-transporting two-sector ATPase complex | "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483] | 6 | 9.056951e-03 | 0 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 27 | 1.112467e-02 | 0 |
| GO:CC | GO:0098978 | glutamatergic synapse | "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] | 20 | 1.597631e-02 | 0 |
| GO:CC | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730] | 9 | 1.697034e-02 | 0 |
| GO:CC | GO:0005790 | smooth endoplasmic reticulum | "The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732] | 5 | 1.767329e-02 | 0 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 51 | 2.168242e-02 | 0 |
| GO:CC | GO:0001533 | cornified envelope | "A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes)." [GOC:add, PMID:11112355, PMID:11590230, PMID:15803139] | 6 | 2.902689e-02 | 0 |
| GO:CC | GO:0008541 | proteasome regulatory particle, lid subcomplex | "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb] | 3 | 3.198495e-02 | 0 |
| GO:CC | GO:0042824 | MHC class I peptide loading complex | "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934] | 3 | 4.754970e-02 | 0 |
| GO:CC | GO:1905202 | methylcrotonoyl-CoA carboxylase complex | "A protein complex capable of methylcrotonoyl-CoA carboxylase activity. In mammals, it is a mitochondrial complex comprising a dodecamer of 6 alpha and 6 beta subunits: MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation; MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:bf, GOC:hjd, GOC:PARL, PMID:15868465, PMID:17360195, PMID:22158123, PMID:22869039] | 2 | 4.992364e-02 | 0 |
| GO:CC | GO:0098575 | lumenal side of lysosomal membrane | "The side (leaflet) of the lysosomal membrane that faces the lumen." [GOC:dos] | 2 | 4.992364e-02 | 0 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 82 | 5.674321e-27 | 0 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 76 | 4.138384e-24 | 0 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 72 | 8.590256e-24 | 0 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 72 | 1.744742e-23 | 0 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 71 | 1.328622e-22 | 0 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 67 | 3.804635e-21 | 0 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 63 | 1.654856e-20 | 0 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 64 | 7.782768e-20 | 0 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 67 | 1.413921e-19 | 0 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 64 | 1.003199e-18 | 0 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 58 | 1.754771e-18 | 0 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 55 | 4.417830e-18 | 0 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 61 | 4.971772e-18 | 0 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 57 | 3.056645e-17 | 0 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 57 | 5.200332e-17 | 0 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 57 | 5.181710e-16 | 0 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 166 | 8.556625e-15 | 0 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 53 | 2.456060e-14 | 0 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 142 | 3.510368e-14 | 0 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 50 | 7.768716e-14 | 0 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 49 | 7.867823e-14 | 0 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 49 | 1.473864e-13 | 0 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 148 | 2.026463e-13 | 0 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 51 | 3.499500e-13 | 0 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 48 | 4.039872e-13 | 0 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 78 | 5.302489e-13 | 0 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 49 | 1.273286e-12 | 0 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 194 | 8.604026e-12 | 0 |
| HPA | HPA:0340000 | Ovary | Ovary | 166 | 1.144648e-11 | 0 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 44 | 1.254280e-11 | 0 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 190 | 1.506918e-11 | 0 |
| HPA | HPA:0530000 | Spleen | Spleen | 174 | 2.219934e-11 | 0 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 43 | 2.340567e-11 | 0 |
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 135 | 3.718240e-11 | 0 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 175 | 4.439488e-11 | 0 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 177 | 6.905926e-11 | 0 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 47 | 1.085294e-10 | 0 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 100 | 2.021205e-10 | 0 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 41 | 3.937045e-10 | 0 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 167 | 6.027321e-10 | 0 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 151 | 9.711627e-10 | 0 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 41 | 1.014383e-09 | 0 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 178 | 1.696207e-09 | 0 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 151 | 1.983837e-09 | 0 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 62 | 2.070948e-09 | 0 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 157 | 2.211591e-09 | 0 |
| HPA | HPA:0570802 | Testis; sertoli cells[≥Medium] | Testis; sertoli cells[≥Medium] | 80 | 2.463963e-09 | 0 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 35 | 2.712307e-09 | 0 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 187 | 2.757932e-09 | 0 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 187 | 2.757932e-09 | 0 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 33 | 2.759339e-09 | 0 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 39 | 2.800194e-09 | 0 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 39 | 3.683094e-09 | 0 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 35 | 5.330724e-09 | 0 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 192 | 5.373164e-09 | 0 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 180 | 5.605576e-09 | 0 |
| HPA | HPA:0050000 | Breast | Breast | 191 | 5.735539e-09 | 0 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 158 | 6.025166e-09 | 0 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 175 | 6.718954e-09 | 0 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 175 | 6.718954e-09 | 0 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 182 | 1.014898e-08 | 0 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 182 | 1.014898e-08 | 0 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 200 | 1.033995e-08 | 0 |
| HPA | HPA:0630000 | Cervix | Cervix | 186 | 1.232570e-08 | 0 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 184 | 1.847946e-08 | 0 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 154 | 2.113962e-08 | 0 |
| HPA | HPA:0461451 | Skin 1; hair follicles[≥Low] | Skin 1; hair follicles[≥Low] | 30 | 2.179745e-08 | 0 |
| HPA | HPA:0030000 | Appendix | Appendix | 200 | 2.273743e-08 | 0 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 173 | 2.725815e-08 | 0 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 141 | 2.916617e-08 | 0 |
| HPA | HPA:0291162 | Liver; cholangiocytes[≥Medium] | Liver; cholangiocytes[≥Medium] | 80 | 3.288390e-08 | 0 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 193 | 3.320972e-08 | 0 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 130 | 4.407530e-08 | 0 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 187 | 4.445871e-08 | 0 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 161 | 5.798196e-08 | 0 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 182 | 6.096112e-08 | 0 |
| HPA | HPA:0271142 | Kidney; proximal tubules (cell body)[≥Medium] | Kidney; proximal tubules (cell body)[≥Medium] | 37 | 7.776215e-08 | 0 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 191 | 8.582020e-08 | 0 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 191 | 8.582020e-08 | 0 |
| HPA | HPA:0400000 | Rectum | Rectum | 201 | 8.622014e-08 | 0 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 184 | 8.719026e-08 | 0 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 98 | 1.013413e-07 | 0 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 182 | 1.168877e-07 | 0 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 144 | 1.282920e-07 | 0 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 149 | 1.308576e-07 | 0 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 130 | 1.470963e-07 | 0 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 129 | 1.565833e-07 | 0 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 180 | 1.663373e-07 | 0 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 172 | 1.859083e-07 | 0 |
| HPA | HPA:0080000 | Caudate | Caudate | 184 | 1.938878e-07 | 0 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 167 | 2.029418e-07 | 0 |
| HPA | HPA:0461481 | Skin 1; sebaceous glands[≥Low] | Skin 1; sebaceous glands[≥Low] | 21 | 2.497294e-07 | 0 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 160 | 2.652659e-07 | 0 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 192 | 2.888633e-07 | 0 |
| HPA | HPA:0461421 | Skin 1; eccrine glands[≥Low] | Skin 1; eccrine glands[≥Low] | 23 | 3.123491e-07 | 0 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 115 | 3.972228e-07 | 0 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 80 | 4.277227e-07 | 0 |
| HPA | HPA:0300000 | Lung | Lung | 190 | 4.459412e-07 | 0 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 167 | 4.574556e-07 | 0 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 187 | 4.740289e-07 | 0 |
| HPA | HPA:0570733 | Testis; Leydig cells[High] | Testis; Leydig cells[High] | 72 | 5.356794e-07 | 0 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 29 | 5.457281e-07 | 0 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 124 | 5.482663e-07 | 0 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 124 | 5.482663e-07 | 0 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 130 | 6.236459e-07 | 0 |
| HPA | HPA:0271141 | Kidney; proximal tubules (cell body)[≥Low] | Kidney; proximal tubules (cell body)[≥Low] | 41 | 6.371552e-07 | 0 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 149 | 6.895991e-07 | 0 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 182 | 9.026952e-07 | 0 |
| HPA | HPA:0271133 | Kidney; distal tubules[High] | Kidney; distal tubules[High] | 25 | 1.159894e-06 | 0 |
| HPA | HPA:0271121 | Kidney; collecting ducts[≥Low] | Kidney; collecting ducts[≥Low] | 36 | 1.187377e-06 | 0 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 127 | 1.244103e-06 | 0 |
| HPA | HPA:0271122 | Kidney; collecting ducts[≥Medium] | Kidney; collecting ducts[≥Medium] | 31 | 1.343703e-06 | 0 |
| HPA | HPA:0130000 | Colon | Colon | 204 | 1.529799e-06 | 0 |
| HPA | HPA:0461452 | Skin 1; hair follicles[≥Medium] | Skin 1; hair follicles[≥Medium] | 24 | 1.900748e-06 | 0 |
| HPA | HPA:0481352 | Small intestine; paneth cells[≥Medium] | Small intestine; paneth cells[≥Medium] | 21 | 1.925100e-06 | 0 |
| HPA | HPA:0461482 | Skin 1; sebaceous glands[≥Medium] | Skin 1; sebaceous glands[≥Medium] | 18 | 1.954963e-06 | 0 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 176 | 1.957132e-06 | 0 |
| HPA | HPA:0271132 | Kidney; distal tubules[≥Medium] | Kidney; distal tubules[≥Medium] | 34 | 2.086585e-06 | 0 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 108 | 2.180732e-06 | 0 |
| HPA | HPA:0030071 | Appendix; lymphoid tissue[≥Low] | Appendix; lymphoid tissue[≥Low] | 139 | 2.300113e-06 | 0 |
| HPA | HPA:0461422 | Skin 1; eccrine glands[≥Medium] | Skin 1; eccrine glands[≥Medium] | 19 | 2.408859e-06 | 0 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 163 | 2.509810e-06 | 0 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 187 | 2.575470e-06 | 0 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 187 | 2.575470e-06 | 0 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 62 | 2.997431e-06 | 0 |
| HPA | HPA:0481351 | Small intestine; paneth cells[≥Low] | Small intestine; paneth cells[≥Low] | 22 | 4.667209e-06 | 0 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 26 | 4.724439e-06 | 0 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 157 | 5.423539e-06 | 0 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 188 | 5.836477e-06 | 0 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 172 | 5.945392e-06 | 0 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 172 | 5.945392e-06 | 0 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 122 | 6.119718e-06 | 0 |
| HPA | HPA:0271143 | Kidney; proximal tubules (cell body)[High] | Kidney; proximal tubules (cell body)[High] | 23 | 6.450145e-06 | 0 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 188 | 6.511907e-06 | 0 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 192 | 6.799024e-06 | 0 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 192 | 6.799024e-06 | 0 |
| HPA | HPA:0091001 | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Low] | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Low] | 25 | 7.080324e-06 | 0 |
| HPA | HPA:0270000 | Kidney | Kidney | 201 | 7.220648e-06 | 0 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 199 | 7.340494e-06 | 0 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 81 | 7.397063e-06 | 0 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 149 | 7.469225e-06 | 0 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 144 | 7.738310e-06 | 0 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 117 | 7.772979e-06 | 0 |
| HPA | HPA:0131332 | Colon; mucosal lymphoid cells[≥Medium] | Colon; mucosal lymphoid cells[≥Medium] | 26 | 8.327360e-06 | 0 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 150 | 9.492801e-06 | 0 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 140 | 9.548297e-06 | 0 |
| HPA | HPA:0380000 | Placenta | Placenta | 189 | 1.148255e-05 | 0 |
| HPA | HPA:0151353 | Duodenum; paneth cells[High] | Duodenum; paneth cells[High] | 17 | 1.469776e-05 | 0 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 182 | 1.558146e-05 | 0 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 182 | 1.558146e-05 | 0 |
| HPA | HPA:0151351 | Duodenum; paneth cells[≥Low] | Duodenum; paneth cells[≥Low] | 22 | 1.562720e-05 | 0 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 174 | 1.585794e-05 | 0 |
| HPA | HPA:0390000 | Prostate | Prostate | 174 | 1.585794e-05 | 0 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 126 | 1.629638e-05 | 0 |
| HPA | HPA:0091002 | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium] | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium] | 23 | 1.759720e-05 | 0 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 190 | 1.884690e-05 | 0 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 190 | 1.884690e-05 | 0 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 149 | 1.885705e-05 | 0 |
| HPA | HPA:0510652 | Soft tissue 2; fibroblasts[≥Medium] | Soft tissue 2; fibroblasts[≥Medium] | 89 | 2.282141e-05 | 0 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 26 | 2.561166e-05 | 0 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 28 | 2.600854e-05 | 0 |
| HPA | HPA:0271131 | Kidney; distal tubules[≥Low] | Kidney; distal tubules[≥Low] | 37 | 2.653598e-05 | 0 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 140 | 2.820146e-05 | 0 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 176 | 2.909653e-05 | 0 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 176 | 2.909653e-05 | 0 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 17 | 3.461904e-05 | 0 |
| HPA | HPA:0290000 | Liver | Liver | 166 | 3.650553e-05 | 0 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 194 | 4.028748e-05 | 0 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 134 | 4.116633e-05 | 0 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 124 | 4.187239e-05 | 0 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 59 | 4.610417e-05 | 0 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 26 | 4.687560e-05 | 0 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 27 | 4.895751e-05 | 0 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 186 | 5.019940e-05 | 0 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 128 | 5.418197e-05 | 0 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 163 | 5.425774e-05 | 0 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 138 | 5.801651e-05 | 0 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 52 | 5.853987e-05 | 0 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 152 | 6.163836e-05 | 0 |
| HPA | HPA:0151352 | Duodenum; paneth cells[≥Medium] | Duodenum; paneth cells[≥Medium] | 20 | 6.189737e-05 | 0 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 149 | 6.924694e-05 | 0 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 171 | 7.164215e-05 | 0 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 39 | 7.665138e-05 | 0 |
| HPA | HPA:0471402 | Skin 2; cells in corneal layer[≥Medium] | Skin 2; cells in corneal layer[≥Medium] | 12 | 7.668581e-05 | 0 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 68 | 8.976588e-05 | 0 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 189 | 9.792622e-05 | 0 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 189 | 9.792622e-05 | 0 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 72 | 1.003420e-04 | 0 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 136 | 1.086962e-04 | 0 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 34 | 1.099586e-04 | 0 |
| HPA | HPA:0481353 | Small intestine; paneth cells[High] | Small intestine; paneth cells[High] | 15 | 1.160287e-04 | 0 |
| HPA | HPA:0100211 | Cerebral cortex; neuropil[≥Low] | Cerebral cortex; neuropil[≥Low] | 139 | 1.338178e-04 | 0 |
| HPA | HPA:0031301 | Appendix; enterocytes[≥Low] | Appendix; enterocytes[≥Low] | 28 | 1.368619e-04 | 0 |
| HPA | HPA:0471481 | Skin 2; sebaceous glands[≥Low] | Skin 2; sebaceous glands[≥Low] | 14 | 1.386433e-04 | 0 |
| HPA | HPA:0480892 | Small intestine; goblet cells[≥Medium] | Small intestine; goblet cells[≥Medium] | 23 | 1.392157e-04 | 0 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 88 | 1.523516e-04 | 0 |
| HPA | HPA:0131331 | Colon; mucosal lymphoid cells[≥Low] | Colon; mucosal lymphoid cells[≥Low] | 29 | 1.555131e-04 | 0 |
| HPA | HPA:0401301 | Rectum; enterocytes[≥Low] | Rectum; enterocytes[≥Low] | 29 | 1.755261e-04 | 0 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 131 | 1.773169e-04 | 0 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 72 | 1.878862e-04 | 0 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 156 | 2.125892e-04 | 0 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 156 | 2.125892e-04 | 0 |
| HPA | HPA:0271123 | Kidney; collecting ducts[High] | Kidney; collecting ducts[High] | 20 | 2.230009e-04 | 0 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 109 | 2.309280e-04 | 0 |
| HPA | HPA:0471401 | Skin 2; cells in corneal layer[≥Low] | Skin 2; cells in corneal layer[≥Low] | 14 | 2.393443e-04 | 0 |
| HPA | HPA:0131302 | Colon; enterocytes[≥Medium] | Colon; enterocytes[≥Medium] | 24 | 2.546789e-04 | 0 |
| HPA | HPA:0131291 | Colon; endocrine cells[≥Low] | Colon; endocrine cells[≥Low] | 26 | 3.812518e-04 | 0 |
| HPA | HPA:0150892 | Duodenum; goblet cells[≥Medium] | Duodenum; goblet cells[≥Medium] | 22 | 3.915699e-04 | 0 |
| HPA | HPA:0151303 | Duodenum; enterocytes[High] | Duodenum; enterocytes[High] | 18 | 4.036601e-04 | 0 |
| HPA | HPA:0131301 | Colon; enterocytes[≥Low] | Colon; enterocytes[≥Low] | 28 | 4.098641e-04 | 0 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 191 | 4.100268e-04 | 0 |
| HPA | HPA:0031291 | Appendix; endocrine cells[≥Low] | Appendix; endocrine cells[≥Low] | 25 | 4.230771e-04 | 0 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 137 | 4.331058e-04 | 0 |
| HPA | HPA:0030431 | Appendix; germinal center cells[≥Low] | Appendix; germinal center cells[≥Low] | 20 | 4.618855e-04 | 0 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 81 | 4.631290e-04 | 0 |
| HPA | HPA:0570000 | Testis | Testis | 209 | 4.684397e-04 | 0 |
| HPA | HPA:0151301 | Duodenum; enterocytes[≥Low] | Duodenum; enterocytes[≥Low] | 29 | 4.800869e-04 | 0 |
| HPA | HPA:0091071 | Cerebellum; white matter cells - cytoplasm/membrane[≥Low] | Cerebellum; white matter cells - cytoplasm/membrane[≥Low] | 20 | 4.875713e-04 | 0 |
| HPA | HPA:0461423 | Skin 1; eccrine glands[High] | Skin 1; eccrine glands[High] | 11 | 5.271835e-04 | 0 |
| HPA | HPA:0401331 | Rectum; mucosal lymphoid cells[≥Low] | Rectum; mucosal lymphoid cells[≥Low] | 29 | 5.776726e-04 | 0 |
| HPA | HPA:0131292 | Colon; endocrine cells[≥Medium] | Colon; endocrine cells[≥Medium] | 24 | 6.592918e-04 | 0 |
| HPA | HPA:0481292 | Small intestine; endocrine cells[≥Medium] | Small intestine; endocrine cells[≥Medium] | 26 | 6.781964e-04 | 0 |
| HPA | HPA:0290402 | Liver; hepatocytes[≥Medium] | Liver; hepatocytes[≥Medium] | 110 | 7.118945e-04 | 0 |
| HPA | HPA:0271111 | Kidney; bowman's capsule[≥Low] | Kidney; bowman's capsule[≥Low] | 19 | 7.337461e-04 | 0 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 121 | 7.483346e-04 | 0 |
| HPA | HPA:0401292 | Rectum; endocrine cells[≥Medium] | Rectum; endocrine cells[≥Medium] | 24 | 7.508004e-04 | 0 |
| HPA | HPA:0481303 | Small intestine; enterocytes[High] | Small intestine; enterocytes[High] | 18 | 7.797663e-04 | 0 |
| HPA | HPA:0100212 | Cerebral cortex; neuropil[≥Medium] | Cerebral cortex; neuropil[≥Medium] | 84 | 8.333460e-04 | 0 |
| HPA | HPA:0091072 | Cerebellum; white matter cells - cytoplasm/membrane[≥Medium] | Cerebellum; white matter cells - cytoplasm/membrane[≥Medium] | 17 | 8.499854e-04 | 0 |
| HPA | HPA:0480891 | Small intestine; goblet cells[≥Low] | Small intestine; goblet cells[≥Low] | 24 | 9.695976e-04 | 0 |
| HPA | HPA:0400891 | Rectum; goblet cells[≥Low] | Rectum; goblet cells[≥Low] | 24 | 9.695976e-04 | 0 |
| HPA | HPA:0131333 | Colon; mucosal lymphoid cells[High] | Colon; mucosal lymphoid cells[High] | 14 | 1.043318e-03 | 0 |
| HPA | HPA:0530712 | Spleen; cells in red pulp[≥Medium] | Spleen; cells in red pulp[≥Medium] | 96 | 1.053785e-03 | 0 |
| HPA | HPA:0151342 | Duodenum; glands of Brunner[≥Medium] | Duodenum; glands of Brunner[≥Medium] | 16 | 1.154979e-03 | 0 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 139 | 1.256145e-03 | 0 |
| HPA | HPA:0130893 | Colon; goblet cells[High] | Colon; goblet cells[High] | 16 | 1.311028e-03 | 0 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 92 | 1.374035e-03 | 0 |
| HPA | HPA:0151292 | Duodenum; endocrine cells[≥Medium] | Duodenum; endocrine cells[≥Medium] | 25 | 1.401026e-03 | 0 |
| HPA | HPA:0150893 | Duodenum; goblet cells[High] | Duodenum; goblet cells[High] | 16 | 1.485718e-03 | 0 |
| HPA | HPA:0481301 | Small intestine; enterocytes[≥Low] | Small intestine; enterocytes[≥Low] | 29 | 1.501780e-03 | 0 |
| HPA | HPA:0401291 | Rectum; endocrine cells[≥Low] | Rectum; endocrine cells[≥Low] | 25 | 1.515137e-03 | 0 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 76 | 1.539306e-03 | 0 |
| HPA | HPA:0620000 | Vagina | Vagina | 155 | 1.689131e-03 | 0 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 155 | 1.689131e-03 | 0 |
| HPA | HPA:0290401 | Liver; hepatocytes[≥Low] | Liver; hepatocytes[≥Low] | 150 | 1.753209e-03 | 0 |
| HPA | HPA:0031303 | Appendix; enterocytes[High] | Appendix; enterocytes[High] | 15 | 2.139382e-03 | 0 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 168 | 2.232005e-03 | 0 |
| HPA | HPA:0151343 | Duodenum; glands of Brunner[High] | Duodenum; glands of Brunner[High] | 11 | 2.460534e-03 | 0 |
| HPA | HPA:0151341 | Duodenum; glands of Brunner[≥Low] | Duodenum; glands of Brunner[≥Low] | 18 | 2.466142e-03 | 0 |
| HPA | HPA:0481291 | Small intestine; endocrine cells[≥Low] | Small intestine; endocrine cells[≥Low] | 26 | 2.475253e-03 | 0 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 20 | 2.539262e-03 | 0 |
| HPA | HPA:0131303 | Colon; enterocytes[High] | Colon; enterocytes[High] | 16 | 2.712328e-03 | 0 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 19 | 2.941900e-03 | 0 |
| HPA | HPA:0130651 | Colon; fibroblasts[≥Low] | Colon; fibroblasts[≥Low] | 11 | 2.958765e-03 | 0 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 114 | 2.988669e-03 | 0 |
| HPA | HPA:0220053 | Gallbladder; glandular cells[High] | Gallbladder; glandular cells[High] | 88 | 3.040666e-03 | 0 |
| HPA | HPA:0130891 | Colon; goblet cells[≥Low] | Colon; goblet cells[≥Low] | 23 | 3.412219e-03 | 0 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 140 | 3.490699e-03 | 0 |
| HPA | HPA:0030891 | Appendix; goblet cells[≥Low] | Appendix; goblet cells[≥Low] | 22 | 3.709390e-03 | 0 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 132 | 3.729030e-03 | 0 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 17 | 3.730874e-03 | 0 |
| HPA | HPA:0510701 | Soft tissue 2; peripheral nerve[≥Low] | Soft tissue 2; peripheral nerve[≥Low] | 95 | 4.021749e-03 | 0 |
| HPA | HPA:0031302 | Appendix; enterocytes[≥Medium] | Appendix; enterocytes[≥Medium] | 21 | 4.695803e-03 | 0 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 20 | 4.972226e-03 | 0 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 50 | 5.039584e-03 | 0 |
| HPA | HPA:0031293 | Appendix; endocrine cells[High] | Appendix; endocrine cells[High] | 16 | 5.042236e-03 | 0 |
| HPA | HPA:0271112 | Kidney; bowman's capsule[≥Medium] | Kidney; bowman's capsule[≥Medium] | 15 | 5.050821e-03 | 0 |
| HPA | HPA:0130653 | Colon; fibroblasts[High] | Colon; fibroblasts[High] | 8 | 5.375316e-03 | 0 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 53 | 5.416707e-03 | 0 |
| HPA | HPA:0030893 | Appendix; goblet cells[High] | Appendix; goblet cells[High] | 14 | 5.444561e-03 | 0 |
| HPA | HPA:0461401 | Skin 1; cells in corneal layer[≥Low] | Skin 1; cells in corneal layer[≥Low] | 10 | 5.487631e-03 | 0 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 148 | 5.739549e-03 | 0 |
| HPA | HPA:0360053 | Parathyroid gland; glandular cells[High] | Parathyroid gland; glandular cells[High] | 55 | 5.925372e-03 | 0 |
| HPA | HPA:0060101 | Bronchus; respiratory epithelial cells[≥Low] | Bronchus; respiratory epithelial cells[≥Low] | 151 | 6.812765e-03 | 0 |
| HPA | HPA:0400241 | Rectum; peripheral nerve/ganglion[≥Low] | Rectum; peripheral nerve/ganglion[≥Low] | 17 | 6.882899e-03 | 0 |
| HPA | HPA:0400892 | Rectum; goblet cells[≥Medium] | Rectum; goblet cells[≥Medium] | 20 | 6.990818e-03 | 0 |
| HPA | HPA:0151291 | Duodenum; endocrine cells[≥Low] | Duodenum; endocrine cells[≥Low] | 25 | 6.997815e-03 | 0 |
| HPA | HPA:0130652 | Colon; fibroblasts[≥Medium] | Colon; fibroblasts[≥Medium] | 10 | 7.262626e-03 | 0 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 63 | 7.493027e-03 | 0 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 17 | 7.593200e-03 | 0 |
| HPA | HPA:0500112 | Soft tissue 1; chondrocytes[≥Medium] | Soft tissue 1; chondrocytes[≥Medium] | 52 | 7.706925e-03 | 0 |
| HPA | HPA:0150891 | Duodenum; goblet cells[≥Low] | Duodenum; goblet cells[≥Low] | 22 | 7.811710e-03 | 0 |
| HPA | HPA:0090181 | Cerebellum; cells in granular layer[≥Low] | Cerebellum; cells in granular layer[≥Low] | 123 | 8.413414e-03 | 0 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 175 | 8.530811e-03 | 0 |
| HPA | HPA:0570731 | Testis; Leydig cells[≥Low] | Testis; Leydig cells[≥Low] | 174 | 8.700493e-03 | 0 |
| HPA | HPA:0091073 | Cerebellum; white matter cells - cytoplasm/membrane[High] | Cerebellum; white matter cells - cytoplasm/membrane[High] | 11 | 8.890801e-03 | 0 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 119 | 8.909219e-03 | 0 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 121 | 9.162848e-03 | 0 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 17 | 9.212232e-03 | 0 |
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 30 | 9.328691e-03 | 0 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 127 | 9.414749e-03 | 0 |
| HPA | HPA:0090941 | Cerebellum; Purkinje cells - cytoplasm/membrane[≥Low] | Cerebellum; Purkinje cells - cytoplasm/membrane[≥Low] | 23 | 1.005801e-02 | 0 |
| HPA | HPA:0010012 | Adipose tissue; adipocytes[≥Medium] | Adipose tissue; adipocytes[≥Medium] | 71 | 1.132304e-02 | 0 |
| HPA | HPA:0400653 | Rectum; fibroblasts[High] | Rectum; fibroblasts[High] | 8 | 1.133846e-02 | 0 |
| HPA | HPA:0241101 | Heart muscle; cardiomyocytes[≥Low] | Heart muscle; cardiomyocytes[≥Low] | 158 | 1.292440e-02 | 0 |
| HPA | HPA:0240000 | Heart muscle | Heart muscle | 158 | 1.292440e-02 | 0 |
| HPA | HPA:0461483 | Skin 1; sebaceous glands[High] | Skin 1; sebaceous glands[High] | 9 | 1.345237e-02 | 0 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 16 | 1.409227e-02 | 0 |
| HPA | HPA:0151293 | Duodenum; endocrine cells[High] | Duodenum; endocrine cells[High] | 18 | 1.414929e-02 | 0 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 60 | 1.527102e-02 | 0 |
| HPA | HPA:0131293 | Colon; endocrine cells[High] | Colon; endocrine cells[High] | 16 | 1.551791e-02 | 0 |
| HPA | HPA:0300413 | Lung; macrophages[High] | Lung; macrophages[High] | 49 | 1.587593e-02 | 0 |
| HPA | HPA:0130892 | Colon; goblet cells[≥Medium] | Colon; goblet cells[≥Medium] | 19 | 1.701061e-02 | 0 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 83 | 1.787663e-02 | 0 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 51 | 1.827205e-02 | 0 |
| HPA | HPA:0031292 | Appendix; endocrine cells[≥Medium] | Appendix; endocrine cells[≥Medium] | 20 | 1.886742e-02 | 0 |
| HPA | HPA:0500111 | Soft tissue 1; chondrocytes[≥Low] | Soft tissue 1; chondrocytes[≥Low] | 69 | 1.926229e-02 | 0 |
| HPA | HPA:0090922 | Cerebellum; GLUC cells - cytoplasm/membrane[≥Medium] | Cerebellum; GLUC cells - cytoplasm/membrane[≥Medium] | 13 | 1.965043e-02 | 0 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 140 | 1.983688e-02 | 0 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 140 | 1.983688e-02 | 0 |
| HPA | HPA:0090972 | Cerebellum; granular cells - cytoplasm/membrane[≥Medium] | Cerebellum; granular cells - cytoplasm/membrane[≥Medium] | 15 | 2.046828e-02 | 0 |
| HPA | HPA:0030892 | Appendix; goblet cells[≥Medium] | Appendix; goblet cells[≥Medium] | 18 | 2.243469e-02 | 0 |
| HPA | HPA:0471482 | Skin 2; sebaceous glands[≥Medium] | Skin 2; sebaceous glands[≥Medium] | 10 | 2.353404e-02 | 0 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 71 | 2.369896e-02 | 0 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 18 | 2.433359e-02 | 0 |
| HPA | HPA:0381201 | Placenta; hofbauer cells[≥Low] | Placenta; hofbauer cells[≥Low] | 22 | 2.443264e-02 | 0 |
| HPA | HPA:0480893 | Small intestine; goblet cells[High] | Small intestine; goblet cells[High] | 14 | 2.536392e-02 | 0 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 103 | 2.679062e-02 | 0 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 81 | 2.809418e-02 | 0 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 74 | 2.967468e-02 | 0 |
| HPA | HPA:0381202 | Placenta; hofbauer cells[≥Medium] | Placenta; hofbauer cells[≥Medium] | 20 | 3.039515e-02 | 0 |
| HPA | HPA:0291163 | Liver; cholangiocytes[High] | Liver; cholangiocytes[High] | 18 | 3.090988e-02 | 0 |
| HPA | HPA:0381191 | Placenta; cytotrophoblasts[≥Low] | Placenta; cytotrophoblasts[≥Low] | 23 | 3.226761e-02 | 0 |
| HPA | HPA:0400893 | Rectum; goblet cells[High] | Rectum; goblet cells[High] | 14 | 3.272562e-02 | 0 |
| HPA | HPA:0381193 | Placenta; cytotrophoblasts[High] | Placenta; cytotrophoblasts[High] | 17 | 3.334337e-02 | 0 |
| HPA | HPA:0090971 | Cerebellum; granular cells - cytoplasm/membrane[≥Low] | Cerebellum; granular cells - cytoplasm/membrane[≥Low] | 17 | 3.334337e-02 | 0 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 103 | 3.594947e-02 | 0 |
| HPA | HPA:0500701 | Soft tissue 1; peripheral nerve[≥Low] | Soft tissue 1; peripheral nerve[≥Low] | 82 | 3.863271e-02 | 0 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 88 | 4.105621e-02 | 0 |
| HPA | HPA:0080123 | Caudate; glial cells[High] | Caudate; glial cells[High] | 29 | 4.144700e-02 | 0 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 111 | 4.234823e-02 | 0 |
| HPA | HPA:0400242 | Rectum; peripheral nerve/ganglion[≥Medium] | Rectum; peripheral nerve/ganglion[≥Medium] | 13 | 4.478368e-02 | 0 |
| HPA | HPA:0381222 | Placenta; syncytiotrophoblasts - microvilli[≥Medium] | Placenta; syncytiotrophoblasts - microvilli[≥Medium] | 17 | 4.789410e-02 | 0 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 174 | 3.314691e-23 | 0 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 100 | 1.596730e-22 | 0 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 98 | 1.059847e-19 | 0 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 92 | 2.512334e-19 | 0 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 258 | 2.983073e-19 | 0 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 90 | 2.328172e-18 | 0 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 86 | 4.809039e-18 | 0 |
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 14 | 3.288794e-16 | 0 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 21 | 8.179914e-16 | 0 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 80 | 1.680547e-15 | 0 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 87 | 3.622376e-15 | 0 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 79 | 3.881968e-15 | 0 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 31 | 7.050350e-15 | 0 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 17 | 7.301381e-15 | 0 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 76 | 3.648320e-14 | 0 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 38 | 5.915078e-14 | 0 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 65 | 2.932945e-13 | 0 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 146 | 2.888746e-11 | 0 |
| GO:MF | GO:0016491 | oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-] | 40 | 3.284713e-11 | 0 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 58 | 1.687860e-10 | 0 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 56 | 6.454240e-10 | 0 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 24 | 1.323116e-09 | 0 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 24 | 4.451466e-09 | 0 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 47 | 7.981380e-09 | 0 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 66 | 3.353860e-08 | 0 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 135 | 3.357593e-08 | 0 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 47 | 4.177595e-08 | 0 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 47 | 4.290237e-08 | 0 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 47 | 4.290237e-08 | 0 |
| GO:MF | GO:0016874 | ligase activity | "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-] | 17 | 8.578137e-08 | 0 |
| GO:MF | GO:0016836 | hydro-lyase activity | "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-] | 11 | 1.194267e-07 | 0 |
| GO:MF | GO:0016835 | carbon-oxygen lyase activity | "Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-] | 12 | 1.628490e-07 | 0 |
| GO:MF | GO:0016787 | hydrolase activity | "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] | 83 | 3.265970e-07 | 0 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 23 | 2.914838e-06 | 0 |
| GO:MF | GO:0016829 | lyase activity | "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-] | 16 | 2.415364e-05 | 0 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 265 | 3.455861e-05 | 0 |
| GO:MF | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism | "Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722] | 6 | 3.472392e-05 | 0 |
| GO:MF | GO:0042288 | MHC class I protein binding | "Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] | 6 | 3.472392e-05 | 0 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 42 | 3.969335e-05 | 0 |
| GO:MF | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-] | 12 | 4.068693e-05 | 0 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 57 | 4.809903e-05 | 0 |
| GO:MF | GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] | 12 | 9.575787e-05 | 0 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 26 | 1.210835e-04 | 0 |
| GO:MF | GO:0043531 | ADP binding | "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl] | 8 | 1.889007e-04 | 0 |
| GO:MF | GO:0016860 | intramolecular oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators] | 8 | 2.925439e-04 | 0 |
| GO:MF | GO:0015252 | proton channel activity | "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] | 6 | 6.305209e-04 | 0 |
| GO:MF | GO:0051920 | peroxiredoxin activity | "Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH." [RHEA:10008] | 4 | 8.469483e-04 | 0 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 32 | 1.576702e-03 | 0 |
| GO:MF | GO:0015035 | protein-disulfide reductase activity | "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385] | 6 | 2.105797e-03 | 0 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 69 | 2.266489e-03 | 0 |
| GO:MF | GO:0051287 | NAD binding | "Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] | 7 | 2.535630e-03 | 0 |
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 19 | 3.152158e-03 | 0 |
| GO:MF | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors | "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.8.-.-, GOC:ai] | 7 | 3.263728e-03 | 0 |
| GO:MF | GO:0004601 | peroxidase activity | "Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators] | 7 | 4.157427e-03 | 0 |
| GO:MF | GO:0051087 | protein-folding chaperone binding | "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443] | 10 | 5.069055e-03 | 0 |
| GO:MF | GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor | "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [EC:1.11.-.-] | 7 | 5.245032e-03 | 0 |
| GO:MF | GO:0015036 | disulfide oxidoreductase activity | "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [GOC:curators] | 6 | 5.623111e-03 | 0 |
| GO:MF | GO:0042287 | MHC protein binding | "Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] | 6 | 5.623111e-03 | 0 |
| GO:MF | GO:0016209 | antioxidant activity | "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] | 8 | 7.119572e-03 | 0 |
| GO:MF | GO:0032561 | guanyl ribonucleotide binding | "Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 23 | 8.517928e-03 | 0 |
| GO:MF | GO:0019001 | guanyl nucleotide binding | "Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732] | 23 | 8.517928e-03 | 0 |
| GO:MF | GO:0005200 | structural constituent of cytoskeleton | "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] | 9 | 8.851631e-03 | 0 |
| GO:MF | GO:0008289 | lipid binding | "Binding to a lipid." [GOC:ai] | 27 | 1.224396e-02 | 0 |
| GO:MF | GO:0019842 | vitamin binding | "Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] | 10 | 1.351363e-02 | 0 |
| GO:MF | GO:0140824 | thioredoxin-dependent peroxiredoxin activity | "Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O." [PMID:12707274, PMID:19820102, RHEA:62620] | 3 | 1.871459e-02 | 0 |
| GO:MF | GO:0008379 | thioredoxin peroxidase activity | "Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O." [RHEA:63528] | 3 | 1.871459e-02 | 0 |
| GO:MF | GO:0016421 | CoA carboxylase activity | "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah] | 3 | 1.871459e-02 | 0 |
| GO:MF | GO:0016879 | ligase activity, forming carbon-nitrogen bonds | "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3.-.-] | 6 | 2.083975e-02 | 0 |
| GO:MF | GO:0048029 | monosaccharide binding | "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid] | 7 | 3.019815e-02 | 0 |
| GO:MF | GO:0005525 | GTP binding | "Binding to GTP, guanosine triphosphate." [GOC:ai] | 21 | 3.123844e-02 | 0 |
| GO:MF | GO:0016885 | ligase activity, forming carbon-carbon bonds | "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4.-.-] | 3 | 3.242958e-02 | 0 |
| GO:MF | GO:0003756 | protein disulfide isomerase activity | "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function] | 4 | 4.180411e-02 | 0 |
| GO:MF | GO:0016864 | intramolecular oxidoreductase activity, transposing S-S bonds | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4.-, GOC:mah] | 4 | 4.180411e-02 | 0 |
| GO:MF | GO:0051015 | actin filament binding | "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] | 11 | 4.741804e-02 | 0 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0044281 | small molecule metabolic process | "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] | 79 | 6.572680e-21 | 0 |
| GO:BP | GO:0009117 | nucleotide metabolic process | "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] | 42 | 1.341003e-19 | 0 |
| GO:BP | GO:0006753 | nucleoside phosphate metabolic process | "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] | 47 | 2.258589e-19 | 0 |
| GO:BP | GO:0055086 | nucleobase-containing small molecule metabolic process | "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] | 47 | 1.252361e-18 | 0 |
| GO:BP | GO:0006163 | purine nucleotide metabolic process | "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 38 | 5.066080e-18 | 0 |
| GO:BP | GO:0072521 | purine-containing compound metabolic process | "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 42 | 2.121884e-17 | 0 |
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 25 | 2.046089e-16 | 0 |
| GO:BP | GO:0043436 | oxoacid metabolic process | "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] | 51 | 2.721172e-16 | 0 |
| GO:BP | GO:0006082 | organic acid metabolic process | "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] | 51 | 3.610382e-16 | 0 |
| GO:BP | GO:0019752 | carboxylic acid metabolic process | "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] | 50 | 5.391772e-16 | 0 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 27 | 8.500473e-16 | 0 |
| GO:BP | GO:0009141 | nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 29 | 3.349443e-15 | 0 |
| GO:BP | GO:0009199 | ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 28 | 6.996628e-15 | 0 |
| GO:BP | GO:0019362 | pyridine nucleotide metabolic process | "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] | 23 | 1.633212e-14 | 0 |
| GO:BP | GO:0046496 | nicotinamide nucleotide metabolic process | "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] | 23 | 1.633212e-14 | 0 |
| GO:BP | GO:0009259 | ribonucleotide metabolic process | "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 32 | 1.998315e-14 | 0 |
| GO:BP | GO:0019693 | ribose phosphate metabolic process | "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 32 | 3.727298e-14 | 0 |
| GO:BP | GO:0019637 | organophosphate metabolic process | "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] | 52 | 7.149432e-14 | 0 |
| GO:BP | GO:0009144 | purine nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 27 | 7.316033e-14 | 0 |
| GO:BP | GO:0009150 | purine ribonucleotide metabolic process | "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 30 | 2.687514e-13 | 0 |
| GO:BP | GO:0009205 | purine ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 26 | 3.746525e-13 | 0 |
| GO:BP | GO:0051086 | chaperone mediated protein folding independent of cofactor | "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] | 8 | 1.208077e-12 | 0 |
| GO:BP | GO:0006458 | 'de novo' protein folding | "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] | 14 | 1.227800e-12 | 0 |
| GO:BP | GO:0051084 | 'de novo' post-translational protein folding | "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] | 13 | 8.154453e-12 | 0 |
| GO:BP | GO:1904874 | positive regulation of telomerase RNA localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.075498e-11 | 0 |
| GO:BP | GO:0006091 | generation of precursor metabolites and energy | "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] | 32 | 2.614430e-11 | 0 |
| GO:BP | GO:0046034 | ATP metabolic process | "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] | 23 | 3.655758e-11 | 0 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 15 | 4.177276e-11 | 0 |
| GO:BP | GO:1904869 | regulation of protein localization to Cajal body | "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 5.319275e-11 | 0 |
| GO:BP | GO:1904871 | positive regulation of protein localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 5.319275e-11 | 0 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 79 | 1.057526e-10 | 0 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 33 | 1.235323e-10 | 0 |
| GO:BP | GO:0032787 | monocarboxylic acid metabolic process | "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] | 35 | 1.812946e-10 | 0 |
| GO:BP | GO:1901135 | carbohydrate derivative metabolic process | "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] | 44 | 3.938869e-10 | 0 |
| GO:BP | GO:1903405 | protein localization to nuclear body | "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849] | 8 | 5.725220e-10 | 0 |
| GO:BP | GO:1904867 | protein localization to Cajal body | "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 5.725220e-10 | 0 |
| GO:BP | GO:1904872 | regulation of telomerase RNA localization to Cajal body | "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 5.725220e-10 | 0 |
| GO:BP | GO:0006090 | pyruvate metabolic process | "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] | 17 | 6.470322e-10 | 0 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 93 | 1.600352e-09 | 0 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 72 | 2.233755e-09 | 0 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 25 | 2.259496e-09 | 0 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 72 | 2.373395e-09 | 0 |
| GO:BP | GO:1990173 | protein localization to nucleoplasm | "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952] | 8 | 3.398530e-09 | 0 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 110 | 4.029151e-09 | 0 |
| GO:BP | GO:0072526 | pyridine-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 15 | 5.842871e-09 | 0 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 63 | 8.304759e-09 | 0 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 85 | 1.028024e-08 | 0 |
| GO:BP | GO:0009185 | ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 16 | 1.095672e-08 | 0 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 121 | 1.568357e-08 | 0 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 20 | 1.776056e-08 | 0 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 44 | 2.040579e-08 | 0 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 62 | 2.345813e-08 | 0 |
| GO:BP | GO:0009132 | nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 16 | 2.541464e-08 | 0 |
| GO:BP | GO:0072523 | purine-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 17 | 2.579638e-08 | 0 |
| GO:BP | GO:0006096 | glycolytic process | "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] | 14 | 3.079174e-08 | 0 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 39 | 3.498920e-08 | 0 |
| GO:BP | GO:0046032 | ADP catabolic process | "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators] | 14 | 4.119957e-08 | 0 |
| GO:BP | GO:0006195 | purine nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 16 | 4.494056e-08 | 0 |
| GO:BP | GO:1901292 | nucleoside phosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie] | 18 | 4.830668e-08 | 0 |
| GO:BP | GO:0009166 | nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] | 17 | 5.265045e-08 | 0 |
| GO:BP | GO:0019364 | pyridine nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw] | 14 | 5.474737e-08 | 0 |
| GO:BP | GO:0009181 | purine ribonucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 14 | 6.295333e-08 | 0 |
| GO:BP | GO:0009137 | purine nucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 14 | 6.295333e-08 | 0 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 58 | 7.025636e-08 | 0 |
| GO:BP | GO:0090672 | telomerase RNA localization | "Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 8 | 8.100916e-08 | 0 |
| GO:BP | GO:0090671 | telomerase RNA localization to Cajal body | "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 8 | 8.100916e-08 | 0 |
| GO:BP | GO:0090685 | RNA localization to nucleus | "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] | 8 | 8.100916e-08 | 0 |
| GO:BP | GO:0090670 | RNA localization to Cajal body | "A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 8 | 8.100916e-08 | 0 |
| GO:BP | GO:0009191 | ribonucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 14 | 9.480855e-08 | 0 |
| GO:BP | GO:0046434 | organophosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai] | 20 | 9.804334e-08 | 0 |
| GO:BP | GO:0046031 | ADP metabolic process | "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators] | 14 | 1.083409e-07 | 0 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 51 | 1.376029e-07 | 0 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 94 | 1.442216e-07 | 0 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 50 | 1.557549e-07 | 0 |
| GO:BP | GO:0009134 | nucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 14 | 1.602588e-07 | 0 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 59 | 1.668091e-07 | 0 |
| GO:BP | GO:0009154 | purine ribonucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 15 | 1.852907e-07 | 0 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 37 | 2.041265e-07 | 0 |
| GO:BP | GO:0044283 | small molecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] | 30 | 2.164581e-07 | 0 |
| GO:BP | GO:0009261 | ribonucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 15 | 3.960782e-07 | 0 |
| GO:BP | GO:0009179 | purine ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 14 | 4.824575e-07 | 0 |
| GO:BP | GO:0009135 | purine nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 14 | 4.824575e-07 | 0 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 37 | 5.770467e-07 | 0 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 73 | 6.039437e-07 | 0 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 73 | 7.351396e-07 | 0 |
| GO:BP | GO:0032212 | positive regulation of telomere maintenance via telomerase | "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 8 | 7.465739e-07 | 0 |
| GO:BP | GO:0051234 | establishment of localization | "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] | 107 | 8.769226e-07 | 0 |
| GO:BP | GO:1901293 | nucleoside phosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie] | 21 | 1.190321e-06 | 0 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 26 | 1.655804e-06 | 0 |
| GO:BP | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 8 | 2.181300e-06 | 0 |
| GO:BP | GO:0006810 | transport | "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] | 98 | 2.203018e-06 | 0 |
| GO:BP | GO:0007339 | binding of sperm to zona pellucida | "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] | 9 | 2.863769e-06 | 0 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 86 | 2.926704e-06 | 0 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 41 | 3.000965e-06 | 0 |
| GO:BP | GO:0015031 | protein transport | "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 47 | 3.239585e-06 | 0 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 19 | 3.493834e-06 | 0 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 42 | 4.181092e-06 | 0 |
| GO:BP | GO:0042221 | response to chemical | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] | 89 | 6.378106e-06 | 0 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 48 | 6.807616e-06 | 0 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 73 | 9.504258e-06 | 0 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 57 | 1.015725e-05 | 0 |
| GO:BP | GO:1903829 | positive regulation of protein localization | "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 25 | 1.051685e-05 | 0 |
| GO:BP | GO:0016052 | carbohydrate catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] | 15 | 1.154971e-05 | 0 |
| GO:BP | GO:0009165 | nucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] | 17 | 1.161141e-05 | 0 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 37 | 1.167568e-05 | 0 |
| GO:BP | GO:0009260 | ribonucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 15 | 1.461443e-05 | 0 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 159 | 1.642808e-05 | 0 |
| GO:BP | GO:0006734 | NADH metabolic process | "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] | 8 | 1.653295e-05 | 0 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 44 | 2.239083e-05 | 0 |
| GO:BP | GO:0046390 | ribose phosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 15 | 2.485410e-05 | 0 |
| GO:BP | GO:0005975 | carbohydrate metabolic process | "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] | 26 | 2.535718e-05 | 0 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 63 | 2.996969e-05 | 0 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 32 | 3.471372e-05 | 0 |
| GO:BP | GO:0045184 | establishment of protein localization | "The directed movement of a protein to a specific location." [GOC:bf] | 54 | 3.719822e-05 | 0 |
| GO:BP | GO:0035036 | sperm-egg recognition | "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf] | 9 | 4.025465e-05 | 0 |
| GO:BP | GO:0005996 | monosaccharide metabolic process | "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732] | 17 | 4.299617e-05 | 0 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 25 | 5.601501e-05 | 0 |
| GO:BP | GO:0019318 | hexose metabolic process | "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] | 16 | 6.454051e-05 | 0 |
| GO:BP | GO:0072522 | purine-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 17 | 6.457418e-05 | 0 |
| GO:BP | GO:1901136 | carbohydrate derivative catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie] | 17 | 6.457418e-05 | 0 |
| GO:BP | GO:0009988 | cell-cell recognition | "Cell recognition between cells. May involve the formation of specialized cell junctions." [ISBN:0824072820] | 10 | 7.225692e-05 | 0 |
| GO:BP | GO:0009201 | ribonucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 12 | 7.503243e-05 | 0 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 29 | 1.005988e-04 | 0 |
| GO:BP | GO:0006886 | intracellular protein transport | "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] | 28 | 1.021083e-04 | 0 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 9 | 1.243819e-04 | 0 |
| GO:BP | GO:0061621 | canonical glycolysis | "The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479] | 6 | 1.316421e-04 | 0 |
| GO:BP | GO:0061718 | glucose catabolic process to pyruvate | "The chemical reactions and pathways resulting in the breakdown of glucose, with the production of pyruvate." [GOC:dph] | 6 | 1.316421e-04 | 0 |
| GO:BP | GO:0009142 | nucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 12 | 1.555859e-04 | 0 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 24 | 1.753155e-04 | 0 |
| GO:BP | GO:0090407 | organophosphate biosynthetic process | "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg] | 26 | 1.814410e-04 | 0 |
| GO:BP | GO:0070201 | regulation of establishment of protein localization | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] | 24 | 1.878785e-04 | 0 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 9 | 1.927063e-04 | 0 |
| GO:BP | GO:0006006 | glucose metabolic process | "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] | 14 | 1.966527e-04 | 0 |
| GO:BP | GO:0032210 | regulation of telomere maintenance via telomerase | "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 8 | 2.085928e-04 | 0 |
| GO:BP | GO:0061620 | glycolytic process through glucose-6-phosphate | "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479] | 6 | 2.691172e-04 | 0 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 18 | 2.697966e-04 | 0 |
| GO:BP | GO:0009152 | purine ribonucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 13 | 2.856819e-04 | 0 |
| GO:BP | GO:0046394 | carboxylic acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] | 18 | 2.962726e-04 | 0 |
| GO:BP | GO:0016053 | organic acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] | 18 | 3.404636e-04 | 0 |
| GO:BP | GO:0007005 | mitochondrion organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] | 21 | 3.509278e-04 | 0 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] | 56 | 3.759128e-04 | 0 |
| GO:BP | GO:1901607 | alpha-amino acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie] | 9 | 3.798994e-04 | 0 |
| GO:BP | GO:0034975 | protein folding in endoplasmic reticulum | "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw] | 5 | 4.814094e-04 | 0 |
| GO:BP | GO:2000573 | positive regulation of DNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 8 | 4.821751e-04 | 0 |
| GO:BP | GO:0071705 | nitrogen compound transport | "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] | 51 | 4.881560e-04 | 0 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 34 | 5.764701e-04 | 0 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 20 | 6.909132e-04 | 0 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 9 | 7.086033e-04 | 0 |
| GO:BP | GO:0170033 | L-amino acid metabolic process | "The chemical reactions and pathways involving an L-amino acid." [GOC:edw] | 13 | 7.529349e-04 | 0 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 52 | 7.839949e-04 | 0 |
| GO:BP | GO:1904356 | regulation of telomere maintenance via telomere lengthening | "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 8 | 8.828639e-04 | 0 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 112 | 8.922285e-04 | 0 |
| GO:BP | GO:0061615 | glycolytic process through fructose-6-phosphate | "The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479] | 6 | 8.959204e-04 | 0 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 9 | 8.969091e-04 | 0 |
| GO:BP | GO:0008652 | amino acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732] | 9 | 1.127146e-03 | 0 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [GOC:ai] | 18 | 1.204836e-03 | 0 |
| GO:BP | GO:1901605 | alpha-amino acid metabolic process | "The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie] | 14 | 1.254444e-03 | 0 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 116 | 1.495989e-03 | 0 |
| GO:BP | GO:0006007 | glucose catabolic process | "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] | 6 | 1.500528e-03 | 0 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 28 | 1.627644e-03 | 0 |
| GO:BP | GO:0006164 | purine nucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 13 | 2.299055e-03 | 0 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 25 | 2.330327e-03 | 0 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 12 | 2.512611e-03 | 0 |
| GO:BP | GO:0044282 | small molecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw] | 18 | 2.568154e-03 | 0 |
| GO:BP | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] | 11 | 2.633288e-03 | 0 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 30 | 2.972366e-03 | 0 |
| GO:BP | GO:0051156 | glucose 6-phosphate metabolic process | "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] | 6 | 2.999634e-03 | 0 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 24 | 3.142935e-03 | 0 |
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 29 | 3.153286e-03 | 0 |
| GO:BP | GO:0009060 | aerobic respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] | 13 | 3.243209e-03 | 0 |
| GO:BP | GO:0019320 | hexose catabolic process | "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] | 7 | 3.480239e-03 | 0 |
| GO:BP | GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 3.563720e-03 | 0 |
| GO:BP | GO:0009145 | purine nucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 10 | 3.863720e-03 | 0 |
| GO:BP | GO:0071456 | cellular response to hypoxia | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] | 11 | 4.034620e-03 | 0 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 24 | 4.135458e-03 | 0 |
| GO:BP | GO:0010821 | regulation of mitochondrion organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] | 10 | 4.185478e-03 | 0 |
| GO:BP | GO:1901137 | carbohydrate derivative biosynthetic process | "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie] | 23 | 4.217824e-03 | 0 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 44 | 4.520253e-03 | 0 |
| GO:BP | GO:0046364 | monosaccharide biosynthetic process | "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] | 9 | 4.699975e-03 | 0 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 24 | 4.732752e-03 | 0 |
| GO:BP | GO:0051345 | positive regulation of hydrolase activity | "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] | 13 | 4.769002e-03 | 0 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 47 | 5.707540e-03 | 0 |
| GO:BP | GO:0170039 | proteinogenic amino acid metabolic process | "The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew] | 12 | 5.944246e-03 | 0 |
| GO:BP | GO:0046365 | monosaccharide catabolic process | "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] | 7 | 6.222587e-03 | 0 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 29 | 6.330921e-03 | 0 |
| GO:BP | GO:0036294 | cellular response to decreased oxygen levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] | 11 | 6.463182e-03 | 0 |
| GO:BP | GO:1900182 | positive regulation of protein localization to nucleus | "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 9 | 6.745171e-03 | 0 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 39 | 6.800639e-03 | 0 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 40 | 8.574248e-03 | 0 |
| GO:BP | GO:0098761 | cellular response to interleukin-7 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah] | 5 | 8.679082e-03 | 0 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] | 13 | 8.905277e-03 | 0 |
| GO:BP | GO:0170034 | L-amino acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of L-amino acids, the L-enantiomers of amino acids." [GOC:edw] | 7 | 9.299685e-03 | 0 |
| GO:BP | GO:0043648 | dicarboxylic acid metabolic process | "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] | 9 | 9.513040e-03 | 0 |
| GO:BP | GO:0051049 | regulation of transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 42 | 9.936043e-03 | 0 |
| GO:BP | GO:0098760 | response to interleukin-7 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah] | 5 | 1.127479e-02 | 0 |
| GO:BP | GO:1902600 | proton transmembrane transport | "The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] | 12 | 1.166886e-02 | 0 |
| GO:BP | GO:0008037 | cell recognition | "The process in which a cell in an organism interprets its surroundings." [GOC:go_curators] | 11 | 1.211832e-02 | 0 |
| GO:BP | GO:0006754 | ATP biosynthetic process | "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732] | 9 | 1.218220e-02 | 0 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 12 | 1.231411e-02 | 0 |
| GO:BP | GO:0006520 | amino acid metabolic process | "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732] | 15 | 1.252141e-02 | 0 |
| GO:BP | GO:0170038 | proteinogenic amino acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew] | 7 | 1.355048e-02 | 0 |
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 19 | 1.407263e-02 | 0 |
| GO:BP | GO:0009306 | protein secretion | "The controlled release of proteins from a cell." [GOC:ai] | 17 | 1.454525e-02 | 0 |
| GO:BP | GO:0044093 | positive regulation of molecular function | "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 28 | 1.546259e-02 | 0 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 9 | 1.546905e-02 | 0 |
| GO:BP | GO:0035592 | establishment of protein localization to extracellular region | "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF] | 17 | 1.613020e-02 | 0 |
| GO:BP | GO:0030043 | actin filament fragmentation | "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins." [GOC:mah, ISBN:0815316194] | 3 | 1.686135e-02 | 0 |
| GO:BP | GO:0071453 | cellular response to oxygen levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah] | 11 | 1.727380e-02 | 0 |
| GO:BP | GO:0040011 | locomotion | "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] | 35 | 1.741271e-02 | 0 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] | 44 | 1.744470e-02 | 0 |
| GO:BP | GO:0071692 | protein localization to extracellular region | "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah] | 17 | 1.977241e-02 | 0 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 47 | 2.255912e-02 | 0 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 15 | 2.257704e-02 | 0 |
| GO:BP | GO:0048193 | Golgi vesicle transport | "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] | 15 | 2.257704e-02 | 0 |
| GO:BP | GO:0006094 | gluconeogenesis | "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] | 8 | 2.309941e-02 | 0 |
| GO:BP | GO:0006739 | NADP metabolic process | "The chemical reactions and pathways involving nicotinamide adenine dinucleotide phosphate (NADP+), a coenzyme that interconverts with its reduced form, NADPH, in many redox and biosynthetic reactions." [GOC:mah] | 6 | 2.502628e-02 | 0 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 11 | 2.561718e-02 | 0 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 9 | 2.620770e-02 | 0 |
| GO:BP | GO:0062197 | cellular response to chemical stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] | 15 | 2.725378e-02 | 0 |
| GO:BP | GO:0040012 | regulation of locomotion | "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems] | 31 | 2.728318e-02 | 0 |
| GO:BP | GO:0045333 | cellular respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732] | 13 | 2.752011e-02 | 0 |
| GO:BP | GO:0019319 | hexose biosynthetic process | "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] | 8 | 2.997486e-02 | 0 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 11 | 3.354253e-02 | 0 |
| GO:BP | GO:0034599 | cellular response to oxidative stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] | 13 | 3.419500e-02 | 0 |
| GO:BP | GO:0170041 | non-proteinogenic amino acid metabolic process | "The chemical reactions and pathways involving non-proteingenic amino acids." [GOC:ew] | 7 | 3.695032e-02 | 0 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 28 | 3.762727e-02 | 0 |
| GO:BP | GO:0090666 | scaRNA localization to Cajal body | "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 3 | 4.176111e-02 | 0 |
| GO:BP | GO:0042026 | protein refolding | "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] | 5 | 4.205700e-02 | 0 |
| GO:BP | GO:1904951 | positive regulation of establishment of protein localization | "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] | 15 | 4.215445e-02 | 0 |
| GO:BP | GO:0016192 | vesicle-mediated transport | "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] | 40 | 4.328516e-02 | 0 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 30 | 4.356186e-02 | 0 |
| GO:BP | GO:0009896 | positive regulation of catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 20 | 4.482702e-02 | 0 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 8 | 4.523974e-02 | 0 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4290 | Metabolic reprogramming in colon cancer | Metabolic reprogramming in colon cancer | 16 | 3.773952e-13 | 0 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 42 | 5.372799e-12 | 0 |
| WP | WP:WP4018 | Clear cell renal cell carcinoma pathways | Clear cell renal cell carcinoma pathways | 19 | 5.209769e-11 | 0 |
| WP | WP:WP4628 | Aerobic glycolysis augmented | Aerobic glycolysis augmented | 9 | 5.409464e-10 | 0 |
| WP | WP:WP534 | Glycolysis and gluconeogenesis | Glycolysis and gluconeogenesis | 14 | 5.870991e-10 | 0 |
| WP | WP:WP5355 | Metabolic epileptic disorders | Metabolic epileptic disorders | 17 | 2.089892e-08 | 0 |
| WP | WP:WP2359 | Parkin ubiquitin proteasomal system pathway | Parkin ubiquitin proteasomal system pathway | 15 | 4.385748e-08 | 0 |
| WP | WP:WP5049 | Glycolysis in senescence | Glycolysis in senescence | 7 | 4.080102e-07 | 0 |
| WP | WP:WP1946 | Cori cycle | Cori cycle | 8 | 6.668720e-07 | 0 |
| WP | WP:WP183 | Proteasome degradation | Proteasome degradation | 13 | 8.055923e-07 | 0 |
| WP | WP:WP5312 | Metabolic pathways of fibroblasts | Metabolic pathways of fibroblasts | 9 | 1.388052e-05 | 0 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 22 | 1.559270e-04 | 0 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 22 | 2.154666e-04 | 0 |
| WP | WP:WP3925 | Amino acid metabolism | Amino acid metabolism | 12 | 6.419409e-04 | 0 |
| WP | WP:WP4949 | 16p11 2 proximal deletion syndrome | 16p11 2 proximal deletion syndrome | 10 | 4.419134e-03 | 0 |
| WP | WP:WP5211 | Glucose metabolism in triple negative breast cancer cells | Glucose metabolism in triple negative breast cancer cells | 4 | 5.550893e-03 | 0 |
| WP | WP:WP5220 | Metabolic reprogramming in pancreatic cancer | Metabolic reprogramming in pancreatic cancer | 7 | 1.694956e-02 | 0 |
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 11 | 2.692169e-02 | 0 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 52 | 4.598929e-13 | 0 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 55 | 5.406501e-09 | 0 |
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 25 | 2.306875e-06 | 0 |
| MIRNA | MIRNA:hsa-mir-222-3p | hsa-mir-222-3p | hsa-mir-222-3p | 24 | 5.588740e-06 | 0 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 52 | 1.540603e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-324-5p | hsa-mir-324-5p | hsa-mir-324-5p | 35 | 3.180101e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-331-3p | hsa-mir-331-3p | hsa-mir-331-3p | 45 | 6.671522e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-3175 | hsa-mir-3175 | hsa-mir-3175 | 57 | 9.053443e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-1301-3p | hsa-mir-1301-3p | hsa-mir-1301-3p | 15 | 2.662408e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 53 | 5.700995e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-17-3p | hsa-mir-17-3p | hsa-mir-17-3p | 13 | 6.012754e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 32 | 1.035355e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-324-3p | hsa-mir-324-3p | hsa-mir-324-3p | 49 | 1.224308e-03 | 0 |
| MIRNA | MIRNA:hsa-let-7b-5p | hsa-let-7b-5p | hsa-let-7b-5p | 39 | 3.346816e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-939 | hsa-mir-939 | hsa-mir-939 | 47 | 4.768233e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-1-3p | hsa-mir-1-3p | hsa-mir-1-3p | 32 | 6.237533e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-149-5p | hsa-mir-149-5p | hsa-mir-149-5p | 19 | 6.642208e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-335 | hsa-mir-335 | hsa-mir-335 | 36 | 7.013757e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-4290 | hsa-mir-4290 | hsa-mir-4290 | 31 | 1.282426e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3150a-3p | hsa-mir-3150a-3p | hsa-mir-3150a-3p | 48 | 1.396867e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-133a-3p | hsa-mir-133a-3p | hsa-mir-133a-3p | 10 | 1.553877e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-186-5p | hsa-mir-186-5p | hsa-mir-186-5p | 27 | 1.659752e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-15b-5p | hsa-mir-15b-5p | hsa-mir-15b-5p | 27 | 2.407416e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4267 | hsa-mir-4267 | hsa-mir-4267 | 41 | 2.415686e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-484 | hsa-mir-484 | hsa-mir-484 | 54 | 2.528700e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-3157-3p | hsa-mir-3157-3p | hsa-mir-3157-3p | 23 | 2.557305e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-23b-3p | hsa-mir-23b-3p | hsa-mir-23b-3p | 16 | 3.025393e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-30a-5p | hsa-mir-30a-5p | hsa-mir-30a-5p | 26 | 3.232624e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-877-5p | hsa-mir-877-5p | hsa-mir-877-5p | 13 | 3.281929e-02 | 0 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:01230 | Biosynthesis of amino acids | Biosynthesis of amino acids | 18 | 1.102434e-12 | 0 |
| KEGG | KEGG:01200 | Carbon metabolism | Carbon metabolism | 20 | 3.248860e-11 | 0 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 28 | 1.910988e-10 | 0 |
| KEGG | KEGG:05020 | Prion disease | Prion disease | 26 | 1.132441e-08 | 0 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 33 | 1.471910e-07 | 0 |
| KEGG | KEGG:01100 | Metabolic pathways | Metabolic pathways | 67 | 1.607623e-07 | 0 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 29 | 2.341055e-07 | 0 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis | 28 | 3.206835e-07 | 0 |
| KEGG | KEGG:00010 | Glycolysis / Gluconeogenesis | Glycolysis / Gluconeogenesis | 12 | 1.484170e-06 | 0 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 18 | 1.799588e-06 | 0 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 23 | 1.415099e-05 | 0 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | Spinocerebellar ataxia | 15 | 3.219326e-05 | 0 |
| KEGG | KEGG:03050 | Proteasome | Proteasome | 9 | 4.525648e-05 | 0 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 19 | 1.561592e-04 | 0 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | HIF-1 signaling pathway | 12 | 3.523528e-04 | 0 |
| KEGG | KEGG:00270 | Cysteine and methionine metabolism | Cysteine and methionine metabolism | 8 | 9.793746e-04 | 0 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | Central carbon metabolism in cancer | 9 | 1.711171e-03 | 0 |
| KEGG | KEGG:00030 | Pentose phosphate pathway | Pentose phosphate pathway | 6 | 4.292320e-03 | 0 |
| KEGG | KEGG:00480 | Glutathione metabolism | Glutathione metabolism | 7 | 1.810636e-02 | 0 |
| KEGG | KEGG:00620 | Pyruvate metabolism | Pyruvate metabolism | 6 | 4.702408e-02 | 0 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M02090 | Factor: E2F-4; motif: GCGGGAAANA | Factor: E2F-4; motif: GCGGGAAANA | 223 | 2.466507e-11 | 0 |
| TF | TF:M11529_1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | 249 | 2.591285e-11 | 0 |
| TF | TF:M00803_1 | Factor: E2F; motif: GGCGSG; match class: 1 | Factor: E2F; motif: GGCGSG; match class: 1 | 201 | 1.142367e-10 | 0 |
| TF | TF:M07395 | Factor: Sp1; motif: NGGGGCGGGGN | Factor: Sp1; motif: NGGGGCGGGGN | 205 | 4.941023e-10 | 0 |
| TF | TF:M00716_1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | 243 | 6.842122e-10 | 0 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 250 | 7.624664e-10 | 0 |
| TF | TF:M04869 | Factor: Egr-1; motif: GCGCATGCG | Factor: Egr-1; motif: GCGCATGCG | 211 | 1.234055e-09 | 0 |
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 233 | 1.320368e-09 | 0 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 250 | 3.404759e-09 | 0 |
| TF | TF:M00196 | Factor: Sp1; motif: NGGGGGCGGGGYN | Factor: Sp1; motif: NGGGGGCGGGGYN | 198 | 3.499200e-09 | 0 |
| TF | TF:M11601_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 208 | 3.609540e-09 | 0 |
| TF | TF:M02090_1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | 143 | 1.120029e-08 | 0 |
| TF | TF:M12173 | Factor: GKLF; motif: NNCCMCRCCCN | Factor: GKLF; motif: NNCCMCRCCCN | 193 | 1.443734e-08 | 0 |
| TF | TF:M03920 | Factor: SP1; motif: RCCMCRCCCMC | Factor: SP1; motif: RCCMCRCCCMC | 155 | 3.278247e-08 | 0 |
| TF | TF:M11531 | Factor: E2F-2; motif: GCGCGCGCGYW | Factor: E2F-2; motif: GCGCGCGCGYW | 231 | 3.560630e-08 | 0 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 238 | 4.239505e-08 | 0 |
| TF | TF:M04869_1 | Factor: Egr-1; motif: GCGCATGCG; match class: 1 | Factor: Egr-1; motif: GCGCATGCG; match class: 1 | 195 | 4.544457e-08 | 0 |
| TF | TF:M11880_1 | Factor: pax-6; motif: NYACGCWTSANYGMNCN; match class: 1 | Factor: pax-6; motif: NYACGCWTSANYGMNCN; match class: 1 | 150 | 5.982265e-08 | 0 |
| TF | TF:M00931 | Factor: Sp1; motif: GGGGCGGGGC | Factor: Sp1; motif: GGGGCGGGGC | 195 | 8.272136e-08 | 0 |
| TF | TF:M12666 | Factor: SP1; motif: GGCCCCGCCCCCN | Factor: SP1; motif: GGCCCCGCCCCCN | 173 | 1.297162e-07 | 0 |
| TF | TF:M01783 | Factor: SP2; motif: GGGCGGGAC | Factor: SP2; motif: GGGCGGGAC | 179 | 1.391513e-07 | 0 |
| TF | TF:M07206_1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | 201 | 2.218526e-07 | 0 |
| TF | TF:M08225_1 | Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 | Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 | 162 | 3.691860e-07 | 0 |
| TF | TF:M11882_1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | 207 | 4.049853e-07 | 0 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 256 | 4.809464e-07 | 0 |
| TF | TF:M10438 | Factor: ZF5; motif: GGSGCGCGS | Factor: ZF5; motif: GGSGCGCGS | 257 | 5.232761e-07 | 0 |
| TF | TF:M11603_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 227 | 5.917037e-07 | 0 |
| TF | TF:M12597_1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | 187 | 7.387662e-07 | 0 |
| TF | TF:M03807 | Factor: SP2; motif: GNNGGGGGCGGGGSN | Factor: SP2; motif: GNNGGGGGCGGGGSN | 167 | 1.114786e-06 | 0 |
| TF | TF:M04515_1 | Factor: E2F-1; motif: WWTGGCGCCAAA; match class: 1 | Factor: E2F-1; motif: WWTGGCGCCAAA; match class: 1 | 215 | 1.153370e-06 | 0 |
| TF | TF:M00933 | Factor: Sp1; motif: CCCCGCCCCN | Factor: Sp1; motif: CCCCGCCCCN | 184 | 1.402691e-06 | 0 |
| TF | TF:M11601 | Factor: TCF-1; motif: ACATCGRGRCGCTGW | Factor: TCF-1; motif: ACATCGRGRCGCTGW | 243 | 1.689664e-06 | 0 |
| TF | TF:M09636_1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | 236 | 1.901233e-06 | 0 |
| TF | TF:M00932 | Factor: Sp1; motif: NNGGGGCGGGGNN | Factor: Sp1; motif: NNGGGGCGGGGNN | 193 | 1.979601e-06 | 0 |
| TF | TF:M01240_1 | Factor: BEN; motif: CAGCGRNV; match class: 1 | Factor: BEN; motif: CAGCGRNV; match class: 1 | 226 | 2.406987e-06 | 0 |
| TF | TF:M13135 | Factor: SP4; motif: GGCCCCGCCCCCN | Factor: SP4; motif: GGCCCCGCCCCCN | 124 | 2.494745e-06 | 0 |
| TF | TF:M12186 | Factor: BTEB4; motif: NCCACGCCCM | Factor: BTEB4; motif: NCCACGCCCM | 175 | 2.508001e-06 | 0 |
| TF | TF:M00333_1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | 217 | 2.578499e-06 | 0 |
| TF | TF:M01588 | Factor: GKLF; motif: GCCMCRCCCNNN | Factor: GKLF; motif: GCCMCRCCCNNN | 172 | 3.185135e-06 | 0 |
| TF | TF:M09765 | Factor: SP1; motif: NRGKGGGCGGGGCN | Factor: SP1; motif: NRGKGGGCGGGGCN | 152 | 3.384611e-06 | 0 |
| TF | TF:M11530_1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | 228 | 3.630472e-06 | 0 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 192 | 3.797281e-06 | 0 |
| TF | TF:M08525_1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | 247 | 3.870509e-06 | 0 |
| TF | TF:M00333 | Factor: ZF5; motif: NRNGNGCGCGCWN | Factor: ZF5; motif: NRNGNGCGCGCWN | 245 | 4.410714e-06 | 0 |
| TF | TF:M07206 | Factor: E2F-1; motif: NGGGCGGGARV | Factor: E2F-1; motif: NGGGCGGGARV | 240 | 4.543569e-06 | 0 |
| TF | TF:M09892_1 | Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 | Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 | 175 | 6.386062e-06 | 0 |
| TF | TF:M10435 | Factor: Sp2; motif: GGGGCGGGG | Factor: Sp2; motif: GGGGCGGGG | 154 | 8.757342e-06 | 0 |
| TF | TF:M03567 | Factor: Sp2; motif: NYSGCCCCGCCCCCY | Factor: Sp2; motif: NYSGCCCCGCCCCCY | 154 | 9.699423e-06 | 0 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 250 | 1.020447e-05 | 0 |
| TF | TF:M11531_1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | 214 | 1.465098e-05 | 0 |
| TF | TF:M07250 | Factor: E2F-1; motif: NNNSSCGCSAANN | Factor: E2F-1; motif: NNNSSCGCSAANN | 194 | 1.526863e-05 | 0 |
| TF | TF:M10530 | Factor: sp4; motif: NNNGCYCCGCCCCCY | Factor: sp4; motif: NNNGCYCCGCCCCCY | 160 | 1.901534e-05 | 0 |
| TF | TF:M07615 | Factor: Sp3; motif: GGGGCGGGGSNN | Factor: Sp3; motif: GGGGCGGGGSNN | 140 | 1.978708e-05 | 0 |
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 245 | 2.049869e-05 | 0 |
| TF | TF:M04515 | Factor: E2F-1; motif: WWTGGCGCCAAA | Factor: E2F-1; motif: WWTGGCGCCAAA | 225 | 2.105601e-05 | 0 |
| TF | TF:M09970 | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN | 153 | 2.198927e-05 | 0 |
| TF | TF:M11435 | Factor: Elk-1; motif: NNCCGGAAGTN | Factor: Elk-1; motif: NNCCGGAAGTN | 205 | 2.401090e-05 | 0 |
| TF | TF:M11882 | Factor: pax-6; motif: NYACGCNYSANYGMNCN | Factor: pax-6; motif: NYACGCNYSANYGMNCN | 247 | 2.751225e-05 | 0 |
| TF | TF:M08207_1 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 | 247 | 2.870126e-05 | 0 |
| TF | TF:M09892 | Factor: E2F-1; motif: NNNNGGCGGGAARN | Factor: E2F-1; motif: NNNNGGCGGGAARN | 227 | 2.877930e-05 | 0 |
| TF | TF:M09723 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS | 184 | 3.166441e-05 | 0 |
| TF | TF:M07063 | Factor: Sp1; motif: GGGGCGGGGC | Factor: Sp1; motif: GGGGCGGGGC | 131 | 3.682163e-05 | 0 |
| TF | TF:M04691 | Factor: Kaiso; motif: TCTCGCGAG | Factor: Kaiso; motif: TCTCGCGAG | 243 | 3.759743e-05 | 0 |
| TF | TF:M12597 | Factor: E2F1; motif: GSGCGGGAAN | Factor: E2F1; motif: GSGCGGGAAN | 232 | 3.804604e-05 | 0 |
| TF | TF:M08875 | Factor: E2F; motif: NNTTTCGCGCN | Factor: E2F; motif: NNTTTCGCGCN | 130 | 3.892111e-05 | 0 |
| TF | TF:M04516 | Factor: E2F-1; motif: TTTGGCGCCAAA | Factor: E2F-1; motif: TTTGGCGCCAAA | 201 | 4.023937e-05 | 0 |
| TF | TF:M09826 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC | 204 | 4.430716e-05 | 0 |
| TF | TF:M10072 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | 190 | 4.885142e-05 | 0 |
| TF | TF:M07409 | Factor: BTEB2; motif: GCCCCRCCCH | Factor: BTEB2; motif: GCCCCRCCCH | 114 | 5.293172e-05 | 0 |
| TF | TF:M11396 | Factor: Erg; motif: NACCGGAARTN | Factor: Erg; motif: NACCGGAARTN | 192 | 5.820098e-05 | 0 |
| TF | TF:M00986_1 | Factor: Churchill; motif: CGGGNN; match class: 1 | Factor: Churchill; motif: CGGGNN; match class: 1 | 188 | 5.987067e-05 | 0 |
| TF | TF:M07395_1 | Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 | Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 | 132 | 6.083156e-05 | 0 |
| TF | TF:M04710_1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | 201 | 6.154525e-05 | 0 |
| TF | TF:M04106 | Factor: RUNX2; motif: NRACCGCAAACCGCAN | Factor: RUNX2; motif: NRACCGCAAACCGCAN | 228 | 8.016099e-05 | 0 |
| TF | TF:M04823_1 | Factor: E2F-4; motif: NNTTCCCGCCNN; match class: 1 | Factor: E2F-4; motif: NNTTCCCGCCNN; match class: 1 | 153 | 8.204012e-05 | 0 |
| TF | TF:M00428 | Factor: E2F-1; motif: NKTSSCGC | Factor: E2F-1; motif: NKTSSCGC | 168 | 9.619413e-05 | 0 |
| TF | TF:M10071 | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG | 162 | 9.914364e-05 | 0 |
| TF | TF:M04106_1 | Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 | Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 | 160 | 1.028674e-04 | 0 |
| TF | TF:M04516_1 | Factor: E2F-1; motif: TTTGGCGCCAAA; match class: 1 | Factor: E2F-1; motif: TTTGGCGCCAAA; match class: 1 | 185 | 1.102324e-04 | 0 |
| TF | TF:M07084 | Factor: E2F-4; motif: NGGCGGGAARN | Factor: E2F-4; motif: NGGCGGGAARN | 193 | 1.116926e-04 | 0 |
| TF | TF:M08874 | Factor: E2F1; motif: NNNNNGCGSSAAAN | Factor: E2F1; motif: NNNNNGCGSSAAAN | 143 | 1.143263e-04 | 0 |
| TF | TF:M11018_1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | 250 | 1.371090e-04 | 0 |
| TF | TF:M02089 | Factor: E2F-3; motif: GGCGGGN | Factor: E2F-3; motif: GGCGGGN | 221 | 1.534684e-04 | 0 |
| TF | TF:M07277 | Factor: BTEB2; motif: RGGGNGKGGN | Factor: BTEB2; motif: RGGGNGKGGN | 161 | 1.726673e-04 | 0 |
| TF | TF:M08266_1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | 167 | 1.794280e-04 | 0 |
| TF | TF:M12151 | Factor: Sp1; motif: NWRGCCMCGCCCMCN | Factor: Sp1; motif: NWRGCCMCGCCCMCN | 137 | 1.842574e-04 | 0 |
| TF | TF:M00008 | Factor: Sp1; motif: GGGGCGGGGT | Factor: Sp1; motif: GGGGCGGGGT | 182 | 1.873424e-04 | 0 |
| TF | TF:M11529 | Factor: E2F-2; motif: GCGCGCGCNCS | Factor: E2F-2; motif: GCGCGCGCNCS | 253 | 2.214959e-04 | 0 |
| TF | TF:M13366 | Factor: ZBED4; motif: CCCGCYCCGC | Factor: ZBED4; motif: CCCGCYCCGC | 149 | 2.227764e-04 | 0 |
| TF | TF:M11530 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | 236 | 2.349367e-04 | 0 |
| TF | TF:M13129 | Factor: RERE; motif: CNGCNSCNNGSRCRGSGSS | Factor: RERE; motif: CNGCNSCNNGSRCRGSGSS | 182 | 2.358885e-04 | 0 |
| TF | TF:M13124_1 | Factor: ZNF670; motif: SNGGGCRGRG; match class: 1 | Factor: ZNF670; motif: SNGGGCRGRG; match class: 1 | 156 | 2.685374e-04 | 0 |
| TF | TF:M04950 | Factor: Egr-1; motif: NGCGTGCGY | Factor: Egr-1; motif: NGCGTGCGY | 192 | 3.052632e-04 | 0 |
| TF | TF:M09723_1 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 | 124 | 3.106198e-04 | 0 |
| TF | TF:M07380_1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | 153 | 3.167461e-04 | 0 |
| TF | TF:M08523_1 | Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN; match class: 1 | Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN; match class: 1 | 144 | 3.588597e-04 | 0 |
| TF | TF:M07250_1 | Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 | Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 | 116 | 4.018396e-04 | 0 |
| TF | TF:M11883 | Factor: pax-6; motif: NYACGCNTSRNYGCNYN | Factor: pax-6; motif: NYACGCNTSRNYGCNYN | 222 | 4.140307e-04 | 0 |
| TF | TF:M12152 | Factor: Sp1; motif: NWRGCCACGCCCMCN | Factor: Sp1; motif: NWRGCCACGCCCMCN | 143 | 4.287135e-04 | 0 |
| TF | TF:M08226_1 | Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 | Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 | 117 | 4.499096e-04 | 0 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 102 | 4.629222e-04 | 0 |
| TF | TF:M02065 | Factor: ER81; motif: RCCGGAARYN | Factor: ER81; motif: RCCGGAARYN | 214 | 4.877911e-04 | 0 |
| TF | TF:M01660 | Factor: GABP-alpha; motif: CTTCCK | Factor: GABP-alpha; motif: CTTCCK | 193 | 5.479206e-04 | 0 |
| TF | TF:M13124 | Factor: ZNF670; motif: SNGGGCRGRG | Factor: ZNF670; motif: SNGGGCRGRG | 214 | 5.708921e-04 | 0 |
| TF | TF:M04710 | Factor: CHD2; motif: TCTCGCGAG | Factor: CHD2; motif: TCTCGCGAG | 229 | 5.713690e-04 | 0 |
| TF | TF:M00736 | Factor: E2F-1:DP-1; motif: TTTCSCGC | Factor: E2F-1:DP-1; motif: TTTCSCGC | 184 | 6.095644e-04 | 0 |
| TF | TF:M09641 | Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN | Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN | 78 | 6.568739e-04 | 0 |
| TF | TF:M07084_1 | Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 | Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 | 114 | 7.160425e-04 | 0 |
| TF | TF:M08525 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM | 259 | 8.426612e-04 | 0 |
| TF | TF:M12351_1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | 153 | 8.456134e-04 | 0 |
| TF | TF:M12186_1 | Factor: BTEB4; motif: NCCACGCCCM; match class: 1 | Factor: BTEB4; motif: NCCACGCCCM; match class: 1 | 90 | 9.414267e-04 | 0 |
| TF | TF:M09894 | Factor: E2F-4; motif: SNGGGCGGGAANN | Factor: E2F-4; motif: SNGGGCGGGAANN | 251 | 9.773684e-04 | 0 |
| TF | TF:M00986 | Factor: Churchill; motif: CGGGNN | Factor: Churchill; motif: CGGGNN | 230 | 1.049821e-03 | 0 |
| TF | TF:M08266 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG | 231 | 1.120930e-03 | 0 |
| TF | TF:M13147 | Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN | Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN | 192 | 1.137324e-03 | 0 |
| TF | TF:M07226 | Factor: SP1; motif: NCCCCKCCCCC | Factor: SP1; motif: NCCCCKCCCCC | 155 | 1.151339e-03 | 0 |
| TF | TF:M04826 | Factor: p300; motif: ACNTCCG | Factor: p300; motif: ACNTCCG | 264 | 1.237545e-03 | 0 |
| TF | TF:M09636 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG | 251 | 1.309725e-03 | 0 |
| TF | TF:M04823 | Factor: E2F-4; motif: NNTTCCCGCCNN | Factor: E2F-4; motif: NNTTCCCGCCNN | 213 | 1.402093e-03 | 0 |
| TF | TF:M09893 | Factor: E2F-3; motif: NNGGCGGGAAA | Factor: E2F-3; motif: NNGGCGGGAAA | 122 | 1.470548e-03 | 0 |
| TF | TF:M07039_1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | 223 | 1.664537e-03 | 0 |
| TF | TF:M12590 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN | 191 | 1.667267e-03 | 0 |
| TF | TF:M00113 | Factor: CREB; motif: NNGNTGACGTNN | Factor: CREB; motif: NNGNTGACGTNN | 105 | 1.830649e-03 | 0 |
| TF | TF:M11535 | Factor: E2F-4; motif: TTTTGGCGCCAWWN | Factor: E2F-4; motif: TTTTGGCGCCAWWN | 189 | 1.864430e-03 | 0 |
| TF | TF:M00938 | Factor: E2F-1; motif: TTGGCGCGRAANNGNM | Factor: E2F-1; motif: TTGGCGCGRAANNGNM | 140 | 1.961980e-03 | 0 |
| TF | TF:M11603 | Factor: TCF-1; motif: ACATCGRGRCGCTGW | Factor: TCF-1; motif: ACATCGRGRCGCTGW | 251 | 2.034321e-03 | 0 |
| TF | TF:M12160 | Factor: KLF15; motif: RCCMCRCCCMCN | Factor: KLF15; motif: RCCMCRCCCMCN | 212 | 2.049295e-03 | 0 |
| TF | TF:M00738 | Factor: E2F-4:DP-1; motif: TTTSGCGC | Factor: E2F-4:DP-1; motif: TTTSGCGC | 175 | 2.063118e-03 | 0 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 256 | 2.073613e-03 | 0 |
| TF | TF:M11058 | Factor: Hey1; motif: NGCRCGYGYN | Factor: Hey1; motif: NGCRCGYGYN | 200 | 2.173778e-03 | 0 |
| TF | TF:M13031 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 187 | 2.209770e-03 | 0 |
| TF | TF:M12599 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN | 259 | 2.247854e-03 | 0 |
| TF | TF:M01857 | Factor: AP-2alpha; motif: NGCCYSNNGSN | Factor: AP-2alpha; motif: NGCCYSNNGSN | 166 | 2.522860e-03 | 0 |
| TF | TF:M02071 | Factor: ETV7; motif: NCCGGAANNN | Factor: ETV7; motif: NCCGGAANNN | 178 | 2.936041e-03 | 0 |
| TF | TF:M08377_1 | Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 | Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 | 105 | 2.971994e-03 | 0 |
| TF | TF:M07052 | Factor: NRF-1; motif: GCGCMTGCGCN | Factor: NRF-1; motif: GCGCMTGCGCN | 56 | 3.339643e-03 | 0 |
| TF | TF:M09967 | Factor: AP-2rep; motif: NGGGGCGGGGC | Factor: AP-2rep; motif: NGGGGCGGGGC | 89 | 3.852919e-03 | 0 |
| TF | TF:M09593 | Factor: Bach1; motif: TGCTGAGTCANNS | Factor: Bach1; motif: TGCTGAGTCANNS | 23 | 4.040753e-03 | 0 |
| TF | TF:M13149_1 | Factor: ZNF219; motif: SNNCAGCACCNNGGNCAGCGSC; match class: 1 | Factor: ZNF219; motif: SNNCAGCACCNNGGNCAGCGSC; match class: 1 | 129 | 4.082266e-03 | 0 |
| TF | TF:M11400 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 175 | 4.139349e-03 | 0 |
| TF | TF:M00695_1 | Factor: ETF; motif: GVGGMGG; match class: 1 | Factor: ETF; motif: GVGGMGG; match class: 1 | 135 | 4.146793e-03 | 0 |
| TF | TF:M08205_1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | 182 | 4.650231e-03 | 0 |
| TF | TF:M01240 | Factor: BEN; motif: CAGCGRNV | Factor: BEN; motif: CAGCGRNV | 252 | 4.693903e-03 | 0 |
| TF | TF:M03977 | Factor: ETS1; motif: ACCGGAARYN | Factor: ETS1; motif: ACCGGAARYN | 182 | 6.031662e-03 | 0 |
| TF | TF:M11058_1 | Factor: Hey1; motif: NGCRCGYGYN; match class: 1 | Factor: Hey1; motif: NGCRCGYGYN; match class: 1 | 174 | 6.099941e-03 | 0 |
| TF | TF:M11018 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | 256 | 6.487627e-03 | 0 |
| TF | TF:M10072_1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | 123 | 6.723539e-03 | 0 |
| TF | TF:M00981 | Factor: CREB,; motif: NTGACGTNA | Factor: CREB,; motif: NTGACGTNA | 152 | 6.803370e-03 | 0 |
| TF | TF:M00025 | Factor: Elk-1; motif: NNNNCCGGAARTNN | Factor: Elk-1; motif: NNNNCCGGAARTNN | 175 | 7.656146e-03 | 0 |
| TF | TF:M08523 | Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN | Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN | 203 | 7.798366e-03 | 0 |
| TF | TF:M08441 | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG | 250 | 8.047672e-03 | 0 |
| TF | TF:M11881_1 | Factor: pax-6; motif: NYACGCNTSANYGCNYN; match class: 1 | Factor: pax-6; motif: NYACGCNTSANYGCNYN; match class: 1 | 135 | 8.623614e-03 | 0 |
| TF | TF:M08377 | Factor: meis1:Elf-1; motif: NTGCCGGAAGTN | Factor: meis1:Elf-1; motif: NTGCCGGAAGTN | 191 | 8.908988e-03 | 0 |
| TF | TF:M08205 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | 230 | 9.657096e-03 | 0 |
| TF | TF:M08206 | Factor: E2F-3:Prrxl1; motif: SGCGCTAATTNN | Factor: E2F-3:Prrxl1; motif: SGCGCTAATTNN | 197 | 9.909301e-03 | 0 |
| TF | TF:M09973_1 | Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 | Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 | 128 | 9.925227e-03 | 0 |
| TF | TF:M01770_1 | Factor: XBP-1; motif: WNNGMCACGTC; match class: 1 | Factor: XBP-1; motif: WNNGMCACGTC; match class: 1 | 96 | 1.036088e-02 | 0 |
| TF | TF:M12600 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | 156 | 1.053744e-02 | 0 |
| TF | TF:M12590_1 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1 | 129 | 1.069978e-02 | 0 |
| TF | TF:M08759 | Factor: c-Ets-2; motif: NCCGGAAGTG | Factor: c-Ets-2; motif: NCCGGAAGTG | 151 | 1.082831e-02 | 0 |
| TF | TF:M04918 | Factor: Egr-1; motif: ACCGCCC | Factor: Egr-1; motif: ACCGCCC | 112 | 1.152313e-02 | 0 |
| TF | TF:M07039 | Factor: ETF; motif: CCCCGCCCCYN | Factor: ETF; motif: CCCCGCCCCYN | 250 | 1.232177e-02 | 0 |
| TF | TF:M11881 | Factor: pax-6; motif: NYACGCNTSANYGCNYN | Factor: pax-6; motif: NYACGCNTSANYGCNYN | 214 | 1.244892e-02 | 0 |
| TF | TF:M12598_1 | Factor: E2F3; motif: NNRGMKGGAR; match class: 1 | Factor: E2F3; motif: NNRGMKGGAR; match class: 1 | 132 | 1.293089e-02 | 0 |
| TF | TF:M09814 | Factor: MYCN; motif: NNCCACGTGGNN | Factor: MYCN; motif: NNCCACGTGGNN | 53 | 1.364239e-02 | 0 |
| TF | TF:M09814_1 | Factor: MYCN; motif: NNCCACGTGGNN; match class: 1 | Factor: MYCN; motif: NNCCACGTGGNN; match class: 1 | 53 | 1.364239e-02 | 0 |
| TF | TF:M00932_1 | Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 | Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 | 119 | 1.367687e-02 | 0 |
| TF | TF:M09918 | Factor: Pet-1; motif: GCNGGAAGYG | Factor: Pet-1; motif: GCNGGAAGYG | 219 | 1.435921e-02 | 0 |
| TF | TF:M08568_1 | Factor: ER71:E2A; motif: CASSTGNACCGGAWRYN; match class: 1 | Factor: ER71:E2A; motif: CASSTGNACCGGAWRYN; match class: 1 | 236 | 1.460097e-02 | 0 |
| TF | TF:M12173_1 | Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 | Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 | 102 | 1.469497e-02 | 0 |
| TF | TF:M08207 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT | 256 | 1.474298e-02 | 0 |
| TF | TF:M09969 | Factor: EKLF; motif: NGGGYGKGGCNNGG | Factor: EKLF; motif: NGGGYGKGGCNNGG | 96 | 1.545082e-02 | 0 |
| TF | TF:M13031_1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | 100 | 1.597687e-02 | 0 |
| TF | TF:M08441_1 | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 | 209 | 1.647086e-02 | 0 |
| TF | TF:M02089_1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | 166 | 1.651021e-02 | 0 |
| TF | TF:M11382_1 | Factor: ESE-1; motif: NWTRCGGAWGCN; match class: 1 | Factor: ESE-1; motif: NWTRCGGAWGCN; match class: 1 | 88 | 1.702136e-02 | 0 |
| TF | TF:M09868 | Factor: ATF-3; motif: GGTSACGTGAN | Factor: ATF-3; motif: GGTSACGTGAN | 122 | 1.774593e-02 | 0 |
| TF | TF:M09826_1 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 | 142 | 1.798608e-02 | 0 |
| TF | TF:M11427 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 181 | 1.932300e-02 | 0 |
| TF | TF:M07380 | Factor: E2F-4; motif: NTTTCSCGCC | Factor: E2F-4; motif: NTTTCSCGCC | 212 | 2.053486e-02 | 0 |
| TF | TF:M09817_1 | Factor: PAX5; motif: RNGCGTGACCNN; match class: 1 | Factor: PAX5; motif: RNGCGTGACCNN; match class: 1 | 119 | 2.101132e-02 | 0 |
| TF | TF:M11883_1 | Factor: pax-6; motif: NYACGCNTSRNYGCNYN; match class: 1 | Factor: pax-6; motif: NYACGCNTSRNYGCNYN; match class: 1 | 142 | 2.185981e-02 | 0 |
| TF | TF:M00931_1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | 116 | 2.249547e-02 | 0 |
| TF | TF:M12598 | Factor: E2F3; motif: NNRGMKGGAR | Factor: E2F3; motif: NNRGMKGGAR | 205 | 2.300524e-02 | 0 |
| TF | TF:M01104 | Factor: MOVO-B; motif: GNGGGGG | Factor: MOVO-B; motif: GNGGGGG | 177 | 2.363161e-02 | 0 |
| TF | TF:M02102 | Factor: NRF-1; motif: YGCGCMTGCGC | Factor: NRF-1; motif: YGCGCMTGCGC | 52 | 2.372991e-02 | 0 |
| TF | TF:M08457_1 | Factor: ER71:SREBP-2; motif: NTSACGTGACGGAARY; match class: 1 | Factor: ER71:SREBP-2; motif: NTSACGTGACGGAARY; match class: 1 | 110 | 2.399153e-02 | 0 |
| TF | TF:M12526 | Factor: MAFK; motif: NNMTGACTCAGCMNN | Factor: MAFK; motif: NNMTGACTCAGCMNN | 20 | 2.442375e-02 | 0 |
| TF | TF:M03976 | Factor: ERG; motif: ACCGGAWATCCGGT | Factor: ERG; motif: ACCGGAWATCCGGT | 208 | 2.476749e-02 | 0 |
| TF | TF:M00025_1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | 92 | 2.479073e-02 | 0 |
| TF | TF:M00740 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | 179 | 2.484517e-02 | 0 |
| TF | TF:M00940 | Factor: E2F-1; motif: NTTTCGCGCS | Factor: E2F-1; motif: NTTTCGCGCS | 143 | 2.487389e-02 | 0 |
| TF | TF:M09896 | Factor: E2F-7; motif: GRGGCGGGAANNN | Factor: E2F-7; motif: GRGGCGGGAANNN | 173 | 2.497782e-02 | 0 |
| TF | TF:M13132 | Factor: ZNF609; motif: GNSNGGGNGCTGN | Factor: ZNF609; motif: GNSNGGGNGCTGN | 192 | 2.603899e-02 | 0 |
| TF | TF:M11052_1 | Factor: Hey2; motif: NNCACGYGNN; match class: 1 | Factor: Hey2; motif: NNCACGYGNN; match class: 1 | 166 | 2.646686e-02 | 0 |
| TF | TF:M00144_1 | Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM; match class: 1 | Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM; match class: 1 | 133 | 2.665092e-02 | 0 |
| TF | TF:M11396_1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | 100 | 2.749968e-02 | 0 |
| TF | TF:M13127 | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS | 202 | 2.990963e-02 | 0 |
| TF | TF:M12351 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC | 202 | 3.126845e-02 | 0 |
| TF | TF:M13144 | Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS | Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS | 165 | 3.198275e-02 | 0 |
| TF | TF:M11424 | Factor: Erm; motif: NNSCGGAWGYN | Factor: Erm; motif: NNSCGGAWGYN | 147 | 3.276601e-02 | 0 |
| TF | TF:M12158 | Factor: KLF15; motif: NCCMCGCCCMCN | Factor: KLF15; motif: NCCMCGCCCMCN | 179 | 3.354974e-02 | 0 |
| TF | TF:M09817 | Factor: PAX5; motif: RNGCGTGACCNN | Factor: PAX5; motif: RNGCGTGACCNN | 204 | 3.559886e-02 | 0 |
| TF | TF:M08913 | Factor: FLI-1; motif: NAYTTCCGGT | Factor: FLI-1; motif: NAYTTCCGGT | 149 | 3.684453e-02 | 0 |
| TF | TF:M00217 | Factor: USF; motif: NCACGTGN | Factor: USF; motif: NCACGTGN | 86 | 3.693052e-02 | 0 |
| TF | TF:M02102_1 | Factor: NRF-1; motif: YGCGCMTGCGC; match class: 1 | Factor: NRF-1; motif: YGCGCMTGCGC; match class: 1 | 24 | 3.713382e-02 | 0 |
| TF | TF:M07114 | Factor: c-MAF:NF-E2p45; motif: ATGACTCAGCANWTN | Factor: c-MAF:NF-E2p45; motif: ATGACTCAGCANWTN | 26 | 3.761177e-02 | 0 |
| TF | TF:M13147_1 | Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN; match class: 1 | Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN; match class: 1 | 125 | 3.860995e-02 | 0 |
| TF | TF:M00243 | Factor: Egr-1; motif: WTGCGTGGGCGK | Factor: Egr-1; motif: WTGCGTGGGCGK | 106 | 4.001294e-02 | 0 |
| TF | TF:M09973 | Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN | Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN | 184 | 4.079976e-02 | 0 |
| TF | TF:M01770 | Factor: XBP-1; motif: WNNGMCACGTC | Factor: XBP-1; motif: WNNGMCACGTC | 185 | 4.118487e-02 | 0 |
| TF | TF:M07129 | Factor: Sp2; motif: GYCCCGCCYCYNNNN | Factor: Sp2; motif: GYCCCGCCYCYNNNN | 120 | 4.332454e-02 | 0 |
| TF | TF:M00196_1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | 115 | 4.481878e-02 | 0 |
| TF | TF:M11430 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 183 | 4.496793e-02 | 0 |
| TF | TF:M01588_1 | Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 | Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 | 84 | 4.558422e-02 | 0 |
| TF | TF:M03876 | Factor: Kaiso; motif: GCMGGGRGCRGS | Factor: Kaiso; motif: GCMGGGRGCRGS | 218 | 4.608681e-02 | 0 |
| TF | TF:M09895 | Factor: E2F-6; motif: NGGGCGGGARRNN | Factor: E2F-6; motif: NGGGCGGGARRNN | 142 | 4.930489e-02 | 0 |
| TF | TF:M01593 | Factor: Zfx; motif: SNSCAGGCCKCGSCSS | Factor: Zfx; motif: SNSCAGGCCKCGSCSS | 87 | 4.969695e-02 | 0 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:126 | CCT complex (chaperonin containing TCP1 complex) | CCT complex (chaperonin containing TCP1 complex) | 8 | 1.018968e-10 | 0 |
| CORUM | CORUM:6247 | BBS-chaperonin complex | BBS-chaperonin complex | 6 | 2.423719e-05 | 0 |
| CORUM | CORUM:193 | PA700-20S-PA28 complex | PA700-20S-PA28 complex | 9 | 5.989539e-05 | 0 |
| CORUM | CORUM:32 | PA700 complex | PA700 complex | 6 | 3.497578e-03 | 0 |
| CORUM | CORUM:6984 | ProTalpha C2 complex | ProTalpha C2 complex | 3 | 2.042885e-02 | 0 |
| CORUM | CORUM:181 | 26S proteasome | 26S proteasome | 5 | 3.678579e-02 | 0 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-390450 | Folding of actin by CCT/TriC | Folding of actin by CCT/TriC | 8 | 8.174012e-10 | 0 |
| REAC | REAC:R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | Formation of tubulin folding intermediates by CCT/TriC | 11 | 9.532716e-10 | 0 |
| REAC | REAC:R-HSA-9711123 | Cellular response to chemical stress | Cellular response to chemical stress | 25 | 1.215555e-09 | 0 |
| REAC | REAC:R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | Prefoldin mediated transfer of substrate to CCT/TriC | 11 | 2.551558e-09 | 0 |
| REAC | REAC:R-HSA-6798695 | Neutrophil degranulation | Neutrophil degranulation | 37 | 3.018654e-09 | 0 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 48 | 1.520872e-08 | 0 |
| REAC | REAC:R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 11 | 2.092908e-08 | 0 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 48 | 2.802444e-08 | 0 |
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 16 | 6.796993e-08 | 0 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 84 | 1.988082e-07 | 0 |
| REAC | REAC:R-HSA-1430728 | Metabolism | Metabolism | 84 | 4.803760e-07 | 0 |
| REAC | REAC:R-HSA-9755511 | KEAP1-NFE2L2 pathway | KEAP1-NFE2L2 pathway | 17 | 4.989966e-07 | 0 |
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 81 | 4.646425e-06 | 0 |
| REAC | REAC:R-HSA-162909 | Host Interactions of HIV factors | Host Interactions of HIV factors | 16 | 5.483943e-06 | 0 |
| REAC | REAC:R-HSA-1852241 | Organelle biogenesis and maintenance | Organelle biogenesis and maintenance | 24 | 6.674849e-06 | 0 |
| REAC | REAC:R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | AUF1 (hnRNP D0) binds and destabilizes mRNA | 11 | 6.971852e-06 | 0 |
| REAC | REAC:R-HSA-70263 | Gluconeogenesis | Gluconeogenesis | 8 | 1.031173e-05 | 0 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 52 | 1.184000e-05 | 0 |
| REAC | REAC:R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | Regulation of mRNA stability by proteins that bind AU-rich elements | 13 | 1.479998e-05 | 0 |
| REAC | REAC:R-HSA-1234174 | Cellular response to hypoxia | Cellular response to hypoxia | 12 | 2.651863e-05 | 0 |
| REAC | REAC:R-HSA-5678895 | Defective CFTR causes cystic fibrosis | Defective CFTR causes cystic fibrosis | 11 | 2.669566e-05 | 0 |
| REAC | REAC:R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 9 | 3.694218e-05 | 0 |
| REAC | REAC:R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | The role of GTSE1 in G2/M progression after G2 checkpoint | 12 | 4.820692e-05 | 0 |
| REAC | REAC:R-HSA-5358346 | Hedgehog ligand biogenesis | Hedgehog ligand biogenesis | 11 | 5.301141e-05 | 0 |
| REAC | REAC:R-HSA-5358351 | Signaling by Hedgehog | Signaling by Hedgehog | 16 | 5.415666e-05 | 0 |
| REAC | REAC:R-HSA-5610787 | Hedgehog 'off' state | Hedgehog 'off' state | 14 | 5.747920e-05 | 0 |
| REAC | REAC:R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 11 | 6.242932e-05 | 0 |
| REAC | REAC:R-HSA-391251 | Protein folding | Protein folding | 13 | 6.438052e-05 | 0 |
| REAC | REAC:R-HSA-8949613 | Cristae formation | Cristae formation | 8 | 9.719437e-05 | 0 |
| REAC | REAC:R-HSA-5362768 | Hh mutants are degraded by ERAD | Hh mutants are degraded by ERAD | 10 | 1.202430e-04 | 0 |
| REAC | REAC:R-HSA-447115 | Interleukin-12 family signaling | Interleukin-12 family signaling | 10 | 1.697373e-04 | 0 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 70 | 1.899051e-04 | 0 |
| REAC | REAC:R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | NIK-->noncanonical NF-kB signaling | 10 | 2.005908e-04 | 0 |
| REAC | REAC:R-HSA-5387390 | Hh mutants abrogate ligand secretion | Hh mutants abrogate ligand secretion | 10 | 2.005908e-04 | 0 |
| REAC | REAC:R-HSA-1236974 | ER-Phagosome pathway | ER-Phagosome pathway | 12 | 2.095577e-04 | 0 |
| REAC | REAC:R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | Dectin-1 mediated noncanonical NF-kB signaling | 10 | 2.362496e-04 | 0 |
| REAC | REAC:R-HSA-390466 | Chaperonin-mediated protein folding | Chaperonin-mediated protein folding | 12 | 2.368836e-04 | 0 |
| REAC | REAC:R-HSA-3299685 | Detoxification of Reactive Oxygen Species | Detoxification of Reactive Oxygen Species | 8 | 2.693510e-04 | 0 |
| REAC | REAC:R-HSA-9020591 | Interleukin-12 signaling | Interleukin-12 signaling | 9 | 3.155692e-04 | 0 |
| REAC | REAC:R-HSA-5619084 | ABC transporter disorders | ABC transporter disorders | 11 | 3.608780e-04 | 0 |
| REAC | REAC:R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | Cross-presentation of soluble exogenous antigens (endosomes) | 9 | 3.794544e-04 | 0 |
| REAC | REAC:R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | Regulation of activated PAK-2p34 by proteasome mediated degradation | 9 | 4.542299e-04 | 0 |
| REAC | REAC:R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | Downstream signaling events of B Cell Receptor (BCR) | 11 | 4.681793e-04 | 0 |
| REAC | REAC:R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | Association of TriC/CCT with target proteins during biosynthesis | 8 | 5.295539e-04 | 0 |
| REAC | REAC:R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 8 | 5.295539e-04 | 0 |
| REAC | REAC:R-HSA-9837999 | Mitochondrial protein degradation | Mitochondrial protein degradation | 12 | 5.345588e-04 | 0 |
| REAC | REAC:R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | Regulation of ornithine decarboxylase (ODC) | 9 | 5.414118e-04 | 0 |
| REAC | REAC:R-HSA-69610 | p53-Independent DNA Damage Response | p53-Independent DNA Damage Response | 9 | 6.426799e-04 | 0 |
| REAC | REAC:R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint | p53-Independent G1/S DNA damage checkpoint | 9 | 6.426799e-04 | 0 |
| REAC | REAC:R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 9 | 6.426799e-04 | 0 |
| REAC | REAC:R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 9 | 6.426799e-04 | 0 |
| REAC | REAC:R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | Ubiquitin-dependent degradation of Cyclin D | 9 | 6.426799e-04 | 0 |
| REAC | REAC:R-HSA-180534 | Vpu mediated degradation of CD4 | Vpu mediated degradation of CD4 | 9 | 6.426799e-04 | 0 |
| REAC | REAC:R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | Autodegradation of the E3 ubiquitin ligase COP1 | 9 | 6.426799e-04 | 0 |
| REAC | REAC:R-HSA-163210 | Formation of ATP by chemiosmotic coupling | Formation of ATP by chemiosmotic coupling | 6 | 6.532861e-04 | 0 |
| REAC | REAC:R-HSA-5658442 | Regulation of RAS by GAPs | Regulation of RAS by GAPs | 10 | 6.817909e-04 | 0 |
| REAC | REAC:R-HSA-180585 | Vif-mediated degradation of APOBEC3G | Vif-mediated degradation of APOBEC3G | 9 | 7.598908e-04 | 0 |
| REAC | REAC:R-HSA-9604323 | Negative regulation of NOTCH4 signaling | Negative regulation of NOTCH4 signaling | 9 | 7.598908e-04 | 0 |
| REAC | REAC:R-HSA-169911 | Regulation of Apoptosis | Regulation of Apoptosis | 9 | 7.598908e-04 | 0 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 13 | 8.614520e-04 | 0 |
| REAC | REAC:R-HSA-9793380 | Formation of paraxial mesoderm | Formation of paraxial mesoderm | 10 | 9.005359e-04 | 0 |
| REAC | REAC:R-HSA-983169 | Class I MHC mediated antigen processing & presentation | Class I MHC mediated antigen processing & presentation | 24 | 9.471365e-04 | 0 |
| REAC | REAC:R-HSA-8941858 | Regulation of RUNX3 expression and activity | Regulation of RUNX3 expression and activity | 9 | 1.050527e-03 | 0 |
| REAC | REAC:R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | SCF-beta-TrCP mediated degradation of Emi1 | 9 | 1.050527e-03 | 0 |
| REAC | REAC:R-HSA-9824272 | Somitogenesis | Somitogenesis | 9 | 1.050527e-03 | 0 |
| REAC | REAC:R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 9 | 1.050527e-03 | 0 |
| REAC | REAC:R-HSA-4641257 | Degradation of AXIN | Degradation of AXIN | 9 | 1.050527e-03 | 0 |
| REAC | REAC:R-HSA-1236975 | Antigen processing-Cross presentation | Antigen processing-Cross presentation | 12 | 1.125699e-03 | 0 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 10 | 1.178017e-03 | 0 |
| REAC | REAC:R-HSA-4641258 | Degradation of DVL | Degradation of DVL | 9 | 1.432205e-03 | 0 |
| REAC | REAC:R-HSA-69541 | Stabilization of p53 | Stabilization of p53 | 9 | 1.432205e-03 | 0 |
| REAC | REAC:R-HSA-351202 | Metabolism of polyamines | Metabolism of polyamines | 9 | 1.664087e-03 | 0 |
| REAC | REAC:R-HSA-1592230 | Mitochondrial biogenesis | Mitochondrial biogenesis | 11 | 1.720274e-03 | 0 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 13 | 2.111015e-03 | 0 |
| REAC | REAC:R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | GLI3 is processed to GLI3R by the proteasome | 9 | 2.225976e-03 | 0 |
| REAC | REAC:R-HSA-5610780 | Degradation of GLI1 by the proteasome | Degradation of GLI1 by the proteasome | 9 | 2.225976e-03 | 0 |
| REAC | REAC:R-HSA-5610783 | Degradation of GLI2 by the proteasome | Degradation of GLI2 by the proteasome | 9 | 2.225976e-03 | 0 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 9 | 2.225976e-03 | 0 |
| REAC | REAC:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | CLEC7A (Dectin-1) signaling | 11 | 3.230933e-03 | 0 |
| REAC | REAC:R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | BBSome-mediated cargo-targeting to cilium | 6 | 3.247811e-03 | 0 |
| REAC | REAC:R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | Autodegradation of Cdh1 by Cdh1:APC/C | 9 | 3.850376e-03 | 0 |
| REAC | REAC:R-HSA-4608870 | Asymmetric localization of PCP proteins | Asymmetric localization of PCP proteins | 9 | 3.850376e-03 | 0 |
| REAC | REAC:R-HSA-1280215 | Cytokine Signaling in Immune system | Cytokine Signaling in Immune system | 36 | 4.226692e-03 | 0 |
| REAC | REAC:R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | TNFR2 non-canonical NF-kB pathway | 11 | 4.348867e-03 | 0 |
| REAC | REAC:R-HSA-449147 | Signaling by Interleukins | Signaling by Interleukins | 26 | 4.959154e-03 | 0 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 9 | 4.986464e-03 | 0 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 9 | 4.986464e-03 | 0 |
| REAC | REAC:R-HSA-1428517 | Aerobic respiration and respiratory electron transport | Aerobic respiration and respiratory electron transport | 16 | 4.988039e-03 | 0 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 55 | 5.540829e-03 | 0 |
| REAC | REAC:R-HSA-1169091 | Activation of NF-kappaB in B cells | Activation of NF-kappaB in B cells | 9 | 5.654431e-03 | 0 |
| REAC | REAC:R-HSA-382556 | ABC-family proteins mediated transport | ABC-family proteins mediated transport | 11 | 5.789601e-03 | 0 |
| REAC | REAC:R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | APC/C:Cdc20 mediated degradation of Securin | 9 | 6.397295e-03 | 0 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 9 | 6.397295e-03 | 0 |
| REAC | REAC:R-HSA-70171 | Glycolysis | Glycolysis | 9 | 6.397295e-03 | 0 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 14 | 6.489629e-03 | 0 |
| REAC | REAC:R-HSA-8948751 | Regulation of PTEN stability and activity | Regulation of PTEN stability and activity | 9 | 7.221809e-03 | 0 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 13 | 8.049079e-03 | 0 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 38 | 8.793024e-03 | 0 |
| REAC | REAC:R-HSA-8939902 | Regulation of RUNX2 expression and activity | Regulation of RUNX2 expression and activity | 9 | 9.145090e-03 | 0 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 15 | 9.519661e-03 | 0 |
| REAC | REAC:R-HSA-5619115 | Disorders of transmembrane transporters | Disorders of transmembrane transporters | 14 | 9.689039e-03 | 0 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 15 | 1.073490e-02 | 0 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 9 | 1.148775e-02 | 0 |
| REAC | REAC:R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 9 | 1.148775e-02 | 0 |
| REAC | REAC:R-HSA-4086400 | PCP/CE pathway | PCP/CE pathway | 10 | 1.243343e-02 | 0 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 10 | 1.243343e-02 | 0 |
| REAC | REAC:R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 9 | 1.283841e-02 | 0 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 9 | 1.283841e-02 | 0 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 16 | 1.321804e-02 | 0 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 43 | 1.344672e-02 | 0 |
| REAC | REAC:R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 6 | 1.372688e-02 | 0 |
| REAC | REAC:R-HSA-9020702 | Interleukin-1 signaling | Interleukin-1 signaling | 11 | 1.399362e-02 | 0 |
| REAC | REAC:R-HSA-446203 | Asparagine N-linked glycosylation | Asparagine N-linked glycosylation | 19 | 1.411021e-02 | 0 |
| REAC | REAC:R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | APC/C:Cdc20 mediated degradation of mitotic proteins | 9 | 1.594728e-02 | 0 |
| REAC | REAC:R-HSA-5621481 | C-type lectin receptors (CLRs) | C-type lectin receptors (CLRs) | 12 | 1.633055e-02 | 0 |
| REAC | REAC:R-HSA-69002 | DNA Replication Pre-Initiation | DNA Replication Pre-Initiation | 13 | 1.726774e-02 | 0 |
| REAC | REAC:R-HSA-70326 | Glucose metabolism | Glucose metabolism | 9 | 1.772679e-02 | 0 |
| REAC | REAC:R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 9 | 1.772679e-02 | 0 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 15 | 1.910972e-02 | 0 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 13 | 2.100823e-02 | 0 |
| REAC | REAC:R-HSA-202424 | Downstream TCR signaling | Downstream TCR signaling | 10 | 2.159651e-02 | 0 |
| REAC | REAC:R-HSA-9663891 | Selective autophagy | Selective autophagy | 9 | 2.410620e-02 | 0 |
| REAC | REAC:R-HSA-2467813 | Separation of Sister Chromatids | Separation of Sister Chromatids | 14 | 2.443622e-02 | 0 |
| REAC | REAC:R-HSA-9013694 | Signaling by NOTCH4 | Signaling by NOTCH4 | 9 | 2.662244e-02 | 0 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 9 | 2.662244e-02 | 0 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 9 | 2.935667e-02 | 0 |
| REAC | REAC:R-HSA-5689603 | UCH proteinases | UCH proteinases | 10 | 3.048896e-02 | 0 |
| REAC | REAC:R-HSA-195253 | Degradation of beta-catenin by the destruction complex | Degradation of beta-catenin by the destruction complex | 9 | 3.232380e-02 | 0 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 9 | 3.553947e-02 | 0 |
| REAC | REAC:R-HSA-5632684 | Hedgehog 'on' state | Hedgehog 'on' state | 9 | 3.902008e-02 | 0 |
| REAC | REAC:R-HSA-3371511 | HSF1 activation | HSF1 activation | 4 | 4.299377e-02 | 0 |
| REAC | REAC:R-HSA-446652 | Interleukin-1 family signaling | Interleukin-1 family signaling | 12 | 4.550800e-02 | 0 |
| REAC | REAC:R-HSA-3371556 | Cellular response to heat stress | Cellular response to heat stress | 9 | 4.684553e-02 | 0 |
| REAC | REAC:R-HSA-5620920 | Cargo trafficking to the periciliary membrane | Cargo trafficking to the periciliary membrane | 7 | 4.722234e-02 | 0 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 20 | 4.881182e-02 | 0 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 13 | 4.936242e-02 | 0 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0004354 | Abnormal circulating carboxylic acid concentration | Any deviation from the normal concentration of a carboxylic acid in the blood circulation. | 29 | 0.000175 | 0 |
| HP | HP:0003394 | Muscle spasm | Sudden and involuntary contractions of one or more muscles. | 18 | 0.000642 | 0 |
| HP | HP:0033107 | Abnormal circulating proteinogenic amino acid concentration | An elevated level of a proteinogenic amino acid in the blood circulation. These are the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. | 14 | 0.001209 | 0 |
| HP | HP:0001987 | Hyperammonemia | An increased concentration of ammonia in the blood. | 12 | 0.001584 | 0 |
| HP | HP:0430071 | Abnormal circulating organic compound concentration | Any deviation of the concentration of an orrganic compound from the normal range. An organic compound is defined as any compound that contains a carbon atom. | 41 | 0.002215 | 0 |
| HP | HP:0003112 | Abnormal circulating amino acid concentration | The presence of an abnormal decrease or increase of one or more amino acids in the blood circulation. | 17 | 0.003416 | 0 |
| HP | HP:0032180 | Abnormal circulating metabolite concentration | An abnormal level of an analyte measured in the blood. | 60 | 0.019338 | 0 |
| HP | HP:0031993 | Hoffmann sign | A Hoffmann test is performed by flicking the fingernail of the long finger, from dorsal to volar, on each hand while the hand was supported by the examiner's hand. The test was done with the neck in the neutral position and then with the neck maximally forward flexed. Any flexion of the ipsilateral thumb and/or index finger was interpreted as a positive test. | 8 | 0.026681 | 0 |
| HP | HP:0010551 | Paraplegia/paraparesis | Weakness of both lower extremities with sparing of the upper extremities. Paraplegia refers to a severe or complete loss of strength, whereas paraparesis refers to a relatively mild loss of strength. | 19 | 0.029050 | 0 |
| HP | HP:0011804 | Abnormal muscle physiology | A functional abnormality of a skeletal muscle. | 89 | 0.030480 | 0 |
| HP | HP:0002371 | Loss of speech | Loss of speech | 8 | 0.031610 | 0 |
| HP | HP:0002450 | Abnormal motor neuron morphology | Any structural anomaly that affects the motor neuron. | 10 | 0.031839 | 0 |
| HP | HP:0001941 | Acidosis | Abnormal acid accumulation or depletion of base. | 25 | 0.045831 | 0 |
Community 1
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 187 | 1.230806e-76 | 1 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 192 | 1.007799e-61 | 1 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 119 | 7.629136e-54 | 1 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 195 | 2.975037e-50 | 1 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 195 | 2.975037e-50 | 1 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 195 | 2.975037e-50 | 1 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 32 | 8.146934e-42 | 1 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 218 | 4.282098e-38 | 1 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 36 | 4.429682e-36 | 1 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 70 | 1.402809e-35 | 1 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 36 | 2.012167e-34 | 1 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 45 | 9.582796e-33 | 1 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 172 | 1.873031e-32 | 1 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 172 | 1.912406e-32 | 1 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 73 | 3.461946e-26 | 1 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 47 | 1.015745e-25 | 1 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 80 | 6.796218e-25 | 1 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 34 | 7.376205e-25 | 1 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 40 | 3.925052e-23 | 1 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 169 | 1.592761e-20 | 1 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 235 | 5.353508e-20 | 1 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 242 | 1.781177e-17 | 1 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 239 | 4.136994e-17 | 1 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 24 | 9.619301e-17 | 1 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 84 | 5.237872e-16 | 1 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 245 | 1.231900e-15 | 1 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 58 | 8.173632e-15 | 1 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 41 | 2.803864e-14 | 1 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 44 | 7.566339e-14 | 1 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 124 | 8.792124e-14 | 1 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 25 | 1.150207e-13 | 1 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 45 | 1.621107e-13 | 1 |
| GO:CC | GO:0032993 | protein-DNA complex | "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] | 24 | 3.266034e-13 | 1 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 248 | 7.937100e-13 | 1 |
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 15 | 2.537106e-12 | 1 |
| GO:CC | GO:0000793 | condensed chromosome | "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] | 23 | 1.104631e-10 | 1 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 64 | 1.127113e-07 | 1 |
| GO:CC | GO:0043596 | nuclear replication fork | "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] | 9 | 2.947480e-07 | 1 |
| GO:CC | GO:0070533 | BRCA1-C complex | "A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint." [GOC:mah, PMID:15485915, PMID:16391231] | 5 | 4.346689e-07 | 1 |
| GO:CC | GO:0032806 | carboxy-terminal domain protein kinase complex | "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683] | 7 | 6.332986e-07 | 1 |
| GO:CC | GO:0000775 | chromosome, centromeric region | "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] | 18 | 6.615524e-07 | 1 |
| GO:CC | GO:0000794 | condensed nuclear chromosome | "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh] | 11 | 9.720843e-07 | 1 |
| GO:CC | GO:0016363 | nuclear matrix | "A dynamic, proteinaceous framework within the nucleus of eukaryotic cells, composed of proteins and RNA, that provides structural support for chromatin organization, gene regulation, and nuclear processes." [PMID:15608168, PMID:3058729, PMID:39789220] | 13 | 1.245192e-06 | 1 |
| GO:CC | GO:0043073 | germ cell nucleus | "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators] | 10 | 3.214767e-06 | 1 |
| GO:CC | GO:0000123 | histone acetyltransferase complex | "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] | 11 | 3.372138e-06 | 1 |
| GO:CC | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] | 7 | 5.066089e-06 | 1 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 32 | 5.111031e-06 | 1 |
| GO:CC | GO:0070516 | CAK-ERCC2 complex | "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2." [PMID:8692841, PMID:8692842] | 4 | 6.452299e-06 | 1 |
| GO:CC | GO:0031248 | protein acetyltransferase complex | "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf] | 11 | 1.010022e-05 | 1 |
| GO:CC | GO:1902493 | acetyltransferase complex | "A protein complex which is capable of acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 11 | 1.119397e-05 | 1 |
| GO:CC | GO:0005819 | spindle | "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] | 21 | 1.595477e-05 | 1 |
| GO:CC | GO:0000791 | euchromatin | "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156] | 9 | 1.840012e-05 | 1 |
| GO:CC | GO:0000152 | nuclear ubiquitin ligase complex | "A ubiquitin ligase complex found in the nucleus." [GOC:mah] | 8 | 3.118970e-05 | 1 |
| GO:CC | GO:0071162 | CMG complex | "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417] | 5 | 3.192549e-05 | 1 |
| GO:CC | GO:0000428 | DNA-directed RNA polymerase complex | "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] | 11 | 5.032553e-05 | 1 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 184 | 6.330453e-05 | 1 |
| GO:CC | GO:0005635 | nuclear envelope | "The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport." [ISBN:0198547684, PMID:16164970] | 22 | 6.475356e-05 | 1 |
| GO:CC | GO:0030880 | RNA polymerase complex | "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah] | 11 | 6.498219e-05 | 1 |
| GO:CC | GO:0031261 | DNA replication preinitiation complex | "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184] | 5 | 8.727225e-05 | 1 |
| GO:CC | GO:0072686 | mitotic spindle | "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] | 13 | 9.276043e-05 | 1 |
| GO:CC | GO:0030894 | replisome | "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] | 6 | 9.337313e-05 | 1 |
| GO:CC | GO:0017053 | transcription repressor complex | "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] | 9 | 1.183358e-04 | 1 |
| GO:CC | GO:0031461 | cullin-RING ubiquitin ligase complex | "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] | 13 | 1.261484e-04 | 1 |
| GO:CC | GO:0000792 | heterochromatin | "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] | 9 | 1.815780e-04 | 1 |
| GO:CC | GO:0055029 | nuclear DNA-directed RNA polymerase complex | "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu] | 10 | 2.831873e-04 | 1 |
| GO:CC | GO:0000776 | kinetochore | "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] | 12 | 3.108211e-04 | 1 |
| GO:CC | GO:0000151 | ubiquitin ligase complex | "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] | 16 | 4.446238e-04 | 1 |
| GO:CC | GO:0097124 | cyclin A2-CDK2 complex | "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 3 | 5.670342e-04 | 1 |
| GO:CC | GO:0070985 | transcription factor TFIIK complex | "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993] | 3 | 5.670342e-04 | 1 |
| GO:CC | GO:0097134 | cyclin E1-CDK2 complex | "A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 3 | 5.670342e-04 | 1 |
| GO:CC | GO:0000779 | condensed chromosome, centromeric region | "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] | 12 | 6.315572e-04 | 1 |
| GO:CC | GO:0042575 | DNA polymerase complex | "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, PMID:12045093] | 5 | 9.841915e-04 | 1 |
| GO:CC | GO:0001673 | male germ cell nucleus | "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu] | 7 | 1.175934e-03 | 1 |
| GO:CC | GO:0043601 | nuclear replisome | "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] | 5 | 1.640486e-03 | 1 |
| GO:CC | GO:0016605 | PML body | "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585] | 9 | 1.683188e-03 | 1 |
| GO:CC | GO:0042555 | MCM complex | "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] | 4 | 1.997863e-03 | 1 |
| GO:CC | GO:0000439 | transcription factor TFIIH core complex | "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] | 4 | 1.997863e-03 | 1 |
| GO:CC | GO:0005680 | anaphase-promoting complex | "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] | 5 | 2.076535e-03 | 1 |
| GO:CC | GO:1990391 | DNA repair complex | "A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350] | 5 | 2.076535e-03 | 1 |
| GO:CC | GO:0035189 | Rb-E2F complex | "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073] | 3 | 2.248780e-03 | 1 |
| GO:CC | GO:0005675 | transcription factor TFIIH holo complex | "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] | 4 | 2.969687e-03 | 1 |
| GO:CC | GO:0000922 | spindle pole | "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] | 11 | 3.038852e-03 | 1 |
| GO:CC | GO:0005677 | chromatin silencing complex | "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] | 4 | 4.250760e-03 | 1 |
| GO:CC | GO:0070603 | SWI/SNF superfamily-type complex | "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938] | 8 | 5.329604e-03 | 1 |
| GO:CC | GO:0005658 | alpha DNA polymerase:primase complex | "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a small stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402, PMID:26975377] | 3 | 5.573996e-03 | 1 |
| GO:CC | GO:0016602 | CCAAT-binding factor complex | "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851] | 3 | 5.573996e-03 | 1 |
| GO:CC | GO:0070418 | DNA-dependent protein kinase complex | "A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku." [GOC:mah, PMID:10854421, PMID:12235392] | 3 | 5.573996e-03 | 1 |
| GO:CC | GO:0035861 | site of double-strand break | "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] | 8 | 6.698438e-03 | 1 |
| GO:CC | GO:0090734 | site of DNA damage | "A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg] | 9 | 7.152304e-03 | 1 |
| GO:CC | GO:0031965 | nuclear membrane | "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] | 14 | 8.747092e-03 | 1 |
| GO:CC | GO:0000800 | lateral element | "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh] | 4 | 1.052945e-02 | 1 |
| GO:CC | GO:0030870 | Mre11 complex | "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145] | 3 | 1.105295e-02 | 1 |
| GO:CC | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex | "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV." [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889] | 3 | 1.917786e-02 | 1 |
| GO:CC | GO:0030893 | meiotic cohesin complex | "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522] | 3 | 1.917786e-02 | 1 |
| GO:CC | GO:0071144 | heteromeric SMAD protein complex | "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020] | 3 | 3.042327e-02 | 1 |
| GO:CC | GO:0008024 | cyclin/CDK positive transcription elongation factor complex | "A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit." [GOC:bhm, GOC:vw, PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473] | 3 | 3.042327e-02 | 1 |
| GO:CC | GO:0000808 | origin recognition complex | "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] | 3 | 3.042327e-02 | 1 |
| GO:CC | GO:0005664 | nuclear origin of replication recognition complex | "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] | 3 | 3.042327e-02 | 1 |
| GO:CC | GO:0000795 | synaptonemal complex | "A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element." [DOI:10.5772/29752, GOC:elh] | 5 | 3.905335e-02 | 1 |
| GO:CC | GO:0099086 | synaptonemal structure | "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh, GOC:vw] | 5 | 3.905335e-02 | 1 |
| GO:CC | GO:0044297 | cell body | "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] | 18 | 4.222757e-02 | 1 |
| GO:CC | GO:0070419 | nonhomologous end joining complex | "A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends." [GOC:mah, PMID:17072889, PMID:17938628] | 3 | 4.524650e-02 | 1 |
| GO:CC | GO:0071141 | SMAD protein complex | "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020] | 3 | 4.524650e-02 | 1 |
| GO:CC | GO:1904949 | ATPase complex | "A protein complex which is capable of ATPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181] | 8 | 4.526776e-02 | 1 |
| GO:CC | GO:1902562 | H4 histone acetyltransferase complex | "A protein complex which is capable of H4 histone acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:23775086] | 5 | 4.923267e-02 | 1 |
| GO:CC | GO:0002945 | cyclin K-CDK13 complex | "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] | 2 | 4.963678e-02 | 1 |
| GO:CC | GO:0097131 | cyclin D1-CDK6 complex | "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.963678e-02 | 1 |
| GO:CC | GO:0097133 | cyclin D3-CDK6 complex | "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.963678e-02 | 1 |
| GO:CC | GO:0097122 | cyclin A2-CDK1 complex | "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.963678e-02 | 1 |
| GO:CC | GO:0097121 | cyclin A1-CDK1 complex | "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.963678e-02 | 1 |
| GO:CC | GO:0097123 | cyclin A1-CDK2 complex | "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.963678e-02 | 1 |
| GO:CC | GO:0070557 | PCNA-p21 complex | "A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication." [GOC:mah, PMID:7911228, PMID:7915843] | 2 | 4.963678e-02 | 1 |
| GO:CC | GO:0097128 | cyclin D1-CDK4 complex | "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.963678e-02 | 1 |
| GO:CC | GO:0097125 | cyclin B1-CDK1 complex | "A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.963678e-02 | 1 |
| GO:CC | GO:0097135 | cyclin E2-CDK2 complex | "A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.963678e-02 | 1 |
| GO:CC | GO:0097130 | cyclin D3-CDK4 complex | "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.963678e-02 | 1 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 132 | 1.108857e-73 | 1 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 96 | 1.739849e-69 | 1 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 102 | 3.140363e-69 | 1 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 102 | 1.249397e-60 | 1 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 97 | 2.853401e-58 | 1 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 77 | 5.776435e-58 | 1 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 71 | 2.935176e-57 | 1 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 105 | 7.125154e-57 | 1 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 59 | 7.559541e-53 | 1 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 66 | 1.342746e-46 | 1 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 79 | 1.736055e-42 | 1 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 59 | 6.847564e-42 | 1 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 172 | 9.586704e-42 | 1 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 53 | 6.199971e-41 | 1 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 66 | 5.235025e-40 | 1 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 68 | 4.998504e-38 | 1 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 182 | 2.020910e-37 | 1 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 99 | 1.310601e-36 | 1 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 187 | 8.195635e-36 | 1 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 57 | 1.344335e-35 | 1 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 41 | 4.549441e-35 | 1 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 42 | 5.785424e-34 | 1 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 139 | 7.977343e-34 | 1 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 124 | 4.356924e-32 | 1 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 48 | 1.233435e-31 | 1 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 59 | 4.268028e-31 | 1 |
| GO:BP | GO:0006261 | DNA-templated DNA replication | "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] | 35 | 9.849643e-31 | 1 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 127 | 3.282763e-30 | 1 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 93 | 5.261408e-28 | 1 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 157 | 1.045786e-25 | 1 |
| GO:BP | GO:0044839 | cell cycle G2/M phase transition | "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle] | 31 | 1.526326e-25 | 1 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 50 | 3.582758e-25 | 1 |
| GO:BP | GO:0006275 | regulation of DNA replication | "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] | 28 | 6.253289e-25 | 1 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 125 | 7.858483e-25 | 1 |
| GO:BP | GO:0000086 | G2/M transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] | 29 | 2.179070e-24 | 1 |
| GO:BP | GO:0010389 | regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565] | 26 | 1.023868e-23 | 1 |
| GO:BP | GO:1902749 | regulation of cell cycle G2/M phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 27 | 1.046878e-23 | 1 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 113 | 3.638174e-23 | 1 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 113 | 5.919735e-23 | 1 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 115 | 7.157550e-23 | 1 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 157 | 8.886045e-23 | 1 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 102 | 9.526518e-23 | 1 |
| GO:BP | GO:0016310 | phosphorylation | "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] | 69 | 1.228957e-22 | 1 |
| GO:BP | GO:0010948 | negative regulation of cell cycle process | "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 36 | 1.241049e-22 | 1 |
| GO:BP | GO:0008283 | cell population proliferation | "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] | 85 | 1.411458e-22 | 1 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 74 | 1.482214e-22 | 1 |
| GO:BP | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] | 23 | 2.202616e-22 | 1 |
| GO:BP | GO:0051338 | regulation of transferase activity | "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] | 44 | 5.188736e-22 | 1 |
| GO:BP | GO:0045787 | positive regulation of cell cycle | "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] | 38 | 8.654501e-22 | 1 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 72 | 1.158228e-21 | 1 |
| GO:BP | GO:1901988 | negative regulation of cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 33 | 1.831645e-21 | 1 |
| GO:BP | GO:0006468 | protein phosphorylation | "The process of introducing a phosphate group on to a protein." [GOC:hb] | 65 | 2.233606e-21 | 1 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 114 | 8.120633e-21 | 1 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 102 | 1.361702e-20 | 1 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 75 | 1.725473e-20 | 1 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 75 | 1.854181e-20 | 1 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 59 | 2.500681e-20 | 1 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 34 | 2.641716e-20 | 1 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 78 | 3.740527e-20 | 1 |
| GO:BP | GO:0006270 | DNA replication initiation | "The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641] | 17 | 3.823317e-20 | 1 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 167 | 1.444444e-19 | 1 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 26 | 1.995138e-19 | 1 |
| GO:BP | GO:0045930 | negative regulation of mitotic cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 30 | 2.584139e-19 | 1 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 218 | 3.083911e-19 | 1 |
| GO:BP | GO:0006325 | chromatin organization | "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] | 53 | 3.762023e-19 | 1 |
| GO:BP | GO:0051321 | meiotic cell cycle | "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] | 33 | 6.185953e-19 | 1 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 63 | 6.723243e-19 | 1 |
| GO:BP | GO:0000280 | nuclear division | "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] | 39 | 8.314355e-19 | 1 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 93 | 1.001042e-18 | 1 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] | 72 | 1.280655e-18 | 1 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 63 | 1.286407e-18 | 1 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 75 | 1.931176e-18 | 1 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 90 | 1.944635e-18 | 1 |
| GO:BP | GO:0000075 | cell cycle checkpoint signaling | "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] | 27 | 3.310989e-18 | 1 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 140 | 3.317353e-18 | 1 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 53 | 3.455296e-18 | 1 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 138 | 5.605117e-18 | 1 |
| GO:BP | GO:0006302 | double-strand break repair | "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] | 33 | 5.933152e-18 | 1 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 171 | 6.649726e-18 | 1 |
| GO:BP | GO:1901991 | negative regulation of mitotic cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 26 | 7.567225e-18 | 1 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 89 | 1.152677e-17 | 1 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 26 | 1.382944e-17 | 1 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 64 | 1.412826e-17 | 1 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 141 | 1.754254e-17 | 1 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 218 | 1.834377e-17 | 1 |
| GO:BP | GO:0033044 | regulation of chromosome organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] | 29 | 2.866848e-17 | 1 |
| GO:BP | GO:0048285 | organelle fission | "The creation of two or more organelles by division of one organelle." [GOC:jid] | 39 | 3.073398e-17 | 1 |
| GO:BP | GO:0006338 | chromatin remodeling | "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] | 46 | 3.564292e-17 | 1 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 25 | 3.626362e-17 | 1 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 90 | 4.113009e-17 | 1 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 161 | 8.679004e-17 | 1 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 140 | 8.793096e-17 | 1 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 213 | 9.416687e-17 | 1 |
| GO:BP | GO:0043549 | regulation of kinase activity | "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] | 36 | 1.097968e-16 | 1 |
| GO:BP | GO:0031570 | DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] | 22 | 2.079192e-16 | 1 |
| GO:BP | GO:1901992 | positive regulation of mitotic cell cycle phase transition | "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 20 | 2.081505e-16 | 1 |
| GO:BP | GO:0045931 | positive regulation of mitotic cell cycle | "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 22 | 2.500759e-16 | 1 |
| GO:BP | GO:0090068 | positive regulation of cell cycle process | "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 29 | 2.667957e-16 | 1 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 136 | 3.023048e-16 | 1 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 51 | 4.299124e-16 | 1 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] | 51 | 4.496086e-16 | 1 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 100 | 6.490618e-16 | 1 |
| GO:BP | GO:0006310 | DNA recombination | "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] | 32 | 7.922888e-16 | 1 |
| GO:BP | GO:0050789 | regulation of biological process | "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] | 215 | 1.092142e-15 | 1 |
| GO:BP | GO:0042325 | regulation of phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] | 47 | 1.300481e-15 | 1 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 25 | 1.634700e-15 | 1 |
| GO:BP | GO:0007093 | mitotic cell cycle checkpoint signaling | "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] | 22 | 2.019839e-15 | 1 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 57 | 4.323575e-15 | 1 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 120 | 5.375232e-15 | 1 |
| GO:BP | GO:0007059 | chromosome segregation | "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] | 34 | 5.685468e-15 | 1 |
| GO:BP | GO:0098813 | nuclear chromosome segregation | "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos] | 30 | 8.930558e-15 | 1 |
| GO:BP | GO:0022616 | DNA strand elongation | "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:isa_complete, GOC:mah] | 14 | 9.536425e-15 | 1 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 94 | 1.021528e-14 | 1 |
| GO:BP | GO:1901989 | positive regulation of cell cycle phase transition | "Any process that activates or increases the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 20 | 1.501963e-14 | 1 |
| GO:BP | GO:0000725 | recombinational repair | "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] | 24 | 2.799647e-14 | 1 |
| GO:BP | GO:0071900 | regulation of protein serine/threonine kinase activity | "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] | 26 | 4.691311e-14 | 1 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] | 43 | 1.246925e-13 | 1 |
| GO:BP | GO:0065007 | biological regulation | "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 215 | 1.874386e-13 | 1 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 22 | 3.568551e-13 | 1 |
| GO:BP | GO:0045859 | regulation of protein kinase activity | "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] | 31 | 4.794749e-13 | 1 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 77 | 7.783024e-13 | 1 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 77 | 8.340785e-13 | 1 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 173 | 8.372155e-13 | 1 |
| GO:BP | GO:0044774 | mitotic DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle] | 16 | 9.439258e-13 | 1 |
| GO:BP | GO:0140014 | mitotic nuclear division | "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684] | 26 | 2.006532e-12 | 1 |
| GO:BP | GO:0048144 | fibroblast proliferation | "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] | 18 | 2.117321e-12 | 1 |
| GO:BP | GO:0033260 | nuclear DNA replication | "The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] | 13 | 2.264703e-12 | 1 |
| GO:BP | GO:0000724 | double-strand break repair via homologous recombination | "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] | 22 | 2.409506e-12 | 1 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 57 | 3.904080e-12 | 1 |
| GO:BP | GO:0000077 | DNA damage checkpoint signaling | "A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah] | 18 | 4.818897e-12 | 1 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 66 | 7.078778e-12 | 1 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 225 | 8.959945e-12 | 1 |
| GO:BP | GO:0044786 | cell cycle DNA replication | "The DNA-dependent DNA replication that takes place as part of the cell cycle." [GOC:mtg_cell_cycle] | 13 | 8.988611e-12 | 1 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 67 | 9.746445e-12 | 1 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 67 | 1.075224e-11 | 1 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 57 | 1.412236e-11 | 1 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] | 38 | 2.193304e-11 | 1 |
| GO:BP | GO:0009314 | response to radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] | 30 | 3.373820e-11 | 1 |
| GO:BP | GO:0042770 | signal transduction in response to DNA damage | "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators] | 20 | 6.272107e-11 | 1 |
| GO:BP | GO:0009411 | response to UV | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] | 19 | 9.510069e-11 | 1 |
| GO:BP | GO:1903046 | meiotic cell cycle process | "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 22 | 9.565347e-11 | 1 |
| GO:BP | GO:0006282 | regulation of DNA repair | "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] | 22 | 1.048896e-10 | 1 |
| GO:BP | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 14 | 1.710901e-10 | 1 |
| GO:BP | GO:0044773 | mitotic DNA damage checkpoint signaling | "A signal transduction process involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] | 14 | 2.115739e-10 | 1 |
| GO:BP | GO:0061982 | meiosis I cell cycle process | "A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs." [PMID:29385397] | 18 | 2.195737e-10 | 1 |
| GO:BP | GO:0000819 | sister chromatid segregation | "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] | 22 | 2.354347e-10 | 1 |
| GO:BP | GO:1902750 | negative regulation of cell cycle G2/M phase transition | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 14 | 2.607191e-10 | 1 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 78 | 3.026163e-10 | 1 |
| GO:BP | GO:0019953 | sexual reproduction | "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] | 46 | 5.633142e-10 | 1 |
| GO:BP | GO:0022414 | reproductive process | "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] | 56 | 8.208040e-10 | 1 |
| GO:BP | GO:0048511 | rhythmic process | "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] | 24 | 8.747385e-10 | 1 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 91 | 1.066880e-09 | 1 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 78 | 1.096065e-09 | 1 |
| GO:BP | GO:0009628 | response to abiotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] | 46 | 1.118505e-09 | 1 |
| GO:BP | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb] | 10 | 1.202075e-09 | 1 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] | 41 | 2.995703e-09 | 1 |
| GO:BP | GO:1902751 | positive regulation of cell cycle G2/M phase transition | "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 10 | 3.934961e-09 | 1 |
| GO:BP | GO:0044818 | mitotic G2/M transition checkpoint | "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] | 12 | 4.154387e-09 | 1 |
| GO:BP | GO:0030174 | regulation of DNA-templated DNA replication initiation | "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah] | 8 | 4.822974e-09 | 1 |
| GO:BP | GO:0006271 | DNA strand elongation involved in DNA replication | "The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication." [GOC:mah, ISBN:071673706X, ISBN:0815316194] | 8 | 4.822974e-09 | 1 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 15 | 4.845267e-09 | 1 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 45 | 4.984101e-09 | 1 |
| GO:BP | GO:0000070 | mitotic sister chromatid segregation | "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] | 19 | 5.148209e-09 | 1 |
| GO:BP | GO:0045740 | positive regulation of DNA replication | "Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators] | 11 | 5.283922e-09 | 1 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 40 | 7.414086e-09 | 1 |
| GO:BP | GO:0140013 | meiotic nuclear division | "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324] | 19 | 1.158733e-08 | 1 |
| GO:BP | GO:0051347 | positive regulation of transferase activity | "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] | 22 | 2.653120e-08 | 1 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 31 | 2.801815e-08 | 1 |
| GO:BP | GO:0010212 | response to ionizing radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] | 16 | 3.286667e-08 | 1 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 23 | 4.490786e-08 | 1 |
| GO:BP | GO:0000727 | double-strand break repair via break-induced replication | "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855] | 7 | 5.140885e-08 | 1 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 130 | 5.560482e-08 | 1 |
| GO:BP | GO:0090329 | regulation of DNA-templated DNA replication | "Any process that modulates the rate, frequency, or extent of DNA-templated DNA replication, the process in which new strands of DNA are synthesized." [GOC:dph, GOC:tb] | 10 | 6.833646e-08 | 1 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 104 | 7.096992e-08 | 1 |
| GO:BP | GO:0010165 | response to X-ray | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] | 9 | 7.682638e-08 | 1 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 122 | 7.867153e-08 | 1 |
| GO:BP | GO:0080135 | regulation of cellular response to stress | "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 28 | 8.569026e-08 | 1 |
| GO:BP | GO:0044093 | positive regulation of molecular function | "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 37 | 8.970249e-08 | 1 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 22 | 1.073413e-07 | 1 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 67 | 1.181169e-07 | 1 |
| GO:BP | GO:0048145 | regulation of fibroblast proliferation | "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] | 13 | 1.247677e-07 | 1 |
| GO:BP | GO:0009416 | response to light stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] | 22 | 1.450845e-07 | 1 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 14 | 1.674158e-07 | 1 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 40 | 1.679930e-07 | 1 |
| GO:BP | GO:0071478 | cellular response to radiation | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:mah] | 17 | 1.730897e-07 | 1 |
| GO:BP | GO:0045005 | DNA-templated DNA replication maintenance of fidelity | "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw] | 11 | 2.166921e-07 | 1 |
| GO:BP | GO:0045739 | positive regulation of DNA repair | "Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators] | 15 | 2.394438e-07 | 1 |
| GO:BP | GO:0040007 | growth | "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] | 37 | 3.644833e-07 | 1 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 21 | 4.953098e-07 | 1 |
| GO:BP | GO:0001701 | in utero embryonic development | "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] | 24 | 5.091534e-07 | 1 |
| GO:BP | GO:0090398 | cellular senescence | "A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest." [GOC:BHF, PMID:28682291] | 13 | 5.505568e-07 | 1 |
| GO:BP | GO:0009790 | embryo development | "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] | 41 | 6.494982e-07 | 1 |
| GO:BP | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis] | 12 | 6.793372e-07 | 1 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 130 | 7.087002e-07 | 1 |
| GO:BP | GO:0045926 | negative regulation of growth | "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] | 18 | 7.665103e-07 | 1 |
| GO:BP | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] | 13 | 9.022932e-07 | 1 |
| GO:BP | GO:0031297 | replication fork processing | "The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542] | 10 | 9.163699e-07 | 1 |
| GO:BP | GO:0110025 | DNA strand resection involved in replication fork processing | "The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing." [GOC:mah, PMID:28475874] | 6 | 1.163511e-06 | 1 |
| GO:BP | GO:1902969 | mitotic DNA replication | "Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] | 7 | 1.198595e-06 | 1 |
| GO:BP | GO:0051402 | neuron apoptotic process | "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis] | 20 | 1.255411e-06 | 1 |
| GO:BP | GO:0050793 | regulation of developmental process | "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] | 65 | 1.349976e-06 | 1 |
| GO:BP | GO:0051983 | regulation of chromosome segregation | "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] | 14 | 1.538759e-06 | 1 |
| GO:BP | GO:0045595 | regulation of cell differentiation | "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] | 49 | 1.629836e-06 | 1 |
| GO:BP | GO:0007127 | meiosis I | "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324] | 14 | 1.701396e-06 | 1 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] | 27 | 1.834417e-06 | 1 |
| GO:BP | GO:0048513 | animal organ development | "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] | 75 | 2.000016e-06 | 1 |
| GO:BP | GO:0043523 | regulation of neuron apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] | 18 | 2.007352e-06 | 1 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 73 | 2.103491e-06 | 1 |
| GO:BP | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 10 | 2.421400e-06 | 1 |
| GO:BP | GO:0080134 | regulation of response to stress | "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 45 | 2.430773e-06 | 1 |
| GO:BP | GO:0009888 | tissue development | "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] | 57 | 2.449263e-06 | 1 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 15 | 3.044126e-06 | 1 |
| GO:BP | GO:0051053 | negative regulation of DNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 14 | 3.053629e-06 | 1 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] | 30 | 3.215302e-06 | 1 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 25 | 3.425096e-06 | 1 |
| GO:BP | GO:0051984 | positive regulation of chromosome segregation | "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] | 8 | 3.748167e-06 | 1 |
| GO:BP | GO:0030154 | cell differentiation | "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] | 95 | 4.061470e-06 | 1 |
| GO:BP | GO:0048869 | cellular developmental process | "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] | 95 | 4.111185e-06 | 1 |
| GO:BP | GO:2000779 | regulation of double-strand break repair | "Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF] | 14 | 4.437481e-06 | 1 |
| GO:BP | GO:0051093 | negative regulation of developmental process | "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 35 | 4.564491e-06 | 1 |
| GO:BP | GO:1902807 | negative regulation of cell cycle G1/S phase transition | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 10 | 5.814953e-06 | 1 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 26 | 6.205192e-06 | 1 |
| GO:BP | GO:0043009 | chordate embryonic development | "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] | 29 | 6.582015e-06 | 1 |
| GO:BP | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] | 9 | 7.061371e-06 | 1 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 37 | 7.974926e-06 | 1 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 28 | 8.666950e-06 | 1 |
| GO:BP | GO:0008315 | G2/MI transition of meiotic cell cycle | "The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I." [PMID:15084480] | 5 | 9.989820e-06 | 1 |
| GO:BP | GO:0051169 | nuclear transport | "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] | 20 | 1.007673e-05 | 1 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] | 20 | 1.007673e-05 | 1 |
| GO:BP | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators, GOC:pr] | 8 | 1.114984e-05 | 1 |
| GO:BP | GO:0104004 | cellular response to environmental stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus." [GOC:dos] | 20 | 1.296563e-05 | 1 |
| GO:BP | GO:0071214 | cellular response to abiotic stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah] | 20 | 1.296563e-05 | 1 |
| GO:BP | GO:0033045 | regulation of sister chromatid segregation | "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] | 12 | 1.344585e-05 | 1 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 130 | 1.428347e-05 | 1 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 33 | 1.445065e-05 | 1 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] | 44 | 1.475343e-05 | 1 |
| GO:BP | GO:0051098 | regulation of binding | "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] | 16 | 1.512446e-05 | 1 |
| GO:BP | GO:0070482 | response to oxygen levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] | 20 | 1.660597e-05 | 1 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 144 | 1.726202e-05 | 1 |
| GO:BP | GO:0051445 | regulation of meiotic cell cycle | "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 10 | 1.740484e-05 | 1 |
| GO:BP | GO:0006301 | postreplication repair | "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh] | 8 | 1.819779e-05 | 1 |
| GO:BP | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity | "Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] | 8 | 1.819779e-05 | 1 |
| GO:BP | GO:0043687 | post-translational protein modification | "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] | 36 | 1.945484e-05 | 1 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 45 | 2.152039e-05 | 1 |
| GO:BP | GO:0010332 | response to gamma radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators] | 9 | 2.213283e-05 | 1 |
| GO:BP | GO:0007095 | mitotic G2 DNA damage checkpoint signaling | "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494] | 8 | 2.297597e-05 | 1 |
| GO:BP | GO:0042221 | response to chemical | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] | 85 | 2.302517e-05 | 1 |
| GO:BP | GO:0021700 | developmental maturation | "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 20 | 2.444542e-05 | 1 |
| GO:BP | GO:0048731 | system development | "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] | 87 | 2.624276e-05 | 1 |
| GO:BP | GO:0044771 | meiotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase." [GOC:mtg_cell_cycle] | 6 | 2.635223e-05 | 1 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 22 | 2.995054e-05 | 1 |
| GO:BP | GO:0006606 | protein import into nucleus | "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] | 14 | 3.070892e-05 | 1 |
| GO:BP | GO:0071479 | cellular response to ionizing radiation | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah] | 10 | 3.076310e-05 | 1 |
| GO:BP | GO:0072359 | circulatory system development | "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] | 38 | 3.124932e-05 | 1 |
| GO:BP | GO:0048146 | positive regulation of fibroblast proliferation | "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] | 9 | 3.132351e-05 | 1 |
| GO:BP | GO:2000781 | positive regulation of double-strand break repair | "Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF] | 11 | 3.283315e-05 | 1 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 33 | 3.354009e-05 | 1 |
| GO:BP | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah] | 13 | 3.780318e-05 | 1 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 39 | 4.252263e-05 | 1 |
| GO:BP | GO:0051170 | import into nucleus | "The directed movement of substances into the nucleus." [GOC:ai] | 14 | 4.484524e-05 | 1 |
| GO:BP | GO:1903844 | regulation of cellular response to transforming growth factor beta stimulus | "Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] | 13 | 4.862151e-05 | 1 |
| GO:BP | GO:0040008 | regulation of growth | "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] | 26 | 4.879048e-05 | 1 |
| GO:BP | GO:0040029 | epigenetic regulation of gene expression | "A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474] | 18 | 5.547246e-05 | 1 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 145 | 5.576743e-05 | 1 |
| GO:BP | GO:0043065 | positive regulation of apoptotic process | "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 24 | 6.260775e-05 | 1 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 160 | 7.120004e-05 | 1 |
| GO:BP | GO:0007179 | transforming growth factor beta receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] | 15 | 7.731004e-05 | 1 |
| GO:BP | GO:0051094 | positive regulation of developmental process | "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 41 | 8.153021e-05 | 1 |
| GO:BP | GO:0034502 | protein localization to chromosome | "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah] | 12 | 8.617874e-05 | 1 |
| GO:BP | GO:0006352 | DNA-templated transcription initiation | "The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161] | 15 | 8.778494e-05 | 1 |
| GO:BP | GO:0048469 | cell maturation | "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state." [GOC:go_curators] | 15 | 9.349188e-05 | 1 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] | 56 | 9.660704e-05 | 1 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 27 | 1.005944e-04 | 1 |
| GO:BP | GO:0071695 | anatomical structure maturation | "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah] | 17 | 1.027952e-04 | 1 |
| GO:BP | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 8 | 1.179716e-04 | 1 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] | 68 | 1.494099e-04 | 1 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] | 38 | 1.744953e-04 | 1 |
| GO:BP | GO:0033674 | positive regulation of kinase activity | "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] | 16 | 1.788779e-04 | 1 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 24 | 1.878920e-04 | 1 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 24 | 1.878920e-04 | 1 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 31 | 1.994254e-04 | 1 |
| GO:BP | GO:0007507 | heart development | "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] | 25 | 2.012733e-04 | 1 |
| GO:BP | GO:0110030 | regulation of G2/MI transition of meiotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw] | 4 | 2.012754e-04 | 1 |
| GO:BP | GO:0030218 | erythrocyte differentiation | "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah] | 12 | 2.017140e-04 | 1 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 46 | 2.277123e-04 | 1 |
| GO:BP | GO:0001934 | positive regulation of protein phosphorylation | "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] | 22 | 2.320858e-04 | 1 |
| GO:BP | GO:0060429 | epithelium development | "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] | 38 | 2.382829e-04 | 1 |
| GO:BP | GO:0030855 | epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] | 28 | 2.458955e-04 | 1 |
| GO:BP | GO:0018394 | peptidyl-lysine acetylation | "The acetylation of peptidyl-lysine." [GOC:mah] | 6 | 2.687730e-04 | 1 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 19 | 2.687996e-04 | 1 |
| GO:BP | GO:0034644 | cellular response to UV | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah] | 10 | 2.711134e-04 | 1 |
| GO:BP | GO:0071824 | protein-DNA complex organization | "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." [GOC:mah] | 16 | 2.736265e-04 | 1 |
| GO:BP | GO:0045165 | cell fate commitment | "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185] | 17 | 2.805687e-04 | 1 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 83 | 2.932661e-04 | 1 |
| GO:BP | GO:0060284 | regulation of cell development | "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] | 30 | 2.974121e-04 | 1 |
| GO:BP | GO:0048589 | developmental growth | "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] | 26 | 3.069992e-04 | 1 |
| GO:BP | GO:0006303 | double-strand break repair via nonhomologous end joining | "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021] | 9 | 3.235535e-04 | 1 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] | 30 | 3.459890e-04 | 1 |
| GO:BP | GO:0048732 | gland development | "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] | 21 | 3.523684e-04 | 1 |
| GO:BP | GO:0001666 | response to hypoxia | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] | 17 | 3.558967e-04 | 1 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] | 16 | 3.724558e-04 | 1 |
| GO:BP | GO:0000018 | regulation of DNA recombination | "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732] | 12 | 3.783157e-04 | 1 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 120 | 3.846938e-04 | 1 |
| GO:BP | GO:0030308 | negative regulation of cell growth | "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] | 13 | 4.190206e-04 | 1 |
| GO:BP | GO:1900180 | regulation of protein localization to nucleus | "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 12 | 4.398767e-04 | 1 |
| GO:BP | GO:0034101 | erythrocyte homeostasis | "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] | 12 | 4.738827e-04 | 1 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] | 22 | 5.155715e-04 | 1 |
| GO:BP | GO:0065004 | protein-DNA complex assembly | "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] | 15 | 5.305908e-04 | 1 |
| GO:BP | GO:0051783 | regulation of nuclear division | "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] | 12 | 5.490002e-04 | 1 |
| GO:BP | GO:2001251 | negative regulation of chromosome organization | "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol] | 10 | 5.533696e-04 | 1 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 9 | 5.927747e-04 | 1 |
| GO:BP | GO:0044092 | negative regulation of molecular function | "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 23 | 5.967701e-04 | 1 |
| GO:BP | GO:0070647 | protein modification by small protein conjugation or removal | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] | 32 | 6.139759e-04 | 1 |
| GO:BP | GO:0030097 | hemopoiesis | "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] | 32 | 6.280449e-04 | 1 |
| GO:BP | GO:0036293 | response to decreased oxygen levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] | 17 | 6.751115e-04 | 1 |
| GO:BP | GO:0050000 | chromosome localization | "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai] | 11 | 7.696850e-04 | 1 |
| GO:BP | GO:0007062 | sister chromatid cohesion | "The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other." [GOC:jh, GOC:mah, ISBN:0815316194] | 8 | 7.976933e-04 | 1 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb] | 17 | 8.052900e-04 | 1 |
| GO:BP | GO:0045911 | positive regulation of DNA recombination | "Any process that activates or increases the frequency, rate or extent of DNA recombination." [GOC:go_curators] | 9 | 8.339191e-04 | 1 |
| GO:BP | GO:0031145 | anaphase-promoting complex-dependent catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442] | 6 | 8.422001e-04 | 1 |
| GO:BP | GO:0006287 | base-excision repair, gap-filling | "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131] | 5 | 8.883017e-04 | 1 |
| GO:BP | GO:0050673 | epithelial cell proliferation | "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] | 20 | 9.519733e-04 | 1 |
| GO:BP | GO:0007178 | cell surface receptor protein serine/threonine kinase signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] | 18 | 1.044203e-03 | 1 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 34 | 1.124499e-03 | 1 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 121 | 1.153161e-03 | 1 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 14 | 1.268670e-03 | 1 |
| GO:BP | GO:0048872 | homeostasis of number of cells | "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete] | 17 | 1.344369e-03 | 1 |
| GO:BP | GO:1902808 | positive regulation of cell cycle G1/S phase transition | "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 8 | 1.363402e-03 | 1 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 64 | 1.363660e-03 | 1 |
| GO:BP | GO:0016233 | telomere capping | "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055] | 6 | 1.379334e-03 | 1 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 25 | 1.385387e-03 | 1 |
| GO:BP | GO:0006289 | nucleotide-excision repair | "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] | 9 | 1.425920e-03 | 1 |
| GO:BP | GO:0007052 | mitotic spindle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah] | 11 | 1.430056e-03 | 1 |
| GO:BP | GO:1905168 | positive regulation of double-strand break repair via homologous recombination | "Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299] | 7 | 1.517523e-03 | 1 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575] | 15 | 1.537185e-03 | 1 |
| GO:BP | GO:0051225 | spindle assembly | "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] | 11 | 1.658232e-03 | 1 |
| GO:BP | GO:0010720 | positive regulation of cell development | "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] | 20 | 1.716880e-03 | 1 |
| GO:BP | GO:0000731 | DNA synthesis involved in DNA repair | "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855] | 7 | 1.786078e-03 | 1 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 150 | 1.894689e-03 | 1 |
| GO:BP | GO:1902850 | microtubule cytoskeleton organization involved in mitosis | "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626] | 12 | 2.123625e-03 | 1 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:mah] | 15 | 2.140461e-03 | 1 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:22651914, PMID:28096268] | 17 | 2.192534e-03 | 1 |
| GO:BP | GO:0043525 | positive regulation of neuron apoptotic process | "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] | 8 | 2.241218e-03 | 1 |
| GO:BP | GO:0006284 | base-excision repair | "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] | 7 | 2.443727e-03 | 1 |
| GO:BP | GO:0023052 | signaling | "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] | 115 | 2.600668e-03 | 1 |
| GO:BP | GO:0007000 | nucleolus organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] | 5 | 2.665030e-03 | 1 |
| GO:BP | GO:0007165 | signal transduction | "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] | 108 | 2.841469e-03 | 1 |
| GO:BP | GO:0007154 | cell communication | "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] | 115 | 3.201693e-03 | 1 |
| GO:BP | GO:0045732 | positive regulation of protein catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] | 13 | 3.374654e-03 | 1 |
| GO:BP | GO:0071163 | DNA replication preinitiation complex assembly | "The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins as part of initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity." [GOC:mah, PMID:28209641] | 3 | 3.390651e-03 | 1 |
| GO:BP | GO:0110032 | positive regulation of G2/MI transition of meiotic cell cycle | "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw, PMID:25492408] | 3 | 3.390651e-03 | 1 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 9 | 3.428009e-03 | 1 |
| GO:BP | GO:0051303 | establishment of chromosome localization | "The directed movement of a chromosome to a specific location." [GOC:ai] | 10 | 3.432380e-03 | 1 |
| GO:BP | GO:0007623 | circadian rhythm | "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] | 13 | 3.559025e-03 | 1 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 29 | 3.864734e-03 | 1 |
| GO:BP | GO:1905820 | positive regulation of chromosome separation | "Any process that activates or increases the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393] | 6 | 4.013405e-03 | 1 |
| GO:BP | GO:0007088 | regulation of mitotic nuclear division | "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] | 10 | 4.316859e-03 | 1 |
| GO:BP | GO:0002262 | myeloid cell homeostasis | "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] | 12 | 4.371982e-03 | 1 |
| GO:BP | GO:0071482 | cellular response to light stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah] | 10 | 4.652760e-03 | 1 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] | 17 | 4.724605e-03 | 1 |
| GO:BP | GO:0000183 | rDNA heterochromatin formation | "The formation of heterochromatin at ribosomal DNA, characterized by the modified histone H3K9me3." [PMID:10219245] | 4 | 4.881275e-03 | 1 |
| GO:BP | GO:0045132 | meiotic chromosome segregation | "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah] | 9 | 4.905106e-03 | 1 |
| GO:BP | GO:1904030 | negative regulation of cyclin-dependent protein kinase activity | "Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] | 5 | 4.909448e-03 | 1 |
| GO:BP | GO:0070848 | response to growth factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah] | 25 | 5.035120e-03 | 1 |
| GO:BP | GO:0031023 | microtubule organizing center organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] | 11 | 5.299854e-03 | 1 |
| GO:BP | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | "The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783] | 9 | 5.350170e-03 | 1 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 8 | 5.490561e-03 | 1 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 74 | 5.628029e-03 | 1 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 31 | 5.845666e-03 | 1 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] | 44 | 6.130062e-03 | 1 |
| GO:BP | GO:0032501 | multicellular organismal process | "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] | 124 | 6.764434e-03 | 1 |
| GO:BP | GO:0044784 | metaphase/anaphase transition of cell cycle | "The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle." [GOC:mtg_cell_cycle] | 9 | 6.899976e-03 | 1 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | "The alteration of an amino acid residue in a peptide." [GOC:mah] | 24 | 6.927574e-03 | 1 |
| GO:BP | GO:0008608 | attachment of spindle microtubules to kinetochore | "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137] | 7 | 7.444982e-03 | 1 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah] | 24 | 7.461168e-03 | 1 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 8 | 7.464533e-03 | 1 |
| GO:BP | GO:0090307 | mitotic spindle assembly | "Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw] | 8 | 7.464533e-03 | 1 |
| GO:BP | GO:1990700 | nucleolar chromatin organization | "Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin." [PMID:18362178] | 4 | 8.057891e-03 | 1 |
| GO:BP | GO:0061614 | miRNA transcription | "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799] | 8 | 8.243550e-03 | 1 |
| GO:BP | GO:1905818 | regulation of chromosome separation | "Any process that modulates the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393] | 8 | 8.243550e-03 | 1 |
| GO:BP | GO:0060218 | hematopoietic stem cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083] | 6 | 8.283120e-03 | 1 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 53 | 8.694316e-03 | 1 |
| GO:BP | GO:0034097 | response to cytokine | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] | 29 | 8.964120e-03 | 1 |
| GO:BP | GO:0006473 | protein acetylation | "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] | 7 | 9.550358e-03 | 1 |
| GO:BP | GO:0051099 | positive regulation of binding | "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] | 9 | 9.555346e-03 | 1 |
| GO:BP | GO:0051310 | metaphase chromosome alignment | "A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [GOC:vw] | 9 | 9.555346e-03 | 1 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 24 | 9.992573e-03 | 1 |
| GO:BP | GO:0007417 | central nervous system development | "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] | 31 | 1.065430e-02 | 1 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 7 | 1.077573e-02 | 1 |
| GO:BP | GO:0033047 | regulation of mitotic sister chromatid segregation | "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] | 7 | 1.077573e-02 | 1 |
| GO:BP | GO:0070199 | establishment of protein localization to chromosome | "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] | 5 | 1.079236e-02 | 1 |
| GO:BP | GO:0071453 | cellular response to oxygen levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah] | 11 | 1.100112e-02 | 1 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 28 | 1.138808e-02 | 1 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 30 | 1.174591e-02 | 1 |
| GO:BP | GO:0060395 | SMAD protein signal transduction | "An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes." [GOC:BHF] | 8 | 1.208604e-02 | 1 |
| GO:BP | GO:1901652 | response to peptide | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] | 29 | 1.211733e-02 | 1 |
| GO:BP | GO:0072594 | establishment of protein localization to organelle | "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] | 23 | 1.218421e-02 | 1 |
| GO:BP | GO:0045814 | negative regulation of gene expression, epigenetic | "An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696] | 12 | 1.226008e-02 | 1 |
| GO:BP | GO:0002376 | immune system process | "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] | 61 | 1.230711e-02 | 1 |
| GO:BP | GO:0071902 | positive regulation of protein serine/threonine kinase activity | "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] | 10 | 1.237362e-02 | 1 |
| GO:BP | GO:0071481 | cellular response to X-ray | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah] | 4 | 1.254171e-02 | 1 |
| GO:BP | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore | "Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] | 4 | 1.254171e-02 | 1 |
| GO:BP | GO:1901995 | positive regulation of meiotic cell cycle phase transition | "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 3 | 1.344067e-02 | 1 |
| GO:BP | GO:0018076 | N-terminal peptidyl-lysine acetylation | "The acetylation of the N-terminal lysine of proteins." [GOC:ai] | 3 | 1.344067e-02 | 1 |
| GO:BP | GO:0031860 | telomeric 3' overhang formation | "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans." [PMID:16096639] | 3 | 1.344067e-02 | 1 |
| GO:BP | GO:0031099 | regeneration | "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass)." [GOC:mah, GOC:pr] | 12 | 1.356930e-02 | 1 |
| GO:BP | GO:0090042 | tubulin deacetylation | "The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:BHF, GOC:dph, GOC:tb] | 5 | 1.365415e-02 | 1 |
| GO:BP | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore | "Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] | 5 | 1.365415e-02 | 1 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 70 | 1.367212e-02 | 1 |
| GO:BP | GO:0002520 | immune system development | "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] | 12 | 1.426877e-02 | 1 |
| GO:BP | GO:2000241 | regulation of reproductive process | "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] | 12 | 1.426877e-02 | 1 |
| GO:BP | GO:0045860 | positive regulation of protein kinase activity | "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] | 13 | 1.469487e-02 | 1 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 70 | 1.481639e-02 | 1 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 7 | 1.526157e-02 | 1 |
| GO:BP | GO:0006367 | transcription initiation at RNA polymerase II promoter | "A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH] | 11 | 1.547650e-02 | 1 |
| GO:BP | GO:0051304 | chromosome separation | "The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II)." [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243] | 8 | 1.587697e-02 | 1 |
| GO:BP | GO:0018205 | peptidyl-lysine modification | "The modification of peptidyl-lysine." [GOC:go_curators] | 10 | 1.600724e-02 | 1 |
| GO:BP | GO:0007098 | centrosome cycle | "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] | 10 | 1.600724e-02 | 1 |
| GO:BP | GO:0006979 | response to oxidative stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] | 17 | 1.649477e-02 | 1 |
| GO:BP | GO:0030099 | myeloid cell differentiation | "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149] | 18 | 1.652218e-02 | 1 |
| GO:BP | GO:0007051 | spindle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah] | 12 | 1.656067e-02 | 1 |
| GO:BP | GO:0000209 | protein polyubiquitination | "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [PMID:26906419] | 14 | 1.720863e-02 | 1 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906] | 20 | 1.732872e-02 | 1 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 63 | 1.739337e-02 | 1 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 23 | 1.793972e-02 | 1 |
| GO:BP | GO:0033002 | muscle cell proliferation | "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah] | 12 | 1.826230e-02 | 1 |
| GO:BP | GO:1901993 | regulation of meiotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 1.863334e-02 | 1 |
| GO:BP | GO:0048659 | smooth muscle cell proliferation | "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698] | 10 | 1.930566e-02 | 1 |
| GO:BP | GO:0001558 | regulation of cell growth | "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] | 17 | 2.001975e-02 | 1 |
| GO:BP | GO:0006476 | protein deacetylation | "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] | 6 | 2.099059e-02 | 1 |
| GO:BP | GO:0006312 | mitotic recombination | "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles." [GOC:elh] | 5 | 2.113593e-02 | 1 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 7 | 2.119791e-02 | 1 |
| GO:BP | GO:0002065 | columnar/cuboidal epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] | 9 | 2.178641e-02 | 1 |
| GO:BP | GO:0035295 | tube development | "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] | 31 | 2.220040e-02 | 1 |
| GO:BP | GO:0007399 | nervous system development | "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] | 56 | 2.322987e-02 | 1 |
| GO:BP | GO:2000378 | negative regulation of reactive oxygen species metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] | 6 | 2.414838e-02 | 1 |
| GO:BP | GO:0006997 | nucleus organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] | 10 | 2.460482e-02 | 1 |
| GO:BP | GO:0019985 | translesion synthesis | "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901] | 5 | 2.591025e-02 | 1 |
| GO:BP | GO:0070198 | protein localization to chromosome, telomeric region | "Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome." [GOC:BHF, GOC:mah] | 5 | 2.591025e-02 | 1 |
| GO:BP | GO:0008156 | negative regulation of DNA replication | "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators] | 5 | 2.591025e-02 | 1 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 7 | 2.612989e-02 | 1 |
| GO:BP | GO:0030225 | macrophage differentiation | "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149] | 7 | 2.612989e-02 | 1 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 8 | 2.651976e-02 | 1 |
| GO:BP | GO:0031571 | mitotic G1 DNA damage checkpoint signaling | "A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle] | 4 | 2.665848e-02 | 1 |
| GO:BP | GO:0070192 | chromosome organization involved in meiotic cell cycle | "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah] | 7 | 2.893061e-02 | 1 |
| GO:BP | GO:0009607 | response to biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] | 40 | 3.050896e-02 | 1 |
| GO:BP | GO:0031507 | heterochromatin formation | "An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation." [PMID:25192661, PMID:33827924] | 10 | 3.111239e-02 | 1 |
| GO:BP | GO:0001756 | somitogenesis | "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] | 7 | 3.197495e-02 | 1 |
| GO:BP | GO:1902292 | cell cycle DNA replication initiation | "Any DNA replication initiation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 3.329977e-02 | 1 |
| GO:BP | GO:1902975 | mitotic DNA replication initiation | "Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] | 3 | 3.329977e-02 | 1 |
| GO:BP | GO:0070345 | negative regulation of fat cell proliferation | "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] | 3 | 3.329977e-02 | 1 |
| GO:BP | GO:0043550 | regulation of lipid kinase activity | "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf] | 3 | 3.329977e-02 | 1 |
| GO:BP | GO:1902315 | nuclear cell cycle DNA replication initiation | "Any DNA replication initiation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 3.329977e-02 | 1 |
| GO:BP | GO:1905784 | regulation of anaphase-promoting complex-dependent catabolic process | "Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876] | 3 | 3.329977e-02 | 1 |
| GO:BP | GO:0030071 | regulation of mitotic metaphase/anaphase transition | "Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mah] | 8 | 3.377053e-02 | 1 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 16 | 3.414635e-02 | 1 |
| GO:BP | GO:0060322 | head development | "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph] | 25 | 3.418501e-02 | 1 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 58 | 3.457438e-02 | 1 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 32 | 3.471636e-02 | 1 |
| GO:BP | GO:0035825 | homologous recombination | "A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules." [GOC:mah, PMID:11139492, PMID:17304215] | 7 | 3.527916e-02 | 1 |
| GO:BP | GO:2000105 | positive regulation of DNA-templated DNA replication | "Any process that activates or increases the frequency, rate or extent of DNA-templated DNA replication." [GOC:mah] | 4 | 3.696655e-02 | 1 |
| GO:BP | GO:0140718 | facultative heterochromatin formation | "The compaction of chromatin into a conformation that is refractory to transcription but that can be converted to euchromatin and allow transcription in specific contexts. These can be temporal (e.g., developmental states or specific cell-cycle stages), spatial (e.g., nuclear localization changes from the center to the periphery or vice versa due to exogenous factors/signals), or parental/heritable (e.g., monoallelic gene expression). In metazoa, this involves the methylation of histone H3K27." [PMID:17936700] | 4 | 3.696655e-02 | 1 |
| GO:BP | GO:0051177 | meiotic sister chromatid cohesion | "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai] | 4 | 3.696655e-02 | 1 |
| GO:BP | GO:0090235 | regulation of metaphase plate congression | "Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] | 4 | 3.696655e-02 | 1 |
| GO:BP | GO:0044819 | mitotic G1/S transition checkpoint signaling | "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] | 4 | 3.696655e-02 | 1 |
| GO:BP | GO:0022008 | neurogenesis | "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] | 42 | 3.870585e-02 | 1 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 36 | 3.925799e-02 | 1 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 58 | 3.928975e-02 | 1 |
| GO:BP | GO:1900182 | positive regulation of protein localization to nucleus | "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 8 | 3.947565e-02 | 1 |
| GO:BP | GO:1902099 | regulation of metaphase/anaphase transition of cell cycle | "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] | 8 | 4.261842e-02 | 1 |
| GO:BP | GO:0010563 | negative regulation of phosphorus metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 14 | 4.320516e-02 | 1 |
| GO:BP | GO:0045936 | negative regulation of phosphate metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 14 | 4.320516e-02 | 1 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 162 | 4.345502e-02 | 1 |
| GO:BP | GO:0016567 | protein ubiquitination | "The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419] | 24 | 4.494901e-02 | 1 |
| GO:BP | GO:0098534 | centriole assembly | "A cellular process that results in the assembly of one or more centrioles." [GOC:dos, PMID:24075808] | 6 | 4.620671e-02 | 1 |
| GO:BP | GO:1901976 | regulation of cell cycle checkpoint | "Any process that modulates the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116] | 6 | 4.620671e-02 | 1 |
| GO:BP | GO:0006360 | transcription by RNA polymerase I | "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] | 7 | 4.692491e-02 | 1 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] | 40 | 4.820683e-02 | 1 |
| GO:BP | GO:0044027 | negative regulation of gene expression via chromosomal CpG island methylation | "An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide associated with the transcription start site of genes." [PMID:11898023, Wikipedia:Cpg_island] | 4 | 4.992920e-02 | 1 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP179 | Cell cycle | Cell cycle | 61 | 2.132895e-67 | 1 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 40 | 3.814763e-40 | 1 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 35 | 8.348067e-39 | 1 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 30 | 3.964833e-28 | 1 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 29 | 1.757065e-27 | 1 |
| WP | WP:WP466 | DNA replication | DNA replication | 20 | 7.198061e-20 | 1 |
| WP | WP:WP4016 | DNA IR damage and cellular response via ATR | DNA IR damage and cellular response via ATR | 24 | 3.186239e-18 | 1 |
| WP | WP:WP1971 | Integrated cancer pathway | Integrated cancer pathway | 19 | 8.654954e-18 | 1 |
| WP | WP:WP3959 | DNA IR double strand breaks and cellular response via ATM | DNA IR double strand breaks and cellular response via ATM | 19 | 1.374388e-15 | 1 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 24 | 1.570622e-14 | 1 |
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 24 | 5.549870e-14 | 1 |
| WP | WP:WP5180 | DYRK1A involvement regarding cell proliferation in brain development | DYRK1A involvement regarding cell proliferation in brain development | 18 | 3.561147e-13 | 1 |
| WP | WP:WP1984 | Integrated breast cancer pathway | Integrated breast cancer pathway | 25 | 1.962697e-12 | 1 |
| WP | WP:WP2516 | ATM signaling | ATM signaling | 14 | 8.005357e-12 | 1 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 18 | 1.082332e-09 | 1 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 16 | 1.079475e-08 | 1 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 38 | 2.200405e-08 | 1 |
| WP | WP:WP3878 | ATM signaling in development and disease | ATM signaling in development and disease | 12 | 1.090711e-07 | 1 |
| WP | WP:WP53 | ID signaling | ID signaling | 8 | 1.846126e-07 | 1 |
| WP | WP:WP5114 | Nucleotide excision repair in xeroderma pigmentosum | Nucleotide excision repair in xeroderma pigmentosum | 13 | 2.827556e-06 | 1 |
| WP | WP:WP531 | DNA mismatch repair | DNA mismatch repair | 8 | 6.101710e-06 | 1 |
| WP | WP:WP4753 | Nucleotide excision repair | Nucleotide excision repair | 10 | 8.374798e-06 | 1 |
| WP | WP:WP236 | Adipogenesis | Adipogenesis | 16 | 1.161785e-05 | 1 |
| WP | WP:WP5118 | SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome | SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome | 6 | 1.357250e-05 | 1 |
| WP | WP:WP4879 | Overlap between signal transduction pathways contributing to LMNA laminopathies | Overlap between signal transduction pathways contributing to LMNA laminopathies | 11 | 1.378454e-05 | 1 |
| WP | WP:WP138 | Androgen receptor signaling | Androgen receptor signaling | 13 | 1.589499e-05 | 1 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 12 | 2.242020e-05 | 1 |
| WP | WP:WP4262 | Breast cancer pathway | Breast cancer pathway | 17 | 2.242862e-05 | 1 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 13 | 2.427579e-05 | 1 |
| WP | WP:WP186 | Homologous recombination | Homologous recombination | 6 | 4.845870e-05 | 1 |
| WP | WP:WP2431 | Spinal cord injury | Spinal cord injury | 14 | 9.264662e-05 | 1 |
| WP | WP:WP5158 | Urotensin II mediated signaling | Urotensin II mediated signaling | 11 | 1.064075e-04 | 1 |
| WP | WP:WP3646 | Hepatitis C and hepatocellular carcinoma | Hepatitis C and hepatocellular carcinoma | 10 | 1.191014e-04 | 1 |
| WP | WP:WP2586 | Aryl hydrocarbon receptor pathway | Aryl hydrocarbon receptor pathway | 9 | 1.975997e-04 | 1 |
| WP | WP:WP3611 | Photodynamic therapy induced AP 1 survival signaling | Photodynamic therapy induced AP 1 survival signaling | 9 | 4.141664e-04 | 1 |
| WP | WP:WP3391 | Senescence associated secretory phenotype SASP | Senescence associated secretory phenotype SASP | 13 | 4.180723e-04 | 1 |
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 13 | 4.180723e-04 | 1 |
| WP | WP:WP5497 | Cyclin dependent kinase 4 6 inhibitors in breast cancer | Cyclin dependent kinase 4 6 inhibitors in breast cancer | 8 | 4.490991e-04 | 1 |
| WP | WP:WP4963 | p53 transcriptional gene network | p53 transcriptional gene network | 12 | 4.737170e-04 | 1 |
| WP | WP:WP2361 | Gastric cancer network 1 | Gastric cancer network 1 | 7 | 5.761820e-04 | 1 |
| WP | WP:WP5144 | NRP1 triggered signaling in pancreatic cancer | NRP1 triggered signaling in pancreatic cancer | 9 | 6.891257e-04 | 1 |
| WP | WP:WP4630 | Measles virus infection | Measles virus infection | 14 | 7.159847e-04 | 1 |
| WP | WP:WP3657 | Hematopoietic stem cell gene regulation by GABP alpha beta complex | Hematopoietic stem cell gene regulation by GABP alpha beta complex | 6 | 9.533589e-04 | 1 |
| WP | WP:WP4752 | Base excision repair | Base excision repair | 7 | 1.205068e-03 | 1 |
| WP | WP:WP4255 | Non small cell lung cancer | Non small cell lung cancer | 10 | 1.292059e-03 | 1 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 10 | 1.661610e-03 | 1 |
| WP | WP:WP5103 | Progeria associated lipodystrophy | Progeria associated lipodystrophy | 6 | 1.764314e-03 | 1 |
| WP | WP:WP4685 | Melanoma | Melanoma | 9 | 5.646831e-03 | 1 |
| WP | WP:WP1545 | miRNAs involved in DNA damage response | miRNAs involved in DNA damage response | 9 | 5.646831e-03 | 1 |
| WP | WP:WP4767 | FGFR3 signaling in chondrocyte proliferation and terminal differentiation | FGFR3 signaling in chondrocyte proliferation and terminal differentiation | 6 | 6.343689e-03 | 1 |
| WP | WP:WP615 | Senescence and autophagy in cancer | Senescence and autophagy in cancer | 11 | 6.932444e-03 | 1 |
| WP | WP:WP2828 | Bladder cancer | Bladder cancer | 7 | 7.137972e-03 | 1 |
| WP | WP:WP4673 | Male infertility | Male infertility | 13 | 7.189473e-03 | 1 |
| WP | WP:WP5527 | NF kB signaling and ARTD family members | NF kB signaling and ARTD family members | 6 | 7.916646e-03 | 1 |
| WP | WP:WP4172 | PI3K Akt signaling | PI3K Akt signaling | 21 | 8.280506e-03 | 1 |
| WP | WP:WP405 | Eukaryotic transcription initiation | Eukaryotic transcription initiation | 7 | 8.437537e-03 | 1 |
| WP | WP:WP710 | DNA damage response only ATM dependent | DNA damage response only ATM dependent | 11 | 9.834822e-03 | 1 |
| WP | WP:WP438 | Non homologous end joining | Non homologous end joining | 4 | 1.147927e-02 | 1 |
| WP | WP:WP2032 | Thyroid stimulating hormone TSH signaling | Thyroid stimulating hormone TSH signaling | 8 | 1.175415e-02 | 1 |
| WP | WP:WP5300 | TROP2 regulatory signaling | TROP2 regulatory signaling | 7 | 1.354677e-02 | 1 |
| WP | WP:WP3981 | miRNA regulation of prostate cancer signaling | miRNA regulation of prostate cancer signaling | 6 | 1.458658e-02 | 1 |
| WP | WP:WP5465 | Fanconi anemia | Fanconi anemia | 7 | 2.094302e-02 | 1 |
| WP | WP:WP5046 | NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence | NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence | 5 | 2.678852e-02 | 1 |
| WP | WP:WP4211 | Transcriptional cascade regulating adipogenesis | Transcriptional cascade regulating adipogenesis | 4 | 3.696821e-02 | 1 |
| WP | WP:WP5366 | NF1 copy number variation syndrome | NF1 copy number variation syndrome | 10 | 4.140500e-02 | 1 |
| WP | WP:WP5087 | Pleural mesothelioma | Pleural mesothelioma | 23 | 4.538469e-02 | 1 |
| WP | WP:WP4399 | MicroRNA network associated with chronic lymphocytic leukemia | MicroRNA network associated with chronic lymphocytic leukemia | 3 | 4.998517e-02 | 1 |
| WP | WP:WP3672 | lncRNA mediated mechanisms of therapeutic resistance | lncRNA mediated mechanisms of therapeutic resistance | 3 | 4.998517e-02 | 1 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 64 | 1.462188e-66 | 1 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 35 | 1.154612e-24 | 1 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | Progesterone-mediated oocyte maturation | 23 | 1.007696e-15 | 1 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 30 | 1.762674e-14 | 1 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 24 | 3.062869e-14 | 1 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 27 | 1.221402e-12 | 1 |
| KEGG | KEGG:04115 | p53 signaling pathway | p53 signaling pathway | 17 | 1.625061e-11 | 1 |
| KEGG | KEGG:03030 | DNA replication | DNA replication | 13 | 2.009176e-11 | 1 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 39 | 4.522002e-10 | 1 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 17 | 7.137109e-10 | 1 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 21 | 1.204228e-07 | 1 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 19 | 1.427849e-07 | 1 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 15 | 1.768765e-07 | 1 |
| KEGG | KEGG:04068 | FoxO signaling pathway | FoxO signaling pathway | 17 | 2.289983e-07 | 1 |
| KEGG | KEGG:03450 | Non-homologous end-joining | Non-homologous end-joining | 7 | 2.891882e-07 | 1 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 13 | 6.283840e-07 | 1 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | TGF-beta signaling pathway | 15 | 7.148575e-07 | 1 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | MicroRNAs in cancer | 25 | 9.147521e-07 | 1 |
| KEGG | KEGG:03430 | Mismatch repair | Mismatch repair | 8 | 1.443944e-06 | 1 |
| KEGG | KEGG:03420 | Nucleotide excision repair | Nucleotide excision repair | 11 | 5.429078e-06 | 1 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 12 | 6.248411e-06 | 1 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 16 | 9.692435e-06 | 1 |
| KEGG | KEGG:05219 | Bladder cancer | Bladder cancer | 9 | 1.543303e-05 | 1 |
| KEGG | KEGG:03440 | Homologous recombination | Homologous recombination | 9 | 1.543303e-05 | 1 |
| KEGG | KEGG:03410 | Base excision repair | Base excision repair | 9 | 2.954446e-05 | 1 |
| KEGG | KEGG:01522 | Endocrine resistance | Endocrine resistance | 12 | 7.720609e-05 | 1 |
| KEGG | KEGG:05162 | Measles | Measles | 14 | 1.381499e-04 | 1 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 11 | 1.993871e-04 | 1 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 22 | 2.043948e-04 | 1 |
| KEGG | KEGG:04934 | Cushing syndrome | Cushing syndrome | 14 | 4.739882e-04 | 1 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | Non-small cell lung cancer | 9 | 2.115764e-03 | 1 |
| KEGG | KEGG:05218 | Melanoma | Melanoma | 9 | 2.115764e-03 | 1 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 21 | 2.338280e-03 | 1 |
| KEGG | KEGG:05214 | Glioma | Glioma | 9 | 2.954253e-03 | 1 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 13 | 5.513031e-03 | 1 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | Transcriptional misregulation in cancer | 14 | 6.235509e-03 | 1 |
| KEGG | KEGG:05224 | Breast cancer | Breast cancer | 12 | 7.177542e-03 | 1 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 12 | 1.436776e-02 | 1 |
| KEGG | KEGG:01524 | Platinum drug resistance | Platinum drug resistance | 8 | 1.437018e-02 | 1 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 13 | 2.663016e-02 | 1 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | AGE-RAGE signaling pathway in diabetic complications | 9 | 2.825721e-02 | 1 |
| KEGG | KEGG:03022 | Basal transcription factors | Basal transcription factors | 6 | 2.851180e-02 | 1 |
| KEGG | KEGG:03083 | Polycomb repressive complex | Polycomb repressive complex | 8 | 4.206471e-02 | 1 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 94 | 1.547886e-56 | 1 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 83 | 7.246499e-52 | 1 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 52 | 7.320063e-51 | 1 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 52 | 1.804612e-48 | 1 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 45 | 5.409625e-43 | 1 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 28 | 1.778046e-34 | 1 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 28 | 1.778046e-34 | 1 |
| REAC | REAC:R-HSA-1538133 | G0 and Early G1 | G0 and Early G1 | 19 | 1.943618e-25 | 1 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 28 | 2.163707e-25 | 1 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 48 | 2.997019e-25 | 1 |
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 21 | 4.209969e-25 | 1 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 92 | 1.063027e-24 | 1 |
| REAC | REAC:R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 16 | 1.071595e-24 | 1 |
| REAC | REAC:R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 16 | 1.071595e-24 | 1 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 83 | 1.121263e-24 | 1 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 21 | 2.106336e-24 | 1 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 30 | 4.895221e-23 | 1 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 18 | 7.787072e-23 | 1 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 26 | 8.614195e-23 | 1 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 84 | 1.450351e-22 | 1 |
| REAC | REAC:R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | TP53 Regulates Transcription of Cell Cycle Genes | 21 | 2.388316e-21 | 1 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 33 | 1.819300e-20 | 1 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 39 | 3.876672e-20 | 1 |
| REAC | REAC:R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | Cyclin A/B1/B2 associated events during G2/M transition | 16 | 2.886253e-19 | 1 |
| REAC | REAC:R-HSA-73894 | DNA Repair | DNA Repair | 39 | 4.621732e-18 | 1 |
| REAC | REAC:R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 12 | 2.888153e-16 | 1 |
| REAC | REAC:R-HSA-68962 | Activation of the pre-replicative complex | Activation of the pre-replicative complex | 15 | 2.825649e-15 | 1 |
| REAC | REAC:R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 12 | 1.121424e-14 | 1 |
| REAC | REAC:R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | Transcription of E2F targets under negative control by DREAM complex | 12 | 1.121424e-14 | 1 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 26 | 2.595987e-14 | 1 |
| REAC | REAC:R-HSA-5693532 | DNA Double-Strand Break Repair | DNA Double-Strand Break Repair | 26 | 4.082421e-14 | 1 |
| REAC | REAC:R-HSA-156711 | Polo-like kinase mediated events | Polo-like kinase mediated events | 11 | 4.780664e-14 | 1 |
| REAC | REAC:R-HSA-69190 | DNA strand elongation | DNA strand elongation | 14 | 7.312434e-14 | 1 |
| REAC | REAC:R-HSA-5633007 | Regulation of TP53 Activity | Regulation of TP53 Activity | 25 | 9.841220e-14 | 1 |
| REAC | REAC:R-HSA-2559583 | Cellular Senescence | Cellular Senescence | 27 | 1.174429e-13 | 1 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 20 | 1.456547e-13 | 1 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 27 | 1.988889e-13 | 1 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 83 | 3.116040e-13 | 1 |
| REAC | REAC:R-HSA-176187 | Activation of ATR in response to replication stress | Activation of ATR in response to replication stress | 14 | 8.721279e-13 | 1 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 51 | 2.784817e-12 | 1 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 50 | 6.051317e-12 | 1 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 25 | 1.282105e-11 | 1 |
| REAC | REAC:R-HSA-113510 | E2F mediated regulation of DNA replication | E2F mediated regulation of DNA replication | 11 | 4.150675e-11 | 1 |
| REAC | REAC:R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 14 | 1.080310e-10 | 1 |
| REAC | REAC:R-HSA-180786 | Extension of Telomeres | Extension of Telomeres | 14 | 1.464663e-10 | 1 |
| REAC | REAC:R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 9 | 2.138889e-10 | 1 |
| REAC | REAC:R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Regulation of TP53 Activity through Phosphorylation | 17 | 4.559559e-10 | 1 |
| REAC | REAC:R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 12 | 5.617584e-10 | 1 |
| REAC | REAC:R-HSA-2559585 | Oncogene Induced Senescence | Oncogene Induced Senescence | 11 | 5.039127e-09 | 1 |
| REAC | REAC:R-HSA-5693538 | Homology Directed Repair | Homology Directed Repair | 19 | 6.202699e-09 | 1 |
| REAC | REAC:R-HSA-69002 | DNA Replication Pre-Initiation | DNA Replication Pre-Initiation | 20 | 7.310178e-09 | 1 |
| REAC | REAC:R-HSA-69186 | Lagging Strand Synthesis | Lagging Strand Synthesis | 9 | 1.626968e-08 | 1 |
| REAC | REAC:R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | Global Genome Nucleotide Excision Repair (GG-NER) | 15 | 1.736899e-08 | 1 |
| REAC | REAC:R-HSA-5696398 | Nucleotide Excision Repair | Nucleotide Excision Repair | 16 | 6.182752e-08 | 1 |
| REAC | REAC:R-HSA-170834 | Signaling by TGF-beta Receptor Complex | Signaling by TGF-beta Receptor Complex | 15 | 6.731337e-08 | 1 |
| REAC | REAC:R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | DNA Damage/Telomere Stress Induced Senescence | 14 | 8.873666e-08 | 1 |
| REAC | REAC:R-HSA-9614085 | FOXO-mediated transcription | FOXO-mediated transcription | 13 | 1.007866e-07 | 1 |
| REAC | REAC:R-HSA-5685942 | HDR through Homologous Recombination (HRR) | HDR through Homologous Recombination (HRR) | 13 | 2.189856e-07 | 1 |
| REAC | REAC:R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 17 | 2.281628e-07 | 1 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 13 | 2.636765e-07 | 1 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 14 | 3.953022e-07 | 1 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 14 | 3.953022e-07 | 1 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 12 | 4.226758e-07 | 1 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 24 | 8.030435e-07 | 1 |
| REAC | REAC:R-HSA-68911 | G2 Phase | G2 Phase | 5 | 1.049411e-06 | 1 |
| REAC | REAC:R-HSA-69478 | G2/M DNA replication checkpoint | G2/M DNA replication checkpoint | 5 | 1.049411e-06 | 1 |
| REAC | REAC:R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | Drug-mediated inhibition of CDK4/CDK6 activity | 5 | 1.049411e-06 | 1 |
| REAC | REAC:R-HSA-69109 | Leading Strand Synthesis | Leading Strand Synthesis | 7 | 1.080520e-06 | 1 |
| REAC | REAC:R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 7 | 1.080520e-06 | 1 |
| REAC | REAC:R-HSA-69091 | Polymerase switching | Polymerase switching | 7 | 1.080520e-06 | 1 |
| REAC | REAC:R-HSA-69183 | Processive synthesis on the lagging strand | Processive synthesis on the lagging strand | 7 | 1.993775e-06 | 1 |
| REAC | REAC:R-HSA-9006936 | Signaling by TGFB family members | Signaling by TGFB family members | 15 | 3.851799e-06 | 1 |
| REAC | REAC:R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | Telomere C-strand (Lagging Strand) Synthesis | 9 | 4.043274e-06 | 1 |
| REAC | REAC:R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 8 | 5.260493e-06 | 1 |
| REAC | REAC:R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 12 | 6.161463e-06 | 1 |
| REAC | REAC:R-HSA-8849470 | PTK6 Regulates Cell Cycle | PTK6 Regulates Cell Cycle | 5 | 6.200103e-06 | 1 |
| REAC | REAC:R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | Gap-filling DNA repair synthesis and ligation in TC-NER | 11 | 6.866755e-06 | 1 |
| REAC | REAC:R-HSA-157579 | Telomere Maintenance | Telomere Maintenance | 14 | 8.833735e-06 | 1 |
| REAC | REAC:R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins | SUMO E3 ligases SUMOylate target proteins | 17 | 1.080910e-05 | 1 |
| REAC | REAC:R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | HDR through MMEJ (alt-NHEJ) | 6 | 1.619941e-05 | 1 |
| REAC | REAC:R-HSA-2990846 | SUMOylation | SUMOylation | 17 | 1.803907e-05 | 1 |
| REAC | REAC:R-HSA-73886 | Chromosome Maintenance | Chromosome Maintenance | 15 | 2.091225e-05 | 1 |
| REAC | REAC:R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | PCNA-Dependent Long Patch Base Excision Repair | 7 | 3.272744e-05 | 1 |
| REAC | REAC:R-HSA-69166 | Removal of the Flap Intermediate | Removal of the Flap Intermediate | 6 | 5.101421e-05 | 1 |
| REAC | REAC:R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 6 | 5.101421e-05 | 1 |
| REAC | REAC:R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 6 | 5.101421e-05 | 1 |
| REAC | REAC:R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | 4 | 5.686464e-05 | 1 |
| REAC | REAC:R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | Senescence-Associated Secretory Phenotype (SASP) | 13 | 7.039862e-05 | 1 |
| REAC | REAC:R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | TP53 Regulates Transcription of DNA Repair Genes | 10 | 8.157368e-05 | 1 |
| REAC | REAC:R-HSA-69473 | G2/M DNA damage checkpoint | G2/M DNA damage checkpoint | 12 | 8.234743e-05 | 1 |
| REAC | REAC:R-HSA-5358508 | Mismatch Repair | Mismatch Repair | 6 | 8.369450e-05 | 1 |
| REAC | REAC:R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | Defective Intrinsic Pathway for Apoptosis | 7 | 9.284767e-05 | 1 |
| REAC | REAC:R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | Impaired BRCA2 binding to PALB2 | 7 | 9.284767e-05 | 1 |
| REAC | REAC:R-HSA-6782135 | Dual incision in TC-NER | Dual incision in TC-NER | 10 | 9.568176e-05 | 1 |
| REAC | REAC:R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | Impaired BRCA2 binding to RAD51 | 8 | 9.737891e-05 | 1 |
| REAC | REAC:R-HSA-6804757 | Regulation of TP53 Degradation | Regulation of TP53 Degradation | 8 | 1.231945e-04 | 1 |
| REAC | REAC:R-HSA-73933 | Resolution of Abasic Sites (AP sites) | Resolution of Abasic Sites (AP sites) | 8 | 1.231945e-04 | 1 |
| REAC | REAC:R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | Resolution of D-loop Structures through Holliday Junction Intermediates | 8 | 1.231945e-04 | 1 |
| REAC | REAC:R-HSA-139915 | Activation of PUMA and translocation to mitochondria | Activation of PUMA and translocation to mitochondria | 5 | 1.243194e-04 | 1 |
| REAC | REAC:R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | 7 | 1.269094e-04 | 1 |
| REAC | REAC:R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | 7 | 1.269094e-04 | 1 |
| REAC | REAC:R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 7 | 1.269094e-04 | 1 |
| REAC | REAC:R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 7 | 1.269094e-04 | 1 |
| REAC | REAC:R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | Initiation of Nuclear Envelope (NE) Reformation | 6 | 1.318183e-04 | 1 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 11 | 1.433352e-04 | 1 |
| REAC | REAC:R-HSA-9675135 | Diseases of DNA repair | Diseases of DNA repair | 9 | 1.488190e-04 | 1 |
| REAC | REAC:R-HSA-5693537 | Resolution of D-Loop Structures | Resolution of D-Loop Structures | 8 | 1.546600e-04 | 1 |
| REAC | REAC:R-HSA-6806003 | Regulation of TP53 Expression and Degradation | Regulation of TP53 Expression and Degradation | 8 | 1.546600e-04 | 1 |
| REAC | REAC:R-HSA-174411 | Polymerase switching on the C-strand of the telomere | Polymerase switching on the C-strand of the telomere | 7 | 1.709109e-04 | 1 |
| REAC | REAC:R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | FOXO-mediated transcription of cell cycle genes | 6 | 2.005361e-04 | 1 |
| REAC | REAC:R-HSA-68867 | Assembly of the pre-replicative complex | Assembly of the pre-replicative complex | 14 | 2.018272e-04 | 1 |
| REAC | REAC:R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 7 | 2.270708e-04 | 1 |
| REAC | REAC:R-HSA-111448 | Activation of NOXA and translocation to mitochondria | Activation of NOXA and translocation to mitochondria | 4 | 2.801256e-04 | 1 |
| REAC | REAC:R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | Presynaptic phase of homologous DNA pairing and strand exchange | 8 | 2.934999e-04 | 1 |
| REAC | REAC:R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | Diseases of DNA Double-Strand Break Repair | 8 | 3.588102e-04 | 1 |
| REAC | REAC:R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 8 | 3.588102e-04 | 1 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 10 | 4.618465e-04 | 1 |
| REAC | REAC:R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | Homologous DNA Pairing and Strand Exchange | 8 | 5.272451e-04 | 1 |
| REAC | REAC:R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 6 | 5.990856e-04 | 1 |
| REAC | REAC:R-HSA-176974 | Unwinding of DNA | Unwinding of DNA | 5 | 7.461688e-04 | 1 |
| REAC | REAC:R-HSA-8863678 | Neurodegenerative Diseases | Neurodegenerative Diseases | 6 | 8.256288e-04 | 1 |
| REAC | REAC:R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | 6 | 8.256288e-04 | 1 |
| REAC | REAC:R-HSA-176417 | Phosphorylation of Emi1 | Phosphorylation of Emi1 | 4 | 8.279765e-04 | 1 |
| REAC | REAC:R-HSA-5693548 | Sensing of DNA Double Strand Breaks | Sensing of DNA Double Strand Breaks | 4 | 8.279765e-04 | 1 |
| REAC | REAC:R-HSA-5693607 | Processing of DNA double-strand break ends | Processing of DNA double-strand break ends | 11 | 9.042276e-04 | 1 |
| REAC | REAC:R-HSA-73762 | RNA Polymerase I Transcription Initiation | RNA Polymerase I Transcription Initiation | 8 | 1.071883e-03 | 1 |
| REAC | REAC:R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | Golgi Cisternae Pericentriolar Stack Reorganization | 5 | 1.194015e-03 | 1 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 24 | 1.435343e-03 | 1 |
| REAC | REAC:R-HSA-162594 | Early Phase of HIV Life Cycle | Early Phase of HIV Life Cycle | 5 | 1.829016e-03 | 1 |
| REAC | REAC:R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | RUNX3 regulates CDKN1A transcription | 4 | 1.903454e-03 | 1 |
| REAC | REAC:R-HSA-5689880 | Ub-specific processing proteases | Ub-specific processing proteases | 16 | 1.920073e-03 | 1 |
| REAC | REAC:R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | APC/C:Cdc20 mediated degradation of Cyclin B | 6 | 1.953530e-03 | 1 |
| REAC | REAC:R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | Nonhomologous End-Joining (NHEJ) | 9 | 2.184352e-03 | 1 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 9 | 2.184352e-03 | 1 |
| REAC | REAC:R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | HDR through Single Strand Annealing (SSA) | 7 | 2.244052e-03 | 1 |
| REAC | REAC:R-HSA-9616222 | Transcriptional regulation of granulopoiesis | Transcriptional regulation of granulopoiesis | 10 | 2.365583e-03 | 1 |
| REAC | REAC:R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | Gap-filling DNA repair synthesis and ligation in GG-NER | 6 | 2.530358e-03 | 1 |
| REAC | REAC:R-HSA-1912422 | Pre-NOTCH Expression and Processing | Pre-NOTCH Expression and Processing | 11 | 2.618228e-03 | 1 |
| REAC | REAC:R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 5 | 2.701677e-03 | 1 |
| REAC | REAC:R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 7 | 2.707246e-03 | 1 |
| REAC | REAC:R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | Loss of Function of SMAD4 in Cancer | 3 | 3.066510e-03 | 1 |
| REAC | REAC:R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | SMAD2/3 MH2 Domain Mutants in Cancer | 3 | 3.066510e-03 | 1 |
| REAC | REAC:R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | SMAD4 MH2 Domain Mutants in Cancer | 3 | 3.066510e-03 | 1 |
| REAC | REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | Intrinsic Pathway for Apoptosis | 8 | 3.168068e-03 | 1 |
| REAC | REAC:R-HSA-9614657 | FOXO-mediated transcription of cell death genes | FOXO-mediated transcription of cell death genes | 5 | 3.869795e-03 | 1 |
| REAC | REAC:R-HSA-1834941 | STING mediated induction of host immune responses | STING mediated induction of host immune responses | 5 | 3.869795e-03 | 1 |
| REAC | REAC:R-HSA-1912408 | Pre-NOTCH Transcription and Translation | Pre-NOTCH Transcription and Translation | 10 | 3.929229e-03 | 1 |
| REAC | REAC:R-HSA-5696400 | Dual Incision in GG-NER | Dual Incision in GG-NER | 7 | 4.597489e-03 | 1 |
| REAC | REAC:R-HSA-212165 | Epigenetic regulation of gene expression | Epigenetic regulation of gene expression | 14 | 4.714200e-03 | 1 |
| REAC | REAC:R-HSA-1500620 | Meiosis | Meiosis | 11 | 5.232292e-03 | 1 |
| REAC | REAC:R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | Regulation of RUNX1 Expression and Activity | 5 | 5.398652e-03 | 1 |
| REAC | REAC:R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 6 | 6.373763e-03 | 1 |
| REAC | REAC:R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | E2F-enabled inhibition of pre-replication complex formation | 4 | 6.651979e-03 | 1 |
| REAC | REAC:R-HSA-5693606 | DNA Double Strand Break Response | DNA Double Strand Break Response | 9 | 6.871948e-03 | 1 |
| REAC | REAC:R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | Nuclear Events (kinase and transcription factor activation) | 8 | 7.072919e-03 | 1 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 6 | 7.843155e-03 | 1 |
| REAC | REAC:R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | Recognition of DNA damage by PCNA-containing replication complex | 6 | 7.843155e-03 | 1 |
| REAC | REAC:R-HSA-162587 | HIV Life Cycle | HIV Life Cycle | 12 | 8.414544e-03 | 1 |
| REAC | REAC:R-HSA-9018519 | Estrogen-dependent gene expression | Estrogen-dependent gene expression | 12 | 9.660146e-03 | 1 |
| REAC | REAC:R-HSA-174414 | Processive synthesis on the C-strand of the telomere | Processive synthesis on the C-strand of the telomere | 5 | 9.838013e-03 | 1 |
| REAC | REAC:R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | NOTCH1 Intracellular Domain Regulates Transcription | 7 | 1.010761e-02 | 1 |
| REAC | REAC:R-HSA-9645723 | Diseases of programmed cell death | Diseases of programmed cell death | 10 | 1.074281e-02 | 1 |
| REAC | REAC:R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | Regulation of FOXO transcriptional activity by acetylation | 4 | 1.092341e-02 | 1 |
| REAC | REAC:R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | Cytosolic sensors of pathogen-associated DNA | 8 | 1.147255e-02 | 1 |
| REAC | REAC:R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | Nuclear events stimulated by ALK signaling in cancer | 6 | 1.160018e-02 | 1 |
| REAC | REAC:R-HSA-68882 | Mitotic Anaphase | Mitotic Anaphase | 15 | 1.211169e-02 | 1 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 21 | 1.241533e-02 | 1 |
| REAC | REAC:R-HSA-2555396 | Mitotic Metaphase and Anaphase | Mitotic Metaphase and Anaphase | 15 | 1.274820e-02 | 1 |
| REAC | REAC:R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 5 | 1.291766e-02 | 1 |
| REAC | REAC:R-HSA-176412 | Phosphorylation of the APC/C | Phosphorylation of the APC/C | 5 | 1.291766e-02 | 1 |
| REAC | REAC:R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | NOTCH4 Intracellular Domain Regulates Transcription | 5 | 1.291766e-02 | 1 |
| REAC | REAC:R-HSA-157118 | Signaling by NOTCH | Signaling by NOTCH | 15 | 1.411047e-02 | 1 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 8 | 1.441587e-02 | 1 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 8 | 1.441587e-02 | 1 |
| REAC | REAC:R-HSA-8878171 | Transcriptional regulation by RUNX1 | Transcriptional regulation by RUNX1 | 15 | 1.639493e-02 | 1 |
| REAC | REAC:R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | NFE2L2 regulating tumorigenic genes | 4 | 1.691277e-02 | 1 |
| REAC | REAC:R-HSA-2514853 | Condensation of Prometaphase Chromosomes | Condensation of Prometaphase Chromosomes | 4 | 1.691277e-02 | 1 |
| REAC | REAC:R-HSA-9700206 | Signaling by ALK in cancer | Signaling by ALK in cancer | 9 | 2.003906e-02 | 1 |
| REAC | REAC:R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | Signaling by ALK fusions and activated point mutants | 9 | 2.003906e-02 | 1 |
| REAC | REAC:R-HSA-9730414 | MITF-M-regulated melanocyte development | MITF-M-regulated melanocyte development | 10 | 2.225395e-02 | 1 |
| REAC | REAC:R-HSA-3247509 | Chromatin modifying enzymes | Chromatin modifying enzymes | 16 | 2.436506e-02 | 1 |
| REAC | REAC:R-HSA-4839726 | Chromatin organization | Chromatin organization | 16 | 2.436506e-02 | 1 |
| REAC | REAC:R-HSA-8939211 | ESR-mediated signaling | ESR-mediated signaling | 14 | 2.531163e-02 | 1 |
| REAC | REAC:R-HSA-171319 | Telomere Extension By Telomerase | Telomere Extension By Telomerase | 5 | 2.677568e-02 | 1 |
| REAC | REAC:R-HSA-9031628 | NGF-stimulated transcription | NGF-stimulated transcription | 6 | 3.216876e-02 | 1 |
| REAC | REAC:R-HSA-3214847 | HATs acetylate histones | HATs acetylate histones | 11 | 3.250024e-02 | 1 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 8 | 3.326341e-02 | 1 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 9 | 3.361260e-02 | 1 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 10 | 3.475251e-02 | 1 |
| REAC | REAC:R-HSA-3270619 | IRF3-mediated induction of type I IFN | IRF3-mediated induction of type I IFN | 4 | 3.557477e-02 | 1 |
| REAC | REAC:R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 4 | 3.557477e-02 | 1 |
| REAC | REAC:R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 4 | 3.557477e-02 | 1 |
| REAC | REAC:R-HSA-8853884 | Transcriptional Regulation by VENTX | Transcriptional Regulation by VENTX | 6 | 3.742722e-02 | 1 |
| REAC | REAC:R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | APC/C:Cdc20 mediated degradation of mitotic proteins | 8 | 4.030024e-02 | 1 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 14 | 4.337366e-02 | 1 |
| REAC | REAC:R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | 8 | 4.425639e-02 | 1 |
| REAC | REAC:R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 8 | 4.425639e-02 | 1 |
| REAC | REAC:R-HSA-8941856 | RUNX3 regulates NOTCH signaling | RUNX3 regulates NOTCH signaling | 4 | 4.907307e-02 | 1 |
| REAC | REAC:R-HSA-3371568 | Attenuation phase | Attenuation phase | 4 | 4.907307e-02 | 1 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 47 | 4.952559e-02 | 1 |
| REAC | REAC:R-HSA-3899300 | SUMOylation of transcription cofactors | SUMOylation of transcription cofactors | 6 | 4.999142e-02 | 1 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 36 | 2.192569e-46 | 1 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 36 | 2.192569e-46 | 1 |
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 27 | 1.257236e-36 | 1 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 57 | 1.792435e-29 | 1 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 51 | 1.771000e-26 | 1 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 102 | 1.037431e-25 | 1 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 56 | 8.590625e-24 | 1 |
| GO:MF | GO:0019887 | protein kinase regulator activity | "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] | 34 | 4.234106e-23 | 1 |
| GO:MF | GO:0016772 | transferase activity, transferring phosphorus-containing groups | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] | 66 | 1.078515e-22 | 1 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 48 | 3.440954e-22 | 1 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 87 | 7.974128e-22 | 1 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 43 | 3.021490e-21 | 1 |
| GO:MF | GO:0019207 | kinase regulator activity | "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] | 34 | 5.885949e-21 | 1 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 56 | 9.467809e-21 | 1 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 249 | 6.623687e-20 | 1 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 57 | 1.868542e-19 | 1 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 98 | 2.607377e-19 | 1 |
| GO:MF | GO:0140097 | catalytic activity, acting on DNA | "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] | 31 | 1.308124e-18 | 1 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 49 | 9.922953e-18 | 1 |
| GO:MF | GO:0016740 | transferase activity | "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-] | 90 | 1.652541e-17 | 1 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 44 | 1.266949e-15 | 1 |
| GO:MF | GO:0003690 | double-stranded DNA binding | "Binding to double-stranded DNA." [GOC:elh, GOC:vw] | 61 | 5.970196e-12 | 1 |
| GO:MF | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity | "Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810] | 9 | 6.464402e-12 | 1 |
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 18 | 1.144296e-11 | 1 |
| GO:MF | GO:0003678 | DNA helicase activity | "Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl] | 13 | 1.812201e-10 | 1 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 58 | 3.705347e-10 | 1 |
| GO:MF | GO:0003712 | transcription coregulator activity | "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] | 30 | 5.302269e-10 | 1 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 141 | 8.737010e-10 | 1 |
| GO:MF | GO:0140640 | catalytic activity, acting on a nucleic acid | "Catalytic activity that acts to modify a nucleic acid." [GOC:pg] | 34 | 9.572789e-10 | 1 |
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 63 | 1.119735e-09 | 1 |
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 25 | 1.366829e-09 | 1 |
| GO:MF | GO:0043539 | protein serine/threonine kinase activator activity | "Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators] | 13 | 1.546389e-09 | 1 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 47 | 2.592318e-09 | 1 |
| GO:MF | GO:0030332 | cyclin binding | "Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] | 10 | 4.196696e-09 | 1 |
| GO:MF | GO:0030295 | protein kinase activator activity | "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] | 16 | 6.995655e-09 | 1 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 42 | 9.762709e-09 | 1 |
| GO:MF | GO:1990837 | sequence-specific double-stranded DNA binding | "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] | 53 | 1.016320e-08 | 1 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 23 | 1.344124e-08 | 1 |
| GO:MF | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr] | 7 | 1.684592e-08 | 1 |
| GO:MF | GO:0019209 | kinase activator activity | "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] | 16 | 1.707165e-08 | 1 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 22 | 2.883226e-08 | 1 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 116 | 8.294039e-08 | 1 |
| GO:MF | GO:0003684 | damaged DNA binding | "Binding to damaged DNA." [GOC:jl] | 12 | 9.383168e-08 | 1 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 53 | 1.114188e-07 | 1 |
| GO:MF | GO:0042393 | histone binding | "Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837] | 19 | 1.377459e-07 | 1 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 31 | 1.429374e-07 | 1 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 50 | 1.593540e-07 | 1 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 14 | 2.294768e-07 | 1 |
| GO:MF | GO:0120545 | nucleic acid conformation isomerase activity | "Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-] | 16 | 2.357495e-07 | 1 |
| GO:MF | GO:0030234 | enzyme regulator activity | "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 46 | 2.529669e-07 | 1 |
| GO:MF | GO:0003713 | transcription coactivator activity | "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 19 | 2.924431e-07 | 1 |
| GO:MF | GO:0001216 | DNA-binding transcription activator activity | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018] | 26 | 3.307386e-07 | 1 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 50 | 4.061792e-07 | 1 |
| GO:MF | GO:0098772 | molecular function regulator activity | "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt] | 62 | 4.193436e-07 | 1 |
| GO:MF | GO:0000976 | transcription cis-regulatory region binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] | 48 | 7.491241e-07 | 1 |
| GO:MF | GO:0001067 | transcription regulatory region nucleic acid binding | "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] | 48 | 7.657793e-07 | 1 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 256 | 8.410843e-07 | 1 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 29 | 9.094847e-07 | 1 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 23 | 1.426583e-06 | 1 |
| GO:MF | GO:0002039 | p53 binding | "Binding to one of the p53 family of proteins." [GOC:hjd] | 10 | 7.370283e-06 | 1 |
| GO:MF | GO:0004386 | helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] | 14 | 7.430408e-06 | 1 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 18 | 1.644267e-05 | 1 |
| GO:MF | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] | 23 | 2.456803e-05 | 1 |
| GO:MF | GO:0008353 | RNA polymerase II CTD heptapeptide repeat kinase activity | "Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II." [EC:2.7.11.23, GOC:mah, PMID:28248323] | 5 | 3.479325e-05 | 1 |
| GO:MF | GO:0042826 | histone deacetylase binding | "Binding to histone deacetylase." [GOC:jl] | 12 | 3.671054e-05 | 1 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 41 | 3.723217e-05 | 1 |
| GO:MF | GO:0043425 | bHLH transcription factor binding | "Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] | 7 | 5.763102e-05 | 1 |
| GO:MF | GO:1990841 | promoter-specific chromatin binding | "Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729] | 9 | 8.754531e-05 | 1 |
| GO:MF | GO:0106310 | protein serine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989] | 19 | 8.773092e-05 | 1 |
| GO:MF | GO:0003714 | transcription corepressor activity | "A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 14 | 1.315842e-04 | 1 |
| GO:MF | GO:0001221 | transcription coregulator binding | "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] | 11 | 1.476209e-04 | 1 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 59 | 1.886676e-04 | 1 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 59 | 2.423986e-04 | 1 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 61 | 2.955812e-04 | 1 |
| GO:MF | GO:0030291 | protein serine/threonine kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah] | 7 | 3.492091e-04 | 1 |
| GO:MF | GO:0010484 | histone H3 acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [PMID:19056256] | 5 | 3.935904e-04 | 1 |
| GO:MF | GO:0008047 | enzyme activator activity | "Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 24 | 4.745013e-04 | 1 |
| GO:MF | GO:0048156 | tau protein binding | "Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] | 7 | 4.898218e-04 | 1 |
| GO:MF | GO:0016853 | isomerase activity | "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] | 20 | 6.701487e-04 | 1 |
| GO:MF | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity | "Catalysis of the reaction: a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H+." [PMID:11251121, PMID:16120966, PMID:9614142, RHEA:76255] | 4 | 7.825513e-04 | 1 |
| GO:MF | GO:0001223 | transcription coactivator binding | "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] | 7 | 9.155201e-04 | 1 |
| GO:MF | GO:0043993 | histone H3K18 acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)." [PMID:18552846] | 3 | 9.274776e-04 | 1 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 34 | 1.128472e-03 | 1 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 54 | 1.139763e-03 | 1 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 51 | 1.557381e-03 | 1 |
| GO:MF | GO:1990757 | ubiquitin ligase activator activity | "Binds to and increases the activity of a ubiquitin ligase." [GOC:dph, PMID:25619242] | 4 | 2.301020e-03 | 1 |
| GO:MF | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] | 38 | 2.716310e-03 | 1 |
| GO:MF | GO:0140677 | molecular function activator activity | "A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators] | 34 | 2.937488e-03 | 1 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 51 | 3.475465e-03 | 1 |
| GO:MF | GO:0140993 | histone modifying activity | "A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression." [GOC:pg] | 12 | 3.754704e-03 | 1 |
| GO:MF | GO:0017116 | single-stranded DNA helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl] | 5 | 4.058404e-03 | 1 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 51 | 4.329143e-03 | 1 |
| GO:MF | GO:0016922 | nuclear receptor binding | "Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand." [PMID:7776974] | 10 | 4.982045e-03 | 1 |
| GO:MF | GO:0035035 | histone acetyltransferase binding | "Binding to an histone acetyltransferase." [GOC:bf] | 5 | 5.073471e-03 | 1 |
| GO:MF | GO:0004520 | DNA endonuclease activity | "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] | 6 | 5.608423e-03 | 1 |
| GO:MF | GO:0035173 | histone kinase activity | "Catalysis of the transfer of a phosphate group to a histone." [GOC:bf] | 5 | 6.276372e-03 | 1 |
| GO:MF | GO:0140994 | RNA polymerase II CTD heptapeptide repeat modifying activity | "A catalytic activity that acts on the RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS). Reversible modifications cof the RNA polymerase II CTD repeats contribute to regulation of RNA polymerase activity." [GOC:pg] | 5 | 6.276372e-03 | 1 |
| GO:MF | GO:0001046 | core promoter sequence-specific DNA binding | "Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH] | 6 | 6.474070e-03 | 1 |
| GO:MF | GO:0004536 | DNA nuclease activity | "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] | 7 | 9.235005e-03 | 1 |
| GO:MF | GO:0016746 | acyltransferase activity | "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [EC:2.3.-.-] | 25 | 9.643500e-03 | 1 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 50 | 1.146948e-02 | 1 |
| GO:MF | GO:0000987 | cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018] | 33 | 1.221813e-02 | 1 |
| GO:MF | GO:0097718 | disordered domain specific binding | "Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698] | 5 | 1.345882e-02 | 1 |
| GO:MF | GO:0097027 | ubiquitin-protein transferase activator activity | "Binds to and increases the activity of a ubiquitin-protein transferase." [GOC:rb, PMID:18321851] | 4 | 1.877898e-02 | 1 |
| GO:MF | GO:0004860 | protein kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a protein kinase." [GOC:ai] | 7 | 2.136213e-02 | 1 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 57 | 2.487450e-02 | 1 |
| GO:MF | GO:0140030 | modification-dependent protein binding | "Binding to a protein upon post-translation modification of the target protein." [PMID:26060076] | 10 | 3.000719e-02 | 1 |
| GO:MF | GO:0019210 | kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a kinase." [GOC:mah] | 7 | 3.239955e-02 | 1 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 54 | 3.802777e-02 | 1 |
| GO:MF | GO:0070182 | DNA polymerase binding | "Binding to a DNA polymerase." [GOC:BHF, GOC:mah] | 4 | 4.803175e-02 | 1 |
| GO:MF | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018] | 31 | 4.839512e-02 | 1 |
| GO:MF | GO:0048256 | flap endonuclease activity | "Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid] | 3 | 4.954323e-02 | 1 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0570781 | Testis; preleptotene spermatocytes[≥Low] | Testis; preleptotene spermatocytes[≥Low] | 81 | 5.056965e-12 | 1 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 113 | 6.805805e-12 | 1 |
| HPA | HPA:0570782 | Testis; preleptotene spermatocytes[≥Medium] | Testis; preleptotene spermatocytes[≥Medium] | 65 | 2.502433e-09 | 1 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 156 | 1.238410e-08 | 1 |
| HPA | HPA:0620000 | Vagina | Vagina | 156 | 1.238410e-08 | 1 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 46 | 1.367447e-08 | 1 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 139 | 2.455324e-08 | 1 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 121 | 2.784435e-08 | 1 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 162 | 1.012889e-07 | 1 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 162 | 1.012889e-07 | 1 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 122 | 1.816124e-07 | 1 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 157 | 2.964364e-07 | 1 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 157 | 2.964364e-07 | 1 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 46 | 3.711493e-07 | 1 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 59 | 6.267692e-07 | 1 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 153 | 6.342360e-07 | 1 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 163 | 6.356248e-07 | 1 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 163 | 6.356248e-07 | 1 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 40 | 1.708427e-06 | 1 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 44 | 1.966648e-06 | 1 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 48 | 2.324247e-06 | 1 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 150 | 3.088355e-06 | 1 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 38 | 4.121710e-06 | 1 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 94 | 4.603139e-06 | 1 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 120 | 4.882769e-06 | 1 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 41 | 7.764922e-06 | 1 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 35 | 9.131216e-06 | 1 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 157 | 1.711793e-05 | 1 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 44 | 2.099402e-05 | 1 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 150 | 2.128155e-05 | 1 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 35 | 2.659042e-05 | 1 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 40 | 2.805176e-05 | 1 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 168 | 5.265425e-05 | 1 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 168 | 5.265425e-05 | 1 |
| HPA | HPA:0060851 | Bronchus; ciliated cells (cell body)[≥Low] | Bronchus; ciliated cells (cell body)[≥Low] | 47 | 6.802417e-05 | 1 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 175 | 7.759842e-05 | 1 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 48 | 9.746068e-05 | 1 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 36 | 1.038048e-04 | 1 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 163 | 1.053493e-04 | 1 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 20 | 1.679159e-04 | 1 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 31 | 1.992769e-04 | 1 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 31 | 2.692456e-04 | 1 |
| HPA | HPA:0210851 | Fallopian tube; ciliated cells (cell body)[≥Low] | Fallopian tube; ciliated cells (cell body)[≥Low] | 40 | 2.866754e-04 | 1 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 34 | 3.116836e-04 | 1 |
| HPA | HPA:0570762 | Testis; pachytene spermatocytes[≥Medium] | Testis; pachytene spermatocytes[≥Medium] | 63 | 3.118905e-04 | 1 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 78 | 3.191377e-04 | 1 |
| HPA | HPA:0060843 | Bronchus; basal cells[High] | Bronchus; basal cells[High] | 14 | 3.817074e-04 | 1 |
| HPA | HPA:0380000 | Placenta | Placenta | 169 | 3.933807e-04 | 1 |
| HPA | HPA:0320851 | Nasopharynx; ciliated cells (cell body)[≥Low] | Nasopharynx; ciliated cells (cell body)[≥Low] | 44 | 4.010280e-04 | 1 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 29 | 4.033166e-04 | 1 |
| HPA | HPA:0570761 | Testis; pachytene spermatocytes[≥Low] | Testis; pachytene spermatocytes[≥Low] | 73 | 4.712332e-04 | 1 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 18 | 4.982824e-04 | 1 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 37 | 6.338261e-04 | 1 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 26 | 6.446900e-04 | 1 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 28 | 7.014585e-04 | 1 |
| HPA | HPA:0320852 | Nasopharynx; ciliated cells (cell body)[≥Medium] | Nasopharynx; ciliated cells (cell body)[≥Medium] | 37 | 8.040254e-04 | 1 |
| HPA | HPA:0060841 | Bronchus; basal cells[≥Low] | Bronchus; basal cells[≥Low] | 29 | 9.221851e-04 | 1 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 35 | 1.036206e-03 | 1 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 133 | 1.079705e-03 | 1 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 38 | 1.199376e-03 | 1 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 105 | 1.490217e-03 | 1 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 163 | 1.512136e-03 | 1 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 106 | 1.651132e-03 | 1 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 31 | 2.214742e-03 | 1 |
| HPA | HPA:0570783 | Testis; preleptotene spermatocytes[High] | Testis; preleptotene spermatocytes[High] | 32 | 2.218378e-03 | 1 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 44 | 2.271125e-03 | 1 |
| HPA | HPA:0630000 | Cervix | Cervix | 157 | 2.752372e-03 | 1 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 96 | 2.839858e-03 | 1 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 108 | 3.137616e-03 | 1 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 124 | 3.378132e-03 | 1 |
| HPA | HPA:0060852 | Bronchus; ciliated cells (cell body)[≥Medium] | Bronchus; ciliated cells (cell body)[≥Medium] | 35 | 3.472853e-03 | 1 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 152 | 3.667916e-03 | 1 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 21 | 3.763760e-03 | 1 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 35 | 3.924250e-03 | 1 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 19 | 4.180803e-03 | 1 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 21 | 4.552456e-03 | 1 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 43 | 4.919675e-03 | 1 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 21 | 6.127936e-03 | 1 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 30 | 6.614996e-03 | 1 |
| HPA | HPA:0570000 | Testis | Testis | 188 | 6.693307e-03 | 1 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 49 | 6.768256e-03 | 1 |
| HPA | HPA:0401331 | Rectum; mucosal lymphoid cells[≥Low] | Rectum; mucosal lymphoid cells[≥Low] | 25 | 7.042412e-03 | 1 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 30 | 7.348537e-03 | 1 |
| HPA | HPA:0211091 | Fallopian tube; non-ciliated cells[≥Low] | Fallopian tube; non-ciliated cells[≥Low] | 31 | 7.582714e-03 | 1 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 25 | 9.253888e-03 | 1 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 20 | 9.498513e-03 | 1 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 50 | 9.599926e-03 | 1 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 28 | 9.753857e-03 | 1 |
| HPA | HPA:0401293 | Rectum; endocrine cells[High] | Rectum; endocrine cells[High] | 16 | 1.096051e-02 | 1 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 30 | 1.288217e-02 | 1 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 129 | 1.295391e-02 | 1 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 129 | 1.295391e-02 | 1 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 163 | 1.428833e-02 | 1 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 22 | 1.498617e-02 | 1 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 42 | 1.811752e-02 | 1 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 25 | 1.853788e-02 | 1 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 31 | 1.869233e-02 | 1 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 40 | 1.880438e-02 | 1 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 119 | 1.966463e-02 | 1 |
| HPA | HPA:0131331 | Colon; mucosal lymphoid cells[≥Low] | Colon; mucosal lymphoid cells[≥Low] | 23 | 2.029720e-02 | 1 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 32 | 2.041048e-02 | 1 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 34 | 2.064374e-02 | 1 |
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 19 | 2.183877e-02 | 1 |
| HPA | HPA:0401301 | Rectum; enterocytes[≥Low] | Rectum; enterocytes[≥Low] | 23 | 2.218600e-02 | 1 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 28 | 2.535777e-02 | 1 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 91 | 2.601025e-02 | 1 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 17 | 2.697725e-02 | 1 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 158 | 3.038816e-02 | 1 |
| HPA | HPA:0320893 | Nasopharynx; goblet cells[High] | Nasopharynx; goblet cells[High] | 11 | 3.053885e-02 | 1 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 21 | 3.079471e-02 | 1 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 39 | 3.133251e-02 | 1 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 59 | 3.145305e-02 | 1 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 16 | 3.161242e-02 | 1 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 120 | 3.305429e-02 | 1 |
| HPA | HPA:0130000 | Colon | Colon | 176 | 3.431705e-02 | 1 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 125 | 4.103998e-02 | 1 |
| HPA | HPA:0481301 | Small intestine; enterocytes[≥Low] | Small intestine; enterocytes[≥Low] | 24 | 4.177274e-02 | 1 |
| HPA | HPA:0380523 | Placenta; trophoblastic cells[High] | Placenta; trophoblastic cells[High] | 57 | 4.199633e-02 | 1 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 14 | 4.305030e-02 | 1 |
| HPA | HPA:0210852 | Fallopian tube; ciliated cells (cell body)[≥Medium] | Fallopian tube; ciliated cells (cell body)[≥Medium] | 26 | 4.608810e-02 | 1 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 14 | 4.696100e-02 | 1 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 43 | 1.384637e-10 | 1 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 49 | 6.794280e-07 | 1 |
| MIRNA | MIRNA:hsa-mir-34a-5p | hsa-mir-34a-5p | hsa-mir-34a-5p | 28 | 1.579155e-05 | 1 |
| MIRNA | MIRNA:hsa-let-7b-5p | hsa-let-7b-5p | hsa-let-7b-5p | 41 | 1.049567e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-24-3p | hsa-mir-24-3p | hsa-mir-24-3p | 32 | 1.535427e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-221-3p | hsa-mir-221-3p | hsa-mir-221-3p | 20 | 4.385680e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-192-5p | hsa-mir-192-5p | hsa-mir-192-5p | 34 | 8.009418e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-26a-5p | hsa-mir-26a-5p | hsa-mir-26a-5p | 21 | 1.561493e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-29a-3p | hsa-mir-29a-3p | hsa-mir-29a-3p | 15 | 1.679004e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-215-5p | hsa-mir-215-5p | hsa-mir-215-5p | 28 | 2.140667e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-429 | hsa-mir-429 | hsa-mir-429 | 44 | 2.635502e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-145-3p | hsa-mir-145-3p | hsa-mir-145-3p | 8 | 3.025050e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-200c | hsa-mir-200c | hsa-mir-200c | 43 | 3.164102e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-200b | hsa-mir-200b | hsa-mir-200b | 43 | 3.164102e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-222-3p | hsa-mir-222-3p | hsa-mir-222-3p | 19 | 3.218493e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-138-5p | hsa-mir-138-5p | hsa-mir-138-5p | 10 | 3.810280e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-30c-5p | hsa-mir-30c-5p | hsa-mir-30c-5p | 22 | 4.155532e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-223-3p | hsa-mir-223-3p | hsa-mir-223-3p | 10 | 5.778523e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-4268 | hsa-mir-4268 | hsa-mir-4268 | 31 | 5.788366e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-205-5p | hsa-mir-205-5p | hsa-mir-205-5p | 12 | 1.167519e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-125b-5p | hsa-mir-125b-5p | hsa-mir-125b-5p | 19 | 1.324757e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-675-5p | hsa-mir-675-5p | hsa-mir-675-5p | 7 | 1.371565e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-503-5p | hsa-mir-503-5p | hsa-mir-503-5p | 14 | 1.475318e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-20a-5p | hsa-mir-20a-5p | hsa-mir-20a-5p | 33 | 1.731421e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-18a-5p | hsa-mir-18a-5p | hsa-mir-18a-5p | 14 | 2.221587e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-449b-5p | hsa-mir-449b-5p | hsa-mir-449b-5p | 9 | 2.346703e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-6871-5p | hsa-mir-6871-5p | hsa-mir-6871-5p | 8 | 3.060174e-02 | 1 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002894 | Neoplasm of the pancreas | A tumor (abnormal growth of tissue) of the pancreas. | 17 | 4.395691e-10 | 1 |
| HP | HP:0010785 | Gonadal neoplasm | A tumor (abnormal growth of tissue) of a gonad. | 17 | 8.006989e-09 | 1 |
| HP | HP:0010460 | Abnormality of the female genitalia | Abnormality of the female genital system. | 36 | 2.409946e-08 | 1 |
| HP | HP:0010787 | Genital neoplasm | A tumor (abnormal growth of tissue) of the genital system. | 19 | 7.092603e-08 | 1 |
| HP | HP:0000812 | Abnormal internal genitalia | An anomaly of the adnexa, uterus, and vagina (in female) or seminal tract and prostate (in male). | 34 | 2.287464e-07 | 1 |
| HP | HP:0007378 | Neoplasm of the gastrointestinal tract | A tumor (abnormal growth of tissue) of the gastrointestinal tract. | 25 | 2.422960e-07 | 1 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 22 | 3.675784e-07 | 1 |
| HP | HP:0011792 | Neoplasm by histology | Neoplasm categorized according to type of histological abnormality. | 27 | 3.794144e-07 | 1 |
| HP | HP:0000008 | Abnormal morphology of female internal genitalia | An abnormality of the female internal genitalia. | 31 | 4.947772e-07 | 1 |
| HP | HP:0000130 | Abnormality of the uterus | An abnormality of the uterus. | 22 | 2.481426e-06 | 1 |
| HP | HP:0034930 | Digestive system neoplasm | A tumor (abnormal growth of tissue) of the digestive system. | 26 | 2.625993e-06 | 1 |
| HP | HP:0030406 | Primary peritoneal carcinoma | A type of cancer that originates in the peritoneum. It is to be distinguished from metastatic cancer of the peritoneum. Peritoneal cancer can occur anywhere in the abdominal space, and affects the surface of organs contained inside the peritoneum. | 7 | 4.241888e-06 | 1 |
| HP | HP:0000769 | Abnormality of the breast | An abnormality of the breast. | 28 | 1.809354e-05 | 1 |
| HP | HP:0100013 | Neoplasm of the breast | A tumor (abnormal growth of tissue) of the breast. | 13 | 4.029963e-05 | 1 |
| HP | HP:0011024 | Abnormality of the gastrointestinal tract | An abnormality of the gastrointestinal tract. | 60 | 7.246502e-05 | 1 |
| HP | HP:0006753 | Neoplasm of the stomach | A tumor (abnormal growth of tissue) of the stomach. | 12 | 7.941836e-05 | 1 |
| HP | HP:0100615 | Ovarian neoplasm | A tumor (abnormal growth of tissue) of the ovary. | 11 | 1.986441e-04 | 1 |
| HP | HP:0031105 | Abnormal uterus morphology | Any anomaly of the structure of the uterus | 15 | 3.102195e-04 | 1 |
| HP | HP:0002861 | Melanoma | The presence of a melanoma, a malignant cancer originating from pigment producing melanocytes. Melanoma can originate from the skin or the pigmented layers of the eye (the uvea). | 11 | 4.530777e-04 | 1 |
| HP | HP:0010786 | Urinary tract neoplasm | The presence of a neoplasm of the urinary system. | 14 | 6.633760e-04 | 1 |
| HP | HP:0000059 | Hypoplastic labia majora | Undergrowth of the outer labia. | 8 | 7.466908e-04 | 1 |
| HP | HP:0100783 | Breast aplasia | Failure to develop and congenital absence of the breast. | 6 | 8.026060e-04 | 1 |
| HP | HP:0011027 | Abnormal fallopian tube morphology | An abnormality of the fallopian tube. | 7 | 8.957850e-04 | 1 |
| HP | HP:0031093 | Abnormal breast morphology | Any anomaly of the structure of the breast. | 25 | 9.837493e-04 | 1 |
| HP | HP:0012334 | Extrahepatic cholestasis | Impairment of bile flow due to obstruction in large bile ducts outside the liver. | 5 | 9.905689e-04 | 1 |
| HP | HP:0002246 | Abnormal duodenum morphology | An abnormality of the duodenum, i.e., the first section of the small intestine. | 11 | 1.220225e-03 | 1 |
| HP | HP:0003002 | Breast carcinoma | The presence of a carcinoma of the breast. | 10 | 1.316718e-03 | 1 |
| HP | HP:0030310 | Upper extremity joint dislocation | Displacement or malalignment of one or more joints in the upper extremity (arm). | 11 | 1.536995e-03 | 1 |
| HP | HP:0000172 | Abnormal uvula morphology | Abnormality of the uvula, the conic projection from the posterior edge of the middle of the soft palate. | 16 | 1.718233e-03 | 1 |
| HP | HP:0011267 | Microtia, third degree | Presence of some auricular structures, but none of these structures conform to recognized ear components. | 5 | 1.788646e-03 | 1 |
| HP | HP:0100006 | Neoplasm of the central nervous system | A neoplasm of the central nervous system. | 15 | 1.896290e-03 | 1 |
| HP | HP:0030063 | Neuroepithelial neoplasm | A neoplasm composed of neural epithelium, not necessarily a neoplasm located in the neural epithelium or neuroepithelium. | 11 | 1.924187e-03 | 1 |
| HP | HP:0030060 | Nervous tissue neoplasm | A neoplasm derived from nervous tissue (not necessarily a neoplasm located in the nervous system). | 11 | 2.148208e-03 | 1 |
| HP | HP:0030061 | Neuroectodermal neoplasm | A neoplasm arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells. | 11 | 2.148208e-03 | 1 |
| HP | HP:0006740 | Transitional cell carcinoma of the bladder | The presence of a carcinoma of the urinary bladder with origin in a transitional epithelial cell. | 7 | 2.491914e-03 | 1 |
| HP | HP:0009726 | Renal neoplasm | The presence of a neoplasm of the kidney. | 13 | 2.807511e-03 | 1 |
| HP | HP:0002588 | Duodenal ulcer | An erosion of the mucous membrane in a portion of the duodenum. | 5 | 3.020005e-03 | 1 |
| HP | HP:0006716 | Hereditary nonpolyposis colorectal carcinoma | Hereditary nonpolyposis colorectal carcinoma | 7 | 3.140238e-03 | 1 |
| HP | HP:0007400 | Irregular hyperpigmentation | Irregular hyperpigmentation | 17 | 3.466238e-03 | 1 |
| HP | HP:0012881 | Abnormal labia majora morphology | An anomaly of the outer labia. | 8 | 3.513737e-03 | 1 |
| HP | HP:0002862 | Bladder carcinoma | The presence of a carcinoma of the urinary bladder. | 7 | 3.923948e-03 | 1 |
| HP | HP:0100787 | Prostate neoplasm | Prostate neoplasm | 7 | 3.923948e-03 | 1 |
| HP | HP:0012125 | Prostate cancer | A cancer of the prostate. | 7 | 3.923948e-03 | 1 |
| HP | HP:0003042 | Elbow dislocation | Dislocation of the distal humerus out of the elbow joint, where the radius, ulna, and humerus meet. | 10 | 4.074337e-03 | 1 |
| HP | HP:0012718 | Abnormal gastrointestinal tract morphology | Abnormal structure of the gastrointestinal tract. | 38 | 4.215841e-03 | 1 |
| HP | HP:0004209 | Clinodactyly of the 5th finger | Clinodactyly refers to a bending or curvature of the fifth finger in the radial direction (i.e., towards the 4th finger). | 23 | 4.742978e-03 | 1 |
| HP | HP:0009939 | Mandibular aplasia | Absence of the mandible. | 5 | 4.833515e-03 | 1 |
| HP | HP:0009725 | Bladder neoplasm | The presence of a neoplasm of the urinary bladder. | 7 | 4.864735e-03 | 1 |
| HP | HP:0040019 | Finger clinodactyly | Finger clinodactyly | 24 | 4.887852e-03 | 1 |
| HP | HP:0009733 | Glioma | The presence of a glioma, which is a neoplasm of the central nervous system originating from a glial cell (astrocytes or oligodendrocytes). | 8 | 4.924325e-03 | 1 |
| HP | HP:0009179 | Deviation of the 5th finger | Displacement of the 5th finger from its normal position. | 23 | 4.941399e-03 | 1 |
| HP | HP:0100242 | Sarcoma | A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant. | 14 | 5.166944e-03 | 1 |
| HP | HP:0001824 | Weight loss | Reduction of total body weight. | 22 | 5.515268e-03 | 1 |
| HP | HP:0002577 | Abnormal stomach morphology | An abnormality of the stomach. | 18 | 5.867402e-03 | 1 |
| HP | HP:0004375 | Neoplasm of the nervous system | A tumor (abnormal growth of tissue) of the nervous system. | 15 | 6.033025e-03 | 1 |
| HP | HP:0100835 | Benign neoplasm of the central nervous system | Benign neoplasm of the central nervous system | 11 | 6.609077e-03 | 1 |
| HP | HP:0001442 | Typified by somatic mosaicism | Description of conditions in which affected individuals typically display somatic mosaicism, i.e., genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations. In many conditions typified by somatic mosaicism, constitutive mutation is lethal and cases are exclusively or predominantly mosaic. | 14 | 7.323571e-03 | 1 |
| HP | HP:0009892 | Anotia | Complete absence of any auricular structures. | 5 | 7.405467e-03 | 1 |
| HP | HP:0001034 | Hypermelanotic macule | A hyperpigmented circumscribed area of change in normal skin color without elevation or depression of any size. | 15 | 8.273869e-03 | 1 |
| HP | HP:0010784 | Uterine neoplasm | A tumor (abnormal growth of tissue) of the uterus. | 9 | 8.355332e-03 | 1 |
| HP | HP:0004097 | Deviation of finger | Deviated fingers is a term that should be used if one or more fingers of the hand are deviated from their normal position, either to the radial or ulnar side. A deviation of a finger can be caused by an abnormal form of one or more of the phalanges of the affected finger, or by a deviation or displacement of one or more phalanges. | 26 | 8.778657e-03 | 1 |
| HP | HP:0002242 | Abnormal intestine morphology | An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine. | 32 | 8.959163e-03 | 1 |
| HP | HP:0012432 | Chronic fatigue | Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer. | 6 | 1.014947e-02 | 1 |
| HP | HP:0000415 | Abnormal choanae morphology | Abnormality of the choanae (the posterior nasal apertures). | 12 | 1.349324e-02 | 1 |
| HP | HP:0033020 | Female reproductive system neoplasm | A neoplasm that affects the female reproductive system. | 9 | 1.354992e-02 | 1 |
| HP | HP:0000022 | Abnormal male internal genitalia morphology | An abnormality of the male internal genitalia. | 10 | 1.476802e-02 | 1 |
| HP | HP:0001732 | Abnormality of the pancreas | An abnormality of the pancreas. | 19 | 1.526530e-02 | 1 |
| HP | HP:0030445 | Pulmonary carcinoid tumor | A malignant neuroendocrine tumor of the lung. According to histopathologic criteria (WHO 2004), carcinoids are divided into four groups i.e. typical and atypical carcinoids, large cell neuroendocrine carcinoma and small cell lung carcinoma. | 4 | 1.527651e-02 | 1 |
| HP | HP:0000240 | Abnormality of skull size | Any abnormality of the size of the skull. | 52 | 1.570932e-02 | 1 |
| HP | HP:0000160 | Narrow mouth | Distance between the commissures of the mouth more than 2 SD below the mean. Alternatively, an apparently decreased width of the oral aperture (subjective). | 16 | 1.590707e-02 | 1 |
| HP | HP:0001511 | Intrauterine growth retardation | An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age. | 28 | 1.749386e-02 | 1 |
| HP | HP:0100834 | Neoplasm of the large intestine | The presence of a neoplasm of the large intestine. | 11 | 1.772723e-02 | 1 |
| HP | HP:0008775 | Abnormal prostate morphology | An abnormality of the prostate. | 7 | 1.822664e-02 | 1 |
| HP | HP:0000953 | Hyperpigmentation of the skin | A darkening of the skin related to an increase in melanin production and deposition. | 19 | 1.824288e-02 | 1 |
| HP | HP:0006749 | Malignant gastrointestinal tract tumors | Malignant gastrointestinal tract tumors | 9 | 1.907227e-02 | 1 |
| HP | HP:0002672 | Gastrointestinal carcinoma | Gastrointestinal carcinoma | 9 | 1.907227e-02 | 1 |
| HP | HP:0100243 | Leiomyosarcoma | A smooth muscle connective tissue tumor, which is rare type of cancer that is a malignant neoplasm of smooth muscle. When such a neoplasm is benign, it is called a leiomyoma. | 6 | 2.061339e-02 | 1 |
| HP | HP:0002891 | Uterine leiomyosarcoma | The presence of a leiomyosarcoma of the uterus. | 6 | 2.061339e-02 | 1 |
| HP | HP:0002896 | Neoplasm of the liver | A tumor (abnormal growth of tissue) of the liver. | 12 | 2.123611e-02 | 1 |
| HP | HP:0100736 | Abnormal soft palate morphology | An abnormality of the soft palate. | 17 | 2.133856e-02 | 1 |
| HP | HP:0000413 | Atresia of the external auditory canal | Absence or failure to form of the external auditory canal. | 8 | 2.138035e-02 | 1 |
| HP | HP:0009484 | Deviation of the hand or of fingers of the hand | Displacement of the hand or of fingers of the hand from their normal position. | 26 | 2.165952e-02 | 1 |
| HP | HP:0000039 | Epispadias | Epispadias is a urogenital malformation characterized by the failure of the urethral tube to tubularize on the dorsal aspect. Unlike in hypospadias, where the meatus is on the ventral aspect, children with epispadias have a wide-open urethral plate on the dorsum. It is commonly seen as a component in the spectrum of bladder exstrophy-epispadias-complex. Isolated epispadias constitutes less than 10 percent of the total cases of epispadias. | 6 | 2.559272e-02 | 1 |
| HP | HP:0100836 | Malignant neoplasm of the central nervous system | A tumor that originates in the pineal gland, has moderate cellularity and tends to form rosette patterns. | 10 | 2.609566e-02 | 1 |
| HP | HP:0030448 | Soft tissue sarcoma | A type of sarcoma (A connective tissue neoplasm formed by proliferation of mesodermal cells) that develops from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues. | 11 | 2.672575e-02 | 1 |
| HP | HP:0008261 | Pancreatic islet cell adenoma | The presence of an adenoma of the pancreas with origin in a pancreatic B cell. | 4 | 2.709541e-02 | 1 |
| HP | HP:0012719 | Functional abnormality of the gastrointestinal tract | Abnormal functionality of the gastrointestinal tract. | 43 | 2.790633e-02 | 1 |
| HP | HP:0000193 | Bifid uvula | Uvula separated into two parts most easily seen at the tip. | 13 | 2.915528e-02 | 1 |
| HP | HP:0030084 | Clinodactyly | An angulation of a digit at an interphalangeal joint in the plane of the palm (finger) or sole (toe). | 26 | 2.976459e-02 | 1 |
| HP | HP:0006744 | Adrenocortical carcinoma | A malignant neoplasm of the adrenal cortex that may produce hormones such as cortisol, aldosterone, estrogen, or testosterone. | 5 | 2.982650e-02 | 1 |
| HP | HP:0025033 | Abnormal digestive system morphology | A structural anomaly of the digestive system. | 38 | 3.204492e-02 | 1 |
| HP | HP:0012745 | Short palpebral fissure | Distance between the medial and lateral canthi is more than 2 SD below the mean for age (objective); or, apparently reduced length of the palpebral fissures. | 11 | 3.384559e-02 | 1 |
| HP | HP:0000453 | Choanal atresia | Absence or abnormal closure of the choana (the posterior nasal aperture). Most embryologists believe that posterior choanal atresia results from a failure of rupture between the 35th and 38th day of fetal life of the partition which separates the bucconasal or buccopharyngeal membranes. The resultant choanal atresia may be unilateral or bilateral, bony or membranous, complete or incomplete. In over 90 per cent of cases the obstruction is bony, while in the remainder it is membranous. The bony type of atresia is commonly located 1-2 mm. anterior to the posterior edge of the hard palate, and the osseous septum varies in thickness from 1 to 10 mm. In the membranous form of choanal atresia the obstruction usually occurs further posteriorly. In approximately one third of cases the atresia is bilateral. | 11 | 3.384559e-02 | 1 |
| HP | HP:0002664 | Neoplasm | An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor). | 36 | 3.422143e-02 | 1 |
| HP | HP:0000066 | Labial hypoplasia | Labial hypoplasia | 8 | 3.541936e-02 | 1 |
| HP | HP:0033019 | Male reproductive system neoplasm | A neoplasm that affects the male reproductive system. | 8 | 3.541936e-02 | 1 |
| HP | HP:0003072 | Hypercalcemia | An abnormally increased calcium concentration in the blood. | 9 | 3.604618e-02 | 1 |
| HP | HP:0004207 | Abnormal 5th finger morphology | An abnormality affecting one or both 5th fingers. | 24 | 3.676452e-02 | 1 |
| HP | HP:0006660 | Aplastic clavicle | Absence of the clavicles as a developmental defect. | 5 | 3.986954e-02 | 1 |
| HP | HP:0005249 | Functional intestinal obstruction | Functional intestinal obstruction | 4 | 4.449864e-02 | 1 |
| HP | HP:0031207 | Hepatic hemangioma | A congenital vascular malformation in the liver composed of masses of blood vessels that are atypical or irregular in arrangement and size. | 3 | 4.932025e-02 | 1 |
| HP | HP:0410266 | Visceral hemangioma | A hemangioma arising from within visceral structures, the internal organs of the body. | 3 | 4.932025e-02 | 1 |
| HP | HP:0011793 | Neoplasm by anatomical site | Neoplasm categorized according to the anatomical site of origin of the neoplasm. | 35 | 4.994877e-02 | 1 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11531_1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | 216 | 9.263133e-10 | 1 |
| TF | TF:M07250_1 | Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 | Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 | 127 | 2.468640e-09 | 1 |
| TF | TF:M00431_1 | Factor: E2F-1; motif: TTTSGCGS; match class: 1 | Factor: E2F-1; motif: TTTSGCGS; match class: 1 | 71 | 4.640011e-09 | 1 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 111 | 2.129205e-08 | 1 |
| TF | TF:M00939_1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | 58 | 2.292320e-08 | 1 |
| TF | TF:M00918 | Factor: E2F; motif: TTTSGCGSG | Factor: E2F; motif: TTTSGCGSG | 125 | 3.732880e-08 | 1 |
| TF | TF:M04869 | Factor: Egr-1; motif: GCGCATGCG | Factor: Egr-1; motif: GCGCATGCG | 200 | 3.758247e-08 | 1 |
| TF | TF:M00920 | Factor: E2F; motif: NKCGCGCSAAAN | Factor: E2F; motif: NKCGCGCSAAAN | 126 | 5.096748e-08 | 1 |
| TF | TF:M11531 | Factor: E2F-2; motif: GCGCGCGCGYW | Factor: E2F-2; motif: GCGCGCGCGYW | 222 | 5.823665e-08 | 1 |
| TF | TF:M00919_1 | Factor: E2F; motif: NCSCGCSAAAN; match class: 1 | Factor: E2F; motif: NCSCGCSAAAN; match class: 1 | 54 | 6.495811e-08 | 1 |
| TF | TF:M00516 | Factor: E2F-1; motif: TTTSGCGCGMNR | Factor: E2F-1; motif: TTTSGCGCGMNR | 143 | 1.089354e-07 | 1 |
| TF | TF:M00940 | Factor: E2F-1; motif: NTTTCGCGCS | Factor: E2F-1; motif: NTTTCGCGCS | 155 | 1.558293e-07 | 1 |
| TF | TF:M04869_1 | Factor: Egr-1; motif: GCGCATGCG; match class: 1 | Factor: Egr-1; motif: GCGCATGCG; match class: 1 | 186 | 2.896706e-07 | 1 |
| TF | TF:M00426_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 126 | 3.069234e-07 | 1 |
| TF | TF:M00427_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 94 | 5.887530e-07 | 1 |
| TF | TF:M00940_1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | 73 | 8.299872e-07 | 1 |
| TF | TF:M07039_1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | 223 | 8.320658e-07 | 1 |
| TF | TF:M00333_1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | 210 | 1.040498e-06 | 1 |
| TF | TF:M00431 | Factor: E2F-1; motif: TTTSGCGS | Factor: E2F-1; motif: TTTSGCGS | 145 | 1.334528e-06 | 1 |
| TF | TF:M00427 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 175 | 1.346706e-06 | 1 |
| TF | TF:M00918_1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | 45 | 2.272416e-06 | 1 |
| TF | TF:M08875_1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | 55 | 2.301235e-06 | 1 |
| TF | TF:M00919 | Factor: E2F; motif: NCSCGCSAAAN | Factor: E2F; motif: NCSCGCSAAAN | 128 | 3.405413e-06 | 1 |
| TF | TF:M08205_1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | 185 | 4.409868e-06 | 1 |
| TF | TF:M00738 | Factor: E2F-4:DP-1; motif: TTTSGCGC | Factor: E2F-4:DP-1; motif: TTTSGCGC | 177 | 5.215385e-06 | 1 |
| TF | TF:M00050_1 | Factor: E2F; motif: TTTSGCGC; match class: 1 | Factor: E2F; motif: TTTSGCGC; match class: 1 | 57 | 5.272110e-06 | 1 |
| TF | TF:M00426 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 202 | 5.581984e-06 | 1 |
| TF | TF:M00739_1 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 | 43 | 5.957380e-06 | 1 |
| TF | TF:M08875 | Factor: E2F; motif: NNTTTCGCGCN | Factor: E2F; motif: NNTTTCGCGCN | 128 | 6.562160e-06 | 1 |
| TF | TF:M00716_1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | 226 | 6.802712e-06 | 1 |
| TF | TF:M07250 | Factor: E2F-1; motif: NNNSSCGCSAANN | Factor: E2F-1; motif: NNNSSCGCSAANN | 188 | 6.819083e-06 | 1 |
| TF | TF:M00333 | Factor: ZF5; motif: NRNGNGCGCGCWN | Factor: ZF5; motif: NRNGNGCGCGCWN | 235 | 9.392133e-06 | 1 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 233 | 1.093916e-05 | 1 |
| TF | TF:M08874 | Factor: E2F1; motif: NNNNNGCGSSAAAN | Factor: E2F1; motif: NNNNNGCGSSAAAN | 141 | 1.376196e-05 | 1 |
| TF | TF:M00738_1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | 93 | 1.430746e-05 | 1 |
| TF | TF:M00986_1 | Factor: Churchill; motif: CGGGNN; match class: 1 | Factor: Churchill; motif: CGGGNN; match class: 1 | 183 | 1.530840e-05 | 1 |
| TF | TF:M00740_1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | 102 | 2.014840e-05 | 1 |
| TF | TF:M02089 | Factor: E2F-3; motif: GGCGGGN | Factor: E2F-3; motif: GGCGGGN | 215 | 2.156711e-05 | 1 |
| TF | TF:M02090 | Factor: E2F-4; motif: GCGGGAAANA | Factor: E2F-4; motif: GCGGGAAANA | 201 | 2.406623e-05 | 1 |
| TF | TF:M09896 | Factor: E2F-7; motif: GRGGCGGGAANNN | Factor: E2F-7; motif: GRGGCGGGAANNN | 177 | 2.507330e-05 | 1 |
| TF | TF:M10072 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | 184 | 2.516797e-05 | 1 |
| TF | TF:M00425_1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | 113 | 3.230028e-05 | 1 |
| TF | TF:M10438 | Factor: ZF5; motif: GGSGCGCGS | Factor: ZF5; motif: GGSGCGCGS | 244 | 3.907220e-05 | 1 |
| TF | TF:M02089_1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | 169 | 4.269125e-05 | 1 |
| TF | TF:M07206_1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | 187 | 5.976135e-05 | 1 |
| TF | TF:M00516_1 | Factor: E2F-1; motif: TTTSGCGCGMNR; match class: 1 | Factor: E2F-1; motif: TTTSGCGCGMNR; match class: 1 | 58 | 6.011933e-05 | 1 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 222 | 6.680395e-05 | 1 |
| TF | TF:M00939 | Factor: E2F; motif: TTTSGCGSG | Factor: E2F; motif: TTTSGCGSG | 128 | 6.943138e-05 | 1 |
| TF | TF:M00736 | Factor: E2F-1:DP-1; motif: TTTCSCGC | Factor: E2F-1:DP-1; motif: TTTCSCGC | 180 | 9.038864e-05 | 1 |
| TF | TF:M07084_1 | Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 | Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 | 113 | 9.838768e-05 | 1 |
| TF | TF:M01593 | Factor: Zfx; motif: SNSCAGGCCKCGSCSS | Factor: Zfx; motif: SNSCAGGCCKCGSCSS | 93 | 1.108206e-04 | 1 |
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 213 | 1.230198e-04 | 1 |
| TF | TF:M09896_1 | Factor: E2F-7; motif: GRGGCGGGAANNN; match class: 1 | Factor: E2F-7; motif: GRGGCGGGAANNN; match class: 1 | 99 | 1.332668e-04 | 1 |
| TF | TF:M12227 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN | Factor: ZIC4; motif: NNCCNCCCRYNGYGN | 188 | 1.547830e-04 | 1 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 238 | 1.632959e-04 | 1 |
| TF | TF:M03924 | Factor: YY1; motif: NNCGCCATTNN | Factor: YY1; motif: NNCGCCATTNN | 175 | 1.813678e-04 | 1 |
| TF | TF:M12598_1 | Factor: E2F3; motif: NNRGMKGGAR; match class: 1 | Factor: E2F3; motif: NNRGMKGGAR; match class: 1 | 134 | 1.851297e-04 | 1 |
| TF | TF:M08266_1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | 161 | 1.879178e-04 | 1 |
| TF | TF:M00920_1 | Factor: E2F; motif: NKCGCGCSAAAN; match class: 1 | Factor: E2F; motif: NKCGCGCSAAAN; match class: 1 | 42 | 1.966629e-04 | 1 |
| TF | TF:M00050 | Factor: E2F; motif: TTTSGCGC | Factor: E2F; motif: TTTSGCGC | 135 | 1.971400e-04 | 1 |
| TF | TF:M08525_1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | 234 | 1.981089e-04 | 1 |
| TF | TF:M04823_1 | Factor: E2F-4; motif: NNTTCCCGCCNN; match class: 1 | Factor: E2F-4; motif: NNTTCCCGCCNN; match class: 1 | 146 | 2.610031e-04 | 1 |
| TF | TF:M00938 | Factor: E2F-1; motif: TTGGCGCGRAANNGNM | Factor: E2F-1; motif: TTGGCGCGRAANNGNM | 138 | 2.928149e-04 | 1 |
| TF | TF:M12351_1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | 149 | 3.331649e-04 | 1 |
| TF | TF:M00740 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | 179 | 3.556802e-04 | 1 |
| TF | TF:M09723 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS | 174 | 3.689105e-04 | 1 |
| TF | TF:M00196 | Factor: Sp1; motif: NGGGGGCGGGGYN | Factor: Sp1; motif: NGGGGGCGGGGYN | 177 | 3.723864e-04 | 1 |
| TF | TF:M13366 | Factor: ZBED4; motif: CCCGCYCCGC | Factor: ZBED4; motif: CCCGCYCCGC | 143 | 3.839233e-04 | 1 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 179 | 3.839483e-04 | 1 |
| TF | TF:M08205 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | 225 | 4.072913e-04 | 1 |
| TF | TF:M08207_1 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 | 235 | 4.310582e-04 | 1 |
| TF | TF:M07380_1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | 147 | 4.830443e-04 | 1 |
| TF | TF:M01783 | Factor: SP2; motif: GGGCGGGAC | Factor: SP2; motif: GGGCGGGAC | 162 | 5.031069e-04 | 1 |
| TF | TF:M07380 | Factor: E2F-4; motif: NTTTCSCGCC | Factor: E2F-4; motif: NTTTCSCGCC | 209 | 5.526725e-04 | 1 |
| TF | TF:M07206 | Factor: E2F-1; motif: NGGGCGGGARV | Factor: E2F-1; motif: NGGGCGGGARV | 226 | 5.721274e-04 | 1 |
| TF | TF:M03862_1 | Factor: YB-1; motif: NNNNCCAATNN; match class: 1 | Factor: YB-1; motif: NNNNCCAATNN; match class: 1 | 73 | 6.078487e-04 | 1 |
| TF | TF:M08525 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM | 249 | 6.677735e-04 | 1 |
| TF | TF:M01857 | Factor: AP-2alpha; motif: NGCCYSNNGSN | Factor: AP-2alpha; motif: NGCCYSNNGSN | 162 | 7.002920e-04 | 1 |
| TF | TF:M02106 | Factor: NF-YA; motif: CRGCCAATCAGNRN | Factor: NF-YA; motif: CRGCCAATCAGNRN | 49 | 7.104904e-04 | 1 |
| TF | TF:M00428 | Factor: E2F-1; motif: NKTSSCGC | Factor: E2F-1; motif: NKTSSCGC | 159 | 7.732026e-04 | 1 |
| TF | TF:M09893_1 | Factor: E2F-3; motif: NNGGCGGGAAA; match class: 1 | Factor: E2F-3; motif: NNGGCGGGAAA; match class: 1 | 41 | 1.251196e-03 | 1 |
| TF | TF:M08266 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG | 222 | 1.338402e-03 | 1 |
| TF | TF:M02090_1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | 123 | 1.384769e-03 | 1 |
| TF | TF:M11530 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | 225 | 1.425213e-03 | 1 |
| TF | TF:M09892_1 | Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 | Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 | 161 | 1.630690e-03 | 1 |
| TF | TF:M11018_1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | 238 | 1.726663e-03 | 1 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 229 | 1.787912e-03 | 1 |
| TF | TF:M08874_1 | Factor: E2F1; motif: NNNNNGCGSSAAAN; match class: 1 | Factor: E2F1; motif: NNNNNGCGSSAAAN; match class: 1 | 56 | 1.873958e-03 | 1 |
| TF | TF:M00008 | Factor: Sp1; motif: GGGGCGGGGT | Factor: Sp1; motif: GGGGCGGGGT | 172 | 1.936287e-03 | 1 |
| TF | TF:M00931 | Factor: Sp1; motif: GGGGCGGGGC | Factor: Sp1; motif: GGGGCGGGGC | 175 | 2.000644e-03 | 1 |
| TF | TF:M04515 | Factor: E2F-1; motif: WWTGGCGCCAAA | Factor: E2F-1; motif: WWTGGCGCCAAA | 211 | 2.160062e-03 | 1 |
| TF | TF:M12642 | Factor: NFYA; motif: NNRGCCAATSRGMRSSNNSN | Factor: NFYA; motif: NNRGCCAATSRGMRSSNNSN | 66 | 2.647380e-03 | 1 |
| TF | TF:M00008_1 | Factor: Sp1; motif: GGGGCGGGGT; match class: 1 | Factor: Sp1; motif: GGGGCGGGGT; match class: 1 | 101 | 2.963740e-03 | 1 |
| TF | TF:M12642_1 | Factor: NFYA; motif: NNRGCCAATSRGMRSSNNSN; match class: 1 | Factor: NFYA; motif: NNRGCCAATSRGMRSSNNSN; match class: 1 | 23 | 3.024104e-03 | 1 |
| TF | TF:M10072_1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | 120 | 3.075927e-03 | 1 |
| TF | TF:M12173_1 | Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 | Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 | 101 | 3.079685e-03 | 1 |
| TF | TF:M12597_1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | 169 | 3.102189e-03 | 1 |
| TF | TF:M00739 | Factor: E2F-4:DP-2; motif: TTTCSCGC | Factor: E2F-4:DP-2; motif: TTTCSCGC | 110 | 3.133602e-03 | 1 |
| TF | TF:M03807 | Factor: SP2; motif: GNNGGGGGCGGGGSN | Factor: SP2; motif: GNNGGGGGCGGGGSN | 150 | 3.209290e-03 | 1 |
| TF | TF:M00932 | Factor: Sp1; motif: NNGGGGCGGGGNN | Factor: Sp1; motif: NNGGGGCGGGGNN | 176 | 3.253735e-03 | 1 |
| TF | TF:M09895_1 | Factor: E2F-6; motif: NGGGCGGGARRNN; match class: 1 | Factor: E2F-6; motif: NGGGCGGGARRNN; match class: 1 | 65 | 3.898961e-03 | 1 |
| TF | TF:M02071 | Factor: ETV7; motif: NCCGGAANNN | Factor: ETV7; motif: NCCGGAANNN | 171 | 4.075022e-03 | 1 |
| TF | TF:M02065 | Factor: ER81; motif: RCCGGAARYN | Factor: ER81; motif: RCCGGAARYN | 203 | 4.458457e-03 | 1 |
| TF | TF:M11430 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 180 | 4.478570e-03 | 1 |
| TF | TF:M07277 | Factor: BTEB2; motif: RGGGNGKGGN | Factor: BTEB2; motif: RGGGNGKGGN | 150 | 5.482842e-03 | 1 |
| TF | TF:M01240 | Factor: BEN; motif: CAGCGRNV | Factor: BEN; motif: CAGCGRNV | 242 | 5.596035e-03 | 1 |
| TF | TF:M12351 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC | 197 | 5.838386e-03 | 1 |
| TF | TF:M09892 | Factor: E2F-1; motif: NNNNGGCGGGAARN | Factor: E2F-1; motif: NNNNGGCGGGAARN | 212 | 5.866603e-03 | 1 |
| TF | TF:M04823 | Factor: E2F-4; motif: NNTTCCCGCCNN | Factor: E2F-4; motif: NNTTCCCGCCNN | 203 | 5.968577e-03 | 1 |
| TF | TF:M11529 | Factor: E2F-2; motif: GCGCGCGCNCS | Factor: E2F-2; motif: GCGCGCGCNCS | 240 | 7.359193e-03 | 1 |
| TF | TF:M11541_1 | Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN; match class: 1 | Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN; match class: 1 | 107 | 7.796301e-03 | 1 |
| TF | TF:M12592 | Factor: CREM; motif: NRTGACGYMA | Factor: CREM; motif: NRTGACGYMA | 120 | 7.925339e-03 | 1 |
| TF | TF:M01783_1 | Factor: SP2; motif: GGGCGGGAC; match class: 1 | Factor: SP2; motif: GGGCGGGAC; match class: 1 | 90 | 7.974555e-03 | 1 |
| TF | TF:M03922 | Factor: SP4; motif: NWRGCCACGCCCMCTYN | Factor: SP4; motif: NWRGCCACGCCCMCTYN | 115 | 8.399156e-03 | 1 |
| TF | TF:M12722 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS | 176 | 8.597781e-03 | 1 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 238 | 8.766337e-03 | 1 |
| TF | TF:M08911 | Factor: CTCF; motif: NCCRSTAGGGGGCGC | Factor: CTCF; motif: NCCRSTAGGGGGCGC | 157 | 9.665654e-03 | 1 |
| TF | TF:M12227_1 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 | 113 | 9.920793e-03 | 1 |
| TF | TF:M10530 | Factor: sp4; motif: NNNGCYCCGCCCCCY | Factor: sp4; motif: NNNGCYCCGCCCCCY | 145 | 1.005377e-02 | 1 |
| TF | TF:M00425 | Factor: E2F; motif: TTTCGCGC | Factor: E2F; motif: TTTCGCGC | 182 | 1.023054e-02 | 1 |
| TF | TF:M02065_1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | 128 | 1.023173e-02 | 1 |
| TF | TF:M00737_1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | 67 | 1.047140e-02 | 1 |
| TF | TF:M12554 | Factor: YY2; motif: NNATGGCGGCN | Factor: YY2; motif: NNATGGCGGCN | 62 | 1.055206e-02 | 1 |
| TF | TF:M08313 | Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR | Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR | 230 | 1.087013e-02 | 1 |
| TF | TF:M13135 | Factor: SP4; motif: GGCCCCGCCCCCN | Factor: SP4; motif: GGCCCCGCCCCCN | 108 | 1.096523e-02 | 1 |
| TF | TF:M03977_1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | 94 | 1.136416e-02 | 1 |
| TF | TF:M10098 | Factor: DP-1; motif: NRNNGGCGGGAANN | Factor: DP-1; motif: NRNNGGCGGGAANN | 129 | 1.157480e-02 | 1 |
| TF | TF:M12616_1 | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS; match class: 1 | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS; match class: 1 | 22 | 1.211141e-02 | 1 |
| TF | TF:M08209_1 | Factor: E2F-3:FOXO6; motif: NAATGACACGCGCCCMC; match class: 1 | Factor: E2F-3:FOXO6; motif: NAATGACACGCGCCCMC; match class: 1 | 139 | 1.213870e-02 | 1 |
| TF | TF:M00024_1 | Factor: E2F-1; motif: TWSGCGCGAAAAYKR; match class: 1 | Factor: E2F-1; motif: TWSGCGCGAAAAYKR; match class: 1 | 62 | 1.219354e-02 | 1 |
| TF | TF:M00931_1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | 113 | 1.226885e-02 | 1 |
| TF | TF:M12666 | Factor: SP1; motif: GGCCCCGCCCCCN | Factor: SP1; motif: GGCCCCGCCCCCN | 151 | 1.235289e-02 | 1 |
| TF | TF:M07084 | Factor: E2F-4; motif: NGGCGGGAARN | Factor: E2F-4; motif: NGGCGGGAARN | 179 | 1.255356e-02 | 1 |
| TF | TF:M11541 | Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN | Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN | 110 | 1.268628e-02 | 1 |
| TF | TF:M12666_1 | Factor: SP1; motif: GGCCCCGCCCCCN; match class: 1 | Factor: SP1; motif: GGCCCCGCCCCCN; match class: 1 | 90 | 1.276604e-02 | 1 |
| TF | TF:M02070 | Factor: TEL1; motif: CNCGGAANNN | Factor: TEL1; motif: CNCGGAANNN | 178 | 1.345946e-02 | 1 |
| TF | TF:M11533_1 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN; match class: 1 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN; match class: 1 | 151 | 1.353039e-02 | 1 |
| TF | TF:M04826 | Factor: p300; motif: ACNTCCG | Factor: p300; motif: ACNTCCG | 252 | 1.414610e-02 | 1 |
| TF | TF:M11022 | Factor: IRX2a; motif: ACRYGNNNNACRYGT | Factor: IRX2a; motif: ACRYGNNNNACRYGT | 161 | 1.441549e-02 | 1 |
| TF | TF:M00245_1 | Factor: Egr-3; motif: NTGCGTGGGCGK; match class: 1 | Factor: Egr-3; motif: NTGCGTGGGCGK; match class: 1 | 57 | 1.509720e-02 | 1 |
| TF | TF:M02052 | Factor: EHF; motif: CSCGGAARTN | Factor: EHF; motif: CSCGGAARTN | 168 | 1.538885e-02 | 1 |
| TF | TF:M13031 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 177 | 1.609213e-02 | 1 |
| TF | TF:M01820 | Factor: CREM; motif: TGACGTCASYN | Factor: CREM; motif: TGACGTCASYN | 117 | 1.622208e-02 | 1 |
| TF | TF:M00695_1 | Factor: ETF; motif: GVGGMGG; match class: 1 | Factor: ETF; motif: GVGGMGG; match class: 1 | 128 | 1.626824e-02 | 1 |
| TF | TF:M11528_1 | Factor: E2F-2; motif: NTTTTGGCGCCAWWWN; match class: 1 | Factor: E2F-2; motif: NTTTTGGCGCCAWWWN; match class: 1 | 95 | 1.684732e-02 | 1 |
| TF | TF:M04516 | Factor: E2F-1; motif: TTTGGCGCCAAA | Factor: E2F-1; motif: TTTGGCGCCAAA | 185 | 1.705742e-02 | 1 |
| TF | TF:M13144 | Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS | Factor: ZNF138; motif: GCAGCRSCNSGSNCMGSGCS | 160 | 1.775103e-02 | 1 |
| TF | TF:M07395 | Factor: Sp1; motif: NGGGGCGGGGN | Factor: Sp1; motif: NGGGGCGGGGN | 176 | 1.822805e-02 | 1 |
| TF | TF:M12152 | Factor: Sp1; motif: NWRGCCACGCCCMCN | Factor: Sp1; motif: NWRGCCACGCCCMCN | 132 | 1.838848e-02 | 1 |
| TF | TF:M11529_1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | 221 | 1.878965e-02 | 1 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 244 | 1.961892e-02 | 1 |
| TF | TF:M04106_1 | Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 | Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 | 146 | 2.144103e-02 | 1 |
| TF | TF:M00428_1 | Factor: E2F-1; motif: NKTSSCGC; match class: 1 | Factor: E2F-1; motif: NKTSSCGC; match class: 1 | 77 | 2.156826e-02 | 1 |
| TF | TF:M11396_1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | 97 | 2.160509e-02 | 1 |
| TF | TF:M08226_1 | Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 | Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 | 107 | 2.180273e-02 | 1 |
| TF | TF:M11533 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN | 205 | 2.214204e-02 | 1 |
| TF | TF:M04953 | Factor: Sp1; motif: GGNDGGRGGCGGGG | Factor: Sp1; motif: GGNDGGRGGCGGGG | 150 | 2.240654e-02 | 1 |
| TF | TF:M11535 | Factor: E2F-4; motif: TTTTGGCGCCAWWN | Factor: E2F-4; motif: TTTTGGCGCCAWWN | 178 | 2.418044e-02 | 1 |
| TF | TF:M12616 | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS | 64 | 2.456956e-02 | 1 |
| TF | TF:M00196_1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | 112 | 2.513237e-02 | 1 |
| TF | TF:M00004_1 | Factor: c-Myb; motif: NCNRNNGRCNGTTGGKGG; match class: 1 | Factor: c-Myb; motif: NCNRNNGRCNGTTGGKGG; match class: 1 | 47 | 2.564993e-02 | 1 |
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 228 | 2.781555e-02 | 1 |
| TF | TF:M00986 | Factor: Churchill; motif: CGGGNN | Factor: Churchill; motif: CGGGNN | 217 | 2.834710e-02 | 1 |
| TF | TF:M09636_1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | 216 | 3.067121e-02 | 1 |
| TF | TF:M08309_1 | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN; match class: 1 | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN; match class: 1 | 127 | 3.098895e-02 | 1 |
| TF | TF:M12597 | Factor: E2F1; motif: GSGCGGGAAN | Factor: E2F1; motif: GSGCGGGAAN | 215 | 3.183161e-02 | 1 |
| TF | TF:M07302 | Factor: NF-Y; motif: RGCCAATCRGN | Factor: NF-Y; motif: RGCCAATCRGN | 42 | 3.307045e-02 | 1 |
| TF | TF:M10071 | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG | 147 | 3.517451e-02 | 1 |
| TF | TF:M00025 | Factor: Elk-1; motif: NNNNCCGGAARTNN | Factor: Elk-1; motif: NNNNCCGGAARTNN | 166 | 3.581051e-02 | 1 |
| TF | TF:M01588 | Factor: GKLF; motif: GCCMCRCCCNNN | Factor: GKLF; motif: GCCMCRCCCNNN | 152 | 3.731228e-02 | 1 |
| TF | TF:M13124 | Factor: ZNF670; motif: SNGGGCRGRG | Factor: ZNF670; motif: SNGGGCRGRG | 200 | 3.766887e-02 | 1 |
| TF | TF:M12590 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN | 179 | 3.812471e-02 | 1 |
| TF | TF:M04691_1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | 172 | 3.853635e-02 | 1 |
| TF | TF:M11603_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 205 | 3.858721e-02 | 1 |
| TF | TF:M11530_1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | 208 | 3.871444e-02 | 1 |
| TF | TF:M10006 | Factor: NF-YC; motif: NNRRCCAATCAGNR | Factor: NF-YC; motif: NNRRCCAATCAGNR | 58 | 3.885948e-02 | 1 |
| TF | TF:M02064 | Factor: c-ets-2; motif: ACCGGAWRTN | Factor: c-ets-2; motif: ACCGGAWRTN | 177 | 3.963988e-02 | 1 |
| TF | TF:M03920 | Factor: SP1; motif: RCCMCRCCCMC | Factor: SP1; motif: RCCMCRCCCMC | 130 | 4.029183e-02 | 1 |
| TF | TF:M08309 | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN | 199 | 4.226398e-02 | 1 |
| TF | TF:M00025_1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | 88 | 4.341825e-02 | 1 |
| TF | TF:M02036 | Factor: WT1; motif: CGCCCCCNCN | Factor: WT1; motif: CGCCCCCNCN | 163 | 4.539554e-02 | 1 |
| TF | TF:M09895 | Factor: E2F-6; motif: NGGGCGGGARRNN | Factor: E2F-6; motif: NGGGCGGGARRNN | 137 | 4.683390e-02 | 1 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1474 | SMAD3/4-E2F4/5-p107-DP1 complex | SMAD3/4-E2F4/5-p107-DP1 complex | 6 | 6.821518e-07 | 1 |
| CORUM | CORUM:433 | BASC complex (BRCA1-associated genome surveillance complex) | BASC complex (BRCA1-associated genome surveillance complex) | 7 | 1.698594e-05 | 1 |
| CORUM | CORUM:2975 | SMAD3-E2F4/5-p107-DP1 complex | SMAD3-E2F4/5-p107-DP1 complex | 5 | 1.828816e-05 | 1 |
| CORUM | CORUM:1005 | RC complex during G2/M-phase of cell cycle | RC complex during G2/M-phase of cell cycle | 6 | 1.259296e-04 | 1 |
| CORUM | CORUM:1030 | CAK-ERCC2 complex | CAK-ERCC2 complex | 4 | 4.865804e-04 | 1 |
| CORUM | CORUM:2660 | CAK-ERCC2 complex | CAK-ERCC2 complex | 4 | 4.865804e-04 | 1 |
| CORUM | CORUM:2210 | BRCA1-IRIS-pre-replication complex | BRCA1-IRIS-pre-replication complex | 4 | 4.865804e-04 | 1 |
| CORUM | CORUM:202 | BRCA1-RAD50-MRE11-NBS1 complex | BRCA1-RAD50-MRE11-NBS1 complex | 4 | 4.865804e-04 | 1 |
| CORUM | CORUM:964 | BRCA1-RAD50-MRE11-NBS1 complex | BRCA1-RAD50-MRE11-NBS1 complex | 4 | 4.865804e-04 | 1 |
| CORUM | CORUM:310 | Cell cycle kinase complex CDC2 | Cell cycle kinase complex CDC2 | 4 | 4.865804e-04 | 1 |
| CORUM | CORUM:1003 | RC complex (Replication competent complex) | RC complex (Replication competent complex) | 5 | 9.316335e-04 | 1 |
| CORUM | CORUM:2815 | BRCA1-BARD1-BACH1-DNA damage complex II | BRCA1-BARD1-BACH1-DNA damage complex II | 5 | 9.316335e-04 | 1 |
| CORUM | CORUM:1004 | RC complex during S-phase of cell cycle | RC complex during S-phase of cell cycle | 5 | 2.031150e-03 | 1 |
| CORUM | CORUM:1107 | DNA synthesome core complex | DNA synthesome core complex | 5 | 2.031150e-03 | 1 |
| CORUM | CORUM:1098 | DNA synthesome complex (13 subunits) | DNA synthesome complex (13 subunits) | 5 | 3.936371e-03 | 1 |
| CORUM | CORUM:5596 | LINC complex, quiescent cells | LINC complex, quiescent cells | 4 | 6.866611e-03 | 1 |
| CORUM | CORUM:3015 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | 4 | 6.866611e-03 | 1 |
| CORUM | CORUM:5118 | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) | 4 | 6.866611e-03 | 1 |
| CORUM | CORUM:313 | Cell cycle kinase complex CDK5 | Cell cycle kinase complex CDK5 | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:71 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:331 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:618 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:5144 | E2F1-p107-cyclinA complex | E2F1-p107-cyclinA complex | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:2706 | SMAD3-SMAD4-SP1 complex | SMAD3-SMAD4-SP1 complex | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:2834 | SMAD4-SMAD2-SMAD3 complex | SMAD4-SMAD2-SMAD3 complex | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:2818 | BRCA1-BARD1-BRCA2-DNA damage complex III | BRCA1-BARD1-BRCA2-DNA damage complex III | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:3754 | CREBBP-SMAD3-SMAD4 pentameric complex | CREBBP-SMAD3-SMAD4 pentameric complex | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:3753 | CREBBP-SMAD2-SMAD4 pentameric complex | CREBBP-SMAD2-SMAD4 pentameric complex | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:6589 | E2F-1-DP-1-cyclinA-CDK2 complex | E2F-1-DP-1-cyclinA-CDK2 complex | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:6300 | CDKN1A-TP53-CDK1-PCNA complex | CDKN1A-TP53-CDK1-PCNA complex | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:1010 | CAK complex (Cdk-activating kinase complex) | CAK complex (Cdk-activating kinase complex) | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:173 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:1008 | CAK complex (Cdk-activating kinase complex) | CAK complex (Cdk-activating kinase complex) | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:972 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:73 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:2767 | RAD50-MRE11-NBN-p200-p350 complex | RAD50-MRE11-NBN-p200-p350 complex | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:1661 | E2F4-p107-cyclinA complex | E2F4-p107-cyclinA complex | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:1473 | E2F5-RB2-DP1 complex | E2F5-RB2-DP1 complex | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:1173 | TIP49-TIP48-BAF53 complex | TIP49-TIP48-BAF53 complex | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:1081 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284876e-02 | 1 |
| CORUM | CORUM:1108 | DNA synthesome complex (15 subunits) | DNA synthesome complex (15 subunits) | 5 | 1.829381e-02 | 1 |
| CORUM | CORUM:1099 | DNA synthesome complex (17 subunits) | DNA synthesome complex (17 subunits) | 5 | 2.757737e-02 | 1 |
| CORUM | CORUM:1111 | DNA synthesome complex (17 subunits) | DNA synthesome complex (17 subunits) | 5 | 2.757737e-02 | 1 |
| CORUM | CORUM:434 | BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) | BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) | 4 | 3.015107e-02 | 1 |
| CORUM | CORUM:2218 | MDC1-MRE11-RAD50-NBS1 complex | MDC1-MRE11-RAD50-NBS1 complex | 3 | 4.993531e-02 | 1 |
| CORUM | CORUM:4 | Multisubunit ACTR coactivator complex | Multisubunit ACTR coactivator complex | 3 | 4.993531e-02 | 1 |
| CORUM | CORUM:1827 | PML-SMAD2/3-SARA complex | PML-SMAD2/3-SARA complex | 3 | 4.993531e-02 | 1 |
| CORUM | CORUM:619 | MRE11A-RAD50-NBN-TRF2 complex | MRE11A-RAD50-NBN-TRF2 complex | 3 | 4.993531e-02 | 1 |
| CORUM | CORUM:627 | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) | 3 | 4.993531e-02 | 1 |
Community 2
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002181 | cytoplasmic translation | "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] | 74 | 3.098548e-128 | 2 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 88 | 1.133791e-99 | 2 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 98 | 5.780127e-40 | 2 |
| GO:BP | GO:0042254 | ribosome biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] | 40 | 1.638252e-39 | 2 |
| GO:BP | GO:0042274 | ribosomal small subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 24 | 3.447235e-29 | 2 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 107 | 3.539089e-22 | 2 |
| GO:BP | GO:0006364 | rRNA processing | "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] | 24 | 1.114576e-20 | 2 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 107 | 2.657273e-20 | 2 |
| GO:BP | GO:0016072 | rRNA metabolic process | "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] | 25 | 2.835047e-20 | 2 |
| GO:BP | GO:0022613 | ribonucleoprotein complex biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] | 48 | 3.238708e-17 | 2 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 108 | 4.891183e-17 | 2 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 114 | 1.177664e-16 | 2 |
| GO:BP | GO:0042255 | ribosome assembly | "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428] | 14 | 9.082288e-16 | 2 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 112 | 1.208094e-15 | 2 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 23 | 3.942384e-14 | 2 |
| GO:BP | GO:0006413 | translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] | 15 | 1.064245e-12 | 2 |
| GO:BP | GO:0042273 | ribosomal large subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 12 | 9.445197e-12 | 2 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 21 | 7.772200e-11 | 2 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 114 | 1.702538e-10 | 2 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 37 | 9.962184e-09 | 2 |
| GO:BP | GO:0045727 | positive regulation of translation | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] | 12 | 3.909951e-08 | 2 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 61 | 1.661670e-07 | 2 |
| GO:BP | GO:1901798 | positive regulation of signal transduction by p53 class mediator | "Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 7 | 3.054523e-07 | 2 |
| GO:BP | GO:0002183 | cytoplasmic translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] | 8 | 3.336032e-07 | 2 |
| GO:BP | GO:0001732 | formation of cytoplasmic translation initiation complex | "Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd, PMID:29735639] | 6 | 4.014090e-07 | 2 |
| GO:BP | GO:0000027 | ribosomal large subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428] | 6 | 6.500083e-06 | 2 |
| GO:BP | GO:0030490 | maturation of SSU-rRNA | "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators] | 7 | 3.534795e-05 | 2 |
| GO:BP | GO:0000028 | ribosomal small subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl, PMID:30467428] | 5 | 7.750774e-05 | 2 |
| GO:BP | GO:0010608 | post-transcriptional regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] | 23 | 7.873857e-05 | 2 |
| GO:BP | GO:0070925 | organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 22 | 1.768813e-04 | 2 |
| GO:BP | GO:1901796 | regulation of signal transduction by p53 class mediator | "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 8 | 2.900948e-04 | 2 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 17 | 5.248875e-04 | 2 |
| GO:BP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 9 | 9.987160e-04 | 2 |
| GO:BP | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 6 | 1.212044e-03 | 2 |
| GO:BP | GO:0017148 | negative regulation of translation | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 8 | 1.566015e-03 | 2 |
| GO:BP | GO:0034063 | stress granule assembly | "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519] | 5 | 2.340016e-03 | 2 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 20 | 2.892824e-03 | 2 |
| GO:BP | GO:2000767 | positive regulation of cytoplasmic translation | "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 4 | 3.002607e-03 | 2 |
| GO:BP | GO:0051438 | regulation of ubiquitin-protein transferase activity | "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] | 5 | 4.144884e-03 | 2 |
| GO:BP | GO:1903051 | negative regulation of proteolysis involved in protein catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 6 | 6.546526e-03 | 2 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 8 | 7.975847e-03 | 2 |
| GO:BP | GO:0010628 | positive regulation of gene expression | "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 21 | 8.071409e-03 | 2 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 57 | 8.732772e-03 | 2 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 19 | 1.153965e-02 | 2 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 11 | 1.237387e-02 | 2 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 8 | 1.398655e-02 | 2 |
| GO:BP | GO:1903050 | regulation of proteolysis involved in protein catabolic process | "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 9 | 1.485148e-02 | 2 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 9 | 1.643620e-02 | 2 |
| GO:BP | GO:0032071 | regulation of endodeoxyribonuclease activity | "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] | 3 | 1.714289e-02 | 2 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 9 | 1.939903e-02 | 2 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 11 | 2.002238e-02 | 2 |
| GO:BP | GO:0000470 | maturation of LSU-rRNA | "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators] | 4 | 2.005699e-02 | 2 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 8 | 3.046097e-02 | 2 |
| GO:BP | GO:1904667 | negative regulation of ubiquitin protein ligase activity | "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:tb, GOC:TermGenie, PMID:26216882] | 3 | 3.642914e-02 | 2 |
| GO:BP | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 5 | 4.080294e-02 | 2 |
| GO:BP | GO:0051338 | regulation of transferase activity | "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] | 12 | 4.896494e-02 | 2 |
| GO:BP | GO:0070934 | CRD-mediated mRNA stabilization | "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303] | 3 | 4.988135e-02 | 2 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0022626 | cytosolic ribosome | "A ribosome located in the cytosol." [GOC:mtg_sensu] | 66 | 1.158800e-124 | 2 |
| GO:CC | GO:0044391 | ribosomal subunit | "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl] | 67 | 1.595945e-108 | 2 |
| GO:CC | GO:0005840 | ribosome | "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] | 69 | 1.907220e-78 | 2 |
| GO:CC | GO:0022625 | cytosolic large ribosomal subunit | "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 34 | 1.145826e-62 | 2 |
| GO:CC | GO:0022627 | cytosolic small ribosomal subunit | "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 31 | 9.596297e-61 | 2 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 88 | 1.683029e-51 | 2 |
| GO:CC | GO:0015935 | small ribosomal subunit | "The smaller of the two subunits of a ribosome." [GOC:mah] | 32 | 2.141063e-51 | 2 |
| GO:CC | GO:0015934 | large ribosomal subunit | "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] | 35 | 1.172743e-50 | 2 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 106 | 2.558811e-46 | 2 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 101 | 2.872170e-32 | 2 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 101 | 2.912805e-32 | 2 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 37 | 5.613587e-32 | 2 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 37 | 1.325659e-31 | 2 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 107 | 1.466690e-31 | 2 |
| GO:CC | GO:0032040 | small-subunit processome | "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] | 22 | 1.073937e-30 | 2 |
| GO:CC | GO:0030684 | preribosome | "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] | 22 | 1.403911e-26 | 2 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 62 | 3.205168e-26 | 2 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 118 | 1.957314e-24 | 2 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 51 | 9.988930e-24 | 2 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 56 | 1.606932e-23 | 2 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 56 | 3.257652e-23 | 2 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 56 | 3.334638e-23 | 2 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 56 | 3.334638e-23 | 2 |
| GO:CC | GO:0005730 | nucleolus | "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] | 53 | 4.560318e-22 | 2 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 38 | 3.306204e-21 | 2 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 82 | 5.215866e-21 | 2 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 69 | 4.454960e-18 | 2 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 84 | 7.954092e-17 | 2 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 84 | 7.954092e-17 | 2 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 84 | 7.954092e-17 | 2 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 59 | 2.691181e-16 | 2 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 100 | 2.842425e-15 | 2 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 61 | 1.462007e-13 | 2 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 61 | 1.999307e-12 | 2 |
| GO:CC | GO:0005852 | eukaryotic translation initiation factor 3 complex | "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] | 8 | 2.089267e-12 | 2 |
| GO:CC | GO:0014069 | postsynaptic density | "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density] | 19 | 2.059455e-11 | 2 |
| GO:CC | GO:0032279 | asymmetric synapse | "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef] | 19 | 4.510641e-11 | 2 |
| GO:CC | GO:0099572 | postsynaptic specialization | "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028] | 19 | 1.249055e-10 | 2 |
| GO:CC | GO:0098984 | neuron to neuron synapse | "A synapse in which pre and post-synaptic cells are neurons." [GOC:dos] | 19 | 2.413121e-10 | 2 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 118 | 1.948761e-09 | 2 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 120 | 2.839862e-09 | 2 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 15 | 8.239961e-09 | 2 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 115 | 1.356974e-08 | 2 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 14 | 3.817414e-08 | 2 |
| GO:CC | GO:0033290 | eukaryotic 48S preinitiation complex | "The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC." [GOC:hjd, PMID:16510876, PMID:24319994, PMID:24499181, PMID:29735639] | 6 | 7.550922e-08 | 2 |
| GO:CC | GO:0016282 | eukaryotic 43S preinitiation complex | "A protein complex composed of the 40S ribosomal subunit plus eIF1, eIF1A, eIF3, eIF5, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049, PMID:16510876, PMID:25742741, PMID:29735639] | 6 | 1.127643e-07 | 2 |
| GO:CC | GO:0070993 | cytosolic translation preinitiation complex | "A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA." [GOC:hjd, GOC:mah] | 6 | 1.640825e-07 | 2 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 21 | 3.422782e-07 | 2 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 112 | 4.060322e-07 | 2 |
| GO:CC | GO:0005791 | rough endoplasmic reticulum | "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] | 7 | 1.130050e-05 | 2 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 83 | 1.912719e-05 | 2 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 105 | 3.244007e-05 | 2 |
| GO:CC | GO:0098556 | cytoplasmic side of rough endoplasmic reticulum membrane | "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm." [GOC:ab, GOC:dos] | 3 | 8.808174e-04 | 2 |
| GO:CC | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m | "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185] | 3 | 1.535327e-03 | 2 |
| GO:CC | GO:0010494 | cytoplasmic stress granule | "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] | 6 | 3.326085e-03 | 2 |
| GO:CC | GO:0071540 | eukaryotic translation initiation factor 3 complex, eIF3e | "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e." [PMID:15904532, PMID:19061185] | 2 | 8.364892e-03 | 2 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 6 | 1.700258e-02 | 2 |
| GO:CC | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex | "A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein." [GOC:bf, GOC:PARL, PMID:12628165] | 2 | 2.500554e-02 | 2 |
| GO:CC | GO:0120259 | 7SK snRNP | "A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb." [PMID:18249148, PMID:28431135] | 2 | 2.500554e-02 | 2 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 20 | 2.801610e-02 | 2 |
| GO:CC | GO:0005783 | endoplasmic reticulum | "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] | 25 | 3.599890e-02 | 2 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | L13a-mediated translational silencing of Ceruloplasmin expression | 71 | 3.900077e-123 | 2 |
| REAC | REAC:R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | GTP hydrolysis and joining of the 60S ribosomal subunit | 70 | 4.932859e-120 | 2 |
| REAC | REAC:R-HSA-72737 | Cap-dependent Translation Initiation | Cap-dependent Translation Initiation | 71 | 7.074108e-120 | 2 |
| REAC | REAC:R-HSA-72613 | Eukaryotic Translation Initiation | Eukaryotic Translation Initiation | 71 | 7.074108e-120 | 2 |
| REAC | REAC:R-HSA-72689 | Formation of a pool of free 40S subunits | Formation of a pool of free 40S subunits | 68 | 1.651149e-119 | 2 |
| REAC | REAC:R-HSA-156902 | Peptide chain elongation | Peptide chain elongation | 64 | 1.636089e-114 | 2 |
| REAC | REAC:R-HSA-156842 | Eukaryotic Translation Elongation | Eukaryotic Translation Elongation | 64 | 1.791826e-112 | 2 |
| REAC | REAC:R-HSA-192823 | Viral mRNA Translation | Viral mRNA Translation | 62 | 4.981594e-109 | 2 |
| REAC | REAC:R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 63 | 7.652939e-109 | 2 |
| REAC | REAC:R-HSA-72764 | Eukaryotic Translation Termination | Eukaryotic Translation Termination | 62 | 4.154860e-107 | 2 |
| REAC | REAC:R-HSA-2408557 | Selenocysteine synthesis | Selenocysteine synthesis | 62 | 4.154860e-107 | 2 |
| REAC | REAC:R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Response of EIF2AK4 (GCN2) to amino acid deficiency | 63 | 3.082325e-106 | 2 |
| REAC | REAC:R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 63 | 4.902806e-101 | 2 |
| REAC | REAC:R-HSA-927802 | Nonsense-Mediated Decay (NMD) | Nonsense-Mediated Decay (NMD) | 63 | 4.902806e-101 | 2 |
| REAC | REAC:R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | SRP-dependent cotranslational protein targeting to membrane | 62 | 1.336316e-99 | 2 |
| REAC | REAC:R-HSA-2408522 | Selenoamino acid metabolism | Selenoamino acid metabolism | 62 | 2.856828e-98 | 2 |
| REAC | REAC:R-HSA-168273 | Influenza Viral RNA Transcription and Replication | Influenza Viral RNA Transcription and Replication | 62 | 1.494646e-93 | 2 |
| REAC | REAC:R-HSA-72766 | Translation | Translation | 75 | 3.535212e-93 | 2 |
| REAC | REAC:R-HSA-9711097 | Cellular response to starvation | Cellular response to starvation | 63 | 5.635938e-90 | 2 |
| REAC | REAC:R-HSA-8868773 | rRNA processing in the nucleus and cytosol | rRNA processing in the nucleus and cytosol | 66 | 1.680151e-89 | 2 |
| REAC | REAC:R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Major pathway of rRNA processing in the nucleolus and cytosol | 65 | 3.218716e-89 | 2 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 64 | 3.252242e-89 | 2 |
| REAC | REAC:R-HSA-168255 | Influenza Infection | Influenza Infection | 62 | 1.944855e-88 | 2 |
| REAC | REAC:R-HSA-72312 | rRNA processing | rRNA processing | 66 | 9.455540e-88 | 2 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 64 | 2.896170e-81 | 2 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 62 | 6.648185e-62 | 2 |
| REAC | REAC:R-HSA-72649 | Translation initiation complex formation | Translation initiation complex formation | 38 | 6.738105e-62 | 2 |
| REAC | REAC:R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 38 | 1.826215e-61 | 2 |
| REAC | REAC:R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Formation of the ternary complex, and subsequently, the 43S complex | 36 | 3.257573e-60 | 2 |
| REAC | REAC:R-HSA-72702 | Ribosomal scanning and start codon recognition | Ribosomal scanning and start codon recognition | 37 | 1.783226e-59 | 2 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 72 | 1.974450e-57 | 2 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 66 | 1.459818e-56 | 2 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 66 | 3.115326e-55 | 2 |
| REAC | REAC:R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | SARS-CoV-1 modulates host translation machinery | 30 | 3.222498e-53 | 2 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 68 | 3.634076e-48 | 2 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 70 | 3.838281e-48 | 2 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 68 | 1.187281e-47 | 2 |
| REAC | REAC:R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | SARS-CoV-2 modulates host translation machinery | 29 | 6.107738e-44 | 2 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 71 | 1.543234e-43 | 2 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 31 | 1.492250e-37 | 2 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 83 | 8.872243e-37 | 2 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 68 | 2.711824e-32 | 2 |
| REAC | REAC:R-HSA-9678108 | SARS-CoV-1 Infection | SARS-CoV-1 Infection | 31 | 1.254563e-31 | 2 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 74 | 1.881250e-30 | 2 |
| REAC | REAC:R-HSA-9705683 | SARS-CoV-2-host interactions | SARS-CoV-2-host interactions | 31 | 1.009393e-26 | 2 |
| REAC | REAC:R-HSA-9694516 | SARS-CoV-2 Infection | SARS-CoV-2 Infection | 31 | 2.407619e-21 | 2 |
| REAC | REAC:R-HSA-1430728 | Metabolism | Metabolism | 66 | 2.417372e-19 | 2 |
| REAC | REAC:R-HSA-9679506 | SARS-CoV Infections | SARS-CoV Infections | 34 | 1.385653e-18 | 2 |
| REAC | REAC:R-HSA-6790901 | rRNA modification in the nucleus and cytosol | rRNA modification in the nucleus and cytosol | 8 | 4.621283e-05 | 2 |
| REAC | REAC:R-HSA-9629569 | Protein hydroxylation | Protein hydroxylation | 4 | 1.793708e-02 | 2 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP477 | Cytoplasmic ribosomal proteins | Cytoplasmic ribosomal proteins | 61 | 1.689491e-103 | 2 |
| WP | WP:WP107 | Translation factors | Translation factors | 11 | 1.721520e-09 | 2 |
| WP | WP:WP5027 | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell | 7 | 5.172987e-08 | 2 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03010 | Ribosome | Ribosome | 63 | 2.253651e-93 | 2 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | Coronavirus disease - COVID-19 | 62 | 1.108444e-77 | 2 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:306 | Ribosome, cytoplasmic | Ribosome, cytoplasmic | 56 | 1.925314e-78 | 2 |
| CORUM | CORUM:3055 | Nop56p-associated pre-rRNA complex | Nop56p-associated pre-rRNA complex | 48 | 2.948739e-53 | 2 |
| CORUM | CORUM:305 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 27 | 6.642541e-38 | 2 |
| CORUM | CORUM:338 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 26 | 3.995189e-37 | 2 |
| CORUM | CORUM:308 | 60S ribosomal subunit, cytoplasmic | 60S ribosomal subunit, cytoplasmic | 29 | 5.098462e-35 | 2 |
| CORUM | CORUM:5380 | TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) | TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) | 12 | 5.050410e-12 | 2 |
| CORUM | CORUM:742 | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) | 6 | 7.405996e-05 | 2 |
| CORUM | CORUM:1097 | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) | 6 | 1.345415e-04 | 2 |
| CORUM | CORUM:5266 | TNF-alpha/NF-kappa B signaling complex 6 | TNF-alpha/NF-kappa B signaling complex 6 | 5 | 3.844423e-03 | 2 |
| CORUM | CORUM:219 | CAND1-CUL1-RBX1 complex | CAND1-CUL1-RBX1 complex | 3 | 5.180398e-03 | 2 |
| CORUM | CORUM:1215 | Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) | Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) | 3 | 2.031237e-02 | 2 |
| CORUM | CORUM:2719 | Casein kinase II-HMG1 complex | Casein kinase II-HMG1 complex | 3 | 2.031237e-02 | 2 |
| CORUM | CORUM:1253 | Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) | Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) | 3 | 2.031237e-02 | 2 |
| CORUM | CORUM:4403 | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J) | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J) | 3 | 4.977919e-02 | 2 |
| CORUM | CORUM:4392 | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) | 3 | 4.977919e-02 | 2 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003735 | structural constituent of ribosome | "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] | 63 | 9.503059e-70 | 2 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 98 | 2.474296e-56 | 2 |
| GO:MF | GO:0005198 | structural molecule activity | "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] | 64 | 5.109811e-46 | 2 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 101 | 8.641140e-37 | 2 |
| GO:MF | GO:0019843 | rRNA binding | "Binding to a ribosomal RNA." [GOC:jl] | 16 | 4.457576e-19 | 2 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 26 | 1.439842e-17 | 2 |
| GO:MF | GO:0180051 | translation factor activity | "A molecular function required for translation of a mRNA into a protein functioning as part of initiation, elongation or termination of translation." [GOC:pg] | 11 | 3.007047e-09 | 2 |
| GO:MF | GO:0003743 | translation initiation factor activity | "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] | 9 | 1.128917e-08 | 2 |
| GO:MF | GO:0048027 | mRNA 5'-UTR binding | "Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid] | 7 | 3.264171e-08 | 2 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 115 | 2.654240e-07 | 2 |
| GO:MF | GO:1990948 | ubiquitin ligase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a ubiquitin ligase." [GOC:dph, GOC:vw, PMID:21389117] | 5 | 7.882248e-07 | 2 |
| GO:MF | GO:0055105 | ubiquitin-protein transferase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase." [GOC:BHF, GOC:rl] | 5 | 6.144327e-06 | 2 |
| GO:MF | GO:0055106 | ubiquitin-protein transferase regulator activity | "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl] | 6 | 1.768827e-05 | 2 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 13 | 4.700734e-05 | 2 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 33 | 5.793579e-05 | 2 |
| GO:MF | GO:0045182 | translation regulator activity | "Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai] | 6 | 8.535129e-04 | 2 |
| GO:MF | GO:0070180 | large ribosomal subunit rRNA binding | "Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh] | 3 | 9.586602e-04 | 2 |
| GO:MF | GO:0097100 | supercoiled DNA binding | "Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA." [GOC:pr, GOC:rph, PMID:20723754, PMID:21345933, Wikipedia:DNA_supercoil] | 3 | 9.586602e-04 | 2 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 14 | 3.062785e-03 | 2 |
| GO:MF | GO:0003727 | single-stranded RNA binding | "Binding to single-stranded RNA." [GOC:jl] | 6 | 5.435097e-03 | 2 |
| GO:MF | GO:0097322 | 7SK snRNA binding | "Binding to a 7SK small nuclear RNA (7SK snRNA)." [GOC:nhn, PMID:21853533] | 3 | 7.914143e-03 | 2 |
| GO:MF | GO:0003730 | mRNA 3'-UTR binding | "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] | 6 | 2.882661e-02 | 2 |
| GO:MF | GO:0043021 | ribonucleoprotein complex binding | "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] | 7 | 3.845914e-02 | 2 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 6 | 4.204342e-02 | 2 |
| GO:MF | GO:0000217 | DNA secondary structure binding | "Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction." [GOC:krc] | 4 | 4.331102e-02 | 2 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0012133 | Erythroid hypoplasia | Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 18 | 3.063779e-30 | 2 |
| HP | HP:0020118 | Radial artery aplasia | Congenital absence of the radial artery. | 17 | 1.251651e-29 | 2 |
| HP | HP:0031640 | Abnormal radial artery morphology | Any structural anomaly of the radial artery. | 17 | 1.251651e-29 | 2 |
| HP | HP:0030270 | Elevated red cell adenosine deaminase activity | Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine. | 17 | 1.251651e-29 | 2 |
| HP | HP:4000209 | Abnormal erythrocyte adenosine deaminase activity | Activity of adenosine deaminase in red blood cells outside the limits of normal. | 17 | 3.367460e-29 | 2 |
| HP | HP:0005532 | Macrocytic dyserythropoietic anemia | Macrocytic dyserythropoietic anemia | 17 | 8.541283e-29 | 2 |
| HP | HP:0002669 | Osteosarcoma | A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor. | 18 | 2.572413e-28 | 2 |
| HP | HP:0012410 | Pure red cell aplasia | A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction. | 17 | 4.729634e-28 | 2 |
| HP | HP:0040276 | Adenocarcinoma of the colon | Adenocarcinoma of the colon | 17 | 1.760391e-26 | 2 |
| HP | HP:0001227 | Abnormality of the thenar eminence | An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb. | 17 | 1.760391e-26 | 2 |
| HP | HP:0006758 | Malignant genitourinary tract tumor | The presence of a malignant neoplasm of the genital system. | 17 | 3.323618e-26 | 2 |
| HP | HP:0001896 | Reticulocytopenia | A reduced number of reticulocytes in the peripheral blood. | 17 | 6.126828e-26 | 2 |
| HP | HP:0011904 | Persistence of hemoglobin F | Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent. | 17 | 6.126828e-26 | 2 |
| HP | HP:0001895 | Normochromic anemia | Normochromic anemia | 17 | 1.951402e-25 | 2 |
| HP | HP:0040275 | Adenocarcinoma of the large intestine | A malignant epithelial tumor with a glandular organization that originates in the large intestine. | 17 | 1.951402e-25 | 2 |
| HP | HP:0012131 | Abnormal number of erythroid precursors | A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 18 | 5.903333e-25 | 2 |
| HP | HP:0009944 | Partial duplication of thumb phalanx | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 17 | 9.636428e-25 | 2 |
| HP | HP:0040273 | Adenocarcinoma of the intestines | A malignant epithelial tumor with a glandular organization that originates in the intestines. | 17 | 1.588043e-24 | 2 |
| HP | HP:0009999 | Partial duplication of the phalanx of hand | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 17 | 2.578708e-24 | 2 |
| HP | HP:0009777 | Absent thumb | Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues. | 18 | 6.099432e-24 | 2 |
| HP | HP:0004808 | Acute myeloid leukemia | A form of leukemia characterized by overproduction of an early myeloid cell. | 19 | 1.757695e-23 | 2 |
| HP | HP:0030272 | Abnormal erythrocyte enzyme concentration or activity | An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme. | 17 | 2.398663e-23 | 2 |
| HP | HP:0005518 | Increased mean corpuscular volume | Larger than normal size of erythrocytes. | 17 | 8.013070e-23 | 2 |
| HP | HP:0001894 | Thrombocytosis | Increased numbers of platelets in the peripheral blood. | 18 | 9.034675e-23 | 2 |
| HP | HP:0000912 | Sprengel anomaly | A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other). | 17 | 1.709468e-22 | 2 |
| HP | HP:0001972 | Macrocytic anemia | A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH). | 18 | 9.328163e-22 | 2 |
| HP | HP:0009942 | Duplication of thumb phalanx | Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits. | 17 | 1.374014e-21 | 2 |
| HP | HP:0000185 | Cleft soft palate | Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency. | 17 | 1.374014e-21 | 2 |
| HP | HP:0025065 | Abnormal mean corpuscular volume | A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters. | 17 | 2.605793e-21 | 2 |
| HP | HP:0001790 | Nonimmune hydrops fetalis | A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens . | 17 | 8.737875e-21 | 2 |
| HP | HP:0001199 | Triphalangeal thumb | A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb. | 17 | 2.697081e-20 | 2 |
| HP | HP:0002863 | Myelodysplasia | Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia. | 19 | 6.876386e-20 | 2 |
| HP | HP:0009380 | Finger aplasia | A developmental defect resulting in the presence of fewer than the normal number of fingers (i.e., aplasia of one or more fingers). | 18 | 7.089946e-20 | 2 |
| HP | HP:0001087 | Developmental glaucoma | Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma. | 17 | 9.978564e-20 | 2 |
| HP | HP:0006749 | Malignant gastrointestinal tract tumors | Malignant gastrointestinal tract tumors | 17 | 9.978564e-20 | 2 |
| HP | HP:0002672 | Gastrointestinal carcinoma | Gastrointestinal carcinoma | 17 | 9.978564e-20 | 2 |
| HP | HP:0011902 | Abnormal hemoglobin | Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes. | 17 | 1.637770e-19 | 2 |
| HP | HP:0002488 | Acute leukemia | A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts). | 19 | 1.963053e-19 | 2 |
| HP | HP:0100273 | Neoplasm of the colon | Neoplasm of the colon | 17 | 5.313897e-19 | 2 |
| HP | HP:0004312 | Abnormal reticulocyte morphology | A reticulocyte abnormality. | 17 | 8.318248e-19 | 2 |
| HP | HP:0010622 | Neoplasm of the skeletal system | A tumor (abnormal growth of tissue) of the skeleton. | 18 | 9.252638e-19 | 2 |
| HP | HP:0001909 | Leukemia | A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. | 20 | 7.792544e-18 | 2 |
| HP | HP:0009778 | Short thumb | Hypoplasia (congenital reduction in size) of the thumb. | 18 | 3.004914e-17 | 2 |
| HP | HP:0001882 | Decreased total leukocyte count | An abnormal decreased number of leukocytes in the blood. | 19 | 6.312546e-17 | 2 |
| HP | HP:0100834 | Neoplasm of the large intestine | The presence of a neoplasm of the large intestine. | 17 | 2.540192e-16 | 2 |
| HP | HP:0000519 | Developmental cataract | A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens. | 18 | 2.841809e-16 | 2 |
| HP | HP:0001875 | Decreased total neutrophil count | Abnormal decrease of absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group. | 20 | 4.219926e-16 | 2 |
| HP | HP:0009601 | Aplasia/Hypoplasia of the thumb | Hypoplastic/small or absent thumb. | 18 | 6.969233e-16 | 2 |
| HP | HP:0000294 | Low anterior hairline | Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella. | 18 | 7.892267e-16 | 2 |
| HP | HP:0000085 | Horseshoe kidney | A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline. | 18 | 8.929482e-16 | 2 |
| HP | HP:0000465 | Webbed neck | Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline. | 17 | 9.730943e-16 | 2 |
| HP | HP:0001680 | Coarctation of aorta | Coarctation of the aorta is a narrowing or constriction of a segment of the aorta. | 18 | 1.286473e-15 | 2 |
| HP | HP:0001789 | Hydrops fetalis | The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema. | 17 | 1.486897e-15 | 2 |
| HP | HP:0001421 | Abnormality of the musculature of the hand | Abnormality of the musculature of the hand | 17 | 1.708423e-15 | 2 |
| HP | HP:0001874 | Abnormality of neutrophils | A neutrophil abnormality. | 21 | 2.269730e-15 | 2 |
| HP | HP:0011991 | Abnormal total neutrophil count | A deviation from the normal range of neutrophil cell counts in the circulation. | 20 | 2.456205e-15 | 2 |
| HP | HP:0100242 | Sarcoma | A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant. | 18 | 6.417170e-15 | 2 |
| HP | HP:0008772 | Aplasia/Hypoplasia of the external ear | The presence of aplasia or developmental hypoplasia of all or part of the external ear. | 19 | 1.273296e-14 | 2 |
| HP | HP:0008771 | Aplasia/Hypoplasia of the ear | The presence of aplasia or developmental hypoplasia of the ear. | 19 | 2.392964e-14 | 2 |
| HP | HP:0410030 | Cleft lip | A gap in the lip or lips. | 19 | 4.038630e-14 | 2 |
| HP | HP:0000980 | Pallor | Abnormally pale skin. | 17 | 4.902354e-14 | 2 |
| HP | HP:0008551 | Microtia | Underdevelopment of the external ear. | 18 | 7.377338e-14 | 2 |
| HP | HP:0001911 | Abnormal granulocyte morphology | Any structural abnormality or abnormal count of granulocytes. | 21 | 7.670542e-14 | 2 |
| HP | HP:0032309 | Abnormal granulocyte count | Abnormal increase or decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group. | 20 | 7.812983e-14 | 2 |
| HP | HP:0100736 | Abnormal soft palate morphology | An abnormality of the soft palate. | 20 | 8.406454e-14 | 2 |
| HP | HP:0010972 | Anemia of inadequate production | A kind of anemia characterized by inadequate production of erythrocytes. | 18 | 1.693824e-13 | 2 |
| HP | HP:0100542 | Abnormal localization of kidney | An abnormal site of the kidney. | 19 | 2.081459e-13 | 2 |
| HP | HP:0004377 | Hematological neoplasm | Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). | 20 | 3.923973e-13 | 2 |
| HP | HP:0010974 | Abnormal myeloid leukocyte morphology | An abnormality of myeloid leukocytes. | 21 | 4.178927e-13 | 2 |
| HP | HP:0000599 | Abnormality of the frontal hairline | An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not. | 18 | 7.329596e-13 | 2 |
| HP | HP:0000782 | Abnormal scapula morphology | Any abnormality of the scapula, also known as the shoulder blade. | 17 | 7.829862e-13 | 2 |
| HP | HP:0001518 | Small for gestational age | Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age. | 19 | 1.639253e-12 | 2 |
| HP | HP:0009997 | Duplication of phalanx of hand | This term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated. | 18 | 1.916436e-12 | 2 |
| HP | HP:0004275 | Duplication of hand bones | Duplication of hand bones | 18 | 2.237457e-12 | 2 |
| HP | HP:0009142 | Duplication of bones involving the upper extremities | Duplication of bones involving the upper extremities | 18 | 2.237457e-12 | 2 |
| HP | HP:0009602 | Abnormality of thumb phalanx | A structural anomaly of one or more phalanges of the thumb. | 17 | 5.037251e-12 | 2 |
| HP | HP:0000104 | Renal agenesis | Agenesis, that is, failure of the kidney to develop during embryogenesis and development. | 17 | 7.607766e-12 | 2 |
| HP | HP:0034058 | Abnormal fetal morphology | Any structural anomaly of the fetus. | 19 | 2.426975e-11 | 2 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 17 | 4.786756e-11 | 2 |
| HP | HP:0001254 | Lethargy | A state of fatigue, either physical or mental slowness and sluggishness, with difficulties in initiating or performing simple tasks. Distinguished from apathy which implies indifference and a lack of desire or interest in the task. A person with lethargy may have the desire, but not the energy to engage in personal or socially relevant tasks. | 17 | 1.363756e-10 | 2 |
| HP | HP:0009553 | Abnormality of the hairline | The hairline refers to the outline of hair of the head. An abnormality of the hairline can refer to an unusually low or high border between areas of the scalp with and without hair or to abnormal projections of scalp hair. | 18 | 1.764460e-10 | 2 |
| HP | HP:0000286 | Epicanthus | A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus. | 23 | 4.656065e-10 | 2 |
| HP | HP:0010720 | Abnormal hair pattern | An abnormality of the distribution of hair growth. | 19 | 7.454278e-10 | 2 |
| HP | HP:0009381 | Short finger | Abnormally short finger associated with developmental hypoplasia. | 18 | 8.465357e-10 | 2 |
| HP | HP:0011361 | Congenital abnormal hair pattern | A congenital abnormality of the distribution of hair growth. | 18 | 9.414585e-10 | 2 |
| HP | HP:0007700 | Ocular anterior segment dysgenesis | Abnormal development (dysgenesis) of the anterior segment of the eye globe. These structures are mainly of mesenchymal origin. | 18 | 9.925737e-10 | 2 |
| HP | HP:0011893 | Abnormal leukocyte count | Number of leukocytes per volume of blood beyond normal limits. | 21 | 1.230356e-09 | 2 |
| HP | HP:0001446 | Abnormality of the musculature of the upper limbs | Abnormality of the musculature of the upper limbs | 17 | 1.456329e-09 | 2 |
| HP | HP:0001172 | Abnormal thumb morphology | An abnormal structure of the first digit of the hand. | 19 | 1.997310e-09 | 2 |
| HP | HP:0000470 | Short neck | Diminished length of the neck. | 19 | 2.504228e-09 | 2 |
| HP | HP:0007378 | Neoplasm of the gastrointestinal tract | A tumor (abnormal growth of tissue) of the gastrointestinal tract. | 17 | 3.026311e-09 | 2 |
| HP | HP:0011792 | Neoplasm by histology | Neoplasm categorized according to type of histological abnormality. | 18 | 4.074736e-09 | 2 |
| HP | HP:0000175 | Cleft palate | Cleft palate is a developmental defect of the palate resulting from a failure of fusion of the palatine processes and manifesting as a separation of the roof of the mouth (soft and hard palate). | 22 | 4.241706e-09 | 2 |
| HP | HP:0000369 | Low-set ears | Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear. | 24 | 4.442652e-09 | 2 |
| HP | HP:0034930 | Digestive system neoplasm | A tumor (abnormal growth of tissue) of the digestive system. | 18 | 4.935723e-09 | 2 |
| HP | HP:0006265 | Aplasia/Hypoplasia of fingers | Small/hypoplastic or absent/aplastic fingers. | 18 | 8.262510e-09 | 2 |
| HP | HP:0100037 | Abnormality of the scalp hair | An abnormality of the hair of head. | 19 | 1.034619e-08 | 2 |
| HP | HP:0000501 | Glaucoma | Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure. | 18 | 1.038489e-08 | 2 |
| HP | HP:0003319 | Abnormality of the cervical spine | Any abnormality of the cervical vertebral column. | 19 | 1.433244e-08 | 2 |
| HP | HP:0002250 | Abnormal large intestine morphology | Any abnormality of the large intestine. | 19 | 1.433244e-08 | 2 |
| HP | HP:0000202 | Orofacial cleft | The presence of a cleft (gap, opening, or groove) in the oral cavity, including cleft of the upper lip and/or cleft of the palate. Cleft of the upper lip is visible as a groove or fissure in the lip, most frequently due to a congenital failure of the maxillary and median nasal processes to fuse. Cleft palate is characterized by a grooved depression or fissure in the roof of the mouth, most often resulting from a congenital failure of the palate to fuse properly. Clefts of the lip and palate can occur individually or together. It is preferable to code each defect separately. | 22 | 1.648088e-08 | 2 |
| HP | HP:0000431 | Wide nasal bridge | Increased breadth of the nasal bridge (and with it, the nasal root). | 20 | 1.823035e-08 | 2 |
| HP | HP:5201015 | Craniofacial cleft | Congenital abnormality with cleft (gap or opening) in the craniofacial bones. Craniofacial cleft includes facial cleft, orofacial clef, and cleft of the jaw. | 22 | 1.924456e-08 | 2 |
| HP | HP:0001965 | Abnormal scalp morphology | Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows. | 19 | 2.052021e-08 | 2 |
| HP | HP:0011873 | Abnormal platelet count | Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood. | 19 | 2.496203e-08 | 2 |
| HP | HP:0100627 | Displacement of the urethral meatus | A displacement of the external urethral orifice from its normal position (in males normally placed at the tip of glans penis, in females normally placed about 2.5 cm behind the glans clitoridis and immediately in front of that of the vagina). | 18 | 2.732085e-08 | 2 |
| HP | HP:0011875 | Abnormal platelet morphology | An anomaly in platelet form, ultrastructure, or intracellular organelles. | 19 | 2.914821e-08 | 2 |
| HP | HP:0032076 | Abnormal male urethral meatus morphology | Abnormal male urethral meatus morphology | 18 | 2.974376e-08 | 2 |
| HP | HP:0001679 | Abnormal aortic morphology | An abnormality of the aorta. | 18 | 3.989770e-08 | 2 |
| HP | HP:0008678 | Renal hypoplasia/aplasia | Absence or underdevelopment of the kidney. | 17 | 5.912827e-08 | 2 |
| HP | HP:0001872 | Abnormality of thrombocytes | An abnormality of platelets. | 19 | 7.707021e-08 | 2 |
| HP | HP:0001873 | Thrombocytopenia | A reduction in the number of circulating thrombocytes. | 18 | 7.957391e-08 | 2 |
| HP | HP:0000218 | High palate | Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective). | 23 | 8.838048e-08 | 2 |
| HP | HP:0001903 | Anemia | A reduction in erythrocytes volume or hemoglobin concentration. | 21 | 9.944885e-08 | 2 |
| HP | HP:0010987 | Abnormal cellular immune system morphology | An abnormality of the morphology or counts of the cells that make up the immune system. | 21 | 1.056512e-07 | 2 |
| HP | HP:0001881 | Abnormal leukocyte morphology | An abnormality of leukocytes. | 21 | 1.056512e-07 | 2 |
| HP | HP:0000047 | Hypospadias | Abnormal position of urethral meatus on the ventral penile shaft (underside) characterized by displacement of the urethral meatus from the tip of the glans penis to the ventral surface of the penis, scrotum, or perineum. | 17 | 1.470871e-07 | 2 |
| HP | HP:0032251 | Abnormal immune system morphology | Abnormal immune system morphology | 21 | 2.342469e-07 | 2 |
| HP | HP:0000316 | Hypertelorism | Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes). | 23 | 2.665527e-07 | 2 |
| HP | HP:0000159 | Abnormal lip morphology | An abnormality of the lip. | 27 | 2.890094e-07 | 2 |
| HP | HP:0000347 | Micrognathia | Developmental hypoplasia of the mandible. | 23 | 3.413716e-07 | 2 |
| HP | HP:0009118 | Aplasia/Hypoplasia of the mandible | Absence or underdevelopment of the mandible. | 23 | 3.585425e-07 | 2 |
| HP | HP:0000795 | Abnormality of the urethra | An abnormality of the urethra, i.e., of the tube which connects the urinary bladder to the outside of the body. | 18 | 3.864189e-07 | 2 |
| HP | HP:0009116 | Aplasia/Hypoplasia involving bones of the skull | Aplasia/Hypoplasia involving bones of the skull | 23 | 4.464148e-07 | 2 |
| HP | HP:0011927 | Short digit | One or more digit that appears disproportionately short compared to the hand/foot, whereby either the entire digit or a specific phalanx is shortened. | 20 | 4.715154e-07 | 2 |
| HP | HP:0000357 | Abnormal location of ears | Abnormal location of the ear. | 24 | 5.013045e-07 | 2 |
| HP | HP:0001631 | Atrial septal defect | Atrial septal defect (ASD) is a congenital abnormality of the interatrial septum that enables blood flow between the left and right atria via the interatrial septum. | 19 | 5.033980e-07 | 2 |
| HP | HP:0001671 | Abnormal cardiac septum morphology | An anomaly of the intra-atrial or intraventricular septum. | 22 | 5.713574e-07 | 2 |
| HP | HP:0011994 | Abnormal atrial septum morphology | An abnormality of the interatrial septum. | 19 | 5.721173e-07 | 2 |
| HP | HP:0005280 | Depressed nasal bridge | Posterior positioning of the nasal root in relation to the overall facial profile for age. | 20 | 5.972360e-07 | 2 |
| HP | HP:0001877 | Abnormal erythrocyte morphology | Any structural abnormality of erythrocytes (red-blood cells). | 21 | 6.067055e-07 | 2 |
| HP | HP:0000032 | Abnormal male external genitalia morphology | Any structural abnormality of male external genitalia. | 25 | 1.368555e-06 | 2 |
| HP | HP:0034057 | Fetal anomaly | Structural or functional abnormalities of the fetus. Note that this section comprises terms that describe abnormalities that are specific to the fetus or differ from the corresponding general terms. A term from anywhere in the Human Phenotype Ontology can be applied to a fetus if appropriate. | 19 | 1.489319e-06 | 2 |
| HP | HP:0001629 | Ventricular septal defect | A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum. | 18 | 1.951389e-06 | 2 |
| HP | HP:0025668 | Abnormal neck morphology | Any structural anomaly of the neck region. | 20 | 2.238757e-06 | 2 |
| HP | HP:0010438 | Abnormal ventricular septum morphology | A structural abnormality of the interventricular septum. | 18 | 2.760317e-06 | 2 |
| HP | HP:0000811 | Abnormal external genitalia morphology | A structural anomaly of the external genitalia. | 25 | 3.335913e-06 | 2 |
| HP | HP:0000036 | Abnormal penis morphology | Abnormality of the male external sex organ. | 20 | 3.337160e-06 | 2 |
| HP | HP:0010461 | Abnormality of the male genitalia | Abnormality of the male genital system. | 25 | 3.673674e-06 | 2 |
| HP | HP:0005927 | Aplasia/hypoplasia involving bones of the hand | Absence (due to failure to form) or underdevelopment of the bones of the hand. | 18 | 4.114797e-06 | 2 |
| HP | HP:0005120 | Abnormal cardiac atrium morphology | Any structural abnormality of a cardiac atrium. | 19 | 4.452348e-06 | 2 |
| HP | HP:0009122 | Aplasia/hypoplasia affecting bones of the axial skeleton | Absence (due to failure to form) or underdevelopment of bones of the axial skeleton. | 23 | 4.505058e-06 | 2 |
| HP | HP:0000174 | Abnormal palate morphology | Any abnormality of the palate, i.e., of roof of the mouth. | 25 | 4.621185e-06 | 2 |
| HP | HP:0011004 | Abnormal systemic arterial morphology | An abnormality of the systemic arterial tree, which consists of the aorta and other systemic arteries. | 18 | 5.552249e-06 | 2 |
| HP | HP:0000464 | Abnormality of the neck | An abnormality of the neck. | 20 | 7.951123e-06 | 2 |
| HP | HP:0000377 | Abnormal pinna morphology | An abnormality of the pinna, which is also referred to as the auricle or external ear. | 26 | 8.387222e-06 | 2 |
| HP | HP:0000549 | Abnormal conjugate eye movement | Any deviation from the normal motor coordination of the eyes that allows for bilateral fixation on a single object. | 25 | 1.028125e-05 | 2 |
| HP | HP:0000356 | Abnormality of the outer ear | An abnormality of the external ear. | 26 | 1.070324e-05 | 2 |
| HP | HP:0006496 | Aplasia/hypoplasia involving bones of the upper limbs | Absence (due to failure to form) or underdevelopment of the bones of the upper limbs. | 18 | 1.143112e-05 | 2 |
| HP | HP:0009127 | Abnormality of the musculature of the limbs | Abnormality of the musculature of the limbs | 19 | 1.171362e-05 | 2 |
| HP | HP:0001595 | Abnormal hair morphology | An abnormality of the hair. | 26 | 1.698188e-05 | 2 |
| HP | HP:0000252 | Microcephaly | Head circumference below 2 standard deviations below the mean for age and gender. | 26 | 1.727100e-05 | 2 |
| HP | HP:0100886 | Abnormality of globe location | An abnormality in the placement of the ocular globe (eyeball). | 24 | 1.738642e-05 | 2 |
| HP | HP:0002242 | Abnormal intestine morphology | An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine. | 20 | 1.984893e-05 | 2 |
| HP | HP:0011793 | Neoplasm by anatomical site | Neoplasm categorized according to the anatomical site of origin of the neoplasm. | 22 | 2.110107e-05 | 2 |
| HP | HP:0040195 | Decreased head circumference | An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean. | 26 | 2.148002e-05 | 2 |
| HP | HP:0005918 | Abnormal finger phalanx morphology | Abnormalities affecting the phalanx of finger. | 19 | 2.442182e-05 | 2 |
| HP | HP:0012718 | Abnormal gastrointestinal tract morphology | Abnormal structure of the gastrointestinal tract. | 22 | 3.358981e-05 | 2 |
| HP | HP:0002664 | Neoplasm | An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor). | 22 | 3.495336e-05 | 2 |
| HP | HP:0000492 | Abnormal eyelid morphology | An abnormality of the eyelids. | 26 | 3.519546e-05 | 2 |
| HP | HP:0010936 | Abnormality of the lower urinary tract | An abnormality of the lower urinary tract. | 21 | 3.537705e-05 | 2 |
| HP | HP:0000486 | Strabismus | A misalignment of the eyes so that the visual axes deviate from bifoveal fixation. The classification of strabismus may be based on a number of features including the relative position of the eyes, whether the deviation is latent or manifest, intermittent or constant, concomitant or otherwise and according to the age of onset and the relevance of any associated refractive error. | 24 | 3.665471e-05 | 2 |
| HP | HP:0000002 | Abnormality of body height | Deviation from the norm of height with respect to that which is expected according to age and gender norms. | 27 | 3.788877e-05 | 2 |
| HP | HP:0002060 | Abnormal cerebral morphology | Any structural abnormality of the telencephalon, which is also known as the cerebrum. | 31 | 3.795866e-05 | 2 |
| HP | HP:0004322 | Short stature | A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to \"short stature\" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms). | 26 | 3.816640e-05 | 2 |
| HP | HP:0005922 | Abnormal hand morphology | Any structural anomaly of the hand. | 23 | 4.169567e-05 | 2 |
| HP | HP:0030791 | Abnormal jaw morphology | A structural anomaly of the jaw, the bony structure of the mouth that consists of the mandible and the maxilla. | 24 | 4.777578e-05 | 2 |
| HP | HP:0100547 | Abnormal forebrain morphology | An abnormality of the forebrain, which has as its parts the telencephalon, diencephalon, lateral ventricles and third ventricle. | 31 | 5.725263e-05 | 2 |
| HP | HP:0000925 | Abnormality of the vertebral column | Any abnormality of the vertebral column. | 27 | 7.080614e-05 | 2 |
| HP | HP:0000518 | Cataract | A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule. | 20 | 8.066717e-05 | 2 |
| HP | HP:0001167 | Abnormal finger morphology | An anomaly of a finger. | 24 | 1.032781e-04 | 2 |
| HP | HP:0000517 | Abnormal lens morphology | An abnormality of the lens. | 20 | 1.128256e-04 | 2 |
| HP | HP:0000277 | Abnormal mandible morphology | Any abnormality of the mandible, the bone of the lower jaw. | 23 | 1.164541e-04 | 2 |
| HP | HP:0000745 | Abnormal diminished volition | A reduction in willful and motivated goal-directed behavior that is considered the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action. | 18 | 1.195047e-04 | 2 |
| HP | HP:0007364 | Aplasia/Hypoplasia of the cerebrum | Aplasia/Hypoplasia of the cerebrum | 27 | 1.316039e-04 | 2 |
| HP | HP:0000422 | Abnormal nasal bridge morphology | Abnormality of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi. | 22 | 1.374357e-04 | 2 |
| HP | HP:0030669 | Abnormal ocular adnexa morphology | A structural anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. | 27 | 1.456404e-04 | 2 |
| HP | HP:0000508 | Ptosis | The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective). | 19 | 1.550132e-04 | 2 |
| HP | HP:0025033 | Abnormal digestive system morphology | A structural anomaly of the digestive system. | 22 | 1.588667e-04 | 2 |
| HP | HP:0000969 | Edema | An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body. | 18 | 1.657357e-04 | 2 |
| HP | HP:0045060 | Aplasia/hypoplasia involving bones of the extremities | Aplasia/hypoplasia involving bones of the extremities | 18 | 1.816981e-04 | 2 |
| HP | HP:0032039 | Abnormality of the ocular adnexa | An anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. | 27 | 1.995558e-04 | 2 |
| HP | HP:0005105 | Abnormal nasal morphology | Abnormal nasal morphology | 26 | 2.053237e-04 | 2 |
| HP | HP:0011138 | Abnormal skin adnexa morphology | An abnormality of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands. | 26 | 2.114596e-04 | 2 |
| HP | HP:0002977 | Aplasia/Hypoplasia involving the central nervous system | Absence or underdevelopment of tissue in the central nervous system. | 29 | 2.144606e-04 | 2 |
| HP | HP:0012243 | Abnormal reproductive system morphology | A structural or developmental anomaly of any of the tissues involved in the genital system. | 25 | 2.247304e-04 | 2 |
| HP | HP:0011821 | Abnormal facial skeleton morphology | An abnormality of one or more of the set of bones that make up the facial skeleton. | 25 | 2.281891e-04 | 2 |
| HP | HP:0000315 | Abnormality of the orbital region | Abnormality of the orbital region | 27 | 2.916078e-04 | 2 |
| HP | HP:0025780 | Abnormal volitional state | An abnormality of internal states of motivation or drive that compromise, or interfere with, the ability of the person to attend to basic personal, social, or vocational activities. | 23 | 3.317638e-04 | 2 |
| HP | HP:0031703 | Abnormal ear morphology | Any structural anomaly of the ear. | 27 | 3.637713e-04 | 2 |
| HP | HP:0001713 | Abnormal cardiac ventricle morphology | An abnormality of a cardiac ventricle. | 18 | 4.041022e-04 | 2 |
| HP | HP:0009815 | Aplasia/hypoplasia of the extremities | Absence (due to failure to form) or underdevelopment of the extremities. | 18 | 4.693941e-04 | 2 |
| HP | HP:0000290 | Abnormal forehead morphology | An anomaly of the forehead. | 23 | 4.808716e-04 | 2 |
| HP | HP:0034684 | Abnormal enzyme concentration or activity | Concentration or activity of an enzyme is above or below the limits of normal. | 18 | 5.218331e-04 | 2 |
| HP | HP:0012443 | Abnormal brain morphology | A structural abnormality of the brain, which has as its parts the forebrain, midbrain, and hindbrain. | 33 | 6.270961e-04 | 2 |
| HP | HP:0009115 | Aplasia/hypoplasia involving the skeleton | Absence (due to failure to form) or underdevelopment of one or more components of the skeleton. | 23 | 6.490995e-04 | 2 |
| HP | HP:0030962 | Abnormal morphology of the great vessels | A structural anomaly affecting a blood vessel involved in the circulation of the heart, i.e., the superior or inferior vena cava, the pulmonary arteries, the pulmonary veins, and the aorta. | 18 | 6.986986e-04 | 2 |
| HP | HP:0001155 | Abnormality of the hand | An abnormality affecting one or both hands. | 26 | 7.271253e-04 | 2 |
| HP | HP:0001197 | Abnormality of prenatal development or birth | An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities. | 21 | 8.457847e-04 | 2 |
| HP | HP:0011844 | Abnormal appendicular skeleton morphology | An abnormality of the appendicular skeletal system, consisting of the of the limbs, shoulder and pelvic girdles. | 28 | 8.759531e-04 | 2 |
| HP | HP:0002817 | Abnormality of the upper limb | An abnormality of the arm. | 27 | 9.650559e-04 | 2 |
| HP | HP:0002813 | Abnormal limb bone morphology | Any abnormality of bones of the arms or legs. | 27 | 1.029765e-03 | 2 |
| HP | HP:0040068 | Abnormality of limb bone | Abnormality of limb bone | 27 | 1.029765e-03 | 2 |
| HP | HP:0000366 | Abnormality of the nose | An abnormality of the nose. | 27 | 1.084455e-03 | 2 |
| HP | HP:0011032 | Abnormality of fluid regulation | An abnormality of the regulation of body fluids. | 18 | 1.134762e-03 | 2 |
| HP | HP:0000240 | Abnormality of skull size | Any abnormality of the size of the skull. | 26 | 1.182270e-03 | 2 |
| HP | HP:0011297 | Abnormal digit morphology | A morphological abnormality of a digit, i.e., of a finger or toe. | 25 | 1.635759e-03 | 2 |
| HP | HP:0000496 | Abnormality of eye movement | An abnormality in voluntary or involuntary eye movements or their control. | 27 | 2.650382e-03 | 2 |
| HP | HP:0000078 | Abnormality of the genital system | An abnormality of the genital system. | 26 | 2.889651e-03 | 2 |
| HP | HP:0025766 | Abnormal affect | An anomaly in intensity, frequency, or duration of the verbal or behavioral expression of emotions, feelings, or thoughts. | 23 | 3.124029e-03 | 2 |
| HP | HP:0000765 | Abnormal thorax morphology | Any abnormality of the thorax (the region of the body formed by the sternum, the thoracic vertebrae and the ribs). | 19 | 3.639038e-03 | 2 |
| HP | HP:0001871 | Abnormality of blood and blood-forming tissues | An abnormality of the hematopoietic system. | 24 | 5.603523e-03 | 2 |
| HP | HP:0001510 | Growth delay | A deficiency or slowing down of growth pre- and postnatally. | 27 | 6.050180e-03 | 2 |
| HP | HP:0002011 | Morphological central nervous system abnormality | A structural abnormality of the central nervous system. | 33 | 6.367962e-03 | 2 |
| HP | HP:0011024 | Abnormality of the gastrointestinal tract | An abnormality of the gastrointestinal tract. | 26 | 6.501622e-03 | 2 |
| HP | HP:0001627 | Abnormal heart morphology | Any structural anomaly of the heart. | 24 | 1.082936e-02 | 2 |
| HP | HP:0004328 | Abnormal anterior eye segment morphology | An abnormality of the anterior segment of the eyeball (which comprises the structures in front of the vitreous humor: the cornea, iris, ciliary body, and lens). | 22 | 1.193404e-02 | 2 |
| HP | HP:0030680 | Abnormal cardiovascular system morphology | Any structural anomaly of the heart and blood vessels. | 27 | 1.357079e-02 | 2 |
| HP | HP:0012639 | Abnormal nervous system morphology | A structural anomaly of the nervous system. | 33 | 1.436090e-02 | 2 |
| HP | HP:0000006 | Autosomal dominant inheritance | A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele. | 27 | 1.466385e-02 | 2 |
| HP | HP:0011121 | Abnormal skin morphology | Any morphological abnormality of the skin. | 27 | 1.710165e-02 | 2 |
| HP | HP:0025015 | Abnormal vascular morphology | Abnormal vascular morphology | 20 | 2.794248e-02 | 2 |
| HP | HP:0033353 | Abnormal blood vessel morphology | Any structural anomaly of a blood vessel (artery, arteriole, capillary, venule, or vein). | 18 | 4.815055e-02 | 2 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 62 | 1.891746e-20 | 2 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 80 | 6.572827e-19 | 2 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 84 | 1.335718e-18 | 2 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 54 | 2.489673e-17 | 2 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 95 | 6.859152e-16 | 2 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 79 | 1.353666e-15 | 2 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 54 | 4.490692e-15 | 2 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 79 | 4.539749e-15 | 2 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 81 | 5.057139e-15 | 2 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 86 | 1.499455e-14 | 2 |
| HPA | HPA:0620000 | Vagina | Vagina | 92 | 4.066774e-14 | 2 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 92 | 4.066774e-14 | 2 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 84 | 4.712024e-14 | 2 |
| HPA | HPA:0090163 | Cerebellum; Purkinje cells[High] | Cerebellum; Purkinje cells[High] | 48 | 9.569408e-14 | 2 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 84 | 2.572004e-13 | 2 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 41 | 3.925572e-13 | 2 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 86 | 5.280380e-13 | 2 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 78 | 8.501601e-13 | 2 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 92 | 1.288527e-12 | 2 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 92 | 1.288527e-12 | 2 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 42 | 1.407958e-12 | 2 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 95 | 2.480542e-12 | 2 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 75 | 3.529241e-12 | 2 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 82 | 4.857697e-12 | 2 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 93 | 5.133138e-12 | 2 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 94 | 5.528197e-12 | 2 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 95 | 6.228975e-12 | 2 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 95 | 6.228975e-12 | 2 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 97 | 6.331990e-12 | 2 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 97 | 6.331990e-12 | 2 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 83 | 7.833406e-12 | 2 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 61 | 1.071459e-11 | 2 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 74 | 1.277192e-11 | 2 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 96 | 2.243959e-11 | 2 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 94 | 2.424749e-11 | 2 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 94 | 2.424749e-11 | 2 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 85 | 2.482306e-11 | 2 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 95 | 4.342115e-11 | 2 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 97 | 5.124501e-11 | 2 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 88 | 7.241811e-11 | 2 |
| HPA | HPA:0400000 | Rectum | Rectum | 99 | 7.563179e-11 | 2 |
| HPA | HPA:0630000 | Cervix | Cervix | 94 | 8.058818e-11 | 2 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 41 | 8.823210e-11 | 2 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 94 | 1.004640e-10 | 2 |
| HPA | HPA:0080000 | Caudate | Caudate | 94 | 1.330050e-10 | 2 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 82 | 2.299603e-10 | 2 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 92 | 2.482869e-10 | 2 |
| HPA | HPA:0390000 | Prostate | Prostate | 92 | 2.482869e-10 | 2 |
| HPA | HPA:0380521 | Placenta; trophoblastic cells[≥Low] | Placenta; trophoblastic cells[≥Low] | 90 | 2.587465e-10 | 2 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 42 | 3.196904e-10 | 2 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 77 | 4.488430e-10 | 2 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 72 | 4.563403e-10 | 2 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 75 | 5.084081e-10 | 2 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 82 | 5.234985e-10 | 2 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 38 | 5.671214e-10 | 2 |
| HPA | HPA:0090161 | Cerebellum; Purkinje cells[≥Low] | Cerebellum; Purkinje cells[≥Low] | 84 | 6.071546e-10 | 2 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 98 | 6.268798e-10 | 2 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 89 | 6.383264e-10 | 2 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 87 | 6.487094e-10 | 2 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 88 | 9.001861e-10 | 2 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 82 | 1.248814e-09 | 2 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 92 | 1.384414e-09 | 2 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 78 | 1.482352e-09 | 2 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 97 | 2.357066e-09 | 2 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 79 | 2.369627e-09 | 2 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 93 | 2.380589e-09 | 2 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 65 | 2.565025e-09 | 2 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 79 | 2.648158e-09 | 2 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 95 | 2.797160e-09 | 2 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 91 | 3.056185e-09 | 2 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 92 | 4.381069e-09 | 2 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 84 | 4.725393e-09 | 2 |
| HPA | HPA:0290401 | Liver; hepatocytes[≥Low] | Liver; hepatocytes[≥Low] | 84 | 4.953662e-09 | 2 |
| HPA | HPA:0130000 | Colon | Colon | 99 | 5.824360e-09 | 2 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 69 | 5.884579e-09 | 2 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 97 | 6.526530e-09 | 2 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 35 | 7.271996e-09 | 2 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 88 | 8.081112e-09 | 2 |
| HPA | HPA:0380000 | Placenta | Placenta | 95 | 9.775187e-09 | 2 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 90 | 1.090983e-08 | 2 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 90 | 1.090983e-08 | 2 |
| HPA | HPA:0050000 | Breast | Breast | 93 | 1.327381e-08 | 2 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 55 | 1.984124e-08 | 2 |
| HPA | HPA:0290000 | Liver | Liver | 87 | 2.242298e-08 | 2 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 94 | 2.394291e-08 | 2 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 64 | 2.538762e-08 | 2 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 94 | 2.589013e-08 | 2 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 95 | 2.756639e-08 | 2 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 95 | 2.756639e-08 | 2 |
| HPA | HPA:0530000 | Spleen | Spleen | 84 | 2.900472e-08 | 2 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 49 | 2.970935e-08 | 2 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 78 | 3.660396e-08 | 2 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 39 | 3.749023e-08 | 2 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 85 | 3.940048e-08 | 2 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 88 | 4.288287e-08 | 2 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 88 | 4.288287e-08 | 2 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 89 | 4.353825e-08 | 2 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 90 | 4.829065e-08 | 2 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 95 | 4.860672e-08 | 2 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 95 | 4.860672e-08 | 2 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 82 | 5.271061e-08 | 2 |
| HPA | HPA:0570731 | Testis; Leydig cells[≥Low] | Testis; Leydig cells[≥Low] | 92 | 5.753635e-08 | 2 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 93 | 7.187071e-08 | 2 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 93 | 7.187071e-08 | 2 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 54 | 7.995651e-08 | 2 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 38 | 9.508026e-08 | 2 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 60 | 1.053750e-07 | 2 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 30 | 1.314169e-07 | 2 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 92 | 1.597960e-07 | 2 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 69 | 1.790518e-07 | 2 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 74 | 2.277783e-07 | 2 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 42 | 2.462322e-07 | 2 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 91 | 2.584602e-07 | 2 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 91 | 2.584602e-07 | 2 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 31 | 2.803007e-07 | 2 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 64 | 2.843104e-07 | 2 |
| HPA | HPA:0030000 | Appendix | Appendix | 95 | 3.233216e-07 | 2 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 80 | 4.253390e-07 | 2 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 68 | 4.715198e-07 | 2 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 35 | 5.672596e-07 | 2 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 49 | 6.075950e-07 | 2 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 80 | 6.316501e-07 | 2 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 96 | 7.595317e-07 | 2 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 88 | 8.690440e-07 | 2 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 67 | 1.101675e-06 | 2 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 31 | 1.375433e-06 | 2 |
| HPA | HPA:0470682 | Skin 2; epidermal cells[≥Medium] | Skin 2; epidermal cells[≥Medium] | 65 | 1.380613e-06 | 2 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 83 | 1.383541e-06 | 2 |
| HPA | HPA:0470683 | Skin 2; epidermal cells[High] | Skin 2; epidermal cells[High] | 30 | 1.695231e-06 | 2 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 93 | 2.239040e-06 | 2 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 93 | 2.239040e-06 | 2 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 90 | 2.883598e-06 | 2 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 48 | 2.954231e-06 | 2 |
| HPA | HPA:0340000 | Ovary | Ovary | 77 | 2.959710e-06 | 2 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 79 | 3.257750e-06 | 2 |
| HPA | HPA:0300000 | Lung | Lung | 91 | 3.331143e-06 | 2 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 24 | 3.489346e-06 | 2 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 38 | 3.782839e-06 | 2 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 24 | 3.997869e-06 | 2 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 71 | 6.522851e-06 | 2 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 35 | 7.550175e-06 | 2 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 42 | 1.036399e-05 | 2 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 85 | 1.176219e-05 | 2 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 24 | 1.257826e-05 | 2 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 60 | 1.417262e-05 | 2 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 23 | 1.725911e-05 | 2 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 63 | 1.836879e-05 | 2 |
| HPA | HPA:0030052 | Appendix; glandular cells[≥Medium] | Appendix; glandular cells[≥Medium] | 76 | 1.923471e-05 | 2 |
| HPA | HPA:0270000 | Kidney | Kidney | 95 | 1.978127e-05 | 2 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 80 | 2.238005e-05 | 2 |
| HPA | HPA:0320101 | Nasopharynx; respiratory epithelial cells[≥Low] | Nasopharynx; respiratory epithelial cells[≥Low] | 78 | 2.315334e-05 | 2 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 79 | 2.362157e-05 | 2 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 79 | 2.362157e-05 | 2 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 24 | 2.555231e-05 | 2 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 26 | 2.816045e-05 | 2 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 90 | 2.850185e-05 | 2 |
| HPA | HPA:0460662 | Skin 1; keratinocytes[≥Medium] | Skin 1; keratinocytes[≥Medium] | 55 | 3.158529e-05 | 2 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 69 | 3.409041e-05 | 2 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 70 | 4.835556e-05 | 2 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 76 | 4.859941e-05 | 2 |
| HPA | HPA:0400052 | Rectum; glandular cells[≥Medium] | Rectum; glandular cells[≥Medium] | 80 | 5.217995e-05 | 2 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 70 | 5.696932e-05 | 2 |
| HPA | HPA:0380523 | Placenta; trophoblastic cells[High] | Placenta; trophoblastic cells[High] | 39 | 7.947416e-05 | 2 |
| HPA | HPA:0060101 | Bronchus; respiratory epithelial cells[≥Low] | Bronchus; respiratory epithelial cells[≥Low] | 78 | 8.910843e-05 | 2 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 21 | 9.487956e-05 | 2 |
| HPA | HPA:0130201 | Colon; endothelial cells[≥Low] | Colon; endothelial cells[≥Low] | 76 | 9.927171e-05 | 2 |
| HPA | HPA:0480052 | Small intestine; glandular cells[≥Medium] | Small intestine; glandular cells[≥Medium] | 79 | 1.188222e-04 | 2 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 19 | 1.283702e-04 | 2 |
| HPA | HPA:0400652 | Rectum; fibroblasts[≥Medium] | Rectum; fibroblasts[≥Medium] | 9 | 1.381534e-04 | 2 |
| HPA | HPA:0570000 | Testis | Testis | 98 | 1.405158e-04 | 2 |
| HPA | HPA:0270361 | Kidney; cells in tubules[≥Low] | Kidney; cells in tubules[≥Low] | 86 | 1.408605e-04 | 2 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 73 | 1.539205e-04 | 2 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 60 | 1.651184e-04 | 2 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 60 | 1.651184e-04 | 2 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 22 | 1.658834e-04 | 2 |
| HPA | HPA:0060103 | Bronchus; respiratory epithelial cells[High] | Bronchus; respiratory epithelial cells[High] | 37 | 1.785095e-04 | 2 |
| HPA | HPA:0290402 | Liver; hepatocytes[≥Medium] | Liver; hepatocytes[≥Medium] | 58 | 1.840238e-04 | 2 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 19 | 2.026468e-04 | 2 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 19 | 2.192477e-04 | 2 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 36 | 2.958029e-04 | 2 |
| HPA | HPA:0400242 | Rectum; peripheral nerve/ganglion[≥Medium] | Rectum; peripheral nerve/ganglion[≥Medium] | 11 | 3.179607e-04 | 2 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 72 | 3.509366e-04 | 2 |
| HPA | HPA:0400651 | Rectum; fibroblasts[≥Low] | Rectum; fibroblasts[≥Low] | 9 | 3.879426e-04 | 2 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 25 | 4.117793e-04 | 2 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 39 | 4.474404e-04 | 2 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 46 | 4.559168e-04 | 2 |
| HPA | HPA:0130052 | Colon; glandular cells[≥Medium] | Colon; glandular cells[≥Medium] | 77 | 5.134082e-04 | 2 |
| HPA | HPA:0460641 | Skin 1; Langerhans[≥Low] | Skin 1; Langerhans[≥Low] | 59 | 5.156767e-04 | 2 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 68 | 5.173377e-04 | 2 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 22 | 5.581327e-04 | 2 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 38 | 5.969895e-04 | 2 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 23 | 5.989675e-04 | 2 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 20 | 6.563025e-04 | 2 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 59 | 7.021811e-04 | 2 |
| HPA | HPA:0460642 | Skin 1; Langerhans[≥Medium] | Skin 1; Langerhans[≥Medium] | 45 | 7.217827e-04 | 2 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 23 | 7.274795e-04 | 2 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 23 | 7.856147e-04 | 2 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 60 | 9.514019e-04 | 2 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 19 | 9.530745e-04 | 2 |
| HPA | HPA:0030053 | Appendix; glandular cells[High] | Appendix; glandular cells[High] | 36 | 1.018264e-03 | 2 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 10 | 1.128734e-03 | 2 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 19 | 1.169282e-03 | 2 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 22 | 1.214858e-03 | 2 |
| HPA | HPA:0030892 | Appendix; goblet cells[≥Medium] | Appendix; goblet cells[≥Medium] | 13 | 1.255791e-03 | 2 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 18 | 1.337214e-03 | 2 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 13 | 1.345780e-03 | 2 |
| HPA | HPA:0150052 | Duodenum; glandular cells[≥Medium] | Duodenum; glandular cells[≥Medium] | 77 | 1.403547e-03 | 2 |
| HPA | HPA:0031292 | Appendix; endocrine cells[≥Medium] | Appendix; endocrine cells[≥Medium] | 14 | 1.405403e-03 | 2 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 20 | 1.589621e-03 | 2 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 48 | 1.650995e-03 | 2 |
| HPA | HPA:0400243 | Rectum; peripheral nerve/ganglion[High] | Rectum; peripheral nerve/ganglion[High] | 8 | 2.067993e-03 | 2 |
| HPA | HPA:0400051 | Rectum; glandular cells[≥Low] | Rectum; glandular cells[≥Low] | 84 | 2.141177e-03 | 2 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 17 | 2.772782e-03 | 2 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 59 | 2.830628e-03 | 2 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 22 | 2.905733e-03 | 2 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 20 | 2.966970e-03 | 2 |
| HPA | HPA:0150051 | Duodenum; glandular cells[≥Low] | Duodenum; glandular cells[≥Low] | 84 | 3.026351e-03 | 2 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 14 | 3.061235e-03 | 2 |
| HPA | HPA:0241101 | Heart muscle; cardiomyocytes[≥Low] | Heart muscle; cardiomyocytes[≥Low] | 78 | 3.084645e-03 | 2 |
| HPA | HPA:0240000 | Heart muscle | Heart muscle | 78 | 3.084645e-03 | 2 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 23 | 3.151617e-03 | 2 |
| HPA | HPA:0400892 | Rectum; goblet cells[≥Medium] | Rectum; goblet cells[≥Medium] | 13 | 3.257249e-03 | 2 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 45 | 3.303939e-03 | 2 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 19 | 3.546126e-03 | 2 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 15 | 3.554043e-03 | 2 |
| HPA | HPA:0130051 | Colon; glandular cells[≥Low] | Colon; glandular cells[≥Low] | 83 | 3.663107e-03 | 2 |
| HPA | HPA:0131292 | Colon; endocrine cells[≥Medium] | Colon; endocrine cells[≥Medium] | 14 | 3.733090e-03 | 2 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 18 | 3.905212e-03 | 2 |
| HPA | HPA:0401292 | Rectum; endocrine cells[≥Medium] | Rectum; endocrine cells[≥Medium] | 14 | 4.058889e-03 | 2 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 10 | 4.482141e-03 | 2 |
| HPA | HPA:0500111 | Soft tissue 1; chondrocytes[≥Low] | Soft tissue 1; chondrocytes[≥Low] | 38 | 4.975780e-03 | 2 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 68 | 5.273396e-03 | 2 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 19 | 5.375823e-03 | 2 |
| HPA | HPA:0130202 | Colon; endothelial cells[≥Medium] | Colon; endothelial cells[≥Medium] | 54 | 5.764604e-03 | 2 |
| HPA | HPA:0031302 | Appendix; enterocytes[≥Medium] | Appendix; enterocytes[≥Medium] | 13 | 5.765131e-03 | 2 |
| HPA | HPA:0400241 | Rectum; peripheral nerve/ganglion[≥Low] | Rectum; peripheral nerve/ganglion[≥Low] | 11 | 5.795142e-03 | 2 |
| HPA | HPA:0031291 | Appendix; endocrine cells[≥Low] | Appendix; endocrine cells[≥Low] | 14 | 6.095234e-03 | 2 |
| HPA | HPA:0131332 | Colon; mucosal lymphoid cells[≥Medium] | Colon; mucosal lymphoid cells[≥Medium] | 13 | 6.469885e-03 | 2 |
| HPA | HPA:0480051 | Small intestine; glandular cells[≥Low] | Small intestine; glandular cells[≥Low] | 83 | 6.940591e-03 | 2 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 10 | 7.005803e-03 | 2 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 39 | 7.731947e-03 | 2 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 12 | 7.990922e-03 | 2 |
| HPA | HPA:0600443 | Tonsil; non-germinal center cells[High] | Tonsil; non-germinal center cells[High] | 27 | 8.681282e-03 | 2 |
| HPA | HPA:0150053 | Duodenum; glandular cells[High] | Duodenum; glandular cells[High] | 42 | 9.046839e-03 | 2 |
| HPA | HPA:0030893 | Appendix; goblet cells[High] | Appendix; goblet cells[High] | 9 | 9.194095e-03 | 2 |
| HPA | HPA:0131302 | Colon; enterocytes[≥Medium] | Colon; enterocytes[≥Medium] | 13 | 9.567497e-03 | 2 |
| HPA | HPA:0030443 | Appendix; non-germinal center cells[High] | Appendix; non-germinal center cells[High] | 7 | 1.081629e-02 | 2 |
| HPA | HPA:0030891 | Appendix; goblet cells[≥Low] | Appendix; goblet cells[≥Low] | 13 | 1.095276e-02 | 2 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 13 | 1.155411e-02 | 2 |
| HPA | HPA:0131291 | Colon; endocrine cells[≥Low] | Colon; endocrine cells[≥Low] | 14 | 1.181049e-02 | 2 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 12 | 1.249127e-02 | 2 |
| HPA | HPA:0150892 | Duodenum; goblet cells[≥Medium] | Duodenum; goblet cells[≥Medium] | 12 | 1.249127e-02 | 2 |
| HPA | HPA:0151292 | Duodenum; endocrine cells[≥Medium] | Duodenum; endocrine cells[≥Medium] | 14 | 1.270528e-02 | 2 |
| HPA | HPA:0480053 | Small intestine; glandular cells[High] | Small intestine; glandular cells[High] | 41 | 1.274569e-02 | 2 |
| HPA | HPA:0130892 | Colon; goblet cells[≥Medium] | Colon; goblet cells[≥Medium] | 12 | 1.285715e-02 | 2 |
| HPA | HPA:0401291 | Rectum; endocrine cells[≥Low] | Rectum; endocrine cells[≥Low] | 14 | 1.333435e-02 | 2 |
| HPA | HPA:0031303 | Appendix; enterocytes[High] | Appendix; enterocytes[High] | 9 | 1.346635e-02 | 2 |
| HPA | HPA:0480892 | Small intestine; goblet cells[≥Medium] | Small intestine; goblet cells[≥Medium] | 12 | 1.482941e-02 | 2 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 13 | 1.580497e-02 | 2 |
| HPA | HPA:0400053 | Rectum; glandular cells[High] | Rectum; glandular cells[High] | 41 | 1.645743e-02 | 2 |
| HPA | HPA:0481292 | Small intestine; endocrine cells[≥Medium] | Small intestine; endocrine cells[≥Medium] | 14 | 1.651564e-02 | 2 |
| HPA | HPA:0460663 | Skin 1; keratinocytes[High] | Skin 1; keratinocytes[High] | 17 | 1.704072e-02 | 2 |
| HPA | HPA:0150891 | Duodenum; goblet cells[≥Low] | Duodenum; goblet cells[≥Low] | 13 | 1.794351e-02 | 2 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 16 | 2.021519e-02 | 2 |
| HPA | HPA:0400891 | Rectum; goblet cells[≥Low] | Rectum; goblet cells[≥Low] | 13 | 2.083851e-02 | 2 |
| HPA | HPA:0480891 | Small intestine; goblet cells[≥Low] | Small intestine; goblet cells[≥Low] | 13 | 2.083851e-02 | 2 |
| HPA | HPA:0130891 | Colon; goblet cells[≥Low] | Colon; goblet cells[≥Low] | 13 | 2.188973e-02 | 2 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 22 | 2.467150e-02 | 2 |
| HPA | HPA:0301171 | Lung; alveolar cells[≥Low] | Lung; alveolar cells[≥Low] | 50 | 2.485690e-02 | 2 |
| HPA | HPA:0400201 | Rectum; endothelial cells[≥Low] | Rectum; endothelial cells[≥Low] | 10 | 2.541715e-02 | 2 |
| HPA | HPA:0500653 | Soft tissue 1; fibroblasts[High] | Soft tissue 1; fibroblasts[High] | 15 | 2.553756e-02 | 2 |
| HPA | HPA:0030051 | Appendix; glandular cells[≥Low] | Appendix; glandular cells[≥Low] | 79 | 2.824924e-02 | 2 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 13 | 3.135130e-02 | 2 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 10 | 3.282286e-02 | 2 |
| HPA | HPA:0460652 | Skin 1; fibroblasts[≥Medium] | Skin 1; fibroblasts[≥Medium] | 43 | 3.295575e-02 | 2 |
| HPA | HPA:0080123 | Caudate; glial cells[High] | Caudate; glial cells[High] | 17 | 3.305957e-02 | 2 |
| HPA | HPA:0151291 | Duodenum; endocrine cells[≥Low] | Duodenum; endocrine cells[≥Low] | 14 | 3.456578e-02 | 2 |
| HPA | HPA:0481291 | Small intestine; endocrine cells[≥Low] | Small intestine; endocrine cells[≥Low] | 14 | 3.531063e-02 | 2 |
| HPA | HPA:0131303 | Colon; enterocytes[High] | Colon; enterocytes[High] | 9 | 3.884207e-02 | 2 |
| HPA | HPA:0270362 | Kidney; cells in tubules[≥Medium] | Kidney; cells in tubules[≥Medium] | 71 | 3.913724e-02 | 2 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 24 | 3.976570e-02 | 2 |
| HPA | HPA:0050093 | Breast; myoepithelial cells[High] | Breast; myoepithelial cells[High] | 19 | 4.112556e-02 | 2 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 24 | 4.131856e-02 | 2 |
| HPA | HPA:0471493 | Skin 2; vascular mural cells[High] | Skin 2; vascular mural cells[High] | 7 | 4.230176e-02 | 2 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 13 | 4.318887e-02 | 2 |
| HPA | HPA:0030433 | Appendix; germinal center cells[High] | Appendix; germinal center cells[High] | 6 | 4.368045e-02 | 2 |
| HPA | HPA:0460661 | Skin 1; keratinocytes[≥Low] | Skin 1; keratinocytes[≥Low] | 65 | 4.469394e-02 | 2 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 65 | 4.927217e-02 | 2 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 38 | 1.107452e-11 | 2 |
| MIRNA | MIRNA:hsa-mir-100-5p | hsa-mir-100-5p | hsa-mir-100-5p | 18 | 7.714267e-11 | 2 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 39 | 1.217384e-10 | 2 |
| MIRNA | MIRNA:hsa-mir-652-3p | hsa-mir-652-3p | hsa-mir-652-3p | 12 | 8.476537e-08 | 2 |
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 24 | 2.545980e-05 | 2 |
| MIRNA | MIRNA:hsa-mir-186-5p | hsa-mir-186-5p | hsa-mir-186-5p | 19 | 4.698945e-04 | 2 |
| MIRNA | MIRNA:hsa-mir-1296-5p | hsa-mir-1296-5p | hsa-mir-1296-5p | 8 | 1.171407e-03 | 2 |
| MIRNA | MIRNA:hsa-mir-92b-3p | hsa-mir-92b-3p | hsa-mir-92b-3p | 17 | 1.522481e-03 | 2 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 19 | 3.081052e-03 | 2 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M02065_1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | 79 | 5.429587e-08 | 2 |
| TF | TF:M02070 | Factor: TEL1; motif: CNCGGAANNN | Factor: TEL1; motif: CNCGGAANNN | 100 | 1.891655e-07 | 2 |
| TF | TF:M11392_1 | Factor: Erg; motif: NACCGGAARYN; match class: 1 | Factor: Erg; motif: NACCGGAARYN; match class: 1 | 49 | 4.874964e-07 | 2 |
| TF | TF:M00025 | Factor: Elk-1; motif: NNNNCCGGAARTNN | Factor: Elk-1; motif: NNNNCCGGAARTNN | 94 | 1.845940e-06 | 2 |
| TF | TF:M02070_1 | Factor: TEL1; motif: CNCGGAANNN; match class: 1 | Factor: TEL1; motif: CNCGGAANNN; match class: 1 | 61 | 2.081120e-06 | 2 |
| TF | TF:M08913 | Factor: FLI-1; motif: NAYTTCCGGT | Factor: FLI-1; motif: NAYTTCCGGT | 84 | 2.501889e-06 | 2 |
| TF | TF:M04691_1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | 96 | 3.802672e-06 | 2 |
| TF | TF:M11400 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 93 | 3.804079e-06 | 2 |
| TF | TF:M00025_1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | 57 | 4.253214e-06 | 2 |
| TF | TF:M02052 | Factor: EHF; motif: CSCGGAARTN | Factor: EHF; motif: CSCGGAARTN | 93 | 8.341796e-06 | 2 |
| TF | TF:M11392 | Factor: Erg; motif: NACCGGAARYN | Factor: Erg; motif: NACCGGAARYN | 85 | 9.538271e-06 | 2 |
| TF | TF:M11447 | Factor: Elf-1; motif: NAMCCGGAAGTN | Factor: Elf-1; motif: NAMCCGGAAGTN | 79 | 1.130710e-05 | 2 |
| TF | TF:M07140 | Factor: Kaiso; motif: NTCTCGCGAGANYTN | Factor: Kaiso; motif: NTCTCGCGAGANYTN | 18 | 1.607358e-05 | 2 |
| TF | TF:M11400_1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | 54 | 1.707549e-05 | 2 |
| TF | TF:M11428 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 75 | 1.753798e-05 | 2 |
| TF | TF:M11018_1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | 118 | 1.872525e-05 | 2 |
| TF | TF:M11452 | Factor: Elf-1; motif: NANGCGGAAGTR | Factor: Elf-1; motif: NANGCGGAAGTR | 69 | 2.002762e-05 | 2 |
| TF | TF:M04714 | Factor: Elf-1; motif: ACTTCCGGG | Factor: Elf-1; motif: ACTTCCGGG | 79 | 2.076907e-05 | 2 |
| TF | TF:M11451 | Factor: Elf-1; motif: NANCCGGAAGTN | Factor: Elf-1; motif: NANCCGGAAGTN | 73 | 2.474738e-05 | 2 |
| TF | TF:M12600 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | 84 | 2.571969e-05 | 2 |
| TF | TF:M03975_1 | Factor: ERG; motif: ACCGGAARTN; match class: 1 | Factor: ERG; motif: ACCGGAARTN; match class: 1 | 52 | 2.952919e-05 | 2 |
| TF | TF:M02062 | Factor: Erg; motif: ACCGGAAGTN | Factor: Erg; motif: ACCGGAAGTN | 80 | 3.366453e-05 | 2 |
| TF | TF:M03977_1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | 57 | 3.710798e-05 | 2 |
| TF | TF:M11396_1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | 59 | 3.742422e-05 | 2 |
| TF | TF:M11448 | Factor: Elf-1; motif: NANGCGGAAGTN | Factor: Elf-1; motif: NANGCGGAAGTN | 77 | 4.455436e-05 | 2 |
| TF | TF:M01660 | Factor: GABP-alpha; motif: CTTCCK | Factor: GABP-alpha; motif: CTTCCK | 97 | 4.684234e-05 | 2 |
| TF | TF:M08223_1 | Factor: Elk-1:OC-2; motif: RCCGGAASCGATCGATNN; match class: 1 | Factor: Elk-1:OC-2; motif: RCCGGAASCGATCGATNN; match class: 1 | 65 | 5.536397e-05 | 2 |
| TF | TF:M11435 | Factor: Elk-1; motif: NNCCGGAAGTN | Factor: Elk-1; motif: NNCCGGAAGTN | 100 | 5.696391e-05 | 2 |
| TF | TF:M09905 | Factor: SAP-1; motif: NNCCGGAAGTGN | Factor: SAP-1; motif: NNCCGGAAGTGN | 81 | 5.900340e-05 | 2 |
| TF | TF:M02065 | Factor: ER81; motif: RCCGGAARYN | Factor: ER81; motif: RCCGGAARYN | 105 | 6.821918e-05 | 2 |
| TF | TF:M03966 | Factor: ELF1; motif: AACCCGGAAGTR | Factor: ELF1; motif: AACCCGGAAGTR | 70 | 7.298670e-05 | 2 |
| TF | TF:M01214 | Factor: ESE-1; motif: NSMGGAARTN | Factor: ESE-1; motif: NSMGGAARTN | 76 | 8.014729e-05 | 2 |
| TF | TF:M02055 | Factor: ESE-1; motif: NSMGGAARTN | Factor: ESE-1; motif: NSMGGAARTN | 76 | 8.014729e-05 | 2 |
| TF | TF:M11382_1 | Factor: ESE-1; motif: NWTRCGGAWGCN; match class: 1 | Factor: ESE-1; motif: NWTRCGGAWGCN; match class: 1 | 52 | 9.189430e-05 | 2 |
| TF | TF:M04696_1 | Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN; match class: 1 | Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN; match class: 1 | 33 | 9.301663e-05 | 2 |
| TF | TF:M08759_1 | Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 | Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 | 42 | 1.017626e-04 | 2 |
| TF | TF:M08913_1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | 43 | 1.042908e-04 | 2 |
| TF | TF:M02063 | Factor: c-ets-1; motif: ACCGGAWGTN | Factor: c-ets-1; motif: ACCGGAWGTN | 76 | 1.110077e-04 | 2 |
| TF | TF:M02071 | Factor: ETV7; motif: NCCGGAANNN | Factor: ETV7; motif: NCCGGAANNN | 91 | 1.237030e-04 | 2 |
| TF | TF:M03975 | Factor: ERG; motif: ACCGGAARTN | Factor: ERG; motif: ACCGGAARTN | 90 | 1.336209e-04 | 2 |
| TF | TF:M01752_1 | Factor: ERG; motif: ACCGGAART; match class: 1 | Factor: ERG; motif: ACCGGAART; match class: 1 | 48 | 1.596106e-04 | 2 |
| TF | TF:M09904_1 | Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 | Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 | 40 | 1.863037e-04 | 2 |
| TF | TF:M11396 | Factor: Erg; motif: NACCGGAARTN | Factor: Erg; motif: NACCGGAARTN | 94 | 2.033149e-04 | 2 |
| TF | TF:M11450 | Factor: Elf-1; motif: NANSCGGAAGTR | Factor: Elf-1; motif: NANSCGGAAGTR | 62 | 2.152224e-04 | 2 |
| TF | TF:M11425_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 36 | 2.345893e-04 | 2 |
| TF | TF:M09607 | Factor: SAP-1; motif: ACCGGAAGTNN | Factor: SAP-1; motif: ACCGGAAGTNN | 55 | 3.300395e-04 | 2 |
| TF | TF:M11428_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 34 | 3.340989e-04 | 2 |
| TF | TF:M02059 | Factor: ELK-1; motif: ACCGGAAGTN | Factor: ELK-1; motif: ACCGGAAGTN | 86 | 3.422540e-04 | 2 |
| TF | TF:M02052_1 | Factor: EHF; motif: CSCGGAARTN; match class: 1 | Factor: EHF; motif: CSCGGAARTN; match class: 1 | 50 | 3.937724e-04 | 2 |
| TF | TF:M03977 | Factor: ETS1; motif: ACCGGAARYN | Factor: ETS1; motif: ACCGGAARYN | 92 | 4.301013e-04 | 2 |
| TF | TF:M02074 | Factor: GABPalpha; motif: RCCGGAWRYN | Factor: GABPalpha; motif: RCCGGAWRYN | 54 | 4.342132e-04 | 2 |
| TF | TF:M02073 | Factor: Fli-1; motif: ACCGGAAGYN | Factor: Fli-1; motif: ACCGGAAGYN | 63 | 4.393120e-04 | 2 |
| TF | TF:M03988 | Factor: FLI1; motif: ACCGGAARTN | Factor: FLI1; motif: ACCGGAARTN | 79 | 4.894651e-04 | 2 |
| TF | TF:M09606 | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | 66 | 4.898877e-04 | 2 |
| TF | TF:M04710_1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | 97 | 4.913026e-04 | 2 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 117 | 5.377332e-04 | 2 |
| TF | TF:M08982 | Factor: YY1; motif: NAANATGGCGNNN | Factor: YY1; motif: NAANATGGCGNNN | 71 | 5.419935e-04 | 2 |
| TF | TF:M02053 | Factor: ELF1; motif: NCCGGAARTN | Factor: ELF1; motif: NCCGGAARTN | 64 | 5.716187e-04 | 2 |
| TF | TF:M12238_1 | Factor: DREF; motif: MTRTCGCGAYAK; match class: 1 | Factor: DREF; motif: MTRTCGCGAYAK; match class: 1 | 12 | 6.623811e-04 | 2 |
| TF | TF:M11425 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 73 | 6.716969e-04 | 2 |
| TF | TF:M04714_1 | Factor: Elf-1; motif: ACTTCCGGG; match class: 1 | Factor: Elf-1; motif: ACTTCCGGG; match class: 1 | 38 | 7.382465e-04 | 2 |
| TF | TF:M07140_1 | Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 | Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 | 10 | 7.524283e-04 | 2 |
| TF | TF:M03983 | Factor: ETV5; motif: NCCGGAWGYN | Factor: ETV5; motif: NCCGGAWGYN | 42 | 8.519905e-04 | 2 |
| TF | TF:M03982 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 69 | 8.610024e-04 | 2 |
| TF | TF:M11404 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 81 | 8.912377e-04 | 2 |
| TF | TF:M12557 | Factor: ETV5; motif: NNACTTCCGNN | Factor: ETV5; motif: NNACTTCCGNN | 52 | 9.428788e-04 | 2 |
| TF | TF:M02044_1 | Factor: YY1; motif: GCCGCCATTTTG; match class: 1 | Factor: YY1; motif: GCCGCCATTTTG; match class: 1 | 24 | 9.589493e-04 | 2 |
| TF | TF:M03988_1 | Factor: FLI1; motif: ACCGGAARTN; match class: 1 | Factor: FLI1; motif: ACCGGAARTN; match class: 1 | 40 | 9.928662e-04 | 2 |
| TF | TF:M01660_1 | Factor: GABP-alpha; motif: CTTCCK; match class: 1 | Factor: GABP-alpha; motif: CTTCCK; match class: 1 | 57 | 1.091164e-03 | 2 |
| TF | TF:M11432_1 | Factor: Elk-1; motif: NACMGGAAGTN; match class: 1 | Factor: Elk-1; motif: NACMGGAAGTN; match class: 1 | 27 | 1.129281e-03 | 2 |
| TF | TF:M09608_1 | Factor: Erg; motif: NNACCGGAARTSN; match class: 1 | Factor: Erg; motif: NNACCGGAARTSN; match class: 1 | 35 | 1.211322e-03 | 2 |
| TF | TF:M08759 | Factor: c-Ets-2; motif: NCCGGAAGTG | Factor: c-Ets-2; motif: NCCGGAAGTG | 78 | 1.300605e-03 | 2 |
| TF | TF:M02044 | Factor: YY1; motif: GCCGCCATTTTG | Factor: YY1; motif: GCCGCCATTTTG | 64 | 1.380431e-03 | 2 |
| TF | TF:M11018 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | 119 | 1.382666e-03 | 2 |
| TF | TF:M09904 | Factor: Elk-1; motif: RCCGGAAGTGN | Factor: Elk-1; motif: RCCGGAAGTGN | 77 | 1.393132e-03 | 2 |
| TF | TF:M08298_1 | Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN; match class: 1 | Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN; match class: 1 | 47 | 1.438533e-03 | 2 |
| TF | TF:M10436 | Factor: YY1; motif: CAANATGGCGGC | Factor: YY1; motif: CAANATGGCGGC | 77 | 1.534547e-03 | 2 |
| TF | TF:M02055_1 | Factor: ESE-1; motif: NSMGGAARTN; match class: 1 | Factor: ESE-1; motif: NSMGGAARTN; match class: 1 | 33 | 1.552261e-03 | 2 |
| TF | TF:M01214_1 | Factor: ESE-1; motif: NSMGGAARTN; match class: 1 | Factor: ESE-1; motif: NSMGGAARTN; match class: 1 | 33 | 1.552261e-03 | 2 |
| TF | TF:M01078 | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN | 73 | 1.639073e-03 | 2 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 115 | 1.669621e-03 | 2 |
| TF | TF:M03970 | Factor: ELK1; motif: ACCGGAAGTN | Factor: ELK1; motif: ACCGGAAGTN | 54 | 1.769175e-03 | 2 |
| TF | TF:M09966_1 | Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 | Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 | 14 | 1.770414e-03 | 2 |
| TF | TF:M11422 | Factor: Erm; motif: NRCMGGAAGTN | Factor: Erm; motif: NRCMGGAAGTN | 53 | 2.042718e-03 | 2 |
| TF | TF:M09900 | Factor: Elf-1; motif: NNANCCGGAAGTGS | Factor: Elf-1; motif: NNANCCGGAAGTGS | 57 | 2.060559e-03 | 2 |
| TF | TF:M00426 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 98 | 2.209797e-03 | 2 |
| TF | TF:M03981 | Factor: ETV3; motif: ACCGGAAGTN | Factor: ETV3; motif: ACCGGAAGTN | 34 | 2.214146e-03 | 2 |
| TF | TF:M11422_1 | Factor: Erm; motif: NRCMGGAAGTN; match class: 1 | Factor: Erm; motif: NRCMGGAAGTN; match class: 1 | 20 | 2.311095e-03 | 2 |
| TF | TF:M10880_1 | Factor: Alx-4; motif: NNCRTTAN; match class: 1 | Factor: Alx-4; motif: NNCRTTAN; match class: 1 | 37 | 2.503709e-03 | 2 |
| TF | TF:M11414 | Factor: GABP-alpha; motif: NACCGGAAGTN | Factor: GABP-alpha; motif: NACCGGAAGTN | 39 | 2.565163e-03 | 2 |
| TF | TF:M11404_1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | 41 | 2.616222e-03 | 2 |
| TF | TF:M01752 | Factor: ERG; motif: ACCGGAART | Factor: ERG; motif: ACCGGAART | 84 | 2.673244e-03 | 2 |
| TF | TF:M11382 | Factor: ESE-1; motif: NWTRCGGAWGCN | Factor: ESE-1; motif: NWTRCGGAWGCN | 89 | 2.693592e-03 | 2 |
| TF | TF:M00426_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 61 | 3.198222e-03 | 2 |
| TF | TF:M01876 | Factor: GABP-beta; motif: ASMGGAAGKGN | Factor: GABP-beta; motif: ASMGGAAGKGN | 32 | 3.359392e-03 | 2 |
| TF | TF:M02071_1 | Factor: ETV7; motif: NCCGGAANNN; match class: 1 | Factor: ETV7; motif: NCCGGAANNN; match class: 1 | 51 | 3.537580e-03 | 2 |
| TF | TF:M10956_1 | Factor: isx; motif: NTCRTTAA; match class: 1 | Factor: isx; motif: NTCRTTAA; match class: 1 | 42 | 4.047023e-03 | 2 |
| TF | TF:M11420 | Factor: ER81; motif: NACCGGAAGTN | Factor: ER81; motif: NACCGGAAGTN | 41 | 4.122362e-03 | 2 |
| TF | TF:M12238 | Factor: DREF; motif: MTRTCGCGAYAK | Factor: DREF; motif: MTRTCGCGAYAK | 12 | 4.192496e-03 | 2 |
| TF | TF:M02068 | Factor: etv3; motif: ACCGGAAGYN | Factor: etv3; motif: ACCGGAAGYN | 43 | 4.286550e-03 | 2 |
| TF | TF:M11419 | Factor: ER81; motif: NNCCGGAWGYN | Factor: ER81; motif: NNCCGGAWGYN | 62 | 4.555894e-03 | 2 |
| TF | TF:M08982_1 | Factor: YY1; motif: NAANATGGCGNNN; match class: 1 | Factor: YY1; motif: NAANATGGCGNNN; match class: 1 | 27 | 4.811018e-03 | 2 |
| TF | TF:M10436_1 | Factor: YY1; motif: CAANATGGCGGC; match class: 1 | Factor: YY1; motif: CAANATGGCGGC; match class: 1 | 33 | 4.860049e-03 | 2 |
| TF | TF:M02053_1 | Factor: ELF1; motif: NCCGGAARTN; match class: 1 | Factor: ELF1; motif: NCCGGAARTN; match class: 1 | 26 | 5.317864e-03 | 2 |
| TF | TF:M09901 | Factor: nerf; motif: NNNCCGGAAGTGN | Factor: nerf; motif: NNNCCGGAAGTGN | 57 | 5.635875e-03 | 2 |
| TF | TF:M11449 | Factor: Elf-1; motif: NANCCGGAAGTN | Factor: Elf-1; motif: NANCCGGAAGTN | 49 | 5.811223e-03 | 2 |
| TF | TF:M01163 | Factor: Elk-1; motif: AACCGGAAGTR | Factor: Elk-1; motif: AACCGGAAGTR | 56 | 6.355173e-03 | 2 |
| TF | TF:M12599 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN | 119 | 6.650087e-03 | 2 |
| TF | TF:M13032 | Factor: ETV5; motif: ACCGGAAGTN | Factor: ETV5; motif: ACCGGAAGTN | 83 | 6.697545e-03 | 2 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 111 | 6.733196e-03 | 2 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 118 | 6.953323e-03 | 2 |
| TF | TF:M11432 | Factor: Elk-1; motif: NACMGGAAGTN | Factor: Elk-1; motif: NACMGGAAGTN | 62 | 6.984861e-03 | 2 |
| TF | TF:M11413 | Factor: ER71; motif: NACCGGAARTN | Factor: ER71; motif: NACCGGAARTN | 31 | 7.032589e-03 | 2 |
| TF | TF:M09894 | Factor: E2F-4; motif: SNGGGCGGGAANN | Factor: E2F-4; motif: SNGGGCGGGAANN | 116 | 7.372897e-03 | 2 |
| TF | TF:M10438 | Factor: ZF5; motif: GGSGCGCGS | Factor: ZF5; motif: GGSGCGCGS | 116 | 7.638207e-03 | 2 |
| TF | TF:M11433 | Factor: Elk-1; motif: NRCCGGAAGTN | Factor: Elk-1; motif: NRCCGGAAGTN | 72 | 7.658895e-03 | 2 |
| TF | TF:M11451_1 | Factor: Elf-1; motif: NANCCGGAAGTN; match class: 1 | Factor: Elf-1; motif: NANCCGGAAGTN; match class: 1 | 31 | 7.748652e-03 | 2 |
| TF | TF:M08917 | Factor: GABP-ALPHA; motif: RCCGGAARTNN | Factor: GABP-ALPHA; motif: RCCGGAARTNN | 36 | 8.005273e-03 | 2 |
| TF | TF:M09608 | Factor: Erg; motif: NNACCGGAARTSN | Factor: Erg; motif: NNACCGGAARTSN | 75 | 8.123881e-03 | 2 |
| TF | TF:M01876_1 | Factor: GABP-beta; motif: ASMGGAAGKGN; match class: 1 | Factor: GABP-beta; motif: ASMGGAAGKGN; match class: 1 | 9 | 8.270340e-03 | 2 |
| TF | TF:M11424 | Factor: Erm; motif: NNSCGGAWGYN | Factor: Erm; motif: NNSCGGAWGYN | 75 | 8.796681e-03 | 2 |
| TF | TF:M03970_1 | Factor: ELK1; motif: ACCGGAAGTN; match class: 1 | Factor: ELK1; motif: ACCGGAAGTN; match class: 1 | 21 | 9.076673e-03 | 2 |
| TF | TF:M13031_1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | 53 | 9.134360e-03 | 2 |
| TF | TF:M11075 | Factor: Sohlh2; motif: NNCACGTGNN | Factor: Sohlh2; motif: NNCACGTGNN | 96 | 9.369810e-03 | 2 |
| TF | TF:M11447_1 | Factor: Elf-1; motif: NAMCCGGAAGTN; match class: 1 | Factor: Elf-1; motif: NAMCCGGAAGTN; match class: 1 | 35 | 9.530311e-03 | 2 |
| TF | TF:M11435_1 | Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 | Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 | 59 | 9.718704e-03 | 2 |
| TF | TF:M02056 | Factor: ELF4; motif: NCCGGAARTN | Factor: ELF4; motif: NCCGGAARTN | 56 | 1.029001e-02 | 2 |
| TF | TF:M04710 | Factor: CHD2; motif: TCTCGCGAG | Factor: CHD2; motif: TCTCGCGAG | 107 | 1.034017e-02 | 2 |
| TF | TF:M08423 | Factor: TEF-3:ER81; motif: ACCGGAAATRCC | Factor: TEF-3:ER81; motif: ACCGGAAATRCC | 45 | 1.081492e-02 | 2 |
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 103 | 1.085891e-02 | 2 |
| TF | TF:M07380 | Factor: E2F-4; motif: NTTTCSCGCC | Factor: E2F-4; motif: NTTTCSCGCC | 102 | 1.160757e-02 | 2 |
| TF | TF:M02072 | Factor: Pet-1; motif: ACCGGAWRTN | Factor: Pet-1; motif: ACCGGAWRTN | 33 | 1.182575e-02 | 2 |
| TF | TF:M03967 | Factor: ELF3; motif: WACCCGGAAGTAN | Factor: ELF3; motif: WACCCGGAAGTAN | 71 | 1.183771e-02 | 2 |
| TF | TF:M02067 | Factor: ER71; motif: ACCGGAARYN | Factor: ER71; motif: ACCGGAARYN | 60 | 1.211535e-02 | 2 |
| TF | TF:M09632_1 | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN; match class: 1 | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN; match class: 1 | 16 | 1.220543e-02 | 2 |
| TF | TF:M12601_1 | Factor: ELF4; motif: NCCACTTCCGGNNNN; match class: 1 | Factor: ELF4; motif: NCCACTTCCGGNNNN; match class: 1 | 25 | 1.222583e-02 | 2 |
| TF | TF:M09905_1 | Factor: SAP-1; motif: NNCCGGAAGTGN; match class: 1 | Factor: SAP-1; motif: NNCCGGAAGTGN; match class: 1 | 38 | 1.230358e-02 | 2 |
| TF | TF:M01165_1 | Factor: Elk-1; motif: RACCGGAAGTR; match class: 1 | Factor: Elk-1; motif: RACCGGAAGTR; match class: 1 | 31 | 1.280821e-02 | 2 |
| TF | TF:M13031 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 90 | 1.285953e-02 | 2 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 111 | 1.292775e-02 | 2 |
| TF | TF:M09605 | Factor: Elf-1; motif: NAANCMGGAAGTGN | Factor: Elf-1; motif: NAANCMGGAAGTGN | 59 | 1.319186e-02 | 2 |
| TF | TF:M08221_1 | Factor: Elk-1:HOXA3; motif: NCCGGAAATKR; match class: 1 | Factor: Elk-1:HOXA3; motif: NCCGGAAATKR; match class: 1 | 44 | 1.426910e-02 | 2 |
| TF | TF:M12601 | Factor: ELF4; motif: NCCACTTCCGGNNNN | Factor: ELF4; motif: NCCACTTCCGGNNNN | 58 | 1.446323e-02 | 2 |
| TF | TF:M12603_1 | Factor: ERM; motif: NNCACTTCCGGNN; match class: 1 | Factor: ERM; motif: NNCACTTCCGGNN; match class: 1 | 29 | 1.482759e-02 | 2 |
| TF | TF:M03990 | Factor: GABPA; motif: ACCGGAAGTN | Factor: GABPA; motif: ACCGGAAGTN | 55 | 1.520608e-02 | 2 |
| TF | TF:M01167 | Factor: SAP-1a; motif: NACCGGAAGTV | Factor: SAP-1a; motif: NACCGGAAGTV | 29 | 1.541632e-02 | 2 |
| TF | TF:M10104 | Factor: YY1; motif: CAARATGGCGGC | Factor: YY1; motif: CAARATGGCGGC | 60 | 1.690429e-02 | 2 |
| TF | TF:M11446 | Factor: Elf-1; motif: RANSMGGAAGTR | Factor: Elf-1; motif: RANSMGGAAGTR | 37 | 1.692547e-02 | 2 |
| TF | TF:M11530 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | 109 | 1.731616e-02 | 2 |
| TF | TF:M02069 | Factor: Erm; motif: ACCGGAAGTN | Factor: Erm; motif: ACCGGAAGTN | 66 | 1.820414e-02 | 2 |
| TF | TF:M11430 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 90 | 1.888759e-02 | 2 |
| TF | TF:M13032_1 | Factor: ETV5; motif: ACCGGAAGTN; match class: 1 | Factor: ETV5; motif: ACCGGAAGTN; match class: 1 | 42 | 1.903976e-02 | 2 |
| TF | TF:M02066 | Factor: PEA3; motif: RCCGGAAGYN | Factor: PEA3; motif: RCCGGAAGYN | 67 | 1.999490e-02 | 2 |
| TF | TF:M00981 | Factor: CREB,; motif: NTGACGTNA | Factor: CREB,; motif: NTGACGTNA | 75 | 2.058079e-02 | 2 |
| TF | TF:M12603 | Factor: ERM; motif: NNCACTTCCGGNN | Factor: ERM; motif: NNCACTTCCGGNN | 67 | 2.153911e-02 | 2 |
| TF | TF:M09607_1 | Factor: SAP-1; motif: ACCGGAAGTNN; match class: 1 | Factor: SAP-1; motif: ACCGGAAGTNN; match class: 1 | 19 | 2.234308e-02 | 2 |
| TF | TF:M12275 | Factor: YY1; motif: NGCCGCCATYTTGN | Factor: YY1; motif: NGCCGCCATYTTGN | 66 | 2.243621e-02 | 2 |
| TF | TF:M02057 | Factor: Elf5; motif: CSMGGAARNN | Factor: Elf5; motif: CSMGGAARNN | 87 | 2.258653e-02 | 2 |
| TF | TF:M03924_1 | Factor: YY1; motif: NNCGCCATTNN; match class: 1 | Factor: YY1; motif: NNCGCCATTNN; match class: 1 | 43 | 2.357735e-02 | 2 |
| TF | TF:M09966 | Factor: Kaiso; motif: SARNYCTCGCGAGAN | Factor: Kaiso; motif: SARNYCTCGCGAGAN | 32 | 2.384023e-02 | 2 |
| TF | TF:M02062_1 | Factor: Erg; motif: ACCGGAAGTN; match class: 1 | Factor: Erg; motif: ACCGGAAGTN; match class: 1 | 35 | 2.415808e-02 | 2 |
| TF | TF:M11882_1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | 93 | 2.596349e-02 | 2 |
| TF | TF:M10591 | Factor: BSX; motif: NNCGTTAN | Factor: BSX; motif: NNCGTTAN | 71 | 2.645806e-02 | 2 |
| TF | TF:M04698 | Factor: GABP-alpha; motif: CACTTCCGG | Factor: GABP-alpha; motif: CACTTCCGG | 39 | 2.688179e-02 | 2 |
| TF | TF:M08205 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | 108 | 2.756786e-02 | 2 |
| TF | TF:M10680 | Factor: HPX42B; motif: CGATTANCG | Factor: HPX42B; motif: CGATTANCG | 22 | 3.059455e-02 | 2 |
| TF | TF:M11533_1 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN; match class: 1 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN; match class: 1 | 77 | 3.322747e-02 | 2 |
| TF | TF:M02059_1 | Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 | Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 | 43 | 3.496701e-02 | 2 |
| TF | TF:M08307 | Factor: GCMa:Elf-1; motif: NRCCCGCACGGAAGTN | Factor: GCMa:Elf-1; motif: NRCCCGCACGGAAGTN | 79 | 3.559394e-02 | 2 |
| TF | TF:M02067_1 | Factor: ER71; motif: ACCGGAARYN; match class: 1 | Factor: ER71; motif: ACCGGAARYN; match class: 1 | 25 | 3.571756e-02 | 2 |
| TF | TF:M00430_1 | Factor: E2F-1; motif: NTTSGCGG; match class: 1 | Factor: E2F-1; motif: NTTSGCGG; match class: 1 | 33 | 3.606657e-02 | 2 |
| TF | TF:M11530_1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | 103 | 3.688482e-02 | 2 |
| TF | TF:M08341 | Factor: HOXB2:Elk-1; motif: TAATKRCCGGAAGTN | Factor: HOXB2:Elk-1; motif: TAATKRCCGGAAGTN | 60 | 3.761945e-02 | 2 |
| TF | TF:M04810 | Factor: USF2; motif: AAGTCACG | Factor: USF2; motif: AAGTCACG | 61 | 3.876212e-02 | 2 |
| TF | TF:M11415 | Factor: GABP-alpha; motif: NRCCGGAAGTN | Factor: GABP-alpha; motif: NRCCGGAAGTN | 39 | 4.027999e-02 | 2 |
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 111 | 4.207250e-02 | 2 |
| TF | TF:M04744_1 | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 | 51 | 4.290237e-02 | 2 |
| TF | TF:M11066_1 | Factor: HES-7; motif: GNCACGYGNN; match class: 1 | Factor: HES-7; motif: GNCACGYGNN; match class: 1 | 73 | 4.592420e-02 | 2 |
| TF | TF:M11005_1 | Factor: LHX4; motif: NNCRTTAN; match class: 1 | Factor: LHX4; motif: NNCRTTAN; match class: 1 | 46 | 4.688812e-02 | 2 |
| TF | TF:M08221 | Factor: Elk-1:HOXA3; motif: NCCGGAAATKR | Factor: Elk-1:HOXA3; motif: NCCGGAAATKR | 86 | 4.757636e-02 | 2 |
| TF | TF:M10625 | Factor: Nkx3-2; motif: NTCGTTAN | Factor: Nkx3-2; motif: NTCGTTAN | 59 | 4.919792e-02 | 2 |
Community 3
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 46 | 2.396465e-47 | 3 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 47 | 4.946214e-38 | 3 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 62 | 6.939087e-35 | 3 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 35 | 6.944912e-34 | 3 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 35 | 1.577537e-33 | 3 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 54 | 2.103740e-26 | 3 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 40 | 5.236088e-26 | 3 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 40 | 6.961718e-26 | 3 |
| GO:CC | GO:0042641 | actomyosin | "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] | 18 | 3.883142e-23 | 3 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 70 | 2.867651e-22 | 3 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 47 | 1.035838e-21 | 3 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 47 | 1.896346e-21 | 3 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 47 | 1.934639e-21 | 3 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 47 | 1.934639e-21 | 3 |
| GO:CC | GO:0032432 | actin filament bundle | "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] | 17 | 3.986704e-21 | 3 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 40 | 4.921178e-21 | 3 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 24 | 5.094405e-21 | 3 |
| GO:CC | GO:0005884 | actin filament | "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] | 18 | 8.502419e-21 | 3 |
| GO:CC | GO:0097517 | contractile actin filament bundle | "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194] | 16 | 4.480337e-20 | 3 |
| GO:CC | GO:0001725 | stress fiber | "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] | 16 | 4.480337e-20 | 3 |
| GO:CC | GO:0030016 | myofibril | "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] | 21 | 9.487684e-20 | 3 |
| GO:CC | GO:0043292 | contractile muscle fiber | "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] | 21 | 2.249770e-19 | 3 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 71 | 4.142940e-18 | 3 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 71 | 4.181960e-18 | 3 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 29 | 4.585728e-17 | 3 |
| GO:CC | GO:0030017 | sarcomere | "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] | 18 | 3.360608e-16 | 3 |
| GO:CC | GO:0030863 | cortical cytoskeleton | "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] | 15 | 4.316907e-16 | 3 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 88 | 4.573903e-15 | 3 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 53 | 1.006573e-14 | 3 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 48 | 2.176981e-14 | 3 |
| GO:CC | GO:0005903 | brush border | "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] | 13 | 2.553088e-13 | 3 |
| GO:CC | GO:0031252 | cell leading edge | "The area of a motile cell closest to the direction of movement." [GOC:pg] | 20 | 2.899152e-13 | 3 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 21 | 9.182351e-13 | 3 |
| GO:CC | GO:0016459 | myosin complex | "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin] | 10 | 1.204393e-11 | 3 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 50 | 1.817320e-11 | 3 |
| GO:CC | GO:0098862 | cluster of actin-based cell projections | "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos] | 13 | 9.111709e-11 | 3 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 36 | 6.987384e-10 | 3 |
| GO:CC | GO:0005865 | striated muscle thin filament | "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] | 7 | 1.154736e-09 | 3 |
| GO:CC | GO:0036379 | myofilament | "Any of the smallest contractile units of a myofibril (striated muscle fiber)." [Wikipedia:Myofilament] | 7 | 4.126887e-09 | 3 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 33 | 2.334841e-08 | 3 |
| GO:CC | GO:0005862 | muscle thin filament tropomyosin | "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194] | 4 | 8.197548e-08 | 3 |
| GO:CC | GO:0002102 | podosome | "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] | 7 | 9.967327e-08 | 3 |
| GO:CC | GO:0005912 | adherens junction | "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264] | 11 | 1.130521e-07 | 3 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 25 | 1.523780e-07 | 3 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 91 | 1.550927e-07 | 3 |
| GO:CC | GO:0016460 | myosin II complex | "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin] | 6 | 3.532303e-07 | 3 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 54 | 5.021293e-07 | 3 |
| GO:CC | GO:0030864 | cortical actin cytoskeleton | "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] | 8 | 7.079970e-07 | 3 |
| GO:CC | GO:0030018 | Z disc | "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] | 9 | 1.211794e-06 | 3 |
| GO:CC | GO:0031674 | I band | "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131] | 9 | 3.123844e-06 | 3 |
| GO:CC | GO:0001726 | ruffle | "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] | 9 | 2.187769e-05 | 3 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 91 | 2.469767e-05 | 3 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 87 | 2.709159e-05 | 3 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 48 | 4.044396e-05 | 3 |
| GO:CC | GO:0030027 | lamellipodium | "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194] | 9 | 5.278541e-05 | 3 |
| GO:CC | GO:0098978 | glutamatergic synapse | "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] | 14 | 5.446365e-05 | 3 |
| GO:CC | GO:0031941 | filamentous actin | "A two-stranded helical polymer of the protein actin." [GOC:mah] | 5 | 7.053529e-05 | 3 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 29 | 7.467076e-05 | 3 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 29 | 7.849929e-05 | 3 |
| GO:CC | GO:0008180 | COP9 signalosome | "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] | 5 | 9.584959e-05 | 3 |
| GO:CC | GO:0098590 | plasma membrane region | "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] | 20 | 1.272363e-04 | 3 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 7 | 1.427321e-04 | 3 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 7 | 1.427321e-04 | 3 |
| GO:CC | GO:0030424 | axon | "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] | 14 | 1.618350e-04 | 3 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 22 | 2.640768e-04 | 3 |
| GO:CC | GO:0072357 | PTW/PP1 phosphatase complex | "A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase." [GOC:mah, PMID:20516061] | 3 | 7.053663e-04 | 3 |
| GO:CC | GO:0014704 | intercalated disc | "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910] | 5 | 7.988278e-04 | 3 |
| GO:CC | GO:0043296 | apical junction complex | "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556] | 7 | 1.123587e-03 | 3 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 63 | 1.240378e-03 | 3 |
| GO:CC | GO:0098858 | actin-based cell projection | "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519] | 8 | 1.650194e-03 | 3 |
| GO:CC | GO:0030175 | filopodium | "Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194] | 6 | 1.652490e-03 | 3 |
| GO:CC | GO:0016461 | unconventional myosin complex | "A portmanteau term for myosins other than myosin II." [GOC:ma] | 3 | 1.682697e-03 | 3 |
| GO:CC | GO:0005916 | fascia adherens | "A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:aruk, GOC:bc, GOC:mtg_muscle, PMID:11732910] | 3 | 1.682697e-03 | 3 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 54 | 2.053106e-03 | 3 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 9 | 2.358958e-03 | 3 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 9 | 2.667883e-03 | 3 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 9 | 2.733654e-03 | 3 |
| GO:CC | GO:0043005 | neuron projection | "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] | 18 | 2.927030e-03 | 3 |
| GO:CC | GO:0005885 | Arp2/3 protein complex | "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800] | 3 | 3.285424e-03 | 3 |
| GO:CC | GO:0044291 | cell-cell contact zone | "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018] | 5 | 4.770389e-03 | 3 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 14 | 4.935819e-03 | 3 |
| GO:CC | GO:0031253 | cell projection membrane | "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah] | 9 | 5.588798e-03 | 3 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 13 | 5.775327e-03 | 3 |
| GO:CC | GO:0150034 | distal axon | "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] | 8 | 6.619387e-03 | 3 |
| GO:CC | GO:0045177 | apical part of cell | "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] | 10 | 8.105723e-03 | 3 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 15 | 1.314664e-02 | 3 |
| GO:CC | GO:0097513 | myosin II filament | "A bipolar filament composed of myosin II molecules." [GOC:cjm, GOC:mah] | 2 | 1.501775e-02 | 3 |
| GO:CC | GO:0043034 | costamere | "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378] | 3 | 1.590881e-02 | 3 |
| GO:CC | GO:0005902 | microvillus | "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194] | 5 | 1.713246e-02 | 3 |
| GO:CC | GO:0000164 | protein phosphatase type 1 complex | "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd] | 3 | 1.883491e-02 | 3 |
| GO:CC | GO:0030426 | growth cone | "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] | 6 | 2.130548e-02 | 3 |
| GO:CC | GO:0032154 | cleavage furrow | "The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409] | 4 | 2.377689e-02 | 3 |
| GO:CC | GO:0030427 | site of polarized growth | "Any part of a cell where non-isotropic growth takes place." [GOC:mah] | 6 | 2.505290e-02 | 3 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 13 | 2.747216e-02 | 3 |
| GO:CC | GO:0071664 | catenin-TCF7L2 complex | "A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:rl, GOC:vk, PMID:14661054] | 2 | 2.995414e-02 | 3 |
| GO:CC | GO:0030139 | endocytic vesicle | "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797] | 8 | 3.161602e-02 | 3 |
| GO:CC | GO:0032982 | myosin filament | "A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah] | 3 | 3.875388e-02 | 3 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 5 | 4.971231e-02 | 3 |
| GO:CC | GO:0097433 | dense body | "An electron dense body which may contain granules." [ISBN:0195065719, NIF_Subcellular:sao730872736] | 2 | 4.978841e-02 | 3 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 48 | 3.839318e-35 | 3 |
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 37 | 1.798038e-34 | 3 |
| GO:MF | GO:0051015 | actin filament binding | "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] | 29 | 1.179520e-32 | 3 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 39 | 1.325441e-19 | 3 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 23 | 3.925991e-18 | 3 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 26 | 1.722491e-16 | 3 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 35 | 2.029904e-09 | 3 |
| GO:MF | GO:0005200 | structural constituent of cytoskeleton | "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] | 11 | 2.717983e-09 | 3 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 92 | 2.983892e-08 | 3 |
| GO:MF | GO:0003774 | cytoskeletal motor activity | "Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)." [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949] | 10 | 7.609019e-08 | 3 |
| GO:MF | GO:0000146 | microfilament motor activity | "A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949] | 7 | 1.878617e-07 | 3 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 18 | 5.386260e-07 | 3 |
| GO:MF | GO:0120544 | polypeptide conformation or assembly isomerase activity | "Catalysis of a reaction that alters the conformation or assembly of a polypeptide." [EC:5.6.1.-] | 9 | 2.704708e-06 | 3 |
| GO:MF | GO:0044325 | transmembrane transporter binding | "Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372] | 9 | 1.175101e-05 | 3 |
| GO:MF | GO:0005516 | calmodulin binding | "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] | 10 | 2.416674e-05 | 3 |
| GO:MF | GO:0005198 | structural molecule activity | "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] | 20 | 6.611326e-05 | 3 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 23 | 2.387918e-04 | 3 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 31 | 3.252703e-04 | 3 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 16 | 3.748742e-04 | 3 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 10 | 5.253462e-04 | 3 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 15 | 5.338233e-04 | 3 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 14 | 5.870769e-04 | 3 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 22 | 6.054887e-04 | 3 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 23 | 6.576281e-04 | 3 |
| GO:MF | GO:0008307 | structural constituent of muscle | "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] | 5 | 8.121875e-04 | 3 |
| GO:MF | GO:0051020 | GTPase binding | "Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai] | 10 | 1.172131e-03 | 3 |
| GO:MF | GO:0099186 | structural constituent of postsynapse | "The action of a molecule that contributes to the structural integrity of a postsynapse." [GOC:dos] | 4 | 2.459304e-03 | 3 |
| GO:MF | GO:0043531 | ADP binding | "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl] | 5 | 2.632918e-03 | 3 |
| GO:MF | GO:0098918 | structural constituent of synapse | "The action of a molecule that contributes to the structural integrity of a synapse." [GOC:dos] | 4 | 4.672607e-03 | 3 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 25 | 5.147078e-03 | 3 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 25 | 5.908836e-03 | 3 |
| GO:MF | GO:0098973 | structural constituent of postsynaptic actin cytoskeleton | "The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton." [GOC:dos] | 3 | 6.547604e-03 | 3 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 25 | 6.826703e-03 | 3 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 9 | 6.892377e-03 | 3 |
| GO:MF | GO:0045294 | alpha-catenin binding | "Binding to catenin complex alpha subunit." [GOC:bf] | 3 | 8.972974e-03 | 3 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 24 | 1.014091e-02 | 3 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 49 | 1.033378e-02 | 3 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 25 | 1.082537e-02 | 3 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 9 | 1.084902e-02 | 3 |
| GO:MF | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | "Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl] | 5 | 2.532223e-02 | 3 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 49 | 2.562245e-02 | 3 |
| GO:MF | GO:0016853 | isomerase activity | "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] | 10 | 2.562527e-02 | 3 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 25 | 3.581628e-02 | 3 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 25 | 4.049594e-02 | 3 |
| GO:MF | GO:0098641 | cadherin binding involved in cell-cell adhesion | "Any cadherin binding that occurs as part of the process of cell-cell adhesion." [GOC:dos] | 3 | 4.335202e-02 | 3 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 10 | 4.853699e-02 | 3 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 41 | 2.230978e-30 | 3 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 49 | 7.101129e-29 | 3 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 38 | 1.878314e-28 | 3 |
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 31 | 1.225654e-25 | 3 |
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 37 | 1.539497e-24 | 3 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 56 | 2.594810e-18 | 3 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] | 21 | 1.437432e-14 | 3 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 22 | 6.516983e-13 | 3 |
| GO:BP | GO:0110053 | regulation of actin filament organization | "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv] | 17 | 2.512974e-12 | 3 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 19 | 5.711136e-12 | 3 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] | 18 | 8.030748e-12 | 3 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 40 | 9.699550e-12 | 3 |
| GO:BP | GO:0030048 | actin filament-based movement | "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] | 13 | 4.727323e-11 | 3 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 26 | 1.360042e-10 | 3 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 27 | 3.365528e-10 | 3 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] | 40 | 3.753498e-10 | 3 |
| GO:BP | GO:0030835 | negative regulation of actin filament depolymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah] | 9 | 4.560212e-10 | 3 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 69 | 7.171058e-10 | 3 |
| GO:BP | GO:0030834 | regulation of actin filament depolymerization | "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] | 9 | 2.762854e-09 | 3 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 69 | 2.943187e-09 | 3 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 58 | 3.333525e-09 | 3 |
| GO:BP | GO:0008064 | regulation of actin polymerization or depolymerization | "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] | 12 | 3.376005e-09 | 3 |
| GO:BP | GO:0030832 | regulation of actin filament length | "Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah] | 12 | 4.298511e-09 | 3 |
| GO:BP | GO:0030042 | actin filament depolymerization | "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] | 9 | 6.524572e-09 | 3 |
| GO:BP | GO:0007155 | cell adhesion | "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] | 29 | 7.423543e-09 | 3 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 60 | 9.969998e-09 | 3 |
| GO:BP | GO:0051693 | actin filament capping | "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] | 8 | 1.281316e-08 | 3 |
| GO:BP | GO:0031032 | actomyosin structure organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] | 13 | 1.452306e-08 | 3 |
| GO:BP | GO:0030833 | regulation of actin filament polymerization | "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] | 11 | 1.730946e-08 | 3 |
| GO:BP | GO:0032272 | negative regulation of protein polymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 9 | 4.967172e-08 | 3 |
| GO:BP | GO:1901880 | negative regulation of protein depolymerization | "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] | 9 | 5.646020e-08 | 3 |
| GO:BP | GO:0008154 | actin polymerization or depolymerization | "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] | 12 | 7.486538e-08 | 3 |
| GO:BP | GO:0032271 | regulation of protein polymerization | "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 12 | 1.208995e-07 | 3 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 38 | 1.304598e-07 | 3 |
| GO:BP | GO:0043242 | negative regulation of protein-containing complex disassembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] | 9 | 1.846278e-07 | 3 |
| GO:BP | GO:0030041 | actin filament polymerization | "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] | 11 | 2.112029e-07 | 3 |
| GO:BP | GO:0051261 | protein depolymerization | "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] | 10 | 2.410200e-07 | 3 |
| GO:BP | GO:0030837 | negative regulation of actin filament polymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] | 8 | 3.000020e-07 | 3 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 42 | 3.020974e-07 | 3 |
| GO:BP | GO:0048870 | cell motility | "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] | 29 | 3.471535e-07 | 3 |
| GO:BP | GO:1901879 | regulation of protein depolymerization | "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] | 9 | 4.281682e-07 | 3 |
| GO:BP | GO:0031333 | negative regulation of protein-containing complex assembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] | 10 | 1.176320e-06 | 3 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 30 | 1.326849e-06 | 3 |
| GO:BP | GO:0000902 | cell morphogenesis | "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] | 21 | 2.134487e-06 | 3 |
| GO:BP | GO:0051494 | negative regulation of cytoskeleton organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 10 | 2.775955e-06 | 3 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 21 | 2.891497e-06 | 3 |
| GO:BP | GO:1902904 | negative regulation of supramolecular fiber organization | "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 10 | 3.145933e-06 | 3 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 17 | 5.460146e-06 | 3 |
| GO:BP | GO:0009888 | tissue development | "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] | 29 | 6.474093e-06 | 3 |
| GO:BP | GO:0006936 | muscle contraction | "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] | 13 | 6.870783e-06 | 3 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] | 14 | 6.914966e-06 | 3 |
| GO:BP | GO:0051258 | protein polymerization | "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] | 12 | 7.132337e-06 | 3 |
| GO:BP | GO:0016477 | cell migration | "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] | 25 | 8.003159e-06 | 3 |
| GO:BP | GO:0043244 | regulation of protein-containing complex disassembly | "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] | 9 | 9.156698e-06 | 3 |
| GO:BP | GO:0022607 | cellular component assembly | "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] | 45 | 2.044340e-05 | 3 |
| GO:BP | GO:0034330 | cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] | 18 | 2.884666e-05 | 3 |
| GO:BP | GO:0032984 | protein-containing complex disassembly | "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah] | 11 | 2.964154e-05 | 3 |
| GO:BP | GO:0048513 | animal organ development | "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] | 35 | 3.463578e-05 | 3 |
| GO:BP | GO:0030239 | myofibril assembly | "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] | 7 | 8.119564e-05 | 3 |
| GO:BP | GO:0030155 | regulation of cell adhesion | "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah] | 17 | 8.731629e-05 | 3 |
| GO:BP | GO:0032535 | regulation of cellular component size | "A process that modulates the size of a cellular component." [GOC:mah] | 12 | 8.783811e-05 | 3 |
| GO:BP | GO:0060429 | epithelium development | "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] | 21 | 9.701903e-05 | 3 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 50 | 9.838413e-05 | 3 |
| GO:BP | GO:0003012 | muscle system process | "An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] | 13 | 1.015270e-04 | 3 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 18 | 1.038279e-04 | 3 |
| GO:BP | GO:0021762 | substantia nigra development | "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420] | 6 | 1.100821e-04 | 3 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 35 | 1.118834e-04 | 3 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 45 | 1.157957e-04 | 3 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 32 | 1.277183e-04 | 3 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 32 | 1.415252e-04 | 3 |
| GO:BP | GO:0032501 | multicellular organismal process | "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] | 56 | 2.319929e-04 | 3 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] | 20 | 2.855688e-04 | 3 |
| GO:BP | GO:0030901 | midbrain development | "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [PMID:4975589, PMID:4992177] | 7 | 3.317687e-04 | 3 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 26 | 4.035343e-04 | 3 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] | 7 | 4.131068e-04 | 3 |
| GO:BP | GO:0034329 | cell junction assembly | "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah] | 13 | 5.019506e-04 | 3 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 15 | 6.156410e-04 | 3 |
| GO:BP | GO:0034109 | homotypic cell-cell adhesion | "The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add] | 7 | 6.269080e-04 | 3 |
| GO:BP | GO:0150115 | cell-substrate junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 7 | 6.702993e-04 | 3 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 50 | 6.903226e-04 | 3 |
| GO:BP | GO:0031589 | cell-substrate adhesion | "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf] | 11 | 8.051319e-04 | 3 |
| GO:BP | GO:0045216 | cell-cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 9 | 8.102626e-04 | 3 |
| GO:BP | GO:0002064 | epithelial cell development | "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] | 9 | 9.462318e-04 | 3 |
| GO:BP | GO:0051017 | actin filament bundle assembly | "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] | 8 | 9.793041e-04 | 3 |
| GO:BP | GO:0048731 | system development | "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] | 38 | 1.078620e-03 | 3 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 31 | 1.087514e-03 | 3 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah] | 7 | 1.117672e-03 | 3 |
| GO:BP | GO:0061572 | actin filament bundle organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] | 8 | 1.128180e-03 | 3 |
| GO:BP | GO:0048857 | neural nucleus development | "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021] | 6 | 1.242365e-03 | 3 |
| GO:BP | GO:0030154 | cell differentiation | "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] | 40 | 1.260583e-03 | 3 |
| GO:BP | GO:0048869 | cellular developmental process | "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] | 40 | 1.268380e-03 | 3 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] | 22 | 1.468805e-03 | 3 |
| GO:BP | GO:0007399 | nervous system development | "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] | 29 | 1.519958e-03 | 3 |
| GO:BP | GO:0051014 | actin filament severing | "The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234] | 4 | 1.626894e-03 | 3 |
| GO:BP | GO:0098609 | cell-cell adhesion | "The attachment of one cell to another cell via adhesion molecules." [GOC:dos] | 17 | 1.627117e-03 | 3 |
| GO:BP | GO:0070527 | platelet aggregation | "The adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF, GOC:vk] | 6 | 2.029362e-03 | 3 |
| GO:BP | GO:0030030 | cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917] | 22 | 2.303074e-03 | 3 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 41 | 2.373075e-03 | 3 |
| GO:BP | GO:0051656 | establishment of organelle localization | "The directed movement of an organelle to a specific location." [GOC:ai] | 12 | 2.746741e-03 | 3 |
| GO:BP | GO:0051495 | positive regulation of cytoskeleton organization | "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 8 | 3.060548e-03 | 3 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb] | 12 | 3.318914e-03 | 3 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 45 | 3.334382e-03 | 3 |
| GO:BP | GO:0048729 | tissue morphogenesis | "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] | 13 | 4.702402e-03 | 3 |
| GO:BP | GO:0010927 | cellular component assembly involved in morphogenesis | "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] | 7 | 4.856898e-03 | 3 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system." [GOC:dph, GOC:mah, GOC:tb] | 7 | 4.856898e-03 | 3 |
| GO:BP | GO:0055001 | muscle cell development | "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol] | 8 | 4.886448e-03 | 3 |
| GO:BP | GO:0150105 | protein localization to cell-cell junction | "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] | 4 | 4.919134e-03 | 3 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 11 | 5.107087e-03 | 3 |
| GO:BP | GO:0065007 | biological regulation | "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 75 | 5.896492e-03 | 3 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 10 | 6.036212e-03 | 3 |
| GO:BP | GO:0022411 | cellular component disassembly | "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] | 11 | 7.253917e-03 | 3 |
| GO:BP | GO:0030855 | epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] | 14 | 7.498892e-03 | 3 |
| GO:BP | GO:0051016 | barbed-end actin filament capping | "The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] | 4 | 8.423679e-03 | 3 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 20 | 9.144049e-03 | 3 |
| GO:BP | GO:0007043 | cell-cell junction assembly | "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] | 7 | 1.096324e-02 | 3 |
| GO:BP | GO:0050789 | regulation of biological process | "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] | 73 | 1.110447e-02 | 3 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 21 | 1.217411e-02 | 3 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 15 | 1.226462e-02 | 3 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 44 | 1.357360e-02 | 3 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 18 | 1.527645e-02 | 3 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] | 8 | 1.678051e-02 | 3 |
| GO:BP | GO:0061061 | muscle structure development | "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph] | 13 | 1.751030e-02 | 3 |
| GO:BP | GO:0050793 | regulation of developmental process | "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] | 26 | 1.820559e-02 | 3 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 11 | 1.841248e-02 | 3 |
| GO:BP | GO:0007160 | cell-matrix adhesion | "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] | 8 | 1.841686e-02 | 3 |
| GO:BP | GO:0055002 | striated muscle cell development | "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol] | 7 | 2.003630e-02 | 3 |
| GO:BP | GO:0030050 | vesicle transport along actin filament | "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] | 3 | 2.023906e-02 | 3 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 71 | 2.057549e-02 | 3 |
| GO:BP | GO:0042692 | muscle cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] | 10 | 2.075669e-02 | 3 |
| GO:BP | GO:0006897 | endocytosis | "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis] | 13 | 2.234641e-02 | 3 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] | 11 | 2.265693e-02 | 3 |
| GO:BP | GO:0022604 | regulation of cell morphogenesis | "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete] | 8 | 2.415808e-02 | 3 |
| GO:BP | GO:1902905 | positive regulation of supramolecular fiber organization | "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 7 | 2.509097e-02 | 3 |
| GO:BP | GO:0051640 | organelle localization | "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] | 12 | 2.967744e-02 | 3 |
| GO:BP | GO:0022008 | neurogenesis | "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] | 21 | 3.203623e-02 | 3 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 44 | 3.655399e-02 | 3 |
| GO:BP | GO:0099515 | actin filament-based transport | "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb] | 3 | 3.687526e-02 | 3 |
| GO:BP | GO:0042060 | wound healing | "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] | 10 | 3.700975e-02 | 3 |
| GO:BP | GO:1901888 | regulation of cell junction assembly | "Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] | 8 | 3.916235e-02 | 3 |
| GO:BP | GO:1903921 | regulation of protein processing in phagocytic vesicle | "Any process that modulates the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] | 2 | 4.118008e-02 | 3 |
| GO:BP | GO:1900756 | protein processing in phagocytic vesicle | "Protein processing that takes place in the phagosome. Most protein processing in the phagosome represents protein degradation." [GOC:rjd, GOC:TermGenie] | 2 | 4.118008e-02 | 3 |
| GO:BP | GO:1903923 | positive regulation of protein processing in phagocytic vesicle | "Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] | 2 | 4.118008e-02 | 3 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 18 | 4.289505e-02 | 3 |
| GO:BP | GO:0034333 | adherens junction assembly | "The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:mah] | 3 | 4.778928e-02 | 3 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 38 | 1.423383e-24 | 3 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 38 | 3.103703e-24 | 3 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 50 | 1.535669e-14 | 3 |
| REAC | REAC:R-HSA-195258 | RHO GTPase Effectors | RHO GTPase Effectors | 21 | 1.487800e-13 | 3 |
| REAC | REAC:R-HSA-9012999 | RHO GTPase cycle | RHO GTPase cycle | 20 | 1.436903e-09 | 3 |
| REAC | REAC:R-HSA-2682334 | EPH-Ephrin signaling | EPH-Ephrin signaling | 11 | 4.077563e-09 | 3 |
| REAC | REAC:R-HSA-5625740 | RHO GTPases activate PKNs | RHO GTPases activate PKNs | 11 | 5.885238e-09 | 3 |
| REAC | REAC:R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 10 | 1.029203e-08 | 3 |
| REAC | REAC:R-HSA-5627123 | RHO GTPases activate PAKs | RHO GTPases activate PAKs | 7 | 1.512692e-08 | 3 |
| REAC | REAC:R-HSA-9706574 | RHOBTB GTPase Cycle | RHOBTB GTPase Cycle | 8 | 1.667393e-08 | 3 |
| REAC | REAC:R-HSA-390522 | Striated Muscle Contraction | Striated Muscle Contraction | 8 | 2.132868e-08 | 3 |
| REAC | REAC:R-HSA-9013418 | RHOBTB2 GTPase cycle | RHOBTB2 GTPase cycle | 7 | 3.156861e-08 | 3 |
| REAC | REAC:R-HSA-445355 | Smooth Muscle Contraction | Smooth Muscle Contraction | 8 | 9.861742e-08 | 3 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 18 | 9.998825e-08 | 3 |
| REAC | REAC:R-HSA-199991 | Membrane Trafficking | Membrane Trafficking | 20 | 5.379086e-07 | 3 |
| REAC | REAC:R-HSA-5625900 | RHO GTPases activate CIT | RHO GTPases activate CIT | 6 | 6.004813e-07 | 3 |
| REAC | REAC:R-HSA-5627117 | RHO GTPases Activate ROCKs | RHO GTPases Activate ROCKs | 6 | 6.004813e-07 | 3 |
| REAC | REAC:R-HSA-1500931 | Cell-Cell communication | Cell-Cell communication | 11 | 1.078061e-06 | 3 |
| REAC | REAC:R-HSA-9013424 | RHOV GTPase cycle | RHOV GTPase cycle | 7 | 1.234291e-06 | 3 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 33 | 1.969625e-06 | 3 |
| REAC | REAC:R-HSA-397014 | Muscle contraction | Muscle contraction | 12 | 2.250409e-06 | 3 |
| REAC | REAC:R-HSA-190873 | Gap junction degradation | Gap junction degradation | 5 | 3.012897e-06 | 3 |
| REAC | REAC:R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 5 | 3.012897e-06 | 3 |
| REAC | REAC:R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 5 | 4.871487e-06 | 3 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 11 | 5.805426e-06 | 3 |
| REAC | REAC:R-HSA-5653656 | Vesicle-mediated transport | Vesicle-mediated transport | 20 | 5.957879e-06 | 3 |
| REAC | REAC:R-HSA-9659379 | Sensory processing of sound | Sensory processing of sound | 8 | 8.748242e-06 | 3 |
| REAC | REAC:R-HSA-111447 | Activation of BAD and translocation to mitochondria | Activation of BAD and translocation to mitochondria | 5 | 1.125347e-05 | 3 |
| REAC | REAC:R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 5 | 1.125347e-05 | 3 |
| REAC | REAC:R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | Sensory processing of sound by outer hair cells of the cochlea | 7 | 1.703033e-05 | 3 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 11 | 3.260478e-05 | 3 |
| REAC | REAC:R-HSA-9013420 | RHOU GTPase cycle | RHOU GTPase cycle | 6 | 6.523779e-05 | 3 |
| REAC | REAC:R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | Sensory processing of sound by inner hair cells of the cochlea | 7 | 8.051926e-05 | 3 |
| REAC | REAC:R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | Fcgamma receptor (FCGR) dependent phagocytosis | 9 | 1.046328e-04 | 3 |
| REAC | REAC:R-HSA-196025 | Formation of annular gap junctions | Formation of annular gap junctions | 4 | 2.062927e-04 | 3 |
| REAC | REAC:R-HSA-9664417 | Leishmania phagocytosis | Leishmania phagocytosis | 8 | 2.433371e-04 | 3 |
| REAC | REAC:R-HSA-9664407 | Parasite infection | Parasite infection | 8 | 2.433371e-04 | 3 |
| REAC | REAC:R-HSA-9664422 | FCGR3A-mediated phagocytosis | FCGR3A-mediated phagocytosis | 8 | 2.433371e-04 | 3 |
| REAC | REAC:R-HSA-446728 | Cell junction organization | Cell junction organization | 8 | 2.603674e-04 | 3 |
| REAC | REAC:R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | Regulation of actin dynamics for phagocytic cup formation | 8 | 2.975045e-04 | 3 |
| REAC | REAC:R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | Caspase-mediated cleavage of cytoskeletal proteins | 4 | 3.079326e-04 | 3 |
| REAC | REAC:R-HSA-3928663 | EPHA-mediated growth cone collapse | EPHA-mediated growth cone collapse | 5 | 3.450836e-04 | 3 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 7 | 4.631538e-04 | 3 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 5 | 4.953876e-04 | 3 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 15 | 5.906096e-04 | 3 |
| REAC | REAC:R-HSA-9700206 | Signaling by ALK in cancer | Signaling by ALK in cancer | 7 | 6.334814e-04 | 3 |
| REAC | REAC:R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | Signaling by ALK fusions and activated point mutants | 7 | 6.334814e-04 | 3 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 21 | 7.833129e-04 | 3 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 15 | 1.033876e-03 | 3 |
| REAC | REAC:R-HSA-111465 | Apoptotic cleavage of cellular proteins | Apoptotic cleavage of cellular proteins | 5 | 1.463138e-03 | 3 |
| REAC | REAC:R-HSA-446353 | Cell-extracellular matrix interactions | Cell-extracellular matrix interactions | 4 | 1.848677e-03 | 3 |
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 30 | 1.987814e-03 | 3 |
| REAC | REAC:R-HSA-3928662 | EPHB-mediated forward signaling | EPHB-mediated forward signaling | 5 | 2.175785e-03 | 3 |
| REAC | REAC:R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | Sema4D induced cell migration and growth-cone collapse | 4 | 2.898670e-03 | 3 |
| REAC | REAC:R-HSA-9824443 | Parasitic Infection Pathways | Parasitic Infection Pathways | 9 | 3.580583e-03 | 3 |
| REAC | REAC:R-HSA-9658195 | Leishmania infection | Leishmania infection | 9 | 3.580583e-03 | 3 |
| REAC | REAC:R-HSA-373753 | Nephrin family interactions | Nephrin family interactions | 4 | 5.220878e-03 | 3 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 20 | 5.295173e-03 | 3 |
| REAC | REAC:R-HSA-6802957 | Oncogenic MAPK signaling | Oncogenic MAPK signaling | 6 | 5.630066e-03 | 3 |
| REAC | REAC:R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | EPH-ephrin mediated repulsion of cells | 5 | 6.027931e-03 | 3 |
| REAC | REAC:R-HSA-190828 | Gap junction trafficking | Gap junction trafficking | 5 | 6.027931e-03 | 3 |
| REAC | REAC:R-HSA-400685 | Sema4D in semaphorin signaling | Sema4D in semaphorin signaling | 4 | 6.234602e-03 | 3 |
| REAC | REAC:R-HSA-157858 | Gap junction trafficking and regulation | Gap junction trafficking and regulation | 5 | 6.664313e-03 | 3 |
| REAC | REAC:R-HSA-75153 | Apoptotic execution phase | Apoptotic execution phase | 5 | 7.351864e-03 | 3 |
| REAC | REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | Intrinsic Pathway for Apoptosis | 5 | 9.750470e-03 | 3 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 8 | 1.453706e-02 | 3 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 8 | 1.562963e-02 | 3 |
| REAC | REAC:R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | Entry of Influenza Virion into Host Cell via Endocytosis | 2 | 1.668628e-02 | 3 |
| REAC | REAC:R-HSA-445095 | Interaction between L1 and Ankyrins | Interaction between L1 and Ankyrins | 4 | 1.784276e-02 | 3 |
| REAC | REAC:R-HSA-5626467 | RHO GTPases activate IQGAPs | RHO GTPases activate IQGAPs | 4 | 2.029272e-02 | 3 |
| REAC | REAC:R-HSA-9614399 | Regulation of localization of FOXO transcription factors | Regulation of localization of FOXO transcription factors | 3 | 2.208079e-02 | 3 |
| REAC | REAC:R-HSA-373755 | Semaphorin interactions | Semaphorin interactions | 5 | 2.236234e-02 | 3 |
| REAC | REAC:R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | Signaling by BRAF and RAF1 fusions | 5 | 2.236234e-02 | 3 |
| REAC | REAC:R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | Signaling by high-kinase activity BRAF mutants | 4 | 2.911927e-02 | 3 |
| REAC | REAC:R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs | RHO GTPases Activate WASPs and WAVEs | 4 | 2.911927e-02 | 3 |
| REAC | REAC:R-HSA-380259 | Loss of Nlp from mitotic centrosomes | Loss of Nlp from mitotic centrosomes | 5 | 2.996914e-02 | 3 |
| REAC | REAC:R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome | Loss of proteins required for interphase microtubule organization from the centrosome | 5 | 2.996914e-02 | 3 |
| REAC | REAC:R-HSA-8854518 | AURKA Activation by TPX2 | AURKA Activation by TPX2 | 5 | 3.687578e-02 | 3 |
| REAC | REAC:R-HSA-5674135 | MAP2K and MAPK activation | MAP2K and MAPK activation | 4 | 4.486145e-02 | 3 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 21 | 4.578395e-02 | 3 |
| REAC | REAC:R-HSA-373760 | L1CAM interactions | L1CAM interactions | 6 | 4.626286e-02 | 3 |
| REAC | REAC:R-HSA-9656223 | Signaling by RAF1 mutants | Signaling by RAF1 mutants | 4 | 4.960431e-02 | 3 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04814 | Motor proteins | Motor proteins | 19 | 7.553367e-15 | 3 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 16 | 5.422381e-10 | 3 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 15 | 2.553813e-08 | 3 |
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 12 | 1.290644e-07 | 3 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | Bacterial invasion of epithelial cells | 9 | 4.063846e-07 | 3 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 12 | 1.707979e-06 | 3 |
| KEGG | KEGG:04520 | Adherens junction | Adherens junction | 9 | 2.205458e-06 | 3 |
| KEGG | KEGG:04530 | Tight junction | Tight junction | 11 | 3.820681e-06 | 3 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | Proteoglycans in cancer | 11 | 2.588270e-05 | 3 |
| KEGG | KEGG:04510 | Focal adhesion | Focal adhesion | 10 | 1.972863e-04 | 3 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 8 | 4.756874e-04 | 3 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | Vascular smooth muscle contraction | 8 | 5.324548e-04 | 3 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 9 | 1.493198e-03 | 3 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 8 | 1.885984e-03 | 3 |
| KEGG | KEGG:04611 | Platelet activation | Platelet activation | 7 | 3.188496e-03 | 3 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | Hypertrophic cardiomyopathy | 6 | 7.151724e-03 | 3 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 9 | 7.293021e-03 | 3 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | Dilated cardiomyopathy | 6 | 9.463750e-03 | 3 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | Adrenergic signaling in cardiomyocytes | 7 | 1.209299e-02 | 3 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | Oxytocin signaling pathway | 7 | 1.259430e-02 | 3 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | Leukocyte transendothelial migration | 6 | 1.747004e-02 | 3 |
| KEGG | KEGG:05135 | Yersinia infection | Yersinia infection | 6 | 4.525233e-02 | 3 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | Fluid shear stress and atherosclerosis | 6 | 4.889998e-02 | 3 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 27 | 8.560180e-09 | 3 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 21 | 5.451936e-07 | 3 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 22 | 5.747016e-06 | 3 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 19 | 5.906903e-06 | 3 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 61 | 8.063147e-06 | 3 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 22 | 1.442969e-05 | 3 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 13 | 8.140054e-05 | 3 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 23 | 1.015452e-04 | 3 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 69 | 2.911017e-04 | 3 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 68 | 4.495584e-04 | 3 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 19 | 6.358523e-04 | 3 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 67 | 8.268356e-04 | 3 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 47 | 9.137303e-04 | 3 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 68 | 9.384406e-04 | 3 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 57 | 9.697825e-04 | 3 |
| HPA | HPA:0031323 | Appendix; enterocytes - Microvilli[High] | Appendix; enterocytes - Microvilli[High] | 7 | 1.036910e-03 | 3 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 19 | 1.111663e-03 | 3 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 55 | 1.160028e-03 | 3 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 60 | 1.795133e-03 | 3 |
| HPA | HPA:0400000 | Rectum | Rectum | 73 | 1.951610e-03 | 3 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 19 | 2.124540e-03 | 3 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 72 | 2.243031e-03 | 3 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 70 | 2.265783e-03 | 3 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 20 | 2.393651e-03 | 3 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 71 | 2.464920e-03 | 3 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 71 | 2.464920e-03 | 3 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 68 | 2.532649e-03 | 3 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 69 | 2.632311e-03 | 3 |
| HPA | HPA:0401321 | Rectum; enterocytes - Microvilli[≥Low] | Rectum; enterocytes - Microvilli[≥Low] | 9 | 2.740289e-03 | 3 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 16 | 2.939226e-03 | 3 |
| HPA | HPA:0400201 | Rectum; endothelial cells[≥Low] | Rectum; endothelial cells[≥Low] | 10 | 3.064779e-03 | 3 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 16 | 3.555528e-03 | 3 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 52 | 3.970028e-03 | 3 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 59 | 4.293869e-03 | 3 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 55 | 5.571159e-03 | 3 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 13 | 5.851912e-03 | 3 |
| HPA | HPA:0050000 | Breast | Breast | 68 | 6.105392e-03 | 3 |
| HPA | HPA:0031322 | Appendix; enterocytes - Microvilli[≥Medium] | Appendix; enterocytes - Microvilli[≥Medium] | 8 | 7.358077e-03 | 3 |
| HPA | HPA:0030432 | Appendix; germinal center cells[≥Medium] | Appendix; germinal center cells[≥Medium] | 9 | 7.846168e-03 | 3 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 17 | 8.163221e-03 | 3 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 18 | 9.310577e-03 | 3 |
| HPA | HPA:0401322 | Rectum; enterocytes - Microvilli[≥Medium] | Rectum; enterocytes - Microvilli[≥Medium] | 8 | 9.404468e-03 | 3 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 14 | 9.652850e-03 | 3 |
| HPA | HPA:0030433 | Appendix; germinal center cells[High] | Appendix; germinal center cells[High] | 6 | 1.109001e-02 | 3 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 15 | 1.112366e-02 | 3 |
| HPA | HPA:0030000 | Appendix | Appendix | 71 | 1.179871e-02 | 3 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 69 | 1.237922e-02 | 3 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 70 | 1.326161e-02 | 3 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 70 | 1.326161e-02 | 3 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 58 | 1.465091e-02 | 3 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 65 | 1.576999e-02 | 3 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 64 | 1.608464e-02 | 3 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 9 | 1.617634e-02 | 3 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 9 | 1.617634e-02 | 3 |
| HPA | HPA:0380000 | Placenta | Placenta | 69 | 1.675915e-02 | 3 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 58 | 2.034188e-02 | 3 |
| HPA | HPA:0031321 | Appendix; enterocytes - Microvilli[≥Low] | Appendix; enterocytes - Microvilli[≥Low] | 8 | 2.068497e-02 | 3 |
| HPA | HPA:0300000 | Lung | Lung | 68 | 2.117232e-02 | 3 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 56 | 2.154681e-02 | 3 |
| HPA | HPA:0131323 | Colon; enterocytes - Microvilli[High] | Colon; enterocytes - Microvilli[High] | 6 | 2.344691e-02 | 3 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 9 | 2.465300e-02 | 3 |
| HPA | HPA:0401323 | Rectum; enterocytes - Microvilli[High] | Rectum; enterocytes - Microvilli[High] | 6 | 2.472700e-02 | 3 |
| HPA | HPA:0130000 | Colon | Colon | 73 | 2.539860e-02 | 3 |
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 45 | 2.689346e-02 | 3 |
| HPA | HPA:0131322 | Colon; enterocytes - Microvilli[≥Medium] | Colon; enterocytes - Microvilli[≥Medium] | 8 | 2.722687e-02 | 3 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 61 | 2.820103e-02 | 3 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 61 | 2.820103e-02 | 3 |
| HPA | HPA:0481321 | Small intestine; enterocytes - Microvilli[≥Low] | Small intestine; enterocytes - Microvilli[≥Low] | 9 | 2.928814e-02 | 3 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 59 | 2.997406e-02 | 3 |
| HPA | HPA:0380202 | Placenta; endothelial cells[≥Medium] | Placenta; endothelial cells[≥Medium] | 10 | 3.117685e-02 | 3 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 10 | 3.195105e-02 | 3 |
| HPA | HPA:0630000 | Cervix | Cervix | 65 | 3.202533e-02 | 3 |
| HPA | HPA:0291162 | Liver; cholangiocytes[≥Medium] | Liver; cholangiocytes[≥Medium] | 28 | 3.265140e-02 | 3 |
| HPA | HPA:0381191 | Placenta; cytotrophoblasts[≥Low] | Placenta; cytotrophoblasts[≥Low] | 12 | 3.272181e-02 | 3 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 37 | 3.312305e-02 | 3 |
| HPA | HPA:0380201 | Placenta; endothelial cells[≥Low] | Placenta; endothelial cells[≥Low] | 11 | 3.334663e-02 | 3 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 50 | 3.528982e-02 | 3 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 13 | 3.629017e-02 | 3 |
| HPA | HPA:0131321 | Colon; enterocytes - Microvilli[≥Low] | Colon; enterocytes - Microvilli[≥Low] | 8 | 4.277189e-02 | 3 |
| HPA | HPA:0030431 | Appendix; germinal center cells[≥Low] | Appendix; germinal center cells[≥Low] | 9 | 4.779528e-02 | 3 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP383 | Striated muscle contraction pathway | Striated muscle contraction pathway | 8 | 1.020640e-07 | 3 |
| WP | WP:WP5376 | 17p13 3 YWHAE copy number variation | 17p13 3 YWHAE copy number variation | 6 | 2.228237e-06 | 3 |
| WP | WP:WP2272 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 8 | 2.274047e-06 | 3 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 17 | 8.314171e-06 | 3 |
| WP | WP:WP289 | Myometrial relaxation and contraction pathways | Myometrial relaxation and contraction pathways | 10 | 8.066633e-05 | 3 |
| WP | WP:WP4534 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms | 6 | 3.270840e-04 | 3 |
| WP | WP:WP2572 | Primary focal segmental glomerulosclerosis FSGS | Primary focal segmental glomerulosclerosis FSGS | 7 | 3.292468e-04 | 3 |
| WP | WP:WP51 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 9 | 5.813914e-04 | 3 |
| WP | WP:WP306 | Focal adhesion | Focal adhesion | 10 | 7.996122e-04 | 3 |
| WP | WP:WP4217 | Ebola virus infection in host | Ebola virus infection in host | 8 | 1.657067e-03 | 3 |
| WP | WP:WP2005 | miR targeted genes in muscle cell | miR targeted genes in muscle cell | 11 | 2.180489e-02 | 3 |
| WP | WP:WP2814 | Mammary gland development puberty stage 2 of 4 | Mammary gland development puberty stage 2 of 4 | 3 | 2.598024e-02 | 3 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5199 | Kinase maturation complex 1 | Kinase maturation complex 1 | 6 | 0.000007 | 3 |
| CORUM | CORUM:5604 | Emerin complex 1 | Emerin complex 1 | 4 | 0.000484 | 3 |
| CORUM | CORUM:5615 | Emerin complex 52 | Emerin complex 52 | 4 | 0.024180 | 3 |
| CORUM | CORUM:817 | MRIP-MBS complex | MRIP-MBS complex | 2 | 0.049952 | 3 |
| CORUM | CORUM:2254 | CTGF/Hcs24-actin(beta/gamma) complex | CTGF/Hcs24-actin(beta/gamma) complex | 2 | 0.049952 | 3 |
| CORUM | CORUM:7312 | CTNNB1-ESR1 complex | CTNNB1-ESR1 complex | 2 | 0.049952 | 3 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M03567_1 | Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 | Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 | 42 | 0.000012 | 3 |
| TF | TF:M12227_1 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 | 55 | 0.000022 | 3 |
| TF | TF:M13127_1 | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS; match class: 1 | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS; match class: 1 | 67 | 0.000035 | 3 |
| TF | TF:M00189_1 | Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 | Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 | 55 | 0.000063 | 3 |
| TF | TF:M05327 | Factor: WT1; motif: NGCGGGGGGGTSMMCYN | Factor: WT1; motif: NGCGGGGGGGTSMMCYN | 52 | 0.000072 | 3 |
| TF | TF:M08878 | Factor: EGR; motif: CGCCCCCGCNN | Factor: EGR; motif: CGCCCCCGCNN | 62 | 0.000091 | 3 |
| TF | TF:M03807_1 | Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 | Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 | 44 | 0.000094 | 3 |
| TF | TF:M05361_1 | Factor: Sp6; motif: WGGGCGG; match class: 1 | Factor: Sp6; motif: WGGGCGG; match class: 1 | 38 | 0.000137 | 3 |
| TF | TF:M05444_1 | Factor: CPBP; motif: NGGGCGG; match class: 1 | Factor: CPBP; motif: NGGGCGG; match class: 1 | 38 | 0.000137 | 3 |
| TF | TF:M05332_1 | Factor: Sp2; motif: WGGGCGG; match class: 1 | Factor: Sp2; motif: WGGGCGG; match class: 1 | 38 | 0.000137 | 3 |
| TF | TF:M02089_1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | 70 | 0.000236 | 3 |
| TF | TF:M13124_1 | Factor: ZNF670; motif: SNGGGCRGRG; match class: 1 | Factor: ZNF670; motif: SNGGGCRGRG; match class: 1 | 63 | 0.001265 | 3 |
| TF | TF:M01104_1 | Factor: MOVO-B; motif: GNGGGGG; match class: 1 | Factor: MOVO-B; motif: GNGGGGG; match class: 1 | 50 | 0.001395 | 3 |
| TF | TF:M12722_1 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1 | 55 | 0.001836 | 3 |
| TF | TF:M00933_1 | Factor: Sp1; motif: CCCCGCCCCN; match class: 1 | Factor: Sp1; motif: CCCCGCCCCN; match class: 1 | 47 | 0.002110 | 3 |
| TF | TF:M07277_1 | Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 | Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 | 41 | 0.002431 | 3 |
| TF | TF:M00196_1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | 51 | 0.002511 | 3 |
| TF | TF:M12694_1 | Factor: ZFP14; motif: SCNNYCCNGNNSCTSCNC; match class: 1 | Factor: ZFP14; motif: SCNNYCCNGNNSCTSCNC; match class: 1 | 46 | 0.003388 | 3 |
| TF | TF:M09970_1 | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 | 38 | 0.004256 | 3 |
| TF | TF:M00469 | Factor: AP-2alpha; motif: GCCNNNRGS | Factor: AP-2alpha; motif: GCCNNNRGS | 46 | 0.004502 | 3 |
| TF | TF:M00695_1 | Factor: ETF; motif: GVGGMGG; match class: 1 | Factor: ETF; motif: GVGGMGG; match class: 1 | 56 | 0.004750 | 3 |
| TF | TF:M09734 | Factor: ZNF692; motif: SYNGGSCCCASCCNC | Factor: ZNF692; motif: SYNGGSCCCASCCNC | 77 | 0.004796 | 3 |
| TF | TF:M10072_1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | 52 | 0.005065 | 3 |
| TF | TF:M00446_1 | Factor: Spz1; motif: DNNGGRGGGWWNNNN; match class: 1 | Factor: Spz1; motif: DNNGGRGGGWWNNNN; match class: 1 | 32 | 0.005283 | 3 |
| TF | TF:M09826_1 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 | 59 | 0.006381 | 3 |
| TF | TF:M00931_1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | 50 | 0.006431 | 3 |
| TF | TF:M10435 | Factor: Sp2; motif: GGGGCGGGG | Factor: Sp2; motif: GGGGCGGGG | 59 | 0.007054 | 3 |
| TF | TF:M01303_1 | Factor: SP1; motif: GGGGYGGGGNS; match class: 1 | Factor: SP1; motif: GGGGYGGGGNS; match class: 1 | 36 | 0.007656 | 3 |
| TF | TF:M01873 | Factor: Egr-1; motif: GCGGGGGCGG | Factor: Egr-1; motif: GCGGGGGCGG | 54 | 0.007742 | 3 |
| TF | TF:M01303 | Factor: SP1; motif: GGGGYGGGGNS | Factor: SP1; motif: GGGGYGGGGNS | 60 | 0.008051 | 3 |
| TF | TF:M02089 | Factor: E2F-3; motif: GGCGGGN | Factor: E2F-3; motif: GGCGGGN | 82 | 0.009800 | 3 |
| TF | TF:M09658 | Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS | Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS | 46 | 0.010066 | 3 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 71 | 0.011619 | 3 |
| TF | TF:M02036 | Factor: WT1; motif: CGCCCCCNCN | Factor: WT1; motif: CGCCCCCNCN | 68 | 0.013146 | 3 |
| TF | TF:M09973_1 | Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 | Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 | 53 | 0.013557 | 3 |
| TF | TF:M09765_1 | Factor: SP1; motif: NRGKGGGCGGGGCN; match class: 1 | Factor: SP1; motif: NRGKGGGCGGGGCN; match class: 1 | 34 | 0.014993 | 3 |
| TF | TF:M00470_1 | Factor: AP-2gamma; motif: GCCYNNGGS; match class: 1 | Factor: AP-2gamma; motif: GCCYNNGGS; match class: 1 | 47 | 0.018190 | 3 |
| TF | TF:M10072 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | 71 | 0.018452 | 3 |
| TF | TF:M00982_1 | Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1 | Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1 | 35 | 0.019314 | 3 |
| TF | TF:M07354 | Factor: Egr-1; motif: GCGGGGGCGG | Factor: Egr-1; motif: GCGGGGGCGG | 59 | 0.019382 | 3 |
| TF | TF:M08952 | Factor: NF-KAPPAB1; motif: NGGKRNTTYCCCN | Factor: NF-KAPPAB1; motif: NGGKRNTTYCCCN | 58 | 0.019600 | 3 |
| TF | TF:M12590_1 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1 | 53 | 0.019813 | 3 |
| TF | TF:M10435_1 | Factor: Sp2; motif: GGGGCGGGG; match class: 1 | Factor: Sp2; motif: GGGGCGGGG; match class: 1 | 35 | 0.019928 | 3 |
| TF | TF:M07615_1 | Factor: Sp3; motif: GGGGCGGGGSNN; match class: 1 | Factor: Sp3; motif: GGGGCGGGGSNN; match class: 1 | 31 | 0.020678 | 3 |
| TF | TF:M12666_1 | Factor: SP1; motif: GGCCCCGCCCCCN; match class: 1 | Factor: SP1; motif: GGCCCCGCCCCCN; match class: 1 | 40 | 0.023952 | 3 |
| TF | TF:M12313 | Factor: ZNF460; motif: NNACNCCCCCCNN | Factor: ZNF460; motif: NNACNCCCCCCNN | 48 | 0.028080 | 3 |
| TF | TF:M07206_1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | 72 | 0.028751 | 3 |
| TF | TF:M13128_1 | Factor: MED8; motif: CYYNSCYYCCTSCNCC; match class: 1 | Factor: MED8; motif: CYYNSCYYCCTSCNCC; match class: 1 | 58 | 0.028859 | 3 |
| TF | TF:M04595_1 | Factor: SALL2; motif: GGGTGGG; match class: 1 | Factor: SALL2; motif: GGGTGGG; match class: 1 | 56 | 0.029153 | 3 |
| TF | TF:M01858 | Factor: AP-2beta; motif: GCNNNGGSCNGVGGGN | Factor: AP-2beta; motif: GCNNNGGSCNGVGGGN | 56 | 0.033368 | 3 |
| TF | TF:M00982 | Factor: KROX; motif: CCCGCCCCCRCCCC | Factor: KROX; motif: CCCGCCCCCRCCCC | 58 | 0.035064 | 3 |
| TF | TF:M00932_1 | Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 | Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 | 49 | 0.035248 | 3 |
| TF | TF:M03876_1 | Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 | Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 | 64 | 0.035979 | 3 |
| TF | TF:M12726 | Factor: PURBETA; motif: NCWGRGGCTGGGG | Factor: PURBETA; motif: NCWGRGGCTGGGG | 57 | 0.039761 | 3 |
| TF | TF:M01104 | Factor: MOVO-B; motif: GNGGGGG | Factor: MOVO-B; motif: GNGGGGG | 69 | 0.042390 | 3 |
| TF | TF:M13366_1 | Factor: ZBED4; motif: CCCGCYCCGC; match class: 1 | Factor: ZBED4; motif: CCCGCYCCGC; match class: 1 | 36 | 0.045000 | 3 |
| TF | TF:M00470 | Factor: AP-2gamma; motif: GCCYNNGGS | Factor: AP-2gamma; motif: GCCYNNGGS | 65 | 0.047180 | 3 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 21 | 0.000022 | 3 |
| MIRNA | MIRNA:hsa-mir-1-3p | hsa-mir-1-3p | hsa-mir-1-3p | 20 | 0.000041 | 3 |
| MIRNA | MIRNA:hsa-mir-4474-3p | hsa-mir-4474-3p | hsa-mir-4474-3p | 18 | 0.000240 | 3 |
| MIRNA | MIRNA:hsa-mir-145-5p | hsa-mir-145-5p | hsa-mir-145-5p | 10 | 0.000659 | 3 |
| MIRNA | MIRNA:hsa-mir-4698 | hsa-mir-4698 | hsa-mir-4698 | 29 | 0.000752 | 3 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 26 | 0.000850 | 3 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 24 | 0.000855 | 3 |
| MIRNA | MIRNA:hsa-mir-320b | hsa-mir-320b | hsa-mir-320b | 23 | 0.000857 | 3 |
| MIRNA | MIRNA:hsa-mir-3591-5p | hsa-mir-3591-5p | hsa-mir-3591-5p | 17 | 0.000878 | 3 |
| MIRNA | MIRNA:hsa-mir-3658 | hsa-mir-3658 | hsa-mir-3658 | 24 | 0.001258 | 3 |
| MIRNA | MIRNA:hsa-mir-4801 | hsa-mir-4801 | hsa-mir-4801 | 23 | 0.003031 | 3 |
| MIRNA | MIRNA:hsa-mir-4731-3p | hsa-mir-4731-3p | hsa-mir-4731-3p | 23 | 0.003066 | 3 |
| MIRNA | MIRNA:hsa-mir-3972 | hsa-mir-3972 | hsa-mir-3972 | 17 | 0.008739 | 3 |
| MIRNA | MIRNA:hsa-mir-1202 | hsa-mir-1202 | hsa-mir-1202 | 17 | 0.009121 | 3 |
| MIRNA | MIRNA:hsa-mir-570 | hsa-mir-570 | hsa-mir-570 | 26 | 0.009192 | 3 |
| MIRNA | MIRNA:hsa-mir-544a | hsa-mir-544a | hsa-mir-544a | 7 | 0.009325 | 3 |
| MIRNA | MIRNA:hsa-mir-34a-5p | hsa-mir-34a-5p | hsa-mir-34a-5p | 13 | 0.010001 | 3 |
| MIRNA | MIRNA:hsa-let-7e-5p | hsa-let-7e-5p | hsa-let-7e-5p | 13 | 0.010390 | 3 |
| MIRNA | MIRNA:hsa-mir-4255 | hsa-mir-4255 | hsa-mir-4255 | 16 | 0.012474 | 3 |
| MIRNA | MIRNA:hsa-mir-621 | hsa-mir-621 | hsa-mir-621 | 10 | 0.013487 | 3 |
| MIRNA | MIRNA:hsa-mir-3688-5p | hsa-mir-3688-5p | hsa-mir-3688-5p | 16 | 0.014641 | 3 |
| MIRNA | MIRNA:hsa-mir-548l | hsa-mir-548l | hsa-mir-548l | 20 | 0.017104 | 3 |
| MIRNA | MIRNA:hsa-mir-338-3p | hsa-mir-338-3p | hsa-mir-338-3p | 20 | 0.020690 | 3 |
| MIRNA | MIRNA:hsa-mir-320d | hsa-mir-320d | hsa-mir-320d | 20 | 0.021867 | 3 |
| MIRNA | MIRNA:hsa-mir-4429 | hsa-mir-4429 | hsa-mir-4429 | 20 | 0.022109 | 3 |
| MIRNA | MIRNA:hsa-mir-33a-5p | hsa-mir-33a-5p | hsa-mir-33a-5p | 7 | 0.023502 | 3 |
| MIRNA | MIRNA:hsa-mir-320c | hsa-mir-320c | hsa-mir-320c | 20 | 0.026907 | 3 |
| MIRNA | MIRNA:hsa-mir-3662 | hsa-mir-3662 | hsa-mir-3662 | 28 | 0.028585 | 3 |
| MIRNA | MIRNA:hsa-mir-4436a | hsa-mir-4436a | hsa-mir-4436a | 19 | 0.028974 | 3 |
| MIRNA | MIRNA:hsa-mir-450b-5p | hsa-mir-450b-5p | hsa-mir-450b-5p | 21 | 0.029484 | 3 |
| MIRNA | MIRNA:hsa-mir-545 | hsa-mir-545 | hsa-mir-545 | 23 | 0.030287 | 3 |
| MIRNA | MIRNA:hsa-mir-222-3p | hsa-mir-222-3p | hsa-mir-222-3p | 10 | 0.036260 | 3 |
| MIRNA | MIRNA:hsa-mir-3678-3p | hsa-mir-3678-3p | hsa-mir-3678-3p | 19 | 0.037411 | 3 |
| MIRNA | MIRNA:hsa-mir-4521 | hsa-mir-4521 | hsa-mir-4521 | 13 | 0.044130 | 3 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011876 | Abnormal platelet volume | Anomalous size of platelets. Most normal sized platelets are 1.5 to 3 micrometers in diameter. Large platelets are 4 to 7 micrometers. Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers. | 6 | 0.000463 | 3 |
| HP | HP:0011877 | Increased mean platelet volume | Average platelet volume above the upper limit of the normal reference interval. | 5 | 0.004545 | 3 |
| HP | HP:0001648 | Cor pulmonale | Right-sided heart failure resulting from chronic hypertension in the pulmonary arteries and right ventricle. | 4 | 0.008662 | 3 |
| HP | HP:0030956 | Abnormality of cardiovascular system electrophysiology | An anomaly of the electrical conduction physiology of the heart. | 16 | 0.015978 | 3 |
| HP | HP:0100308 | Cerebral cortical hemiatrophy | Atrophy of one side of the brain, characterized by findings including thinning of the cerebral cortex, reduced volume of the cerebral white matter with abnormal myelination, and enlargement of the ispilateral fourth ventricle. | 3 | 0.016543 | 3 |
| HP | HP:0011025 | Abnormal cardiovascular system physiology | Abnormal functionality of the cardiovascular system. | 26 | 0.031964 | 3 |
| HP | HP:0008366 | Foot joint contracture | Contractures of one or more joints of the feet meaning chronic loss of joint motion due to structural changes in non-bony tissue. | 8 | 0.045611 | 3 |
Community 4
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-72163 | mRNA Splicing - Major Pathway | mRNA Splicing - Major Pathway | 27 | 6.516459e-33 | 4 |
| REAC | REAC:R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | Processing of Capped Intron-Containing Pre-mRNA | 29 | 1.085771e-32 | 4 |
| REAC | REAC:R-HSA-72172 | mRNA Splicing | mRNA Splicing | 27 | 1.720794e-32 | 4 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 32 | 5.107950e-25 | 4 |
| REAC | REAC:R-HSA-73856 | RNA Polymerase II Transcription Termination | RNA Polymerase II Transcription Termination | 7 | 3.854530e-06 | 4 |
| REAC | REAC:R-HSA-72165 | mRNA Splicing - Minor Pathway | mRNA Splicing - Minor Pathway | 5 | 6.987483e-04 | 4 |
| REAC | REAC:R-HSA-6803529 | FGFR2 alternative splicing | FGFR2 alternative splicing | 4 | 1.418097e-03 | 4 |
| REAC | REAC:R-HSA-72187 | mRNA 3'-end processing | mRNA 3'-end processing | 5 | 1.519556e-03 | 4 |
| REAC | REAC:R-HSA-191859 | snRNP Assembly | snRNP Assembly | 4 | 2.582749e-02 | 4 |
| REAC | REAC:R-HSA-194441 | Metabolism of non-coding RNA | Metabolism of non-coding RNA | 4 | 2.582749e-02 | 4 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 23 | 3.681455e-29 | 4 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 53 | 1.864239e-28 | 4 |
| GO:CC | GO:0071013 | catalytic step 2 spliceosome | "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 16 | 5.307211e-23 | 4 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 53 | 1.434282e-22 | 4 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 54 | 1.155862e-19 | 4 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 54 | 1.155862e-19 | 4 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 54 | 1.155862e-19 | 4 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 57 | 4.295720e-14 | 4 |
| GO:CC | GO:0034709 | methylosome | "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452] | 6 | 1.291583e-10 | 4 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 19 | 2.891281e-10 | 4 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 25 | 2.901806e-10 | 4 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 30 | 3.007448e-10 | 4 |
| GO:CC | GO:0005684 | U2-type spliceosomal complex | "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900] | 9 | 9.335208e-10 | 4 |
| GO:CC | GO:0016607 | nuclear speck | "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640] | 14 | 1.190692e-09 | 4 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 29 | 1.368732e-09 | 4 |
| GO:CC | GO:0035145 | exon-exon junction complex | "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026] | 6 | 4.016493e-09 | 4 |
| GO:CC | GO:0071011 | precatalytic spliceosome | "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] | 7 | 3.897917e-08 | 4 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 59 | 1.747412e-07 | 4 |
| GO:CC | GO:0071005 | U2-type precatalytic spliceosome | "A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] | 6 | 1.106949e-06 | 4 |
| GO:CC | GO:0005689 | U12-type spliceosomal complex | "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955] | 5 | 2.371934e-06 | 4 |
| GO:CC | GO:0071007 | U2-type catalytic step 2 spliceosome | "A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 5 | 4.161048e-06 | 4 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 59 | 8.960367e-06 | 4 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 42 | 2.018505e-05 | 4 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 59 | 3.297625e-05 | 4 |
| GO:CC | GO:0034708 | methyltransferase complex | "A protein complex that possesses methyltransferase activity." [GOC:mah] | 6 | 8.915069e-05 | 4 |
| GO:CC | GO:0034715 | pICln-Sm protein complex | "A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG." [GOC:mah, PMID:11713266] | 3 | 9.394647e-05 | 4 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 59 | 4.846247e-04 | 4 |
| GO:CC | GO:0042382 | paraspeckles | "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299] | 3 | 1.325396e-03 | 4 |
| GO:CC | GO:0034719 | SMN-Sm protein complex | "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408] | 3 | 3.745232e-03 | 4 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 30 | 6.420199e-03 | 4 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 59 | 1.210239e-02 | 4 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 6 | 1.742167e-02 | 4 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 6 | 2.574972e-02 | 4 |
| GO:CC | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex | "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits." [PMID:15571813, PMID:15688063] | 2 | 2.687269e-02 | 4 |
| GO:CC | GO:0005683 | U7 snRNP | "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004] | 2 | 3.755613e-02 | 4 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 10 | 3.802612e-02 | 4 |
| GO:CC | GO:0005686 | U2 snRNP | "A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] | 4 | 4.239421e-02 | 4 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP411 | mRNA processing | mRNA processing | 21 | 2.766730e-27 | 4 |
| WP | WP:WP3594 | Circadian rhythm genes | Circadian rhythm genes | 6 | 3.398955e-02 | 4 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 20 | 1.075190e-23 | 4 |
| KEGG | KEGG:03015 | mRNA surveillance pathway | mRNA surveillance pathway | 8 | 2.765904e-07 | 4 |
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | Nucleocytoplasmic transport | 6 | 3.361047e-04 | 4 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 46 | 2.303500e-23 | 4 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 52 | 2.160152e-19 | 4 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 20 | 3.490405e-17 | 4 |
| GO:MF | GO:0003730 | mRNA 3'-UTR binding | "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] | 9 | 2.790949e-08 | 4 |
| GO:MF | GO:0003727 | single-stranded RNA binding | "Binding to single-stranded RNA." [GOC:jl] | 8 | 8.585043e-08 | 4 |
| GO:MF | GO:0003724 | RNA helicase activity | "Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098] | 7 | 1.516096e-06 | 4 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 26 | 1.780575e-06 | 4 |
| GO:MF | GO:0008186 | ATP-dependent activity, acting on RNA | "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl] | 7 | 1.823737e-06 | 4 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 13 | 1.984903e-05 | 4 |
| GO:MF | GO:0120545 | nucleic acid conformation isomerase activity | "Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-] | 8 | 2.052784e-05 | 4 |
| GO:MF | GO:0004386 | helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] | 7 | 2.555540e-04 | 4 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 8 | 1.254996e-03 | 4 |
| GO:MF | GO:0043021 | ribonucleoprotein complex binding | "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] | 6 | 7.324541e-03 | 4 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 57 | 2.216513e-02 | 4 |
| GO:MF | GO:0033677 | DNA/RNA helicase activity | "Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis." [GOC:mah] | 2 | 3.001294e-02 | 4 |
| GO:MF | GO:0016853 | isomerase activity | "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] | 8 | 3.120124e-02 | 4 |
| GO:MF | GO:0003725 | double-stranded RNA binding | "Binding to double-stranded RNA." [GOC:jl] | 4 | 3.785065e-02 | 4 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0016071 | mRNA metabolic process | "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 39 | 4.256908e-22 | 4 |
| GO:BP | GO:0008380 | RNA splicing | "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] | 37 | 5.643489e-22 | 4 |
| GO:BP | GO:0043484 | regulation of RNA splicing | "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] | 19 | 6.452433e-22 | 4 |
| GO:BP | GO:0006397 | mRNA processing | "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] | 36 | 2.455408e-20 | 4 |
| GO:BP | GO:1903311 | regulation of mRNA metabolic process | "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 20 | 3.511467e-19 | 4 |
| GO:BP | GO:0050684 | regulation of mRNA processing | "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] | 16 | 4.079352e-19 | 4 |
| GO:BP | GO:0000398 | mRNA splicing, via spliceosome | "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] | 33 | 2.921992e-18 | 4 |
| GO:BP | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] | 33 | 2.921992e-18 | 4 |
| GO:BP | GO:0000375 | RNA splicing, via transesterification reactions | "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] | 33 | 3.145521e-18 | 4 |
| GO:BP | GO:0048024 | regulation of mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 14 | 1.159776e-16 | 4 |
| GO:BP | GO:0000380 | alternative mRNA splicing, via spliceosome | "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] | 12 | 1.417602e-15 | 4 |
| GO:BP | GO:0006396 | RNA processing | "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] | 39 | 4.114367e-15 | 4 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 52 | 2.046954e-14 | 4 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 53 | 4.766945e-14 | 4 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 49 | 5.749623e-13 | 4 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 48 | 2.935568e-12 | 4 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 49 | 3.862824e-12 | 4 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 48 | 1.076829e-11 | 4 |
| GO:BP | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] | 8 | 4.854363e-09 | 4 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 52 | 5.722810e-09 | 4 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 51 | 6.767118e-09 | 4 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 33 | 3.728769e-08 | 4 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 34 | 5.647614e-08 | 4 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 39 | 7.239673e-08 | 4 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 39 | 1.736033e-07 | 4 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 39 | 3.254180e-07 | 4 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 52 | 6.320744e-07 | 4 |
| GO:BP | GO:1903312 | negative regulation of mRNA metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 8 | 7.914289e-07 | 4 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 39 | 8.253942e-07 | 4 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 55 | 9.205422e-07 | 4 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 54 | 2.834698e-06 | 4 |
| GO:BP | GO:0051028 | mRNA transport | "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 8 | 5.523724e-06 | 4 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 40 | 5.732059e-06 | 4 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 11 | 1.345663e-05 | 4 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 41 | 1.605799e-05 | 4 |
| GO:BP | GO:0033119 | negative regulation of RNA splicing | "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah] | 5 | 2.243138e-05 | 4 |
| GO:BP | GO:0050658 | RNA transport | "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 8 | 2.845653e-05 | 4 |
| GO:BP | GO:0050657 | nucleic acid transport | "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] | 8 | 2.845653e-05 | 4 |
| GO:BP | GO:0006401 | RNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 10 | 2.965795e-05 | 4 |
| GO:BP | GO:0051236 | establishment of RNA localization | "The directed movement of RNA to a specific location." [GOC:ai] | 8 | 3.291562e-05 | 4 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 24 | 5.645429e-05 | 4 |
| GO:BP | GO:0141188 | nucleic acid catabolic process | "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators] | 10 | 6.632268e-05 | 4 |
| GO:BP | GO:0006402 | mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 9 | 8.301963e-05 | 4 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 24 | 1.205604e-04 | 4 |
| GO:BP | GO:0000956 | nuclear-transcribed mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] | 7 | 1.256658e-04 | 4 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 15 | 1.310700e-04 | 4 |
| GO:BP | GO:0006403 | RNA localization | "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] | 8 | 1.615229e-04 | 4 |
| GO:BP | GO:0045727 | positive regulation of translation | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] | 7 | 2.225876e-04 | 4 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 14 | 2.657341e-04 | 4 |
| GO:BP | GO:0006405 | RNA export from nucleus | "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma] | 6 | 4.083468e-04 | 4 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 11 | 4.383266e-04 | 4 |
| GO:BP | GO:0015931 | nucleobase-containing compound transport | "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 8 | 5.937107e-04 | 4 |
| GO:BP | GO:0048025 | negative regulation of mRNA splicing, via spliceosome | "Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 4 | 7.986063e-04 | 4 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 55 | 8.431792e-04 | 4 |
| GO:BP | GO:0050686 | negative regulation of mRNA processing | "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing." [GOC:ai] | 4 | 9.647489e-04 | 4 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 12 | 1.200627e-03 | 4 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 25 | 1.233286e-03 | 4 |
| GO:BP | GO:1903241 | U2-type prespliceosome assembly | "The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome." [GO_REF:0000079, GOC:TermGenie, PMID:12374752] | 4 | 1.372559e-03 | 4 |
| GO:BP | GO:0010628 | positive regulation of gene expression | "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 15 | 1.464435e-03 | 4 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 26 | 1.732516e-03 | 4 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 11 | 1.915537e-03 | 4 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 16 | 1.934217e-03 | 4 |
| GO:BP | GO:0010608 | post-transcriptional regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] | 14 | 2.360638e-03 | 4 |
| GO:BP | GO:0036261 | 7-methylguanosine cap hypermethylation | "Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation." [GOC:bf, GOC:BHF, GOC:krc, GOC:mah, GOC:rl, PMID:11983179, PMID:18775984] | 3 | 2.401314e-03 | 4 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 19 | 2.527701e-03 | 4 |
| GO:BP | GO:0061013 | regulation of mRNA catabolic process | "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 7 | 2.571200e-03 | 4 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 22 | 3.488789e-03 | 4 |
| GO:BP | GO:0010629 | negative regulation of gene expression | "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 17 | 3.689875e-03 | 4 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 22 | 5.280614e-03 | 4 |
| GO:BP | GO:1903313 | positive regulation of mRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 6 | 6.100515e-03 | 4 |
| GO:BP | GO:0048026 | positive regulation of mRNA splicing, via spliceosome | "Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 4 | 6.248524e-03 | 4 |
| GO:BP | GO:0050685 | positive regulation of mRNA processing | "Any process that activates or increases the frequency, rate or extent of mRNA processing." [GOC:ai] | 4 | 8.671425e-03 | 4 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 33 | 8.992101e-03 | 4 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 23 | 9.523640e-03 | 4 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 34 | 1.021691e-02 | 4 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 17 | 1.226410e-02 | 4 |
| GO:BP | GO:0051168 | nuclear export | "The directed movement of substances out of the nucleus." [GOC:ai] | 6 | 1.535800e-02 | 4 |
| GO:BP | GO:0097167 | circadian regulation of translation | "Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours." [GOC:ans, PMID:17264215] | 2 | 1.625745e-02 | 4 |
| GO:BP | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] | 4 | 1.849800e-02 | 4 |
| GO:BP | GO:0033120 | positive regulation of RNA splicing | "Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah] | 4 | 2.188335e-02 | 4 |
| GO:BP | GO:0036260 | RNA capping | "The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts." [GOC:bf, GOC:krc, GOC:mah, PMID:18775984, PMID:27383794, PMID:29681497, PMID:30353673] | 3 | 2.363908e-02 | 4 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 15 | 2.566539e-02 | 4 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 23 | 2.972448e-02 | 4 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 14 | 4.340580e-02 | 4 |
| GO:BP | GO:0048511 | rhythmic process | "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] | 7 | 4.376416e-02 | 4 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 26 | 1.090321e-13 | 4 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 16 | 1.062774e-12 | 4 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 17 | 1.100885e-12 | 4 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 27 | 1.519761e-12 | 4 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 21 | 2.000848e-12 | 4 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 20 | 3.715230e-12 | 4 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 22 | 3.998313e-12 | 4 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 25 | 6.562265e-12 | 4 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 22 | 7.619612e-12 | 4 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 23 | 1.731149e-11 | 4 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 22 | 1.741108e-11 | 4 |
| HPA | HPA:0471492 | Skin 2; vascular mural cells[≥Medium] | Skin 2; vascular mural cells[≥Medium] | 14 | 1.872881e-11 | 4 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 22 | 2.010287e-11 | 4 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 15 | 2.039104e-11 | 4 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 20 | 2.286513e-11 | 4 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 15 | 3.302583e-11 | 4 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 24 | 3.318384e-11 | 4 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 21 | 3.648790e-11 | 4 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 22 | 4.655031e-11 | 4 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 14 | 5.312194e-11 | 4 |
| HPA | HPA:0090183 | Cerebellum; cells in granular layer[High] | Cerebellum; cells in granular layer[High] | 22 | 6.107288e-11 | 4 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 22 | 6.800340e-11 | 4 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 15 | 9.213340e-11 | 4 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 14 | 1.084660e-10 | 4 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 22 | 1.455272e-10 | 4 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 37 | 1.601795e-10 | 4 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 25 | 2.122624e-10 | 4 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 21 | 2.528909e-10 | 4 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 28 | 2.680212e-10 | 4 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 26 | 2.928200e-10 | 4 |
| HPA | HPA:0461492 | Skin 1; vascular mural cells[≥Medium] | Skin 1; vascular mural cells[≥Medium] | 13 | 3.498502e-10 | 4 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 20 | 3.646623e-10 | 4 |
| HPA | HPA:0570793 | Testis; round or early spermatids[High] | Testis; round or early spermatids[High] | 24 | 4.120093e-10 | 4 |
| HPA | HPA:0570781 | Testis; preleptotene spermatocytes[≥Low] | Testis; preleptotene spermatocytes[≥Low] | 31 | 4.243739e-10 | 4 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 24 | 4.576707e-10 | 4 |
| HPA | HPA:0050093 | Breast; myoepithelial cells[High] | Breast; myoepithelial cells[High] | 22 | 4.795953e-10 | 4 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 25 | 5.535167e-10 | 4 |
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 20 | 5.734105e-10 | 4 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 14 | 6.331252e-10 | 4 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 14 | 6.331252e-10 | 4 |
| HPA | HPA:0270353 | Kidney; cells in glomeruli[High] | Kidney; cells in glomeruli[High] | 22 | 7.182930e-10 | 4 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 35 | 7.403465e-10 | 4 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 22 | 1.066125e-09 | 4 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 21 | 2.020455e-09 | 4 |
| HPA | HPA:0471493 | Skin 2; vascular mural cells[High] | Skin 2; vascular mural cells[High] | 11 | 2.169342e-09 | 4 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 20 | 2.187881e-09 | 4 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 35 | 2.747104e-09 | 4 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 31 | 2.795820e-09 | 4 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 20 | 2.895976e-09 | 4 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 19 | 2.972724e-09 | 4 |
| HPA | HPA:0050012 | Breast; adipocytes[≥Medium] | Breast; adipocytes[≥Medium] | 27 | 3.051490e-09 | 4 |
| HPA | HPA:0570782 | Testis; preleptotene spermatocytes[≥Medium] | Testis; preleptotene spermatocytes[≥Medium] | 27 | 3.100632e-09 | 4 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 19 | 3.227484e-09 | 4 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 37 | 3.359909e-09 | 4 |
| HPA | HPA:0461493 | Skin 1; vascular mural cells[High] | Skin 1; vascular mural cells[High] | 11 | 3.578075e-09 | 4 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 34 | 3.761414e-09 | 4 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 25 | 3.872130e-09 | 4 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 31 | 4.099211e-09 | 4 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 29 | 4.774306e-09 | 4 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 18 | 5.474637e-09 | 4 |
| HPA | HPA:0570783 | Testis; preleptotene spermatocytes[High] | Testis; preleptotene spermatocytes[High] | 20 | 5.787995e-09 | 4 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 18 | 5.969713e-09 | 4 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 27 | 6.091427e-09 | 4 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 20 | 6.222904e-09 | 4 |
| HPA | HPA:0630053 | Cervix; glandular cells[High] | Cervix; glandular cells[High] | 24 | 7.654744e-09 | 4 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 22 | 7.676922e-09 | 4 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 18 | 8.882941e-09 | 4 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 29 | 1.041338e-08 | 4 |
| HPA | HPA:0080123 | Caudate; glial cells[High] | Caudate; glial cells[High] | 19 | 1.054112e-08 | 4 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 29 | 1.130179e-08 | 4 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 22 | 1.246895e-08 | 4 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 45 | 1.384639e-08 | 4 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 21 | 1.398647e-08 | 4 |
| HPA | HPA:0570772 | Testis; peritubular cells[≥Medium] | Testis; peritubular cells[≥Medium] | 17 | 1.435900e-08 | 4 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 25 | 1.833397e-08 | 4 |
| HPA | HPA:0351183 | Pancreas; pancreatic endocrine cells[High] | Pancreas; pancreatic endocrine cells[High] | 20 | 1.900475e-08 | 4 |
| HPA | HPA:0570792 | Testis; round or early spermatids[≥Medium] | Testis; round or early spermatids[≥Medium] | 29 | 2.654450e-08 | 4 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 23 | 2.850198e-08 | 4 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 18 | 3.053741e-08 | 4 |
| HPA | HPA:0010012 | Adipose tissue; adipocytes[≥Medium] | Adipose tissue; adipocytes[≥Medium] | 31 | 3.375471e-08 | 4 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 27 | 3.531688e-08 | 4 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 20 | 4.362382e-08 | 4 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 44 | 7.450123e-08 | 4 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 29 | 8.540385e-08 | 4 |
| HPA | HPA:0170253 | Endometrium 2; cells in endometrial stroma[High] | Endometrium 2; cells in endometrial stroma[High] | 14 | 8.602077e-08 | 4 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 31 | 8.763879e-08 | 4 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 17 | 9.069791e-08 | 4 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 23 | 9.174213e-08 | 4 |
| HPA | HPA:0570802 | Testis; sertoli cells[≥Medium] | Testis; sertoli cells[≥Medium] | 28 | 9.427045e-08 | 4 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 25 | 9.482005e-08 | 4 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 20 | 9.994938e-08 | 4 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 24 | 1.010740e-07 | 4 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 20 | 1.083276e-07 | 4 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 28 | 1.141606e-07 | 4 |
| HPA | HPA:0380203 | Placenta; endothelial cells[High] | Placenta; endothelial cells[High] | 12 | 1.424317e-07 | 4 |
| HPA | HPA:0461393 | Skin 1; cells in basal layer[High] | Skin 1; cells in basal layer[High] | 11 | 1.533285e-07 | 4 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 40 | 1.684947e-07 | 4 |
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 14 | 1.753138e-07 | 4 |
| HPA | HPA:0490693 | Smooth muscle; smooth muscle cells[High] | Smooth muscle; smooth muscle cells[High] | 17 | 1.850028e-07 | 4 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 15 | 1.917280e-07 | 4 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 41 | 2.079672e-07 | 4 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 30 | 2.082835e-07 | 4 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 13 | 2.212149e-07 | 4 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 26 | 2.435501e-07 | 4 |
| HPA | HPA:0570771 | Testis; peritubular cells[≥Low] | Testis; peritubular cells[≥Low] | 18 | 2.444597e-07 | 4 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 13 | 2.580183e-07 | 4 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 37 | 2.742582e-07 | 4 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 19 | 2.988201e-07 | 4 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 14 | 3.008565e-07 | 4 |
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 28 | 3.073174e-07 | 4 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 31 | 3.902482e-07 | 4 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 39 | 4.140958e-07 | 4 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 14 | 4.583818e-07 | 4 |
| HPA | HPA:0130203 | Colon; endothelial cells[High] | Colon; endothelial cells[High] | 19 | 4.630705e-07 | 4 |
| HPA | HPA:0440343 | Skeletal muscle; myocytes[High] | Skeletal muscle; myocytes[High] | 19 | 7.083347e-07 | 4 |
| HPA | HPA:0570762 | Testis; pachytene spermatocytes[≥Medium] | Testis; pachytene spermatocytes[≥Medium] | 27 | 8.692683e-07 | 4 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 39 | 8.890025e-07 | 4 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 17 | 1.126243e-06 | 4 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 41 | 1.176118e-06 | 4 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 39 | 1.187746e-06 | 4 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 20 | 1.330372e-06 | 4 |
| HPA | HPA:0090182 | Cerebellum; cells in granular layer[≥Medium] | Cerebellum; cells in granular layer[≥Medium] | 33 | 1.379931e-06 | 4 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 39 | 1.496374e-06 | 4 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 26 | 1.554280e-06 | 4 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 46 | 1.617305e-06 | 4 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 32 | 1.827696e-06 | 4 |
| HPA | HPA:0010013 | Adipose tissue; adipocytes[High] | Adipose tissue; adipocytes[High] | 14 | 2.148908e-06 | 4 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 42 | 2.472617e-06 | 4 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 15 | 2.750717e-06 | 4 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 42 | 2.819867e-06 | 4 |
| HPA | HPA:0570791 | Testis; round or early spermatids[≥Low] | Testis; round or early spermatids[≥Low] | 29 | 3.155080e-06 | 4 |
| HPA | HPA:0390053 | Prostate; glandular cells[High] | Prostate; glandular cells[High] | 22 | 4.152792e-06 | 4 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 23 | 4.480452e-06 | 4 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 23 | 4.539388e-06 | 4 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 23 | 4.539388e-06 | 4 |
| HPA | HPA:0380202 | Placenta; endothelial cells[≥Medium] | Placenta; endothelial cells[≥Medium] | 12 | 4.956161e-06 | 4 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 23 | 5.103434e-06 | 4 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 43 | 5.547675e-06 | 4 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 43 | 5.704875e-06 | 4 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 34 | 7.079192e-06 | 4 |
| HPA | HPA:0381192 | Placenta; cytotrophoblasts[≥Medium] | Placenta; cytotrophoblasts[≥Medium] | 13 | 7.620910e-06 | 4 |
| HPA | HPA:0570773 | Testis; peritubular cells[High] | Testis; peritubular cells[High] | 10 | 8.540006e-06 | 4 |
| HPA | HPA:0570803 | Testis; sertoli cells[High] | Testis; sertoli cells[High] | 15 | 8.569535e-06 | 4 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 29 | 8.716851e-06 | 4 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 36 | 9.071299e-06 | 4 |
| HPA | HPA:0381203 | Placenta; hofbauer cells[High] | Placenta; hofbauer cells[High] | 11 | 9.079157e-06 | 4 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 12 | 1.004126e-05 | 4 |
| HPA | HPA:0510652 | Soft tissue 2; fibroblasts[≥Medium] | Soft tissue 2; fibroblasts[≥Medium] | 30 | 1.056348e-05 | 4 |
| HPA | HPA:0510653 | Soft tissue 2; fibroblasts[High] | Soft tissue 2; fibroblasts[High] | 14 | 1.065745e-05 | 4 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 28 | 1.066715e-05 | 4 |
| HPA | HPA:0060103 | Bronchus; respiratory epithelial cells[High] | Bronchus; respiratory epithelial cells[High] | 25 | 1.163059e-05 | 4 |
| HPA | HPA:0090163 | Cerebellum; Purkinje cells[High] | Cerebellum; Purkinje cells[High] | 23 | 1.202563e-05 | 4 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 44 | 1.205676e-05 | 4 |
| HPA | HPA:0360053 | Parathyroid gland; glandular cells[High] | Parathyroid gland; glandular cells[High] | 23 | 1.217386e-05 | 4 |
| HPA | HPA:0340000 | Ovary | Ovary | 43 | 1.403067e-05 | 4 |
| HPA | HPA:0381193 | Placenta; cytotrophoblasts[High] | Placenta; cytotrophoblasts[High] | 11 | 1.440326e-05 | 4 |
| HPA | HPA:0270363 | Kidney; cells in tubules[High] | Kidney; cells in tubules[High] | 27 | 1.508237e-05 | 4 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 38 | 1.517391e-05 | 4 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 39 | 1.557261e-05 | 4 |
| HPA | HPA:0500653 | Soft tissue 1; fibroblasts[High] | Soft tissue 1; fibroblasts[High] | 14 | 1.666946e-05 | 4 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 38 | 1.945697e-05 | 4 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 35 | 1.967208e-05 | 4 |
| HPA | HPA:0130242 | Colon; peripheral nerve/ganglion[≥Medium] | Colon; peripheral nerve/ganglion[≥Medium] | 34 | 2.013994e-05 | 4 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 37 | 2.043714e-05 | 4 |
| HPA | HPA:0381202 | Placenta; hofbauer cells[≥Medium] | Placenta; hofbauer cells[≥Medium] | 12 | 2.115193e-05 | 4 |
| HPA | HPA:0570761 | Testis; pachytene spermatocytes[≥Low] | Testis; pachytene spermatocytes[≥Low] | 28 | 2.320029e-05 | 4 |
| HPA | HPA:0050013 | Breast; adipocytes[High] | Breast; adipocytes[High] | 11 | 2.386707e-05 | 4 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 30 | 2.797154e-05 | 4 |
| HPA | HPA:0270352 | Kidney; cells in glomeruli[≥Medium] | Kidney; cells in glomeruli[≥Medium] | 32 | 2.823248e-05 | 4 |
| HPA | HPA:0381191 | Placenta; cytotrophoblasts[≥Low] | Placenta; cytotrophoblasts[≥Low] | 13 | 2.958989e-05 | 4 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 20 | 3.144276e-05 | 4 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 37 | 3.487043e-05 | 4 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 41 | 3.582630e-05 | 4 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 35 | 3.629680e-05 | 4 |
| HPA | HPA:0490692 | Smooth muscle; smooth muscle cells[≥Medium] | Smooth muscle; smooth muscle cells[≥Medium] | 32 | 3.822821e-05 | 4 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 47 | 4.033914e-05 | 4 |
| HPA | HPA:0380201 | Placenta; endothelial cells[≥Low] | Placenta; endothelial cells[≥Low] | 12 | 4.112377e-05 | 4 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 43 | 4.130681e-05 | 4 |
| HPA | HPA:0050000 | Breast | Breast | 48 | 4.245559e-05 | 4 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 39 | 5.346445e-05 | 4 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 31 | 5.740916e-05 | 4 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 40 | 6.041731e-05 | 4 |
| HPA | HPA:0440342 | Skeletal muscle; myocytes[≥Medium] | Skeletal muscle; myocytes[≥Medium] | 35 | 6.625431e-05 | 4 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 37 | 7.826460e-05 | 4 |
| HPA | HPA:0530713 | Spleen; cells in red pulp[High] | Spleen; cells in red pulp[High] | 16 | 8.085967e-05 | 4 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 44 | 9.007365e-05 | 4 |
| HPA | HPA:0620000 | Vagina | Vagina | 44 | 9.007365e-05 | 4 |
| HPA | HPA:0381201 | Placenta; hofbauer cells[≥Low] | Placenta; hofbauer cells[≥Low] | 12 | 9.107336e-05 | 4 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 17 | 9.255478e-05 | 4 |
| HPA | HPA:0080000 | Caudate | Caudate | 47 | 1.037160e-04 | 4 |
| HPA | HPA:0381213 | Placenta; syncytiotrophoblasts - cell body[High] | Placenta; syncytiotrophoblasts - cell body[High] | 11 | 1.103847e-04 | 4 |
| HPA | HPA:0510703 | Soft tissue 2; peripheral nerve[High] | Soft tissue 2; peripheral nerve[High] | 10 | 1.408043e-04 | 4 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 10 | 1.545829e-04 | 4 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 37 | 1.625988e-04 | 4 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 47 | 1.795767e-04 | 4 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 44 | 1.930249e-04 | 4 |
| HPA | HPA:0030073 | Appendix; lymphoid tissue[High] | Appendix; lymphoid tissue[High] | 15 | 1.939799e-04 | 4 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 35 | 1.981310e-04 | 4 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 35 | 1.981310e-04 | 4 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 40 | 2.443352e-04 | 4 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 39 | 2.576940e-04 | 4 |
| HPA | HPA:0500703 | Soft tissue 1; peripheral nerve[High] | Soft tissue 1; peripheral nerve[High] | 9 | 2.616728e-04 | 4 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 33 | 2.871586e-04 | 4 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 46 | 3.189643e-04 | 4 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 46 | 3.382695e-04 | 4 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 44 | 3.492478e-04 | 4 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 45 | 3.678407e-04 | 4 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 43 | 3.798809e-04 | 4 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 35 | 3.803373e-04 | 4 |
| HPA | HPA:0220053 | Gallbladder; glandular cells[High] | Gallbladder; glandular cells[High] | 29 | 3.959663e-04 | 4 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 47 | 4.079743e-04 | 4 |
| HPA | HPA:0241103 | Heart muscle; cardiomyocytes[High] | Heart muscle; cardiomyocytes[High] | 18 | 4.119714e-04 | 4 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 44 | 4.218059e-04 | 4 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 44 | 4.218059e-04 | 4 |
| HPA | HPA:0030053 | Appendix; glandular cells[High] | Appendix; glandular cells[High] | 23 | 4.297142e-04 | 4 |
| HPA | HPA:0030071 | Appendix; lymphoid tissue[≥Low] | Appendix; lymphoid tissue[≥Low] | 38 | 4.706381e-04 | 4 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 40 | 5.405196e-04 | 4 |
| HPA | HPA:0400053 | Rectum; glandular cells[High] | Rectum; glandular cells[High] | 27 | 6.268836e-04 | 4 |
| HPA | HPA:0530723 | Spleen; cells in white pulp[High] | Spleen; cells in white pulp[High] | 15 | 7.189522e-04 | 4 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 38 | 7.391930e-04 | 4 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 45 | 8.459027e-04 | 4 |
| HPA | HPA:0390000 | Prostate | Prostate | 45 | 8.459027e-04 | 4 |
| HPA | HPA:0300413 | Lung; macrophages[High] | Lung; macrophages[High] | 19 | 8.811767e-04 | 4 |
| HPA | HPA:0291162 | Liver; cholangiocytes[≥Medium] | Liver; cholangiocytes[≥Medium] | 23 | 9.092802e-04 | 4 |
| HPA | HPA:0381211 | Placenta; syncytiotrophoblasts - cell body[≥Low] | Placenta; syncytiotrophoblasts - cell body[≥Low] | 12 | 1.068045e-03 | 4 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 46 | 1.093084e-03 | 4 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 35 | 1.107547e-03 | 4 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 45 | 1.122648e-03 | 4 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 41 | 1.203652e-03 | 4 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 43 | 1.246997e-03 | 4 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 11 | 1.335130e-03 | 4 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 39 | 1.424203e-03 | 4 |
| HPA | HPA:0381212 | Placenta; syncytiotrophoblasts - cell body[≥Medium] | Placenta; syncytiotrophoblasts - cell body[≥Medium] | 11 | 1.841828e-03 | 4 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 40 | 1.893929e-03 | 4 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 40 | 1.893929e-03 | 4 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 47 | 1.912205e-03 | 4 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 37 | 2.032922e-03 | 4 |
| HPA | HPA:0600443 | Tonsil; non-germinal center cells[High] | Tonsil; non-germinal center cells[High] | 18 | 2.332566e-03 | 4 |
| HPA | HPA:0090181 | Cerebellum; cells in granular layer[≥Low] | Cerebellum; cells in granular layer[≥Low] | 36 | 2.340917e-03 | 4 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 34 | 2.582088e-03 | 4 |
| HPA | HPA:0130202 | Colon; endothelial cells[≥Medium] | Colon; endothelial cells[≥Medium] | 32 | 2.592095e-03 | 4 |
| HPA | HPA:0130053 | Colon; glandular cells[High] | Colon; glandular cells[High] | 25 | 2.627806e-03 | 4 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 46 | 2.754340e-03 | 4 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 48 | 2.787184e-03 | 4 |
| HPA | HPA:0130241 | Colon; peripheral nerve/ganglion[≥Low] | Colon; peripheral nerve/ganglion[≥Low] | 38 | 2.852790e-03 | 4 |
| HPA | HPA:0530712 | Spleen; cells in red pulp[≥Medium] | Spleen; cells in red pulp[≥Medium] | 29 | 2.924320e-03 | 4 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 17 | 2.947550e-03 | 4 |
| HPA | HPA:0150053 | Duodenum; glandular cells[High] | Duodenum; glandular cells[High] | 26 | 2.958072e-03 | 4 |
| HPA | HPA:0500702 | Soft tissue 1; peripheral nerve[≥Medium] | Soft tissue 1; peripheral nerve[≥Medium] | 18 | 3.094625e-03 | 4 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 44 | 3.122849e-03 | 4 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 45 | 3.252089e-03 | 4 |
| HPA | HPA:0100203 | Cerebral cortex; endothelial cells[High] | Cerebral cortex; endothelial cells[High] | 10 | 3.449247e-03 | 4 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 43 | 3.502493e-03 | 4 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 44 | 3.790717e-03 | 4 |
| HPA | HPA:0130243 | Colon; peripheral nerve/ganglion[High] | Colon; peripheral nerve/ganglion[High] | 14 | 4.011531e-03 | 4 |
| HPA | HPA:0100202 | Cerebral cortex; endothelial cells[≥Medium] | Cerebral cortex; endothelial cells[≥Medium] | 25 | 4.578325e-03 | 4 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 39 | 4.663402e-03 | 4 |
| HPA | HPA:0160253 | Endometrium 1; cells in endometrial stroma[High] | Endometrium 1; cells in endometrial stroma[High] | 10 | 4.771678e-03 | 4 |
| HPA | HPA:0510702 | Soft tissue 2; peripheral nerve[≥Medium] | Soft tissue 2; peripheral nerve[≥Medium] | 19 | 5.017929e-03 | 4 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 36 | 5.022310e-03 | 4 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 44 | 5.216858e-03 | 4 |
| HPA | HPA:0440000 | Skeletal muscle | Skeletal muscle | 41 | 5.669541e-03 | 4 |
| HPA | HPA:0440341 | Skeletal muscle; myocytes[≥Low] | Skeletal muscle; myocytes[≥Low] | 41 | 5.669541e-03 | 4 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 46 | 5.680870e-03 | 4 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 46 | 5.680870e-03 | 4 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 26 | 6.753787e-03 | 4 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 43 | 7.668562e-03 | 4 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 43 | 7.668562e-03 | 4 |
| HPA | HPA:0030052 | Appendix; glandular cells[≥Medium] | Appendix; glandular cells[≥Medium] | 39 | 9.664591e-03 | 4 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 41 | 1.014370e-02 | 4 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 42 | 1.027914e-02 | 4 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 36 | 1.229920e-02 | 4 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 31 | 1.273184e-02 | 4 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 41 | 1.303894e-02 | 4 |
| HPA | HPA:0471453 | Skin 2; hair follicles[High] | Skin 2; hair follicles[High] | 4 | 1.328233e-02 | 4 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 32 | 1.344168e-02 | 4 |
| HPA | HPA:0380000 | Placenta | Placenta | 46 | 1.430362e-02 | 4 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 38 | 1.466721e-02 | 4 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 36 | 1.636619e-02 | 4 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 47 | 1.676355e-02 | 4 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 44 | 1.718600e-02 | 4 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 45 | 1.744662e-02 | 4 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 36 | 1.788648e-02 | 4 |
| HPA | HPA:0471452 | Skin 2; hair follicles[≥Medium] | Skin 2; hair follicles[≥Medium] | 6 | 1.839208e-02 | 4 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 43 | 1.903421e-02 | 4 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 43 | 1.903421e-02 | 4 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 37 | 2.043974e-02 | 4 |
| HPA | HPA:0291163 | Liver; cholangiocytes[High] | Liver; cholangiocytes[High] | 8 | 2.070016e-02 | 4 |
| HPA | HPA:0530000 | Spleen | Spleen | 40 | 2.078923e-02 | 4 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 39 | 2.170890e-02 | 4 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 46 | 2.273884e-02 | 4 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 46 | 2.273884e-02 | 4 |
| HPA | HPA:0480053 | Small intestine; glandular cells[High] | Small intestine; glandular cells[High] | 24 | 2.303979e-02 | 4 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 45 | 2.328473e-02 | 4 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 45 | 2.328473e-02 | 4 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 38 | 2.614371e-02 | 4 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 46 | 2.986761e-02 | 4 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 46 | 2.986761e-02 | 4 |
| HPA | HPA:0090933 | Cerebellum; GLUC cells - nucleus[High] | Cerebellum; GLUC cells - nucleus[High] | 4 | 3.255930e-02 | 4 |
| HPA | HPA:0290401 | Liver; hepatocytes[≥Low] | Liver; hepatocytes[≥Low] | 39 | 3.333714e-02 | 4 |
| HPA | HPA:0570733 | Testis; Leydig cells[High] | Testis; Leydig cells[High] | 19 | 3.463664e-02 | 4 |
| HPA | HPA:0091082 | Cerebellum; white matter cells - nucleus[≥Medium] | Cerebellum; white matter cells - nucleus[≥Medium] | 5 | 3.494366e-02 | 4 |
| HPA | HPA:0500701 | Soft tissue 1; peripheral nerve[≥Low] | Soft tissue 1; peripheral nerve[≥Low] | 25 | 3.512877e-02 | 4 |
| HPA | HPA:0150051 | Duodenum; glandular cells[≥Low] | Duodenum; glandular cells[≥Low] | 44 | 3.835093e-02 | 4 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 45 | 3.887835e-02 | 4 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 43 | 3.911931e-02 | 4 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 43 | 3.911931e-02 | 4 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 45 | 4.001869e-02 | 4 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 33 | 4.090077e-02 | 4 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 45 | 4.138927e-02 | 4 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 44 | 4.179954e-02 | 4 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 44 | 4.179954e-02 | 4 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 45 | 4.490588e-02 | 4 |
| HPA | HPA:0091081 | Cerebellum; white matter cells - nucleus[≥Low] | Cerebellum; white matter cells - nucleus[≥Low] | 5 | 4.632571e-02 | 4 |
| HPA | HPA:0090161 | Cerebellum; Purkinje cells[≥Low] | Cerebellum; Purkinje cells[≥Low] | 38 | 4.651402e-02 | 4 |
| HPA | HPA:0570731 | Testis; Leydig cells[≥Low] | Testis; Leydig cells[≥Low] | 44 | 4.663447e-02 | 4 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1181 | C complex spliceosome | C complex spliceosome | 14 | 7.527947e-12 | 4 |
| CORUM | CORUM:351 | Spliceosome | Spliceosome | 16 | 1.037910e-10 | 4 |
| CORUM | CORUM:1332 | Large Drosha complex | Large Drosha complex | 8 | 5.395038e-09 | 4 |
| CORUM | CORUM:2755 | 17S U2 snRNP | 17S U2 snRNP | 7 | 8.673283e-06 | 4 |
| CORUM | CORUM:3082 | DGCR8 multiprotein complex | DGCR8 multiprotein complex | 4 | 1.101912e-03 | 4 |
| CORUM | CORUM:430 | 18S U11/U12 snRNP | 18S U11/U12 snRNP | 5 | 1.609671e-03 | 4 |
| CORUM | CORUM:1068 | 12S U11 snRNP | 12S U11 snRNP | 4 | 5.085473e-03 | 4 |
| CORUM | CORUM:1745 | SMN complex | SMN complex | 4 | 5.085473e-03 | 4 |
| CORUM | CORUM:6858 | CHTOP-methylosome complex | CHTOP-methylosome complex | 3 | 5.236738e-03 | 4 |
| CORUM | CORUM:835 | 6S methyltransferase and RG-containing Sm proteins complex | 6S methyltransferase and RG-containing Sm proteins complex | 3 | 1.804520e-02 | 4 |
| CORUM | CORUM:1142 | SMN complex | SMN complex | 3 | 2.864835e-02 | 4 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00737_1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | 31 | 8.898504e-08 | 4 |
| TF | TF:M10119 | Factor: REX-1; motif: GGCMGCCATTTT | Factor: REX-1; motif: GGCMGCCATTTT | 24 | 9.728437e-07 | 4 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 35 | 2.733237e-05 | 4 |
| TF | TF:M02044 | Factor: YY1; motif: GCCGCCATTTTG | Factor: YY1; motif: GCCGCCATTTTG | 40 | 5.224950e-05 | 4 |
| TF | TF:M00050 | Factor: E2F; motif: TTTSGCGC | Factor: E2F; motif: TTTSGCGC | 42 | 2.360986e-04 | 4 |
| TF | TF:M08020 | Factor: YY2; motif: NNCCGCCATTW | Factor: YY2; motif: NNCCGCCATTW | 19 | 2.654051e-04 | 4 |
| TF | TF:M00940 | Factor: E2F-1; motif: NTTTCGCGCS | Factor: E2F-1; motif: NTTTCGCGCS | 44 | 4.168485e-04 | 4 |
| TF | TF:M08982_1 | Factor: YY1; motif: NAANATGGCGNNN; match class: 1 | Factor: YY1; motif: NAANATGGCGNNN; match class: 1 | 19 | 5.746729e-04 | 4 |
| TF | TF:M00940_1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | 24 | 7.941693e-04 | 4 |
| TF | TF:M08982 | Factor: YY1; motif: NAANATGGCGNNN | Factor: YY1; motif: NAANATGGCGNNN | 41 | 8.876520e-04 | 4 |
| TF | TF:M10880_1 | Factor: Alx-4; motif: NNCRTTAN; match class: 1 | Factor: Alx-4; motif: NNCRTTAN; match class: 1 | 24 | 1.003290e-03 | 4 |
| TF | TF:M08020_1 | Factor: YY2; motif: NNCCGCCATTW; match class: 1 | Factor: YY2; motif: NNCCGCCATTW; match class: 1 | 6 | 1.098149e-03 | 4 |
| TF | TF:M00737 | Factor: E2F-1:DP-2; motif: TTTSSCGC | Factor: E2F-1:DP-2; motif: TTTSSCGC | 46 | 1.107053e-03 | 4 |
| TF | TF:M08875 | Factor: E2F; motif: NNTTTCGCGCN | Factor: E2F; motif: NNTTTCGCGCN | 38 | 1.366528e-03 | 4 |
| TF | TF:M07370 | Factor: YY1; motif: NNNNAARATGGNNNN | Factor: YY1; motif: NNNNAARATGGNNNN | 36 | 1.775988e-03 | 4 |
| TF | TF:M09632_1 | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN; match class: 1 | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN; match class: 1 | 12 | 2.262942e-03 | 4 |
| TF | TF:M10956_1 | Factor: isx; motif: NTCRTTAA; match class: 1 | Factor: isx; motif: NTCRTTAA; match class: 1 | 26 | 3.970663e-03 | 4 |
| TF | TF:M00425_1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | 34 | 4.425464e-03 | 4 |
| TF | TF:M00738 | Factor: E2F-4:DP-1; motif: TTTSGCGC | Factor: E2F-4:DP-1; motif: TTTSGCGC | 48 | 4.916939e-03 | 4 |
| TF | TF:M00427_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 28 | 4.940801e-03 | 4 |
| TF | TF:M10104 | Factor: YY1; motif: CAARATGGCGGC | Factor: YY1; motif: CAARATGGCGGC | 36 | 5.394956e-03 | 4 |
| TF | TF:M01035 | Factor: YY1; motif: NYNKCCATNTT | Factor: YY1; motif: NYNKCCATNTT | 35 | 9.565202e-03 | 4 |
| TF | TF:M07250_1 | Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 | Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 | 34 | 9.744385e-03 | 4 |
| TF | TF:M12273 | Factor: YY1; motif: GGCSGCCATTTTGN | Factor: YY1; motif: GGCSGCCATTTTGN | 36 | 1.021554e-02 | 4 |
| TF | TF:M02011 | Factor: HES-1; motif: GSCACGMGMC | Factor: HES-1; motif: GSCACGMGMC | 29 | 1.163996e-02 | 4 |
| TF | TF:M00738_1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | 28 | 1.203457e-02 | 4 |
| TF | TF:M00739 | Factor: E2F-4:DP-2; motif: TTTCSCGC | Factor: E2F-4:DP-2; motif: TTTCSCGC | 34 | 1.300029e-02 | 4 |
| TF | TF:M07234 | Factor: YY1; motif: CAARATGGCNGC | Factor: YY1; motif: CAARATGGCNGC | 35 | 1.621685e-02 | 4 |
| TF | TF:M10436_1 | Factor: YY1; motif: CAANATGGCGGC; match class: 1 | Factor: YY1; motif: CAANATGGCGGC; match class: 1 | 20 | 2.107754e-02 | 4 |
| TF | TF:M10436 | Factor: YY1; motif: CAANATGGCGGC | Factor: YY1; motif: CAANATGGCGGC | 42 | 2.149106e-02 | 4 |
| TF | TF:M12275 | Factor: YY1; motif: NGCCGCCATYTTGN | Factor: YY1; motif: NGCCGCCATYTTGN | 38 | 2.295487e-02 | 4 |
| TF | TF:M08874 | Factor: E2F1; motif: NNNNNGCGSSAAAN | Factor: E2F1; motif: NNNNNGCGSSAAAN | 39 | 2.327775e-02 | 4 |
| TF | TF:M03791 | Factor: GABPalpha_GABPbeta; motif: CTTCCKGY | Factor: GABPalpha_GABPbeta; motif: CTTCCKGY | 23 | 2.578664e-02 | 4 |
| TF | TF:M11005_1 | Factor: LHX4; motif: NNCRTTAN; match class: 1 | Factor: LHX4; motif: NNCRTTAN; match class: 1 | 28 | 2.816020e-02 | 4 |
| TF | TF:M00739_1 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 | 14 | 2.961471e-02 | 4 |
| TF | TF:M07250 | Factor: E2F-1; motif: NNNSSCGCSAANN | Factor: E2F-1; motif: NNNSSCGCSAANN | 49 | 3.322345e-02 | 4 |
| TF | TF:M00426_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 34 | 3.464196e-02 | 4 |
| TF | TF:M02044_1 | Factor: YY1; motif: GCCGCCATTTTG; match class: 1 | Factor: YY1; motif: GCCGCCATTTTG; match class: 1 | 14 | 3.783511e-02 | 4 |
| TF | TF:M08874_1 | Factor: E2F1; motif: NNNNNGCGSSAAAN; match class: 1 | Factor: E2F1; motif: NNNNNGCGSSAAAN; match class: 1 | 19 | 3.830244e-02 | 4 |
| TF | TF:M02063_1 | Factor: c-ets-1; motif: ACCGGAWGTN; match class: 1 | Factor: c-ets-1; motif: ACCGGAWGTN; match class: 1 | 20 | 3.848127e-02 | 4 |
| TF | TF:M07370_1 | Factor: YY1; motif: NNNNAARATGGNNNN; match class: 1 | Factor: YY1; motif: NNNNAARATGGNNNN; match class: 1 | 13 | 4.065272e-02 | 4 |
| TF | TF:M09789_1 | Factor: TFDP1; motif: NSGCGGGAANN; match class: 1 | Factor: TFDP1; motif: NSGCGGGAANN; match class: 1 | 6 | 4.243014e-02 | 4 |
| TF | TF:M03925_1 | Factor: YY2; motif: NCCGCCATNTY; match class: 1 | Factor: YY2; motif: NCCGCCATNTY; match class: 1 | 11 | 4.994654e-02 | 4 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 17 | 0.000009 | 4 |
| MIRNA | MIRNA:hsa-mir-548ac | hsa-mir-548ac | hsa-mir-548ac | 23 | 0.000025 | 4 |
| MIRNA | MIRNA:hsa-mir-548z | hsa-mir-548z | hsa-mir-548z | 23 | 0.000025 | 4 |
| MIRNA | MIRNA:hsa-mir-548d-3p | hsa-mir-548d-3p | hsa-mir-548d-3p | 23 | 0.000026 | 4 |
| MIRNA | MIRNA:hsa-mir-877-3p | hsa-mir-877-3p | hsa-mir-877-3p | 11 | 0.003090 | 4 |
| MIRNA | MIRNA:hsa-mir-548am | hsa-mir-548am | hsa-mir-548am | 19 | 0.006676 | 4 |
| MIRNA | MIRNA:hsa-mir-548ae | hsa-mir-548ae | hsa-mir-548ae | 19 | 0.006676 | 4 |
| MIRNA | MIRNA:hsa-mir-548aj | hsa-mir-548aj | hsa-mir-548aj | 19 | 0.006676 | 4 |
| MIRNA | MIRNA:hsa-mir-548x | hsa-mir-548x | hsa-mir-548x | 19 | 0.006676 | 4 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 18 | 0.009396 | 4 |
| MIRNA | MIRNA:hsa-mir-649 | hsa-mir-649 | hsa-mir-649 | 10 | 0.030168 | 4 |
| MIRNA | MIRNA:hsa-mir-149-5p | hsa-mir-149-5p | hsa-mir-149-5p | 8 | 0.034751 | 4 |
| MIRNA | MIRNA:hsa-mir-548aa | hsa-mir-548aa | hsa-mir-548aa | 17 | 0.039538 | 4 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002342 | Intellectual disability, moderate | Moderate mental retardation is defined as an intelligence quotient (IQ) in the range of 35-49. | 6 | 0.015411 | 4 |
washu+biogrid+hippie (Leiden)
Community 0
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0022626 | cytosolic ribosome | "A ribosome located in the cytosol." [GOC:mtg_sensu] | 61 | 2.736149e-121 | 0 |
| GO:CC | GO:0044391 | ribosomal subunit | "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl] | 61 | 1.177358e-104 | 0 |
| GO:CC | GO:0005840 | ribosome | "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] | 61 | 2.701024e-74 | 0 |
| GO:CC | GO:0022627 | cytosolic small ribosomal subunit | "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 30 | 8.019323e-62 | 0 |
| GO:CC | GO:0022625 | cytosolic large ribosomal subunit | "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 31 | 4.977560e-59 | 0 |
| GO:CC | GO:0015935 | small ribosomal subunit | "The smaller of the two subunits of a ribosome." [GOC:mah] | 30 | 8.528015e-51 | 0 |
| GO:CC | GO:0015934 | large ribosomal subunit | "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] | 31 | 1.335211e-46 | 0 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 69 | 1.154050e-40 | 0 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 85 | 1.225506e-39 | 0 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 36 | 3.122516e-35 | 0 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 36 | 7.274043e-35 | 0 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 84 | 1.349158e-31 | 0 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 84 | 1.365585e-31 | 0 |
| GO:CC | GO:0032040 | small-subunit processome | "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] | 21 | 2.843598e-31 | 0 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 56 | 2.987685e-28 | 0 |
| GO:CC | GO:0030684 | preribosome | "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] | 21 | 2.336265e-27 | 0 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 85 | 1.088883e-26 | 0 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 45 | 9.614344e-24 | 0 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 36 | 1.614147e-23 | 0 |
| GO:CC | GO:0005730 | nucleolus | "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] | 47 | 1.272263e-22 | 0 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 67 | 5.525118e-19 | 0 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 44 | 1.513519e-18 | 0 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 44 | 2.638492e-18 | 0 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 44 | 2.687411e-18 | 0 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 44 | 2.687411e-18 | 0 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 91 | 6.290557e-18 | 0 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 56 | 9.235444e-16 | 0 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 68 | 4.990873e-15 | 0 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 68 | 4.990873e-15 | 0 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 68 | 4.990873e-15 | 0 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 46 | 1.326198e-12 | 0 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 78 | 5.608261e-12 | 0 |
| GO:CC | GO:0014069 | postsynaptic density | "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density] | 17 | 3.752492e-11 | 0 |
| GO:CC | GO:0032279 | asymmetric synapse | "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef] | 17 | 7.629604e-11 | 0 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 48 | 8.972447e-11 | 0 |
| GO:CC | GO:0099572 | postsynaptic specialization | "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028] | 17 | 1.919897e-10 | 0 |
| GO:CC | GO:0098984 | neuron to neuron synapse | "A synapse in which pre and post-synaptic cells are neurons." [GOC:dos] | 17 | 3.488611e-10 | 0 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 92 | 1.650945e-09 | 0 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 47 | 3.198113e-09 | 0 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 93 | 3.949083e-09 | 0 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 20 | 1.806834e-08 | 0 |
| GO:CC | GO:0005791 | rough endoplasmic reticulum | "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] | 8 | 5.040448e-08 | 0 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 93 | 8.664895e-07 | 0 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 11 | 3.284943e-06 | 0 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 11 | 6.828564e-06 | 0 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 68 | 9.092617e-06 | 0 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 87 | 2.196454e-05 | 0 |
| GO:CC | GO:0098556 | cytoplasmic side of rough endoplasmic reticulum membrane | "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm." [GOC:ab, GOC:dos] | 3 | 4.104743e-04 | 0 |
| GO:CC | GO:0005783 | endoplasmic reticulum | "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] | 24 | 1.145842e-03 | 0 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 81 | 1.421598e-03 | 0 |
| GO:CC | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex | "A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein." [GOC:bf, GOC:PARL, PMID:12628165] | 2 | 1.508120e-02 | 0 |
| GO:CC | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane | "The side (leaflet) of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos] | 3 | 3.010251e-02 | 0 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-192823 | Viral mRNA Translation | Viral mRNA Translation | 60 | 6.231777e-112 | 0 |
| REAC | REAC:R-HSA-156902 | Peptide chain elongation | Peptide chain elongation | 60 | 6.231777e-112 | 0 |
| REAC | REAC:R-HSA-2408557 | Selenocysteine synthesis | Selenocysteine synthesis | 60 | 4.056559e-110 | 0 |
| REAC | REAC:R-HSA-156842 | Eukaryotic Translation Elongation | Eukaryotic Translation Elongation | 60 | 4.056559e-110 | 0 |
| REAC | REAC:R-HSA-72764 | Eukaryotic Translation Termination | Eukaryotic Translation Termination | 60 | 4.056559e-110 | 0 |
| REAC | REAC:R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Response of EIF2AK4 (GCN2) to amino acid deficiency | 61 | 1.309185e-109 | 0 |
| REAC | REAC:R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 60 | 2.921371e-109 | 0 |
| REAC | REAC:R-HSA-72689 | Formation of a pool of free 40S subunits | Formation of a pool of free 40S subunits | 60 | 7.386009e-107 | 0 |
| REAC | REAC:R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | L13a-mediated translational silencing of Ceruloplasmin expression | 61 | 5.658741e-106 | 0 |
| REAC | REAC:R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | GTP hydrolysis and joining of the 60S ribosomal subunit | 61 | 1.226689e-105 | 0 |
| REAC | REAC:R-HSA-72737 | Cap-dependent Translation Initiation | Cap-dependent Translation Initiation | 61 | 2.102765e-103 | 0 |
| REAC | REAC:R-HSA-72613 | Eukaryotic Translation Initiation | Eukaryotic Translation Initiation | 61 | 2.102765e-103 | 0 |
| REAC | REAC:R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | SRP-dependent cotranslational protein targeting to membrane | 60 | 5.478828e-103 | 0 |
| REAC | REAC:R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 60 | 4.971702e-102 | 0 |
| REAC | REAC:R-HSA-927802 | Nonsense-Mediated Decay (NMD) | Nonsense-Mediated Decay (NMD) | 60 | 4.971702e-102 | 0 |
| REAC | REAC:R-HSA-2408522 | Selenoamino acid metabolism | Selenoamino acid metabolism | 60 | 1.017926e-101 | 0 |
| REAC | REAC:R-HSA-168273 | Influenza Viral RNA Transcription and Replication | Influenza Viral RNA Transcription and Replication | 60 | 3.319994e-97 | 0 |
| REAC | REAC:R-HSA-9711097 | Cellular response to starvation | Cellular response to starvation | 61 | 4.709837e-94 | 0 |
| REAC | REAC:R-HSA-168255 | Influenza Infection | Influenza Infection | 60 | 2.688218e-92 | 0 |
| REAC | REAC:R-HSA-8868773 | rRNA processing in the nucleus and cytosol | rRNA processing in the nucleus and cytosol | 63 | 4.025521e-92 | 0 |
| REAC | REAC:R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Major pathway of rRNA processing in the nucleolus and cytosol | 62 | 1.494022e-91 | 0 |
| REAC | REAC:R-HSA-72312 | rRNA processing | rRNA processing | 63 | 1.836131e-90 | 0 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 60 | 6.377898e-89 | 0 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 60 | 1.493685e-81 | 0 |
| REAC | REAC:R-HSA-72766 | Translation | Translation | 61 | 8.162091e-75 | 0 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 60 | 1.240549e-66 | 0 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 61 | 3.043443e-57 | 0 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 65 | 2.400191e-56 | 0 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 67 | 2.751752e-56 | 0 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 61 | 5.220795e-56 | 0 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 67 | 9.050662e-56 | 0 |
| REAC | REAC:R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | SARS-CoV-1 modulates host translation machinery | 29 | 1.393775e-53 | 0 |
| REAC | REAC:R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Formation of the ternary complex, and subsequently, the 43S complex | 30 | 4.889392e-49 | 0 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 64 | 6.903450e-49 | 0 |
| REAC | REAC:R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | SARS-CoV-2 modulates host translation machinery | 29 | 5.237669e-47 | 0 |
| REAC | REAC:R-HSA-72649 | Translation initiation complex formation | Translation initiation complex formation | 30 | 1.030947e-46 | 0 |
| REAC | REAC:R-HSA-72702 | Ribosomal scanning and start codon recognition | Ribosomal scanning and start codon recognition | 30 | 1.030947e-46 | 0 |
| REAC | REAC:R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 30 | 2.051323e-46 | 0 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 64 | 1.904569e-43 | 0 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 30 | 6.839714e-39 | 0 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 64 | 3.176673e-36 | 0 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 70 | 7.190908e-36 | 0 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 71 | 8.431086e-34 | 0 |
| REAC | REAC:R-HSA-9678108 | SARS-CoV-1 Infection | SARS-CoV-1 Infection | 30 | 3.668741e-33 | 0 |
| REAC | REAC:R-HSA-9705683 | SARS-CoV-2-host interactions | SARS-CoV-2-host interactions | 30 | 2.143479e-28 | 0 |
| REAC | REAC:R-HSA-9694516 | SARS-CoV-2 Infection | SARS-CoV-2 Infection | 30 | 3.837765e-23 | 0 |
| REAC | REAC:R-HSA-1430728 | Metabolism | Metabolism | 62 | 3.954162e-23 | 0 |
| REAC | REAC:R-HSA-9679506 | SARS-CoV Infections | SARS-CoV Infections | 31 | 1.680457e-18 | 0 |
| REAC | REAC:R-HSA-6790901 | rRNA modification in the nucleus and cytosol | rRNA modification in the nucleus and cytosol | 7 | 1.739223e-04 | 0 |
| REAC | REAC:R-HSA-9629569 | Protein hydroxylation | Protein hydroxylation | 4 | 7.294536e-03 | 0 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002181 | cytoplasmic translation | "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] | 62 | 5.619586e-109 | 0 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 68 | 6.503048e-76 | 0 |
| GO:BP | GO:0042254 | ribosome biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] | 37 | 1.337890e-39 | 0 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 83 | 1.394110e-39 | 0 |
| GO:BP | GO:0042274 | ribosomal small subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 23 | 4.886269e-30 | 0 |
| GO:BP | GO:0006364 | rRNA processing | "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] | 22 | 2.429079e-20 | 0 |
| GO:BP | GO:0016072 | rRNA metabolic process | "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] | 23 | 3.629917e-20 | 0 |
| GO:BP | GO:0042255 | ribosome assembly | "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428] | 13 | 2.265505e-15 | 0 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 81 | 1.018412e-14 | 0 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 89 | 6.820905e-14 | 0 |
| GO:BP | GO:0022613 | ribonucleoprotein complex biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] | 38 | 1.860203e-13 | 0 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 81 | 2.474132e-13 | 0 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 21 | 4.929830e-13 | 0 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 89 | 5.162056e-13 | 0 |
| GO:BP | GO:0042273 | ribosomal large subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 11 | 3.008405e-11 | 0 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 81 | 2.956202e-10 | 0 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 89 | 3.860293e-08 | 0 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 50 | 9.081190e-07 | 0 |
| GO:BP | GO:0070925 | organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 22 | 1.771955e-06 | 0 |
| GO:BP | GO:0000027 | ribosomal large subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428] | 6 | 2.006296e-06 | 0 |
| GO:BP | GO:1901798 | positive regulation of signal transduction by p53 class mediator | "Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 6 | 5.536492e-06 | 0 |
| GO:BP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 10 | 1.037117e-05 | 0 |
| GO:BP | GO:0000028 | ribosomal small subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl, PMID:30467428] | 5 | 3.107879e-05 | 0 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 13 | 3.147293e-05 | 0 |
| GO:BP | GO:0051438 | regulation of ubiquitin-protein transferase activity | "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] | 6 | 3.915509e-05 | 0 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 27 | 4.348453e-05 | 0 |
| GO:BP | GO:1903050 | regulation of proteolysis involved in protein catabolic process | "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 10 | 2.346111e-04 | 0 |
| GO:BP | GO:0030490 | maturation of SSU-rRNA | "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators] | 6 | 3.087271e-04 | 0 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 9 | 5.652951e-04 | 0 |
| GO:BP | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 6 | 6.567335e-04 | 0 |
| GO:BP | GO:1901796 | regulation of signal transduction by p53 class mediator | "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 7 | 1.124089e-03 | 0 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 61 | 1.199707e-03 | 0 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 14 | 1.980357e-03 | 0 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 14 | 2.172380e-03 | 0 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 9 | 2.858892e-03 | 0 |
| GO:BP | GO:0016567 | protein ubiquitination | "The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419] | 15 | 3.305742e-03 | 0 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 9 | 3.393642e-03 | 0 |
| GO:BP | GO:1904666 | regulation of ubiquitin protein ligase activity | "Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882] | 4 | 4.114615e-03 | 0 |
| GO:BP | GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator | "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871] | 3 | 4.148441e-03 | 0 |
| GO:BP | GO:0051338 | regulation of transferase activity | "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] | 12 | 4.994607e-03 | 0 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 17 | 6.864250e-03 | 0 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 20 | 7.554950e-03 | 0 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 13 | 9.641841e-03 | 0 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] | 16 | 1.014885e-02 | 0 |
| GO:BP | GO:0032071 | regulation of endodeoxyribonuclease activity | "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] | 3 | 1.154121e-02 | 0 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] | 15 | 1.195178e-02 | 0 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 7 | 2.084123e-02 | 0 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 14 | 2.222823e-02 | 0 |
| GO:BP | GO:1904667 | negative regulation of ubiquitin protein ligase activity | "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:tb, GOC:TermGenie, PMID:26216882] | 3 | 2.457276e-02 | 0 |
| GO:BP | GO:0043687 | post-translational protein modification | "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] | 16 | 2.569667e-02 | 0 |
| GO:BP | GO:0030162 | regulation of proteolysis | "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] | 10 | 3.129759e-02 | 0 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 15 | 3.268894e-02 | 0 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 7 | 3.426362e-02 | 0 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 10 | 3.703865e-02 | 0 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 33 | 3.719900e-02 | 0 |
| GO:BP | GO:0034063 | stress granule assembly | "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519] | 4 | 3.756202e-02 | 0 |
| GO:BP | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] | 4 | 4.226554e-02 | 0 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP477 | Cytoplasmic ribosomal proteins | Cytoplasmic ribosomal proteins | 59 | 5.064480e-107 | 0 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03010 | Ribosome | Ribosome | 60 | 1.487260e-92 | 0 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | Coronavirus disease - COVID-19 | 60 | 1.058016e-79 | 0 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:306 | Ribosome, cytoplasmic | Ribosome, cytoplasmic | 54 | 1.469083e-81 | 0 |
| CORUM | CORUM:3055 | Nop56p-associated pre-rRNA complex | Nop56p-associated pre-rRNA complex | 43 | 1.220585e-49 | 0 |
| CORUM | CORUM:305 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 27 | 4.907164e-41 | 0 |
| CORUM | CORUM:338 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 26 | 3.955618e-40 | 0 |
| CORUM | CORUM:308 | 60S ribosomal subunit, cytoplasmic | 60S ribosomal subunit, cytoplasmic | 27 | 3.499311e-34 | 0 |
| CORUM | CORUM:5380 | TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) | TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) | 12 | 2.074076e-13 | 0 |
| CORUM | CORUM:5266 | TNF-alpha/NF-kappa B signaling complex 6 | TNF-alpha/NF-kappa B signaling complex 6 | 5 | 7.629639e-04 | 0 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003735 | structural constituent of ribosome | "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] | 60 | 5.057692e-74 | 0 |
| GO:MF | GO:0005198 | structural molecule activity | "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] | 60 | 6.368526e-50 | 0 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 74 | 1.546258e-40 | 0 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 75 | 1.779309e-24 | 0 |
| GO:MF | GO:0019843 | rRNA binding | "Binding to a ribosomal RNA." [GOC:jl] | 15 | 5.684714e-19 | 0 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 19 | 7.381396e-12 | 0 |
| GO:MF | GO:0048027 | mRNA 5'-UTR binding | "Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid] | 6 | 5.978471e-07 | 0 |
| GO:MF | GO:0055106 | ubiquitin-protein transferase regulator activity | "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl] | 6 | 4.758958e-06 | 0 |
| GO:MF | GO:1990948 | ubiquitin ligase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a ubiquitin ligase." [GOC:dph, GOC:vw, PMID:21389117] | 4 | 5.105722e-05 | 0 |
| GO:MF | GO:0055105 | ubiquitin-protein transferase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase." [GOC:BHF, GOC:rl] | 4 | 2.399693e-04 | 0 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 88 | 2.586290e-04 | 0 |
| GO:MF | GO:0070180 | large ribosomal subunit rRNA binding | "Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh] | 3 | 5.548156e-04 | 0 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 10 | 1.918266e-03 | 0 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 11 | 3.272037e-02 | 0 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0012133 | Erythroid hypoplasia | Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 18 | 1.458855e-30 | 0 |
| HP | HP:0030270 | Elevated red cell adenosine deaminase activity | Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine. | 17 | 6.286226e-30 | 0 |
| HP | HP:0031640 | Abnormal radial artery morphology | Any structural anomaly of the radial artery. | 17 | 6.286226e-30 | 0 |
| HP | HP:0020118 | Radial artery aplasia | Congenital absence of the radial artery. | 17 | 6.286226e-30 | 0 |
| HP | HP:4000209 | Abnormal erythrocyte adenosine deaminase activity | Activity of adenosine deaminase in red blood cells outside the limits of normal. | 17 | 1.691573e-29 | 0 |
| HP | HP:0005532 | Macrocytic dyserythropoietic anemia | Macrocytic dyserythropoietic anemia | 17 | 4.291339e-29 | 0 |
| HP | HP:0002669 | Osteosarcoma | A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor. | 18 | 1.226270e-28 | 0 |
| HP | HP:0012410 | Pure red cell aplasia | A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction. | 17 | 2.377169e-28 | 0 |
| HP | HP:0040276 | Adenocarcinoma of the colon | Adenocarcinoma of the colon | 17 | 8.856235e-27 | 0 |
| HP | HP:0001227 | Abnormality of the thenar eminence | An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb. | 17 | 8.856235e-27 | 0 |
| HP | HP:0006758 | Malignant genitourinary tract tumor | The presence of a malignant neoplasm of the genital system. | 17 | 1.672371e-26 | 0 |
| HP | HP:0001896 | Reticulocytopenia | A reduced number of reticulocytes in the peripheral blood. | 17 | 3.083464e-26 | 0 |
| HP | HP:0011904 | Persistence of hemoglobin F | Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent. | 17 | 3.083464e-26 | 0 |
| HP | HP:0040275 | Adenocarcinoma of the large intestine | A malignant epithelial tumor with a glandular organization that originates in the large intestine. | 17 | 9.824559e-26 | 0 |
| HP | HP:0001895 | Normochromic anemia | Normochromic anemia | 17 | 9.824559e-26 | 0 |
| HP | HP:0012131 | Abnormal number of erythroid precursors | A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 18 | 2.822093e-25 | 0 |
| HP | HP:0009944 | Partial duplication of thumb phalanx | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 17 | 4.854306e-25 | 0 |
| HP | HP:0040273 | Adenocarcinoma of the intestines | A malignant epithelial tumor with a glandular organization that originates in the intestines. | 17 | 8.001200e-25 | 0 |
| HP | HP:0009999 | Partial duplication of the phalanx of hand | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 17 | 1.299501e-24 | 0 |
| HP | HP:0009777 | Absent thumb | Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues. | 18 | 2.919145e-24 | 0 |
| HP | HP:0004808 | Acute myeloid leukemia | A form of leukemia characterized by overproduction of an early myeloid cell. | 19 | 7.970719e-24 | 0 |
| HP | HP:0030272 | Abnormal erythrocyte enzyme concentration or activity | An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme. | 17 | 1.209907e-23 | 0 |
| HP | HP:0005518 | Increased mean corpuscular volume | Larger than normal size of erythrocytes. | 17 | 4.044147e-23 | 0 |
| HP | HP:0001894 | Thrombocytosis | Increased numbers of platelets in the peripheral blood. | 18 | 4.330480e-23 | 0 |
| HP | HP:0000912 | Sprengel anomaly | A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other). | 17 | 8.630830e-23 | 0 |
| HP | HP:0001972 | Macrocytic anemia | A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH). | 18 | 4.477935e-22 | 0 |
| HP | HP:0009942 | Duplication of thumb phalanx | Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits. | 17 | 6.945025e-22 | 0 |
| HP | HP:0000185 | Cleft soft palate | Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency. | 17 | 6.945025e-22 | 0 |
| HP | HP:0025065 | Abnormal mean corpuscular volume | A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters. | 17 | 1.317608e-21 | 0 |
| HP | HP:0001790 | Nonimmune hydrops fetalis | A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens . | 17 | 4.421604e-21 | 0 |
| HP | HP:0001199 | Triphalangeal thumb | A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb. | 17 | 1.365828e-20 | 0 |
| HP | HP:0002863 | Myelodysplasia | Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia. | 19 | 3.140361e-20 | 0 |
| HP | HP:0009380 | Finger aplasia | A developmental defect resulting in the presence of fewer than the normal number of fingers (i.e., aplasia of one or more fingers). | 18 | 3.415141e-20 | 0 |
| HP | HP:0001087 | Developmental glaucoma | Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma. | 17 | 5.058016e-20 | 0 |
| HP | HP:0002672 | Gastrointestinal carcinoma | Gastrointestinal carcinoma | 17 | 5.058016e-20 | 0 |
| HP | HP:0006749 | Malignant gastrointestinal tract tumors | Malignant gastrointestinal tract tumors | 17 | 5.058016e-20 | 0 |
| HP | HP:0011902 | Abnormal hemoglobin | Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes. | 17 | 8.304803e-20 | 0 |
| HP | HP:0002488 | Acute leukemia | A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts). | 19 | 8.975327e-20 | 0 |
| HP | HP:0100273 | Neoplasm of the colon | Neoplasm of the colon | 17 | 2.697119e-19 | 0 |
| HP | HP:0004312 | Abnormal reticulocyte morphology | A reticulocyte abnormality. | 17 | 4.223604e-19 | 0 |
| HP | HP:0010622 | Neoplasm of the skeletal system | A tumor (abnormal growth of tissue) of the skeleton. | 18 | 4.467926e-19 | 0 |
| HP | HP:0001909 | Leukemia | A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. | 20 | 3.387267e-18 | 0 |
| HP | HP:0009778 | Short thumb | Hypoplasia (congenital reduction in size) of the thumb. | 18 | 1.456845e-17 | 0 |
| HP | HP:0001882 | Decreased total leukocyte count | An abnormal decreased number of leukocytes in the blood. | 19 | 2.908456e-17 | 0 |
| HP | HP:0100834 | Neoplasm of the large intestine | The presence of a neoplasm of the large intestine. | 17 | 1.297396e-16 | 0 |
| HP | HP:0000519 | Developmental cataract | A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens. | 18 | 1.381997e-16 | 0 |
| HP | HP:0001875 | Decreased total neutrophil count | Abnormal decrease of absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group. | 20 | 1.847571e-16 | 0 |
| HP | HP:0004377 | Hematological neoplasm | Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). | 22 | 2.584299e-16 | 0 |
| HP | HP:0009601 | Aplasia/Hypoplasia of the thumb | Hypoplastic/small or absent thumb. | 18 | 3.393755e-16 | 0 |
| HP | HP:0000294 | Low anterior hairline | Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella. | 18 | 3.843976e-16 | 0 |
| HP | HP:0000085 | Horseshoe kidney | A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline. | 18 | 4.349993e-16 | 0 |
| HP | HP:0000465 | Webbed neck | Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline. | 17 | 4.978577e-16 | 0 |
| HP | HP:0001789 | Hydrops fetalis | The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema. | 17 | 7.611659e-16 | 0 |
| HP | HP:0001421 | Abnormality of the musculature of the hand | Abnormality of the musculature of the hand | 17 | 8.747354e-16 | 0 |
| HP | HP:0001874 | Abnormality of neutrophils | A neutrophil abnormality. | 21 | 9.422208e-16 | 0 |
| HP | HP:0011991 | Abnormal total neutrophil count | A deviation from the normal range of neutrophil cell counts in the circulation. | 20 | 1.079381e-15 | 0 |
| HP | HP:0100242 | Sarcoma | A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant. | 18 | 3.136360e-15 | 0 |
| HP | HP:0001680 | Coarctation of aorta | Coarctation of the aorta is a narrowing or constriction of a segment of the aorta. | 17 | 2.254089e-14 | 0 |
| HP | HP:0000980 | Pallor | Abnormally pale skin. | 17 | 2.523056e-14 | 0 |
| HP | HP:0001911 | Abnormal granulocyte morphology | Any structural abnormality or abnormal count of granulocytes. | 21 | 3.215385e-14 | 0 |
| HP | HP:0032309 | Abnormal granulocyte count | Abnormal increase or decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group. | 20 | 3.462572e-14 | 0 |
| HP | HP:0010972 | Anemia of inadequate production | A kind of anemia characterized by inadequate production of erythrocytes. | 18 | 8.331424e-14 | 0 |
| HP | HP:0100542 | Abnormal localization of kidney | An abnormal site of the kidney. | 19 | 9.746111e-14 | 0 |
| HP | HP:0010974 | Abnormal myeloid leukocyte morphology | An abnormality of myeloid leukocytes. | 21 | 1.761238e-13 | 0 |
| HP | HP:0000599 | Abnormality of the frontal hairline | An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not. | 18 | 3.617124e-13 | 0 |
| HP | HP:0000782 | Abnormal scapula morphology | Any abnormality of the scapula, also known as the shoulder blade. | 17 | 4.050673e-13 | 0 |
| HP | HP:0410030 | Cleft lip | A gap in the lip or lips. | 18 | 5.018333e-13 | 0 |
| HP | HP:0001518 | Small for gestational age | Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age. | 19 | 7.717843e-13 | 0 |
| HP | HP:0100736 | Abnormal soft palate morphology | An abnormality of the soft palate. | 19 | 8.866993e-13 | 0 |
| HP | HP:0008551 | Microtia | Underdevelopment of the external ear. | 17 | 1.012386e-12 | 0 |
| HP | HP:0009602 | Abnormality of thumb phalanx | A structural anomaly of one or more phalanges of the thumb. | 17 | 2.616522e-12 | 0 |
| HP | HP:0000104 | Renal agenesis | Agenesis, that is, failure of the kidney to develop during embryogenesis and development. | 17 | 3.955555e-12 | 0 |
| HP | HP:0008772 | Aplasia/Hypoplasia of the external ear | The presence of aplasia or developmental hypoplasia of all or part of the external ear. | 17 | 4.290826e-12 | 0 |
| HP | HP:0008771 | Aplasia/Hypoplasia of the ear | The presence of aplasia or developmental hypoplasia of the ear. | 17 | 7.496200e-12 | 0 |
| HP | HP:0034058 | Abnormal fetal morphology | Any structural anomaly of the fetus. | 19 | 1.152172e-11 | 0 |
| HP | HP:0009997 | Duplication of phalanx of hand | This term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated. | 17 | 2.161710e-11 | 0 |
| HP | HP:0004275 | Duplication of hand bones | Duplication of hand bones | 17 | 2.500401e-11 | 0 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 17 | 2.500401e-11 | 0 |
| HP | HP:0009142 | Duplication of bones involving the upper extremities | Duplication of bones involving the upper extremities | 17 | 2.500401e-11 | 0 |
| HP | HP:0011893 | Abnormal leukocyte count | Number of leukocytes per volume of blood beyond normal limits. | 22 | 3.624740e-11 | 0 |
| HP | HP:0001254 | Lethargy | A state of fatigue, either physical or mental slowness and sluggishness, with difficulties in initiating or performing simple tasks. Distinguished from apathy which implies indifference and a lack of desire or interest in the task. A person with lethargy may have the desire, but not the energy to engage in personal or socially relevant tasks. | 17 | 7.144479e-11 | 0 |
| HP | HP:0009553 | Abnormality of the hairline | The hairline refers to the outline of hair of the head. An abnormality of the hairline can refer to an unusually low or high border between areas of the scalp with and without hair or to abnormal projections of scalp hair. | 18 | 8.843149e-11 | 0 |
| HP | HP:0034930 | Digestive system neoplasm | A tumor (abnormal growth of tissue) of the digestive system. | 19 | 1.617309e-10 | 0 |
| HP | HP:0009381 | Short finger | Abnormally short finger associated with developmental hypoplasia. | 18 | 4.266201e-10 | 0 |
| HP | HP:0011361 | Congenital abnormal hair pattern | A congenital abnormality of the distribution of hair growth. | 18 | 4.746453e-10 | 0 |
| HP | HP:0007700 | Ocular anterior segment dysgenesis | Abnormal development (dysgenesis) of the anterior segment of the eye globe. These structures are mainly of mesenchymal origin. | 18 | 5.005146e-10 | 0 |
| HP | HP:0001446 | Abnormality of the musculature of the upper limbs | Abnormality of the musculature of the upper limbs | 17 | 7.686231e-10 | 0 |
| HP | HP:0007378 | Neoplasm of the gastrointestinal tract | A tumor (abnormal growth of tissue) of the gastrointestinal tract. | 17 | 1.601304e-09 | 0 |
| HP | HP:0011792 | Neoplasm by histology | Neoplasm categorized according to type of histological abnormality. | 18 | 2.066176e-09 | 0 |
| HP | HP:0001903 | Anemia | A reduction in erythrocytes volume or hemoglobin concentration. | 22 | 3.898569e-09 | 0 |
| HP | HP:0010987 | Abnormal cellular immune system morphology | An abnormality of the morphology or counts of the cells that make up the immune system. | 22 | 4.158623e-09 | 0 |
| HP | HP:0001881 | Abnormal leukocyte morphology | An abnormality of leukocytes. | 22 | 4.158623e-09 | 0 |
| HP | HP:0006265 | Aplasia/Hypoplasia of fingers | Small/hypoplastic or absent/aplastic fingers. | 18 | 4.202211e-09 | 0 |
| HP | HP:0100037 | Abnormality of the scalp hair | An abnormality of the hair of head. | 19 | 5.034286e-09 | 0 |
| HP | HP:0000501 | Glaucoma | Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure. | 18 | 5.286899e-09 | 0 |
| HP | HP:0010720 | Abnormal hair pattern | An abnormality of the distribution of hair growth. | 18 | 5.286899e-09 | 0 |
| HP | HP:0032251 | Abnormal immune system morphology | Abnormal immune system morphology | 22 | 9.732438e-09 | 0 |
| HP | HP:0001965 | Abnormal scalp morphology | Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows. | 19 | 1.001931e-08 | 0 |
| HP | HP:0011873 | Abnormal platelet count | Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood. | 19 | 1.220049e-08 | 0 |
| HP | HP:0001172 | Abnormal thumb morphology | An abnormal structure of the first digit of the hand. | 18 | 1.338411e-08 | 0 |
| HP | HP:0100627 | Displacement of the urethral meatus | A displacement of the external urethral orifice from its normal position (in males normally placed at the tip of glans penis, in females normally placed about 2.5 cm behind the glans clitoridis and immediately in front of that of the vagina). | 18 | 1.397028e-08 | 0 |
| HP | HP:0011875 | Abnormal platelet morphology | An anomaly in platelet form, ultrastructure, or intracellular organelles. | 19 | 1.425814e-08 | 0 |
| HP | HP:0032076 | Abnormal male urethral meatus morphology | Abnormal male urethral meatus morphology | 18 | 1.521531e-08 | 0 |
| HP | HP:0001877 | Abnormal erythrocyte morphology | Any structural abnormality of erythrocytes (red-blood cells). | 22 | 2.691800e-08 | 0 |
| HP | HP:0008678 | Renal hypoplasia/aplasia | Absence or underdevelopment of the kidney. | 17 | 3.165870e-08 | 0 |
| HP | HP:0001872 | Abnormality of thrombocytes | An abnormality of platelets. | 19 | 3.790021e-08 | 0 |
| HP | HP:0001873 | Thrombocytopenia | A reduction in the number of circulating thrombocytes. | 18 | 4.090252e-08 | 0 |
| HP | HP:0034057 | Fetal anomaly | Structural or functional abnormalities of the fetus. Note that this section comprises terms that describe abnormalities that are specific to the fetus or differ from the corresponding general terms. A term from anywhere in the Human Phenotype Ontology can be applied to a fetus if appropriate. | 20 | 7.334912e-08 | 0 |
| HP | HP:0000047 | Hypospadias | Abnormal position of urethral meatus on the ventral penile shaft (underside) characterized by displacement of the urethral meatus from the tip of the glans penis to the ventral surface of the penis, scrotum, or perineum. | 17 | 7.908295e-08 | 0 |
| HP | HP:0002250 | Abnormal large intestine morphology | Any abnormality of the large intestine. | 18 | 8.569392e-08 | 0 |
| HP | HP:0011793 | Neoplasm by anatomical site | Neoplasm categorized according to the anatomical site of origin of the neoplasm. | 24 | 1.272257e-07 | 0 |
| HP | HP:0000795 | Abnormality of the urethra | An abnormality of the urethra, i.e., of the tube which connects the urinary bladder to the outside of the body. | 18 | 2.003199e-07 | 0 |
| HP | HP:0000470 | Short neck | Diminished length of the neck. | 17 | 2.024350e-07 | 0 |
| HP | HP:0000175 | Cleft palate | Cleft palate is a developmental defect of the palate resulting from a failure of fusion of the palatine processes and manifesting as a separation of the roof of the mouth (soft and hard palate). | 20 | 2.240448e-07 | 0 |
| HP | HP:0002664 | Neoplasm | An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor). | 24 | 2.261430e-07 | 0 |
| HP | HP:0001679 | Abnormal aortic morphology | An abnormality of the aorta. | 17 | 2.463586e-07 | 0 |
| HP | HP:0005280 | Depressed nasal bridge | Posterior positioning of the nasal root in relation to the overall facial profile for age. | 20 | 2.842602e-07 | 0 |
| HP | HP:0000286 | Epicanthus | A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus. | 20 | 2.927737e-07 | 0 |
| HP | HP:0009127 | Abnormality of the musculature of the limbs | Abnormality of the musculature of the limbs | 20 | 6.734383e-07 | 0 |
| HP | HP:0000202 | Orofacial cleft | The presence of a cleft (gap, opening, or groove) in the oral cavity, including cleft of the upper lip and/or cleft of the palate. Cleft of the upper lip is visible as a groove or fissure in the lip, most frequently due to a congenital failure of the maxillary and median nasal processes to fuse. Cleft palate is characterized by a grooved depression or fissure in the roof of the mouth, most often resulting from a congenital failure of the palate to fuse properly. Clefts of the lip and palate can occur individually or together. It is preferable to code each defect separately. | 20 | 7.529171e-07 | 0 |
| HP | HP:5201015 | Craniofacial cleft | Congenital abnormality with cleft (gap or opening) in the craniofacial bones. Craniofacial cleft includes facial cleft, orofacial clef, and cleft of the jaw. | 20 | 8.646371e-07 | 0 |
| HP | HP:0003319 | Abnormality of the cervical spine | Any abnormality of the cervical vertebral column. | 17 | 9.392950e-07 | 0 |
| HP | HP:0000745 | Abnormal diminished volition | A reduction in willful and motivated goal-directed behavior that is considered the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action. | 20 | 9.650020e-07 | 0 |
| HP | HP:0000431 | Wide nasal bridge | Increased breadth of the nasal bridge (and with it, the nasal root). | 18 | 1.021541e-06 | 0 |
| HP | HP:0010936 | Abnormality of the lower urinary tract | An abnormality of the lower urinary tract. | 22 | 2.110841e-06 | 0 |
| HP | HP:0005927 | Aplasia/hypoplasia involving bones of the hand | Absence (due to failure to form) or underdevelopment of the bones of the hand. | 18 | 2.164694e-06 | 0 |
| HP | HP:0001631 | Atrial septal defect | Atrial septal defect (ASD) is a congenital abnormality of the interatrial septum that enables blood flow between the left and right atria via the interatrial septum. | 18 | 2.444186e-06 | 0 |
| HP | HP:0011994 | Abnormal atrial septum morphology | An abnormality of the interatrial septum. | 18 | 2.756943e-06 | 0 |
| HP | HP:0006496 | Aplasia/hypoplasia involving bones of the upper limbs | Absence (due to failure to form) or underdevelopment of the bones of the upper limbs. | 18 | 6.057156e-06 | 0 |
| HP | HP:0001629 | Ventricular septal defect | A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum. | 17 | 9.469927e-06 | 0 |
| HP | HP:0002242 | Abnormal intestine morphology | An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine. | 20 | 9.721097e-06 | 0 |
| HP | HP:0010438 | Abnormal ventricular septum morphology | A structural abnormality of the interventricular septum. | 17 | 1.310772e-05 | 0 |
| HP | HP:0000036 | Abnormal penis morphology | Abnormality of the male external sex organ. | 19 | 1.346932e-05 | 0 |
| HP | HP:0000369 | Low-set ears | Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear. | 20 | 1.443639e-05 | 0 |
| HP | HP:0001671 | Abnormal cardiac septum morphology | An anomaly of the intra-atrial or intraventricular septum. | 20 | 1.772501e-05 | 0 |
| HP | HP:0011927 | Short digit | One or more digit that appears disproportionately short compared to the hand/foot, whereby either the entire digit or a specific phalanx is shortened. | 18 | 1.802443e-05 | 0 |
| HP | HP:0005120 | Abnormal cardiac atrium morphology | Any structural abnormality of a cardiac atrium. | 18 | 1.899286e-05 | 0 |
| HP | HP:0000218 | High palate | Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective). | 20 | 2.425729e-05 | 0 |
| HP | HP:0011004 | Abnormal systemic arterial morphology | An abnormality of the systemic arterial tree, which consists of the aorta and other systemic arteries. | 17 | 2.523249e-05 | 0 |
| HP | HP:0000549 | Abnormal conjugate eye movement | Any deviation from the normal motor coordination of the eyes that allows for bilateral fixation on a single object. | 24 | 2.904587e-05 | 0 |
| HP | HP:0000032 | Abnormal male external genitalia morphology | Any structural abnormality of male external genitalia. | 23 | 3.167295e-05 | 0 |
| HP | HP:0034684 | Abnormal enzyme concentration or activity | Concentration or activity of an enzyme is above or below the limits of normal. | 19 | 4.126741e-05 | 0 |
| HP | HP:0000316 | Hypertelorism | Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes). | 20 | 6.111235e-05 | 0 |
| HP | HP:0000811 | Abnormal external genitalia morphology | A structural anomaly of the external genitalia. | 23 | 7.044370e-05 | 0 |
| HP | HP:0025668 | Abnormal neck morphology | Any structural anomaly of the neck region. | 18 | 7.097514e-05 | 0 |
| HP | HP:0000347 | Micrognathia | Developmental hypoplasia of the mandible. | 20 | 7.514936e-05 | 0 |
| HP | HP:0010461 | Abnormality of the male genitalia | Abnormality of the male genital system. | 23 | 7.680536e-05 | 0 |
| HP | HP:0009118 | Aplasia/Hypoplasia of the mandible | Absence or underdevelopment of the mandible. | 20 | 7.829458e-05 | 0 |
| HP | HP:0000508 | Ptosis | The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective). | 19 | 8.072018e-05 | 0 |
| HP | HP:0000969 | Edema | An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body. | 18 | 8.976486e-05 | 0 |
| HP | HP:0009116 | Aplasia/Hypoplasia involving bones of the skull | Aplasia/Hypoplasia involving bones of the skull | 20 | 9.402433e-05 | 0 |
| HP | HP:0005918 | Abnormal finger phalanx morphology | Abnormalities affecting the phalanx of finger. | 18 | 9.403546e-05 | 0 |
| HP | HP:0004322 | Short stature | A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to \"short stature\" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms). | 25 | 9.665916e-05 | 0 |
| HP | HP:0045060 | Aplasia/hypoplasia involving bones of the extremities | Aplasia/hypoplasia involving bones of the extremities | 18 | 9.849322e-05 | 0 |
| HP | HP:0000486 | Strabismus | A misalignment of the eyes so that the visual axes deviate from bifoveal fixation. The classification of strabismus may be based on a number of features including the relative position of the eyes, whether the deviation is latent or manifest, intermittent or constant, concomitant or otherwise and according to the age of onset and the relevance of any associated refractive error. | 23 | 1.027036e-04 | 0 |
| HP | HP:0012718 | Abnormal gastrointestinal tract morphology | Abnormal structure of the gastrointestinal tract. | 21 | 1.053079e-04 | 0 |
| HP | HP:0025780 | Abnormal volitional state | An abnormality of internal states of motivation or drive that compromise, or interfere with, the ability of the person to attend to basic personal, social, or vocational activities. | 23 | 1.460160e-04 | 0 |
| HP | HP:0000290 | Abnormal forehead morphology | An anomaly of the forehead. | 23 | 2.128142e-04 | 0 |
| HP | HP:0000464 | Abnormality of the neck | An abnormality of the neck. | 18 | 2.159748e-04 | 0 |
| HP | HP:0001713 | Abnormal cardiac ventricle morphology | An abnormality of a cardiac ventricle. | 18 | 2.207245e-04 | 0 |
| HP | HP:0009815 | Aplasia/hypoplasia of the extremities | Absence (due to failure to form) or underdevelopment of the extremities. | 18 | 2.567684e-04 | 0 |
| HP | HP:0000518 | Cataract | A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule. | 19 | 2.710378e-04 | 0 |
| HP | HP:0000159 | Abnormal lip morphology | An abnormality of the lip. | 23 | 3.326953e-04 | 0 |
| HP | HP:0000517 | Abnormal lens morphology | An abnormality of the lens. | 19 | 3.717262e-04 | 0 |
| HP | HP:0011024 | Abnormality of the gastrointestinal tract | An abnormality of the gastrointestinal tract. | 27 | 4.378867e-04 | 0 |
| HP | HP:0025033 | Abnormal digestive system morphology | A structural anomaly of the digestive system. | 21 | 4.585417e-04 | 0 |
| HP | HP:0012243 | Abnormal reproductive system morphology | A structural or developmental anomaly of any of the tissues involved in the genital system. | 24 | 5.499165e-04 | 0 |
| HP | HP:0000002 | Abnormality of body height | Deviation from the norm of height with respect to that which is expected according to age and gender norms. | 25 | 5.783485e-04 | 0 |
| HP | HP:0000357 | Abnormal location of ears | Abnormal location of the ear. | 20 | 6.002526e-04 | 0 |
| HP | HP:0011032 | Abnormality of fluid regulation | An abnormality of the regulation of body fluids. | 18 | 6.264500e-04 | 0 |
| HP | HP:0009122 | Aplasia/hypoplasia affecting bones of the axial skeleton | Absence (due to failure to form) or underdevelopment of bones of the axial skeleton. | 20 | 6.441930e-04 | 0 |
| HP | HP:0004325 | Decreased body weight | Abnormally low body weight. | 25 | 1.395173e-03 | 0 |
| HP | HP:0025766 | Abnormal affect | An anomaly in intensity, frequency, or duration of the verbal or behavioral expression of emotions, feelings, or thoughts. | 23 | 1.425415e-03 | 0 |
| HP | HP:0001595 | Abnormal hair morphology | An abnormality of the hair. | 23 | 1.666875e-03 | 0 |
| HP | HP:0000252 | Microcephaly | Head circumference below 2 standard deviations below the mean for age and gender. | 23 | 1.690620e-03 | 0 |
| HP | HP:0100886 | Abnormality of globe location | An abnormality in the placement of the ocular globe (eyeball). | 21 | 1.851607e-03 | 0 |
| HP | HP:0030669 | Abnormal ocular adnexa morphology | A structural anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. | 25 | 1.933619e-03 | 0 |
| HP | HP:0040195 | Decreased head circumference | An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean. | 23 | 2.029425e-03 | 0 |
| HP | HP:0000422 | Abnormal nasal bridge morphology | Abnormality of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi. | 20 | 2.271280e-03 | 0 |
| HP | HP:0030962 | Abnormal morphology of the great vessels | A structural anomaly affecting a blood vessel involved in the circulation of the heart, i.e., the superior or inferior vena cava, the pulmonary arteries, the pulmonary veins, and the aorta. | 17 | 2.326902e-03 | 0 |
| HP | HP:0001197 | Abnormality of prenatal development or birth | An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities. | 20 | 2.345162e-03 | 0 |
| HP | HP:0001871 | Abnormality of blood and blood-forming tissues | An abnormality of the hematopoietic system. | 24 | 2.460999e-03 | 0 |
| HP | HP:0032039 | Abnormality of the ocular adnexa | An anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. | 25 | 2.563012e-03 | 0 |
| HP | HP:0002977 | Aplasia/Hypoplasia involving the central nervous system | Absence or underdevelopment of tissue in the central nervous system. | 27 | 2.664953e-03 | 0 |
| HP | HP:0000492 | Abnormal eyelid morphology | An abnormality of the eyelids. | 23 | 3.067220e-03 | 0 |
| HP | HP:0000174 | Abnormal palate morphology | Any abnormality of the palate, i.e., of roof of the mouth. | 21 | 3.192375e-03 | 0 |
| HP | HP:0002060 | Abnormal cerebral morphology | Any structural abnormality of the telencephalon, which is also known as the cerebrum. | 28 | 3.538849e-03 | 0 |
| HP | HP:0000315 | Abnormality of the orbital region | Abnormality of the orbital region | 25 | 3.597614e-03 | 0 |
| HP | HP:0005922 | Abnormal hand morphology | Any structural anomaly of the hand. | 20 | 4.055479e-03 | 0 |
| HP | HP:0030791 | Abnormal jaw morphology | A structural anomaly of the jaw, the bony structure of the mouth that consists of the mandible and the maxilla. | 21 | 4.280537e-03 | 0 |
| HP | HP:0000377 | Abnormal pinna morphology | An abnormality of the pinna, which is also referred to as the auricle or external ear. | 22 | 4.887440e-03 | 0 |
| HP | HP:0100547 | Abnormal forebrain morphology | An abnormality of the forebrain, which has as its parts the telencephalon, diencephalon, lateral ventricles and third ventricle. | 28 | 5.007408e-03 | 0 |
| HP | HP:0000925 | Abnormality of the vertebral column | Any abnormality of the vertebral column. | 24 | 5.399475e-03 | 0 |
| HP | HP:0000356 | Abnormality of the outer ear | An abnormality of the external ear. | 22 | 5.913788e-03 | 0 |
| HP | HP:0000078 | Abnormality of the genital system | An abnormality of the genital system. | 25 | 6.010131e-03 | 0 |
| HP | HP:0001167 | Abnormal finger morphology | An anomaly of a finger. | 21 | 8.093153e-03 | 0 |
| HP | HP:0007364 | Aplasia/Hypoplasia of the cerebrum | Aplasia/Hypoplasia of the cerebrum | 24 | 9.060630e-03 | 0 |
| HP | HP:0000277 | Abnormal mandible morphology | Any abnormality of the mandible, the bone of the lower jaw. | 20 | 9.433736e-03 | 0 |
| HP | HP:0000765 | Abnormal thorax morphology | Any abnormality of the thorax (the region of the body formed by the sternum, the thoracic vertebrae and the ribs). | 18 | 1.026710e-02 | 0 |
| HP | HP:0011138 | Abnormal skin adnexa morphology | An abnormality of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands. | 23 | 1.364963e-02 | 0 |
| HP | HP:0011821 | Abnormal facial skeleton morphology | An abnormality of one or more of the set of bones that make up the facial skeleton. | 22 | 1.494342e-02 | 0 |
| HP | HP:0004323 | Abnormality of body weight | An abnormal increase or decrease of weight or an abnormal distribution of mass in the body. | 25 | 2.406636e-02 | 0 |
| HP | HP:0000496 | Abnormality of eye movement | An abnormality in voluntary or involuntary eye movements or their control. | 25 | 2.569476e-02 | 0 |
| HP | HP:0004328 | Abnormal anterior eye segment morphology | An abnormality of the anterior segment of the eyeball (which comprises the structures in front of the vitreous humor: the cornea, iris, ciliary body, and lens). | 21 | 2.715743e-02 | 0 |
| HP | HP:0001155 | Abnormality of the hand | An abnormality affecting one or both hands. | 23 | 3.789906e-02 | 0 |
| HP | HP:0009115 | Aplasia/hypoplasia involving the skeleton | Absence (due to failure to form) or underdevelopment of one or more components of the skeleton. | 20 | 3.840026e-02 | 0 |
| HP | HP:0002817 | Abnormality of the upper limb | An abnormality of the arm. | 24 | 4.734875e-02 | 0 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 48 | 4.333505e-15 | 0 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 64 | 2.095668e-12 | 0 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 35 | 3.623352e-11 | 0 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 58 | 1.674215e-10 | 0 |
| HPA | HPA:0090163 | Cerebellum; Purkinje cells[High] | Cerebellum; Purkinje cells[High] | 37 | 5.727861e-10 | 0 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 32 | 7.189455e-10 | 0 |
| HPA | HPA:0620000 | Vagina | Vagina | 71 | 2.160084e-09 | 0 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 71 | 2.160084e-09 | 0 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 37 | 4.085375e-09 | 0 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 66 | 1.488553e-08 | 0 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 58 | 1.824864e-08 | 0 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 76 | 1.827198e-08 | 0 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 76 | 1.827198e-08 | 0 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 71 | 2.064584e-08 | 0 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 64 | 3.194716e-08 | 0 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 64 | 5.277303e-08 | 0 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 59 | 5.330257e-08 | 0 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 57 | 6.722330e-08 | 0 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 53 | 7.453893e-08 | 0 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 62 | 8.276618e-08 | 0 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 37 | 1.145234e-07 | 0 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 58 | 1.990959e-07 | 0 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 31 | 2.350130e-07 | 0 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 73 | 2.776258e-07 | 0 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 73 | 2.776258e-07 | 0 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 77 | 3.518241e-07 | 0 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 69 | 4.071327e-07 | 0 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 77 | 4.309005e-07 | 0 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 68 | 4.370591e-07 | 0 |
| HPA | HPA:0380521 | Placenta; trophoblastic cells[≥Low] | Placenta; trophoblastic cells[≥Low] | 70 | 4.542559e-07 | 0 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 45 | 5.134829e-07 | 0 |
| HPA | HPA:0400000 | Rectum | Rectum | 77 | 8.402057e-07 | 0 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 75 | 8.565998e-07 | 0 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 69 | 9.653053e-07 | 0 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 69 | 9.653053e-07 | 0 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 61 | 1.018402e-06 | 0 |
| HPA | HPA:0290401 | Liver; hepatocytes[≥Low] | Liver; hepatocytes[≥Low] | 66 | 1.106220e-06 | 0 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 27 | 1.183740e-06 | 0 |
| HPA | HPA:0290000 | Liver | Liver | 69 | 1.360922e-06 | 0 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 64 | 1.535332e-06 | 0 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 61 | 1.561412e-06 | 0 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 67 | 1.580677e-06 | 0 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 70 | 2.113022e-06 | 0 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 60 | 2.136839e-06 | 0 |
| HPA | HPA:0630000 | Cervix | Cervix | 72 | 2.195341e-06 | 0 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 72 | 2.572598e-06 | 0 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 54 | 2.610607e-06 | 0 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 61 | 2.917899e-06 | 0 |
| HPA | HPA:0080000 | Caudate | Caudate | 72 | 3.147625e-06 | 0 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 74 | 3.680330e-06 | 0 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 54 | 5.098387e-06 | 0 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 71 | 5.388805e-06 | 0 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 72 | 5.681531e-06 | 0 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 70 | 7.412951e-06 | 0 |
| HPA | HPA:0390000 | Prostate | Prostate | 70 | 7.412951e-06 | 0 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 59 | 9.625456e-06 | 0 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 27 | 1.155856e-05 | 0 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 75 | 1.417076e-05 | 0 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 61 | 1.443684e-05 | 0 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 57 | 1.942341e-05 | 0 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 64 | 1.960633e-05 | 0 |
| HPA | HPA:0030000 | Appendix | Appendix | 75 | 2.040199e-05 | 0 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 72 | 2.240531e-05 | 0 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 67 | 2.620984e-05 | 0 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 70 | 2.664004e-05 | 0 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 70 | 2.664004e-05 | 0 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 24 | 3.085408e-05 | 0 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 29 | 3.281463e-05 | 0 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 69 | 3.621943e-05 | 0 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 69 | 3.621943e-05 | 0 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 59 | 3.850030e-05 | 0 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 52 | 4.477559e-05 | 0 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 61 | 4.579428e-05 | 0 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 67 | 4.586246e-05 | 0 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 69 | 4.664362e-05 | 0 |
| HPA | HPA:0380000 | Placenta | Placenta | 73 | 5.663719e-05 | 0 |
| HPA | HPA:0570731 | Testis; Leydig cells[≥Low] | Testis; Leydig cells[≥Low] | 71 | 7.610331e-05 | 0 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 73 | 1.189201e-04 | 0 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 73 | 1.189201e-04 | 0 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 70 | 1.678511e-04 | 0 |
| HPA | HPA:0130000 | Colon | Colon | 76 | 1.837184e-04 | 0 |
| HPA | HPA:0090161 | Cerebellum; Purkinje cells[≥Low] | Cerebellum; Purkinje cells[≥Low] | 61 | 2.354496e-04 | 0 |
| HPA | HPA:0290402 | Liver; hepatocytes[≥Medium] | Liver; hepatocytes[≥Medium] | 48 | 2.428714e-04 | 0 |
| HPA | HPA:0530000 | Spleen | Spleen | 63 | 2.590789e-04 | 0 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 70 | 2.842739e-04 | 0 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 70 | 2.842739e-04 | 0 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 46 | 2.966314e-04 | 0 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 59 | 3.034606e-04 | 0 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 58 | 3.123468e-04 | 0 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 71 | 3.326252e-04 | 0 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 71 | 3.326252e-04 | 0 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 68 | 3.371316e-04 | 0 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 61 | 3.474494e-04 | 0 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 53 | 3.535314e-04 | 0 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 68 | 4.264407e-04 | 0 |
| HPA | HPA:0050000 | Breast | Breast | 70 | 4.457820e-04 | 0 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 68 | 4.495584e-04 | 0 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 21 | 4.507064e-04 | 0 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 67 | 4.733300e-04 | 0 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 18 | 4.827559e-04 | 0 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 66 | 5.579011e-04 | 0 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 66 | 5.579011e-04 | 0 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 61 | 5.751687e-04 | 0 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 71 | 5.881383e-04 | 0 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 61 | 5.883471e-04 | 0 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 49 | 6.190868e-04 | 0 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 71 | 6.199400e-04 | 0 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 70 | 6.892263e-04 | 0 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 23 | 6.995951e-04 | 0 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 67 | 8.268356e-04 | 0 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 72 | 8.547211e-04 | 0 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 72 | 8.547211e-04 | 0 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 36 | 8.659492e-04 | 0 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 63 | 8.877811e-04 | 0 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 47 | 9.137303e-04 | 0 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 68 | 9.384406e-04 | 0 |
| HPA | HPA:0380523 | Placenta; trophoblastic cells[High] | Placenta; trophoblastic cells[High] | 31 | 1.031597e-03 | 0 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 18 | 1.240294e-03 | 0 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 26 | 1.553663e-03 | 0 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 35 | 2.010579e-03 | 0 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 18 | 2.088700e-03 | 0 |
| HPA | HPA:0470682 | Skin 2; epidermal cells[≥Medium] | Skin 2; epidermal cells[≥Medium] | 48 | 2.152687e-03 | 0 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 17 | 2.313797e-03 | 0 |
| HPA | HPA:0270000 | Kidney | Kidney | 74 | 2.795782e-03 | 0 |
| HPA | HPA:0060101 | Bronchus; respiratory epithelial cells[≥Low] | Bronchus; respiratory epithelial cells[≥Low] | 61 | 2.877489e-03 | 0 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 24 | 2.971830e-03 | 0 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 71 | 3.645832e-03 | 0 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 71 | 3.645832e-03 | 0 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 37 | 3.687480e-03 | 0 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 25 | 4.145664e-03 | 0 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 62 | 4.268280e-03 | 0 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 73 | 5.035278e-03 | 0 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 25 | 5.571902e-03 | 0 |
| HPA | HPA:0570000 | Testis | Testis | 77 | 5.719020e-03 | 0 |
| HPA | HPA:0300000 | Lung | Lung | 69 | 6.491899e-03 | 0 |
| HPA | HPA:0340000 | Ovary | Ovary | 57 | 7.198624e-03 | 0 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 32 | 7.356773e-03 | 0 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 18 | 7.999514e-03 | 0 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 41 | 8.645838e-03 | 0 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 16 | 8.871451e-03 | 0 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 8 | 9.033702e-03 | 0 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 18 | 9.310577e-03 | 0 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 69 | 9.936006e-03 | 0 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 17 | 1.004909e-02 | 0 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 53 | 1.048251e-02 | 0 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 16 | 1.068140e-02 | 0 |
| HPA | HPA:0030433 | Appendix; germinal center cells[High] | Appendix; germinal center cells[High] | 6 | 1.109001e-02 | 0 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 58 | 1.188562e-02 | 0 |
| HPA | HPA:0031302 | Appendix; enterocytes[≥Medium] | Appendix; enterocytes[≥Medium] | 11 | 1.222981e-02 | 0 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 64 | 1.274558e-02 | 0 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 26 | 1.284148e-02 | 0 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 48 | 1.351941e-02 | 0 |
| HPA | HPA:0031292 | Appendix; endocrine cells[≥Medium] | Appendix; endocrine cells[≥Medium] | 11 | 1.419142e-02 | 0 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 15 | 1.446600e-02 | 0 |
| HPA | HPA:0400242 | Rectum; peripheral nerve/ganglion[≥Medium] | Rectum; peripheral nerve/ganglion[≥Medium] | 8 | 1.608680e-02 | 0 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 60 | 1.641546e-02 | 0 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 46 | 1.806206e-02 | 0 |
| HPA | HPA:0030892 | Appendix; goblet cells[≥Medium] | Appendix; goblet cells[≥Medium] | 10 | 1.870789e-02 | 0 |
| HPA | HPA:0131302 | Colon; enterocytes[≥Medium] | Colon; enterocytes[≥Medium] | 11 | 1.893894e-02 | 0 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 27 | 1.983092e-02 | 0 |
| HPA | HPA:0270361 | Kidney; cells in tubules[≥Low] | Kidney; cells in tubules[≥Low] | 66 | 2.039344e-02 | 0 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 11 | 2.229357e-02 | 0 |
| HPA | HPA:0480052 | Small intestine; glandular cells[≥Medium] | Small intestine; glandular cells[≥Medium] | 60 | 2.299706e-02 | 0 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 35 | 2.691391e-02 | 0 |
| HPA | HPA:0470683 | Skin 2; epidermal cells[High] | Skin 2; epidermal cells[High] | 19 | 2.839535e-02 | 0 |
| HPA | HPA:0400652 | Rectum; fibroblasts[≥Medium] | Rectum; fibroblasts[≥Medium] | 6 | 2.890411e-02 | 0 |
| HPA | HPA:0400052 | Rectum; glandular cells[≥Medium] | Rectum; glandular cells[≥Medium] | 60 | 2.898743e-02 | 0 |
| HPA | HPA:0030052 | Appendix; glandular cells[≥Medium] | Appendix; glandular cells[≥Medium] | 56 | 2.902031e-02 | 0 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 18 | 2.926191e-02 | 0 |
| HPA | HPA:0131292 | Colon; endocrine cells[≥Medium] | Colon; endocrine cells[≥Medium] | 11 | 3.055351e-02 | 0 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 10 | 3.195105e-02 | 0 |
| HPA | HPA:0401292 | Rectum; endocrine cells[≥Medium] | Rectum; endocrine cells[≥Medium] | 11 | 3.262868e-02 | 0 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 51 | 3.344887e-02 | 0 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 17 | 3.560413e-02 | 0 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 13 | 3.629017e-02 | 0 |
| HPA | HPA:0400891 | Rectum; goblet cells[≥Low] | Rectum; goblet cells[≥Low] | 11 | 3.714224e-02 | 0 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 15 | 3.718298e-02 | 0 |
| HPA | HPA:0400892 | Rectum; goblet cells[≥Medium] | Rectum; goblet cells[≥Medium] | 10 | 3.875209e-02 | 0 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 8 | 3.894057e-02 | 0 |
| HPA | HPA:0031291 | Appendix; endocrine cells[≥Low] | Appendix; endocrine cells[≥Low] | 11 | 4.490657e-02 | 0 |
| HPA | HPA:0460662 | Skin 1; keratinocytes[≥Medium] | Skin 1; keratinocytes[≥Medium] | 39 | 4.777809e-02 | 0 |
| HPA | HPA:0030431 | Appendix; germinal center cells[≥Low] | Appendix; germinal center cells[≥Low] | 9 | 4.779528e-02 | 0 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-100-5p | hsa-mir-100-5p | hsa-mir-100-5p | 13 | 5.363878e-07 | 0 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 27 | 6.111970e-07 | 0 |
| MIRNA | MIRNA:hsa-mir-652-3p | hsa-mir-652-3p | hsa-mir-652-3p | 10 | 1.512703e-06 | 0 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 27 | 9.863917e-06 | 0 |
| MIRNA | MIRNA:hsa-mir-1296-5p | hsa-mir-1296-5p | hsa-mir-1296-5p | 7 | 2.324420e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 17 | 8.689162e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-1915-5p | hsa-mir-1915-5p | hsa-mir-1915-5p | 5 | 1.061901e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-186-5p | hsa-mir-186-5p | hsa-mir-186-5p | 14 | 2.433745e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-766-3p | hsa-mir-766-3p | hsa-mir-766-3p | 11 | 4.221435e-02 | 0 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00025 | Factor: Elk-1; motif: NNNNCCGGAARTNN | Factor: Elk-1; motif: NNNNCCGGAARTNN | 75 | 0.000009 | 0 |
| TF | TF:M03975_1 | Factor: ERG; motif: ACCGGAARTN; match class: 1 | Factor: ERG; motif: ACCGGAARTN; match class: 1 | 44 | 0.000014 | 0 |
| TF | TF:M11400 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 74 | 0.000022 | 0 |
| TF | TF:M11392 | Factor: Erg; motif: NACCGGAARYN | Factor: Erg; motif: NACCGGAARYN | 68 | 0.000041 | 0 |
| TF | TF:M11392_1 | Factor: Erg; motif: NACCGGAARYN; match class: 1 | Factor: Erg; motif: NACCGGAARYN; match class: 1 | 38 | 0.000049 | 0 |
| TF | TF:M08913 | Factor: FLI-1; motif: NAYTTCCGGT | Factor: FLI-1; motif: NAYTTCCGGT | 66 | 0.000062 | 0 |
| TF | TF:M08205 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | 89 | 0.000084 | 0 |
| TF | TF:M03977 | Factor: ETS1; motif: ACCGGAARYN | Factor: ETS1; motif: ACCGGAARYN | 75 | 0.000132 | 0 |
| TF | TF:M02062 | Factor: Erg; motif: ACCGGAAGTN | Factor: Erg; motif: ACCGGAAGTN | 64 | 0.000145 | 0 |
| TF | TF:M02071 | Factor: ETV7; motif: NCCGGAANNN | Factor: ETV7; motif: NCCGGAANNN | 73 | 0.000213 | 0 |
| TF | TF:M11428 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 59 | 0.000312 | 0 |
| TF | TF:M00025_1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | 44 | 0.000331 | 0 |
| TF | TF:M11396_1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | 47 | 0.000358 | 0 |
| TF | TF:M12238_1 | Factor: DREF; motif: MTRTCGCGAYAK; match class: 1 | Factor: DREF; motif: MTRTCGCGAYAK; match class: 1 | 11 | 0.000358 | 0 |
| TF | TF:M02063 | Factor: c-ets-1; motif: ACCGGAWGTN | Factor: c-ets-1; motif: ACCGGAWGTN | 61 | 0.000359 | 0 |
| TF | TF:M04714 | Factor: Elf-1; motif: ACTTCCGGG | Factor: Elf-1; motif: ACTTCCGGG | 62 | 0.000398 | 0 |
| TF | TF:M02065_1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | 58 | 0.000421 | 0 |
| TF | TF:M04691_1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | 74 | 0.000422 | 0 |
| TF | TF:M08913_1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | 35 | 0.000449 | 0 |
| TF | TF:M11396 | Factor: Erg; motif: NACCGGAARTN | Factor: Erg; motif: NACCGGAARTN | 75 | 0.000455 | 0 |
| TF | TF:M11530_1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | 85 | 0.000455 | 0 |
| TF | TF:M09905 | Factor: SAP-1; motif: NNCCGGAAGTGN | Factor: SAP-1; motif: NNCCGGAAGTGN | 64 | 0.000556 | 0 |
| TF | TF:M03977_1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | 45 | 0.000585 | 0 |
| TF | TF:M01752_1 | Factor: ERG; motif: ACCGGAART; match class: 1 | Factor: ERG; motif: ACCGGAART; match class: 1 | 39 | 0.000597 | 0 |
| TF | TF:M02070 | Factor: TEL1; motif: CNCGGAANNN | Factor: TEL1; motif: CNCGGAANNN | 75 | 0.000668 | 0 |
| TF | TF:M11400_1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | 42 | 0.000672 | 0 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 92 | 0.000672 | 0 |
| TF | TF:M07140 | Factor: Kaiso; motif: NTCTCGCGAGANYTN | Factor: Kaiso; motif: NTCTCGCGAGANYTN | 14 | 0.000719 | 0 |
| TF | TF:M07140_1 | Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 | Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 | 9 | 0.000796 | 0 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 89 | 0.000813 | 0 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 91 | 0.000845 | 0 |
| TF | TF:M03975 | Factor: ERG; motif: ACCGGAARTN | Factor: ERG; motif: ACCGGAARTN | 71 | 0.000999 | 0 |
| TF | TF:M02073 | Factor: Fli-1; motif: ACCGGAAGYN | Factor: Fli-1; motif: ACCGGAAGYN | 51 | 0.001060 | 0 |
| TF | TF:M11530 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | 88 | 0.001099 | 0 |
| TF | TF:M10438 | Factor: ZF5; motif: GGSGCGCGS | Factor: ZF5; motif: GGSGCGCGS | 92 | 0.001324 | 0 |
| TF | TF:M04710_1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | 77 | 0.001333 | 0 |
| TF | TF:M08298_1 | Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN; match class: 1 | Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN; match class: 1 | 39 | 0.001617 | 0 |
| TF | TF:M03988_1 | Factor: FLI1; motif: ACCGGAARTN; match class: 1 | Factor: FLI1; motif: ACCGGAARTN; match class: 1 | 33 | 0.001963 | 0 |
| TF | TF:M12238 | Factor: DREF; motif: MTRTCGCGAYAK | Factor: DREF; motif: MTRTCGCGAYAK | 11 | 0.002031 | 0 |
| TF | TF:M11447 | Factor: Elf-1; motif: NAMCCGGAAGTN | Factor: Elf-1; motif: NAMCCGGAAGTN | 60 | 0.002188 | 0 |
| TF | TF:M13031_1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | 45 | 0.002225 | 0 |
| TF | TF:M01167 | Factor: SAP-1a; motif: NACCGGAAGTV | Factor: SAP-1a; motif: NACCGGAAGTV | 26 | 0.002369 | 0 |
| TF | TF:M09608_1 | Factor: Erg; motif: NNACCGGAARTSN; match class: 1 | Factor: Erg; motif: NNACCGGAARTSN; match class: 1 | 29 | 0.002401 | 0 |
| TF | TF:M01078 | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN | 59 | 0.002544 | 0 |
| TF | TF:M11018_1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | 91 | 0.002929 | 0 |
| TF | TF:M02074 | Factor: GABPalpha; motif: RCCGGAWRYN | Factor: GABPalpha; motif: RCCGGAWRYN | 43 | 0.002984 | 0 |
| TF | TF:M03966 | Factor: ELF1; motif: AACCCGGAAGTR | Factor: ELF1; motif: AACCCGGAAGTR | 54 | 0.003202 | 0 |
| TF | TF:M11404_1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | 34 | 0.003594 | 0 |
| TF | TF:M09966_1 | Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 | Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 | 12 | 0.003598 | 0 |
| TF | TF:M12600 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | 64 | 0.003617 | 0 |
| TF | TF:M03982 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 55 | 0.003738 | 0 |
| TF | TF:M02065 | Factor: ER81; motif: RCCGGAARYN | Factor: ER81; motif: RCCGGAARYN | 81 | 0.004046 | 0 |
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 89 | 0.004437 | 0 |
| TF | TF:M02052 | Factor: EHF; motif: CSCGGAARTN | Factor: EHF; motif: CSCGGAARTN | 70 | 0.004954 | 0 |
| TF | TF:M03988 | Factor: FLI1; motif: ACCGGAARTN | Factor: FLI1; motif: ACCGGAARTN | 62 | 0.005022 | 0 |
| TF | TF:M11404 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 64 | 0.005123 | 0 |
| TF | TF:M11451 | Factor: Elf-1; motif: NANCCGGAAGTN | Factor: Elf-1; motif: NANCCGGAAGTN | 55 | 0.005485 | 0 |
| TF | TF:M02059 | Factor: ELK-1; motif: ACCGGAAGTN | Factor: ELK-1; motif: ACCGGAAGTN | 67 | 0.005805 | 0 |
| TF | TF:M08266_1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | 65 | 0.006219 | 0 |
| TF | TF:M09904 | Factor: Elk-1; motif: RCCGGAAGTGN | Factor: Elk-1; motif: RCCGGAAGTGN | 61 | 0.006761 | 0 |
| TF | TF:M08229 | Factor: Elk-1:SREBP-2; motif: RTCACGTGACCGGAAGN | Factor: Elk-1:SREBP-2; motif: RTCACGTGACCGGAAGN | 67 | 0.007657 | 0 |
| TF | TF:M08223_1 | Factor: Elk-1:OC-2; motif: RCCGGAASCGATCGATNN; match class: 1 | Factor: Elk-1:OC-2; motif: RCCGGAASCGATCGATNN; match class: 1 | 49 | 0.008119 | 0 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 88 | 0.008393 | 0 |
| TF | TF:M11425 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 57 | 0.009205 | 0 |
| TF | TF:M03970 | Factor: ELK1; motif: ACCGGAAGTN | Factor: ELK1; motif: ACCGGAAGTN | 43 | 0.009458 | 0 |
| TF | TF:M09632_1 | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN; match class: 1 | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN; match class: 1 | 14 | 0.010791 | 0 |
| TF | TF:M11435 | Factor: Elk-1; motif: NNCCGGAAGTN | Factor: Elk-1; motif: NNCCGGAAGTN | 76 | 0.012264 | 0 |
| TF | TF:M08759 | Factor: c-Ets-2; motif: NCCGGAAGTG | Factor: c-Ets-2; motif: NCCGGAAGTG | 61 | 0.013762 | 0 |
| TF | TF:M13031 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 72 | 0.015405 | 0 |
| TF | TF:M09904_1 | Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 | Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 | 30 | 0.015824 | 0 |
| TF | TF:M11420 | Factor: ER81; motif: NACCGGAAGTN | Factor: ER81; motif: NACCGGAAGTN | 33 | 0.015911 | 0 |
| TF | TF:M11414 | Factor: GABP-alpha; motif: NACCGGAAGTN | Factor: GABP-alpha; motif: NACCGGAAGTN | 31 | 0.017150 | 0 |
| TF | TF:M01752 | Factor: ERG; motif: ACCGGAART | Factor: ERG; motif: ACCGGAART | 66 | 0.017237 | 0 |
| TF | TF:M08759_1 | Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 | Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 | 31 | 0.018133 | 0 |
| TF | TF:M08286 | Factor: Fli-1:FOXI1; motif: NCCGGATGTTKAY | Factor: Fli-1:FOXI1; motif: NCCGGATGTTKAY | 40 | 0.018897 | 0 |
| TF | TF:M01660 | Factor: GABP-alpha; motif: CTTCCK | Factor: GABP-alpha; motif: CTTCCK | 73 | 0.020500 | 0 |
| TF | TF:M02053_1 | Factor: ELF1; motif: NCCGGAARTN; match class: 1 | Factor: ELF1; motif: NCCGGAARTN; match class: 1 | 21 | 0.024278 | 0 |
| TF | TF:M02056 | Factor: ELF4; motif: NCCGGAARTN | Factor: ELF4; motif: NCCGGAARTN | 45 | 0.026623 | 0 |
| TF | TF:M00430 | Factor: E2F-1; motif: NTTSGCGG | Factor: E2F-1; motif: NTTSGCGG | 59 | 0.028971 | 0 |
| TF | TF:M00327_1 | Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 | Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 | 53 | 0.029534 | 0 |
| TF | TF:M03983 | Factor: ETV5; motif: NCCGGAWGYN | Factor: ETV5; motif: NCCGGAWGYN | 32 | 0.029792 | 0 |
| TF | TF:M11452 | Factor: Elf-1; motif: NANGCGGAAGTR | Factor: Elf-1; motif: NANGCGGAAGTR | 50 | 0.029793 | 0 |
| TF | TF:M08525_1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | 88 | 0.030113 | 0 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 92 | 0.030793 | 0 |
| TF | TF:M02071_1 | Factor: ETV7; motif: NCCGGAANNN; match class: 1 | Factor: ETV7; motif: NCCGGAANNN; match class: 1 | 40 | 0.031957 | 0 |
| TF | TF:M09606 | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | 50 | 0.032467 | 0 |
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 81 | 0.033623 | 0 |
| TF | TF:M02069 | Factor: Erm; motif: ACCGGAAGTN | Factor: Erm; motif: ACCGGAAGTN | 53 | 0.035360 | 0 |
| TF | TF:M11432 | Factor: Elk-1; motif: NACMGGAAGTN | Factor: Elk-1; motif: NACMGGAAGTN | 49 | 0.036275 | 0 |
| TF | TF:M10785 | Factor: hoxa9; motif: RTCGTWANNN | Factor: hoxa9; motif: RTCGTWANNN | 46 | 0.036298 | 0 |
| TF | TF:M01876 | Factor: GABP-beta; motif: ASMGGAAGKGN | Factor: GABP-beta; motif: ASMGGAAGKGN | 25 | 0.038780 | 0 |
| TF | TF:M10632 | Factor: Nkx2-8; motif: STCGTTGAN | Factor: Nkx2-8; motif: STCGTTGAN | 42 | 0.039518 | 0 |
| TF | TF:M02070_1 | Factor: TEL1; motif: CNCGGAANNN; match class: 1 | Factor: TEL1; motif: CNCGGAANNN; match class: 1 | 42 | 0.040565 | 0 |
| TF | TF:M13032 | Factor: ETV5; motif: ACCGGAAGTN | Factor: ETV5; motif: ACCGGAAGTN | 65 | 0.045068 | 0 |
| TF | TF:M01163 | Factor: Elk-1; motif: AACCGGAAGTR | Factor: Elk-1; motif: AACCGGAAGTR | 44 | 0.045888 | 0 |
| TF | TF:M11402 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 36 | 0.047123 | 0 |
| TF | TF:M11424 | Factor: Erm; motif: NNSCGGAWGYN | Factor: Erm; motif: NNSCGGAWGYN | 59 | 0.047193 | 0 |
Community 1
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 72 | 6.009224e-35 | 1 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 79 | 7.268717e-30 | 1 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 79 | 7.268717e-30 | 1 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 79 | 7.268717e-30 | 1 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 74 | 1.720102e-29 | 1 |
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 19 | 2.010502e-18 | 1 |
| GO:CC | GO:0071013 | catalytic step 2 spliceosome | "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 15 | 3.160598e-18 | 1 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 80 | 1.081730e-17 | 1 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 73 | 1.108290e-17 | 1 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 40 | 5.450884e-17 | 1 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 37 | 6.318209e-16 | 1 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 43 | 4.701282e-15 | 1 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 59 | 1.475600e-14 | 1 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 64 | 2.370531e-14 | 1 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 64 | 2.390031e-14 | 1 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 26 | 1.254326e-13 | 1 |
| GO:CC | GO:0032993 | protein-DNA complex | "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] | 15 | 1.018412e-11 | 1 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 34 | 5.153223e-11 | 1 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 34 | 7.741406e-11 | 1 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 34 | 7.846198e-11 | 1 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 34 | 7.846198e-11 | 1 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 28 | 9.154048e-11 | 1 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 14 | 1.347858e-10 | 1 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 84 | 1.646472e-09 | 1 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 86 | 1.670544e-09 | 1 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 36 | 2.713856e-09 | 1 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 10 | 1.853786e-08 | 1 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 21 | 2.321186e-08 | 1 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 10 | 4.409272e-07 | 1 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 86 | 6.123623e-07 | 1 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 40 | 7.921470e-07 | 1 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 10 | 8.975088e-07 | 1 |
| GO:CC | GO:0005684 | U2-type spliceosomal complex | "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900] | 8 | 1.098696e-06 | 1 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 12 | 1.603508e-06 | 1 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 11 | 1.768324e-06 | 1 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 12 | 1.903987e-06 | 1 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 12 | 1.969840e-06 | 1 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 84 | 2.080027e-06 | 1 |
| GO:CC | GO:0016607 | nuclear speck | "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640] | 13 | 3.027606e-06 | 1 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 87 | 3.396234e-06 | 1 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 11 | 3.693305e-06 | 1 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 18 | 3.977453e-06 | 1 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 34 | 1.114985e-05 | 1 |
| GO:CC | GO:0090734 | site of DNA damage | "A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg] | 8 | 1.346140e-05 | 1 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 73 | 1.568801e-05 | 1 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 28 | 2.132606e-05 | 1 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 12 | 3.374873e-05 | 1 |
| GO:CC | GO:0035861 | site of double-strand break | "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] | 7 | 3.723754e-05 | 1 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 12 | 4.335371e-05 | 1 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 38 | 4.900071e-05 | 1 |
| GO:CC | GO:0005662 | DNA replication factor A complex | "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] | 4 | 4.921078e-05 | 1 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 22 | 1.013610e-04 | 1 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 7 | 1.052884e-04 | 1 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 7 | 1.052884e-04 | 1 |
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 6 | 1.591479e-04 | 1 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 11 | 1.671772e-04 | 1 |
| GO:CC | GO:0043596 | nuclear replication fork | "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] | 5 | 1.777151e-04 | 1 |
| GO:CC | GO:0070418 | DNA-dependent protein kinase complex | "A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku." [GOC:mah, PMID:10854421, PMID:12235392] | 3 | 1.853656e-04 | 1 |
| GO:CC | GO:0016363 | nuclear matrix | "A dynamic, proteinaceous framework within the nucleus of eukaryotic cells, composed of proteins and RNA, that provides structural support for chromatin organization, gene regulation, and nuclear processes." [PMID:15608168, PMID:3058729, PMID:39789220] | 7 | 2.439076e-04 | 1 |
| GO:CC | GO:0071005 | U2-type precatalytic spliceosome | "A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] | 5 | 4.886953e-04 | 1 |
| GO:CC | GO:0043601 | nuclear replisome | "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] | 4 | 4.900548e-04 | 1 |
| GO:CC | GO:0000123 | histone acetyltransferase complex | "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] | 6 | 5.343481e-04 | 1 |
| GO:CC | GO:1990391 | DNA repair complex | "A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350] | 4 | 5.914483e-04 | 1 |
| GO:CC | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex | "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV." [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889] | 3 | 6.450951e-04 | 1 |
| GO:CC | GO:0030894 | replisome | "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] | 4 | 7.076135e-04 | 1 |
| GO:CC | GO:0071011 | precatalytic spliceosome | "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] | 5 | 8.648983e-04 | 1 |
| GO:CC | GO:0031248 | protein acetyltransferase complex | "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf] | 6 | 9.779385e-04 | 1 |
| GO:CC | GO:1902493 | acetyltransferase complex | "A protein complex which is capable of acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 6 | 1.035182e-03 | 1 |
| GO:CC | GO:0005689 | U12-type spliceosomal complex | "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955] | 4 | 1.158239e-03 | 1 |
| GO:CC | GO:0098978 | glutamatergic synapse | "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] | 12 | 1.283949e-03 | 1 |
| GO:CC | GO:0016605 | PML body | "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585] | 6 | 1.363861e-03 | 1 |
| GO:CC | GO:0070419 | nonhomologous end joining complex | "A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends." [GOC:mah, PMID:17072889, PMID:17938628] | 3 | 1.539438e-03 | 1 |
| GO:CC | GO:0000791 | euchromatin | "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156] | 5 | 1.684329e-03 | 1 |
| GO:CC | GO:0071007 | U2-type catalytic step 2 spliceosome | "A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 4 | 1.792449e-03 | 1 |
| GO:CC | GO:0005730 | nucleolus | "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] | 22 | 1.862009e-03 | 1 |
| GO:CC | GO:0008180 | COP9 signalosome | "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] | 4 | 3.373744e-03 | 1 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 14 | 3.595178e-03 | 1 |
| GO:CC | GO:0101031 | protein folding chaperone complex | "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] | 4 | 6.409024e-03 | 1 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 15 | 7.210118e-03 | 1 |
| GO:CC | GO:1902562 | H4 histone acetyltransferase complex | "A protein complex which is capable of H4 histone acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:23775086] | 4 | 7.763578e-03 | 1 |
| GO:CC | GO:0010494 | cytoplasmic stress granule | "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] | 5 | 1.050031e-02 | 1 |
| GO:CC | GO:0048471 | perinuclear region of cytoplasm | "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] | 12 | 1.089105e-02 | 1 |
| GO:CC | GO:0043564 | Ku70:Ku80 complex | "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983] | 2 | 1.453477e-02 | 1 |
| GO:CC | GO:0034708 | methyltransferase complex | "A protein complex that possesses methyltransferase activity." [GOC:mah] | 5 | 1.715122e-02 | 1 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 13 | 1.740462e-02 | 1 |
| GO:CC | GO:0120293 | dynein axonemal particle | "An aggregation of axonemal dyneins, their specific assembly factors, and broadly-acting chaperones that is located in the cytoplasm." [GOC:krc, PMID:30561330, PMID:32898505, PMID:33263282] | 3 | 2.024891e-02 | 1 |
| GO:CC | GO:1904949 | ATPase complex | "A protein complex which is capable of ATPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181] | 5 | 4.800199e-02 | 1 |
| GO:CC | GO:0097255 | R2TP complex | "A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213] | 2 | 4.820171e-02 | 1 |
| GO:CC | GO:0106002 | mCRD-mediated mRNA stability complex | "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP." [GOC:bhm, PMID:11051545] | 2 | 4.820171e-02 | 1 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 49 | 3.253126e-26 | 1 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 38 | 5.071069e-24 | 1 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 68 | 2.943737e-21 | 1 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 20 | 6.974424e-21 | 1 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 55 | 2.339582e-20 | 1 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 57 | 2.497005e-20 | 1 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 33 | 1.292852e-19 | 1 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 20 | 1.615291e-19 | 1 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 58 | 3.386122e-19 | 1 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 49 | 1.271970e-18 | 1 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 28 | 1.718434e-18 | 1 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 74 | 2.688816e-18 | 1 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 57 | 4.931579e-18 | 1 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 47 | 1.816429e-17 | 1 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 69 | 3.061366e-17 | 1 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 75 | 3.578143e-17 | 1 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 71 | 6.172761e-17 | 1 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 65 | 5.414159e-16 | 1 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 24 | 5.758634e-16 | 1 |
| GO:BP | GO:0080134 | regulation of response to stress | "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 35 | 6.036193e-16 | 1 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 39 | 1.378574e-15 | 1 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 64 | 1.386895e-15 | 1 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 66 | 1.836554e-15 | 1 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 40 | 4.359276e-15 | 1 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 61 | 3.464834e-14 | 1 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 61 | 9.489108e-14 | 1 |
| GO:BP | GO:0006302 | double-strand break repair | "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] | 19 | 9.631998e-14 | 1 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 50 | 1.330254e-13 | 1 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 23 | 1.906651e-13 | 1 |
| GO:BP | GO:0080135 | regulation of cellular response to stress | "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 22 | 3.086673e-13 | 1 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 65 | 1.102848e-12 | 1 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 13 | 2.174926e-12 | 1 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 39 | 3.433728e-12 | 1 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 35 | 3.777835e-12 | 1 |
| GO:BP | GO:0000725 | recombinational repair | "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] | 15 | 5.127081e-12 | 1 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 83 | 8.541443e-12 | 1 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 75 | 1.018126e-11 | 1 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 65 | 1.126803e-11 | 1 |
| GO:BP | GO:0048511 | rhythmic process | "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] | 17 | 1.538814e-11 | 1 |
| GO:BP | GO:0006325 | chromatin organization | "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] | 25 | 2.200833e-11 | 1 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 49 | 2.216823e-11 | 1 |
| GO:BP | GO:0006338 | chromatin remodeling | "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] | 23 | 2.865320e-11 | 1 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 46 | 3.757162e-11 | 1 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 35 | 4.210022e-11 | 1 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 35 | 4.472332e-11 | 1 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 45 | 4.625186e-11 | 1 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 31 | 5.516363e-11 | 1 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 45 | 5.693199e-11 | 1 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 34 | 1.053043e-10 | 1 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 65 | 1.064089e-10 | 1 |
| GO:BP | GO:0006310 | DNA recombination | "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] | 17 | 1.275977e-10 | 1 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 32 | 1.354902e-10 | 1 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 32 | 1.399739e-10 | 1 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 81 | 1.726669e-10 | 1 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 72 | 1.813009e-10 | 1 |
| GO:BP | GO:0016032 | viral process | "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah] | 18 | 2.385584e-10 | 1 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 30 | 2.643406e-10 | 1 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 29 | 2.898196e-10 | 1 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] | 32 | 3.640799e-10 | 1 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 42 | 4.907829e-10 | 1 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 25 | 8.318280e-10 | 1 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 29 | 8.644548e-10 | 1 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 10 | 9.429752e-10 | 1 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 43 | 9.475090e-10 | 1 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 76 | 1.053274e-09 | 1 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 16 | 1.117241e-09 | 1 |
| GO:BP | GO:0002833 | positive regulation of response to biotic stimulus | "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] | 17 | 1.273661e-09 | 1 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 39 | 1.644955e-09 | 1 |
| GO:BP | GO:0000724 | double-strand break repair via homologous recombination | "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] | 13 | 1.919610e-09 | 1 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 60 | 2.309674e-09 | 1 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 55 | 2.382256e-09 | 1 |
| GO:BP | GO:0033044 | regulation of chromosome organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] | 14 | 2.741057e-09 | 1 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 40 | 3.601903e-09 | 1 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 38 | 4.050968e-09 | 1 |
| GO:BP | GO:0002218 | activation of innate immune response | "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805] | 15 | 4.205496e-09 | 1 |
| GO:BP | GO:0045089 | positive regulation of innate immune response | "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] | 16 | 5.963779e-09 | 1 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 9 | 6.289714e-09 | 1 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 79 | 6.497208e-09 | 1 |
| GO:BP | GO:0009628 | response to abiotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] | 25 | 6.941184e-09 | 1 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 69 | 7.459675e-09 | 1 |
| GO:BP | GO:0045088 | regulation of innate immune response | "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] | 17 | 8.067535e-09 | 1 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 60 | 9.613096e-09 | 1 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 9 | 9.969168e-09 | 1 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 55 | 1.134058e-08 | 1 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 37 | 1.440550e-08 | 1 |
| GO:BP | GO:0002831 | regulation of response to biotic stimulus | "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] | 18 | 1.446872e-08 | 1 |
| GO:BP | GO:0045087 | innate immune response | "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] | 23 | 1.616828e-08 | 1 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 49 | 1.698264e-08 | 1 |
| GO:BP | GO:0006282 | regulation of DNA repair | "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] | 13 | 1.885911e-08 | 1 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 29 | 2.109814e-08 | 1 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 14 | 2.268650e-08 | 1 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 84 | 2.668528e-08 | 1 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 14 | 3.294948e-08 | 1 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 31 | 3.560431e-08 | 1 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 23 | 4.938684e-08 | 1 |
| GO:BP | GO:0050789 | regulation of biological process | "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] | 79 | 5.900148e-08 | 1 |
| GO:BP | GO:0098542 | defense response to other organism | "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] | 25 | 5.921115e-08 | 1 |
| GO:BP | GO:0009607 | response to biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] | 28 | 8.191606e-08 | 1 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 35 | 8.425464e-08 | 1 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 15 | 9.562296e-08 | 1 |
| GO:BP | GO:0140546 | defense response to symbiont | "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg] | 23 | 1.090423e-07 | 1 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 26 | 1.141326e-07 | 1 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] | 32 | 1.323682e-07 | 1 |
| GO:BP | GO:0007623 | circadian rhythm | "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] | 12 | 1.437283e-07 | 1 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 24 | 1.542048e-07 | 1 |
| GO:BP | GO:0010628 | positive regulation of gene expression | "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 24 | 1.622679e-07 | 1 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 40 | 2.823966e-07 | 1 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 11 | 2.829867e-07 | 1 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 40 | 3.034014e-07 | 1 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 12 | 3.037885e-07 | 1 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 24 | 3.369030e-07 | 1 |
| GO:BP | GO:0019079 | viral genome replication | "Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534] | 10 | 3.606189e-07 | 1 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 18 | 4.048603e-07 | 1 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 24 | 4.954101e-07 | 1 |
| GO:BP | GO:0065007 | biological regulation | "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 79 | 5.333835e-07 | 1 |
| GO:BP | GO:0031349 | positive regulation of defense response | "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah] | 16 | 5.346057e-07 | 1 |
| GO:BP | GO:0045739 | positive regulation of DNA repair | "Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators] | 10 | 5.619421e-07 | 1 |
| GO:BP | GO:0042221 | response to chemical | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] | 42 | 6.290595e-07 | 1 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 24 | 6.375372e-07 | 1 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 20 | 7.078473e-07 | 1 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 36 | 7.850758e-07 | 1 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 22 | 7.972096e-07 | 1 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 36 | 9.320877e-07 | 1 |
| GO:BP | GO:0030522 | intracellular receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to a receptor located within a cell." [GOC:bf, GOC:mah] | 14 | 1.003558e-06 | 1 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 24 | 1.012811e-06 | 1 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 20 | 1.299065e-06 | 1 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 35 | 1.319748e-06 | 1 |
| GO:BP | GO:0051707 | response to other organism | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] | 26 | 1.434549e-06 | 1 |
| GO:BP | GO:0043207 | response to external biotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] | 26 | 1.493625e-06 | 1 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 63 | 1.666902e-06 | 1 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 36 | 1.712722e-06 | 1 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 32 | 1.931944e-06 | 1 |
| GO:BP | GO:0042026 | protein refolding | "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] | 6 | 2.527907e-06 | 1 |
| GO:BP | GO:0050778 | positive regulation of immune response | "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 18 | 3.661863e-06 | 1 |
| GO:BP | GO:0010569 | regulation of double-strand break repair via homologous recombination | "Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb] | 8 | 4.120165e-06 | 1 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 24 | 4.914896e-06 | 1 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 24 | 4.983182e-06 | 1 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 39 | 5.583039e-06 | 1 |
| GO:BP | GO:0034502 | protein localization to chromosome | "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah] | 9 | 5.616886e-06 | 1 |
| GO:BP | GO:0002684 | positive regulation of immune system process | "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] | 21 | 6.087771e-06 | 1 |
| GO:BP | GO:1904356 | regulation of telomere maintenance via telomere lengthening | "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 7 | 6.099469e-06 | 1 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] | 25 | 6.288576e-06 | 1 |
| GO:BP | GO:0002682 | regulation of immune system process | "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] | 25 | 6.537020e-06 | 1 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 16 | 7.205860e-06 | 1 |
| GO:BP | GO:0009605 | response to external stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] | 31 | 7.215092e-06 | 1 |
| GO:BP | GO:0006952 | defense response | "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] | 27 | 7.426283e-06 | 1 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 11 | 9.261750e-06 | 1 |
| GO:BP | GO:0031347 | regulation of defense response | "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] | 18 | 9.757789e-06 | 1 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 36 | 9.850016e-06 | 1 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 11 | 1.149400e-05 | 1 |
| GO:BP | GO:0043484 | regulation of RNA splicing | "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] | 10 | 1.169599e-05 | 1 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 13 | 1.189707e-05 | 1 |
| GO:BP | GO:0019058 | viral life cycle | "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272] | 12 | 1.226127e-05 | 1 |
| GO:BP | GO:0045727 | positive regulation of translation | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] | 9 | 1.255731e-05 | 1 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 12 | 1.317564e-05 | 1 |
| GO:BP | GO:1903311 | regulation of mRNA metabolic process | "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 12 | 1.317564e-05 | 1 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 17 | 1.342392e-05 | 1 |
| GO:BP | GO:0006986 | response to unfolded protein | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] | 9 | 1.425331e-05 | 1 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] | 34 | 1.530124e-05 | 1 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 20 | 1.627687e-05 | 1 |
| GO:BP | GO:0032103 | positive regulation of response to external stimulus | "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] | 16 | 1.632238e-05 | 1 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 22 | 1.648269e-05 | 1 |
| GO:BP | GO:2000779 | regulation of double-strand break repair | "Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF] | 9 | 1.717374e-05 | 1 |
| GO:BP | GO:0050776 | regulation of immune response | "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] | 19 | 1.826026e-05 | 1 |
| GO:BP | GO:0002253 | activation of immune response | "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] | 15 | 1.954019e-05 | 1 |
| GO:BP | GO:0034605 | cellular response to heat | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] | 7 | 2.023952e-05 | 1 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] | 18 | 2.220033e-05 | 1 |
| GO:BP | GO:1901698 | response to nitrogen compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 20 | 2.655914e-05 | 1 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 60 | 2.793794e-05 | 1 |
| GO:BP | GO:0051169 | nuclear transport | "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] | 12 | 2.813965e-05 | 1 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] | 12 | 2.813965e-05 | 1 |
| GO:BP | GO:0008380 | RNA splicing | "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] | 26 | 2.916024e-05 | 1 |
| GO:BP | GO:0002376 | immune system process | "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] | 33 | 2.919476e-05 | 1 |
| GO:BP | GO:0035966 | response to topologically incorrect protein | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] | 9 | 3.887832e-05 | 1 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] | 21 | 3.971057e-05 | 1 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 20 | 4.390606e-05 | 1 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 18 | 4.414553e-05 | 1 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 32 | 4.799185e-05 | 1 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 37 | 4.818982e-05 | 1 |
| GO:BP | GO:1905168 | positive regulation of double-strand break repair via homologous recombination | "Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299] | 6 | 4.938114e-05 | 1 |
| GO:BP | GO:0042752 | regulation of circadian rhythm | "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] | 8 | 5.182246e-05 | 1 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 32 | 5.327912e-05 | 1 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 12 | 6.637735e-05 | 1 |
| GO:BP | GO:0043687 | post-translational protein modification | "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] | 19 | 6.698963e-05 | 1 |
| GO:BP | GO:0032210 | regulation of telomere maintenance via telomerase | "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 6 | 7.512251e-05 | 1 |
| GO:BP | GO:0009266 | response to temperature stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] | 9 | 7.755848e-05 | 1 |
| GO:BP | GO:0010647 | positive regulation of cell communication | "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 25 | 8.325139e-05 | 1 |
| GO:BP | GO:0023056 | positive regulation of signaling | "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 25 | 8.416855e-05 | 1 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 12 | 8.442111e-05 | 1 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] | 24 | 9.033594e-05 | 1 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 24 | 9.241984e-05 | 1 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 24 | 1.047048e-04 | 1 |
| GO:BP | GO:0010629 | negative regulation of gene expression | "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 24 | 1.047048e-04 | 1 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 20 | 1.186376e-04 | 1 |
| GO:BP | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] | 8 | 1.449667e-04 | 1 |
| GO:BP | GO:0016071 | mRNA metabolic process | "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 27 | 1.570825e-04 | 1 |
| GO:BP | GO:0070647 | protein modification by small protein conjugation or removal | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] | 18 | 1.701333e-04 | 1 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 15 | 2.369679e-04 | 1 |
| GO:BP | GO:0030162 | regulation of proteolysis | "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] | 12 | 2.388870e-04 | 1 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 22 | 2.450347e-04 | 1 |
| GO:BP | GO:2000781 | positive regulation of double-strand break repair | "Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF] | 7 | 2.508756e-04 | 1 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 9 | 2.751137e-04 | 1 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 18 | 3.013217e-04 | 1 |
| GO:BP | GO:0000018 | regulation of DNA recombination | "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732] | 8 | 3.204182e-04 | 1 |
| GO:BP | GO:0006955 | immune response | "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add] | 26 | 3.268181e-04 | 1 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 19 | 3.841340e-04 | 1 |
| GO:BP | GO:0009408 | response to heat | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] | 7 | 4.434903e-04 | 1 |
| GO:BP | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] | 23 | 5.216130e-04 | 1 |
| GO:BP | GO:0000398 | mRNA splicing, via spliceosome | "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] | 23 | 5.216130e-04 | 1 |
| GO:BP | GO:0071383 | cellular response to steroid hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah] | 9 | 5.340515e-04 | 1 |
| GO:BP | GO:0000375 | RNA splicing, via transesterification reactions | "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] | 23 | 5.440885e-04 | 1 |
| GO:BP | GO:0002758 | innate immune response-activating signaling pathway | "The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an innate immune response." [GOC:jy, GOC:mah, PMID:11418339, PMID:28105028] | 10 | 6.005479e-04 | 1 |
| GO:BP | GO:1901796 | regulation of signal transduction by p53 class mediator | "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 7 | 6.179982e-04 | 1 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 13 | 6.458772e-04 | 1 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 9 | 6.753021e-04 | 1 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] | 18 | 7.971663e-04 | 1 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 14 | 8.464470e-04 | 1 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 29 | 8.611638e-04 | 1 |
| GO:BP | GO:0010608 | post-transcriptional regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] | 18 | 8.643508e-04 | 1 |
| GO:BP | GO:0030097 | hemopoiesis | "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] | 17 | 9.393545e-04 | 1 |
| GO:BP | GO:0000380 | alternative mRNA splicing, via spliceosome | "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] | 6 | 1.057576e-03 | 1 |
| GO:BP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 8 | 1.142804e-03 | 1 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 21 | 1.189178e-03 | 1 |
| GO:BP | GO:0062207 | regulation of pattern recognition receptor signaling pathway | "Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168] | 8 | 1.248989e-03 | 1 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 6 | 1.354468e-03 | 1 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 6 | 1.467395e-03 | 1 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 17 | 1.533077e-03 | 1 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 8 | 1.552059e-03 | 1 |
| GO:BP | GO:0062197 | cellular response to chemical stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] | 10 | 1.641632e-03 | 1 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 16 | 1.829288e-03 | 1 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 12 | 1.851690e-03 | 1 |
| GO:BP | GO:0045911 | positive regulation of DNA recombination | "Any process that activates or increases the frequency, rate or extent of DNA recombination." [GOC:go_curators] | 6 | 1.853341e-03 | 1 |
| GO:BP | GO:0031669 | cellular response to nutrient levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] | 9 | 1.913905e-03 | 1 |
| GO:BP | GO:0071478 | cellular response to radiation | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:mah] | 8 | 1.915886e-03 | 1 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 17 | 1.982525e-03 | 1 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 49 | 2.191074e-03 | 1 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 14 | 2.282052e-03 | 1 |
| GO:BP | GO:0006289 | nucleotide-excision repair | "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] | 6 | 2.678927e-03 | 1 |
| GO:BP | GO:0042149 | cellular response to glucose starvation | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose." [GOC:jl] | 5 | 2.815167e-03 | 1 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 16 | 2.841750e-03 | 1 |
| GO:BP | GO:0006970 | response to osmotic stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] | 6 | 2.875490e-03 | 1 |
| GO:BP | GO:0006402 | mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 9 | 2.923556e-03 | 1 |
| GO:BP | GO:0071396 | cellular response to lipid | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah] | 13 | 2.979744e-03 | 1 |
| GO:BP | GO:0104004 | cellular response to environmental stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus." [GOC:dos] | 10 | 3.011280e-03 | 1 |
| GO:BP | GO:0071214 | cellular response to abiotic stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah] | 10 | 3.011280e-03 | 1 |
| GO:BP | GO:0050684 | regulation of mRNA processing | "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] | 7 | 3.032069e-03 | 1 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 14 | 3.126895e-03 | 1 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 46 | 3.262031e-03 | 1 |
| GO:BP | GO:0007165 | signal transduction | "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] | 46 | 3.345959e-03 | 1 |
| GO:BP | GO:0061136 | regulation of proteasomal protein catabolic process | "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb] | 8 | 3.475042e-03 | 1 |
| GO:BP | GO:0006458 | 'de novo' protein folding | "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] | 5 | 3.493846e-03 | 1 |
| GO:BP | GO:0006397 | mRNA processing | "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] | 23 | 3.502936e-03 | 1 |
| GO:BP | GO:0002221 | pattern recognition receptor signaling pathway | "The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] | 9 | 3.526885e-03 | 1 |
| GO:BP | GO:0009314 | response to radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] | 11 | 4.061503e-03 | 1 |
| GO:BP | GO:0032388 | positive regulation of intracellular transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] | 7 | 4.066651e-03 | 1 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 12 | 4.182344e-03 | 1 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 8 | 4.191255e-03 | 1 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] | 13 | 4.633898e-03 | 1 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 14 | 4.661674e-03 | 1 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 12 | 4.787501e-03 | 1 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 6 | 4.912871e-03 | 1 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 12 | 5.167024e-03 | 1 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 17 | 5.173051e-03 | 1 |
| GO:BP | GO:0010332 | response to gamma radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators] | 5 | 5.234557e-03 | 1 |
| GO:BP | GO:0030520 | estrogen receptor signaling pathway | "A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] | 5 | 5.234557e-03 | 1 |
| GO:BP | GO:0034620 | cellular response to unfolded protein | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah] | 6 | 5.572858e-03 | 1 |
| GO:BP | GO:0051131 | chaperone-mediated protein complex assembly | "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai] | 4 | 5.928856e-03 | 1 |
| GO:BP | GO:0009651 | response to salt stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] | 4 | 5.928856e-03 | 1 |
| GO:BP | GO:0032212 | positive regulation of telomere maintenance via telomerase | "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 4 | 5.928856e-03 | 1 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 19 | 6.226337e-03 | 1 |
| GO:BP | GO:1903432 | regulation of TORC1 signaling | "Any process that modulates the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie] | 6 | 6.303391e-03 | 1 |
| GO:BP | GO:0010906 | regulation of glucose metabolic process | "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] | 6 | 6.303391e-03 | 1 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 7 | 6.441637e-03 | 1 |
| GO:BP | GO:0016567 | protein ubiquitination | "The process in which one or more ubiquitin groups are added to a protein." [PMID:26906419] | 14 | 6.636024e-03 | 1 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 39 | 6.743069e-03 | 1 |
| GO:BP | GO:0032784 | regulation of DNA-templated transcription elongation | "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] | 6 | 7.543907e-03 | 1 |
| GO:BP | GO:1903608 | protein localization to cytoplasmic stress granule | "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule." [GO_REF:0000087, GOC:TermGenie, PMID:24755092] | 3 | 8.206234e-03 | 1 |
| GO:BP | GO:0050793 | regulation of developmental process | "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] | 26 | 8.766324e-03 | 1 |
| GO:BP | GO:0040029 | epigenetic regulation of gene expression | "A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474] | 9 | 8.905314e-03 | 1 |
| GO:BP | GO:1903312 | negative regulation of mRNA metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 6 | 8.976290e-03 | 1 |
| GO:BP | GO:0050792 | regulation of viral process | "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:go_curators, GOC:tb] | 7 | 9.089886e-03 | 1 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 40 | 9.175517e-03 | 1 |
| GO:BP | GO:0038202 | TORC1 signaling | "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb] | 6 | 9.500132e-03 | 1 |
| GO:BP | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 4 | 9.699839e-03 | 1 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 23 | 1.042167e-02 | 1 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 6 | 1.062248e-02 | 1 |
| GO:BP | GO:0071168 | protein localization to chromatin | "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah] | 5 | 1.071795e-02 | 1 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah] | 13 | 1.072466e-02 | 1 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 8 | 1.096938e-02 | 1 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 7 | 1.162418e-02 | 1 |
| GO:BP | GO:0050807 | regulation of synapse organization | "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] | 9 | 1.162527e-02 | 1 |
| GO:BP | GO:2001234 | negative regulation of apoptotic signaling pathway | "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 8 | 1.169025e-02 | 1 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 15 | 1.225717e-02 | 1 |
| GO:BP | GO:0033993 | response to lipid | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] | 15 | 1.257912e-02 | 1 |
| GO:BP | GO:0035967 | cellular response to topologically incorrect protein | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] | 6 | 1.319098e-02 | 1 |
| GO:BP | GO:1903050 | regulation of proteolysis involved in protein catabolic process | "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] | 8 | 1.325298e-02 | 1 |
| GO:BP | GO:0006401 | RNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 9 | 1.357749e-02 | 1 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] | 9 | 1.392877e-02 | 1 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 9 | 1.465475e-02 | 1 |
| GO:BP | GO:1904357 | negative regulation of telomere maintenance via telomere lengthening | "Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 4 | 1.500392e-02 | 1 |
| GO:BP | GO:0051170 | import into nucleus | "The directed movement of substances into the nucleus." [GOC:ai] | 7 | 1.529842e-02 | 1 |
| GO:BP | GO:0062012 | regulation of small molecule metabolic process | "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] | 9 | 1.541295e-02 | 1 |
| GO:BP | GO:0048024 | regulation of mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 6 | 1.543069e-02 | 1 |
| GO:BP | GO:0046824 | positive regulation of nucleocytoplasmic transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] | 5 | 1.594868e-02 | 1 |
| GO:BP | GO:0042770 | signal transduction in response to DNA damage | "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators] | 7 | 1.650967e-02 | 1 |
| GO:BP | GO:0000077 | DNA damage checkpoint signaling | "A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah] | 6 | 1.708822e-02 | 1 |
| GO:BP | GO:0002753 | cytoplasmic pattern recognition receptor signaling pathway | "The series of molecular signals initiated by the binding of a ligand from another organism to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967, PMID:17328678, PMID:18272355, PMID:19531363, PMID:21187438] | 7 | 1.714454e-02 | 1 |
| GO:BP | GO:0051085 | chaperone cofactor-dependent protein refolding | "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb] | 4 | 1.717244e-02 | 1 |
| GO:BP | GO:0042256 | cytosolic ribosome assembly | "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol." [GOC:ma, PMID:30467428] | 3 | 1.747964e-02 | 1 |
| GO:BP | GO:0070848 | response to growth factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah] | 13 | 1.748242e-02 | 1 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 15 | 1.750976e-02 | 1 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 10 | 1.770970e-02 | 1 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] | 15 | 1.772983e-02 | 1 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 9 | 1.833752e-02 | 1 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 7 | 1.847523e-02 | 1 |
| GO:BP | GO:0141193 | nuclear receptor-mediated signaling pathway | "The series of molecular signals initiated by a signaling molecule binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [PMID:25614732] | 7 | 1.917207e-02 | 1 |
| GO:BP | GO:0062098 | regulation of programmed necrotic cell death | "Any process that modulates the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785] | 4 | 1.956382e-02 | 1 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] | 9 | 2.021287e-02 | 1 |
| GO:BP | GO:0006368 | transcription elongation by RNA polymerase II | "The extension of an RNA molecule after transcription pausing and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] | 6 | 2.083685e-02 | 1 |
| GO:BP | GO:0048255 | mRNA stabilization | "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid] | 5 | 2.142014e-02 | 1 |
| GO:BP | GO:0039531 | regulation of cytoplasmic pattern recognition receptor signaling pathway | "Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway." [GOC:bf, GOC:jl] | 6 | 2.187100e-02 | 1 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 42 | 2.188022e-02 | 1 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 12 | 2.265073e-02 | 1 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 10 | 2.317478e-02 | 1 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb] | 8 | 2.331636e-02 | 1 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 10 | 2.364977e-02 | 1 |
| GO:BP | GO:0070934 | CRD-mediated mRNA stabilization | "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303] | 3 | 2.396257e-02 | 1 |
| GO:BP | GO:0032355 | response to estradiol | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah, ISBN:0911910123] | 6 | 2.406406e-02 | 1 |
| GO:BP | GO:0030518 | nuclear receptor-mediated steroid hormone signaling pathway | "A nuclear receptor-mediated signaling pathway initiated by a steroid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] | 6 | 2.406406e-02 | 1 |
| GO:BP | GO:0006006 | glucose metabolic process | "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] | 7 | 2.468729e-02 | 1 |
| GO:BP | GO:0048545 | response to steroid hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators] | 9 | 2.504130e-02 | 1 |
| GO:BP | GO:0031570 | DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] | 6 | 2.643179e-02 | 1 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 12 | 2.652278e-02 | 1 |
| GO:BP | GO:0141188 | nucleic acid catabolic process | "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators] | 9 | 2.685564e-02 | 1 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906] | 11 | 2.725086e-02 | 1 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:22651914, PMID:28096268] | 9 | 2.748485e-02 | 1 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 12 | 2.866786e-02 | 1 |
| GO:BP | GO:0030098 | lymphocyte differentiation | "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators] | 10 | 3.123856e-02 | 1 |
| GO:BP | GO:0060218 | hematopoietic stem cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083] | 4 | 3.164504e-02 | 1 |
| GO:BP | GO:0032386 | regulation of intracellular transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] | 8 | 3.165390e-02 | 1 |
| GO:BP | GO:0000956 | nuclear-transcribed mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] | 6 | 3.173295e-02 | 1 |
| GO:BP | GO:1900152 | negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] | 3 | 3.185447e-02 | 1 |
| GO:BP | GO:0032481 | positive regulation of type I interferon production | "Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] | 5 | 3.226157e-02 | 1 |
| GO:BP | GO:0044093 | positive regulation of molecular function | "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 14 | 3.286535e-02 | 1 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] | 8 | 3.341148e-02 | 1 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 11 | 3.350276e-02 | 1 |
| GO:BP | GO:0009896 | positive regulation of catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 11 | 3.350276e-02 | 1 |
| GO:BP | GO:0023052 | signaling | "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] | 46 | 3.776239e-02 | 1 |
| GO:BP | GO:0043489 | RNA stabilization | "Prevention of degradation of RNA molecules." [GOC:go_curators] | 5 | 3.907916e-02 | 1 |
| GO:BP | GO:0061013 | regulation of mRNA catabolic process | "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 7 | 3.969747e-02 | 1 |
| GO:BP | GO:0031571 | mitotic G1 DNA damage checkpoint signaling | "A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle] | 3 | 4.128690e-02 | 1 |
| GO:BP | GO:1902373 | negative regulation of mRNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865] | 5 | 4.158457e-02 | 1 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 22 | 4.164364e-02 | 1 |
| GO:BP | GO:0007154 | cell communication | "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] | 46 | 4.212372e-02 | 1 |
| GO:BP | GO:0007178 | cell surface receptor protein serine/threonine kinase signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] | 9 | 4.299354e-02 | 1 |
| GO:BP | GO:0006354 | DNA-templated transcription elongation | "The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161] | 6 | 4.305812e-02 | 1 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 13 | 4.362418e-02 | 1 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 14 | 4.373551e-02 | 1 |
| GO:BP | GO:0032205 | negative regulation of telomere maintenance | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 4 | 4.377092e-02 | 1 |
| GO:BP | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] | 4 | 4.377092e-02 | 1 |
| GO:BP | GO:0070266 | necroptotic process | "A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former." [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153] | 4 | 4.848124e-02 | 1 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 55 | 1.565225e-21 | 1 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 68 | 1.100617e-20 | 1 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 22 | 1.889759e-18 | 1 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 24 | 3.169722e-18 | 1 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 22 | 6.565225e-18 | 1 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 25 | 3.908955e-15 | 1 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 33 | 7.235329e-15 | 1 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 25 | 1.135008e-14 | 1 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 40 | 1.226684e-14 | 1 |
| GO:MF | GO:0120545 | nucleic acid conformation isomerase activity | "Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-] | 15 | 2.691166e-13 | 1 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 23 | 8.692926e-13 | 1 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 40 | 7.881942e-12 | 1 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 18 | 2.398588e-11 | 1 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 28 | 2.679229e-11 | 1 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 16 | 4.792786e-11 | 1 |
| GO:MF | GO:0004386 | helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] | 13 | 7.916556e-11 | 1 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 28 | 8.908684e-11 | 1 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 28 | 9.083690e-11 | 1 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 28 | 9.083690e-11 | 1 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 31 | 2.633815e-10 | 1 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 35 | 9.996770e-10 | 1 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 29 | 1.216368e-09 | 1 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 36 | 1.469579e-09 | 1 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 36 | 1.832353e-09 | 1 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 29 | 2.388678e-09 | 1 |
| GO:MF | GO:0016853 | isomerase activity | "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] | 17 | 3.608911e-09 | 1 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 33 | 4.098482e-09 | 1 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 33 | 8.856488e-09 | 1 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 36 | 8.892887e-09 | 1 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 33 | 1.096331e-08 | 1 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 25 | 1.221076e-08 | 1 |
| GO:MF | GO:0003684 | damaged DNA binding | "Binding to damaged DNA." [GOC:jl] | 9 | 1.787442e-08 | 1 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 23 | 2.080234e-08 | 1 |
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 7 | 2.483588e-08 | 1 |
| GO:MF | GO:0003727 | single-stranded RNA binding | "Binding to single-stranded RNA." [GOC:jl] | 9 | 5.006594e-08 | 1 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 10 | 5.704674e-08 | 1 |
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 10 | 6.707479e-08 | 1 |
| GO:MF | GO:0003678 | DNA helicase activity | "Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl] | 8 | 7.534821e-08 | 1 |
| GO:MF | GO:0042162 | telomeric DNA binding | "Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624] | 7 | 1.163410e-07 | 1 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 86 | 1.324765e-07 | 1 |
| GO:MF | GO:0003712 | transcription coregulator activity | "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] | 16 | 1.326413e-07 | 1 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 35 | 1.673723e-07 | 1 |
| GO:MF | GO:0003724 | RNA helicase activity | "Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098] | 8 | 6.039480e-07 | 1 |
| GO:MF | GO:0003730 | mRNA 3'-UTR binding | "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] | 9 | 7.125613e-07 | 1 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 33 | 7.256513e-07 | 1 |
| GO:MF | GO:0008186 | ATP-dependent activity, acting on RNA | "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl] | 8 | 7.457936e-07 | 1 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 13 | 9.134919e-07 | 1 |
| GO:MF | GO:0097718 | disordered domain specific binding | "Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698] | 6 | 1.125711e-06 | 1 |
| GO:MF | GO:0043021 | ribonucleoprotein complex binding | "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] | 10 | 1.861253e-06 | 1 |
| GO:MF | GO:0042826 | histone deacetylase binding | "Binding to histone deacetylase." [GOC:jl] | 9 | 1.862141e-06 | 1 |
| GO:MF | GO:0140640 | catalytic activity, acting on a nucleic acid | "Catalytic activity that acts to modify a nucleic acid." [GOC:pg] | 16 | 6.586802e-06 | 1 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 29 | 6.830730e-06 | 1 |
| GO:MF | GO:0140097 | catalytic activity, acting on DNA | "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] | 11 | 7.286192e-06 | 1 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 7 | 8.055113e-06 | 1 |
| GO:MF | GO:0003725 | double-stranded RNA binding | "Binding to double-stranded RNA." [GOC:jl] | 7 | 1.330594e-05 | 1 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 8 | 1.441229e-05 | 1 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 54 | 2.635313e-05 | 1 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 24 | 3.669751e-05 | 1 |
| GO:MF | GO:0003713 | transcription coactivator activity | "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 10 | 6.493333e-05 | 1 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 52 | 7.250824e-05 | 1 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 51 | 7.606570e-05 | 1 |
| GO:MF | GO:0001099 | basal RNA polymerase II transcription machinery binding | "Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] | 6 | 1.066670e-04 | 1 |
| GO:MF | GO:0001098 | basal transcription machinery binding | "Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] | 6 | 1.066670e-04 | 1 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 14 | 1.217219e-04 | 1 |
| GO:MF | GO:0098847 | sequence-specific single stranded DNA binding | "Binding to single-stranded DNA of a specific nucleotide composition." [PMID:9531483] | 4 | 1.495516e-04 | 1 |
| GO:MF | GO:1990841 | promoter-specific chromatin binding | "Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729] | 6 | 2.268909e-04 | 1 |
| GO:MF | GO:0002039 | p53 binding | "Binding to one of the p53 family of proteins." [GOC:hjd] | 6 | 2.476487e-04 | 1 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 13 | 3.993465e-04 | 1 |
| GO:MF | GO:0031072 | heat shock protein binding | "Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw] | 7 | 7.456543e-04 | 1 |
| GO:MF | GO:0016787 | hydrolase activity | "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] | 32 | 1.086007e-03 | 1 |
| GO:MF | GO:0030235 | nitric-oxide synthase regulator activity | "Binds to and modulates the activity of nitric oxide synthase." [GOC:mah] | 3 | 1.286088e-03 | 1 |
| GO:MF | GO:0019903 | protein phosphatase binding | "Binding to a protein phosphatase." [GOC:jl] | 7 | 1.469362e-03 | 1 |
| GO:MF | GO:0001091 | RNA polymerase II general transcription initiation factor binding | "Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:txnOH, PMID:16858867] | 4 | 1.536305e-03 | 1 |
| GO:MF | GO:0023026 | MHC class II protein complex binding | "Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw] | 4 | 1.536305e-03 | 1 |
| GO:MF | GO:0031490 | chromatin DNA binding | "Binding to DNA that is assembled into chromatin." [GOC:mah] | 7 | 1.840109e-03 | 1 |
| GO:MF | GO:0008143 | poly(A) binding | "Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl] | 4 | 2.512537e-03 | 1 |
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 23 | 2.724168e-03 | 1 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 14 | 3.438807e-03 | 1 |
| GO:MF | GO:0001094 | TFIID-class transcription factor complex binding | "Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] | 3 | 4.368438e-03 | 1 |
| GO:MF | GO:0004517 | nitric-oxide synthase activity | "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, RHEA:19897] | 3 | 4.368438e-03 | 1 |
| GO:MF | GO:0098505 | G-rich strand telomeric DNA binding | "Binding to G-rich, single-stranded, telomere-associated DNA." [PMID:11349150] | 3 | 4.368438e-03 | 1 |
| GO:MF | GO:0070717 | poly-purine tract binding | "Binding to a stretch of purines (adenine or guanine) in an RNA molecule." [GOC:mah] | 4 | 5.064513e-03 | 1 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 13 | 5.492147e-03 | 1 |
| GO:MF | GO:0023023 | MHC protein complex binding | "Binding to a major histocompatibility complex." [GOC:mtg_signal, GOC:vw] | 4 | 5.744213e-03 | 1 |
| GO:MF | GO:0043047 | single-stranded telomeric DNA binding | "Binding to single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] | 3 | 7.959093e-03 | 1 |
| GO:MF | GO:0019902 | phosphatase binding | "Binding to a phosphatase." [GOC:jl] | 7 | 8.939088e-03 | 1 |
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 9 | 9.049228e-03 | 1 |
| GO:MF | GO:0051087 | protein-folding chaperone binding | "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443] | 6 | 1.186837e-02 | 1 |
| GO:MF | GO:0003688 | DNA replication origin binding | "Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators] | 3 | 1.308697e-02 | 1 |
| GO:MF | GO:0001046 | core promoter sequence-specific DNA binding | "Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH] | 4 | 1.525599e-02 | 1 |
| GO:MF | GO:0048156 | tau protein binding | "Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] | 4 | 1.676574e-02 | 1 |
| GO:MF | GO:0044325 | transmembrane transporter binding | "Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372] | 6 | 1.712177e-02 | 1 |
| GO:MF | GO:0035613 | RNA stem-loop binding | "Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544] | 3 | 2.000892e-02 | 1 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 10 | 2.228938e-02 | 1 |
| GO:MF | GO:0045027 | DNA end binding | "Binding to DNA ends exposed by the creation of double-strand breaks (DSBs)." [GOC:jl] | 2 | 2.650924e-02 | 1 |
| GO:MF | GO:0140098 | catalytic activity, acting on RNA | "Catalytic activity that acts to modify RNA." [GOC:molecular_function_refactoring, GOC:pdt] | 9 | 3.301519e-02 | 1 |
| GO:MF | GO:0031491 | nucleosome binding | "Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah] | 5 | 3.459563e-02 | 1 |
| GO:MF | GO:0140296 | general transcription initiation factor binding | "Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation." [GOC:txnOH-2018] | 4 | 3.850101e-02 | 1 |
| GO:MF | GO:0043531 | ADP binding | "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl] | 4 | 3.850101e-02 | 1 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 37 | 2.367015e-21 | 1 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 39 | 2.521136e-21 | 1 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 38 | 6.420136e-21 | 1 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 38 | 8.137878e-21 | 1 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 36 | 1.068221e-20 | 1 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 37 | 1.242400e-20 | 1 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 25 | 3.674205e-20 | 1 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 35 | 4.048901e-20 | 1 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 35 | 4.493248e-20 | 1 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 34 | 4.615408e-20 | 1 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 35 | 6.450661e-20 | 1 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 39 | 9.438968e-20 | 1 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 36 | 2.253939e-19 | 1 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 40 | 3.309748e-19 | 1 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 44 | 4.661745e-19 | 1 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 23 | 5.400421e-19 | 1 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 37 | 6.430665e-19 | 1 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 40 | 8.234877e-19 | 1 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 32 | 1.269147e-18 | 1 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 35 | 1.454113e-18 | 1 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 32 | 1.664996e-18 | 1 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 24 | 1.756621e-18 | 1 |
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 34 | 1.777215e-18 | 1 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 23 | 1.793996e-18 | 1 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 38 | 2.060074e-18 | 1 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 35 | 2.196900e-18 | 1 |
| HPA | HPA:0471492 | Skin 2; vascular mural cells[≥Medium] | Skin 2; vascular mural cells[≥Medium] | 22 | 2.304070e-18 | 1 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 32 | 3.159718e-18 | 1 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 37 | 3.298613e-18 | 1 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 32 | 3.699892e-18 | 1 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 25 | 6.755229e-18 | 1 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 24 | 9.333095e-18 | 1 |
| HPA | HPA:0471493 | Skin 2; vascular mural cells[High] | Skin 2; vascular mural cells[High] | 19 | 1.059311e-17 | 1 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 30 | 1.274531e-17 | 1 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 37 | 1.617120e-17 | 1 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 34 | 1.801554e-17 | 1 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 23 | 1.980544e-17 | 1 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 23 | 3.464651e-17 | 1 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 23 | 3.464651e-17 | 1 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 46 | 4.051515e-17 | 1 |
| HPA | HPA:0461393 | Skin 1; cells in basal layer[High] | Skin 1; cells in basal layer[High] | 21 | 4.766556e-17 | 1 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 37 | 6.795722e-17 | 1 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 32 | 6.920334e-17 | 1 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 31 | 9.535922e-17 | 1 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 44 | 3.434472e-16 | 1 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 51 | 4.770482e-16 | 1 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 40 | 1.327865e-15 | 1 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 35 | 1.728812e-15 | 1 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 37 | 2.338728e-15 | 1 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 37 | 3.800921e-15 | 1 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 25 | 6.837755e-15 | 1 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 24 | 8.469141e-15 | 1 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 61 | 9.894211e-15 | 1 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 31 | 1.085334e-14 | 1 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 35 | 1.629257e-14 | 1 |
| HPA | HPA:0461492 | Skin 1; vascular mural cells[≥Medium] | Skin 1; vascular mural cells[≥Medium] | 19 | 1.713557e-14 | 1 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 26 | 1.790800e-14 | 1 |
| HPA | HPA:0461493 | Skin 1; vascular mural cells[High] | Skin 1; vascular mural cells[High] | 17 | 1.870069e-14 | 1 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 37 | 2.107282e-14 | 1 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 33 | 2.136383e-14 | 1 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 22 | 2.306592e-14 | 1 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 62 | 4.160248e-14 | 1 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 32 | 5.498012e-14 | 1 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 46 | 7.779427e-14 | 1 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 22 | 1.144232e-13 | 1 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 33 | 1.382919e-13 | 1 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 22 | 1.491727e-13 | 1 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 24 | 1.792091e-13 | 1 |
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 23 | 4.136930e-13 | 1 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 65 | 4.378999e-13 | 1 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 45 | 4.471711e-13 | 1 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 39 | 4.911873e-13 | 1 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 47 | 5.734743e-13 | 1 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 49 | 6.490037e-13 | 1 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 36 | 6.570772e-13 | 1 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 52 | 1.143248e-12 | 1 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 44 | 1.224665e-12 | 1 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 54 | 1.280180e-12 | 1 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 40 | 1.281680e-12 | 1 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 28 | 1.312799e-12 | 1 |
| HPA | HPA:0170253 | Endometrium 2; cells in endometrial stroma[High] | Endometrium 2; cells in endometrial stroma[High] | 22 | 1.560850e-12 | 1 |
| HPA | HPA:0050093 | Breast; myoepithelial cells[High] | Breast; myoepithelial cells[High] | 31 | 1.701338e-12 | 1 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 42 | 1.979174e-12 | 1 |
| HPA | HPA:0390053 | Prostate; glandular cells[High] | Prostate; glandular cells[High] | 38 | 2.280792e-12 | 1 |
| HPA | HPA:0080123 | Caudate; glial cells[High] | Caudate; glial cells[High] | 28 | 4.584453e-12 | 1 |
| HPA | HPA:0291162 | Liver; cholangiocytes[≥Medium] | Liver; cholangiocytes[≥Medium] | 45 | 4.893255e-12 | 1 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 63 | 5.277331e-12 | 1 |
| HPA | HPA:0090183 | Cerebellum; cells in granular layer[High] | Cerebellum; cells in granular layer[High] | 29 | 6.990437e-12 | 1 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 70 | 7.010672e-12 | 1 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 39 | 8.948888e-12 | 1 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 45 | 1.111390e-11 | 1 |
| HPA | HPA:0570793 | Testis; round or early spermatids[High] | Testis; round or early spermatids[High] | 33 | 1.115018e-11 | 1 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 37 | 1.437818e-11 | 1 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 25 | 1.827528e-11 | 1 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 50 | 2.206251e-11 | 1 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 42 | 3.155496e-11 | 1 |
| HPA | HPA:0351183 | Pancreas; pancreatic endocrine cells[High] | Pancreas; pancreatic endocrine cells[High] | 29 | 3.305141e-11 | 1 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 23 | 3.663394e-11 | 1 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 28 | 3.881553e-11 | 1 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 51 | 4.075342e-11 | 1 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 79 | 4.784481e-11 | 1 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 40 | 7.655246e-11 | 1 |
| HPA | HPA:0160253 | Endometrium 1; cells in endometrial stroma[High] | Endometrium 1; cells in endometrial stroma[High] | 22 | 8.485454e-11 | 1 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 68 | 8.671213e-11 | 1 |
| HPA | HPA:0500653 | Soft tissue 1; fibroblasts[High] | Soft tissue 1; fibroblasts[High] | 24 | 9.467315e-11 | 1 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 64 | 1.043212e-10 | 1 |
| HPA | HPA:0500702 | Soft tissue 1; peripheral nerve[≥Medium] | Soft tissue 1; peripheral nerve[≥Medium] | 36 | 1.299767e-10 | 1 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 62 | 1.379682e-10 | 1 |
| HPA | HPA:0270353 | Kidney; cells in glomeruli[High] | Kidney; cells in glomeruli[High] | 29 | 1.585641e-10 | 1 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 72 | 1.967026e-10 | 1 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 77 | 2.720649e-10 | 1 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 33 | 2.744847e-10 | 1 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 34 | 2.790245e-10 | 1 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 30 | 2.978830e-10 | 1 |
| HPA | HPA:0570792 | Testis; round or early spermatids[≥Medium] | Testis; round or early spermatids[≥Medium] | 42 | 3.392230e-10 | 1 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 53 | 4.323953e-10 | 1 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 67 | 4.324515e-10 | 1 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 46 | 4.735845e-10 | 1 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 63 | 4.799909e-10 | 1 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 34 | 5.446633e-10 | 1 |
| HPA | HPA:0340000 | Ovary | Ovary | 70 | 5.630348e-10 | 1 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 73 | 7.109488e-10 | 1 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 58 | 7.130230e-10 | 1 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 77 | 7.330713e-10 | 1 |
| HPA | HPA:0570802 | Testis; sertoli cells[≥Medium] | Testis; sertoli cells[≥Medium] | 41 | 7.581319e-10 | 1 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 67 | 8.856078e-10 | 1 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 62 | 9.554728e-10 | 1 |
| HPA | HPA:0570771 | Testis; peritubular cells[≥Low] | Testis; peritubular cells[≥Low] | 26 | 1.058244e-09 | 1 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 61 | 1.243907e-09 | 1 |
| HPA | HPA:0570762 | Testis; pachytene spermatocytes[≥Medium] | Testis; pachytene spermatocytes[≥Medium] | 41 | 1.387398e-09 | 1 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 45 | 1.408816e-09 | 1 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 74 | 1.552455e-09 | 1 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 74 | 1.552455e-09 | 1 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 36 | 1.712542e-09 | 1 |
| HPA | HPA:0490693 | Smooth muscle; smooth muscle cells[High] | Smooth muscle; smooth muscle cells[High] | 24 | 1.836468e-09 | 1 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 77 | 2.044870e-09 | 1 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 36 | 2.052389e-09 | 1 |
| HPA | HPA:0010013 | Adipose tissue; adipocytes[High] | Adipose tissue; adipocytes[High] | 21 | 2.213633e-09 | 1 |
| HPA | HPA:0630053 | Cervix; glandular cells[High] | Cervix; glandular cells[High] | 32 | 3.036001e-09 | 1 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 31 | 3.059087e-09 | 1 |
| HPA | HPA:0510653 | Soft tissue 2; fibroblasts[High] | Soft tissue 2; fibroblasts[High] | 22 | 3.105154e-09 | 1 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 72 | 3.498585e-09 | 1 |
| HPA | HPA:0570772 | Testis; peritubular cells[≥Medium] | Testis; peritubular cells[≥Medium] | 22 | 3.746114e-09 | 1 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 69 | 4.250235e-09 | 1 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 68 | 4.694455e-09 | 1 |
| HPA | HPA:0570761 | Testis; pachytene spermatocytes[≥Low] | Testis; pachytene spermatocytes[≥Low] | 45 | 4.880267e-09 | 1 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 40 | 4.948483e-09 | 1 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 32 | 5.931223e-09 | 1 |
| HPA | HPA:0530723 | Spleen; cells in white pulp[High] | Spleen; cells in white pulp[High] | 27 | 6.143802e-09 | 1 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 65 | 8.626184e-09 | 1 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 78 | 8.707378e-09 | 1 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 78 | 8.707378e-09 | 1 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 35 | 8.769094e-09 | 1 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 66 | 1.013800e-08 | 1 |
| HPA | HPA:0060103 | Bronchus; respiratory epithelial cells[High] | Bronchus; respiratory epithelial cells[High] | 39 | 1.015097e-08 | 1 |
| HPA | HPA:0130242 | Colon; peripheral nerve/ganglion[≥Medium] | Colon; peripheral nerve/ganglion[≥Medium] | 54 | 1.130434e-08 | 1 |
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 58 | 1.636449e-08 | 1 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 50 | 1.660327e-08 | 1 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 74 | 1.827138e-08 | 1 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 74 | 1.827138e-08 | 1 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 56 | 2.165843e-08 | 1 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 69 | 2.451380e-08 | 1 |
| HPA | HPA:0461451 | Skin 1; hair follicles[≥Low] | Skin 1; hair follicles[≥Low] | 18 | 2.821801e-08 | 1 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 62 | 3.488358e-08 | 1 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 47 | 3.857577e-08 | 1 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 61 | 4.275936e-08 | 1 |
| HPA | HPA:0130243 | Colon; peripheral nerve/ganglion[High] | Colon; peripheral nerve/ganglion[High] | 26 | 4.363047e-08 | 1 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 77 | 5.129787e-08 | 1 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 72 | 5.247520e-08 | 1 |
| HPA | HPA:0570791 | Testis; round or early spermatids[≥Low] | Testis; round or early spermatids[≥Low] | 43 | 5.555824e-08 | 1 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 57 | 5.578646e-08 | 1 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 57 | 5.578646e-08 | 1 |
| HPA | HPA:0050012 | Breast; adipocytes[≥Medium] | Breast; adipocytes[≥Medium] | 34 | 6.080355e-08 | 1 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 59 | 7.000876e-08 | 1 |
| HPA | HPA:0461452 | Skin 1; hair follicles[≥Medium] | Skin 1; hair follicles[≥Medium] | 16 | 7.333999e-08 | 1 |
| HPA | HPA:0440343 | Skeletal muscle; myocytes[High] | Skeletal muscle; myocytes[High] | 26 | 7.421781e-08 | 1 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 44 | 7.826830e-08 | 1 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 74 | 7.967632e-08 | 1 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 47 | 8.324652e-08 | 1 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 65 | 8.391509e-08 | 1 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 63 | 8.485168e-08 | 1 |
| HPA | HPA:0490692 | Smooth muscle; smooth muscle cells[≥Medium] | Smooth muscle; smooth muscle cells[≥Medium] | 50 | 9.246360e-08 | 1 |
| HPA | HPA:0570783 | Testis; preleptotene spermatocytes[High] | Testis; preleptotene spermatocytes[High] | 24 | 9.919763e-08 | 1 |
| HPA | HPA:0500701 | Soft tissue 1; peripheral nerve[≥Low] | Soft tissue 1; peripheral nerve[≥Low] | 47 | 1.011958e-07 | 1 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 60 | 1.132587e-07 | 1 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 54 | 1.174732e-07 | 1 |
| HPA | HPA:0570773 | Testis; peritubular cells[High] | Testis; peritubular cells[High] | 14 | 1.226442e-07 | 1 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 77 | 1.265546e-07 | 1 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 77 | 1.265546e-07 | 1 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 65 | 1.378786e-07 | 1 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 65 | 1.586913e-07 | 1 |
| HPA | HPA:0630000 | Cervix | Cervix | 75 | 1.589154e-07 | 1 |
| HPA | HPA:0510652 | Soft tissue 2; fibroblasts[≥Medium] | Soft tissue 2; fibroblasts[≥Medium] | 45 | 1.728893e-07 | 1 |
| HPA | HPA:0090163 | Cerebellum; Purkinje cells[High] | Cerebellum; Purkinje cells[High] | 34 | 1.775865e-07 | 1 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 66 | 1.869108e-07 | 1 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 75 | 1.884831e-07 | 1 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 70 | 1.910041e-07 | 1 |
| HPA | HPA:0620000 | Vagina | Vagina | 70 | 1.910041e-07 | 1 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 58 | 2.299191e-07 | 1 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 53 | 3.035933e-07 | 1 |
| HPA | HPA:0600443 | Tonsil; non-germinal center cells[High] | Tonsil; non-germinal center cells[High] | 31 | 3.046137e-07 | 1 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 73 | 3.581409e-07 | 1 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 74 | 3.712695e-07 | 1 |
| HPA | HPA:0530000 | Spleen | Spleen | 69 | 3.759731e-07 | 1 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 56 | 3.939151e-07 | 1 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 57 | 3.985133e-07 | 1 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 77 | 4.383802e-07 | 1 |
| HPA | HPA:0400000 | Rectum | Rectum | 79 | 4.663057e-07 | 1 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 70 | 6.191420e-07 | 1 |
| HPA | HPA:0570781 | Testis; preleptotene spermatocytes[≥Low] | Testis; preleptotene spermatocytes[≥Low] | 37 | 6.213907e-07 | 1 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 73 | 6.554899e-07 | 1 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 73 | 6.554899e-07 | 1 |
| HPA | HPA:0380000 | Placenta | Placenta | 77 | 6.712182e-07 | 1 |
| HPA | HPA:0300413 | Lung; macrophages[High] | Lung; macrophages[High] | 31 | 7.199261e-07 | 1 |
| HPA | HPA:0360053 | Parathyroid gland; glandular cells[High] | Parathyroid gland; glandular cells[High] | 33 | 8.041446e-07 | 1 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 73 | 8.718373e-07 | 1 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 42 | 9.285830e-07 | 1 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 78 | 9.354165e-07 | 1 |
| HPA | HPA:0270352 | Kidney; cells in glomeruli[≥Medium] | Kidney; cells in glomeruli[≥Medium] | 48 | 9.410334e-07 | 1 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 71 | 9.648026e-07 | 1 |
| HPA | HPA:0010012 | Adipose tissue; adipocytes[≥Medium] | Adipose tissue; adipocytes[≥Medium] | 40 | 1.096519e-06 | 1 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 60 | 1.124125e-06 | 1 |
| HPA | HPA:0570782 | Testis; preleptotene spermatocytes[≥Medium] | Testis; preleptotene spermatocytes[≥Medium] | 32 | 1.278470e-06 | 1 |
| HPA | HPA:0130203 | Colon; endothelial cells[High] | Colon; endothelial cells[High] | 24 | 1.311287e-06 | 1 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 14 | 1.425207e-06 | 1 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 56 | 1.485263e-06 | 1 |
| HPA | HPA:0080000 | Caudate | Caudate | 74 | 1.514074e-06 | 1 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 60 | 1.729620e-06 | 1 |
| HPA | HPA:0050000 | Breast | Breast | 75 | 1.745172e-06 | 1 |
| HPA | HPA:0530712 | Spleen; cells in red pulp[≥Medium] | Spleen; cells in red pulp[≥Medium] | 48 | 1.852837e-06 | 1 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 76 | 1.899741e-06 | 1 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 76 | 2.005157e-06 | 1 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 75 | 2.033486e-06 | 1 |
| HPA | HPA:0090182 | Cerebellum; cells in granular layer[≥Medium] | Cerebellum; cells in granular layer[≥Medium] | 46 | 2.069582e-06 | 1 |
| HPA | HPA:0570803 | Testis; sertoli cells[High] | Testis; sertoli cells[High] | 20 | 2.092113e-06 | 1 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 61 | 2.116601e-06 | 1 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 76 | 2.135387e-06 | 1 |
| HPA | HPA:0381192 | Placenta; cytotrophoblasts[≥Medium] | Placenta; cytotrophoblasts[≥Medium] | 17 | 2.144483e-06 | 1 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 65 | 2.349785e-06 | 1 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 65 | 2.349785e-06 | 1 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 78 | 2.547229e-06 | 1 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 73 | 2.558907e-06 | 1 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 70 | 2.584681e-06 | 1 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 74 | 2.786819e-06 | 1 |
| HPA | HPA:0530713 | Spleen; cells in red pulp[High] | Spleen; cells in red pulp[High] | 23 | 3.185602e-06 | 1 |
| HPA | HPA:0220053 | Gallbladder; glandular cells[High] | Gallbladder; glandular cells[High] | 45 | 3.882857e-06 | 1 |
| HPA | HPA:0131333 | Colon; mucosal lymphoid cells[High] | Colon; mucosal lymphoid cells[High] | 11 | 4.105131e-06 | 1 |
| HPA | HPA:0461453 | Skin 1; hair follicles[High] | Skin 1; hair follicles[High] | 10 | 4.555441e-06 | 1 |
| HPA | HPA:0500703 | Soft tissue 1; peripheral nerve[High] | Soft tissue 1; peripheral nerve[High] | 13 | 4.717662e-06 | 1 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 71 | 4.830419e-06 | 1 |
| HPA | HPA:0380203 | Placenta; endothelial cells[High] | Placenta; endothelial cells[High] | 13 | 5.467128e-06 | 1 |
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 36 | 5.857119e-06 | 1 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 55 | 6.084850e-06 | 1 |
| HPA | HPA:0241103 | Heart muscle; cardiomyocytes[High] | Heart muscle; cardiomyocytes[High] | 27 | 7.987709e-06 | 1 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 52 | 8.471763e-06 | 1 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 54 | 9.092316e-06 | 1 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 43 | 9.502185e-06 | 1 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 54 | 1.011816e-05 | 1 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 76 | 1.120878e-05 | 1 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 76 | 1.120878e-05 | 1 |
| HPA | HPA:0030000 | Appendix | Appendix | 77 | 1.148762e-05 | 1 |
| HPA | HPA:0381191 | Placenta; cytotrophoblasts[≥Low] | Placenta; cytotrophoblasts[≥Low] | 17 | 1.182104e-05 | 1 |
| HPA | HPA:0050013 | Breast; adipocytes[High] | Breast; adipocytes[High] | 14 | 1.202075e-05 | 1 |
| HPA | HPA:0510702 | Soft tissue 2; peripheral nerve[≥Medium] | Soft tissue 2; peripheral nerve[≥Medium] | 31 | 1.231212e-05 | 1 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 11 | 1.520086e-05 | 1 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 62 | 1.563051e-05 | 1 |
| HPA | HPA:0130202 | Colon; endothelial cells[≥Medium] | Colon; endothelial cells[≥Medium] | 51 | 1.600345e-05 | 1 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 63 | 1.720468e-05 | 1 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 55 | 1.728800e-05 | 1 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 76 | 1.739087e-05 | 1 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 76 | 1.739087e-05 | 1 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 68 | 1.795811e-05 | 1 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 76 | 1.799704e-05 | 1 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 76 | 1.799704e-05 | 1 |
| HPA | HPA:0291163 | Liver; cholangiocytes[High] | Liver; cholangiocytes[High] | 14 | 1.929582e-05 | 1 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 62 | 2.035449e-05 | 1 |
| HPA | HPA:0400652 | Rectum; fibroblasts[≥Medium] | Rectum; fibroblasts[≥Medium] | 9 | 2.126192e-05 | 1 |
| HPA | HPA:0131302 | Colon; enterocytes[≥Medium] | Colon; enterocytes[≥Medium] | 15 | 2.235084e-05 | 1 |
| HPA | HPA:0400202 | Rectum; endothelial cells[≥Medium] | Rectum; endothelial cells[≥Medium] | 11 | 2.391279e-05 | 1 |
| HPA | HPA:0090181 | Cerebellum; cells in granular layer[≥Low] | Cerebellum; cells in granular layer[≥Low] | 57 | 2.483232e-05 | 1 |
| HPA | HPA:0090161 | Cerebellum; Purkinje cells[≥Low] | Cerebellum; Purkinje cells[≥Low] | 64 | 2.769041e-05 | 1 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 15 | 2.837027e-05 | 1 |
| HPA | HPA:0381203 | Placenta; hofbauer cells[High] | Placenta; hofbauer cells[High] | 13 | 3.005006e-05 | 1 |
| HPA | HPA:0500111 | Soft tissue 1; chondrocytes[≥Low] | Soft tissue 1; chondrocytes[≥Low] | 37 | 3.022269e-05 | 1 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 14 | 3.149077e-05 | 1 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 67 | 3.159342e-05 | 1 |
| HPA | HPA:0440342 | Skeletal muscle; myocytes[≥Medium] | Skeletal muscle; myocytes[≥Medium] | 51 | 3.253592e-05 | 1 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 62 | 3.700699e-05 | 1 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 59 | 3.843477e-05 | 1 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 58 | 4.356154e-05 | 1 |
| HPA | HPA:0510703 | Soft tissue 2; peripheral nerve[High] | Soft tissue 2; peripheral nerve[High] | 13 | 4.683705e-05 | 1 |
| HPA | HPA:0381193 | Placenta; cytotrophoblasts[High] | Placenta; cytotrophoblasts[High] | 13 | 5.066658e-05 | 1 |
| HPA | HPA:0380523 | Placenta; trophoblastic cells[High] | Placenta; trophoblastic cells[High] | 34 | 5.551949e-05 | 1 |
| HPA | HPA:0461481 | Skin 1; sebaceous glands[≥Low] | Skin 1; sebaceous glands[≥Low] | 11 | 5.838702e-05 | 1 |
| HPA | HPA:0400651 | Rectum; fibroblasts[≥Low] | Rectum; fibroblasts[≥Low] | 9 | 6.101937e-05 | 1 |
| HPA | HPA:0340452 | Ovary; follicle cells[≥Medium] | Ovary; follicle cells[≥Medium] | 37 | 6.369334e-05 | 1 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 70 | 7.323512e-05 | 1 |
| HPA | HPA:0390000 | Prostate | Prostate | 70 | 7.323512e-05 | 1 |
| HPA | HPA:0270363 | Kidney; cells in tubules[High] | Kidney; cells in tubules[High] | 36 | 7.505720e-05 | 1 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 64 | 7.527087e-05 | 1 |
| HPA | HPA:0030433 | Appendix; germinal center cells[High] | Appendix; germinal center cells[High] | 8 | 7.642315e-05 | 1 |
| HPA | HPA:0461482 | Skin 1; sebaceous glands[≥Medium] | Skin 1; sebaceous glands[≥Medium] | 10 | 7.998403e-05 | 1 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 66 | 8.027488e-05 | 1 |
| HPA | HPA:0031302 | Appendix; enterocytes[≥Medium] | Appendix; enterocytes[≥Medium] | 14 | 8.133309e-05 | 1 |
| HPA | HPA:0400893 | Rectum; goblet cells[High] | Rectum; goblet cells[High] | 11 | 9.490306e-05 | 1 |
| HPA | HPA:0340453 | Ovary; follicle cells[High] | Ovary; follicle cells[High] | 18 | 1.014262e-04 | 1 |
| HPA | HPA:0030892 | Appendix; goblet cells[≥Medium] | Appendix; goblet cells[≥Medium] | 13 | 1.037443e-04 | 1 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 71 | 1.086934e-04 | 1 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 71 | 1.086934e-04 | 1 |
| HPA | HPA:0030073 | Appendix; lymphoid tissue[High] | Appendix; lymphoid tissue[High] | 20 | 1.089215e-04 | 1 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 76 | 1.090226e-04 | 1 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 65 | 1.090276e-04 | 1 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 65 | 1.090276e-04 | 1 |
| HPA | HPA:0131303 | Colon; enterocytes[High] | Colon; enterocytes[High] | 11 | 1.198130e-04 | 1 |
| HPA | HPA:0381201 | Placenta; hofbauer cells[≥Low] | Placenta; hofbauer cells[≥Low] | 15 | 1.317920e-04 | 1 |
| HPA | HPA:0381202 | Placenta; hofbauer cells[≥Medium] | Placenta; hofbauer cells[≥Medium] | 14 | 1.509375e-04 | 1 |
| HPA | HPA:0130241 | Colon; peripheral nerve/ganglion[≥Low] | Colon; peripheral nerve/ganglion[≥Low] | 59 | 1.548676e-04 | 1 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 58 | 1.776044e-04 | 1 |
| HPA | HPA:0400203 | Rectum; endothelial cells[High] | Rectum; endothelial cells[High] | 8 | 1.847546e-04 | 1 |
| HPA | HPA:0401303 | Rectum; enterocytes[High] | Rectum; enterocytes[High] | 11 | 1.875368e-04 | 1 |
| HPA | HPA:0290000 | Liver | Liver | 67 | 2.053064e-04 | 1 |
| HPA | HPA:0380202 | Placenta; endothelial cells[≥Medium] | Placenta; endothelial cells[≥Medium] | 13 | 2.090856e-04 | 1 |
| HPA | HPA:0030443 | Appendix; non-germinal center cells[High] | Appendix; non-germinal center cells[High] | 8 | 2.144492e-04 | 1 |
| HPA | HPA:0130892 | Colon; goblet cells[≥Medium] | Colon; goblet cells[≥Medium] | 13 | 2.236445e-04 | 1 |
| HPA | HPA:0130201 | Colon; endothelial cells[≥Low] | Colon; endothelial cells[≥Low] | 63 | 2.284253e-04 | 1 |
| HPA | HPA:0300000 | Lung | Lung | 73 | 2.423040e-04 | 1 |
| HPA | HPA:0130651 | Colon; fibroblasts[≥Low] | Colon; fibroblasts[≥Low] | 8 | 2.481276e-04 | 1 |
| HPA | HPA:0480892 | Small intestine; goblet cells[≥Medium] | Small intestine; goblet cells[≥Medium] | 13 | 2.640822e-04 | 1 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 72 | 2.643514e-04 | 1 |
| HPA | HPA:0471453 | Skin 2; hair follicles[High] | Skin 2; hair follicles[High] | 6 | 2.701167e-04 | 1 |
| HPA | HPA:0400892 | Rectum; goblet cells[≥Medium] | Rectum; goblet cells[≥Medium] | 13 | 2.820047e-04 | 1 |
| HPA | HPA:0380201 | Placenta; endothelial cells[≥Low] | Placenta; endothelial cells[≥Low] | 14 | 3.131192e-04 | 1 |
| HPA | HPA:0510701 | Soft tissue 2; peripheral nerve[≥Low] | Soft tissue 2; peripheral nerve[≥Low] | 44 | 3.799191e-04 | 1 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 63 | 3.865859e-04 | 1 |
| HPA | HPA:0481303 | Small intestine; enterocytes[High] | Small intestine; enterocytes[High] | 11 | 3.975589e-04 | 1 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 62 | 4.088744e-04 | 1 |
| HPA | HPA:0031301 | Appendix; enterocytes[≥Low] | Appendix; enterocytes[≥Low] | 15 | 4.193302e-04 | 1 |
| HPA | HPA:0570000 | Testis | Testis | 80 | 4.332611e-04 | 1 |
| HPA | HPA:0320101 | Nasopharynx; respiratory epithelial cells[≥Low] | Nasopharynx; respiratory epithelial cells[≥Low] | 63 | 4.619050e-04 | 1 |
| HPA | HPA:0381212 | Placenta; syncytiotrophoblasts - cell body[≥Medium] | Placenta; syncytiotrophoblasts - cell body[≥Medium] | 15 | 4.651127e-04 | 1 |
| HPA | HPA:0131293 | Colon; endocrine cells[High] | Colon; endocrine cells[High] | 11 | 4.842665e-04 | 1 |
| HPA | HPA:0381211 | Placenta; syncytiotrophoblasts - cell body[≥Low] | Placenta; syncytiotrophoblasts - cell body[≥Low] | 16 | 4.976409e-04 | 1 |
| HPA | HPA:0381213 | Placenta; syncytiotrophoblasts - cell body[High] | Placenta; syncytiotrophoblasts - cell body[High] | 13 | 4.991264e-04 | 1 |
| HPA | HPA:0400201 | Rectum; endothelial cells[≥Low] | Rectum; endothelial cells[≥Low] | 11 | 5.651867e-04 | 1 |
| HPA | HPA:0130893 | Colon; goblet cells[High] | Colon; goblet cells[High] | 10 | 5.844474e-04 | 1 |
| HPA | HPA:0471452 | Skin 2; hair follicles[≥Medium] | Skin 2; hair follicles[≥Medium] | 9 | 6.014337e-04 | 1 |
| HPA | HPA:0031292 | Appendix; endocrine cells[≥Medium] | Appendix; endocrine cells[≥Medium] | 13 | 6.174770e-04 | 1 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 71 | 6.195668e-04 | 1 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 71 | 6.195668e-04 | 1 |
| HPA | HPA:0480893 | Small intestine; goblet cells[High] | Small intestine; goblet cells[High] | 10 | 6.378419e-04 | 1 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 62 | 6.541779e-04 | 1 |
| HPA | HPA:0130000 | Colon | Colon | 77 | 7.555178e-04 | 1 |
| HPA | HPA:0131301 | Colon; enterocytes[≥Low] | Colon; enterocytes[≥Low] | 15 | 8.270667e-04 | 1 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 14 | 8.516902e-04 | 1 |
| HPA | HPA:0130653 | Colon; fibroblasts[High] | Colon; fibroblasts[High] | 6 | 8.609643e-04 | 1 |
| HPA | HPA:0500113 | Soft tissue 1; chondrocytes[High] | Soft tissue 1; chondrocytes[High] | 12 | 8.757823e-04 | 1 |
| HPA | HPA:0241101 | Heart muscle; cardiomyocytes[≥Low] | Heart muscle; cardiomyocytes[≥Low] | 66 | 9.148069e-04 | 1 |
| HPA | HPA:0240000 | Heart muscle | Heart muscle | 66 | 9.148069e-04 | 1 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 69 | 9.177871e-04 | 1 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 69 | 9.177871e-04 | 1 |
| HPA | HPA:0401293 | Rectum; endocrine cells[High] | Rectum; endocrine cells[High] | 11 | 9.497148e-04 | 1 |
| HPA | HPA:0401301 | Rectum; enterocytes[≥Low] | Rectum; enterocytes[≥Low] | 15 | 1.002647e-03 | 1 |
| HPA | HPA:0030891 | Appendix; goblet cells[≥Low] | Appendix; goblet cells[≥Low] | 13 | 1.014812e-03 | 1 |
| HPA | HPA:0030071 | Appendix; lymphoid tissue[≥Low] | Appendix; lymphoid tissue[≥Low] | 55 | 1.199488e-03 | 1 |
| HPA | HPA:0290401 | Liver; hepatocytes[≥Low] | Liver; hepatocytes[≥Low] | 62 | 1.257973e-03 | 1 |
| HPA | HPA:0150892 | Duodenum; goblet cells[≥Medium] | Duodenum; goblet cells[≥Medium] | 12 | 1.357790e-03 | 1 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 56 | 1.422858e-03 | 1 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 13 | 1.497839e-03 | 1 |
| HPA | HPA:0130652 | Colon; fibroblasts[≥Medium] | Colon; fibroblasts[≥Medium] | 7 | 1.538507e-03 | 1 |
| HPA | HPA:0400653 | Rectum; fibroblasts[High] | Rectum; fibroblasts[High] | 6 | 1.556433e-03 | 1 |
| HPA | HPA:0131292 | Colon; endocrine cells[≥Medium] | Colon; endocrine cells[≥Medium] | 13 | 1.581322e-03 | 1 |
| HPA | HPA:0030893 | Appendix; goblet cells[High] | Appendix; goblet cells[High] | 9 | 1.582231e-03 | 1 |
| HPA | HPA:0150891 | Duodenum; goblet cells[≥Low] | Duodenum; goblet cells[≥Low] | 13 | 1.714278e-03 | 1 |
| HPA | HPA:0401292 | Rectum; endocrine cells[≥Medium] | Rectum; endocrine cells[≥Medium] | 13 | 1.714278e-03 | 1 |
| HPA | HPA:0270000 | Kidney | Kidney | 76 | 1.783635e-03 | 1 |
| HPA | HPA:0151301 | Duodenum; enterocytes[≥Low] | Duodenum; enterocytes[≥Low] | 15 | 1.827338e-03 | 1 |
| HPA | HPA:0481293 | Small intestine; endocrine cells[High] | Small intestine; endocrine cells[High] | 11 | 1.828263e-03 | 1 |
| HPA | HPA:0151303 | Duodenum; enterocytes[High] | Duodenum; enterocytes[High] | 10 | 1.900515e-03 | 1 |
| HPA | HPA:0500112 | Soft tissue 1; chondrocytes[≥Medium] | Soft tissue 1; chondrocytes[≥Medium] | 26 | 1.946657e-03 | 1 |
| HPA | HPA:0400891 | Rectum; goblet cells[≥Low] | Rectum; goblet cells[≥Low] | 13 | 2.010215e-03 | 1 |
| HPA | HPA:0480891 | Small intestine; goblet cells[≥Low] | Small intestine; goblet cells[≥Low] | 13 | 2.010215e-03 | 1 |
| HPA | HPA:0130891 | Colon; goblet cells[≥Low] | Colon; goblet cells[≥Low] | 13 | 2.118442e-03 | 1 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 68 | 2.249873e-03 | 1 |
| HPA | HPA:0031303 | Appendix; enterocytes[High] | Appendix; enterocytes[High] | 9 | 2.349912e-03 | 1 |
| HPA | HPA:0100203 | Cerebral cortex; endothelial cells[High] | Cerebral cortex; endothelial cells[High] | 13 | 2.538938e-03 | 1 |
| HPA | HPA:0031291 | Appendix; endocrine cells[≥Low] | Appendix; endocrine cells[≥Low] | 13 | 2.538938e-03 | 1 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 75 | 3.193490e-03 | 1 |
| HPA | HPA:0471451 | Skin 2; hair follicles[≥Low] | Skin 2; hair follicles[≥Low] | 9 | 3.280484e-03 | 1 |
| HPA | HPA:0131332 | Colon; mucosal lymphoid cells[≥Medium] | Colon; mucosal lymphoid cells[≥Medium] | 12 | 3.326608e-03 | 1 |
| HPA | HPA:0481353 | Small intestine; paneth cells[High] | Small intestine; paneth cells[High] | 8 | 3.332821e-03 | 1 |
| HPA | HPA:0481301 | Small intestine; enterocytes[≥Low] | Small intestine; enterocytes[≥Low] | 15 | 3.641537e-03 | 1 |
| HPA | HPA:0270361 | Kidney; cells in tubules[≥Low] | Kidney; cells in tubules[≥Low] | 69 | 3.709279e-03 | 1 |
| HPA | HPA:0440000 | Skeletal muscle | Skeletal muscle | 62 | 3.875118e-03 | 1 |
| HPA | HPA:0440341 | Skeletal muscle; myocytes[≥Low] | Skeletal muscle; myocytes[≥Low] | 62 | 3.875118e-03 | 1 |
| HPA | HPA:0400243 | Rectum; peripheral nerve/ganglion[High] | Rectum; peripheral nerve/ganglion[High] | 7 | 4.509371e-03 | 1 |
| HPA | HPA:0131291 | Colon; endocrine cells[≥Low] | Colon; endocrine cells[≥Low] | 13 | 4.818271e-03 | 1 |
| HPA | HPA:0150893 | Duodenum; goblet cells[High] | Duodenum; goblet cells[High] | 9 | 4.871355e-03 | 1 |
| HPA | HPA:0401291 | Rectum; endocrine cells[≥Low] | Rectum; endocrine cells[≥Low] | 13 | 5.420552e-03 | 1 |
| HPA | HPA:0400053 | Rectum; glandular cells[High] | Rectum; glandular cells[High] | 36 | 5.595992e-03 | 1 |
| HPA | HPA:0270362 | Kidney; cells in tubules[≥Medium] | Kidney; cells in tubules[≥Medium] | 61 | 6.305997e-03 | 1 |
| HPA | HPA:0481292 | Small intestine; endocrine cells[≥Medium] | Small intestine; endocrine cells[≥Medium] | 13 | 6.672936e-03 | 1 |
| HPA | HPA:0151353 | Duodenum; paneth cells[High] | Duodenum; paneth cells[High] | 8 | 7.254400e-03 | 1 |
| HPA | HPA:0340451 | Ovary; follicle cells[≥Low] | Ovary; follicle cells[≥Low] | 42 | 7.572979e-03 | 1 |
| HPA | HPA:0030053 | Appendix; glandular cells[High] | Appendix; glandular cells[High] | 29 | 9.302585e-03 | 1 |
| HPA | HPA:0030432 | Appendix; germinal center cells[≥Medium] | Appendix; germinal center cells[≥Medium] | 9 | 9.737450e-03 | 1 |
| HPA | HPA:0481352 | Small intestine; paneth cells[≥Medium] | Small intestine; paneth cells[≥Medium] | 9 | 9.737450e-03 | 1 |
| HPA | HPA:0031293 | Appendix; endocrine cells[High] | Appendix; endocrine cells[High] | 9 | 1.043159e-02 | 1 |
| HPA | HPA:0290402 | Liver; hepatocytes[≥Medium] | Liver; hepatocytes[≥Medium] | 45 | 1.333494e-02 | 1 |
| HPA | HPA:0151291 | Duodenum; endocrine cells[≥Low] | Duodenum; endocrine cells[≥Low] | 13 | 1.370289e-02 | 1 |
| HPA | HPA:0481291 | Small intestine; endocrine cells[≥Low] | Small intestine; endocrine cells[≥Low] | 13 | 1.399119e-02 | 1 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 12 | 1.514006e-02 | 1 |
| HPA | HPA:0151293 | Duodenum; endocrine cells[High] | Duodenum; endocrine cells[High] | 10 | 1.749069e-02 | 1 |
| HPA | HPA:0100202 | Cerebral cortex; endothelial cells[≥Medium] | Cerebral cortex; endothelial cells[≥Medium] | 34 | 1.861932e-02 | 1 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 70 | 1.928844e-02 | 1 |
| HPA | HPA:0400242 | Rectum; peripheral nerve/ganglion[≥Medium] | Rectum; peripheral nerve/ganglion[≥Medium] | 8 | 1.953125e-02 | 1 |
| HPA | HPA:0131331 | Colon; mucosal lymphoid cells[≥Low] | Colon; mucosal lymphoid cells[≥Low] | 13 | 1.976960e-02 | 1 |
| HPA | HPA:0151352 | Duodenum; paneth cells[≥Medium] | Duodenum; paneth cells[≥Medium] | 9 | 2.261351e-02 | 1 |
| HPA | HPA:0151292 | Duodenum; endocrine cells[≥Medium] | Duodenum; endocrine cells[≥Medium] | 12 | 2.396238e-02 | 1 |
| HPA | HPA:0570733 | Testis; Leydig cells[High] | Testis; Leydig cells[High] | 27 | 2.412727e-02 | 1 |
| HPA | HPA:0151343 | Duodenum; glands of Brunner[High] | Duodenum; glands of Brunner[High] | 6 | 2.735248e-02 | 1 |
| HPA | HPA:0481351 | Small intestine; paneth cells[≥Low] | Small intestine; paneth cells[≥Low] | 9 | 2.869810e-02 | 1 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 54 | 2.898151e-02 | 1 |
| HPA | HPA:0401331 | Rectum; mucosal lymphoid cells[≥Low] | Rectum; mucosal lymphoid cells[≥Low] | 13 | 3.778566e-02 | 1 |
| HPA | HPA:0151351 | Duodenum; paneth cells[≥Low] | Duodenum; paneth cells[≥Low] | 9 | 4.754144e-02 | 1 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 34 | 8.983025e-18 | 1 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 35 | 1.153875e-10 | 1 |
| MIRNA | MIRNA:hsa-let-7b-5p | hsa-let-7b-5p | hsa-let-7b-5p | 26 | 5.957471e-08 | 1 |
| MIRNA | MIRNA:hsa-mir-484 | hsa-mir-484 | hsa-mir-484 | 33 | 2.580126e-07 | 1 |
| MIRNA | MIRNA:hsa-mir-149-5p | hsa-mir-149-5p | hsa-mir-149-5p | 15 | 6.348937e-07 | 1 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 26 | 1.206021e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 19 | 1.799125e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 24 | 2.043308e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-221-3p | hsa-mir-221-3p | hsa-mir-221-3p | 13 | 3.633229e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-25-3p | hsa-mir-25-3p | hsa-mir-25-3p | 14 | 4.281850e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-1296-5p | hsa-mir-1296-5p | hsa-mir-1296-5p | 8 | 1.008711e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-877-3p | hsa-mir-877-3p | hsa-mir-877-3p | 15 | 1.806223e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-100-5p | hsa-mir-100-5p | hsa-mir-100-5p | 10 | 3.860411e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-186-5p | hsa-mir-186-5p | hsa-mir-186-5p | 16 | 5.035060e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-320c | hsa-mir-320c | hsa-mir-320c | 22 | 6.461975e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-26a-5p | hsa-mir-26a-5p | hsa-mir-26a-5p | 12 | 1.743153e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-324-3p | hsa-mir-324-3p | hsa-mir-324-3p | 23 | 2.217734e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-222-3p | hsa-mir-222-3p | hsa-mir-222-3p | 11 | 3.180975e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-15b-5p | hsa-mir-15b-5p | hsa-mir-15b-5p | 15 | 3.399927e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-3613-3p | hsa-mir-3613-3p | hsa-mir-3613-3p | 33 | 3.751972e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-320b | hsa-mir-320b | hsa-mir-320b | 21 | 3.842282e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-1229-3p | hsa-mir-1229-3p | hsa-mir-1229-3p | 8 | 4.921945e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-548ac | hsa-mir-548ac | hsa-mir-548ac | 25 | 5.367644e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-548z | hsa-mir-548z | hsa-mir-548z | 25 | 5.367644e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-548d-3p | hsa-mir-548d-3p | hsa-mir-548d-3p | 25 | 5.628077e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-18a-3p | hsa-mir-18a-3p | hsa-mir-18a-3p | 10 | 7.350845e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-320d | hsa-mir-320d | hsa-mir-320d | 20 | 7.800374e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-4429 | hsa-mir-4429 | hsa-mir-4429 | 20 | 7.889672e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-30a-5p | hsa-mir-30a-5p | hsa-mir-30a-5p | 14 | 1.012596e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-505-3p | hsa-mir-505-3p | hsa-mir-505-3p | 8 | 1.034864e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-548aa | hsa-mir-548aa | hsa-mir-548aa | 23 | 1.078416e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-10a-5p | hsa-mir-10a-5p | hsa-mir-10a-5p | 11 | 1.088398e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-331-3p | hsa-mir-331-3p | hsa-mir-331-3p | 19 | 1.181234e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3163 | hsa-mir-3163 | hsa-mir-3163 | 29 | 1.879072e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 10 | 2.749746e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-548o | hsa-mir-548o | hsa-mir-548o | 20 | 2.932652e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-15a-5p | hsa-mir-15a-5p | hsa-mir-15a-5p | 13 | 3.456019e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-93-3p | hsa-mir-93-3p | hsa-mir-93-3p | 8 | 3.779118e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-206 | hsa-mir-206 | hsa-mir-206 | 17 | 4.108613e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-125b-5p | hsa-mir-125b-5p | hsa-mir-125b-5p | 10 | 4.753514e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-6778-5p | hsa-mir-6778-5p | hsa-mir-6778-5p | 6 | 4.787122e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3617 | hsa-mir-3617 | hsa-mir-3617 | 18 | 4.812372e-02 | 1 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-72163 | mRNA Splicing - Major Pathway | mRNA Splicing - Major Pathway | 20 | 9.229108e-15 | 1 |
| REAC | REAC:R-HSA-72172 | mRNA Splicing | mRNA Splicing | 20 | 1.814637e-14 | 1 |
| REAC | REAC:R-HSA-3371511 | HSF1 activation | HSF1 activation | 8 | 1.518177e-12 | 1 |
| REAC | REAC:R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | Processing of Capped Intron-Containing Pre-mRNA | 20 | 4.106208e-12 | 1 |
| REAC | REAC:R-HSA-3371556 | Cellular response to heat stress | Cellular response to heat stress | 13 | 2.671153e-11 | 1 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 32 | 6.610564e-10 | 1 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 28 | 6.327134e-09 | 1 |
| REAC | REAC:R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins | SUMO E3 ligases SUMOylate target proteins | 14 | 1.341547e-08 | 1 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 25 | 1.488110e-08 | 1 |
| REAC | REAC:R-HSA-2990846 | SUMOylation | SUMOylation | 14 | 2.132060e-08 | 1 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 39 | 5.498485e-08 | 1 |
| REAC | REAC:R-HSA-73894 | DNA Repair | DNA Repair | 17 | 1.163786e-07 | 1 |
| REAC | REAC:R-HSA-5696398 | Nucleotide Excision Repair | Nucleotide Excision Repair | 10 | 2.814957e-06 | 1 |
| REAC | REAC:R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | Global Genome Nucleotide Excision Repair (GG-NER) | 9 | 5.001228e-06 | 1 |
| REAC | REAC:R-HSA-69473 | G2/M DNA damage checkpoint | G2/M DNA damage checkpoint | 9 | 1.359729e-05 | 1 |
| REAC | REAC:R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | Regulation of HSF1-mediated heat shock response | 8 | 1.431684e-05 | 1 |
| REAC | REAC:R-HSA-3371568 | Attenuation phase | Attenuation phase | 5 | 1.738318e-05 | 1 |
| REAC | REAC:R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 5 | 2.592081e-05 | 1 |
| REAC | REAC:R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translation | Respiratory syncytial virus (RSV) genome replication, transcription and translation | 5 | 3.748040e-05 | 1 |
| REAC | REAC:R-HSA-9679506 | SARS-CoV Infections | SARS-CoV Infections | 16 | 1.075399e-04 | 1 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 29 | 1.449500e-04 | 1 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 14 | 1.745713e-04 | 1 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 10 | 1.965355e-04 | 1 |
| REAC | REAC:R-HSA-5693532 | DNA Double-Strand Break Repair | DNA Double-Strand Break Repair | 10 | 2.317330e-04 | 1 |
| REAC | REAC:R-HSA-3899300 | SUMOylation of transcription cofactors | SUMOylation of transcription cofactors | 6 | 2.365981e-04 | 1 |
| REAC | REAC:R-HSA-5696395 | Formation of Incision Complex in GG-NER | Formation of Incision Complex in GG-NER | 6 | 3.169609e-04 | 1 |
| REAC | REAC:R-HSA-3371571 | HSF1-dependent transactivation | HSF1-dependent transactivation | 5 | 3.478455e-04 | 1 |
| REAC | REAC:R-HSA-9678108 | SARS-CoV-1 Infection | SARS-CoV-1 Infection | 9 | 4.230813e-04 | 1 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 20 | 5.376414e-04 | 1 |
| REAC | REAC:R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 4 | 6.028191e-04 | 1 |
| REAC | REAC:R-HSA-73893 | DNA Damage Bypass | DNA Damage Bypass | 6 | 6.191295e-04 | 1 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 20 | 7.055073e-04 | 1 |
| REAC | REAC:R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 4 | 8.657425e-04 | 1 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 34 | 9.070362e-04 | 1 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 18 | 9.606559e-04 | 1 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 5 | 1.125580e-03 | 1 |
| REAC | REAC:R-HSA-5633007 | Regulation of TP53 Activity | Regulation of TP53 Activity | 9 | 1.288171e-03 | 1 |
| REAC | REAC:R-HSA-111447 | Activation of BAD and translocation to mitochondria | Activation of BAD and translocation to mitochondria | 4 | 1.633874e-03 | 1 |
| REAC | REAC:R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Regulation of TP53 Activity through Phosphorylation | 7 | 2.379859e-03 | 1 |
| REAC | REAC:R-HSA-8876725 | Protein methylation | Protein methylation | 4 | 2.816227e-03 | 1 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 7 | 2.947795e-03 | 1 |
| REAC | REAC:R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | Cytosolic sensors of pathogen-associated DNA | 6 | 3.436183e-03 | 1 |
| REAC | REAC:R-HSA-5336415 | Uptake and function of diphtheria toxin | Uptake and function of diphtheria toxin | 3 | 3.450152e-03 | 1 |
| REAC | REAC:R-HSA-5696394 | DNA Damage Recognition in GG-NER | DNA Damage Recognition in GG-NER | 5 | 3.781465e-03 | 1 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 27 | 4.171164e-03 | 1 |
| REAC | REAC:R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | 5 | 4.312011e-03 | 1 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 11 | 4.320241e-03 | 1 |
| REAC | REAC:R-HSA-110320 | Translesion Synthesis by POLH | Translesion Synthesis by POLH | 4 | 4.533994e-03 | 1 |
| REAC | REAC:R-HSA-5696400 | Dual Incision in GG-NER | Dual Incision in GG-NER | 5 | 5.546539e-03 | 1 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 11 | 5.764950e-03 | 1 |
| REAC | REAC:R-HSA-9612973 | Autophagy | Autophagy | 8 | 6.634695e-03 | 1 |
| REAC | REAC:R-HSA-9613829 | Chaperone Mediated Autophagy | Chaperone Mediated Autophagy | 4 | 8.410552e-03 | 1 |
| REAC | REAC:R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6 | 8.639237e-03 | 1 |
| REAC | REAC:R-HSA-9833482 | PKR-mediated signaling | PKR-mediated signaling | 6 | 8.639237e-03 | 1 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 9 | 1.075902e-02 | 1 |
| REAC | REAC:R-HSA-9663891 | Selective autophagy | Selective autophagy | 6 | 1.251200e-02 | 1 |
| REAC | REAC:R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4 | 1.429610e-02 | 1 |
| REAC | REAC:R-HSA-180786 | Extension of Telomeres | Extension of Telomeres | 5 | 1.638944e-02 | 1 |
| REAC | REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | Intrinsic Pathway for Apoptosis | 5 | 2.167780e-02 | 1 |
| REAC | REAC:R-HSA-6798695 | Neutrophil degranulation | Neutrophil degranulation | 13 | 2.207622e-02 | 1 |
| REAC | REAC:R-HSA-9834752 | Respiratory syncytial virus genome replication | Respiratory syncytial virus genome replication | 2 | 2.381871e-02 | 1 |
| REAC | REAC:R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | Assembly and release of respiratory syncytial virus (RSV) virions | 2 | 2.381871e-02 | 1 |
| REAC | REAC:R-HSA-9694516 | SARS-CoV-2 Infection | SARS-CoV-2 Infection | 10 | 2.761698e-02 | 1 |
| REAC | REAC:R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | 5 | 2.819765e-02 | 1 |
| REAC | REAC:R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | Recognition of DNA damage by PCNA-containing replication complex | 4 | 3.009495e-02 | 1 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 22 | 3.557538e-02 | 1 |
| REAC | REAC:R-HSA-9614399 | Regulation of localization of FOXO transcription factors | Regulation of localization of FOXO transcription factors | 3 | 3.672850e-02 | 1 |
| REAC | REAC:R-HSA-69190 | DNA strand elongation | DNA strand elongation | 4 | 3.903924e-02 | 1 |
| REAC | REAC:R-HSA-5656169 | Termination of translesion DNA synthesis | Termination of translesion DNA synthesis | 4 | 3.903924e-02 | 1 |
| REAC | REAC:R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | Gap-filling DNA repair synthesis and ligation in TC-NER | 5 | 3.913018e-02 | 1 |
| REAC | REAC:R-HSA-6782135 | Dual incision in TC-NER | Dual incision in TC-NER | 5 | 4.231252e-02 | 1 |
| REAC | REAC:R-HSA-68962 | Activation of the pre-replicative complex | Activation of the pre-replicative complex | 4 | 4.416994e-02 | 1 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 8 | 4.682502e-02 | 1 |
| REAC | REAC:R-HSA-3270619 | IRF3-mediated induction of type I IFN | IRF3-mediated induction of type I IFN | 3 | 4.748733e-02 | 1 |
| REAC | REAC:R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | Antiviral mechanism by IFN-stimulated genes | 7 | 4.958344e-02 | 1 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 23 | 4.985281e-02 | 1 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP411 | mRNA processing | mRNA processing | 17 | 8.517978e-14 | 1 |
| WP | WP:WP4016 | DNA IR damage and cellular response via ATR | DNA IR damage and cellular response via ATR | 10 | 3.438991e-07 | 1 |
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 10 | 8.308558e-06 | 1 |
| WP | WP:WP3594 | Circadian rhythm genes | Circadian rhythm genes | 12 | 2.942087e-05 | 1 |
| WP | WP:WP5376 | 17p13 3 YWHAE copy number variation | 17p13 3 YWHAE copy number variation | 5 | 1.566121e-04 | 1 |
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 9 | 1.694704e-04 | 1 |
| WP | WP:WP5114 | Nucleotide excision repair in xeroderma pigmentosum | Nucleotide excision repair in xeroderma pigmentosum | 7 | 6.600214e-04 | 1 |
| WP | WP:WP3959 | DNA IR double strand breaks and cellular response via ATM | DNA IR double strand breaks and cellular response via ATM | 6 | 1.472120e-03 | 1 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 8 | 1.811821e-03 | 1 |
| WP | WP:WP2359 | Parkin ubiquitin proteasomal system pathway | Parkin ubiquitin proteasomal system pathway | 6 | 6.496047e-03 | 1 |
| WP | WP:WP438 | Non homologous end joining | Non homologous end joining | 3 | 1.361153e-02 | 1 |
| WP | WP:WP706 | Sudden infant death syndrome SIDS susceptibility pathways | Sudden infant death syndrome SIDS susceptibility pathways | 8 | 1.382376e-02 | 1 |
| WP | WP:WP3875 | ATR signaling | ATR signaling | 3 | 1.859581e-02 | 1 |
| WP | WP:WP2272 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 5 | 2.113581e-02 | 1 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 5 | 4.352047e-02 | 1 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 17 | 1.017408e-12 | 1 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 9 | 2.054279e-03 | 1 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 8 | 2.386039e-03 | 1 |
| KEGG | KEGG:05134 | Legionellosis | Legionellosis | 5 | 5.928928e-03 | 1 |
| KEGG | KEGG:03420 | Nucleotide excision repair | Nucleotide excision repair | 5 | 8.957233e-03 | 1 |
| KEGG | KEGG:03450 | Non-homologous end-joining | Non-homologous end-joining | 3 | 1.021207e-02 | 1 |
| KEGG | KEGG:03030 | DNA replication | DNA replication | 4 | 1.388693e-02 | 1 |
| KEGG | KEGG:04612 | Antigen processing and presentation | Antigen processing and presentation | 5 | 1.611749e-02 | 1 |
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 7 | 1.788228e-02 | 1 |
| KEGG | KEGG:03440 | Homologous recombination | Homologous recombination | 4 | 2.317717e-02 | 1 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 7 | 2.707369e-02 | 1 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | Thyroid hormone signaling pathway | 6 | 2.927045e-02 | 1 |
| KEGG | KEGG:03083 | Polycomb repressive complex | Polycomb repressive complex | 5 | 4.041816e-02 | 1 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1332 | Large Drosha complex | Large Drosha complex | 10 | 1.219311e-10 | 1 |
| CORUM | CORUM:1181 | C complex spliceosome | C complex spliceosome | 13 | 2.660742e-07 | 1 |
| CORUM | CORUM:1183 | CDC5L complex | CDC5L complex | 8 | 2.813160e-06 | 1 |
| CORUM | CORUM:5199 | Kinase maturation complex 1 | Kinase maturation complex 1 | 6 | 4.795748e-05 | 1 |
| CORUM | CORUM:3082 | DGCR8 multiprotein complex | DGCR8 multiprotein complex | 5 | 8.642710e-05 | 1 |
| CORUM | CORUM:351 | Spliceosome | Spliceosome | 13 | 3.253464e-04 | 1 |
| CORUM | CORUM:5615 | Emerin complex 52 | Emerin complex 52 | 5 | 3.456777e-03 | 1 |
| CORUM | CORUM:5183 | DNA-PK-Ku-eIF2-NF90-NF45 complex | DNA-PK-Ku-eIF2-NF90-NF45 complex | 3 | 9.599101e-03 | 1 |
| CORUM | CORUM:1166 | p400-associated complex | p400-associated complex | 3 | 1.891747e-02 | 1 |
| CORUM | CORUM:1335 | SNW1 complex | SNW1 complex | 4 | 2.222621e-02 | 1 |
| CORUM | CORUM:2820 | BRCA1-VCP complex | BRCA1-VCP complex | 2 | 4.988966e-02 | 1 |
| CORUM | CORUM:5229 | RPA complex | RPA complex | 2 | 4.988966e-02 | 1 |
| CORUM | CORUM:7312 | CTNNB1-ESR1 complex | CTNNB1-ESR1 complex | 2 | 4.988966e-02 | 1 |
| CORUM | CORUM:5261 | TCF4-CTNNB1-EP300 complex | TCF4-CTNNB1-EP300 complex | 2 | 4.988966e-02 | 1 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00737_1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | 41 | 3.448865e-09 | 1 |
| TF | TF:M00050_1 | Factor: E2F; motif: TTTSGCGC; match class: 1 | Factor: E2F; motif: TTTSGCGC; match class: 1 | 31 | 1.053805e-07 | 1 |
| TF | TF:M00738 | Factor: E2F-4:DP-1; motif: TTTSGCGC | Factor: E2F-4:DP-1; motif: TTTSGCGC | 73 | 1.540133e-07 | 1 |
| TF | TF:M00050 | Factor: E2F; motif: TTTSGCGC | Factor: E2F; motif: TTTSGCGC | 61 | 2.869609e-07 | 1 |
| TF | TF:M12597_1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | 72 | 1.186273e-06 | 1 |
| TF | TF:M10119 | Factor: REX-1; motif: GGCMGCCATTTT | Factor: REX-1; motif: GGCMGCCATTTT | 29 | 2.647108e-06 | 1 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 47 | 3.194598e-06 | 1 |
| TF | TF:M00516_1 | Factor: E2F-1; motif: TTTSGCGCGMNR; match class: 1 | Factor: E2F-1; motif: TTTSGCGCGMNR; match class: 1 | 30 | 5.278067e-06 | 1 |
| TF | TF:M00940_1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | 34 | 6.378474e-06 | 1 |
| TF | TF:M08982_1 | Factor: YY1; motif: NAANATGGCGNNN; match class: 1 | Factor: YY1; motif: NAANATGGCGNNN; match class: 1 | 26 | 1.502608e-05 | 1 |
| TF | TF:M00738_1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | 42 | 1.679102e-05 | 1 |
| TF | TF:M00740 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | 72 | 2.309809e-05 | 1 |
| TF | TF:M07370 | Factor: YY1; motif: NNNNAARATGGNNNN | Factor: YY1; motif: NNNNAARATGGNNNN | 51 | 2.906914e-05 | 1 |
| TF | TF:M00940 | Factor: E2F-1; motif: NTTTCGCGCS | Factor: E2F-1; motif: NTTTCGCGCS | 61 | 3.246042e-05 | 1 |
| TF | TF:M01035 | Factor: YY1; motif: NYNKCCATNTT | Factor: YY1; motif: NYNKCCATNTT | 51 | 5.265275e-05 | 1 |
| TF | TF:M11005_1 | Factor: LHX4; motif: NNCRTTAN; match class: 1 | Factor: LHX4; motif: NNCRTTAN; match class: 1 | 42 | 6.162581e-05 | 1 |
| TF | TF:M09641 | Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN | Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN | 36 | 9.019145e-05 | 1 |
| TF | TF:M02044 | Factor: YY1; motif: GCCGCCATTTTG | Factor: YY1; motif: GCCGCCATTTTG | 52 | 1.168585e-04 | 1 |
| TF | TF:M00426 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 76 | 1.323533e-04 | 1 |
| TF | TF:M00425 | Factor: E2F; motif: TTTCGCGC | Factor: E2F; motif: TTTCGCGC | 73 | 1.617355e-04 | 1 |
| TF | TF:M08982 | Factor: YY1; motif: NAANATGGCGNNN | Factor: YY1; motif: NAANATGGCGNNN | 56 | 1.807851e-04 | 1 |
| TF | TF:M00426_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 50 | 2.034712e-04 | 1 |
| TF | TF:M04696 | Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN | Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN | 59 | 2.059388e-04 | 1 |
| TF | TF:M00427_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 39 | 2.107737e-04 | 1 |
| TF | TF:M03924_1 | Factor: YY1; motif: NNCGCCATTNN; match class: 1 | Factor: YY1; motif: NNCGCCATTNN; match class: 1 | 38 | 2.369908e-04 | 1 |
| TF | TF:M12275 | Factor: YY1; motif: NGCCGCCATYTTGN | Factor: YY1; motif: NGCCGCCATYTTGN | 55 | 2.815720e-04 | 1 |
| TF | TF:M02102 | Factor: NRF-1; motif: YGCGCMTGCGC | Factor: NRF-1; motif: YGCGCMTGCGC | 27 | 2.911496e-04 | 1 |
| TF | TF:M12597 | Factor: E2F1; motif: GSGCGGGAAN | Factor: E2F1; motif: GSGCGGGAAN | 82 | 3.215808e-04 | 1 |
| TF | TF:M07380 | Factor: E2F-4; motif: NTTTCSCGCC | Factor: E2F-4; motif: NTTTCSCGCC | 79 | 3.241608e-04 | 1 |
| TF | TF:M07380_1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | 60 | 3.302378e-04 | 1 |
| TF | TF:M00740_1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | 43 | 3.364586e-04 | 1 |
| TF | TF:M07234 | Factor: YY1; motif: CAARATGGCNGC | Factor: YY1; motif: CAARATGGCNGC | 50 | 3.681799e-04 | 1 |
| TF | TF:M10104 | Factor: YY1; motif: CAARATGGCGGC | Factor: YY1; motif: CAARATGGCGGC | 50 | 4.338151e-04 | 1 |
| TF | TF:M07039 | Factor: ETF; motif: CCCCGCCCCYN | Factor: ETF; motif: CCCCGCCCCYN | 87 | 4.397570e-04 | 1 |
| TF | TF:M08020 | Factor: YY2; motif: NNCCGCCATTW | Factor: YY2; motif: NNCCGCCATTW | 23 | 5.512561e-04 | 1 |
| TF | TF:M02052 | Factor: EHF; motif: CSCGGAARTN | Factor: EHF; motif: CSCGGAARTN | 68 | 5.817317e-04 | 1 |
| TF | TF:M00427 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 66 | 5.925665e-04 | 1 |
| TF | TF:M10436 | Factor: YY1; motif: CAANATGGCGGC | Factor: YY1; motif: CAANATGGCGGC | 60 | 6.451000e-04 | 1 |
| TF | TF:M10956_1 | Factor: isx; motif: NTCRTTAA; match class: 1 | Factor: isx; motif: NTCRTTAA; match class: 1 | 35 | 6.455062e-04 | 1 |
| TF | TF:M08875 | Factor: E2F; motif: NNTTTCGCGCN | Factor: E2F; motif: NNTTTCGCGCN | 51 | 6.460540e-04 | 1 |
| TF | TF:M02090 | Factor: E2F-4; motif: GCGGGAAANA | Factor: E2F-4; motif: GCGGGAAANA | 75 | 7.546430e-04 | 1 |
| TF | TF:M07084 | Factor: E2F-4; motif: NGGCGGGAARN | Factor: E2F-4; motif: NGGCGGGAARN | 71 | 7.997522e-04 | 1 |
| TF | TF:M02044_1 | Factor: YY1; motif: GCCGCCATTTTG; match class: 1 | Factor: YY1; motif: GCCGCCATTTTG; match class: 1 | 20 | 8.176696e-04 | 1 |
| TF | TF:M10436_1 | Factor: YY1; motif: CAANATGGCGGC; match class: 1 | Factor: YY1; motif: CAANATGGCGGC; match class: 1 | 28 | 8.575746e-04 | 1 |
| TF | TF:M09892 | Factor: E2F-1; motif: NNNNGGCGGGAARN | Factor: E2F-1; motif: NNNNGGCGGGAARN | 80 | 9.236786e-04 | 1 |
| TF | TF:M12273 | Factor: YY1; motif: GGCSGCCATTTTGN | Factor: YY1; motif: GGCSGCCATTTTGN | 50 | 1.009659e-03 | 1 |
| TF | TF:M00425_1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | 46 | 1.184038e-03 | 1 |
| TF | TF:M00737 | Factor: E2F-1:DP-2; motif: TTTSSCGC | Factor: E2F-1:DP-2; motif: TTTSSCGC | 62 | 1.191204e-03 | 1 |
| TF | TF:M09892_1 | Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 | Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 | 64 | 1.262512e-03 | 1 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 81 | 1.341945e-03 | 1 |
| TF | TF:M04823_1 | Factor: E2F-4; motif: NNTTCCCGCCNN; match class: 1 | Factor: E2F-4; motif: NNTTCCCGCCNN; match class: 1 | 58 | 1.571496e-03 | 1 |
| TF | TF:M09896 | Factor: E2F-7; motif: GRGGCGGGAANNN | Factor: E2F-7; motif: GRGGCGGGAANNN | 67 | 1.594884e-03 | 1 |
| TF | TF:M04823 | Factor: E2F-4; motif: NNTTCCCGCCNN | Factor: E2F-4; motif: NNTTCCCGCCNN | 77 | 2.009618e-03 | 1 |
| TF | TF:M09893 | Factor: E2F-3; motif: NNGGCGGGAAA | Factor: E2F-3; motif: NNGGCGGGAAA | 49 | 2.238395e-03 | 1 |
| TF | TF:M12600 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | 61 | 2.337165e-03 | 1 |
| TF | TF:M07052 | Factor: NRF-1; motif: GCGCMTGCGCN | Factor: NRF-1; motif: GCGCMTGCGCN | 26 | 2.464189e-03 | 1 |
| TF | TF:M00739_1 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 | 19 | 2.679747e-03 | 1 |
| TF | TF:M00736 | Factor: E2F-1:DP-1; motif: TTTCSCGC | Factor: E2F-1:DP-1; motif: TTTCSCGC | 68 | 2.856575e-03 | 1 |
| TF | TF:M07206_1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | 70 | 2.949376e-03 | 1 |
| TF | TF:M04953_1 | Factor: Sp1; motif: GGNDGGRGGCGGGG; match class: 1 | Factor: Sp1; motif: GGNDGGRGGCGGGG; match class: 1 | 38 | 4.228293e-03 | 1 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 83 | 5.630167e-03 | 1 |
| TF | TF:M12277 | Factor: YY2; motif: NKCSGCCATTTTGN | Factor: YY2; motif: NKCSGCCATTTTGN | 7 | 6.021654e-03 | 1 |
| TF | TF:M07039_1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | 79 | 6.125057e-03 | 1 |
| TF | TF:M00939 | Factor: E2F; motif: TTTSGCGSG | Factor: E2F; motif: TTTSGCGSG | 50 | 6.183607e-03 | 1 |
| TF | TF:M07397_1 | Factor: ZBP89; motif: CCCCKCCCCCNN; match class: 1 | Factor: ZBP89; motif: CCCCKCCCCCNN; match class: 1 | 31 | 6.386424e-03 | 1 |
| TF | TF:M08910_1 | Factor: C/EBPBETA; motif: KRTTGCGYAAY; match class: 1 | Factor: C/EBPBETA; motif: KRTTGCGYAAY; match class: 1 | 32 | 7.553254e-03 | 1 |
| TF | TF:M10018 | Factor: NRF-1; motif: CNSTGCGCATGCGCNNS | Factor: NRF-1; motif: CNSTGCGCATGCGCNNS | 23 | 7.869339e-03 | 1 |
| TF | TF:M11435_1 | Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 | Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 | 46 | 8.974517e-03 | 1 |
| TF | TF:M12310 | Factor: ZNF597; motif: NGCCGCCATTTTGN | Factor: ZNF597; motif: NGCCGCCATTTTGN | 11 | 9.024664e-03 | 1 |
| TF | TF:M07370_1 | Factor: YY1; motif: NNNNAARATGGNNNN; match class: 1 | Factor: YY1; motif: NNNNAARATGGNNNN; match class: 1 | 17 | 1.005211e-02 | 1 |
| TF | TF:M04950 | Factor: Egr-1; motif: NGCGTGCGY | Factor: Egr-1; motif: NGCGTGCGY | 69 | 1.011975e-02 | 1 |
| TF | TF:M02281_1 | Factor: SP1; motif: CCCCKCCCCC; match class: 1 | Factor: SP1; motif: CCCCKCCCCC; match class: 1 | 28 | 1.032402e-02 | 1 |
| TF | TF:M10948_1 | Factor: rax; motif: NNCRTTAN; match class: 1 | Factor: rax; motif: NNCRTTAN; match class: 1 | 43 | 1.092884e-02 | 1 |
| TF | TF:M07395 | Factor: Sp1; motif: NGGGGCGGGGN | Factor: Sp1; motif: NGGGGCGGGGN | 68 | 1.172929e-02 | 1 |
| TF | TF:M00918 | Factor: E2F; motif: TTTSGCGSG | Factor: E2F; motif: TTTSGCGSG | 45 | 1.304099e-02 | 1 |
| TF | TF:M08875_1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | 22 | 1.362946e-02 | 1 |
| TF | TF:M02090_1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | 49 | 1.379549e-02 | 1 |
| TF | TF:M08874_1 | Factor: E2F1; motif: NNNNNGCGSSAAAN; match class: 1 | Factor: E2F1; motif: NNNNNGCGSSAAAN; match class: 1 | 25 | 1.394459e-02 | 1 |
| TF | TF:M00431 | Factor: E2F-1; motif: TTTSGCGS | Factor: E2F-1; motif: TTTSGCGS | 53 | 1.674055e-02 | 1 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 82 | 1.767649e-02 | 1 |
| TF | TF:M01104 | Factor: MOVO-B; motif: GNGGGGG | Factor: MOVO-B; motif: GNGGGGG | 66 | 1.811814e-02 | 1 |
| TF | TF:M00938 | Factor: E2F-1; motif: TTGGCGCGRAANNGNM | Factor: E2F-1; motif: TTGGCGCGRAANNGNM | 53 | 1.873401e-02 | 1 |
| TF | TF:M03925_1 | Factor: YY2; motif: NCCGCCATNTY; match class: 1 | Factor: YY2; motif: NCCGCCATNTY; match class: 1 | 14 | 1.974826e-02 | 1 |
| TF | TF:M10072 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | 67 | 1.976556e-02 | 1 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 84 | 2.091440e-02 | 1 |
| TF | TF:M00516 | Factor: E2F-1; motif: TTTSGCGCGMNR | Factor: E2F-1; motif: TTTSGCGCGMNR | 51 | 2.219186e-02 | 1 |
| TF | TF:M12160 | Factor: KLF15; motif: RCCMCRCCCMCN | Factor: KLF15; motif: RCCMCRCCCMCN | 75 | 2.296704e-02 | 1 |
| TF | TF:M02036_1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | Factor: WT1; motif: CGCCCCCNCN; match class: 1 | 43 | 2.538805e-02 | 1 |
| TF | TF:M07234_1 | Factor: YY1; motif: CAARATGGCNGC; match class: 1 | Factor: YY1; motif: CAARATGGCNGC; match class: 1 | 17 | 2.734314e-02 | 1 |
| TF | TF:M11435 | Factor: Elk-1; motif: NNCCGGAAGTN | Factor: Elk-1; motif: NNCCGGAAGTN | 71 | 2.768479e-02 | 1 |
| TF | TF:M00939_1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | 21 | 2.906192e-02 | 1 |
| TF | TF:M04694 | Factor: NRF-1; motif: CNCTGCGCATGCGC | Factor: NRF-1; motif: CNCTGCGCATGCGC | 20 | 2.908702e-02 | 1 |
| TF | TF:M00976 | Factor: AhR,; motif: NRCGTGNGN | Factor: AhR,; motif: NRCGTGNGN | 35 | 2.933127e-02 | 1 |
| TF | TF:M00428 | Factor: E2F-1; motif: NKTSSCGC | Factor: E2F-1; motif: NKTSSCGC | 60 | 3.033025e-02 | 1 |
| TF | TF:M03925 | Factor: YY2; motif: NCCGCCATNTY | Factor: YY2; motif: NCCGCCATNTY | 39 | 3.068054e-02 | 1 |
| TF | TF:M12596 | Factor: DP2; motif: NNGGCGGGARN | Factor: DP2; motif: NNGGCGGGARN | 26 | 3.447276e-02 | 1 |
| TF | TF:M09894 | Factor: E2F-4; motif: SNGGGCGGGAANN | Factor: E2F-4; motif: SNGGGCGGGAANN | 85 | 3.549408e-02 | 1 |
| TF | TF:M00793 | Factor: YY1; motif: GCCATNTTN | Factor: YY1; motif: GCCATNTTN | 38 | 3.571749e-02 | 1 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 66 | 3.638284e-02 | 1 |
| TF | TF:M04691_1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | 66 | 3.941442e-02 | 1 |
| TF | TF:M12271 | Factor: ZNF339; motif: NNACCGTTANNNN | Factor: ZNF339; motif: NNACCGTTANNNN | 14 | 3.981517e-02 | 1 |
| TF | TF:M11396 | Factor: Erg; motif: NACCGGAARTN | Factor: Erg; motif: NACCGGAARTN | 67 | 4.079778e-02 | 1 |
| TF | TF:M04691 | Factor: Kaiso; motif: TCTCGCGAG | Factor: Kaiso; motif: TCTCGCGAG | 82 | 4.169128e-02 | 1 |
| TF | TF:M10098 | Factor: DP-1; motif: NRNNGGCGGGAANN | Factor: DP-1; motif: NRNNGGCGGGAANN | 51 | 4.513851e-02 | 1 |
| TF | TF:M04517 | Factor: E2F2; motif: AAAATGGCGCCATTTT | Factor: E2F2; motif: AAAATGGCGCCATTTT | 60 | 4.533166e-02 | 1 |
| TF | TF:M07084_1 | Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 | Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 | 43 | 4.537188e-02 | 1 |
| TF | TF:M03958 | Factor: E2F2; motif: AAAAATGGCGCCAAAAWG | Factor: E2F2; motif: AAAAATGGCGCCAAAAWG | 67 | 4.705858e-02 | 1 |
| TF | TF:M01597_1 | Factor: Zfp281; motif: TGGGGGAGGGG; match class: 1 | Factor: Zfp281; motif: TGGGGGAGGGG; match class: 1 | 5 | 4.850030e-02 | 1 |
| TF | TF:M11529 | Factor: E2F-2; motif: GCGCGCGCNCS | Factor: E2F-2; motif: GCGCGCGCNCS | 85 | 4.951920e-02 | 1 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0000006 | Autosomal dominant inheritance | A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele. | 31 | 0.002257 | 1 |
| HP | HP:0002977 | Aplasia/Hypoplasia involving the central nervous system | Absence or underdevelopment of tissue in the central nervous system. | 30 | 0.004824 | 1 |
| HP | HP:0007364 | Aplasia/Hypoplasia of the cerebrum | Aplasia/Hypoplasia of the cerebrum | 27 | 0.007886 | 1 |
| HP | HP:0001442 | Typified by somatic mosaicism | Description of conditions in which affected individuals typically display somatic mosaicism, i.e., genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations. In many conditions typified by somatic mosaicism, constitutive mutation is lethal and cases are exclusively or predominantly mosaic. | 9 | 0.008563 | 1 |
| HP | HP:0002060 | Abnormal cerebral morphology | Any structural abnormality of the telencephalon, which is also known as the cerebrum. | 31 | 0.008822 | 1 |
| HP | HP:0100526 | Neoplasm of the lung | Tumor of the lung. | 6 | 0.012547 | 1 |
| HP | HP:0100547 | Abnormal forebrain morphology | An abnormality of the forebrain, which has as its parts the telencephalon, diencephalon, lateral ventricles and third ventricle. | 31 | 0.012675 | 1 |
| HP | HP:0010785 | Gonadal neoplasm | A tumor (abnormal growth of tissue) of a gonad. | 7 | 0.018313 | 1 |
| HP | HP:0000252 | Microcephaly | Head circumference below 2 standard deviations below the mean for age and gender. | 24 | 0.018971 | 1 |
| HP | HP:0040195 | Decreased head circumference | An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean. | 24 | 0.022624 | 1 |
| HP | HP:0002683 | Abnormal calvaria morphology | Abnormality of the morphology (structure) of the calvaria (skullcap), that is, of that part of the skull that is made up of the superior portions of the frontal bone, occipital bone, and parietal bones and covers the cranial cavity that contains the brain. | 20 | 0.026550 | 1 |
| HP | HP:0100615 | Ovarian neoplasm | A tumor (abnormal growth of tissue) of the ovary. | 6 | 0.029213 | 1 |
| HP | HP:0100606 | Neoplasm of the respiratory system | A tumor (abnormal growth of tissue) of the respiratory system. | 6 | 0.036728 | 1 |
| HP | HP:0000240 | Abnormality of skull size | Any abnormality of the size of the skull. | 26 | 0.045643 | 1 |
| HP | HP:0025134 | Increased serum estradiol | An elevation above normal limits of the concentration of estradiol in the circulation. | 3 | 0.049557 | 1 |
Community 2
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 18 | 6.943932e-24 | 2 |
| GO:CC | GO:0030863 | cortical cytoskeleton | "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] | 10 | 1.390107e-15 | 2 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 20 | 2.867525e-15 | 2 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 15 | 3.508844e-14 | 2 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 12 | 2.171498e-13 | 2 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 12 | 2.866894e-13 | 2 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 11 | 7.049686e-13 | 2 |
| GO:CC | GO:0042641 | actomyosin | "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] | 8 | 3.934167e-12 | 2 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 17 | 1.049524e-10 | 2 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 13 | 4.276513e-10 | 2 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 13 | 4.699921e-10 | 2 |
| GO:CC | GO:0032432 | actin filament bundle | "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] | 7 | 6.273524e-10 | 2 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 16 | 3.202629e-09 | 2 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 13 | 1.960849e-08 | 2 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 20 | 2.140594e-08 | 2 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 21 | 3.151757e-08 | 2 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 21 | 3.161520e-08 | 2 |
| GO:CC | GO:0030864 | cortical actin cytoskeleton | "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] | 6 | 3.447532e-08 | 2 |
| GO:CC | GO:0001725 | stress fiber | "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] | 6 | 3.703797e-08 | 2 |
| GO:CC | GO:0097517 | contractile actin filament bundle | "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194] | 6 | 3.703797e-08 | 2 |
| GO:CC | GO:0005884 | actin filament | "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] | 6 | 3.271544e-07 | 2 |
| GO:CC | GO:0030016 | myofibril | "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] | 7 | 4.338332e-07 | 2 |
| GO:CC | GO:0043292 | contractile muscle fiber | "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] | 7 | 5.759406e-07 | 2 |
| GO:CC | GO:0031252 | cell leading edge | "The area of a motile cell closest to the direction of movement." [GOC:pg] | 8 | 9.148151e-07 | 2 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 13 | 6.528546e-06 | 2 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 9 | 7.486161e-06 | 2 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 12 | 2.575383e-05 | 2 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 12 | 3.010581e-05 | 2 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 12 | 3.026164e-05 | 2 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 12 | 3.026164e-05 | 2 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 7 | 9.315003e-05 | 2 |
| GO:CC | GO:0001726 | ruffle | "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] | 5 | 1.599676e-04 | 2 |
| GO:CC | GO:0030017 | sarcomere | "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] | 5 | 3.685327e-04 | 2 |
| GO:CC | GO:0098590 | plasma membrane region | "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] | 9 | 4.432122e-04 | 2 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 17 | 5.810879e-04 | 2 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 22 | 6.471428e-04 | 2 |
| GO:CC | GO:0005903 | brush border | "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] | 4 | 7.148563e-04 | 2 |
| GO:CC | GO:0150034 | distal axon | "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] | 5 | 1.272482e-03 | 2 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 16 | 1.415397e-03 | 2 |
| GO:CC | GO:0002102 | podosome | "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] | 3 | 1.608577e-03 | 2 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 12 | 3.341386e-03 | 2 |
| GO:CC | GO:0030426 | growth cone | "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] | 4 | 3.817709e-03 | 2 |
| GO:CC | GO:0032154 | cleavage furrow | "The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409] | 3 | 3.923316e-03 | 2 |
| GO:CC | GO:0098862 | cluster of actin-based cell projections | "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos] | 4 | 4.187100e-03 | 2 |
| GO:CC | GO:0031253 | cell projection membrane | "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah] | 5 | 4.206904e-03 | 2 |
| GO:CC | GO:0030427 | site of polarized growth | "Any part of a cell where non-isotropic growth takes place." [GOC:mah] | 4 | 4.283411e-03 | 2 |
| GO:CC | GO:0016459 | myosin complex | "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin] | 3 | 4.605466e-03 | 2 |
| GO:CC | GO:0043005 | neuron projection | "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] | 8 | 5.155559e-03 | 2 |
| GO:CC | GO:0030424 | axon | "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] | 6 | 6.120862e-03 | 2 |
| GO:CC | GO:0008091 | spectrin | "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194] | 2 | 6.138505e-03 | 2 |
| GO:CC | GO:0032153 | cell division site | "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305] | 3 | 9.576331e-03 | 2 |
| GO:CC | GO:1990498 | mitotic spindle microtubule | "Any microtubule that is part of a mitotic spindle; anchored at one spindle pole." [GOC:vw] | 2 | 2.037564e-02 | 2 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 12 | 2.486630e-02 | 2 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 12 | 4.269797e-02 | 2 |
| GO:CC | GO:0005865 | striated muscle thin filament | "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] | 2 | 4.277806e-02 | 2 |
| GO:CC | GO:0032982 | myosin filament | "A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah] | 2 | 4.663891e-02 | 2 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 16 | 4.372166e-20 | 2 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 18 | 5.296849e-18 | 2 |
| GO:MF | GO:0051015 | actin filament binding | "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] | 12 | 2.043047e-16 | 2 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 9 | 1.116410e-08 | 2 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 12 | 6.070258e-07 | 2 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 9 | 1.108216e-06 | 2 |
| GO:MF | GO:0005516 | calmodulin binding | "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] | 5 | 8.089202e-04 | 2 |
| GO:MF | GO:0005200 | structural constituent of cytoskeleton | "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] | 4 | 2.093832e-03 | 2 |
| GO:MF | GO:0043531 | ADP binding | "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl] | 3 | 8.176690e-03 | 2 |
| GO:MF | GO:0005522 | profilin binding | "Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544] | 2 | 1.638167e-02 | 2 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 6 | 2.878202e-02 | 2 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 19 | 5.680812e-17 | 2 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 16 | 9.452960e-17 | 2 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 16 | 6.822729e-16 | 2 |
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 14 | 7.253673e-16 | 2 |
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 15 | 8.597413e-14 | 2 |
| GO:BP | GO:0030042 | actin filament depolymerization | "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] | 7 | 1.385916e-10 | 2 |
| GO:BP | GO:0051261 | protein depolymerization | "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] | 8 | 2.673981e-10 | 2 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 19 | 5.533701e-10 | 2 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 11 | 7.425563e-10 | 2 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] | 10 | 1.292808e-09 | 2 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 10 | 1.552891e-09 | 2 |
| GO:BP | GO:0110053 | regulation of actin filament organization | "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv] | 9 | 2.478552e-09 | 2 |
| GO:BP | GO:0030834 | regulation of actin filament depolymerization | "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] | 6 | 1.484336e-08 | 2 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 16 | 1.669456e-08 | 2 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] | 9 | 2.114342e-08 | 2 |
| GO:BP | GO:0031032 | actomyosin structure organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] | 8 | 2.502054e-08 | 2 |
| GO:BP | GO:0032984 | protein-containing complex disassembly | "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah] | 8 | 1.165479e-07 | 2 |
| GO:BP | GO:1901879 | regulation of protein depolymerization | "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] | 6 | 4.210496e-07 | 2 |
| GO:BP | GO:0008154 | actin polymerization or depolymerization | "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] | 7 | 7.020038e-07 | 2 |
| GO:BP | GO:0030835 | negative regulation of actin filament depolymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah] | 5 | 9.262334e-07 | 2 |
| GO:BP | GO:0043244 | regulation of protein-containing complex disassembly | "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] | 6 | 3.349030e-06 | 2 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 11 | 3.833882e-06 | 2 |
| GO:BP | GO:0008064 | regulation of actin polymerization or depolymerization | "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] | 6 | 7.713567e-06 | 2 |
| GO:BP | GO:0030832 | regulation of actin filament length | "Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah] | 6 | 8.709780e-06 | 2 |
| GO:BP | GO:0022411 | cellular component disassembly | "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] | 8 | 9.044431e-06 | 2 |
| GO:BP | GO:0051494 | negative regulation of cytoskeleton organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 6 | 1.060599e-05 | 2 |
| GO:BP | GO:1902904 | negative regulation of supramolecular fiber organization | "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 6 | 1.145443e-05 | 2 |
| GO:BP | GO:0032272 | negative regulation of protein polymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 5 | 1.172272e-05 | 2 |
| GO:BP | GO:1901880 | negative regulation of protein depolymerization | "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] | 5 | 1.257669e-05 | 2 |
| GO:BP | GO:0043242 | negative regulation of protein-containing complex disassembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] | 5 | 2.415681e-05 | 2 |
| GO:BP | GO:0051693 | actin filament capping | "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] | 4 | 9.652555e-05 | 2 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 8 | 1.839685e-04 | 2 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 9 | 3.395508e-04 | 2 |
| GO:BP | GO:0031333 | negative regulation of protein-containing complex assembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] | 5 | 3.590691e-04 | 2 |
| GO:BP | GO:0030837 | negative regulation of actin filament polymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] | 4 | 4.429188e-04 | 2 |
| GO:BP | GO:0051014 | actin filament severing | "The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234] | 3 | 8.509213e-04 | 2 |
| GO:BP | GO:0030239 | myofibril assembly | "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] | 4 | 1.323845e-03 | 2 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 6 | 1.361533e-03 | 2 |
| GO:BP | GO:0032535 | regulation of cellular component size | "A process that modulates the size of a cellular component." [GOC:mah] | 6 | 1.454148e-03 | 2 |
| GO:BP | GO:0000910 | cytokinesis | "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle] | 5 | 1.601507e-03 | 2 |
| GO:BP | GO:0032271 | regulation of protein polymerization | "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 5 | 1.910553e-03 | 2 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 19 | 1.987075e-03 | 2 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 19 | 3.114856e-03 | 2 |
| GO:BP | GO:0022607 | cellular component assembly | "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] | 15 | 3.538482e-03 | 2 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 6 | 4.345271e-03 | 2 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 7 | 5.051043e-03 | 2 |
| GO:BP | GO:0070925 | organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 8 | 6.117310e-03 | 2 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 15 | 7.271060e-03 | 2 |
| GO:BP | GO:0030043 | actin filament fragmentation | "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins." [GOC:mah, ISBN:0815316194] | 2 | 8.372892e-03 | 2 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb] | 6 | 1.033520e-02 | 2 |
| GO:BP | GO:0030833 | regulation of actin filament polymerization | "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] | 4 | 1.064313e-02 | 2 |
| GO:BP | GO:0051258 | protein polymerization | "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] | 5 | 1.087819e-02 | 2 |
| GO:BP | GO:0016477 | cell migration | "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] | 9 | 1.104859e-02 | 2 |
| GO:BP | GO:1902396 | protein localization to bicellular tight junction | "A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction." [GOC:TermGenie, PMID:18332111] | 2 | 1.394641e-02 | 2 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system." [GOC:dph, GOC:mah, GOC:tb] | 4 | 1.433615e-02 | 2 |
| GO:BP | GO:0010927 | cellular component assembly involved in morphogenesis | "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] | 4 | 1.433615e-02 | 2 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai] | 5 | 1.441969e-02 | 2 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] | 9 | 1.465831e-02 | 2 |
| GO:BP | GO:0034330 | cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] | 7 | 1.581542e-02 | 2 |
| GO:BP | GO:0030030 | cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917] | 9 | 1.822075e-02 | 2 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] | 11 | 2.413668e-02 | 2 |
| GO:BP | GO:0051017 | actin filament bundle assembly | "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] | 4 | 2.569449e-02 | 2 |
| GO:BP | GO:0030041 | actin filament polymerization | "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] | 4 | 2.633205e-02 | 2 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 8 | 2.703095e-02 | 2 |
| GO:BP | GO:0061572 | actin filament bundle organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] | 4 | 2.764202e-02 | 2 |
| GO:BP | GO:0055002 | striated muscle cell development | "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol] | 4 | 3.336641e-02 | 2 |
| GO:BP | GO:1902905 | positive regulation of supramolecular fiber organization | "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 4 | 3.819899e-02 | 2 |
| GO:BP | GO:0048870 | cell motility | "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] | 9 | 3.917007e-02 | 2 |
| GO:BP | GO:0051495 | positive regulation of cytoskeleton organization | "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 4 | 4.638712e-02 | 2 |
| GO:BP | GO:0051293 | establishment of spindle localization | "The directed movement of the spindle to a specific location in the cell." [GOC:ai] | 3 | 4.824595e-02 | 2 |
| GO:BP | GO:0000902 | cell morphogenesis | "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] | 7 | 4.991928e-02 | 2 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 11 | 1.870967e-07 | 2 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 11 | 2.346815e-07 | 2 |
| REAC | REAC:R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | Sensory processing of sound by outer hair cells of the cochlea | 5 | 4.190021e-06 | 2 |
| REAC | REAC:R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | Sensory processing of sound by inner hair cells of the cochlea | 5 | 1.289497e-05 | 2 |
| REAC | REAC:R-HSA-9659379 | Sensory processing of sound | Sensory processing of sound | 5 | 2.307404e-05 | 2 |
| REAC | REAC:R-HSA-195258 | RHO GTPase Effectors | RHO GTPase Effectors | 7 | 7.912213e-05 | 2 |
| REAC | REAC:R-HSA-9013424 | RHOV GTPase cycle | RHOV GTPase cycle | 4 | 8.262119e-05 | 2 |
| REAC | REAC:R-HSA-9013420 | RHOU GTPase cycle | RHOU GTPase cycle | 4 | 1.026999e-04 | 2 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 7 | 7.525565e-04 | 2 |
| REAC | REAC:R-HSA-1500931 | Cell-Cell communication | Cell-Cell communication | 5 | 7.905000e-04 | 2 |
| REAC | REAC:R-HSA-5627117 | RHO GTPases Activate ROCKs | RHO GTPases Activate ROCKs | 3 | 9.678494e-04 | 2 |
| REAC | REAC:R-HSA-5627123 | RHO GTPases activate PAKs | RHO GTPases activate PAKs | 3 | 1.325886e-03 | 2 |
| REAC | REAC:R-HSA-373753 | Nephrin family interactions | Nephrin family interactions | 3 | 1.762152e-03 | 2 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 7 | 2.863214e-03 | 2 |
| REAC | REAC:R-HSA-2682334 | EPH-Ephrin signaling | EPH-Ephrin signaling | 4 | 3.039878e-03 | 2 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 7 | 3.850043e-03 | 2 |
| REAC | REAC:R-HSA-445095 | Interaction between L1 and Ankyrins | Interaction between L1 and Ankyrins | 3 | 4.438500e-03 | 2 |
| REAC | REAC:R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | Regulation of actin dynamics for phagocytic cup formation | 4 | 8.310791e-03 | 2 |
| REAC | REAC:R-HSA-373760 | L1CAM interactions | L1CAM interactions | 4 | 9.190491e-03 | 2 |
| REAC | REAC:R-HSA-9012999 | RHO GTPase cycle | RHO GTPase cycle | 6 | 1.245953e-02 | 2 |
| REAC | REAC:R-HSA-5673001 | RAF/MAP kinase cascade | RAF/MAP kinase cascade | 5 | 1.283450e-02 | 2 |
| REAC | REAC:R-HSA-5684996 | MAPK1/MAPK3 signaling | MAPK1/MAPK3 signaling | 5 | 1.403201e-02 | 2 |
| REAC | REAC:R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | Fcgamma receptor (FCGR) dependent phagocytosis | 4 | 1.739175e-02 | 2 |
| REAC | REAC:R-HSA-5683057 | MAPK family signaling cascades | MAPK family signaling cascades | 5 | 2.663711e-02 | 2 |
| REAC | REAC:R-HSA-196025 | Formation of annular gap junctions | Formation of annular gap junctions | 2 | 4.057975e-02 | 2 |
| REAC | REAC:R-HSA-190873 | Gap junction degradation | Gap junction degradation | 2 | 4.865145e-02 | 2 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 10 | 0.000023 | 2 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 11 | 0.000047 | 2 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 10 | 0.000307 | 2 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 7 | 0.000307 | 2 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 8 | 0.001895 | 2 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 9 | 0.001935 | 2 |
| HPA | HPA:0031322 | Appendix; enterocytes - Microvilli[≥Medium] | Appendix; enterocytes - Microvilli[≥Medium] | 5 | 0.003235 | 2 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 9 | 0.004270 | 2 |
| HPA | HPA:0031323 | Appendix; enterocytes - Microvilli[High] | Appendix; enterocytes - Microvilli[High] | 4 | 0.005384 | 2 |
| HPA | HPA:0401321 | Rectum; enterocytes - Microvilli[≥Low] | Rectum; enterocytes - Microvilli[≥Low] | 5 | 0.006371 | 2 |
| HPA | HPA:0031321 | Appendix; enterocytes - Microvilli[≥Low] | Appendix; enterocytes - Microvilli[≥Low] | 5 | 0.006527 | 2 |
| HPA | HPA:0131322 | Colon; enterocytes - Microvilli[≥Medium] | Colon; enterocytes - Microvilli[≥Medium] | 5 | 0.007882 | 2 |
| HPA | HPA:0131321 | Colon; enterocytes - Microvilli[≥Low] | Colon; enterocytes - Microvilli[≥Low] | 5 | 0.010769 | 2 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 9 | 0.013822 | 2 |
| HPA | HPA:0481322 | Small intestine; enterocytes - Microvilli[≥Medium] | Small intestine; enterocytes - Microvilli[≥Medium] | 5 | 0.014708 | 2 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 20 | 0.016982 | 2 |
| HPA | HPA:0481321 | Small intestine; enterocytes - Microvilli[≥Low] | Small intestine; enterocytes - Microvilli[≥Low] | 5 | 0.026778 | 2 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 7 | 0.031629 | 2 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04814 | Motor proteins | Motor proteins | 5 | 0.000349 | 2 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 5 | 0.000771 | 2 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | Proteoglycans in cancer | 4 | 0.010851 | 2 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 7 | 0.001819 | 2 |
| WP | WP:WP383 | Striated muscle contraction pathway | Striated muscle contraction pathway | 3 | 0.008206 | 2 |
| WP | WP:WP524 | G13 signaling | G13 signaling | 3 | 0.008206 | 2 |
| WP | WP:WP314 | Fas ligand pathway and stress induction of heat shock proteins | Fas ligand pathway and stress induction of heat shock proteins | 3 | 0.011109 | 2 |
| WP | WP:WP4217 | Ebola virus infection in host | Ebola virus infection in host | 4 | 0.015871 | 2 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-34a-5p | hsa-mir-34a-5p | hsa-mir-34a-5p | 7 | 0.003011 | 2 |
| MIRNA | MIRNA:hsa-mir-877-3p | hsa-mir-877-3p | hsa-mir-877-3p | 7 | 0.003466 | 2 |
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 8 | 0.008551 | 2 |
| MIRNA | MIRNA:hsa-mir-337-3p | hsa-mir-337-3p | hsa-mir-337-3p | 7 | 0.018120 | 2 |
| MIRNA | MIRNA:hsa-mir-4311 | hsa-mir-4311 | hsa-mir-4311 | 9 | 0.035631 | 2 |
| MIRNA | MIRNA:hsa-mir-3658 | hsa-mir-3658 | hsa-mir-3658 | 9 | 0.038588 | 2 |
| MIRNA | MIRNA:hsa-mir-4436b-3p | hsa-mir-4436b-3p | hsa-mir-4436b-3p | 9 | 0.048253 | 2 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M07461_1 | Factor: KLF; motif: GGGNGGGG; match class: 1 | Factor: KLF; motif: GGGNGGGG; match class: 1 | 14 | 0.004203 | 2 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2837 | Profilin 1 complex | Profilin 1 complex | 2 | 0.007621 | 2 |
| CORUM | CORUM:5604 | Emerin complex 1 | Emerin complex 1 | 2 | 0.021262 | 2 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0000437 | Depressed nasal tip | Decreased distance from the nasal tip to the nasal base. | 3 | 0.023083 | 2 |
Community 3
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051086 | chaperone mediated protein folding independent of cofactor | "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] | 8 | 3.162859e-22 | 3 |
| GO:BP | GO:1904874 | positive regulation of telomerase RNA localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 2.845008e-21 | 3 |
| GO:BP | GO:1904869 | regulation of protein localization to Cajal body | "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.421722e-20 | 3 |
| GO:BP | GO:1904871 | positive regulation of protein localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.421722e-20 | 3 |
| GO:BP | GO:1904867 | protein localization to Cajal body | "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.562175e-19 | 3 |
| GO:BP | GO:1904872 | regulation of telomerase RNA localization to Cajal body | "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.562175e-19 | 3 |
| GO:BP | GO:1903405 | protein localization to nuclear body | "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849] | 8 | 1.562175e-19 | 3 |
| GO:BP | GO:1990173 | protein localization to nucleoplasm | "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952] | 8 | 9.466774e-19 | 3 |
| GO:BP | GO:0090685 | RNA localization to nucleus | "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] | 8 | 2.376132e-17 | 3 |
| GO:BP | GO:0090670 | RNA localization to Cajal body | "A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 8 | 2.376132e-17 | 3 |
| GO:BP | GO:0090672 | telomerase RNA localization | "Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 8 | 2.376132e-17 | 3 |
| GO:BP | GO:0090671 | telomerase RNA localization to Cajal body | "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 8 | 2.376132e-17 | 3 |
| GO:BP | GO:0032212 | positive regulation of telomere maintenance via telomerase | "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 8 | 2.305807e-16 | 3 |
| GO:BP | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 8 | 6.948772e-16 | 3 |
| GO:BP | GO:0051084 | 'de novo' post-translational protein folding | "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] | 8 | 4.498926e-14 | 3 |
| GO:BP | GO:0032210 | regulation of telomere maintenance via telomerase | "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 8 | 8.082145e-14 | 3 |
| GO:BP | GO:0006458 | 'de novo' protein folding | "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] | 8 | 1.167516e-13 | 3 |
| GO:BP | GO:2000573 | positive regulation of DNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 8 | 1.966889e-13 | 3 |
| GO:BP | GO:1904356 | regulation of telomere maintenance via telomere lengthening | "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 8 | 3.752648e-13 | 3 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 8 | 7.864204e-13 | 3 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 8 | 1.188411e-12 | 3 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 8 | 4.102092e-12 | 3 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 8 | 4.596781e-12 | 3 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 8 | 5.142815e-12 | 3 |
| GO:BP | GO:0007339 | binding of sperm to zona pellucida | "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] | 7 | 8.684268e-12 | 3 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 8 | 2.810917e-11 | 3 |
| GO:BP | GO:1900182 | positive regulation of protein localization to nucleus | "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 8 | 3.664604e-11 | 3 |
| GO:BP | GO:0035036 | sperm-egg recognition | "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf] | 7 | 7.125786e-11 | 3 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 8 | 8.359776e-11 | 3 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 8 | 1.420159e-10 | 3 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 9 | 5.821211e-10 | 3 |
| GO:BP | GO:0009988 | cell-cell recognition | "Cell recognition between cells. May involve the formation of specialized cell junctions." [ISBN:0824072820] | 7 | 9.058402e-10 | 3 |
| GO:BP | GO:0033044 | regulation of chromosome organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] | 9 | 1.170546e-09 | 3 |
| GO:BP | GO:1900180 | regulation of protein localization to nucleus | "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 8 | 1.234776e-09 | 3 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 8 | 3.166961e-09 | 3 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 8 | 4.653212e-09 | 3 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 8 | 1.082578e-08 | 3 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 9 | 1.363073e-08 | 3 |
| GO:BP | GO:0006403 | RNA localization | "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] | 8 | 1.567504e-08 | 3 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 9 | 2.171583e-08 | 3 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 8 | 3.246052e-08 | 3 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 10 | 8.419099e-08 | 3 |
| GO:BP | GO:0008037 | cell recognition | "The process in which a cell in an organism interprets its surroundings." [GOC:go_curators] | 7 | 1.937205e-07 | 3 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 8 | 3.130521e-07 | 3 |
| GO:BP | GO:0007338 | single fertilization | "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] | 7 | 3.651745e-07 | 3 |
| GO:BP | GO:0022414 | reproductive process | "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] | 13 | 4.884129e-07 | 3 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 9 | 6.585292e-07 | 3 |
| GO:BP | GO:1903829 | positive regulation of protein localization | "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 9 | 7.458527e-07 | 3 |
| GO:BP | GO:0009566 | fertilization | "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] | 7 | 1.712161e-06 | 3 |
| GO:BP | GO:0019953 | sexual reproduction | "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] | 11 | 3.012149e-06 | 3 |
| GO:BP | GO:0090666 | scaRNA localization to Cajal body | "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 3 | 1.261038e-05 | 3 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 8 | 2.204570e-05 | 3 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 8 | 3.949693e-05 | 3 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 10 | 4.707609e-05 | 3 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 10 | 6.760310e-05 | 3 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 9 | 1.345561e-04 | 3 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 9 | 3.452996e-04 | 3 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 13 | 7.782631e-04 | 3 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 11 | 1.413042e-03 | 3 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 9 | 1.536097e-03 | 3 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 13 | 2.819852e-03 | 3 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 15 | 3.558681e-03 | 3 |
| GO:BP | GO:1904851 | positive regulation of establishment of protein localization to telomere | "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 2 | 4.188970e-03 | 3 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 8 | 4.542725e-03 | 3 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 13 | 7.917210e-03 | 3 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 13 | 7.993705e-03 | 3 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 11 | 8.326041e-03 | 3 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 10 | 1.308192e-02 | 3 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 11 | 1.554510e-02 | 3 |
| GO:BP | GO:1904816 | positive regulation of protein localization to chromosome, telomeric region | "Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455] | 2 | 2.090702e-02 | 3 |
| GO:BP | GO:0070203 | regulation of establishment of protein localization to telomere | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah] | 2 | 2.090702e-02 | 3 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 11 | 2.270941e-02 | 3 |
| GO:BP | GO:0070202 | regulation of establishment of protein localization to chromosome | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] | 2 | 2.925219e-02 | 3 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005832 | chaperonin-containing T-complex | "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] | 8 | 1.122511e-21 | 3 |
| GO:CC | GO:0101031 | protein folding chaperone complex | "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] | 8 | 2.345137e-15 | 3 |
| GO:CC | GO:0002199 | zona pellucida receptor complex | "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732] | 5 | 4.510293e-12 | 3 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 11 | 2.955616e-11 | 3 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 15 | 2.544187e-09 | 3 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 15 | 3.119973e-09 | 3 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 15 | 3.141100e-09 | 3 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 15 | 3.141100e-09 | 3 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 12 | 5.140607e-09 | 3 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 12 | 5.607205e-09 | 3 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 13 | 7.444770e-09 | 3 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 11 | 7.611325e-09 | 3 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 13 | 8.263716e-09 | 3 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 11 | 3.415314e-08 | 3 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 19 | 7.572510e-08 | 3 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 17 | 1.285686e-07 | 3 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 15 | 1.598489e-06 | 3 |
| GO:CC | GO:0044297 | cell body | "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] | 8 | 4.753465e-06 | 3 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 13 | 6.149223e-06 | 3 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 15 | 5.179245e-05 | 3 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 21 | 1.108762e-03 | 3 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 6 | 8.860851e-03 | 3 |
| GO:CC | GO:0035578 | azurophil granule lumen | "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] | 3 | 1.488930e-02 | 3 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 15 | 1.983200e-02 | 3 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 15 | 1.986974e-02 | 3 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 6 | 2.295851e-02 | 3 |
| GO:CC | GO:0000242 | pericentriolar material | "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] | 2 | 3.442365e-02 | 3 |
| GO:CC | GO:0005881 | cytoplasmic microtubule | "Any microtubule in the cytoplasm of a cell." [GOC:mah] | 3 | 3.550762e-02 | 3 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 4 | 3.844744e-02 | 3 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 4 | 4.076973e-02 | 3 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 4 | 4.124607e-02 | 3 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | Formation of tubulin folding intermediates by CCT/TriC | 10 | 8.336940e-20 | 3 |
| REAC | REAC:R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | Prefoldin mediated transfer of substrate to CCT/TriC | 10 | 2.055965e-19 | 3 |
| REAC | REAC:R-HSA-390450 | Folding of actin by CCT/TriC | Folding of actin by CCT/TriC | 8 | 5.542450e-19 | 3 |
| REAC | REAC:R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 10 | 1.443537e-18 | 3 |
| REAC | REAC:R-HSA-390466 | Chaperonin-mediated protein folding | Chaperonin-mediated protein folding | 11 | 7.052687e-16 | 3 |
| REAC | REAC:R-HSA-391251 | Protein folding | Protein folding | 11 | 1.474886e-15 | 3 |
| REAC | REAC:R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 9 | 2.311745e-15 | 3 |
| REAC | REAC:R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | Association of TriC/CCT with target proteins during biosynthesis | 8 | 5.848301e-13 | 3 |
| REAC | REAC:R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | BBSome-mediated cargo-targeting to cilium | 6 | 7.034362e-10 | 3 |
| REAC | REAC:R-HSA-5617833 | Cilium Assembly | Cilium Assembly | 9 | 1.419799e-08 | 3 |
| REAC | REAC:R-HSA-5620920 | Cargo trafficking to the periciliary membrane | Cargo trafficking to the periciliary membrane | 6 | 1.214462e-07 | 3 |
| REAC | REAC:R-HSA-1852241 | Organelle biogenesis and maintenance | Organelle biogenesis and maintenance | 9 | 4.013523e-07 | 3 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 14 | 6.353221e-04 | 3 |
| REAC | REAC:R-HSA-9013418 | RHOBTB2 GTPase cycle | RHOBTB2 GTPase cycle | 3 | 3.339349e-03 | 3 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 8 | 9.480961e-03 | 3 |
| REAC | REAC:R-HSA-68877 | Mitotic Prometaphase | Mitotic Prometaphase | 5 | 9.771168e-03 | 3 |
| REAC | REAC:R-HSA-9706574 | RHOBTB GTPase Cycle | RHOBTB GTPase Cycle | 3 | 1.216061e-02 | 3 |
| REAC | REAC:R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | EML4 and NUDC in mitotic spindle formation | 4 | 1.905117e-02 | 3 |
| REAC | REAC:R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | Resolution of Sister Chromatid Cohesion | 4 | 2.556503e-02 | 3 |
| REAC | REAC:R-HSA-5663220 | RHO GTPases Activate Formins | RHO GTPases Activate Formins | 4 | 3.660476e-02 | 3 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:126 | CCT complex (chaperonin containing TCP1 complex) | CCT complex (chaperonin containing TCP1 complex) | 8 | 6.931506e-18 | 3 |
| CORUM | CORUM:6247 | BBS-chaperonin complex | BBS-chaperonin complex | 6 | 2.283882e-10 | 3 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 8 | 7.262652e-16 | 3 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 9 | 3.383685e-13 | 3 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 8 | 6.662838e-13 | 3 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 8 | 1.394840e-06 | 3 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 14 | 3.988925e-06 | 3 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 13 | 2.361055e-05 | 3 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 13 | 2.582751e-05 | 3 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 10 | 3.219961e-05 | 3 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 8 | 3.650004e-05 | 3 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 10 | 5.090899e-05 | 3 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 10 | 5.128889e-05 | 3 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 10 | 5.128889e-05 | 3 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 12 | 5.397799e-05 | 3 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 12 | 7.388371e-05 | 3 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 12 | 8.061505e-05 | 3 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 13 | 8.789025e-05 | 3 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 12 | 1.185562e-04 | 3 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 12 | 4.584562e-04 | 3 |
| GO:MF | GO:0016787 | hydrolase activity | "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] | 13 | 8.483659e-04 | 3 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 9 | 2.976390e-03 | 3 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 9 | 3.719050e-03 | 3 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 17 | 3.790413e-03 | 3 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 9 | 5.951590e-03 | 3 |
| GO:MF | GO:1990756 | ubiquitin-like ligase-substrate adaptor activity | "The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274] | 3 | 1.352481e-02 | 3 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 16 | 1.614969e-02 | 3 |
| GO:MF | GO:0140767 | enzyme-substrate adaptor activity | "An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity." [PMID:16250895, PMID:34358446] | 3 | 2.317081e-02 | 3 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4949 | 16p11 2 proximal deletion syndrome | 16p11 2 proximal deletion syndrome | 9 | 3.604644e-12 | 3 |
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 5 | 5.609959e-04 | 3 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 18 | 0.000100 | 3 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 19 | 0.001487 | 3 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 16 | 0.005788 | 3 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 19 | 0.013341 | 3 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 19 | 0.017046 | 3 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 19 | 0.017383 | 3 |
| HPA | HPA:0530000 | Spleen | Spleen | 18 | 0.019516 | 3 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 19 | 0.022879 | 3 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 18 | 0.027021 | 3 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 17 | 0.032440 | 3 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 19 | 0.033337 | 3 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 18 | 0.040688 | 3 |
| HPA | HPA:0050000 | Breast | Breast | 19 | 0.046837 | 3 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 19 | 0.048995 | 3 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M07114 | Factor: c-MAF:NF-E2p45; motif: ATGACTCAGCANWTN | Factor: c-MAF:NF-E2p45; motif: ATGACTCAGCANWTN | 7 | 0.015017 | 3 |
| TF | TF:M09593 | Factor: Bach1; motif: TGCTGAGTCANNS | Factor: Bach1; motif: TGCTGAGTCANNS | 6 | 0.028278 | 3 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-151a-5p | hsa-mir-151a-5p | hsa-mir-151a-5p | 3 | 0.028403 | 3 |
| MIRNA | MIRNA:hsa-mir-301a-3p | hsa-mir-301a-3p | hsa-mir-301a-3p | 5 | 0.043544 | 3 |
Community 4
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 14 | 3.674970e-10 | 4 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 14 | 4.461776e-10 | 4 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 14 | 4.490506e-10 | 4 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 14 | 4.490506e-10 | 4 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 15 | 6.031736e-09 | 4 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 15 | 1.068639e-07 | 4 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 15 | 2.360850e-07 | 4 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 7 | 2.218868e-06 | 4 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 7 | 2.602701e-06 | 4 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 4 | 2.186509e-04 | 4 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 4 | 2.186509e-04 | 4 |
| GO:CC | GO:0140534 | endoplasmic reticulum protein-containing complex | "A protein complex that is part of an endoplasmic reticulum." [GOC:pg] | 4 | 2.343998e-04 | 4 |
| GO:CC | GO:0005790 | smooth endoplasmic reticulum | "The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732] | 3 | 3.218656e-04 | 4 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 7 | 3.858338e-04 | 4 |
| GO:CC | GO:0005788 | endoplasmic reticulum lumen | "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] | 5 | 4.270796e-04 | 4 |
| GO:CC | GO:0042824 | MHC class I peptide loading complex | "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934] | 2 | 2.892154e-03 | 4 |
| GO:CC | GO:0033018 | sarcoplasmic reticulum lumen | "The volume enclosed by the membranes of the sarcoplasmic reticulum." [GOC:rph] | 2 | 3.613561e-03 | 4 |
| GO:CC | GO:0034663 | endoplasmic reticulum chaperone complex | "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] | 2 | 4.414580e-03 | 4 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 17 | 8.968960e-03 | 4 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 12 | 1.433378e-02 | 4 |
| GO:CC | GO:0071682 | endocytic vesicle lumen | "The volume enclosed by the membrane of an endocytic vesicle." [GOC:pde] | 2 | 2.019735e-02 | 4 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 6 | 0.000020 | 4 |
| GO:BP | GO:0034975 | protein folding in endoplasmic reticulum | "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw] | 3 | 0.000141 | 4 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 7 | 0.000160 | 4 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 5 | 0.002699 | 4 |
| GO:BP | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai] | 2 | 0.005424 | 4 |
| GO:BP | GO:0051017 | actin filament bundle assembly | "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] | 4 | 0.010463 | 4 |
| GO:BP | GO:0061572 | actin filament bundle organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] | 4 | 0.011261 | 4 |
| GO:BP | GO:0002502 | peptide antigen assembly with MHC class I protein complex | "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] | 2 | 0.013547 | 4 |
| GO:BP | GO:0002397 | MHC class I protein complex assembly | "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] | 2 | 0.013547 | 4 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 3 | 0.040390 | 4 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016860 | intramolecular oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators] | 4 | 0.000033 | 4 |
| GO:MF | GO:0016853 | isomerase activity | "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] | 6 | 0.000325 | 4 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 4 | 0.000560 | 4 |
| GO:MF | GO:0015035 | protein-disulfide reductase activity | "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385] | 3 | 0.000783 | 4 |
| GO:MF | GO:0015036 | disulfide oxidoreductase activity | "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [GOC:curators] | 3 | 0.001288 | 4 |
| GO:MF | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors | "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.8.-.-, GOC:ai] | 3 | 0.003394 | 4 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 3 | 0.006439 | 4 |
| GO:MF | GO:0003756 | protein disulfide isomerase activity | "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function] | 2 | 0.030413 | 4 |
| GO:MF | GO:0016864 | intramolecular oxidoreductase activity, transposing S-S bonds | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4.-, GOC:mah] | 2 | 0.030413 | 4 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 8 | 0.037582 | 4 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 9 | 0.000082 | 4 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 9 | 0.000460 | 4 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 8 | 0.000869 | 4 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 8 | 0.001610 | 4 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 8 | 0.001753 | 4 |
| HPA | HPA:0471482 | Skin 2; sebaceous glands[≥Medium] | Skin 2; sebaceous glands[≥Medium] | 4 | 0.002348 | 4 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 11 | 0.002563 | 4 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 8 | 0.003360 | 4 |
| HPA | HPA:0271122 | Kidney; collecting ducts[≥Medium] | Kidney; collecting ducts[≥Medium] | 6 | 0.004444 | 4 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 6 | 0.004666 | 4 |
| HPA | HPA:0471481 | Skin 2; sebaceous glands[≥Low] | Skin 2; sebaceous glands[≥Low] | 4 | 0.004821 | 4 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 14 | 0.005200 | 4 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 15 | 0.005579 | 4 |
| HPA | HPA:0530000 | Spleen | Spleen | 16 | 0.006819 | 4 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 15 | 0.007898 | 4 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 14 | 0.008116 | 4 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 14 | 0.008614 | 4 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 10 | 0.009165 | 4 |
| HPA | HPA:0150892 | Duodenum; goblet cells[≥Medium] | Duodenum; goblet cells[≥Medium] | 5 | 0.012594 | 4 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 9 | 0.013155 | 4 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 15 | 0.013156 | 4 |
| HPA | HPA:0271121 | Kidney; collecting ducts[≥Low] | Kidney; collecting ducts[≥Low] | 6 | 0.018694 | 4 |
| HPA | HPA:0131332 | Colon; mucosal lymphoid cells[≥Medium] | Colon; mucosal lymphoid cells[≥Medium] | 5 | 0.019144 | 4 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 7 | 0.019380 | 4 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 8 | 0.020514 | 4 |
| HPA | HPA:0030891 | Appendix; goblet cells[≥Low] | Appendix; goblet cells[≥Low] | 5 | 0.024293 | 4 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 15 | 0.024904 | 4 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 6 | 0.026518 | 4 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 5 | 0.028726 | 4 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 6 | 0.028895 | 4 |
| HPA | HPA:0150891 | Duodenum; goblet cells[≥Low] | Duodenum; goblet cells[≥Low] | 5 | 0.030451 | 4 |
| HPA | HPA:0340000 | Ovary | Ovary | 15 | 0.031986 | 4 |
| HPA | HPA:0480891 | Small intestine; goblet cells[≥Low] | Small intestine; goblet cells[≥Low] | 5 | 0.032625 | 4 |
| HPA | HPA:0130891 | Colon; goblet cells[≥Low] | Colon; goblet cells[≥Low] | 5 | 0.033375 | 4 |
| HPA | HPA:0031291 | Appendix; endocrine cells[≥Low] | Appendix; endocrine cells[≥Low] | 5 | 0.036107 | 4 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 5 | 0.039436 | 4 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 10 | 0.041724 | 4 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 5 | 0.045823 | 4 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 9 | 0.047412 | 4 |
| HPA | HPA:0131291 | Colon; endocrine cells[≥Low] | Colon; endocrine cells[≥Low] | 5 | 0.047785 | 4 |
| HPA | HPA:0151292 | Duodenum; endocrine cells[≥Medium] | Duodenum; endocrine cells[≥Medium] | 5 | 0.049299 | 4 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 4 | 0.003816 | 4 |
| KEGG | KEGG:01230 | Biosynthesis of amino acids | Biosynthesis of amino acids | 3 | 0.007792 | 4 |
| KEGG | KEGG:01200 | Carbon metabolism | Carbon metabolism | 3 | 0.028720 | 4 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-1-3p | hsa-mir-1-3p | hsa-mir-1-3p | 7 | 0.007238 | 4 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | ATF6 (ATF6-alpha) activates chaperone genes | 2 | 0.019776 | 4 |
| REAC | REAC:R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | ATF6 (ATF6-alpha) activates chaperones | 2 | 0.030166 | 4 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4628 | Aerobic glycolysis augmented | Aerobic glycolysis augmented | 2 | 0.028743 | 4 |
| WP | WP:WP1946 | Cori cycle | Cori cycle | 2 | 0.049919 | 4 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5217 | Calreticulin homo-oligomer complex | Calreticulin homo-oligomer complex | 1 | 0.04968 | 4 |
Community 5
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005783 | endoplasmic reticulum | "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] | 13 | 2.820067e-09 | 5 |
| GO:CC | GO:0031090 | organelle membrane | "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] | 15 | 7.169771e-09 | 5 |
| GO:CC | GO:0005789 | endoplasmic reticulum membrane | "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] | 11 | 7.259787e-09 | 5 |
| GO:CC | GO:0098827 | endoplasmic reticulum subcompartment | "A distinct region of the endoplasmic reticulum." [GOC:dos] | 11 | 7.649646e-09 | 5 |
| GO:CC | GO:0042175 | nuclear outer membrane-endoplasmic reticulum membrane network | "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] | 11 | 9.012368e-09 | 5 |
| GO:CC | GO:0031984 | organelle subcompartment | "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] | 11 | 9.195880e-08 | 5 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 15 | 2.410167e-07 | 5 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 5 | 1.949680e-06 | 5 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 5 | 1.949680e-06 | 5 |
| GO:CC | GO:0098588 | bounding membrane of organelle | "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] | 10 | 7.326323e-05 | 5 |
| GO:CC | GO:0030659 | cytoplasmic vesicle membrane | "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] | 8 | 1.232436e-04 | 5 |
| GO:CC | GO:0012506 | vesicle membrane | "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] | 8 | 1.381856e-04 | 5 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 12 | 1.619234e-04 | 5 |
| GO:CC | GO:0098553 | lumenal side of endoplasmic reticulum membrane | "The side (leaflet) of the plasma membrane that faces the lumen." [GOC:ab, GOC:dos] | 3 | 1.939442e-04 | 5 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 10 | 2.408626e-04 | 5 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 10 | 2.461824e-04 | 5 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 16 | 3.878640e-04 | 5 |
| GO:CC | GO:0098576 | lumenal side of membrane | "Any side (leaflet) of a membrane that faces the lumen of an organelle." [GOC:dos] | 3 | 4.579220e-04 | 5 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 9 | 5.535278e-04 | 5 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 9 | 6.228287e-04 | 5 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 9 | 6.252631e-04 | 5 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 9 | 6.252631e-04 | 5 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 12 | 9.948880e-03 | 5 |
| GO:CC | GO:0005768 | endosome | "A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] | 6 | 9.982049e-03 | 5 |
| GO:CC | GO:0005794 | Golgi apparatus | "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732] | 7 | 1.153634e-02 | 5 |
| GO:CC | GO:0000139 | Golgi membrane | "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] | 5 | 1.322374e-02 | 5 |
| GO:CC | GO:0044233 | mitochondria-associated endoplasmic reticulum membrane contact site | "A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461, PMID:22078959, PMID:29626751, PMID:29684109] | 2 | 1.582854e-02 | 5 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 9 | 2.208242e-02 | 5 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 12 | 2.304295e-02 | 5 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 10 | 2.461865e-02 | 5 |
| GO:CC | GO:0005769 | early endosome | "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] | 4 | 3.210730e-02 | 5 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003925 | G protein activity | "A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015] | 4 | 0.000018 | 5 |
| GO:MF | GO:0005525 | GTP binding | "Binding to GTP, guanosine triphosphate." [GOC:ai] | 5 | 0.022090 | 5 |
| GO:MF | GO:0019001 | guanyl nucleotide binding | "Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732] | 5 | 0.029123 | 5 |
| GO:MF | GO:0032561 | guanyl ribonucleotide binding | "Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 5 | 0.029123 | 5 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045184 | establishment of protein localization | "The directed movement of a protein to a specific location." [GOC:bf] | 10 | 0.000285 | 5 |
| GO:BP | GO:0006897 | endocytosis | "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis] | 7 | 0.000586 | 5 |
| GO:BP | GO:0070201 | regulation of establishment of protein localization | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] | 6 | 0.002414 | 5 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 11 | 0.003141 | 5 |
| GO:BP | GO:0098657 | import into cell | "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos] | 7 | 0.003420 | 5 |
| GO:BP | GO:1904951 | positive regulation of establishment of protein localization | "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] | 5 | 0.004791 | 5 |
| GO:BP | GO:0015031 | protein transport | "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 8 | 0.005270 | 5 |
| GO:BP | GO:0006810 | transport | "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] | 12 | 0.007629 | 5 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 10 | 0.008072 | 5 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 10 | 0.008400 | 5 |
| GO:BP | GO:0016192 | vesicle-mediated transport | "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] | 8 | 0.010927 | 5 |
| GO:BP | GO:0051223 | regulation of protein transport | "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 5 | 0.020107 | 5 |
| GO:BP | GO:0051234 | establishment of localization | "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] | 12 | 0.026050 | 5 |
| GO:BP | GO:1903829 | positive regulation of protein localization | "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 5 | 0.036051 | 5 |
| GO:BP | GO:0071705 | nitrogen compound transport | "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] | 8 | 0.044056 | 5 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 6 | 0.048575 | 5 |
| GO:BP | GO:0051222 | positive regulation of protein transport | "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 4 | 0.049849 | 5 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 2 | 0.000552 | 5 |
| REAC | REAC:R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3 | 0.002335 | 5 |
| REAC | REAC:R-HSA-433692 | Proton-coupled monocarboxylate transport | Proton-coupled monocarboxylate transport | 2 | 0.008259 | 5 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6131 | SELK multiprotein complex | SELK multiprotein complex | 2 | 0.003294 | 5 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04144 | Endocytosis | Endocytosis | 4 | 0.017245 | 5 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-8060 | hsa-mir-8060 | hsa-mir-8060 | 3 | 0.025778 | 5 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4301 | Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells | Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells | 2 | 0.035108 | 5 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 12 | 0.048811 | 5 |
Community 6
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0045259 | proton-transporting ATP synthase complex | "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [ISBN:0198547684, ISBN:0716743663] | 6 | 2.943042e-14 | 6 |
| GO:CC | GO:0016469 | proton-transporting two-sector ATPase complex | "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483] | 7 | 7.319738e-14 | 6 |
| GO:CC | GO:0031966 | mitochondrial membrane | "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] | 11 | 4.772442e-12 | 6 |
| GO:CC | GO:0005759 | mitochondrial matrix | "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] | 10 | 4.982704e-12 | 6 |
| GO:CC | GO:0005740 | mitochondrial envelope | "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] | 11 | 9.352789e-12 | 6 |
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 13 | 1.494394e-11 | 6 |
| GO:CC | GO:0031967 | organelle envelope | "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] | 11 | 1.398257e-09 | 6 |
| GO:CC | GO:0098803 | respiratory chain complex | "Any protein complex that is part of a respiratory chain." [GOC:dos] | 6 | 3.118780e-09 | 6 |
| GO:CC | GO:0009295 | nucleoid | "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689] | 5 | 8.878407e-09 | 6 |
| GO:CC | GO:0042645 | mitochondrial nucleoid | "The region of a mitochondrion to which the DNA is confined." [GOC:jl] | 5 | 8.878407e-09 | 6 |
| GO:CC | GO:0005743 | mitochondrial inner membrane | "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] | 8 | 2.756714e-08 | 6 |
| GO:CC | GO:0019866 | organelle inner membrane | "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] | 8 | 6.339770e-08 | 6 |
| GO:CC | GO:0034703 | cation channel complex | "An ion channel complex through which cations pass." [GOC:mah] | 6 | 3.755799e-07 | 6 |
| GO:CC | GO:1902495 | transmembrane transporter complex | "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586] | 7 | 9.710855e-07 | 6 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 10 | 1.052658e-06 | 6 |
| GO:CC | GO:1990351 | transporter complex | "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578] | 7 | 1.424896e-06 | 6 |
| GO:CC | GO:0098796 | membrane protein complex | "Any protein complex that is part of a membrane." [GOC:dos] | 9 | 2.933211e-06 | 6 |
| GO:CC | GO:0031090 | organelle membrane | "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] | 12 | 6.122082e-06 | 6 |
| GO:CC | GO:0034702 | monoatomic ion channel complex | "A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective monoatomic ion transport down its electrochemical gradient." [GOC:mah, ISBN:071673706X] | 6 | 6.402639e-06 | 6 |
| GO:CC | GO:0016507 | mitochondrial fatty acid beta-oxidation multienzyme complex | "A multienzyme complex possessing three activities in two subunits (alpha and beta) that catalyzes three steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. The alpha subunit comprises the enoyl-CoA hydratase (ECH) and 3-hydroxyacyl-CoA dehydrogenase (HACD) activities, and the beta subunit contains the acetyl-CoA C-acyltransferase (KACT)/thiolase activity." [GOC:sjm, PMID:29915090] | 2 | 1.448725e-04 | 6 |
| GO:CC | GO:0036125 | fatty acid beta-oxidation multienzyme complex | "A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT)." [GOC:imk, PMID:12115060, PMID:16472743] | 2 | 1.448725e-04 | 6 |
| GO:CC | GO:0005741 | mitochondrial outer membrane | "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] | 4 | 1.291988e-03 | 6 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 14 | 1.773574e-03 | 6 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 13 | 2.001994e-03 | 6 |
| GO:CC | GO:0031968 | organelle outer membrane | "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] | 4 | 2.138632e-03 | 6 |
| GO:CC | GO:0019867 | outer membrane | "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] | 4 | 2.204517e-03 | 6 |
| GO:CC | GO:1990204 | oxidoreductase complex | "Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432] | 3 | 1.286633e-02 | 6 |
| GO:CC | GO:0046930 | pore complex | "A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732] | 2 | 1.556466e-02 | 6 |
| GO:CC | GO:0098798 | mitochondrial protein-containing complex | "A protein complex that is part of a mitochondrion." [GOC:dos] | 3 | 2.459132e-02 | 6 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 11 | 3.441793e-02 | 6 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 11 | 3.441793e-02 | 6 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 11 | 3.441793e-02 | 6 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 14 | 4.448042e-02 | 6 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism | "Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722] | 6 | 1.416758e-13 | 6 |
| GO:MF | GO:0015252 | proton channel activity | "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] | 6 | 2.865453e-12 | 6 |
| GO:MF | GO:0015078 | proton transmembrane transporter activity | "Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai] | 7 | 3.910238e-09 | 6 |
| GO:MF | GO:0005216 | monoatomic ion channel activity | "Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] | 8 | 1.713304e-07 | 6 |
| GO:MF | GO:0015075 | monoatomic ion transmembrane transporter activity | "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] | 9 | 1.890106e-07 | 6 |
| GO:MF | GO:0016874 | ligase activity | "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-] | 6 | 2.739268e-07 | 6 |
| GO:MF | GO:0022803 | passive transmembrane transporter activity | "Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] | 8 | 4.050480e-07 | 6 |
| GO:MF | GO:0015267 | channel activity | "Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729] | 8 | 4.050480e-07 | 6 |
| GO:MF | GO:0022857 | transmembrane transporter activity | "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] | 9 | 4.198577e-06 | 6 |
| GO:MF | GO:0005215 | transporter activity | "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells." [GOC:ai, GOC:dgf] | 9 | 9.188376e-06 | 6 |
| GO:MF | GO:0022890 | inorganic cation transmembrane transporter activity | "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] | 7 | 3.958669e-05 | 6 |
| GO:MF | GO:0005261 | monoatomic cation channel activity | "Enables the energy-independent facilitated diffusion of a monoatomic cation through a transmembrane aqueous pore or channel." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729] | 6 | 5.620530e-05 | 6 |
| GO:MF | GO:0008324 | monoatomic cation transmembrane transporter activity | "Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] | 7 | 5.719152e-05 | 6 |
| GO:MF | GO:0015318 | inorganic molecular entity transmembrane transporter activity | "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon." [GOC:mtg_transport, ISBN:0815340729] | 7 | 1.204406e-04 | 6 |
| GO:MF | GO:0043532 | angiostatin binding | "Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis." [PMID:16043488] | 2 | 6.492896e-04 | 6 |
| GO:MF | GO:0043531 | ADP binding | "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl] | 3 | 1.473531e-03 | 6 |
| GO:MF | GO:0015288 | porin activity | "Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-] | 2 | 1.621941e-03 | 6 |
| GO:MF | GO:0003985 | acetyl-CoA C-acetyltransferase activity | "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [RHEA:21036] | 2 | 1.621941e-03 | 6 |
| GO:MF | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity | "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+." [EC:1.1.1.35] | 2 | 1.621941e-03 | 6 |
| GO:MF | GO:0003988 | acetyl-CoA C-acyltransferase activity | "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [RHEA:21564] | 2 | 2.269821e-03 | 6 |
| GO:MF | GO:0016453 | C-acetyltransferase activity | "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule." [GOC:ai] | 2 | 2.269821e-03 | 6 |
| GO:MF | GO:0004300 | enoyl-CoA hydratase activity | "Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O." [EC:4.2.1.17] | 2 | 8.410794e-03 | 6 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 7 | 1.186413e-02 | 6 |
| GO:MF | GO:0008142 | oxysterol binding | "Binding to oxysterol, an oxidized form of cholesterol." [GOC:curators] | 2 | 1.292435e-02 | 6 |
| GO:MF | GO:0008308 | voltage-gated monoatomic anion channel activity | "Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:vw, ISBN:0815340729] | 2 | 1.464181e-02 | 6 |
| GO:MF | GO:0097001 | ceramide binding | "Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes." [GOC:sart] | 2 | 1.646553e-02 | 6 |
| GO:MF | GO:0042288 | MHC class I protein binding | "Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] | 2 | 1.646553e-02 | 6 |
| GO:MF | GO:0016408 | C-acyltransferase activity | "Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai] | 2 | 2.043123e-02 | 6 |
| GO:MF | GO:0046961 | proton-transporting ATPase activity, rotational mechanism | "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721] | 2 | 3.219617e-02 | 6 |
| GO:MF | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | "Enables the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism." [GOC:jl] | 2 | 3.219617e-02 | 6 |
| GO:MF | GO:0042625 | ATPase-coupled ion transmembrane transporter activity | "Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] | 2 | 3.219617e-02 | 6 |
| GO:MF | GO:0046625 | sphingolipid binding | "Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732] | 2 | 3.763976e-02 | 6 |
| GO:MF | GO:0031210 | phosphatidylcholine binding | "Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732] | 2 | 4.659230e-02 | 6 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-163210 | Formation of ATP by chemiosmotic coupling | Formation of ATP by chemiosmotic coupling | 6 | 4.172672e-12 | 6 |
| REAC | REAC:R-HSA-8949613 | Cristae formation | Cristae formation | 6 | 1.643242e-10 | 6 |
| REAC | REAC:R-HSA-1592230 | Mitochondrial biogenesis | Mitochondrial biogenesis | 6 | 1.439551e-07 | 6 |
| REAC | REAC:R-HSA-1428517 | Aerobic respiration and respiratory electron transport | Aerobic respiration and respiratory electron transport | 7 | 4.080057e-07 | 6 |
| REAC | REAC:R-HSA-1852241 | Organelle biogenesis and maintenance | Organelle biogenesis and maintenance | 6 | 1.548390e-04 | 6 |
| REAC | REAC:R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 2 | 1.254134e-03 | 6 |
| REAC | REAC:R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 2 | 1.254134e-03 | 6 |
| REAC | REAC:R-HSA-9837999 | Mitochondrial protein degradation | Mitochondrial protein degradation | 4 | 1.291197e-03 | 6 |
| REAC | REAC:R-HSA-1430728 | Metabolism | Metabolism | 10 | 3.312931e-03 | 6 |
| REAC | REAC:R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 2 | 4.174875e-03 | 6 |
| REAC | REAC:R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 2 | 4.174875e-03 | 6 |
| REAC | REAC:R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 2 | 4.174875e-03 | 6 |
| REAC | REAC:R-HSA-1482798 | Acyl chain remodeling of CL | Acyl chain remodeling of CL | 2 | 6.258139e-03 | 6 |
| REAC | REAC:R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 2 | 6.258139e-03 | 6 |
| REAC | REAC:R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 2 | 6.258139e-03 | 6 |
| REAC | REAC:R-HSA-1268020 | Mitochondrial protein import | Mitochondrial protein import | 3 | 1.833344e-02 | 6 |
| REAC | REAC:R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 2 | 2.287014e-02 | 6 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis | "The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force)." [GOC:vw] | 6 | 3.223319e-09 | 6 |
| GO:BP | GO:0015986 | proton motive force-driven ATP synthesis | "The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force)." [GOC:vw] | 6 | 8.266306e-09 | 6 |
| GO:BP | GO:1902600 | proton transmembrane transport | "The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] | 7 | 1.885149e-08 | 6 |
| GO:BP | GO:0006754 | ATP biosynthetic process | "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732] | 6 | 4.299724e-08 | 6 |
| GO:BP | GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 8.038670e-08 | 6 |
| GO:BP | GO:0009145 | purine nucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 8.482485e-08 | 6 |
| GO:BP | GO:0009201 | ribonucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 1.101904e-07 | 6 |
| GO:BP | GO:0009142 | nucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 1.637198e-07 | 6 |
| GO:BP | GO:0006119 | oxidative phosphorylation | "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309] | 6 | 3.815510e-07 | 6 |
| GO:BP | GO:0009152 | purine ribonucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 6.894672e-07 | 6 |
| GO:BP | GO:0009260 | ribonucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 1.180382e-06 | 6 |
| GO:BP | GO:0046390 | ribose phosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 6 | 1.493140e-06 | 6 |
| GO:BP | GO:0006164 | purine nucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 2.056805e-06 | 6 |
| GO:BP | GO:0009060 | aerobic respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] | 6 | 2.472572e-06 | 6 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah] | 9 | 3.855975e-06 | 6 |
| GO:BP | GO:0046034 | ATP metabolic process | "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] | 6 | 5.742823e-06 | 6 |
| GO:BP | GO:0009165 | nucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] | 6 | 5.742823e-06 | 6 |
| GO:BP | GO:0045333 | cellular respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732] | 6 | 7.992824e-06 | 6 |
| GO:BP | GO:0009205 | purine ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 1.042671e-05 | 6 |
| GO:BP | GO:0072522 | purine-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 6 | 1.145138e-05 | 6 |
| GO:BP | GO:0009199 | ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 1.227346e-05 | 6 |
| GO:BP | GO:0009144 | purine nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 1.227346e-05 | 6 |
| GO:BP | GO:0044281 | small molecule metabolic process | "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] | 10 | 1.731731e-05 | 6 |
| GO:BP | GO:0009141 | nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 1.752937e-05 | 6 |
| GO:BP | GO:0006811 | monoatomic ion transport | "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai] | 9 | 2.258229e-05 | 6 |
| GO:BP | GO:0098662 | inorganic cation transmembrane transport | "A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] | 8 | 2.279352e-05 | 6 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | "The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw] | 8 | 2.804768e-05 | 6 |
| GO:BP | GO:1901293 | nucleoside phosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie] | 6 | 3.778706e-05 | 6 |
| GO:BP | GO:0098660 | inorganic ion transmembrane transport | "The process in which an inorganic ion is transported across a membrane." [GOC:mah] | 8 | 4.977467e-05 | 6 |
| GO:BP | GO:0015980 | energy derivation by oxidation of organic compounds | "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] | 6 | 6.608800e-05 | 6 |
| GO:BP | GO:0009150 | purine ribonucleotide metabolic process | "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 7.320093e-05 | 6 |
| GO:BP | GO:0009259 | ribonucleotide metabolic process | "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 1.032707e-04 | 6 |
| GO:BP | GO:0019693 | ribose phosphate metabolic process | "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 6 | 1.171238e-04 | 6 |
| GO:BP | GO:0006812 | monoatomic cation transport | "The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai] | 8 | 1.306850e-04 | 6 |
| GO:BP | GO:0055085 | transmembrane transport | "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid] | 9 | 1.376600e-04 | 6 |
| GO:BP | GO:0006163 | purine nucleotide metabolic process | "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 6 | 2.429863e-04 | 6 |
| GO:BP | GO:0006091 | generation of precursor metabolites and energy | "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] | 6 | 4.528596e-04 | 6 |
| GO:BP | GO:0009117 | nucleotide metabolic process | "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] | 6 | 5.429180e-04 | 6 |
| GO:BP | GO:0072521 | purine-containing compound metabolic process | "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 6 | 1.181018e-03 | 6 |
| GO:BP | GO:1901137 | carbohydrate derivative biosynthetic process | "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie] | 6 | 1.614548e-03 | 6 |
| GO:BP | GO:0090407 | organophosphate biosynthetic process | "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg] | 6 | 2.052600e-03 | 6 |
| GO:BP | GO:0006753 | nucleoside phosphate metabolic process | "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] | 6 | 2.630798e-03 | 6 |
| GO:BP | GO:0019637 | organophosphate metabolic process | "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] | 7 | 2.983146e-03 | 6 |
| GO:BP | GO:0055086 | nucleobase-containing small molecule metabolic process | "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] | 6 | 3.336380e-03 | 6 |
| GO:BP | GO:1901135 | carbohydrate derivative metabolic process | "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] | 6 | 2.940125e-02 | 6 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00190 | Oxidative phosphorylation | Oxidative phosphorylation | 7 | 9.142052e-09 | 6 |
| KEGG | KEGG:05415 | Diabetic cardiomyopathy | Diabetic cardiomyopathy | 7 | 1.647523e-07 | 6 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | Chemical carcinogenesis - reactive oxygen species | 7 | 3.088416e-07 | 6 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 7 | 1.092936e-06 | 6 |
| KEGG | KEGG:05020 | Prion disease | Prion disease | 7 | 1.276595e-06 | 6 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 7 | 2.892954e-06 | 6 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 7 | 1.361290e-05 | 6 |
| KEGG | KEGG:04714 | Thermogenesis | Thermogenesis | 6 | 1.857120e-05 | 6 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 7 | 5.931176e-05 | 6 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis | 6 | 2.571380e-04 | 6 |
| KEGG | KEGG:01100 | Metabolic pathways | Metabolic pathways | 9 | 1.570638e-03 | 6 |
| KEGG | KEGG:00062 | Fatty acid elongation | Fatty acid elongation | 2 | 3.713180e-02 | 6 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP623 | Oxidative phosphorylation | Oxidative phosphorylation | 6 | 1.738804e-08 | 6 |
| WP | WP:WP111 | Electron transport chain OXPHOS system in mitochondria | Electron transport chain OXPHOS system in mitochondria | 6 | 5.112366e-07 | 6 |
| WP | WP:WP4932 | 7q11 23 copy number variation syndrome | 7q11 23 copy number variation syndrome | 5 | 3.875153e-05 | 6 |
| WP | WP:WP3871 | Valproic acid pathway | Valproic acid pathway | 2 | 1.744894e-02 | 6 |
| WP | WP:WP5123 | Mitochondrial fatty acid oxidation disorders | Mitochondrial fatty acid oxidation disorders | 2 | 4.494414e-02 | 6 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0001987 | Hyperammonemia | An increased concentration of ammonia in the blood. | 5 | 0.000057 | 6 |
| HP | HP:0025145 | Rigors | Severe chills with violent shivering. A rigor is an episode of shaking or exaggerated shivering which can occur with a high fever. | 2 | 0.002359 | 6 |
| HP | HP:0002157 | Azotemia | An increased concentration of nitrogen compounds in the blood. | 5 | 0.002423 | 6 |
| HP | HP:0004364 | Abnormal circulating nitrogen compound concentration | Any deviation from the normal concentration of a nitrogen compound in the blood circulation. | 5 | 0.003381 | 6 |
| HP | HP:0006555 | Diffuse hepatic steatosis | A diffuse form of hepatic steatosis. | 2 | 0.014133 | 6 |
| HP | HP:0025144 | Shivering | Involuntary contraction or twitching of the muscles. | 2 | 0.035276 | 6 |
| HP | HP:0003201 | Rhabdomyolysis | Breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream. | 3 | 0.038343 | 6 |
| HP | HP:0003546 | Exercise intolerance | A functional motor deficit where individuals whose responses to the challenges of exercise fail to achieve levels considered normal for their age and gender. | 4 | 0.046797 | 6 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:563 | F1F0-ATP synthase, mitochondrial | F1F0-ATP synthase, mitochondrial | 3 | 0.000136 | 6 |
| CORUM | CORUM:7262 | 3-Hydroxyacyl CoA dehydrogenase | 3-Hydroxyacyl CoA dehydrogenase | 2 | 0.000422 | 6 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11772_1 | Factor: NURR1; motif: NAAAGGTCAN; match class: 1 | Factor: NURR1; motif: NAAAGGTCAN; match class: 1 | 5 | 0.001300 | 6 |
| TF | TF:M06646 | Factor: znf607; motif: NGGATCAAGAAA | Factor: znf607; motif: NGGATCAAGAAA | 2 | 0.002253 | 6 |
| TF | TF:M10119 | Factor: REX-1; motif: GGCMGCCATTTT | Factor: REX-1; motif: GGCMGCCATTTT | 8 | 0.021038 | 6 |
| TF | TF:M03542_1 | Factor: COUP-TF1; motif: TGACCTY; match class: 1 | Factor: COUP-TF1; motif: TGACCTY; match class: 1 | 6 | 0.024845 | 6 |
| TF | TF:M08968_1 | Factor: RXR-ALPHA; motif: RAGGTCA; match class: 1 | Factor: RXR-ALPHA; motif: RAGGTCA; match class: 1 | 6 | 0.024845 | 6 |
| TF | TF:M08963_1 | Factor: NR1B1; motif: RAGGTCA; match class: 1 | Factor: NR1B1; motif: RAGGTCA; match class: 1 | 6 | 0.024845 | 6 |
| TF | TF:M06438 | Factor: ZNF227; motif: NACKGGAAAACM | Factor: ZNF227; motif: NACKGGAAAACM | 2 | 0.033707 | 6 |
| TF | TF:M11427_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 11 | 0.034512 | 6 |
| TF | TF:M07234 | Factor: YY1; motif: CAARATGGCNGC | Factor: YY1; motif: CAARATGGCNGC | 12 | 0.048273 | 6 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0241102 | Heart muscle; cardiomyocytes[≥Medium] | Heart muscle; cardiomyocytes[≥Medium] | 12 | 0.002086 | 6 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 12 | 0.007613 | 6 |
| HPA | HPA:0290402 | Liver; hepatocytes[≥Medium] | Liver; hepatocytes[≥Medium] | 11 | 0.007934 | 6 |
| HPA | HPA:0570733 | Testis; Leydig cells[High] | Testis; Leydig cells[High] | 8 | 0.016281 | 6 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 9 | 0.020671 | 6 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 12 | 0.021055 | 6 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 11 | 0.021289 | 6 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 12 | 0.024432 | 6 |
| HPA | HPA:0300413 | Lung; macrophages[High] | Lung; macrophages[High] | 7 | 0.028069 | 6 |
| HPA | HPA:0150053 | Duodenum; glandular cells[High] | Duodenum; glandular cells[High] | 9 | 0.033818 | 6 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 12 | 0.042418 | 6 |
Community 7
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5399 | NPHP1 deletion syndrome | NPHP1 deletion syndrome | 2 | 0.003561 | 7 |
| WP | WP:WP3965 | Lipid metabolism pathway | Lipid metabolism pathway | 2 | 0.026109 | 7 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-552-5p | hsa-mir-552-5p | hsa-mir-552-5p | 3 | 0.007905 | 7 |
| MIRNA | MIRNA:hsa-mir-93-5p | hsa-mir-93-5p | hsa-mir-93-5p | 5 | 0.031906 | 7 |
| MIRNA | MIRNA:hsa-mir-3657 | hsa-mir-3657 | hsa-mir-3657 | 4 | 0.043466 | 7 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 3 | 0.031604 | 7 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471381 | Skin 2; arrector pili muscle cells[≥Low] | Skin 2; arrector pili muscle cells[≥Low] | 2 | 0.03879 | 7 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 8 | 0.045467 | 7 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 5 | 0.04731 | 7 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6143 | KPNB1-RAN complex | KPNB1-RAN complex | 1 | 0.049932 | 7 |
Community 8
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 12 | 1.194876e-11 | 8 |
| GO:CC | GO:0005759 | mitochondrial matrix | "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] | 9 | 4.194950e-11 | 8 |
| GO:CC | GO:0009295 | nucleoid | "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689] | 5 | 3.013387e-09 | 8 |
| GO:CC | GO:0042645 | mitochondrial nucleoid | "The region of a mitochondrion to which the DNA is confined." [GOC:jl] | 5 | 3.013387e-09 | 8 |
| GO:CC | GO:0019866 | organelle inner membrane | "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] | 6 | 2.578552e-05 | 8 |
| GO:CC | GO:0031966 | mitochondrial membrane | "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] | 6 | 1.729351e-04 | 8 |
| GO:CC | GO:0031967 | organelle envelope | "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] | 7 | 1.861536e-04 | 8 |
| GO:CC | GO:0005740 | mitochondrial envelope | "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] | 6 | 2.472298e-04 | 8 |
| GO:CC | GO:0005743 | mitochondrial inner membrane | "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] | 5 | 5.087588e-04 | 8 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 11 | 1.849503e-03 | 8 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 11 | 1.849503e-03 | 8 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 11 | 1.849503e-03 | 8 |
| GO:CC | GO:0031968 | organelle outer membrane | "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] | 3 | 3.540862e-02 | 8 |
| GO:CC | GO:0019867 | outer membrane | "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] | 3 | 3.621956e-02 | 8 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0530723 | Spleen; cells in white pulp[High] | Spleen; cells in white pulp[High] | 8 | 0.000021 | 8 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 8 | 0.000378 | 8 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 10 | 0.000468 | 8 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 8 | 0.001468 | 8 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 8 | 0.002000 | 8 |
| HPA | HPA:0271112 | Kidney; bowman's capsule[≥Medium] | Kidney; bowman's capsule[≥Medium] | 4 | 0.004301 | 8 |
| HPA | HPA:0241102 | Heart muscle; cardiomyocytes[≥Medium] | Heart muscle; cardiomyocytes[≥Medium] | 11 | 0.004949 | 8 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 7 | 0.006023 | 8 |
| HPA | HPA:0570802 | Testis; sertoli cells[≥Medium] | Testis; sertoli cells[≥Medium] | 8 | 0.008772 | 8 |
| HPA | HPA:0030433 | Appendix; germinal center cells[High] | Appendix; germinal center cells[High] | 3 | 0.011030 | 8 |
| HPA | HPA:0271111 | Kidney; bowman's capsule[≥Low] | Kidney; bowman's capsule[≥Low] | 4 | 0.012911 | 8 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 9 | 0.014590 | 8 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 6 | 0.015782 | 8 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 5 | 0.017309 | 8 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 5 | 0.017742 | 8 |
| HPA | HPA:0461452 | Skin 1; hair follicles[≥Medium] | Skin 1; hair follicles[≥Medium] | 4 | 0.017982 | 8 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 7 | 0.019594 | 8 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 5 | 0.019878 | 8 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 5 | 0.020038 | 8 |
| HPA | HPA:0271133 | Kidney; distal tubules[High] | Kidney; distal tubules[High] | 4 | 0.022083 | 8 |
| HPA | HPA:0340453 | Ovary; follicle cells[High] | Ovary; follicle cells[High] | 5 | 0.024933 | 8 |
| HPA | HPA:0360053 | Parathyroid gland; glandular cells[High] | Parathyroid gland; glandular cells[High] | 7 | 0.027368 | 8 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 5 | 0.028327 | 8 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 5 | 0.028749 | 8 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 5 | 0.030263 | 8 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 5 | 0.031382 | 8 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 5 | 0.033714 | 8 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 11 | 0.035647 | 8 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 6 | 0.035674 | 8 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 5 | 0.039048 | 8 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 8 | 0.039421 | 8 |
| HPA | HPA:0461451 | Skin 1; hair follicles[≥Low] | Skin 1; hair follicles[≥Low] | 4 | 0.042773 | 8 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 5 | 0.043530 | 8 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 11 | 0.047202 | 8 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 5 | 0.047769 | 8 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 10 | 0.047820 | 8 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 5 | 0.048717 | 8 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002151 | Increased circulating lactate concentration | Abnormally increased level of blood lactate (2-hydroxypropanoic acid). Lactate is produced from pyruvate by lactate dehydrogenase during normal metabolism. The terms lactate and lactic acid are often used interchangeably but lactate (the component measured in blood) is strictly a weak base whereas lactic acid is the corresponding acid. Lactic acidosis is often used clinically to describe elevated lactate but should be reserved for cases where there is a corresponding acidosis (pH below 7.35). | 5 | 0.000704 | 8 |
| HP | HP:0001941 | Acidosis | Abnormal acid accumulation or depletion of base. | 5 | 0.017302 | 8 |
| HP | HP:0004360 | Abnormality of acid-base homeostasis | An abnormality of the balance or maintenance of the balance of acids and bases in bodily fluids, resulting in an abnormal pH. | 5 | 0.024644 | 8 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000960 | regulation of mitochondrial RNA catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] | 2 | 0.003824 | 8 |
| GO:BP | GO:0000957 | mitochondrial RNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] | 2 | 0.005735 | 8 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9836573 | Mitochondrial RNA degradation | Mitochondrial RNA degradation | 2 | 0.007327 | 8 |
| REAC | REAC:R-HSA-9837999 | Mitochondrial protein degradation | Mitochondrial protein degradation | 3 | 0.021582 | 8 |
| REAC | REAC:R-HSA-611105 | Respiratory electron transport | Respiratory electron transport | 3 | 0.032124 | 8 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00062 | Fatty acid elongation | Fatty acid elongation | 2 | 0.009846 | 8 |
| KEGG | KEGG:01040 | Biosynthesis of unsaturated fatty acids | Biosynthesis of unsaturated fatty acids | 2 | 0.009846 | 8 |
| KEGG | KEGG:04913 | Ovarian steroidogenesis | Ovarian steroidogenesis | 2 | 0.035430 | 8 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4723 | Omega 3 omega 6 fatty acid synthesis | Omega 3 omega 6 fatty acid synthesis | 2 | 0.016235 | 8 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047617 | fatty acyl-CoA hydrolase activity | "Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+." [RHEA:16781] | 2 | 0.019697 | 8 |
| GO:MF | GO:0016289 | acyl-CoA hydrolase activity | "Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+." [RHEA:70423] | 2 | 0.021403 | 8 |
Community 9
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 10 | 3.307285e-21 | 9 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 10 | 3.307285e-21 | 9 |
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 7 | 4.668209e-14 | 9 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 10 | 3.217318e-12 | 9 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 11 | 1.036274e-11 | 9 |
| GO:MF | GO:0016772 | transferase activity, transferring phosphorus-containing groups | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] | 11 | 6.164714e-11 | 9 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 10 | 1.009911e-10 | 9 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 10 | 4.166717e-10 | 9 |
| GO:MF | GO:0019887 | protein kinase regulator activity | "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] | 7 | 5.066097e-09 | 9 |
| GO:MF | GO:0019207 | kinase regulator activity | "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] | 7 | 1.422942e-08 | 9 |
| GO:MF | GO:0016740 | transferase activity | "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-] | 11 | 3.546134e-07 | 9 |
| GO:MF | GO:0030332 | cyclin binding | "Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] | 4 | 7.252401e-07 | 9 |
| GO:MF | GO:0030295 | protein kinase activator activity | "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] | 5 | 2.006906e-06 | 9 |
| GO:MF | GO:0019209 | kinase activator activity | "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] | 5 | 2.687234e-06 | 9 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 7 | 1.027455e-05 | 9 |
| GO:MF | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity | "Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810] | 3 | 1.287806e-05 | 9 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 7 | 2.104463e-05 | 9 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 10 | 3.368692e-05 | 9 |
| GO:MF | GO:0019912 | cyclin-dependent protein kinase activating kinase activity | "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)." [GOC:go_curators] | 2 | 7.188510e-05 | 9 |
| GO:MF | GO:0030234 | enzyme regulator activity | "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 7 | 7.171667e-04 | 9 |
| GO:MF | GO:0098772 | molecular function regulator activity | "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt] | 8 | 1.393375e-03 | 9 |
| GO:MF | GO:0043539 | protein serine/threonine kinase activator activity | "Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators] | 3 | 1.819950e-03 | 9 |
| GO:MF | GO:0008047 | enzyme activator activity | "Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 5 | 3.622078e-03 | 9 |
| GO:MF | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr] | 2 | 4.728816e-03 | 9 |
| GO:MF | GO:0140677 | molecular function activator activity | "A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators] | 6 | 5.802561e-03 | 9 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 11 | 1.162193e-02 | 9 |
| GO:MF | GO:0031072 | heat shock protein binding | "Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw] | 3 | 1.245765e-02 | 9 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 7 | 1.441594e-02 | 9 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 9 | 8.217642e-20 | 9 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 9 | 6.793368e-17 | 9 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 9 | 1.649638e-16 | 9 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 11 | 5.712228e-14 | 9 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 9 | 1.627752e-13 | 9 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 11 | 9.379560e-11 | 9 |
| GO:CC | GO:0097125 | cyclin B1-CDK1 complex | "A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 2.411133e-05 | 9 |
| GO:CC | GO:0031461 | cullin-RING ubiquitin ligase complex | "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] | 4 | 1.776094e-04 | 9 |
| GO:CC | GO:0019005 | SCF ubiquitin ligase complex | "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] | 3 | 4.208538e-04 | 9 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 11 | 1.375116e-03 | 9 |
| GO:CC | GO:0000151 | ubiquitin ligase complex | "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] | 4 | 1.452969e-03 | 9 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 9 | 1.356165e-02 | 9 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 8 | 1.871469e-02 | 9 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 4 | 3.748603e-02 | 9 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 5 | 4.061453e-02 | 9 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 10 | 8.982524e-13 | 9 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 10 | 8.000854e-12 | 9 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 12 | 7.406621e-11 | 9 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 11 | 9.851485e-11 | 9 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 10 | 2.333292e-10 | 9 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 10 | 1.408284e-09 | 9 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 8 | 4.965904e-08 | 9 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 10 | 5.111391e-08 | 9 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 8 | 5.010620e-07 | 9 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 6 | 8.241492e-07 | 9 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 6 | 1.799950e-06 | 9 |
| GO:BP | GO:0048144 | fibroblast proliferation | "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] | 5 | 3.366870e-06 | 9 |
| GO:BP | GO:0000086 | G2/M transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] | 5 | 1.149090e-05 | 9 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 6 | 1.480083e-05 | 9 |
| GO:BP | GO:0044839 | cell cycle G2/M phase transition | "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle] | 5 | 2.052676e-05 | 9 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 6 | 7.236136e-05 | 9 |
| GO:BP | GO:0010389 | regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565] | 4 | 3.613216e-04 | 9 |
| GO:BP | GO:1905178 | regulation of cardiac muscle tissue regeneration | "Any process that modulates the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] | 2 | 3.828130e-04 | 9 |
| GO:BP | GO:1905179 | negative regulation of cardiac muscle tissue regeneration | "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] | 2 | 3.828130e-04 | 9 |
| GO:BP | GO:1902749 | regulation of cell cycle G2/M phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 4 | 5.777414e-04 | 9 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 6 | 1.568168e-03 | 9 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 5 | 1.652273e-03 | 9 |
| GO:BP | GO:0006468 | protein phosphorylation | "The process of introducing a phosphate group on to a protein." [GOC:hb] | 7 | 1.775173e-03 | 9 |
| GO:BP | GO:0045740 | positive regulation of DNA replication | "Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators] | 3 | 2.218407e-03 | 9 |
| GO:BP | GO:1905448 | positive regulation of mitochondrial ATP synthesis coupled electron transport | "Any process that activates or increases the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074] | 2 | 2.295421e-03 | 9 |
| GO:BP | GO:0016310 | phosphorylation | "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] | 7 | 2.904221e-03 | 9 |
| GO:BP | GO:0008283 | cell population proliferation | "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] | 8 | 3.128811e-03 | 9 |
| GO:BP | GO:0000280 | nuclear division | "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] | 5 | 4.025597e-03 | 9 |
| GO:BP | GO:1905446 | regulation of mitochondrial ATP synthesis coupled electron transport | "Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074] | 2 | 5.734915e-03 | 9 |
| GO:BP | GO:0061026 | cardiac muscle tissue regeneration | "The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:dph] | 2 | 5.734915e-03 | 9 |
| GO:BP | GO:0048285 | organelle fission | "The creation of two or more organelles by division of one organelle." [GOC:jid] | 5 | 6.592355e-03 | 9 |
| GO:BP | GO:0045930 | negative regulation of mitotic cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 7.575042e-03 | 9 |
| GO:BP | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] | 3 | 1.459440e-02 | 9 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 4 | 1.872730e-02 | 9 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 4 | 2.089733e-02 | 9 |
| GO:BP | GO:1901992 | positive regulation of mitotic cell cycle phase transition | "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 3 | 2.295468e-02 | 9 |
| GO:BP | GO:0048640 | negative regulation of developmental growth | "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators] | 3 | 2.446888e-02 | 9 |
| GO:BP | GO:0048638 | regulation of developmental growth | "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] | 4 | 2.679083e-02 | 9 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] | 4 | 3.588664e-02 | 9 |
| GO:BP | GO:0051169 | nuclear transport | "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] | 4 | 3.588664e-02 | 9 |
| GO:BP | GO:1901989 | positive regulation of cell cycle phase transition | "Any process that activates or increases the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 3 | 4.225000e-02 | 9 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 8 | 4.257171e-02 | 9 |
| GO:BP | GO:0045787 | positive regulation of cell cycle | "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] | 4 | 4.358001e-02 | 9 |
| GO:BP | GO:0006275 | regulation of DNA replication | "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] | 3 | 4.924899e-02 | 9 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 7 | 5.712120e-11 | 9 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 7 | 1.365815e-10 | 9 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 5 | 1.583459e-08 | 9 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 5 | 1.583459e-08 | 9 |
| REAC | REAC:R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | TP53 Regulates Transcription of Cell Cycle Genes | 5 | 1.967546e-08 | 9 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 5 | 5.621131e-08 | 9 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 5 | 2.794203e-07 | 9 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 5 | 3.160059e-07 | 9 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 7 | 1.419672e-06 | 9 |
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4 | 1.672586e-06 | 9 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 4 | 2.094728e-06 | 9 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 7 | 6.262579e-06 | 9 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 6 | 7.664594e-06 | 9 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 5 | 8.784122e-06 | 9 |
| REAC | REAC:R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 3 | 2.286747e-05 | 9 |
| REAC | REAC:R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 3 | 4.267576e-05 | 9 |
| REAC | REAC:R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 3 | 4.267576e-05 | 9 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 5 | 1.584267e-04 | 9 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 4 | 2.127352e-04 | 9 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 7 | 3.964537e-04 | 9 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 7 | 7.560754e-04 | 9 |
| REAC | REAC:R-HSA-69478 | G2/M DNA replication checkpoint | G2/M DNA replication checkpoint | 2 | 1.155028e-03 | 9 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 7 | 1.652958e-03 | 9 |
| REAC | REAC:R-HSA-176417 | Phosphorylation of Emi1 | Phosphorylation of Emi1 | 2 | 1.731912e-03 | 9 |
| REAC | REAC:R-HSA-8849470 | PTK6 Regulates Cell Cycle | PTK6 Regulates Cell Cycle | 2 | 1.731912e-03 | 9 |
| REAC | REAC:R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 2 | 2.423795e-03 | 9 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 3 | 2.824160e-03 | 9 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 3 | 2.824160e-03 | 9 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 3 | 3.090883e-03 | 9 |
| REAC | REAC:R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | E2F-enabled inhibition of pre-replication complex formation | 2 | 4.152057e-03 | 9 |
| REAC | REAC:R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | The role of GTSE1 in G2/M progression after G2 checkpoint | 3 | 4.858844e-03 | 9 |
| REAC | REAC:R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | DNA Damage/Telomere Stress Induced Senescence | 3 | 4.858844e-03 | 9 |
| REAC | REAC:R-HSA-2465910 | MASTL Facilitates Mitotic Progression | MASTL Facilitates Mitotic Progression | 2 | 5.188184e-03 | 9 |
| REAC | REAC:R-HSA-2514853 | Condensation of Prometaphase Chromosomes | Condensation of Prometaphase Chromosomes | 2 | 6.338808e-03 | 9 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 3 | 6.721759e-03 | 9 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 3 | 6.721759e-03 | 9 |
| REAC | REAC:R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2 | 8.983045e-03 | 9 |
| REAC | REAC:R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2 | 8.983045e-03 | 9 |
| REAC | REAC:R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | Golgi Cisternae Pericentriolar Stack Reorganization | 2 | 8.983045e-03 | 9 |
| REAC | REAC:R-HSA-4419969 | Depolymerization of the Nuclear Lamina | Depolymerization of the Nuclear Lamina | 2 | 8.983045e-03 | 9 |
| REAC | REAC:R-HSA-198323 | AKT phosphorylates targets in the cytosol | AKT phosphorylates targets in the cytosol | 2 | 1.047641e-02 | 9 |
| REAC | REAC:R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | Initiation of Nuclear Envelope (NE) Reformation | 2 | 1.380500e-02 | 9 |
| REAC | REAC:R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | FOXO-mediated transcription of cell cycle genes | 2 | 1.563997e-02 | 9 |
| REAC | REAC:R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2 | 1.758857e-02 | 9 |
| REAC | REAC:R-HSA-176412 | Phosphorylation of the APC/C | Phosphorylation of the APC/C | 2 | 2.182613e-02 | 9 |
| REAC | REAC:R-HSA-113510 | E2F mediated regulation of DNA replication | E2F mediated regulation of DNA replication | 2 | 2.903151e-02 | 9 |
| REAC | REAC:R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | APC/C:Cdc20 mediated degradation of Cyclin B | 2 | 3.165922e-02 | 9 |
| REAC | REAC:R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | Constitutive Signaling by AKT1 E17K in Cancer | 2 | 3.439968e-02 | 9 |
| REAC | REAC:R-HSA-1538133 | G0 and Early G1 | G0 and Early G1 | 2 | 3.725276e-02 | 9 |
| REAC | REAC:R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | Cyclin A/B1/B2 associated events during G2/M transition | 2 | 3.725276e-02 | 9 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 2 | 4.021835e-02 | 9 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP707 | DNA damage response | DNA damage response | 6 | 5.227092e-09 | 9 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 6 | 7.410962e-09 | 9 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 6 | 2.513912e-08 | 9 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 6 | 1.560942e-07 | 9 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 5 | 5.796203e-07 | 9 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 5 | 4.339692e-06 | 9 |
| WP | WP:WP2516 | ATM signaling | ATM signaling | 4 | 7.394224e-06 | 9 |
| WP | WP:WP5497 | Cyclin dependent kinase 4 6 inhibitors in breast cancer | Cyclin dependent kinase 4 6 inhibitors in breast cancer | 3 | 1.177044e-03 | 9 |
| WP | WP:WP1971 | Integrated cancer pathway | Integrated cancer pathway | 3 | 1.841231e-03 | 9 |
| WP | WP:WP1545 | miRNAs involved in DNA damage response | miRNAs involved in DNA damage response | 3 | 6.867398e-03 | 9 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 3 | 1.203346e-02 | 9 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 5 | 1.644861e-02 | 9 |
| WP | WP:WP4970 | Galanin receptor pathway | Galanin receptor pathway | 2 | 1.854300e-02 | 9 |
| WP | WP:WP3640 | Imatinib and chronic myeloid leukemia | Imatinib and chronic myeloid leukemia | 2 | 2.928823e-02 | 9 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 3 | 3.122490e-02 | 9 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 6 | 1.715895e-08 | 9 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 6 | 4.424777e-07 | 9 |
| KEGG | KEGG:04115 | p53 signaling pathway | p53 signaling pathway | 4 | 6.604265e-05 | 9 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 5 | 9.970888e-05 | 9 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 6 | 5.805059e-04 | 9 |
| KEGG | KEGG:04068 | FoxO signaling pathway | FoxO signaling pathway | 4 | 6.509900e-04 | 9 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 4 | 6.509900e-04 | 9 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 4 | 1.267607e-03 | 9 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 4 | 3.321308e-03 | 9 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 3 | 1.006400e-02 | 9 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | Progesterone-mediated oocyte maturation | 3 | 1.168354e-02 | 9 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 3 | 3.500540e-02 | 9 |
| KEGG | KEGG:04934 | Cushing syndrome | Cushing syndrome | 3 | 3.857981e-02 | 9 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3015 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | 3 | 0.000012 | 9 |
| CORUM | CORUM:6300 | CDKN1A-TP53-CDK1-PCNA complex | CDKN1A-TP53-CDK1-PCNA complex | 2 | 0.001265 | 9 |
| CORUM | CORUM:313 | Cell cycle kinase complex CDK5 | Cell cycle kinase complex CDK5 | 2 | 0.001265 | 9 |
| CORUM | CORUM:310 | Cell cycle kinase complex CDC2 | Cell cycle kinase complex CDC2 | 2 | 0.002527 | 9 |
| CORUM | CORUM:3036 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) | 2 | 0.004207 | 9 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0100522 | Thymoma | A tumor originating from the epithelial cells of the thymus. | 2 | 0.004006 | 9 |
| HP | HP:0011759 | Pituitary gonadotropic cell adenoma | A type of pituitary adenoma that produces gonadotropins. | 2 | 0.004006 | 9 |
| HP | HP:0011761 | Pituitary null cell adenoma | A type of pituitary adenoma that is of unknown cellular origin and that lacks immunocytochemical or fine structural markers. Null cell adenomas are not associated with hormone excess. | 2 | 0.004006 | 9 |
| HP | HP:0011762 | Pituitary thyrotropic cell adenoma | A type of pituitary adenoma that produces thyroid stimulating hormone (TSH). | 2 | 0.004006 | 9 |
| HP | HP:0040306 | Decreased male libido | Reduced desire for sexual activity on the part of a male. | 2 | 0.004006 | 9 |
| HP | HP:0500167 | Hypergastrinemia | An elevated amount of gastrin in the blood. | 2 | 0.006008 | 9 |
| HP | HP:0005605 | Large cafe-au-lait macules with irregular margins | Large hypermelanotic macules with jagged borders. | 2 | 0.006008 | 9 |
| HP | HP:0100521 | Neoplasm of the thymus | A tumor (abnormal growth of tissue) of the thymus. | 2 | 0.006008 | 9 |
| HP | HP:0500166 | Abnormal circulating gastrin concentration | An abnormal concentration of gastrin in the blood. | 2 | 0.006008 | 9 |
| HP | HP:0006723 | Intestinal carcinoid | Intestinal carcinoid | 2 | 0.006008 | 9 |
| HP | HP:0012197 | Insulinoma | A type of tumor of the pancreatic beta cells that secretes excess insulin and can result in hypoglycemia. | 2 | 0.006008 | 9 |
| HP | HP:0030404 | Glucagonoma | An endocrine tumor of the pancreas that secretes excessive amounts of glucagon. | 2 | 0.006008 | 9 |
| HP | HP:0006780 | Parathyroid carcinoma | A malignancy of the parathyroid glands. Parathyroid carcinoma usually secretes parathyroid hormone, leading to hyperparathyroidism. | 2 | 0.008409 | 9 |
| HP | HP:0030445 | Pulmonary carcinoid tumor | A malignant neuroendocrine tumor of the lung. According to histopathologic criteria (WHO 2004), carcinoids are divided into four groups i.e. typical and atypical carcinoids, large cell neuroendocrine carcinoma and small cell lung carcinoma. | 2 | 0.011209 | 9 |
| HP | HP:0006767 | Pituitary prolactin cell adenoma | A type of pituitary adenoma originating in prolactin secreting cells. This kind of adenoma is characterized by overproduction of prolactin, and may cause loss of menstrual periods and breast milk production in women. | 2 | 0.011209 | 9 |
| HP | HP:0008261 | Pancreatic islet cell adenoma | The presence of an adenoma of the pancreas with origin in a pancreatic B cell. | 2 | 0.014407 | 9 |
| HP | HP:0007449 | Confetti-like hypopigmented macules | Confetti-like hypopigmented macules | 2 | 0.014407 | 9 |
| HP | HP:0001579 | Primary hypercortisolism | Hypercortisolemia associated with a primary defect of the adrenal gland leading to overproduction of cortisol. | 2 | 0.014407 | 9 |
| HP | HP:0002044 | Zollinger-Ellison syndrome | A condition in which there is increased production of gastrin by a gastrin-secreting tumor (usually located in the pancreas, duodenum, or abdominal lymph nodes) that stimulates the gastric mucosa to maximal activity, with consequent gastrointestinal mucosal ulceration. | 2 | 0.014407 | 9 |
| HP | HP:0100829 | Galactorrhea | Spontaneous flow of milk from the breast, unassociated with childbirth or nursing. | 2 | 0.018005 | 9 |
| HP | HP:0032044 | Decreased vigilance | A decrease in the ability to maintain sustained attention is characterized by reduced alertness. | 2 | 0.018005 | 9 |
| HP | HP:0031094 | Abnormal breast physiology | Any anomaly of the function of the breast. | 2 | 0.018005 | 9 |
| HP | HP:0008208 | Parathyroid hyperplasia | Hyperplasia of the parathyroid gland. | 2 | 0.018005 | 9 |
| HP | HP:0000849 | Adrenocortical abnormality | Adrenocortical abnormality | 2 | 0.026393 | 9 |
| HP | HP:0002588 | Duodenal ulcer | An erosion of the mucous membrane in a portion of the duodenum. | 2 | 0.026393 | 9 |
| HP | HP:0100570 | Carcinoid tumor | A tumor formed from the endocrine (argentaffin) cells of the mucosal lining of a variety of organs including the stomach and intestine. These cells are from neuroectodermal origin. | 2 | 0.026393 | 9 |
| HP | HP:0012232 | Shortened QT interval | Decreased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG). | 2 | 0.031183 | 9 |
| HP | HP:0008291 | Pituitary corticotropic cell adenoma | A type of pituitary adenoma that produces adrenocorticotropic hormone (ACTH). | 2 | 0.031183 | 9 |
| HP | HP:0030405 | Pancreatic endocrine tumor | A neuroendocrine tumor originating in a hormone-producing cell (islet cell) of the pancreas. | 2 | 0.031183 | 9 |
| HP | HP:0046504 | Decreased libido | Decreased sexual desire. | 2 | 0.031183 | 9 |
| HP | HP:0003144 | Increased serum serotonin | A increased concentration of serotonin in the blood. | 2 | 0.031183 | 9 |
| HP | HP:0008200 | Primary hyperparathyroidism | A type of hyperparathyroidism caused by a primary abnormality of the parathyroid glands (e.g., adenoma, carcinoma, hyperplasia). Primary hyperparathyroidism is associated with hyercalcemia. | 2 | 0.036371 | 9 |
| HP | HP:0011407 | Proportionate tall stature | Proportionate tall stature | 2 | 0.041955 | 9 |
| HP | HP:0000845 | Elevated circulating growth hormone concentration | Acromegaly is a condition resulting from overproduction of growth hormone by the pituitary gland in persons with closed epiphyses, and consists chiefly in the enlargement of the distal parts of the body. The circumference of the skull increases, the nose becomes broad, the tongue becomes enlarged, the facial features become coarsened, the mandible grows excessively, and the teeth become separated. The fingers and toes grow chiefly in thickness. | 2 | 0.047936 | 9 |
Community 10
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000502 | proteasome complex | "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome] | 9 | 1.336912e-20 | 10 |
| GO:CC | GO:1905369 | endopeptidase complex | "A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 9 | 6.520535e-19 | 10 |
| GO:CC | GO:1905368 | peptidase complex | "A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 9 | 6.866303e-18 | 10 |
| GO:CC | GO:0005838 | proteasome regulatory particle | "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 6 | 1.055094e-14 | 10 |
| GO:CC | GO:0022624 | proteasome accessory complex | "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu] | 6 | 2.503186e-14 | 10 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 9 | 4.852087e-10 | 10 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 9 | 1.401852e-07 | 10 |
| GO:CC | GO:0008541 | proteasome regulatory particle, lid subcomplex | "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb] | 3 | 4.100470e-07 | 10 |
| GO:CC | GO:0008540 | proteasome regulatory particle, base subcomplex | "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 3 | 1.609372e-06 | 10 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 10 | 7.508826e-06 | 10 |
| GO:CC | GO:0005839 | proteasome core complex | "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] | 3 | 1.292169e-05 | 10 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 4 | 2.117909e-05 | 10 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 4 | 1.029868e-04 | 10 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 10 | 1.042391e-04 | 10 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 10 | 1.053758e-04 | 10 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 9 | 2.020928e-04 | 10 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 10 | 7.010648e-04 | 10 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 10 | 7.010648e-04 | 10 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 10 | 7.010648e-04 | 10 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 7 | 7.246139e-04 | 10 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 7 | 7.968671e-04 | 10 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 7 | 7.993766e-04 | 10 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 7 | 7.993766e-04 | 10 |
| GO:CC | GO:0019773 | proteasome core complex, alpha-subunit complex | "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779] | 2 | 9.115094e-04 | 10 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 4 | 9.622685e-04 | 10 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 4 | 1.022422e-03 | 10 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 4 | 1.034780e-03 | 10 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 8 | 6.357368e-03 | 10 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 7 | 1.460541e-02 | 10 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 6 | 3.606978e-02 | 10 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 6 | 3.654390e-02 | 10 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 10 | 4.197363e-02 | 10 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | Cross-presentation of soluble exogenous antigens (endosomes) | 9 | 8.657651e-19 | 10 |
| REAC | REAC:R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | Regulation of activated PAK-2p34 by proteasome mediated degradation | 9 | 1.055724e-18 | 10 |
| REAC | REAC:R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | Regulation of ornithine decarboxylase (ODC) | 9 | 1.281846e-18 | 10 |
| REAC | REAC:R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 9 | 1.550012e-18 | 10 |
| REAC | REAC:R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | Ubiquitin-dependent degradation of Cyclin D | 9 | 1.550012e-18 | 10 |
| REAC | REAC:R-HSA-180534 | Vpu mediated degradation of CD4 | Vpu mediated degradation of CD4 | 9 | 1.550012e-18 | 10 |
| REAC | REAC:R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 9 | 1.550012e-18 | 10 |
| REAC | REAC:R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | Autodegradation of the E3 ubiquitin ligase COP1 | 9 | 1.550012e-18 | 10 |
| REAC | REAC:R-HSA-69610 | p53-Independent DNA Damage Response | p53-Independent DNA Damage Response | 9 | 1.550012e-18 | 10 |
| REAC | REAC:R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint | p53-Independent G1/S DNA damage checkpoint | 9 | 1.550012e-18 | 10 |
| REAC | REAC:R-HSA-169911 | Regulation of Apoptosis | Regulation of Apoptosis | 9 | 1.866906e-18 | 10 |
| REAC | REAC:R-HSA-180585 | Vif-mediated degradation of APOBEC3G | Vif-mediated degradation of APOBEC3G | 9 | 1.866906e-18 | 10 |
| REAC | REAC:R-HSA-9604323 | Negative regulation of NOTCH4 signaling | Negative regulation of NOTCH4 signaling | 9 | 1.866906e-18 | 10 |
| REAC | REAC:R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | AUF1 (hnRNP D0) binds and destabilizes mRNA | 9 | 2.240103e-18 | 10 |
| REAC | REAC:R-HSA-4641257 | Degradation of AXIN | Degradation of AXIN | 9 | 2.678164e-18 | 10 |
| REAC | REAC:R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | SCF-beta-TrCP mediated degradation of Emi1 | 9 | 2.678164e-18 | 10 |
| REAC | REAC:R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 9 | 2.678164e-18 | 10 |
| REAC | REAC:R-HSA-9824272 | Somitogenesis | Somitogenesis | 9 | 2.678164e-18 | 10 |
| REAC | REAC:R-HSA-8941858 | Regulation of RUNX3 expression and activity | Regulation of RUNX3 expression and activity | 9 | 2.678164e-18 | 10 |
| REAC | REAC:R-HSA-5362768 | Hh mutants are degraded by ERAD | Hh mutants are degraded by ERAD | 9 | 3.190742e-18 | 10 |
| REAC | REAC:R-HSA-4641258 | Degradation of DVL | Degradation of DVL | 9 | 3.788695e-18 | 10 |
| REAC | REAC:R-HSA-69541 | Stabilization of p53 | Stabilization of p53 | 9 | 3.788695e-18 | 10 |
| REAC | REAC:R-HSA-351202 | Metabolism of polyamines | Metabolism of polyamines | 9 | 4.484209e-18 | 10 |
| REAC | REAC:R-HSA-5387390 | Hh mutants abrogate ligand secretion | Hh mutants abrogate ligand secretion | 9 | 5.290932e-18 | 10 |
| REAC | REAC:R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | NIK-->noncanonical NF-kB signaling | 9 | 5.290932e-18 | 10 |
| REAC | REAC:R-HSA-5610783 | Degradation of GLI2 by the proteasome | Degradation of GLI2 by the proteasome | 9 | 6.224114e-18 | 10 |
| REAC | REAC:R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | GLI3 is processed to GLI3R by the proteasome | 9 | 6.224114e-18 | 10 |
| REAC | REAC:R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | Dectin-1 mediated noncanonical NF-kB signaling | 9 | 6.224114e-18 | 10 |
| REAC | REAC:R-HSA-5610780 | Degradation of GLI1 by the proteasome | Degradation of GLI1 by the proteasome | 9 | 6.224114e-18 | 10 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 9 | 6.224114e-18 | 10 |
| REAC | REAC:R-HSA-5678895 | Defective CFTR causes cystic fibrosis | Defective CFTR causes cystic fibrosis | 9 | 7.300764e-18 | 10 |
| REAC | REAC:R-HSA-4608870 | Asymmetric localization of PCP proteins | Asymmetric localization of PCP proteins | 9 | 1.159154e-17 | 10 |
| REAC | REAC:R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | Autodegradation of Cdh1 by Cdh1:APC/C | 9 | 1.159154e-17 | 10 |
| REAC | REAC:R-HSA-5358346 | Hedgehog ligand biogenesis | Hedgehog ligand biogenesis | 9 | 1.345336e-17 | 10 |
| REAC | REAC:R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 9 | 1.557629e-17 | 10 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 9 | 1.557629e-17 | 10 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 9 | 1.557629e-17 | 10 |
| REAC | REAC:R-HSA-1169091 | Activation of NF-kappaB in B cells | Activation of NF-kappaB in B cells | 9 | 1.799182e-17 | 10 |
| REAC | REAC:R-HSA-5658442 | Regulation of RAS by GAPs | Regulation of RAS by GAPs | 9 | 1.799182e-17 | 10 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 9 | 2.073463e-17 | 10 |
| REAC | REAC:R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | APC/C:Cdc20 mediated degradation of Securin | 9 | 2.073463e-17 | 10 |
| REAC | REAC:R-HSA-9793380 | Formation of paraxial mesoderm | Formation of paraxial mesoderm | 9 | 2.384287e-17 | 10 |
| REAC | REAC:R-HSA-8948751 | Regulation of PTEN stability and activity | Regulation of PTEN stability and activity | 9 | 2.384287e-17 | 10 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 9 | 3.132722e-17 | 10 |
| REAC | REAC:R-HSA-8939902 | Regulation of RUNX2 expression and activity | Regulation of RUNX2 expression and activity | 9 | 3.132722e-17 | 10 |
| REAC | REAC:R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 9 | 4.083055e-17 | 10 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 9 | 4.083055e-17 | 10 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 9 | 4.648019e-17 | 10 |
| REAC | REAC:R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 9 | 4.648019e-17 | 10 |
| REAC | REAC:R-HSA-446652 | Interleukin-1 family signaling | Interleukin-1 family signaling | 10 | 4.816267e-17 | 10 |
| REAC | REAC:R-HSA-1234174 | Cellular response to hypoxia | Cellular response to hypoxia | 9 | 5.281405e-17 | 10 |
| REAC | REAC:R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | APC/C:Cdc20 mediated degradation of mitotic proteins | 9 | 5.990354e-17 | 10 |
| REAC | REAC:R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 9 | 6.782637e-17 | 10 |
| REAC | REAC:R-HSA-5619084 | ABC transporter disorders | ABC transporter disorders | 9 | 7.666698e-17 | 10 |
| REAC | REAC:R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | The role of GTSE1 in G2/M progression after G2 checkpoint | 9 | 8.651704e-17 | 10 |
| REAC | REAC:R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | Downstream signaling events of B Cell Receptor (BCR) | 9 | 9.747596e-17 | 10 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 9 | 1.096514e-16 | 10 |
| REAC | REAC:R-HSA-9013694 | Signaling by NOTCH4 | Signaling by NOTCH4 | 9 | 1.096514e-16 | 10 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 9 | 1.231600e-16 | 10 |
| REAC | REAC:R-HSA-195253 | Degradation of beta-catenin by the destruction complex | Degradation of beta-catenin by the destruction complex | 9 | 1.381275e-16 | 10 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 9 | 1.546901e-16 | 10 |
| REAC | REAC:R-HSA-5632684 | Hedgehog 'on' state | Hedgehog 'on' state | 9 | 1.729944e-16 | 10 |
| REAC | REAC:R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | Regulation of mRNA stability by proteins that bind AU-rich elements | 9 | 1.931986e-16 | 10 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 9 | 2.400007e-16 | 10 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 9 | 2.400007e-16 | 10 |
| REAC | REAC:R-HSA-5687128 | MAPK6/MAPK4 signaling | MAPK6/MAPK4 signaling | 9 | 2.669788e-16 | 10 |
| REAC | REAC:R-HSA-1236974 | ER-Phagosome pathway | ER-Phagosome pathway | 9 | 2.966187e-16 | 10 |
| REAC | REAC:R-HSA-4086400 | PCP/CE pathway | PCP/CE pathway | 9 | 3.648079e-16 | 10 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 9 | 3.648079e-16 | 10 |
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 9 | 4.932812e-16 | 10 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 9 | 4.932812e-16 | 10 |
| REAC | REAC:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | CLEC7A (Dectin-1) signaling | 9 | 5.998795e-16 | 10 |
| REAC | REAC:R-HSA-202424 | Downstream TCR signaling | Downstream TCR signaling | 9 | 6.604870e-16 | 10 |
| REAC | REAC:R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | TNFR2 non-canonical NF-kB pathway | 9 | 7.982592e-16 | 10 |
| REAC | REAC:R-HSA-5689603 | UCH proteinases | UCH proteinases | 9 | 9.609993e-16 | 10 |
| REAC | REAC:R-HSA-382556 | ABC-family proteins mediated transport | ABC-family proteins mediated transport | 9 | 1.052923e-15 | 10 |
| REAC | REAC:R-HSA-1236975 | Antigen processing-Cross presentation | Antigen processing-Cross presentation | 9 | 1.260529e-15 | 10 |
| REAC | REAC:R-HSA-5610787 | Hedgehog 'off' state | Hedgehog 'off' state | 9 | 2.502609e-15 | 10 |
| REAC | REAC:R-HSA-9020702 | Interleukin-1 signaling | Interleukin-1 signaling | 9 | 2.502609e-15 | 10 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 9 | 3.746390e-15 | 10 |
| REAC | REAC:R-HSA-202403 | TCR signaling | TCR signaling | 9 | 4.380803e-15 | 10 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 9 | 4.732441e-15 | 10 |
| REAC | REAC:R-HSA-9755511 | KEAP1-NFE2L2 pathway | KEAP1-NFE2L2 pathway | 9 | 5.942690e-15 | 10 |
| REAC | REAC:R-HSA-9758941 | Gastrulation | Gastrulation | 9 | 6.403232e-15 | 10 |
| REAC | REAC:R-HSA-162909 | Host Interactions of HIV factors | Host Interactions of HIV factors | 9 | 7.420511e-15 | 10 |
| REAC | REAC:R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 9 | 8.578937e-15 | 10 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 9 | 9.895350e-15 | 10 |
| REAC | REAC:R-HSA-5621481 | C-type lectin receptors (CLRs) | C-type lectin receptors (CLRs) | 9 | 1.400372e-14 | 10 |
| REAC | REAC:R-HSA-2871837 | FCERI mediated NF-kB activation | FCERI mediated NF-kB activation | 9 | 1.400372e-14 | 10 |
| REAC | REAC:R-HSA-6807070 | PTEN Regulation | PTEN Regulation | 9 | 1.603141e-14 | 10 |
| REAC | REAC:R-HSA-68867 | Assembly of the pre-replicative complex | Assembly of the pre-replicative complex | 9 | 2.088517e-14 | 10 |
| REAC | REAC:R-HSA-3858494 | Beta-catenin independent WNT signaling | Beta-catenin independent WNT signaling | 9 | 2.228606e-14 | 10 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 9 | 3.062167e-14 | 10 |
| REAC | REAC:R-HSA-5358351 | Signaling by Hedgehog | Signaling by Hedgehog | 9 | 3.258750e-14 | 10 |
| REAC | REAC:R-HSA-69002 | DNA Replication Pre-Initiation | DNA Replication Pre-Initiation | 9 | 5.935291e-14 | 10 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 9 | 7.051523e-14 | 10 |
| REAC | REAC:R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | Signaling by the B Cell Receptor (BCR) | 9 | 7.463006e-14 | 10 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 9 | 9.330589e-14 | 10 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 9 | 1.160240e-13 | 10 |
| REAC | REAC:R-HSA-5619115 | Disorders of transmembrane transporters | Disorders of transmembrane transporters | 9 | 1.291276e-13 | 10 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 9 | 1.512524e-13 | 10 |
| REAC | REAC:R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | Fc epsilon receptor (FCERI) signaling | 9 | 2.058445e-13 | 10 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 9 | 2.640346e-13 | 10 |
| REAC | REAC:R-HSA-2467813 | Separation of Sister Chromatids | Separation of Sister Chromatids | 9 | 2.772871e-13 | 10 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 9 | 4.064649e-13 | 10 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 9 | 4.461312e-13 | 10 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 9 | 7.007940e-13 | 10 |
| REAC | REAC:R-HSA-9711123 | Cellular response to chemical stress | Cellular response to chemical stress | 9 | 7.649933e-13 | 10 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 9 | 1.032847e-12 | 10 |
| REAC | REAC:R-HSA-5689880 | Ub-specific processing proteases | Ub-specific processing proteases | 9 | 1.220739e-12 | 10 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 9 | 1.497936e-12 | 10 |
| REAC | REAC:R-HSA-68882 | Mitotic Anaphase | Mitotic Anaphase | 9 | 1.623608e-12 | 10 |
| REAC | REAC:R-HSA-2555396 | Mitotic Metaphase and Anaphase | Mitotic Metaphase and Anaphase | 9 | 1.689887e-12 | 10 |
| REAC | REAC:R-HSA-201681 | TCF dependent signaling in response to WNT | TCF dependent signaling in response to WNT | 9 | 1.829700e-12 | 10 |
| REAC | REAC:R-HSA-157118 | Signaling by NOTCH | Signaling by NOTCH | 9 | 1.829700e-12 | 10 |
| REAC | REAC:R-HSA-8878171 | Transcriptional regulation by RUNX1 | Transcriptional regulation by RUNX1 | 9 | 2.058712e-12 | 10 |
| REAC | REAC:R-HSA-8951664 | Neddylation | Neddylation | 9 | 3.017199e-12 | 10 |
| REAC | REAC:R-HSA-1257604 | PIP3 activates AKT signaling | PIP3 activates AKT signaling | 9 | 4.050347e-12 | 10 |
| REAC | REAC:R-HSA-449147 | Signaling by Interleukins | Signaling by Interleukins | 10 | 5.753150e-12 | 10 |
| REAC | REAC:R-HSA-5673001 | RAF/MAP kinase cascade | RAF/MAP kinase cascade | 9 | 6.632125e-12 | 10 |
| REAC | REAC:R-HSA-5684996 | MAPK1/MAPK3 signaling | MAPK1/MAPK3 signaling | 9 | 7.859011e-12 | 10 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 9 | 1.411686e-11 | 10 |
| REAC | REAC:R-HSA-9006925 | Intracellular signaling by second messengers | Intracellular signaling by second messengers | 9 | 1.550819e-11 | 10 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 9 | 1.866133e-11 | 10 |
| REAC | REAC:R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | Antigen processing: Ubiquitination & Proteasome degradation | 9 | 2.519558e-11 | 10 |
| REAC | REAC:R-HSA-5683057 | MAPK family signaling cascades | MAPK family signaling cascades | 9 | 2.672292e-11 | 10 |
| REAC | REAC:R-HSA-195721 | Signaling by WNT | Signaling by WNT | 9 | 4.341181e-11 | 10 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 9 | 1.120323e-10 | 10 |
| REAC | REAC:R-HSA-983169 | Class I MHC mediated antigen processing & presentation | Class I MHC mediated antigen processing & presentation | 9 | 1.696562e-10 | 10 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 9 | 3.159698e-10 | 10 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 9 | 6.944250e-10 | 10 |
| REAC | REAC:R-HSA-1280215 | Cytokine Signaling in Immune system | Cytokine Signaling in Immune system | 10 | 8.335997e-10 | 10 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 9 | 4.277676e-09 | 10 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 9 | 4.723407e-09 | 10 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 9 | 6.419400e-09 | 10 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 9 | 3.203125e-08 | 10 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 9 | 4.785387e-08 | 10 |
| REAC | REAC:R-HSA-382551 | Transport of small molecules | Transport of small molecules | 9 | 6.067378e-08 | 10 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 9 | 1.336446e-07 | 10 |
| REAC | REAC:R-HSA-1280218 | Adaptive Immune System | Adaptive Immune System | 9 | 1.562818e-07 | 10 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 9 | 1.562818e-07 | 10 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 9 | 3.059641e-07 | 10 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 9 | 1.768390e-06 | 10 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 9 | 2.421152e-06 | 10 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 9 | 6.754804e-06 | 10 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 9 | 1.554386e-05 | 10 |
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 10 | 1.610061e-05 | 10 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 9 | 1.876778e-05 | 10 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 9 | 2.857763e-05 | 10 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 9 | 4.268093e-05 | 10 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 10 | 1.248893e-04 | 10 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 9 | 2.382059e-04 | 10 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 9 | 6.474089e-04 | 10 |
| REAC | REAC:R-HSA-1430728 | Metabolism | Metabolism | 9 | 7.539699e-04 | 10 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03050 | Proteasome | Proteasome | 9 | 1.077390e-18 | 10 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | Spinocerebellar ataxia | 9 | 4.528035e-14 | 10 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 9 | 1.478608e-11 | 10 |
| KEGG | KEGG:05020 | Prion disease | Prion disease | 9 | 1.813067e-11 | 10 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 9 | 5.312928e-11 | 10 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis | 9 | 2.578444e-10 | 10 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 9 | 4.092911e-10 | 10 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 9 | 2.877918e-09 | 10 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 6 | 1.786241e-06 | 10 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP183 | Proteasome degradation | Proteasome degradation | 9 | 3.236280e-17 | 10 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 8 | 3.093103e-09 | 10 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 8 | 3.605961e-09 | 10 |
| WP | WP:WP2359 | Parkin ubiquitin proteasomal system pathway | Parkin ubiquitin proteasomal system pathway | 6 | 6.239943e-09 | 10 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:193 | PA700-20S-PA28 complex | PA700-20S-PA28 complex | 9 | 4.336617e-17 | 10 |
| CORUM | CORUM:32 | PA700 complex | PA700 complex | 6 | 2.765254e-10 | 10 |
| CORUM | CORUM:181 | 26S proteasome | 26S proteasome | 5 | 6.983664e-08 | 10 |
| CORUM | CORUM:191 | 20S proteasome | 20S proteasome | 3 | 3.784655e-04 | 10 |
| CORUM | CORUM:194 | PA28gamma-20S proteasome | PA28gamma-20S proteasome | 3 | 5.039480e-04 | 10 |
| CORUM | CORUM:192 | PA28-20S proteasome | PA28-20S proteasome | 3 | 6.542591e-04 | 10 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 9 | 4.664600e-12 | 10 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 9 | 5.440551e-11 | 10 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 9 | 2.024864e-10 | 10 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 9 | 2.335328e-10 | 10 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 9 | 2.505862e-10 | 10 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 9 | 1.533129e-09 | 10 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 9 | 1.747163e-08 | 10 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 9 | 3.059850e-07 | 10 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 9 | 4.684761e-07 | 10 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 9 | 7.880742e-05 | 10 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 10 | 3.758912e-04 | 10 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 4 | 2.096243e-02 | 10 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0036402 | proteasome-activating activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome." [GOC:rb, PMID:11430818] | 2 | 0.000594 | 10 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 10 | 0.036409 | 10 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 9 | 0.038774 | 10 |
Community 11
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 10 | 2.423201e-21 | 11 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 10 | 2.423201e-21 | 11 |
| REAC | REAC:R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 8 | 6.076344e-20 | 11 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 11 | 5.454676e-19 | 11 |
| REAC | REAC:R-HSA-1538133 | G0 and Early G1 | G0 and Early G1 | 8 | 1.471267e-17 | 11 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 10 | 1.340317e-16 | 11 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 9 | 7.472343e-16 | 11 |
| REAC | REAC:R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | Transcription of E2F targets under negative control by DREAM complex | 7 | 8.246678e-16 | 11 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 9 | 9.383787e-16 | 11 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 7 | 2.294596e-14 | 11 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 9 | 4.250108e-13 | 11 |
| REAC | REAC:R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 6 | 7.048666e-13 | 11 |
| REAC | REAC:R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 6 | 7.048666e-13 | 11 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 11 | 1.320530e-12 | 11 |
| REAC | REAC:R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | TP53 Regulates Transcription of Cell Cycle Genes | 7 | 2.204075e-12 | 11 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 11 | 1.394593e-11 | 11 |
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 6 | 1.101155e-10 | 11 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 6 | 1.559491e-10 | 11 |
| REAC | REAC:R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 5 | 8.931051e-10 | 11 |
| REAC | REAC:R-HSA-2559585 | Oncogene Induced Senescence | Oncogene Induced Senescence | 5 | 2.457089e-08 | 11 |
| REAC | REAC:R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 5 | 3.897587e-08 | 11 |
| REAC | REAC:R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 4 | 1.640997e-07 | 11 |
| REAC | REAC:R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5 | 2.176577e-07 | 11 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 10 | 9.177411e-07 | 11 |
| REAC | REAC:R-HSA-113510 | E2F mediated regulation of DNA replication | E2F mediated regulation of DNA replication | 4 | 1.445009e-06 | 11 |
| REAC | REAC:R-HSA-111448 | Activation of NOXA and translocation to mitochondria | Activation of NOXA and translocation to mitochondria | 3 | 2.263363e-06 | 11 |
| REAC | REAC:R-HSA-68911 | G2 Phase | G2 Phase | 3 | 2.263363e-06 | 11 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 10 | 2.320176e-06 | 11 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 7 | 3.337312e-06 | 11 |
| REAC | REAC:R-HSA-2559583 | Cellular Senescence | Cellular Senescence | 6 | 3.638555e-06 | 11 |
| REAC | REAC:R-HSA-1912408 | Pre-NOTCH Transcription and Translation | Pre-NOTCH Transcription and Translation | 5 | 4.955944e-06 | 11 |
| REAC | REAC:R-HSA-170834 | Signaling by TGF-beta Receptor Complex | Signaling by TGF-beta Receptor Complex | 5 | 4.955944e-06 | 11 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 10 | 7.141095e-06 | 11 |
| REAC | REAC:R-HSA-1912422 | Pre-NOTCH Expression and Processing | Pre-NOTCH Expression and Processing | 5 | 1.115165e-05 | 11 |
| REAC | REAC:R-HSA-139915 | Activation of PUMA and translocation to mitochondria | Activation of PUMA and translocation to mitochondria | 3 | 1.897080e-05 | 11 |
| REAC | REAC:R-HSA-9006936 | Signaling by TGFB family members | Signaling by TGFB family members | 5 | 2.060507e-05 | 11 |
| REAC | REAC:R-HSA-157118 | Signaling by NOTCH | Signaling by NOTCH | 5 | 4.961232e-04 | 11 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 3 | 9.064710e-04 | 11 |
| REAC | REAC:R-HSA-8953750 | Transcriptional Regulation by E2F6 | Transcriptional Regulation by E2F6 | 3 | 1.333125e-03 | 11 |
| REAC | REAC:R-HSA-2559580 | Oxidative Stress Induced Senescence | Oxidative Stress Induced Senescence | 4 | 1.362601e-03 | 11 |
| REAC | REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | Intrinsic Pathway for Apoptosis | 3 | 5.465820e-03 | 11 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 6 | 1.444490e-02 | 11 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 6 | 1.595059e-02 | 11 |
| REAC | REAC:R-HSA-9616222 | Transcriptional regulation of granulopoiesis | Transcriptional regulation of granulopoiesis | 3 | 2.293936e-02 | 11 |
| REAC | REAC:R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 2 | 2.504123e-02 | 11 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP179 | Cell cycle | Cell cycle | 11 | 2.665321e-19 | 11 |
| WP | WP:WP5180 | DYRK1A involvement regarding cell proliferation in brain development | DYRK1A involvement regarding cell proliferation in brain development | 7 | 2.690079e-11 | 11 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 7 | 3.728133e-10 | 11 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 6 | 7.127559e-09 | 11 |
| WP | WP:WP236 | Adipogenesis | Adipogenesis | 5 | 3.798843e-05 | 11 |
| WP | WP:WP3969 | H19 Rb E2F1 and CDK beta catenin in colorectal cancer | H19 Rb E2F1 and CDK beta catenin in colorectal cancer | 3 | 7.040707e-05 | 11 |
| WP | WP:WP53 | ID signaling | ID signaling | 3 | 1.081700e-04 | 11 |
| WP | WP:WP4685 | Melanoma | Melanoma | 4 | 1.392892e-04 | 11 |
| WP | WP:WP4255 | Non small cell lung cancer | Non small cell lung cancer | 4 | 1.755080e-04 | 11 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 4 | 3.937364e-04 | 11 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 4 | 5.351187e-04 | 11 |
| WP | WP:WP2431 | Spinal cord injury | Spinal cord injury | 4 | 1.147167e-03 | 11 |
| WP | WP:WP2828 | Bladder cancer | Bladder cancer | 3 | 1.877228e-03 | 11 |
| WP | WP:WP4262 | Breast cancer pathway | Breast cancer pathway | 4 | 3.646006e-03 | 11 |
| WP | WP:WP3611 | Photodynamic therapy induced AP 1 survival signaling | Photodynamic therapy induced AP 1 survival signaling | 3 | 3.698548e-03 | 11 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 3 | 9.758465e-03 | 11 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 3 | 1.155226e-02 | 11 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 3 | 1.203210e-02 | 11 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 3 | 1.634752e-02 | 11 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 5 | 2.857748e-02 | 11 |
| WP | WP:WP3998 | Prader Willi and Angelman syndrome | Prader Willi and Angelman syndrome | 3 | 3.701671e-02 | 11 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 3 | 4.230649e-02 | 11 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 11 | 3.588944e-18 | 11 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 9 | 5.609978e-13 | 11 |
| KEGG | KEGG:05219 | Bladder cancer | Bladder cancer | 4 | 8.851036e-06 | 11 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 6 | 7.591329e-05 | 11 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | Non-small cell lung cancer | 4 | 8.808736e-05 | 11 |
| KEGG | KEGG:05218 | Melanoma | Melanoma | 4 | 8.808736e-05 | 11 |
| KEGG | KEGG:05214 | Glioma | Glioma | 4 | 1.038626e-04 | 11 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 4 | 1.095600e-04 | 11 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 4 | 1.095600e-04 | 11 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 5 | 1.588700e-04 | 11 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 5 | 1.710989e-04 | 11 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 4 | 2.360848e-04 | 11 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 5 | 2.551692e-04 | 11 |
| KEGG | KEGG:01522 | Endocrine resistance | Endocrine resistance | 4 | 2.684494e-04 | 11 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 4 | 2.917810e-04 | 11 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | TGF-beta signaling pathway | 4 | 4.317041e-04 | 11 |
| KEGG | KEGG:05224 | Breast cancer | Breast cancer | 4 | 1.520895e-03 | 11 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 4 | 1.562099e-03 | 11 |
| KEGG | KEGG:04934 | Cushing syndrome | Cushing syndrome | 4 | 1.780585e-03 | 11 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 4 | 2.020797e-03 | 11 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 4 | 2.229500e-03 | 11 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 4 | 2.453648e-03 | 11 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 4 | 4.515954e-03 | 11 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | Human cytomegalovirus infection | 4 | 7.764051e-03 | 11 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 5 | 1.793631e-02 | 11 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 10 | 5.733578e-14 | 11 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 7 | 8.660388e-10 | 11 |
| GO:CC | GO:0035189 | Rb-E2F complex | "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073] | 3 | 3.918240e-08 | 11 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 9 | 8.488911e-08 | 11 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 11 | 1.399514e-06 | 11 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 9 | 1.970083e-06 | 11 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 11 | 2.558547e-05 | 11 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 11 | 1.971445e-04 | 11 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 11 | 1.974701e-04 | 11 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 11 | 2.057724e-04 | 11 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 11 | 2.057724e-04 | 11 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 11 | 2.057724e-04 | 11 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 3 | 4.824714e-04 | 11 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 11 | 1.375116e-03 | 11 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 3 | 4.136072e-03 | 11 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 3 | 5.505971e-03 | 11 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 7 | 8.531434e-03 | 11 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 11 | 1.855441e-02 | 11 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 5 | 4.061453e-02 | 11 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 8 | 1.270687e-11 | 11 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 8 | 3.639130e-11 | 11 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 8 | 5.401866e-09 | 11 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 8 | 3.076491e-08 | 11 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 6 | 6.685179e-08 | 11 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 6 | 1.761531e-07 | 11 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 8 | 4.493149e-07 | 11 |
| GO:BP | GO:0070345 | negative regulation of fat cell proliferation | "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] | 3 | 1.330728e-06 | 11 |
| GO:BP | GO:0043550 | regulation of lipid kinase activity | "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf] | 3 | 1.330728e-06 | 11 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 8 | 1.873036e-06 | 11 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 11 | 2.509609e-06 | 11 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 11 | 2.668068e-06 | 11 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 11 | 3.909776e-06 | 11 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 11 | 5.951725e-06 | 11 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 9 | 7.047501e-06 | 11 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 6 | 7.310991e-06 | 11 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 10 | 9.241987e-06 | 11 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 11 | 1.420473e-05 | 11 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 10 | 1.519792e-05 | 11 |
| GO:BP | GO:0070344 | regulation of fat cell proliferation | "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] | 3 | 1.594596e-05 | 11 |
| GO:BP | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 4 | 1.835357e-05 | 11 |
| GO:BP | GO:1902807 | negative regulation of cell cycle G1/S phase transition | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 4 | 2.604245e-05 | 11 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 8 | 3.229127e-05 | 11 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 6 | 3.589132e-05 | 11 |
| GO:BP | GO:0070341 | fat cell proliferation | "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl] | 3 | 6.037551e-05 | 11 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 6 | 8.325103e-05 | 11 |
| GO:BP | GO:1901988 | negative regulation of cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 5 | 1.195106e-04 | 11 |
| GO:BP | GO:0010948 | negative regulation of cell cycle process | "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 5 | 2.557855e-04 | 11 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 8 | 2.929091e-04 | 11 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 8 | 2.956073e-04 | 11 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 7 | 3.326101e-04 | 11 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 11 | 3.897310e-04 | 11 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 11 | 5.230732e-04 | 11 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 8 | 5.379103e-04 | 11 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 11 | 6.470611e-04 | 11 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 6 | 7.873377e-04 | 11 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 11 | 8.886356e-04 | 11 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 5 | 9.537625e-04 | 11 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 8 | 1.203566e-03 | 11 |
| GO:BP | GO:1901991 | negative regulation of mitotic cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 1.705676e-03 | 11 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 9 | 2.815304e-03 | 11 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 11 | 3.021380e-03 | 11 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 11 | 4.076063e-03 | 11 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 11 | 4.888040e-03 | 11 |
| GO:BP | GO:0045930 | negative regulation of mitotic cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 4.965446e-03 | 11 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 11 | 5.660511e-03 | 11 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 9 | 6.131470e-03 | 11 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] | 7 | 6.482962e-03 | 11 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 11 | 7.315282e-03 | 11 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 8 | 7.727590e-03 | 11 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 11 | 7.798511e-03 | 11 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 8 | 1.040393e-02 | 11 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 11 | 1.342630e-02 | 11 |
| GO:BP | GO:1901992 | positive regulation of mitotic cell cycle phase transition | "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 3 | 1.683960e-02 | 11 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 6 | 1.998550e-02 | 11 |
| GO:BP | GO:0008283 | cell population proliferation | "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] | 7 | 2.141167e-02 | 11 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 11 | 2.978126e-02 | 11 |
| GO:BP | GO:1901989 | positive regulation of cell cycle phase transition | "Any process that activates or increases the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 3 | 3.101792e-02 | 11 |
| GO:BP | GO:0045931 | positive regulation of mitotic cell cycle | "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 3 | 3.988923e-02 | 11 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2975 | SMAD3-E2F4/5-p107-DP1 complex | SMAD3-E2F4/5-p107-DP1 complex | 4 | 2.055245e-08 | 11 |
| CORUM | CORUM:1474 | SMAD3/4-E2F4/5-p107-DP1 complex | SMAD3/4-E2F4/5-p107-DP1 complex | 4 | 6.158435e-08 | 11 |
| CORUM | CORUM:1473 | E2F5-RB2-DP1 complex | E2F5-RB2-DP1 complex | 3 | 2.318320e-06 | 11 |
| CORUM | CORUM:1661 | E2F4-p107-cyclinA complex | E2F4-p107-cyclinA complex | 3 | 2.318320e-06 | 11 |
| CORUM | CORUM:5144 | E2F1-p107-cyclinA complex | E2F1-p107-cyclinA complex | 3 | 2.318320e-06 | 11 |
| CORUM | CORUM:5117 | RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2) | RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2) | 3 | 2.312151e-05 | 11 |
| CORUM | CORUM:5118 | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) | 3 | 4.618144e-05 | 11 |
| CORUM | CORUM:5159 | E2F4-p107-cyclinE complex | E2F4-p107-cyclinE complex | 2 | 1.119749e-03 | 11 |
| CORUM | CORUM:6588 | E2F-1-DP-1 complex | E2F-1-DP-1 complex | 2 | 1.119749e-03 | 11 |
| CORUM | CORUM:5160 | E2F4-p130 complex | E2F4-p130 complex | 2 | 1.119749e-03 | 11 |
| CORUM | CORUM:1250 | RB-E2F1 complex | RB-E2F1 complex | 2 | 1.119749e-03 | 11 |
| CORUM | CORUM:5143 | RB-E2F1 complex | RB-E2F1 complex | 2 | 1.119749e-03 | 11 |
| CORUM | CORUM:5099 | RB1(hypophosphorylated)-E2F4 complex | RB1(hypophosphorylated)-E2F4 complex | 2 | 1.119749e-03 | 11 |
| CORUM | CORUM:3900 | GABP(gamma)1-E2F1-DP1 complex | GABP(gamma)1-E2F1-DP1 complex | 2 | 3.354610e-03 | 11 |
| CORUM | CORUM:1488 | DNMT1-RB1-HDAC1-E2F1 complex | DNMT1-RB1-HDAC1-E2F1 complex | 2 | 3.354610e-03 | 11 |
| CORUM | CORUM:5656 | CEBPE-E2F1-RB1 complex | CEBPE-E2F1-RB1 complex | 2 | 3.354610e-03 | 11 |
| CORUM | CORUM:6589 | E2F-1-DP-1-cyclinA-CDK2 complex | E2F-1-DP-1-cyclinA-CDK2 complex | 2 | 3.354610e-03 | 11 |
| CORUM | CORUM:1471 | pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300) | pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300) | 2 | 1.115118e-02 | 11 |
| CORUM | CORUM:5596 | LINC complex, quiescent cells | LINC complex, quiescent cells | 2 | 1.670368e-02 | 11 |
| CORUM | CORUM:6444 | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex | 2 | 1.670368e-02 | 11 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] | 9 | 3.132255e-07 | 11 |
| GO:MF | GO:0000976 | transcription cis-regulatory region binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] | 9 | 5.746648e-07 | 11 |
| GO:MF | GO:0001067 | transcription regulatory region nucleic acid binding | "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] | 9 | 5.781115e-07 | 11 |
| GO:MF | GO:1990837 | sequence-specific double-stranded DNA binding | "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] | 9 | 8.263191e-07 | 11 |
| GO:MF | GO:0003690 | double-stranded DNA binding | "Binding to double-stranded DNA." [GOC:elh, GOC:vw] | 9 | 1.417168e-06 | 11 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 9 | 1.519642e-06 | 11 |
| GO:MF | GO:0001216 | DNA-binding transcription activator activity | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018] | 6 | 1.541797e-05 | 11 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 9 | 6.607829e-05 | 11 |
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 8 | 1.868793e-04 | 11 |
| GO:MF | GO:1990841 | promoter-specific chromatin binding | "Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729] | 3 | 1.168371e-03 | 11 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 5 | 2.731927e-03 | 11 |
| GO:MF | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018] | 6 | 6.233948e-03 | 11 |
| GO:MF | GO:0003700 | DNA-binding transcription factor activity | "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] | 6 | 8.910031e-03 | 11 |
| GO:MF | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] | 4 | 1.782340e-02 | 11 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 4 | 4.224755e-02 | 11 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 9 | 4.534438e-02 | 11 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-20a-5p | hsa-mir-20a-5p | hsa-mir-20a-5p | 7 | 0.000399 | 11 |
| MIRNA | MIRNA:hsa-mir-106b-5p | hsa-mir-106b-5p | hsa-mir-106b-5p | 7 | 0.000470 | 11 |
| MIRNA | MIRNA:hsa-mir-17-5p | hsa-mir-17-5p | hsa-mir-17-5p | 7 | 0.000768 | 11 |
| MIRNA | MIRNA:hsa-mir-24-3p | hsa-mir-24-3p | hsa-mir-24-3p | 6 | 0.001856 | 11 |
| MIRNA | MIRNA:hsa-mir-4746-3p | hsa-mir-4746-3p | hsa-mir-4746-3p | 4 | 0.013279 | 11 |
| MIRNA | MIRNA:hsa-mir-98-5p | hsa-mir-98-5p | hsa-mir-98-5p | 5 | 0.023494 | 11 |
| MIRNA | MIRNA:hsa-mir-141-3p | hsa-mir-141-3p | hsa-mir-141-3p | 3 | 0.044890 | 11 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 5 | 0.004677 | 11 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 5 | 0.007851 | 11 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 5 | 0.015149 | 11 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 5 | 0.016003 | 11 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 8 | 0.018730 | 11 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 5 | 0.024393 | 11 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 8 | 0.036009 | 11 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 8 | 0.040044 | 11 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 4 | 0.043291 | 11 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 5 | 0.044419 | 11 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11541_1 | Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN; match class: 1 | Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN; match class: 1 | 10 | 0.038223 | 11 |
| TF | TF:M00918 | Factor: E2F; motif: TTTSGCGSG | Factor: E2F; motif: TTTSGCGSG | 10 | 0.046125 | 11 |
Community 12
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-68962 | Activation of the pre-replicative complex | Activation of the pre-replicative complex | 10 | 4.336647e-23 | 12 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 11 | 1.354602e-19 | 12 |
| REAC | REAC:R-HSA-176187 | Activation of ATR in response to replication stress | Activation of ATR in response to replication stress | 9 | 3.195639e-19 | 12 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 11 | 5.454676e-19 | 12 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 11 | 7.750060e-18 | 12 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 10 | 5.884689e-17 | 12 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 9 | 1.902402e-16 | 12 |
| REAC | REAC:R-HSA-69002 | DNA Replication Pre-Initiation | DNA Replication Pre-Initiation | 10 | 9.884156e-16 | 12 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 10 | 1.197787e-15 | 12 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 9 | 2.211535e-15 | 12 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 10 | 4.387874e-13 | 12 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 9 | 5.621422e-13 | 12 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 11 | 1.320530e-12 | 12 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 11 | 1.394593e-11 | 12 |
| REAC | REAC:R-HSA-68867 | Assembly of the pre-replicative complex | Assembly of the pre-replicative complex | 8 | 3.070747e-11 | 12 |
| REAC | REAC:R-HSA-176974 | Unwinding of DNA | Unwinding of DNA | 5 | 8.278160e-11 | 12 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 5 | 8.380672e-09 | 12 |
| REAC | REAC:R-HSA-69190 | DNA strand elongation | DNA strand elongation | 5 | 2.085752e-08 | 12 |
| REAC | REAC:R-HSA-68689 | CDC6 association with the ORC:origin complex | CDC6 association with the ORC:origin complex | 3 | 1.265410e-05 | 12 |
| REAC | REAC:R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | E2F-enabled inhibition of pre-replication complex formation | 2 | 9.933477e-03 | 12 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP466 | DNA replication | DNA replication | 10 | 2.944036e-21 | 12 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 10 | 2.303371e-16 | 12 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 8 | 1.112899e-13 | 12 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 7 | 3.728133e-10 | 12 |
| WP | WP:WP4352 | Ciliary landscape | Ciliary landscape | 4 | 1.346413e-02 | 12 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006270 | DNA replication initiation | "The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641] | 9 | 3.861539e-21 | 12 |
| GO:BP | GO:0006261 | DNA-templated DNA replication | "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] | 10 | 6.689620e-18 | 12 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 10 | 2.262182e-15 | 12 |
| GO:BP | GO:0000727 | double-strand break repair via break-induced replication | "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855] | 5 | 1.334008e-11 | 12 |
| GO:BP | GO:0090329 | regulation of DNA-templated DNA replication | "Any process that modulates the rate, frequency, or extent of DNA-templated DNA replication, the process in which new strands of DNA are synthesized." [GOC:dph, GOC:tb] | 6 | 1.835649e-11 | 12 |
| GO:BP | GO:0033260 | nuclear DNA replication | "The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] | 6 | 2.149892e-11 | 12 |
| GO:BP | GO:0044786 | cell cycle DNA replication | "The DNA-dependent DNA replication that takes place as part of the cell cycle." [GOC:mtg_cell_cycle] | 6 | 3.891280e-11 | 12 |
| GO:BP | GO:0030174 | regulation of DNA-templated DNA replication initiation | "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah] | 5 | 5.054504e-11 | 12 |
| GO:BP | GO:0006275 | regulation of DNA replication | "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] | 7 | 6.686936e-11 | 12 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 10 | 7.847154e-10 | 12 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 9 | 5.416694e-09 | 12 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 9 | 2.725413e-08 | 12 |
| GO:BP | GO:1902969 | mitotic DNA replication | "Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] | 4 | 1.201725e-07 | 12 |
| GO:BP | GO:0000076 | DNA replication checkpoint signaling | "A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518] | 4 | 2.444413e-07 | 12 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 9 | 6.874763e-07 | 12 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 7 | 1.566837e-06 | 12 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 9 | 7.047501e-06 | 12 |
| GO:BP | GO:0000724 | double-strand break repair via homologous recombination | "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] | 5 | 2.995797e-05 | 12 |
| GO:BP | GO:0000725 | recombinational repair | "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] | 5 | 3.416630e-05 | 12 |
| GO:BP | GO:0006271 | DNA strand elongation involved in DNA replication | "The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication." [GOC:mah, ISBN:071673706X, ISBN:0815316194] | 3 | 6.037551e-05 | 12 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 6 | 1.322700e-04 | 12 |
| GO:BP | GO:0006302 | double-strand break repair | "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] | 5 | 4.174808e-04 | 12 |
| GO:BP | GO:0031570 | DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] | 4 | 4.456158e-04 | 12 |
| GO:BP | GO:0006310 | DNA recombination | "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] | 5 | 6.331605e-04 | 12 |
| GO:BP | GO:0071163 | DNA replication preinitiation complex assembly | "The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins as part of initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity." [GOC:mah, PMID:28209641] | 2 | 9.328404e-04 | 12 |
| GO:BP | GO:0022616 | DNA strand elongation | "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:isa_complete, GOC:mah] | 3 | 1.024571e-03 | 12 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 5 | 1.761960e-03 | 12 |
| GO:BP | GO:0000075 | cell cycle checkpoint signaling | "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] | 4 | 2.280535e-03 | 12 |
| GO:BP | GO:1902975 | mitotic DNA replication initiation | "Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] | 2 | 3.107693e-03 | 12 |
| GO:BP | GO:1902315 | nuclear cell cycle DNA replication initiation | "Any DNA replication initiation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] | 2 | 3.107693e-03 | 12 |
| GO:BP | GO:1902292 | cell cycle DNA replication initiation | "Any DNA replication initiation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] | 2 | 3.107693e-03 | 12 |
| GO:BP | GO:1901988 | negative regulation of cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 7.301983e-03 | 12 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 5 | 1.101821e-02 | 12 |
| GO:BP | GO:0010948 | negative regulation of cell cycle process | "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 4 | 1.336440e-02 | 12 |
| GO:BP | GO:0033314 | mitotic DNA replication checkpoint signaling | "A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle] | 2 | 1.706307e-02 | 12 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 5 | 2.258492e-02 | 12 |
| GO:BP | GO:2000105 | positive regulation of DNA-templated DNA replication | "Any process that activates or increases the frequency, rate or extent of DNA-templated DNA replication." [GOC:mah] | 2 | 2.820746e-02 | 12 |
| GO:BP | GO:0033262 | regulation of nuclear cell cycle DNA replication | "Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] | 2 | 2.820746e-02 | 12 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 3.798092e-02 | 12 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 11 | 3.588944e-18 | 12 |
| KEGG | KEGG:03030 | DNA replication | DNA replication | 4 | 5.165393e-06 | 12 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0071162 | CMG complex | "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417] | 5 | 5.162015e-13 | 12 |
| GO:CC | GO:0031261 | DNA replication preinitiation complex | "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184] | 5 | 1.437340e-12 | 12 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 7 | 4.737469e-10 | 12 |
| GO:CC | GO:0042555 | MCM complex | "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] | 4 | 1.165973e-09 | 12 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 6 | 9.330026e-09 | 12 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 7 | 2.125572e-08 | 12 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 11 | 1.399514e-06 | 12 |
| GO:CC | GO:0032993 | protein-DNA complex | "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] | 5 | 7.035112e-06 | 12 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 11 | 2.558547e-05 | 12 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 8 | 6.054443e-05 | 12 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 11 | 2.057724e-04 | 12 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 11 | 2.057724e-04 | 12 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 11 | 2.057724e-04 | 12 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 8 | 5.716907e-04 | 12 |
| GO:CC | GO:0000808 | origin recognition complex | "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] | 2 | 6.740205e-04 | 12 |
| GO:CC | GO:0005664 | nuclear origin of replication recognition complex | "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] | 2 | 6.740205e-04 | 12 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 10 | 5.238406e-03 | 12 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 10 | 5.245975e-03 | 12 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 11 | 1.855441e-02 | 12 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 4 | 3.748603e-02 | 12 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 5 | 4.061453e-02 | 12 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0017116 | single-stranded DNA helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl] | 4 | 8.273667e-08 | 12 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 5 | 6.540830e-07 | 12 |
| GO:MF | GO:0003678 | DNA helicase activity | "Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl] | 4 | 4.210275e-06 | 12 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 6 | 5.699174e-06 | 12 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 6 | 6.878883e-05 | 12 |
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 4 | 8.523319e-05 | 12 |
| GO:MF | GO:0004386 | helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] | 4 | 2.306706e-04 | 12 |
| GO:MF | GO:0120545 | nucleic acid conformation isomerase activity | "Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-] | 4 | 2.942572e-04 | 12 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 8 | 1.411893e-03 | 12 |
| GO:MF | GO:0140097 | catalytic activity, acting on DNA | "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] | 4 | 1.627531e-03 | 12 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 4 | 2.504031e-03 | 12 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 6 | 3.058652e-03 | 12 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 6 | 4.046037e-03 | 12 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 6 | 4.064460e-03 | 12 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 6 | 4.064460e-03 | 12 |
| GO:MF | GO:0003688 | DNA replication origin binding | "Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators] | 2 | 4.847619e-03 | 12 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 6 | 1.156205e-02 | 12 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 6 | 1.349758e-02 | 12 |
| GO:MF | GO:0016853 | isomerase activity | "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] | 4 | 1.422868e-02 | 12 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 6 | 1.872649e-02 | 12 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 9 | 4.534438e-02 | 12 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011267 | Microtia, third degree | Presence of some auricular structures, but none of these structures conform to recognized ear components. | 4 | 4.514662e-07 | 12 |
| HP | HP:0009939 | Mandibular aplasia | Absence of the mandible. | 4 | 9.772511e-07 | 12 |
| HP | HP:0009892 | Anotia | Complete absence of any auricular structures. | 4 | 1.367504e-06 | 12 |
| HP | HP:0100783 | Breast aplasia | Failure to develop and congenital absence of the breast. | 4 | 3.246790e-06 | 12 |
| HP | HP:0006660 | Aplastic clavicle | Absence of the clavicles as a developmental defect. | 4 | 5.282621e-06 | 12 |
| HP | HP:0006443 | Patellar aplasia | Absence of the patella. | 4 | 8.149260e-06 | 12 |
| HP | HP:0000039 | Epispadias | Epispadias is a urogenital malformation characterized by the failure of the urethral tube to tubularize on the dorsal aspect. Unlike in hypospadias, where the meatus is on the ventral aspect, children with epispadias have a wide-open urethral plate on the dorsum. It is commonly seen as a component in the spectrum of bladder exstrophy-epispadias-complex. Isolated epispadias constitutes less than 10 percent of the total cases of epispadias. | 4 | 3.221721e-05 | 12 |
| HP | HP:0040255 | Aplasia/Hypoplasia of the clitoris | Aplasia/Hypoplasia of the clitoris | 4 | 4.264042e-05 | 12 |
| HP | HP:0000060 | Clitoral hypoplasia | Developmental hypoplasia of the clitoris. | 4 | 4.264042e-05 | 12 |
| HP | HP:0000064 | Hypoplastic labia minora | Hypoplastic labia minora | 4 | 4.870878e-05 | 12 |
| HP | HP:0006498 | Aplasia/Hypoplasia of the patella | Absence or underdevelopment of the patella. | 4 | 4.870878e-05 | 12 |
| HP | HP:0000059 | Hypoplastic labia majora | Undergrowth of the outer labia. | 4 | 9.969982e-05 | 12 |
| HP | HP:0012880 | Abnormal labia minora morphology | An anomaly of the labia minora, the folds of skin between the outer labia. | 4 | 9.969982e-05 | 12 |
| HP | HP:0012881 | Abnormal labia majora morphology | An anomaly of the outer labia. | 4 | 2.195725e-04 | 12 |
| HP | HP:0003100 | Slender long bone | Reduced diameter of a long bone. | 4 | 2.615668e-04 | 12 |
| HP | HP:0006710 | Aplasia/Hypoplasia of the clavicles | Absence or underdevelopment of the clavicles (collar bones). | 4 | 3.926980e-04 | 12 |
| HP | HP:0000413 | Atresia of the external auditory canal | Absence or failure to form of the external auditory canal. | 4 | 5.676209e-04 | 12 |
| HP | HP:0000066 | Labial hypoplasia | Labial hypoplasia | 4 | 7.449058e-04 | 12 |
| HP | HP:0003561 | Birth length less than 3rd percentile | Birth length less than 3rd percentile | 3 | 7.870926e-04 | 12 |
| HP | HP:0012815 | Hypoplastic female external genitalia | Underdevelopment of part or all of the female external reproductive organs (which include the mons pubis, labia majora, labia minora, Bartholin glands, and clitoris). | 4 | 9.605627e-04 | 12 |
| HP | HP:0008665 | Clitoral hypertrophy | Hypertrophy of the clitoris. | 4 | 1.150543e-03 | 12 |
| HP | HP:0040253 | Increased size of the clitoris | Increased size of the clitoris | 4 | 1.150543e-03 | 12 |
| HP | HP:0040252 | Abnormal size of the clitoris | Abnormal size of the clitoris | 4 | 1.150543e-03 | 12 |
| HP | HP:0010311 | Aplasia/Hypoplasia of the breasts | Absence or underdevelopment of the breasts. | 4 | 1.367231e-03 | 12 |
| HP | HP:0000176 | Submucous cleft hard palate | Hard-palate submucous clefts are characterized by bony defects in the midline of the bony palate that are covered by the mucous membrane of the roof of the mouth. It may be possible to detect a submucous cleft hard palate upon palpation as a notch in the bony palate. | 4 | 1.445800e-03 | 12 |
| HP | HP:0410005 | Cleft hard palate | Cleft hard palate | 4 | 1.527688e-03 | 12 |
| HP | HP:0003042 | Elbow dislocation | Dislocation of the distal humerus out of the elbow joint, where the radius, ulna, and humerus meet. | 4 | 2.093853e-03 | 12 |
| HP | HP:0100737 | Abnormal hard palate morphology | Abnormal hard palate morphology | 4 | 2.549583e-03 | 12 |
| HP | HP:0000058 | Abnormal labia morphology | An anomaly of the labia, the externally visible portions of the vulva. | 4 | 2.674209e-03 | 12 |
| HP | HP:5201016 | Submucous cleft palate | A cleft of the muscular portion of the palate that is covered by mucous membrane. | 4 | 2.674209e-03 | 12 |
| HP | HP:0030310 | Upper extremity joint dislocation | Displacement or malalignment of one or more joints in the upper extremity (arm). | 4 | 3.366667e-03 | 12 |
| HP | HP:0000056 | Abnormal clitoris morphology | Any structural abnormality of the clitoris. | 4 | 4.184541e-03 | 12 |
| HP | HP:0000372 | Abnormal auditory canal morphology | Any structural abnormality of the external acoustic tube (also known as the auditory canal). | 4 | 4.184541e-03 | 12 |
| HP | HP:0002878 | Respiratory failure | A severe form of respiratory insufficiency characterized by inadequate gas exchange such that the levels of oxygen or carbon dioxide cannot be maintained within normal limits. | 5 | 6.698062e-03 | 12 |
| HP | HP:0003510 | Severe short stature | A severe degree of short stature, more than -4 SD from the mean corrected for age and sex. | 4 | 7.000360e-03 | 12 |
| HP | HP:0003045 | Abnormal patella morphology | Abnormality of the patella (knee cap). | 4 | 7.263552e-03 | 12 |
| HP | HP:0000889 | Abnormal clavicle morphology | Any abnormality of the clavicles (collar bones). | 4 | 9.317251e-03 | 12 |
| HP | HP:0000327 | Hypoplasia of the maxilla | Abnormally small dimension of the Maxilla. Usually creating a malocclusion or malalignment between the upper and lower teeth or resulting in a deficient amount of projection of the base of the nose and lower midface region. | 4 | 1.468148e-02 | 12 |
| HP | HP:0003508 | Proportionate short stature | A kind of short stature in which different regions of the body are shortened to a comparable extent. | 4 | 2.733456e-02 | 12 |
| HP | HP:0000326 | Abnormal maxilla morphology | An abnormality of the Maxilla (upper jaw bone). | 4 | 2.805481e-02 | 12 |
| HP | HP:0002705 | High, narrow palate | The presence of a high and narrow palate. | 4 | 2.953736e-02 | 12 |
| HP | HP:0000055 | Abnormal female external genitalia morphology | Any structural abnormality of the female external genitalia. | 4 | 3.107714e-02 | 12 |
| HP | HP:0000193 | Bifid uvula | Uvula separated into two parts most easily seen at the tip. | 4 | 4.159706e-02 | 12 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00516_1 | Factor: E2F-1; motif: TTTSGCGCGMNR; match class: 1 | Factor: E2F-1; motif: TTTSGCGCGMNR; match class: 1 | 10 | 0.000003 | 12 |
| TF | TF:M00431_1 | Factor: E2F-1; motif: TTTSGCGS; match class: 1 | Factor: E2F-1; motif: TTTSGCGS; match class: 1 | 10 | 0.000006 | 12 |
| TF | TF:M00919_1 | Factor: E2F; motif: NCSCGCSAAAN; match class: 1 | Factor: E2F; motif: NCSCGCSAAAN; match class: 1 | 8 | 0.000283 | 12 |
| TF | TF:M00939_1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | 8 | 0.000582 | 12 |
| TF | TF:M00427_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 10 | 0.001153 | 12 |
| TF | TF:M00739_1 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 | 7 | 0.001281 | 12 |
| TF | TF:M00050_1 | Factor: E2F; motif: TTTSGCGC; match class: 1 | Factor: E2F; motif: TTTSGCGC; match class: 1 | 8 | 0.001387 | 12 |
| TF | TF:M00918_1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | 7 | 0.001733 | 12 |
| TF | TF:M00738_1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | 10 | 0.001764 | 12 |
| TF | TF:M00920_1 | Factor: E2F; motif: NKCGCGCSAAAN; match class: 1 | Factor: E2F; motif: NKCGCGCSAAAN; match class: 1 | 7 | 0.002243 | 12 |
| TF | TF:M00426_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 11 | 0.002540 | 12 |
| TF | TF:M09893_1 | Factor: E2F-3; motif: NNGGCGGGAAA; match class: 1 | Factor: E2F-3; motif: NNGGCGGGAAA; match class: 1 | 7 | 0.002765 | 12 |
| TF | TF:M00740_1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | 10 | 0.006817 | 12 |
| TF | TF:M11537 | Factor: E2F-8; motif: NNTTCCCGCCAAAW | Factor: E2F-8; motif: NNTTCCCGCCAAAW | 5 | 0.008581 | 12 |
| TF | TF:M08875_1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | 7 | 0.015721 | 12 |
| TF | TF:M00431 | Factor: E2F-1; motif: TTTSGCGS | Factor: E2F-1; motif: TTTSGCGS | 11 | 0.029226 | 12 |
| TF | TF:M00737_1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | 8 | 0.042743 | 12 |
| TF | TF:M00918 | Factor: E2F; motif: TTTSGCGSG | Factor: E2F; motif: TTTSGCGSG | 10 | 0.046125 | 12 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2204 | MCM8-ORC2-CDC6 complex | MCM8-ORC2-CDC6 complex | 2 | 0.001265 | 12 |
| CORUM | CORUM:2210 | BRCA1-IRIS-pre-replication complex | BRCA1-IRIS-pre-replication complex | 2 | 0.002527 | 12 |
| CORUM | CORUM:1038 | ORC 1-5 complex (origin recognition 1-5 complex) | ORC 1-5 complex (origin recognition 1-5 complex) | 2 | 0.004207 | 12 |
| CORUM | CORUM:1033 | ORC complex (origin recognition complex) | ORC complex (origin recognition complex) | 2 | 0.006304 | 12 |
| CORUM | CORUM:1031 | ORC complex (origin recognition complex) | ORC complex (origin recognition complex) | 2 | 0.006304 | 12 |
| CORUM | CORUM:389 | ORC complex (origin recognition complex) | ORC complex (origin recognition complex) | 2 | 0.006304 | 12 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 6 | 0.002183 | 12 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0030433 | Appendix; germinal center cells[High] | Appendix; germinal center cells[High] | 3 | 0.005062 | 12 |
| HPA | HPA:0570781 | Testis; preleptotene spermatocytes[≥Low] | Testis; preleptotene spermatocytes[≥Low] | 7 | 0.013491 | 12 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 4 | 0.018844 | 12 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 4 | 0.021207 | 12 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 4 | 0.027554 | 12 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 4 | 0.031200 | 12 |
Community 13
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070533 | BRCA1-C complex | "A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint." [GOC:mah, PMID:15485915, PMID:16391231] | 3 | 6.095088e-08 | 13 |
| GO:CC | GO:0030870 | Mre11 complex | "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145] | 2 | 2.024423e-04 | 13 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 6 | 5.501712e-04 | 13 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 4 | 5.764790e-04 | 13 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 7 | 1.517037e-03 | 13 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 3 | 2.440058e-03 | 13 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 7 | 9.633080e-03 | 13 |
| GO:CC | GO:0097431 | mitotic spindle pole | "Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:vw] | 2 | 9.951081e-03 | 13 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 7 | 3.531024e-02 | 13 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 7 | 3.534734e-02 | 13 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 7 | 3.628566e-02 | 13 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 7 | 3.628566e-02 | 13 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 7 | 3.628566e-02 | 13 |
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 2 | 3.706464e-02 | 13 |
| GO:CC | GO:0000794 | condensed nuclear chromosome | "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh] | 2 | 4.431059e-02 | 13 |
| GO:CC | GO:1905720 | cytoplasmic microtubule bundle | "Any microtubule bundle that is part of a cytoplasm." [GO_REF:0000064, GOC:TermGenie, PMID:11007487, PMID:26124291] | 1 | 4.984879e-02 | 13 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4016 | DNA IR damage and cellular response via ATR | DNA IR damage and cellular response via ATR | 5 | 1.469983e-07 | 13 |
| WP | WP:WP5118 | SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome | SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome | 3 | 6.109363e-06 | 13 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 4 | 1.441466e-05 | 13 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 4 | 1.812842e-05 | 13 |
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 4 | 1.305862e-04 | 13 |
| WP | WP:WP2516 | ATM signaling | ATM signaling | 3 | 2.851379e-04 | 13 |
| WP | WP:WP1971 | Integrated cancer pathway | Integrated cancer pathway | 3 | 4.848506e-04 | 13 |
| WP | WP:WP3878 | ATM signaling in development and disease | ATM signaling in development and disease | 3 | 5.930039e-04 | 13 |
| WP | WP:WP3959 | DNA IR double strand breaks and cellular response via ATM | DNA IR double strand breaks and cellular response via ATM | 3 | 9.568112e-04 | 13 |
| WP | WP:WP2942 | DDX1 as a regulatory component of the Drosha microprocessor | DDX1 as a regulatory component of the Drosha microprocessor | 2 | 1.361864e-03 | 13 |
| WP | WP:WP186 | Homologous recombination | Homologous recombination | 2 | 5.046797e-03 | 13 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 3 | 8.370026e-03 | 13 |
| WP | WP:WP531 | DNA mismatch repair | DNA mismatch repair | 2 | 1.630745e-02 | 13 |
| WP | WP:WP1984 | Integrated breast cancer pathway | Integrated breast cancer pathway | 3 | 2.023759e-02 | 13 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:433 | BASC complex (BRCA1-associated genome surveillance complex) | BASC complex (BRCA1-associated genome surveillance complex) | 4 | 3.634605e-07 | 13 |
| CORUM | CORUM:2815 | BRCA1-BARD1-BACH1-DNA damage complex II | BRCA1-BARD1-BACH1-DNA damage complex II | 3 | 3.478872e-05 | 13 |
| CORUM | CORUM:73 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:331 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:972 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:173 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:618 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:71 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:2767 | RAD50-MRE11-NBN-p200-p350 complex | RAD50-MRE11-NBN-p200-p350 complex | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:1081 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 2 | 1.264583e-03 | 13 |
| CORUM | CORUM:627 | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) | 2 | 2.526672e-03 | 13 |
| CORUM | CORUM:202 | BRCA1-RAD50-MRE11-NBS1 complex | BRCA1-RAD50-MRE11-NBS1 complex | 2 | 2.526672e-03 | 13 |
| CORUM | CORUM:964 | BRCA1-RAD50-MRE11-NBS1 complex | BRCA1-RAD50-MRE11-NBS1 complex | 2 | 2.526672e-03 | 13 |
| CORUM | CORUM:2218 | MDC1-MRE11-RAD50-NBS1 complex | MDC1-MRE11-RAD50-NBS1 complex | 2 | 2.526672e-03 | 13 |
| CORUM | CORUM:619 | MRE11A-RAD50-NBN-TRF2 complex | MRE11A-RAD50-NBN-TRF2 complex | 2 | 2.526672e-03 | 13 |
| CORUM | CORUM:1189 | DNA double-strand break end-joining complex | DNA double-strand break end-joining complex | 2 | 4.206968e-03 | 13 |
| CORUM | CORUM:5197 | PTIP-DNA damage response complex | PTIP-DNA damage response complex | 2 | 6.304228e-03 | 13 |
| CORUM | CORUM:2217 | MDC1-MRN-ATM-FANCD2 complex | MDC1-MRN-ATM-FANCD2 complex | 2 | 6.304228e-03 | 13 |
| CORUM | CORUM:434 | BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) | BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) | 2 | 1.174469e-02 | 13 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0110025 | DNA strand resection involved in replication fork processing | "The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing." [GOC:mah, PMID:28475874] | 3 | 0.000003 | 13 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 6 | 0.000003 | 13 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 6 | 0.000004 | 13 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 6 | 0.000013 | 13 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 6 | 0.000039 | 13 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 6 | 0.000043 | 13 |
| GO:BP | GO:0007093 | mitotic cell cycle checkpoint signaling | "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] | 4 | 0.000058 | 13 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 6 | 0.000079 | 13 |
| GO:BP | GO:0006261 | DNA-templated DNA replication | "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] | 4 | 0.000111 | 13 |
| GO:BP | GO:0000075 | cell cycle checkpoint signaling | "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] | 4 | 0.000199 | 13 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 6 | 0.000334 | 13 |
| GO:BP | GO:0045930 | negative regulation of mitotic cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 0.000436 | 13 |
| GO:BP | GO:0031297 | replication fork processing | "The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542] | 3 | 0.000467 | 13 |
| GO:BP | GO:0031860 | telomeric 3' overhang formation | "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans." [PMID:16096639] | 2 | 0.000570 | 13 |
| GO:BP | GO:0044818 | mitotic G2/M transition checkpoint | "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 0.000588 | 13 |
| GO:BP | GO:1901988 | negative regulation of cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 0.000643 | 13 |
| GO:BP | GO:0045005 | DNA-templated DNA replication maintenance of fidelity | "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw] | 3 | 0.000729 | 13 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 5 | 0.000921 | 13 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 4 | 0.001089 | 13 |
| GO:BP | GO:0035825 | homologous recombination | "A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules." [GOC:mah, PMID:11139492, PMID:17304215] | 3 | 0.001122 | 13 |
| GO:BP | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 0.001173 | 13 |
| GO:BP | GO:0010948 | negative regulation of cell cycle process | "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 4 | 0.001184 | 13 |
| GO:BP | GO:1902750 | negative regulation of cell cycle G2/M phase transition | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 3 | 0.001279 | 13 |
| GO:BP | GO:0051321 | meiotic cell cycle | "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] | 4 | 0.001321 | 13 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 6 | 0.001585 | 13 |
| GO:BP | GO:0006310 | DNA recombination | "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] | 4 | 0.002454 | 13 |
| GO:BP | GO:1904354 | negative regulation of telomere capping | "Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 2 | 0.002658 | 13 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 6 | 0.002795 | 13 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 0.003412 | 13 |
| GO:BP | GO:0062176 | R-loop processing | "A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability." [PMID:27252122, PMID:28790157, PMID:33986538] | 2 | 0.003416 | 13 |
| GO:BP | GO:0010389 | regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565] | 3 | 0.004174 | 13 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 3 | 0.004174 | 13 |
| GO:BP | GO:0000077 | DNA damage checkpoint signaling | "A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah] | 3 | 0.005348 | 13 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 0.005593 | 13 |
| GO:BP | GO:1902749 | regulation of cell cycle G2/M phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 3 | 0.005933 | 13 |
| GO:BP | GO:0031570 | DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] | 3 | 0.006721 | 13 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 5 | 0.007043 | 13 |
| GO:BP | GO:0019953 | sexual reproduction | "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] | 5 | 0.008230 | 13 |
| GO:BP | GO:1904353 | regulation of telomere capping | "Any process that modulates the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 2 | 0.008629 | 13 |
| GO:BP | GO:0000086 | G2/M transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] | 3 | 0.009706 | 13 |
| GO:BP | GO:0051053 | negative regulation of DNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 3 | 0.009706 | 13 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 0.009802 | 13 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 4 | 0.010448 | 13 |
| GO:BP | GO:0000018 | regulation of DNA recombination | "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732] | 3 | 0.010792 | 13 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 4 | 0.013350 | 13 |
| GO:BP | GO:0044839 | cell cycle G2/M phase transition | "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle] | 3 | 0.013719 | 13 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 3 | 0.015937 | 13 |
| GO:BP | GO:1901991 | negative regulation of mitotic cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 3 | 0.018380 | 13 |
| GO:BP | GO:0042770 | signal transduction in response to DNA damage | "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators] | 3 | 0.018701 | 13 |
| GO:BP | GO:0000729 | DNA double-strand break processing | "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855] | 2 | 0.021877 | 13 |
| GO:BP | GO:0031954 | positive regulation of protein autophosphorylation | "Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] | 2 | 0.021877 | 13 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 3 | 0.025143 | 13 |
| GO:BP | GO:0006312 | mitotic recombination | "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles." [GOC:elh] | 2 | 0.028398 | 13 |
| GO:BP | GO:0016233 | telomere capping | "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055] | 2 | 0.033216 | 13 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 5 | 0.037476 | 13 |
| GO:BP | GO:0022414 | reproductive process | "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] | 5 | 0.047907 | 13 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9675135 | Diseases of DNA repair | Diseases of DNA repair | 4 | 0.000003 | 13 |
| REAC | REAC:R-HSA-5685942 | HDR through Homologous Recombination (HRR) | HDR through Homologous Recombination (HRR) | 4 | 0.000012 | 13 |
| REAC | REAC:R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | Impaired BRCA2 binding to PALB2 | 3 | 0.000073 | 13 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 6 | 0.000083 | 13 |
| REAC | REAC:R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3 | 0.000083 | 13 |
| REAC | REAC:R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3 | 0.000083 | 13 |
| REAC | REAC:R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | 3 | 0.000083 | 13 |
| REAC | REAC:R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | 3 | 0.000083 | 13 |
| REAC | REAC:R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 3 | 0.000106 | 13 |
| REAC | REAC:R-HSA-73894 | DNA Repair | DNA Repair | 5 | 0.000107 | 13 |
| REAC | REAC:R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4 | 0.000165 | 13 |
| REAC | REAC:R-HSA-5693538 | Homology Directed Repair | Homology Directed Repair | 4 | 0.000197 | 13 |
| REAC | REAC:R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | Impaired BRCA2 binding to RAD51 | 3 | 0.000236 | 13 |
| REAC | REAC:R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | Resolution of D-loop Structures through Holliday Junction Intermediates | 3 | 0.000257 | 13 |
| REAC | REAC:R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | HDR through Single Strand Annealing (SSA) | 3 | 0.000280 | 13 |
| REAC | REAC:R-HSA-5693537 | Resolution of D-Loop Structures | Resolution of D-Loop Structures | 3 | 0.000280 | 13 |
| REAC | REAC:R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | Presynaptic phase of homologous DNA pairing and strand exchange | 3 | 0.000355 | 13 |
| REAC | REAC:R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | Diseases of DNA Double-Strand Break Repair | 3 | 0.000383 | 13 |
| REAC | REAC:R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3 | 0.000383 | 13 |
| REAC | REAC:R-HSA-5693532 | DNA Double-Strand Break Repair | DNA Double-Strand Break Repair | 4 | 0.000428 | 13 |
| REAC | REAC:R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | Homologous DNA Pairing and Strand Exchange | 3 | 0.000443 | 13 |
| REAC | REAC:R-HSA-5693548 | Sensing of DNA Double Strand Breaks | Sensing of DNA Double Strand Breaks | 2 | 0.001197 | 13 |
| REAC | REAC:R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | Nonhomologous End-Joining (NHEJ) | 3 | 0.001788 | 13 |
| REAC | REAC:R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | 3 | 0.002604 | 13 |
| REAC | REAC:R-HSA-5693606 | DNA Double Strand Break Response | DNA Double Strand Break Response | 3 | 0.002707 | 13 |
| REAC | REAC:R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Regulation of TP53 Activity through Phosphorylation | 3 | 0.004452 | 13 |
| REAC | REAC:R-HSA-69473 | G2/M DNA damage checkpoint | G2/M DNA damage checkpoint | 3 | 0.004749 | 13 |
| REAC | REAC:R-HSA-5693607 | Processing of DNA double-strand break ends | Processing of DNA double-strand break ends | 3 | 0.005220 | 13 |
| REAC | REAC:R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | HDR through MMEJ (alt-NHEJ) | 2 | 0.005259 | 13 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 4 | 0.008311 | 13 |
| REAC | REAC:R-HSA-1500620 | Meiosis | Meiosis | 3 | 0.008926 | 13 |
| REAC | REAC:R-HSA-1474165 | Reproduction | Reproduction | 3 | 0.020804 | 13 |
| REAC | REAC:R-HSA-5633007 | Regulation of TP53 Activity | Regulation of TP53 Activity | 3 | 0.023310 | 13 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 3 | 0.026475 | 13 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03440 | Homologous recombination | Homologous recombination | 3 | 0.000102 | 13 |
| KEGG | KEGG:03430 | Mismatch repair | Mismatch repair | 2 | 0.005136 | 13 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0030406 | Primary peritoneal carcinoma | A type of cancer that originates in the peritoneum. It is to be distinguished from metastatic cancer of the peritoneum. Peritoneal cancer can occur anywhere in the abdominal space, and affects the surface of organs contained inside the peritoneum. | 3 | 0.000630 | 13 |
| HP | HP:0003002 | Breast carcinoma | The presence of a carcinoma of the breast. | 4 | 0.001292 | 13 |
| HP | HP:0100615 | Ovarian neoplasm | A tumor (abnormal growth of tissue) of the ovary. | 4 | 0.001528 | 13 |
| HP | HP:0002894 | Neoplasm of the pancreas | A tumor (abnormal growth of tissue) of the pancreas. | 4 | 0.002937 | 13 |
| HP | HP:0100013 | Neoplasm of the breast | A tumor (abnormal growth of tissue) of the breast. | 4 | 0.004364 | 13 |
| HP | HP:0011027 | Abnormal fallopian tube morphology | An abnormality of the fallopian tube. | 3 | 0.005024 | 13 |
| HP | HP:0010785 | Gonadal neoplasm | A tumor (abnormal growth of tissue) of a gonad. | 4 | 0.005789 | 13 |
| HP | HP:0012125 | Prostate cancer | A cancer of the prostate. | 3 | 0.009338 | 13 |
| HP | HP:0100787 | Prostate neoplasm | Prostate neoplasm | 3 | 0.009338 | 13 |
| HP | HP:0008775 | Abnormal prostate morphology | An abnormality of the prostate. | 3 | 0.018158 | 13 |
| HP | HP:0010787 | Genital neoplasm | A tumor (abnormal growth of tissue) of the genital system. | 4 | 0.028055 | 13 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 4 | 0.000807 | 13 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 3 | 0.001061 | 13 |
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 3 | 0.001114 | 13 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 6 | 0.003519 | 13 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 4 | 0.004251 | 13 |
| GO:MF | GO:0140097 | catalytic activity, acting on DNA | "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] | 3 | 0.010193 | 13 |
| GO:MF | GO:0043539 | protein serine/threonine kinase activator activity | "Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators] | 2 | 0.034357 | 13 |
| GO:MF | GO:0003684 | damaged DNA binding | "Binding to damaged DNA." [GOC:jl] | 2 | 0.041690 | 13 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 4 | 0.013300 | 13 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 6 | 0.020624 | 13 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 7 | 0.020833 | 13 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 4 | 0.021718 | 13 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 4 | 0.022161 | 13 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 4 | 0.037495 | 13 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 4 | 0.046251 | 13 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 6 | 0.047770 | 13 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 4 | 0.049923 | 13 |
Community 14
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9614085 | FOXO-mediated transcription | FOXO-mediated transcription | 7 | 6.542965e-12 | 14 |
| REAC | REAC:R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | Activation of gene expression by SREBF (SREBP) | 5 | 3.346474e-08 | 14 |
| REAC | REAC:R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5 | 1.452264e-07 | 14 |
| REAC | REAC:R-HSA-9614657 | FOXO-mediated transcription of cell death genes | FOXO-mediated transcription of cell death genes | 4 | 1.710644e-07 | 14 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 9 | 6.754804e-06 | 14 |
| REAC | REAC:R-HSA-1989781 | PPARA activates gene expression | PPARA activates gene expression | 5 | 6.942949e-06 | 14 |
| REAC | REAC:R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | Regulation of lipid metabolism by PPARalpha | 5 | 7.258662e-06 | 14 |
| REAC | REAC:R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | ATF6 (ATF6-alpha) activates chaperone genes | 3 | 1.243750e-05 | 14 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 9 | 1.554386e-05 | 14 |
| REAC | REAC:R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | ATF6 (ATF6-alpha) activates chaperones | 3 | 2.440748e-05 | 14 |
| REAC | REAC:R-HSA-8957322 | Metabolism of steroids | Metabolism of steroids | 5 | 3.083135e-05 | 14 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 9 | 4.268093e-05 | 14 |
| REAC | REAC:R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | NOTCH4 Intracellular Domain Regulates Transcription | 3 | 1.679103e-04 | 14 |
| REAC | REAC:R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | ATF4 activates genes in response to endoplasmic reticulum stress | 3 | 4.293841e-04 | 14 |
| REAC | REAC:R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | SMAD2/3 MH2 Domain Mutants in Cancer | 2 | 6.123364e-04 | 14 |
| REAC | REAC:R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | SMAD4 MH2 Domain Mutants in Cancer | 2 | 6.123364e-04 | 14 |
| REAC | REAC:R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | Loss of Function of SMAD4 in Cancer | 2 | 6.123364e-04 | 14 |
| REAC | REAC:R-HSA-381042 | PERK regulates gene expression | PERK regulates gene expression | 3 | 7.263804e-04 | 14 |
| REAC | REAC:R-HSA-9758941 | Gastrulation | Gastrulation | 4 | 8.684282e-04 | 14 |
| REAC | REAC:R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3 | 1.043639e-03 | 14 |
| REAC | REAC:R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | TGFBR1 KD Mutants in Cancer | 2 | 2.039143e-03 | 14 |
| REAC | REAC:R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 2 | 2.039143e-03 | 14 |
| REAC | REAC:R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3 | 2.845779e-03 | 14 |
| REAC | REAC:R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | Loss of Function of SMAD2/3 in Cancer | 2 | 3.057232e-03 | 14 |
| REAC | REAC:R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | Loss of Function of TGFBR1 in Cancer | 2 | 3.057232e-03 | 14 |
| REAC | REAC:R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | Signaling by TGF-beta Receptor Complex in Cancer | 2 | 4.278050e-03 | 14 |
| REAC | REAC:R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | Regulation of FOXO transcriptional activity by acetylation | 2 | 9.153923e-03 | 14 |
| REAC | REAC:R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | NFE2L2 regulating tumorigenic genes | 2 | 1.118270e-02 | 14 |
| REAC | REAC:R-HSA-9013694 | Signaling by NOTCH4 | Signaling by NOTCH4 | 3 | 1.220543e-02 | 14 |
| REAC | REAC:R-HSA-381119 | Unfolded Protein Response (UPR) | Unfolded Protein Response (UPR) | 3 | 1.787042e-02 | 14 |
| REAC | REAC:R-HSA-170834 | Signaling by TGF-beta Receptor Complex | Signaling by TGF-beta Receptor Complex | 3 | 1.787042e-02 | 14 |
| REAC | REAC:R-HSA-8941856 | RUNX3 regulates NOTCH signaling | RUNX3 regulates NOTCH signaling | 2 | 1.847540e-02 | 14 |
| REAC | REAC:R-HSA-9796292 | Formation of axial mesoderm | Formation of axial mesoderm | 2 | 1.847540e-02 | 14 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 3 | 1.966859e-02 | 14 |
| REAC | REAC:R-HSA-9823730 | Formation of definitive endoderm | Formation of definitive endoderm | 2 | 2.130743e-02 | 14 |
| REAC | REAC:R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2 | 2.130743e-02 | 14 |
| REAC | REAC:R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | 2 | 2.433954e-02 | 14 |
| REAC | REAC:R-HSA-1502540 | Signaling by Activin | Signaling by Activin | 2 | 2.757144e-02 | 14 |
| REAC | REAC:R-HSA-9754189 | Germ layer formation at gastrulation | Germ layer formation at gastrulation | 2 | 2.757144e-02 | 14 |
| REAC | REAC:R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | FOXO-mediated transcription of cell cycle genes | 2 | 2.757144e-02 | 14 |
| REAC | REAC:R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2 | 3.846293e-02 | 14 |
| REAC | REAC:R-HSA-9006936 | Signaling by TGFB family members | Signaling by TGFB family members | 3 | 4.141370e-02 | 14 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 9 | 1.683227e-08 | 14 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 7 | 4.910353e-08 | 14 |
| GO:CC | GO:0016602 | CCAAT-binding factor complex | "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851] | 3 | 7.327479e-08 | 14 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 9 | 4.009376e-07 | 14 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 5 | 5.274649e-06 | 14 |
| GO:CC | GO:0032993 | protein-DNA complex | "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] | 4 | 3.066980e-04 | 14 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 9 | 3.239547e-04 | 14 |
| GO:CC | GO:0071144 | heteromeric SMAD protein complex | "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020] | 2 | 5.674347e-04 | 14 |
| GO:CC | GO:0071141 | SMAD protein complex | "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020] | 2 | 7.293832e-04 | 14 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 9 | 3.269697e-03 | 14 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 9 | 1.634703e-02 | 14 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 9 | 1.636820e-02 | 14 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 9 | 1.690546e-02 | 14 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 9 | 1.690546e-02 | 14 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 9 | 1.690546e-02 | 14 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 7 | 9.215998e-08 | 14 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 7 | 3.843143e-07 | 14 |
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 9 | 1.178219e-06 | 14 |
| GO:MF | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] | 8 | 3.413265e-06 | 14 |
| GO:MF | GO:0000976 | transcription cis-regulatory region binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] | 8 | 5.847432e-06 | 14 |
| GO:MF | GO:0001067 | transcription regulatory region nucleic acid binding | "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] | 8 | 5.878531e-06 | 14 |
| GO:MF | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] | 6 | 5.946019e-06 | 14 |
| GO:MF | GO:0001216 | DNA-binding transcription activator activity | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018] | 6 | 6.481915e-06 | 14 |
| GO:MF | GO:1990837 | sequence-specific double-stranded DNA binding | "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] | 8 | 8.070020e-06 | 14 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 9 | 1.226668e-05 | 14 |
| GO:MF | GO:0003690 | double-stranded DNA binding | "Binding to double-stranded DNA." [GOC:elh, GOC:vw] | 8 | 1.302140e-05 | 14 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 8 | 1.385312e-05 | 14 |
| GO:MF | GO:0001221 | transcription coregulator binding | "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] | 4 | 4.045224e-05 | 14 |
| GO:MF | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018] | 7 | 4.236317e-05 | 14 |
| GO:MF | GO:0000987 | cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018] | 7 | 4.834046e-05 | 14 |
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 5 | 6.178903e-05 | 14 |
| GO:MF | GO:0043425 | bHLH transcription factor binding | "Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] | 3 | 7.710513e-05 | 14 |
| GO:MF | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018] | 7 | 1.099886e-04 | 14 |
| GO:MF | GO:0003700 | DNA-binding transcription factor activity | "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] | 7 | 1.686941e-04 | 14 |
| GO:MF | GO:0070410 | co-SMAD binding | "Binding to a common mediator SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 2 | 2.609008e-03 | 14 |
| GO:MF | GO:0010484 | histone H3 acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [PMID:19056256] | 2 | 4.147414e-03 | 14 |
| GO:MF | GO:0070411 | I-SMAD binding | "Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 2 | 4.738653e-03 | 14 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 9 | 9.835640e-03 | 14 |
| GO:MF | GO:0035035 | histone acetyltransferase binding | "Binding to an histone acetyltransferase." [GOC:bf] | 2 | 1.087595e-02 | 14 |
| GO:MF | GO:0070412 | R-SMAD binding | "Binding to a receptor-regulated SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] | 2 | 1.280008e-02 | 14 |
| GO:MF | GO:0005160 | transforming growth factor beta receptor binding | "Binding to a transforming growth factor beta receptor." [GOC:ai] | 2 | 1.280008e-02 | 14 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 4 | 3.143872e-02 | 14 |
| GO:MF | GO:0004402 | histone acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48, PMID:19056256] | 2 | 3.879627e-02 | 14 |
| GO:MF | GO:0001223 | transcription coactivator binding | "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] | 2 | 4.234007e-02 | 14 |
| GO:MF | GO:0061733 | protein-lysine-acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide. The acetyl group is transferred to the nitrogen atom at position 6 of the lysine residue in the protein." [GOC:dph, RHEA:45948] | 2 | 4.603671e-02 | 14 |
| GO:MF | GO:0001222 | transcription corepressor binding | "Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc] | 2 | 4.603671e-02 | 14 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 9 | 1.037606e-07 | 14 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 9 | 1.537299e-06 | 14 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 9 | 1.553577e-06 | 14 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 9 | 3.092190e-06 | 14 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 9 | 7.821874e-06 | 14 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 9 | 6.401693e-05 | 14 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 9 | 6.740512e-05 | 14 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 9 | 9.528419e-05 | 14 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 9 | 1.000978e-04 | 14 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 9 | 5.537979e-04 | 14 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 9 | 7.623445e-04 | 14 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 9 | 8.007322e-04 | 14 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 9 | 1.087891e-03 | 14 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 9 | 1.224900e-03 | 14 |
| GO:BP | GO:0018076 | N-terminal peptidyl-lysine acetylation | "The acetylation of the N-terminal lysine of proteins." [GOC:ai] | 2 | 1.419653e-03 | 14 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 9 | 1.523418e-03 | 14 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 9 | 3.055617e-03 | 14 |
| GO:BP | GO:0048617 | embryonic foregut morphogenesis | "The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] | 2 | 8.507121e-03 | 14 |
| GO:BP | GO:0048511 | rhythmic process | "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] | 4 | 9.895877e-03 | 14 |
| GO:BP | GO:0007440 | foregut morphogenesis | "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid] | 2 | 1.063120e-02 | 14 |
| GO:BP | GO:0048340 | paraxial mesoderm morphogenesis | "The process in which the anatomical structures of the paraxial mesoderm are generated and organized." [GOC:go_curators] | 2 | 1.299040e-02 | 14 |
| GO:BP | GO:0006474 | N-terminal protein amino acid acetylation | "The acetylation of the N-terminal amino acid of proteins." [GOC:ai] | 2 | 2.477469e-02 | 14 |
| GO:BP | GO:0060039 | pericardium development | "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438] | 2 | 4.030643e-02 | 14 |
| GO:BP | GO:0038092 | nodal signaling pathway | "The series of molecular signals initiated by nodal protein binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:vk, PMID:17287255] | 2 | 4.030643e-02 | 14 |
| GO:BP | GO:0031053 | primary miRNA processing | "A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354, PMID:25799998] | 2 | 4.030643e-02 | 14 |
| GO:BP | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah] | 3 | 4.064536e-02 | 14 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 9 | 4.256782e-02 | 14 |
| GO:BP | GO:1903844 | regulation of cellular response to transforming growth factor beta stimulus | "Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] | 3 | 4.326290e-02 | 14 |
| GO:BP | GO:0048339 | paraxial mesoderm development | "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh] | 2 | 4.477356e-02 | 14 |
| GO:BP | GO:0018394 | peptidyl-lysine acetylation | "The acetylation of peptidyl-lysine." [GOC:mah] | 2 | 4.947401e-02 | 14 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2829 | RSmad complex | RSmad complex | 3 | 0.000010 | 14 |
| CORUM | CORUM:2641 | CREBBP-KAT2B-MYOD1 complex | CREBBP-KAT2B-MYOD1 complex | 2 | 0.000074 | 14 |
| CORUM | CORUM:3749 | CREBBP-SMAD2 hexameric complex | CREBBP-SMAD2 hexameric complex | 2 | 0.000074 | 14 |
| CORUM | CORUM:3750 | CREBBP-SMAD3 hexameric complex | CREBBP-SMAD3 hexameric complex | 2 | 0.000074 | 14 |
| CORUM | CORUM:2834 | SMAD4-SMAD2-SMAD3 complex | SMAD4-SMAD2-SMAD3 complex | 2 | 0.000221 | 14 |
| CORUM | CORUM:2706 | SMAD3-SMAD4-SP1 complex | SMAD3-SMAD4-SP1 complex | 2 | 0.000221 | 14 |
| CORUM | CORUM:3753 | CREBBP-SMAD2-SMAD4 pentameric complex | CREBBP-SMAD2-SMAD4 pentameric complex | 2 | 0.000221 | 14 |
| CORUM | CORUM:3754 | CREBBP-SMAD3-SMAD4 pentameric complex | CREBBP-SMAD3-SMAD4 pentameric complex | 2 | 0.000221 | 14 |
| CORUM | CORUM:2830 | TIF1gamma-SMAD2-SMAD3 complex | TIF1gamma-SMAD2-SMAD3 complex | 2 | 0.000221 | 14 |
| CORUM | CORUM:3062 | RNA polymerase II complex, (CBP, RPBI, PCAF, BAF47), chromatin structure modifying | RNA polymerase II complex, (CBP, RPBI, PCAF, BAF47), chromatin structure modifying | 2 | 0.000221 | 14 |
| CORUM | CORUM:1827 | PML-SMAD2/3-SARA complex | PML-SMAD2/3-SARA complex | 2 | 0.000441 | 14 |
| CORUM | CORUM:4 | Multisubunit ACTR coactivator complex | Multisubunit ACTR coactivator complex | 2 | 0.000441 | 14 |
| CORUM | CORUM:3061 | RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying | RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying | 2 | 0.000441 | 14 |
| CORUM | CORUM:3137 | MASH1 promoter-coactivator complex | MASH1 promoter-coactivator complex | 2 | 0.000735 | 14 |
| CORUM | CORUM:3142 | CAMK2-delta-MASH1 promoter-coactivator complex | CAMK2-delta-MASH1 promoter-coactivator complex | 2 | 0.001101 | 14 |
| CORUM | CORUM:3066 | RNA polymerase II complex, chromatin structure modifying | RNA polymerase II complex, chromatin structure modifying | 2 | 0.004022 | 14 |
| CORUM | CORUM:3198 | SKI-SMAD2 complex | SKI-SMAD2 complex | 1 | 0.049819 | 14 |
| CORUM | CORUM:3199 | SKI-SMAD3 complex | SKI-SMAD3 complex | 1 | 0.049819 | 14 |
| CORUM | CORUM:5198 | CBP-RARA-RXRA-DNA complex, ligand stimulated | CBP-RARA-RXRA-DNA complex, ligand stimulated | 1 | 0.049819 | 14 |
| CORUM | CORUM:4478 | CBF-DNA complex | CBF-DNA complex | 1 | 0.049819 | 14 |
| CORUM | CORUM:3729 | SKI-SMAD2 complex | SKI-SMAD2 complex | 1 | 0.049819 | 14 |
| CORUM | CORUM:3733 | SKI-SMAD3 complex | SKI-SMAD3 complex | 1 | 0.049819 | 14 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4879 | Overlap between signal transduction pathways contributing to LMNA laminopathies | Overlap between signal transduction pathways contributing to LMNA laminopathies | 4 | 0.000015 | 14 |
| WP | WP:WP138 | Androgen receptor signaling | Androgen receptor signaling | 4 | 0.000074 | 14 |
| WP | WP:WP706 | Sudden infant death syndrome SIDS susceptibility pathways | Sudden infant death syndrome SIDS susceptibility pathways | 4 | 0.000911 | 14 |
| WP | WP:WP560 | TGF beta receptor signaling | TGF beta receptor signaling | 3 | 0.001688 | 14 |
| WP | WP:WP4816 | TGF beta receptor signaling in skeletal dysplasias | TGF beta receptor signaling in skeletal dysplasias | 3 | 0.002088 | 14 |
| WP | WP:WP2324 | AGE RAGE pathway | AGE RAGE pathway | 3 | 0.002931 | 14 |
| WP | WP:WP5158 | Urotensin II mediated signaling | Urotensin II mediated signaling | 3 | 0.003351 | 14 |
| WP | WP:WP5382 | TGFB Smad signaling | TGFB Smad signaling | 2 | 0.006304 | 14 |
| WP | WP:WP3874 | Canonical and non canonical TGF B signaling | Canonical and non canonical TGF B signaling | 2 | 0.012961 | 14 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 3 | 0.014694 | 14 |
| WP | WP:WP3859 | TGF beta signaling in thyroid cells for epithelial mesenchymal transition | TGF beta signaling in thyroid cells for epithelial mesenchymal transition | 2 | 0.016281 | 14 |
| WP | WP:WP4942 | 15q13 3 copy number variation syndrome | 15q13 3 copy number variation syndrome | 2 | 0.016281 | 14 |
| WP | WP:WP5103 | Progeria associated lipodystrophy | Progeria associated lipodystrophy | 2 | 0.021964 | 14 |
| WP | WP:WP3668 | Hypothesized pathways in pathogenesis of cardiovascular disease | Hypothesized pathways in pathogenesis of cardiovascular disease | 2 | 0.028485 | 14 |
| WP | WP:WP4666 | Hepatitis B infection | Hepatitis B infection | 3 | 0.035408 | 14 |
| WP | WP:WP5036 | Angiotensin II receptor type 1 pathway | Angiotensin II receptor type 1 pathway | 2 | 0.035842 | 14 |
| WP | WP:WP2870 | Extracellular vesicle mediated signaling in recipient cells | Extracellular vesicle mediated signaling in recipient cells | 2 | 0.038480 | 14 |
| WP | WP:WP3414 | Initiation of transcription and translation elongation at the HIV 1 LTR | Initiation of transcription and translation elongation at the HIV 1 LTR | 2 | 0.046945 | 14 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 5 | 0.000149 | 14 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | TGF-beta signaling pathway | 4 | 0.000291 | 14 |
| KEGG | KEGG:05152 | Tuberculosis | Tuberculosis | 4 | 0.002045 | 14 |
| KEGG | KEGG:04612 | Antigen processing and presentation | Antigen processing and presentation | 3 | 0.003639 | 14 |
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 3 | 0.041603 | 14 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 3 | 0.041603 | 14 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0100323 | Juvenile aseptic necrosis | Juvenile aseptic necrosis comprises a group of orthopedic diseases characterized by interruption of the blood supply of a bone, followed by localized bony necrosis most often of the epiphyses of bones of children or teenagers. | 3 | 0.005475 | 14 |
| HP | HP:0008419 | Intervertebral disk degeneration | The presence of degenerative changes of intervertebral disk. | 2 | 0.011381 | 14 |
| HP | HP:0010886 | Osteochondritis dissecans | A joint disorder caused by blood deprivation in the subchondral bone causing the subchondral bone to die in a process called avascular necrosis. The bone is then reabsorbed by the body, leaving the articular cartilage it supported prone to damage. The result is fragmentation (dissection) of both cartilage and bone, and the free movement of these osteochondral fragments within the joint space, causing pain and further damage. | 2 | 0.015928 | 14 |
| HP | HP:0006687 | Aortic tortuosity | Abnormal tortuous (i.e., twisted) form of the aorta. | 2 | 0.021228 | 14 |
| HP | HP:0100718 | Uterine rupture | Uterine rupture | 2 | 0.027283 | 14 |
| HP | HP:0000987 | Atypical scarring of skin | Atypically scarred skin . | 3 | 0.029675 | 14 |
| HP | HP:0040188 | Osteochondrosis | Abnormal growth ossification centers in children. Initially a degeneration/ necrosis followed by regeneration or recalcification. | 2 | 0.049960 | 14 |
| HP | HP:0005294 | Arterial dissection | A separation (dissection) of the layers of an artery. | 2 | 0.049960 | 14 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00687_1 | Factor: alpha-CP1; motif: CAGCCAATGAG; match class: 1 | Factor: alpha-CP1; motif: CAGCCAATGAG; match class: 1 | 4 | 0.006234 | 14 |
| TF | TF:M00446_1 | Factor: Spz1; motif: DNNGGRGGGWWNNNN; match class: 1 | Factor: Spz1; motif: DNNGGRGGGWWNNNN; match class: 1 | 8 | 0.010982 | 14 |
| TF | TF:M12643_1 | Factor: NFYB; motif: RGCCAATSRGNRNNNNSNG; match class: 1 | Factor: NFYB; motif: RGCCAATSRGNRNNNNSNG; match class: 1 | 4 | 0.012060 | 14 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-4733-3p | hsa-mir-4733-3p | hsa-mir-4733-3p | 6 | 0.017640 | 14 |
| MIRNA | MIRNA:hsa-mir-200b | hsa-mir-200b | hsa-mir-200b | 6 | 0.025822 | 14 |
| MIRNA | MIRNA:hsa-mir-200c | hsa-mir-200c | hsa-mir-200c | 6 | 0.025822 | 14 |
| MIRNA | MIRNA:hsa-mir-548b-3p | hsa-mir-548b-3p | hsa-mir-548b-3p | 5 | 0.026195 | 14 |
| MIRNA | MIRNA:hsa-mir-637 | hsa-mir-637 | hsa-mir-637 | 6 | 0.026248 | 14 |
| MIRNA | MIRNA:hsa-mir-873 | hsa-mir-873 | hsa-mir-873 | 6 | 0.026896 | 14 |
| MIRNA | MIRNA:hsa-mir-4733-5p | hsa-mir-4733-5p | hsa-mir-4733-5p | 5 | 0.033038 | 14 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 5 | 0.036628 | 14 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 5 | 0.043305 | 14 |
Community 15
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0001533 | cornified envelope | "A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes)." [GOC:add, PMID:11112355, PMID:11590230, PMID:15803139] | 8 | 8.840390e-18 | 15 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 8 | 3.550197e-08 | 15 |
| GO:CC | GO:0030057 | desmosome | "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181] | 4 | 6.314579e-08 | 15 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 8 | 1.632148e-07 | 15 |
| GO:CC | GO:0070820 | tertiary granule | "A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] | 4 | 6.344503e-05 | 15 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 4 | 1.029868e-04 | 15 |
| GO:CC | GO:0036457 | keratohyalin granule | "A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope." [GOC:krc, PMID:15854042] | 2 | 1.217103e-04 | 15 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 8 | 1.249746e-04 | 15 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 8 | 1.272759e-04 | 15 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 5 | 1.872211e-04 | 15 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 9 | 2.020928e-04 | 15 |
| GO:CC | GO:0101003 | ficolin-1-rich granule membrane | "The lipid bilayer surrounding a ficolin-1-rich granule." [GOC:mec, PMID:23650620] | 3 | 2.474959e-04 | 15 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 9 | 3.259701e-04 | 15 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 7 | 7.246139e-04 | 15 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 7 | 7.968671e-04 | 15 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 7 | 7.993766e-04 | 15 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 7 | 7.993766e-04 | 15 |
| GO:CC | GO:0035578 | azurophil granule lumen | "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] | 3 | 8.721959e-04 | 15 |
| GO:CC | GO:0030667 | secretory granule membrane | "The lipid bilayer surrounding a secretory granule." [GOC:mah] | 4 | 9.160665e-04 | 15 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 8 | 9.361713e-04 | 15 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 4 | 9.622685e-04 | 15 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 4 | 1.022422e-03 | 15 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 4 | 1.034780e-03 | 15 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 5 | 2.745361e-03 | 15 |
| GO:CC | GO:0042582 | azurophil granule | "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule] | 3 | 4.304058e-03 | 15 |
| GO:CC | GO:0005766 | primary lysosome | "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] | 3 | 4.304058e-03 | 15 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 9 | 5.378564e-03 | 15 |
| GO:CC | GO:0005775 | vacuolar lumen | "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] | 3 | 6.718883e-03 | 15 |
| GO:CC | GO:0005912 | adherens junction | "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264] | 3 | 7.767526e-03 | 15 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 9 | 1.065653e-02 | 15 |
| GO:CC | GO:0030659 | cytoplasmic vesicle membrane | "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] | 5 | 1.256409e-02 | 15 |
| GO:CC | GO:0012506 | vesicle membrane | "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] | 5 | 1.349799e-02 | 15 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 8 | 1.760082e-02 | 15 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 6 | 2.543359e-02 | 15 |
| GO:CC | GO:0014704 | intercalated disc | "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910] | 2 | 2.762484e-02 | 15 |
| GO:CC | GO:0071665 | gamma-catenin-TCF7L2 complex | "A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:vk, PMID:14661054] | 1 | 4.994332e-02 | 15 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0461402 | Skin 1; cells in corneal layer[≥Medium] | Skin 1; cells in corneal layer[≥Medium] | 5 | 8.033405e-08 | 15 |
| HPA | HPA:0471402 | Skin 2; cells in corneal layer[≥Medium] | Skin 2; cells in corneal layer[≥Medium] | 5 | 4.594062e-07 | 15 |
| HPA | HPA:0461401 | Skin 1; cells in corneal layer[≥Low] | Skin 1; cells in corneal layer[≥Low] | 5 | 5.427640e-07 | 15 |
| HPA | HPA:0461403 | Skin 1; cells in corneal layer[High] | Skin 1; cells in corneal layer[High] | 4 | 9.547522e-07 | 15 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 7 | 3.096934e-06 | 15 |
| HPA | HPA:0471401 | Skin 2; cells in corneal layer[≥Low] | Skin 2; cells in corneal layer[≥Low] | 5 | 3.992726e-06 | 15 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 7 | 1.260018e-05 | 15 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 7 | 1.664094e-05 | 15 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 7 | 1.815409e-05 | 15 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 7 | 2.638165e-05 | 15 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 5 | 3.042379e-05 | 15 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 7 | 6.754444e-05 | 15 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 5 | 7.475660e-05 | 15 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 5 | 7.475660e-05 | 15 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 6 | 1.456399e-04 | 15 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 6 | 1.958310e-04 | 15 |
| HPA | HPA:0471403 | Skin 2; cells in corneal layer[High] | Skin 2; cells in corneal layer[High] | 3 | 3.042947e-04 | 15 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 4 | 3.316832e-03 | 15 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-6798695 | Neutrophil degranulation | Neutrophil degranulation | 8 | 1.325850e-07 | 15 |
| REAC | REAC:R-HSA-6809371 | Formation of the cornified envelope | Formation of the cornified envelope | 5 | 1.353119e-05 | 15 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 8 | 1.001495e-04 | 15 |
| REAC | REAC:R-HSA-6805567 | Keratinization | Keratinization | 5 | 1.778261e-04 | 15 |
| REAC | REAC:R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | Apoptotic cleavage of cell adhesion proteins | 2 | 1.118270e-02 | 15 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 7 | 1.144242e-02 | 15 |
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 8 | 1.407300e-02 | 15 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011124 | Abnormal epidermal morphology | An abnormality of the morphology of the epidermis. | 5 | 0.000002 | 15 |
| HP | HP:0100792 | Acantholysis | The loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes. | 3 | 0.000054 | 15 |
| HP | HP:0025092 | Epidermal acanthosis | Diffuse hypertrophy or thickening of the stratum spinosum of the epidermis (prickle cell layer of the skin). | 4 | 0.000055 | 15 |
| HP | HP:0040162 | Orthokeratosis | Formation of an anuclear keratin layer | 3 | 0.000509 | 15 |
| HP | HP:0000982 | Palmoplantar keratoderma | Abnormal thickening of the skin of the palms of the hands and the soles of the feet. | 4 | 0.001041 | 15 |
| HP | HP:0008066 | Abnormal blistering of the skin | The presence of one or more bullae on the skin, defined as fluid-filled blisters more than 5 mm in diameter with thin walls. | 4 | 0.001201 | 15 |
| HP | HP:0000972 | Palmoplantar hyperkeratosis | Abnormal thickening of the skin localized to the palm of the hand and the sole of the foot. | 4 | 0.001792 | 15 |
| HP | HP:0010765 | Palmar hyperkeratosis | Abnormal thickening of the skin localized to the palm of the hand. | 4 | 0.001909 | 15 |
| HP | HP:0007556 | Plantar hyperkeratosis | Hyperkeratosis affecting the sole of the foot. | 4 | 0.001969 | 15 |
| HP | HP:0011368 | Epidermal thickening | Thickening of the epidermal layer of the skin. | 5 | 0.002125 | 15 |
| HP | HP:0005597 | Congenital alopecia totalis | Loss of all scalp hair with congenital onset. | 2 | 0.002279 | 15 |
| HP | HP:0008404 | Nail dystrophy | Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate. | 4 | 0.002889 | 15 |
| HP | HP:0001072 | Thickened skin | Laminar thickening of skin. | 5 | 0.003979 | 15 |
| HP | HP:0100872 | Abnormality of the plantar skin of foot | An abnormality of the plantar part of foot, that is of the soles of the feet. | 4 | 0.005649 | 15 |
| HP | HP:0040189 | Scaling skin | Refers to the loss of the outer layer of the epidermis in large, scale-like flakes. | 3 | 0.007186 | 15 |
| HP | HP:0031274 | Hypovolemic shock | A state of shock characterized by decreased circulating blood volume in relation to total vascular capacity. This type of shock is characterized by a reduction of diastolic filling pressures. | 2 | 0.007591 | 15 |
| HP | HP:0010705 | 4-5 finger cutaneous syndactyly | A soft tissue continuity in the anteroposterior axis between the fourth (ring) to the fifth (little) finger that extends distally to at least the level of the proximal interphalangeal joints. | 2 | 0.007591 | 15 |
| HP | HP:0006097 | 3-4 finger osseus syndactyly | Fusion of the third (middle) and fourth (ring) finger, involving soft parts and including fusion of individual finger bones. | 2 | 0.007591 | 15 |
| HP | HP:0010492 | Osseous finger syndactyly | Webbing or fusion of the fingers, involving soft parts and including fusion of individual finger bones. | 2 | 0.011381 | 15 |
| HP | HP:0011663 | Right ventricular cardiomyopathy | Right ventricular dysfunction (global or regional) with functional and morphological right ventricular abnormalities, with or without left ventricular disease. | 2 | 0.015928 | 15 |
| HP | HP:0000962 | Hyperkeratosis | Hyperkeratosis is thickening of the epidermis involving the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum. | 4 | 0.019711 | 15 |
| HP | HP:0006670 | Impaired myocardial contractility | Impaired myocardial contractility | 2 | 0.034090 | 15 |
| HP | HP:0001233 | 2-3 finger cutaneous syndactyly | A soft tissue continuity in the anteroposterior axis between the second to the third fingers that extends distally to at least the level of the proximal interphalangeal joints. | 2 | 0.041650 | 15 |
| HP | HP:0032449 | Abnormal dermoepidermal hemidesmosome morphology | An abnormal structure or appearance of hemidesmosomes, multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane. | 2 | 0.041650 | 15 |
| HP | HP:0031538 | Abnormal dermoepidermal junction morphology | Any anomaly of the structure of the acellular zone that is between the dermis and the epidermis and which functions to bind the epidermis to the dermis and to serve as a selective barrier allowing the control of molecular and cellular exchanges between the two compartments. | 2 | 0.049960 | 15 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043588 | skin development | "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] | 5 | 0.000117 | 15 |
| GO:BP | GO:0008544 | epidermis development | "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] | 5 | 0.000312 | 15 |
| GO:BP | GO:0007155 | cell adhesion | "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] | 7 | 0.000374 | 15 |
| GO:BP | GO:0098609 | cell-cell adhesion | "The attachment of one cell to another cell via adhesion molecules." [GOC:dos] | 6 | 0.000815 | 15 |
| GO:BP | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication | "The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 2 | 0.002712 | 15 |
| GO:BP | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion | "The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 2 | 0.003796 | 15 |
| GO:BP | GO:0002934 | desmosome organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd] | 2 | 0.009933 | 15 |
| GO:BP | GO:0098911 | regulation of ventricular cardiac muscle cell action potential | "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 2 | 0.011917 | 15 |
| GO:BP | GO:0086069 | bundle of His cell to Purkinje myocyte communication | "The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 2 | 0.018947 | 15 |
| GO:BP | GO:0090136 | epithelial cell-cell adhesion | "The attachment of an epithelial cell to another epithelial cell via adhesion molecules." [GOC:ascb_2009, GOC:dph, GOC:tb] | 2 | 0.024530 | 15 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0098632 | cell-cell adhesion mediator activity | "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion] | 3 | 0.000383 | 15 |
| GO:MF | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication | "Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 2 | 0.000396 | 15 |
| GO:MF | GO:0098631 | cell adhesion mediator activity | "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell." [GOC:vw, Wikipedia:Cell_adhesion] | 3 | 0.000843 | 15 |
| GO:MF | GO:0005509 | calcium ion binding | "Binding to a calcium ion (Ca2+)." [GOC:ai] | 5 | 0.002336 | 15 |
| GO:MF | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion | "Binding to a protein or protein complex contributing to the adhesion of two different types of cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 2 | 0.003083 | 15 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | Arrhythmogenic right ventricular cardiomyopathy | 2 | 0.046576 | 15 |
Community 16
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000792 | heterochromatin | "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] | 2 | 0.007661 | 16 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 3 | 0.046900 | 16 |
| GO:CC | GO:0016590 | ACF complex | "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:12192034, PMID:15284901, PMID:16568949, PMID:21810179] | 1 | 0.049978 | 16 |
| GO:CC | GO:0090535 | WICH complex | "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair." [GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179] | 1 | 0.049978 | 16 |
| GO:CC | GO:0090536 | NoRC complex | "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and a Tip5 homolog. In mammals, NoRC is involved in regulation of transcription from RNAP I and RNA polymerase III promoters." [GOC:krc] | 1 | 0.049978 | 16 |
| GO:CC | GO:0031213 | RSF complex | "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters)." [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179] | 1 | 0.049978 | 16 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 3 | 0.010355 | 16 |
| GO:MF | GO:0106228 | peptide glutaryltransferase activity | "Catalysis of the reaction: glutaryl-CoA + L-lysyl-[protein] = CoA + H+ + N6-glutaryl-L-lysyl-[protein]." [GOC:sp, PMID:31542297] | 1 | 0.049724 | 16 |
| GO:MF | GO:0106078 | histone succinyltransferase activity | "Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone." [PMID:29211711] | 1 | 0.049724 | 16 |
| GO:MF | GO:0106075 | peptide N-succinyltransferase activity | "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide." [PMID:29211711] | 1 | 0.049724 | 16 |
| GO:MF | GO:0106229 | histone glutaryltransferase activity | "Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone." [GOC:sp, PMID:31542297] | 1 | 0.049724 | 16 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 3 | 0.012821 | 16 |
| GO:BP | GO:0006338 | chromatin remodeling | "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] | 3 | 0.020416 | 16 |
| GO:BP | GO:0006325 | chromatin organization | "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] | 3 | 0.037038 | 16 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 3 | 0.040141 | 16 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4932 | 7q11 23 copy number variation syndrome | 7q11 23 copy number variation syndrome | 2 | 0.028767 | 16 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | B-WICH complex positively regulates rRNA expression | 2 | 0.035354 | 16 |
| REAC | REAC:R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | Positive epigenetic regulation of rRNA expression | 2 | 0.048311 | 16 |
Community 17
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0016607 | nuclear speck | "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640] | 7 | 3.531610e-09 | 17 |
| GO:CC | GO:0035145 | exon-exon junction complex | "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026] | 4 | 9.212737e-09 | 17 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 7 | 7.026895e-07 | 17 |
| GO:CC | GO:0061574 | ASAP complex | "A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1." [GOC:dph, PMID:12665594, PMID:16314458, PMID:22388736] | 2 | 1.081403e-04 | 17 |
| GO:CC | GO:0034709 | methylosome | "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452] | 2 | 1.403160e-03 | 17 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 8 | 1.692333e-03 | 17 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 8 | 1.312637e-02 | 17 |
| GO:CC | GO:0016592 | mediator complex | "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] | 2 | 1.395198e-02 | 17 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 6 | 2.313991e-02 | 17 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 9 | 0.000008 | 17 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 9 | 0.001209 | 17 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-72163 | mRNA Splicing - Major Pathway | mRNA Splicing - Major Pathway | 4 | 0.000108 | 17 |
| REAC | REAC:R-HSA-72172 | mRNA Splicing | mRNA Splicing | 4 | 0.000124 | 17 |
| REAC | REAC:R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | Processing of Capped Intron-Containing Pre-mRNA | 4 | 0.000377 | 17 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 4 | 0.016182 | 17 |
| REAC | REAC:R-HSA-72165 | mRNA Splicing - Minor Pathway | mRNA Splicing - Minor Pathway | 2 | 0.036662 | 17 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 5 | 0.000260 | 17 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 8 | 0.000415 | 17 |
| HPA | HPA:0050012 | Breast; adipocytes[≥Medium] | Breast; adipocytes[≥Medium] | 7 | 0.000629 | 17 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 6 | 0.000707 | 17 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 6 | 0.000871 | 17 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 8 | 0.001335 | 17 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 7 | 0.002191 | 17 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 6 | 0.002376 | 17 |
| HPA | HPA:0060103 | Bronchus; respiratory epithelial cells[High] | Bronchus; respiratory epithelial cells[High] | 7 | 0.002588 | 17 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 7 | 0.002706 | 17 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 7 | 0.002767 | 17 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 6 | 0.004300 | 17 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 7 | 0.004813 | 17 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 7 | 0.005362 | 17 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 6 | 0.005467 | 17 |
| HPA | HPA:0090183 | Cerebellum; cells in granular layer[High] | Cerebellum; cells in granular layer[High] | 5 | 0.007653 | 17 |
| HPA | HPA:0010012 | Adipose tissue; adipocytes[≥Medium] | Adipose tissue; adipocytes[≥Medium] | 7 | 0.010085 | 17 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 8 | 0.011692 | 17 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 6 | 0.013541 | 17 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 8 | 0.013631 | 17 |
| HPA | HPA:0440343 | Skeletal muscle; myocytes[High] | Skeletal muscle; myocytes[High] | 5 | 0.015657 | 17 |
| HPA | HPA:0440342 | Skeletal muscle; myocytes[≥Medium] | Skeletal muscle; myocytes[≥Medium] | 8 | 0.021106 | 17 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 6 | 0.026602 | 17 |
| HPA | HPA:0510652 | Soft tissue 2; fibroblasts[≥Medium] | Soft tissue 2; fibroblasts[≥Medium] | 7 | 0.029361 | 17 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 8 | 0.031883 | 17 |
| HPA | HPA:0570772 | Testis; peritubular cells[≥Medium] | Testis; peritubular cells[≥Medium] | 4 | 0.033558 | 17 |
| HPA | HPA:0570793 | Testis; round or early spermatids[High] | Testis; round or early spermatids[High] | 5 | 0.033947 | 17 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 8 | 0.036009 | 17 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 8 | 0.038355 | 17 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 7 | 0.038562 | 17 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 8 | 0.041153 | 17 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 4 | 0.041830 | 17 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 6 | 0.043055 | 17 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 4 | 0.043291 | 17 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 8 | 0.043535 | 17 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 7 | 0.043899 | 17 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 7 | 0.045190 | 17 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 5 | 0.047391 | 17 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0008380 | RNA splicing | "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] | 7 | 0.000296 | 17 |
| GO:BP | GO:0006397 | mRNA processing | "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] | 7 | 0.000354 | 17 |
| GO:BP | GO:0016071 | mRNA metabolic process | "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 7 | 0.000852 | 17 |
| GO:BP | GO:1903312 | negative regulation of mRNA metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 3 | 0.006353 | 17 |
| GO:BP | GO:0000398 | mRNA splicing, via spliceosome | "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] | 6 | 0.006790 | 17 |
| GO:BP | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] | 6 | 0.006790 | 17 |
| GO:BP | GO:0000375 | RNA splicing, via transesterification reactions | "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] | 6 | 0.006885 | 17 |
| GO:BP | GO:0048024 | regulation of mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 3 | 0.008418 | 17 |
| GO:BP | GO:0050684 | regulation of mRNA processing | "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] | 3 | 0.014424 | 17 |
| GO:BP | GO:0006396 | RNA processing | "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] | 7 | 0.017560 | 17 |
| GO:BP | GO:0048025 | negative regulation of mRNA splicing, via spliceosome | "Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 2 | 0.030366 | 17 |
| GO:BP | GO:0050686 | negative regulation of mRNA processing | "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing." [GOC:ai] | 2 | 0.033251 | 17 |
| GO:BP | GO:0043484 | regulation of RNA splicing | "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] | 3 | 0.039079 | 17 |
| GO:BP | GO:0033119 | negative regulation of RNA splicing | "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah] | 2 | 0.046096 | 17 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03015 | mRNA surveillance pathway | mRNA surveillance pathway | 3 | 0.000677 | 17 |
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | Nucleocytoplasmic transport | 3 | 0.000965 | 17 |
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 3 | 0.004033 | 17 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2916 | Interactome of polycomb repressive complex 2 PRC2 | Interactome of polycomb repressive complex 2 PRC2 | 2 | 0.003003 | 17 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1068 | 12S U11 snRNP | 12S U11 snRNP | 2 | 0.006639 | 17 |
Community 18
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000439 | transcription factor TFIIH core complex | "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] | 6 | 3.112208e-18 | 18 |
| GO:CC | GO:0005675 | transcription factor TFIIH holo complex | "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] | 6 | 6.224175e-18 | 18 |
| GO:CC | GO:0032806 | carboxy-terminal domain protein kinase complex | "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683] | 6 | 2.610111e-16 | 18 |
| GO:CC | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] | 6 | 1.550016e-15 | 18 |
| GO:CC | GO:0070516 | CAK-ERCC2 complex | "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2." [PMID:8692841, PMID:8692842] | 4 | 5.506697e-13 | 18 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 6 | 7.356922e-13 | 18 |
| GO:CC | GO:0016591 | RNA polymerase II, holoenzyme | "A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters." [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii] | 6 | 3.902736e-12 | 18 |
| GO:CC | GO:0055029 | nuclear DNA-directed RNA polymerase complex | "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu] | 6 | 1.695267e-11 | 18 |
| GO:CC | GO:0000428 | DNA-directed RNA polymerase complex | "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] | 6 | 2.327822e-11 | 18 |
| GO:CC | GO:0030880 | RNA polymerase complex | "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah] | 6 | 2.711221e-11 | 18 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 6 | 6.019057e-11 | 18 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 6 | 1.080814e-10 | 18 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 6 | 2.459028e-09 | 18 |
| GO:CC | GO:0070985 | transcription factor TFIIK complex | "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993] | 3 | 3.048783e-09 | 18 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 6 | 1.039738e-08 | 18 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 6 | 1.823513e-07 | 18 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 6 | 5.044100e-06 | 18 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 6 | 6.361039e-06 | 18 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 6 | 2.739616e-04 | 18 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 7 | 1.517037e-03 | 18 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 6 | 3.077449e-03 | 18 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 7 | 9.633080e-03 | 18 |
| GO:CC | GO:0005669 | transcription factor TFIID complex | "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501] | 2 | 1.449955e-02 | 18 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 7 | 3.628566e-02 | 18 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 7 | 3.628566e-02 | 18 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 7 | 3.628566e-02 | 18 |
| GO:CC | GO:0000112 | nucleotide-excision repair factor 3 complex | "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p)." [GOC:ew, PMID:10915862, PMID:14500720, PMID:7813015] | 1 | 4.984879e-02 | 18 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:107 | TFIIH transcription factor complex | TFIIH transcription factor complex | 6 | 3.258175e-14 | 18 |
| CORUM | CORUM:1036 | TFIIH transcription factor complex | TFIIH transcription factor complex | 6 | 3.258175e-14 | 18 |
| CORUM | CORUM:1009 | TFIIH transcription factor complex | TFIIH transcription factor complex | 6 | 8.143369e-14 | 18 |
| CORUM | CORUM:1029 | TFIIH transcription factor complex | TFIIH transcription factor complex | 6 | 8.143369e-14 | 18 |
| CORUM | CORUM:2660 | CAK-ERCC2 complex | CAK-ERCC2 complex | 4 | 7.384525e-10 | 18 |
| CORUM | CORUM:1030 | CAK-ERCC2 complex | CAK-ERCC2 complex | 4 | 7.384525e-10 | 18 |
| CORUM | CORUM:1008 | CAK complex (Cdk-activating kinase complex) | CAK complex (Cdk-activating kinase complex) | 3 | 6.239924e-07 | 18 |
| CORUM | CORUM:1010 | CAK complex (Cdk-activating kinase complex) | CAK complex (Cdk-activating kinase complex) | 3 | 6.239924e-07 | 18 |
| CORUM | CORUM:2657 | ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex | ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex | 3 | 1.244664e-05 | 18 |
| CORUM | CORUM:1007 | CAK core complex (Cdk-activating kinase core complex) | CAK core complex (Cdk-activating kinase core complex) | 2 | 4.219436e-04 | 18 |
| CORUM | CORUM:103 | RNA polymerase II holoenzyme complex | RNA polymerase II holoenzyme complex | 3 | 5.961075e-04 | 18 |
| CORUM | CORUM:2825 | BRCA1-RNA polymerase II complex | BRCA1-RNA polymerase II complex | 3 | 8.167308e-04 | 18 |
| CORUM | CORUM:1037 | TFIIH transcription factor core complex | TFIIH transcription factor core complex | 2 | 4.206968e-03 | 18 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 6 | 1.505615e-13 | 18 |
| REAC | REAC:R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | RNA Pol II CTD phosphorylation and interaction with CE | 6 | 1.505615e-13 | 18 |
| REAC | REAC:R-HSA-72086 | mRNA Capping | mRNA Capping | 6 | 2.463349e-13 | 18 |
| REAC | REAC:R-HSA-73863 | RNA Polymerase I Transcription Termination | RNA Polymerase I Transcription Termination | 6 | 4.813112e-13 | 18 |
| REAC | REAC:R-HSA-113418 | Formation of the Early Elongation Complex | Formation of the Early Elongation Complex | 6 | 5.923368e-13 | 18 |
| REAC | REAC:R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | Formation of the HIV-1 Early Elongation Complex | 6 | 5.923368e-13 | 18 |
| REAC | REAC:R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | Tat-mediated elongation of the HIV-1 transcript | 6 | 3.426256e-12 | 18 |
| REAC | REAC:R-HSA-167169 | HIV Transcription Elongation | HIV Transcription Elongation | 6 | 3.426256e-12 | 18 |
| REAC | REAC:R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | Formation of HIV-1 elongation complex containing HIV-1 Tat | 6 | 3.426256e-12 | 18 |
| REAC | REAC:R-HSA-5696395 | Formation of Incision Complex in GG-NER | Formation of Incision Complex in GG-NER | 6 | 3.981554e-12 | 18 |
| REAC | REAC:R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | Formation of HIV elongation complex in the absence of HIV Tat | 6 | 4.609860e-12 | 18 |
| REAC | REAC:R-HSA-75953 | RNA Polymerase II Transcription Initiation | RNA Polymerase II Transcription Initiation | 6 | 6.115973e-12 | 18 |
| REAC | REAC:R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | RNA Polymerase II Transcription Initiation And Promoter Clearance | 6 | 6.115973e-12 | 18 |
| REAC | REAC:R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | RNA Polymerase II HIV Promoter Escape | 6 | 6.115973e-12 | 18 |
| REAC | REAC:R-HSA-73776 | RNA Polymerase II Promoter Escape | RNA Polymerase II Promoter Escape | 6 | 6.115973e-12 | 18 |
| REAC | REAC:R-HSA-167161 | HIV Transcription Initiation | HIV Transcription Initiation | 6 | 6.115973e-12 | 18 |
| REAC | REAC:R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 6 | 6.115973e-12 | 18 |
| REAC | REAC:R-HSA-73762 | RNA Polymerase I Transcription Initiation | RNA Polymerase I Transcription Initiation | 6 | 7.010445e-12 | 18 |
| REAC | REAC:R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | Formation of TC-NER Pre-Incision Complex | 6 | 1.037243e-11 | 18 |
| REAC | REAC:R-HSA-75955 | RNA Polymerase II Transcription Elongation | RNA Polymerase II Transcription Elongation | 6 | 2.367368e-11 | 18 |
| REAC | REAC:R-HSA-112382 | Formation of RNA Pol II elongation complex | Formation of RNA Pol II elongation complex | 6 | 2.367368e-11 | 18 |
| REAC | REAC:R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | Gap-filling DNA repair synthesis and ligation in TC-NER | 6 | 3.621223e-11 | 18 |
| REAC | REAC:R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | TP53 Regulates Transcription of DNA Repair Genes | 6 | 3.621223e-11 | 18 |
| REAC | REAC:R-HSA-6782135 | Dual incision in TC-NER | Dual incision in TC-NER | 6 | 4.008898e-11 | 18 |
| REAC | REAC:R-HSA-167172 | Transcription of the HIV genome | Transcription of the HIV genome | 6 | 7.813208e-11 | 18 |
| REAC | REAC:R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6 | 1.311777e-10 | 18 |
| REAC | REAC:R-HSA-674695 | RNA Polymerase II Pre-transcription Events | RNA Polymerase II Pre-transcription Events | 6 | 1.956871e-10 | 18 |
| REAC | REAC:R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | Global Genome Nucleotide Excision Repair (GG-NER) | 6 | 2.646197e-10 | 18 |
| REAC | REAC:R-HSA-73772 | RNA Polymerase I Promoter Escape | RNA Polymerase I Promoter Escape | 6 | 4.051317e-10 | 18 |
| REAC | REAC:R-HSA-427413 | NoRC negatively regulates rRNA expression | NoRC negatively regulates rRNA expression | 6 | 1.045959e-09 | 18 |
| REAC | REAC:R-HSA-5696398 | Nucleotide Excision Repair | Nucleotide Excision Repair | 6 | 1.174396e-09 | 18 |
| REAC | REAC:R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | Negative epigenetic regulation of rRNA expression | 6 | 1.243380e-09 | 18 |
| REAC | REAC:R-HSA-73854 | RNA Polymerase I Promoter Clearance | RNA Polymerase I Promoter Clearance | 6 | 1.315707e-09 | 18 |
| REAC | REAC:R-HSA-73864 | RNA Polymerase I Transcription | RNA Polymerase I Transcription | 6 | 1.391504e-09 | 18 |
| REAC | REAC:R-HSA-162599 | Late Phase of HIV Life Cycle | Late Phase of HIV Life Cycle | 6 | 4.246226e-09 | 18 |
| REAC | REAC:R-HSA-162587 | HIV Life Cycle | HIV Life Cycle | 6 | 7.531275e-09 | 18 |
| REAC | REAC:R-HSA-212165 | Epigenetic regulation of gene expression | Epigenetic regulation of gene expression | 6 | 3.313284e-08 | 18 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 6 | 1.114230e-07 | 18 |
| REAC | REAC:R-HSA-73894 | DNA Repair | DNA Repair | 6 | 1.074206e-06 | 18 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 6 | 1.815970e-06 | 18 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 7 | 5.061597e-05 | 18 |
| REAC | REAC:R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | Cyclin A/B1/B2 associated events during G2/M transition | 3 | 9.385202e-05 | 18 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 7 | 9.757053e-05 | 18 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 6 | 1.078303e-04 | 18 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 4 | 1.505016e-04 | 18 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 7 | 2.164567e-04 | 18 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 4 | 2.455846e-04 | 18 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 6 | 3.690800e-04 | 18 |
| REAC | REAC:R-HSA-5696400 | Dual Incision in GG-NER | Dual Incision in GG-NER | 3 | 3.832197e-04 | 18 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 3 | 5.819629e-04 | 18 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 3 | 5.819629e-04 | 18 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 6 | 1.180864e-03 | 18 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 3 | 3.148157e-03 | 18 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 3 | 3.385329e-03 | 18 |
| REAC | REAC:R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3 | 1.226515e-02 | 18 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 3 | 2.418750e-02 | 18 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 6 | 3.029744e-02 | 18 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 3 | 4.257518e-02 | 18 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 4 | 4.380680e-02 | 18 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 3 | 4.387450e-02 | 18 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03022 | Basal transcription factors | Basal transcription factors | 6 | 3.991876e-12 | 18 |
| KEGG | KEGG:03420 | Nucleotide excision repair | Nucleotide excision repair | 6 | 3.629085e-11 | 18 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 3 | 1.000271e-02 | 18 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP405 | Eukaryotic transcription initiation | Eukaryotic transcription initiation | 6 | 5.964311e-12 | 18 |
| WP | WP:WP4753 | Nucleotide excision repair | Nucleotide excision repair | 6 | 8.085155e-12 | 18 |
| WP | WP:WP5114 | Nucleotide excision repair in xeroderma pigmentosum | Nucleotide excision repair in xeroderma pigmentosum | 6 | 2.449316e-10 | 18 |
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 6 | 4.567677e-09 | 18 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 3 | 1.514818e-03 | 18 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 3 | 1.001537e-02 | 18 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006367 | transcription initiation at RNA polymerase II promoter | "A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH] | 6 | 1.842475e-09 | 18 |
| GO:BP | GO:0006352 | DNA-templated transcription initiation | "The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161] | 6 | 6.415942e-09 | 18 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 6 | 9.341095e-08 | 18 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 6 | 4.662218e-07 | 18 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 6 | 4.728310e-07 | 18 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 6 | 1.093138e-06 | 18 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 6 | 1.748371e-06 | 18 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 6 | 4.424519e-06 | 18 |
| GO:BP | GO:0006289 | nucleotide-excision repair | "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] | 4 | 7.829063e-06 | 18 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 6 | 1.073890e-05 | 18 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 6 | 1.317502e-05 | 18 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 6 | 3.870418e-05 | 18 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 6 | 4.304463e-05 | 18 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 6 | 7.894203e-05 | 18 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 6 | 1.260850e-04 | 18 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 4 | 2.829725e-04 | 18 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 6 | 3.340889e-04 | 18 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 4 | 4.758160e-04 | 18 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 6 | 1.584590e-03 | 18 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 6 | 2.795405e-03 | 18 |
| GO:BP | GO:0006283 | transcription-coupled nucleotide-excision repair | "The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [PMID:10197977, PMID:11900249] | 2 | 4.269905e-03 | 18 |
| GO:BP | GO:0009650 | UV protection | "Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml] | 2 | 5.217945e-03 | 18 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 1.219746e-02 | 18 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 1.968844e-02 | 18 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 6 | 2.847623e-02 | 18 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 3 | 0.000235 | 18 |
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 3 | 0.000235 | 18 |
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 3 | 0.001114 | 18 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 4 | 0.002683 | 18 |
| GO:MF | GO:0140097 | catalytic activity, acting on DNA | "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] | 3 | 0.010193 | 18 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 4 | 0.010381 | 18 |
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 2 | 0.016577 | 18 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 4 | 0.018078 | 18 |
| GO:MF | GO:0003678 | DNA helicase activity | "Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl] | 2 | 0.025099 | 18 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 4 | 0.026539 | 18 |
| GO:MF | GO:0003684 | damaged DNA binding | "Binding to damaged DNA." [GOC:jl] | 2 | 0.041690 | 18 |
| GO:MF | GO:0016772 | transferase activity, transferring phosphorus-containing groups | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] | 4 | 0.049714 | 18 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0010649 | Flat nasal alae | An abnormal degree of flatness of the Ala of nose, which can be defined as a reduced nasal elevation index (lateral depth of the nose from the tip of the nose to the insertion of the nasal ala in the cheek x 100 divided by the side-to-side breadth of the nasal alae). | 2 | 0.001014 | 18 |
| HP | HP:0004337 | Abnormality of amino acid metabolism | Abnormality of an amino acid metabolic process. | 2 | 0.001014 | 18 |
| HP | HP:0410219 | Hypoplasia of mandible relative to maxilla | Abnormally small dimension of the mandible (lower jaw) relative to the maxilla (upper jaw). | 2 | 0.001304 | 18 |
| HP | HP:0007381 | Congenital exfoliative erythroderma | Congenital exfoliative erythroderma | 2 | 0.001304 | 18 |
| HP | HP:0045055 | Tiger tail banding | An abnormal appearance of hair under polarizing microscopy (using crossed polarizers), whereby hair shafts show striking alternating bright and dark bands, often referred to as tiger tail banding. | 2 | 0.001630 | 18 |
| HP | HP:0001809 | Split nail | A nail plate that has a longitudinal separation and the two sections of the nail share the same lateral radius of curvature. | 2 | 0.001992 | 18 |
| HP | HP:0002562 | Low-set nipples | Placement of the nipples at a lower than normal location. | 2 | 0.002391 | 18 |
| HP | HP:0007587 | Numerous pigmented freckles | Numerous pigmented freckles | 2 | 0.002391 | 18 |
| HP | HP:0003079 | Defective DNA repair after ultraviolet radiation damage | Defective DNA repair after ultraviolet radiation damage | 2 | 0.003803 | 18 |
| HP | HP:0006538 | Recurrent bronchopulmonary infections | An increased susceptibility to bronchopulmonary infections as manifested by a history of recurrent bronchopulmonary infections. | 2 | 0.003803 | 18 |
| HP | HP:0009755 | Ankyloblepharon | Partial fusion of the upper and lower eyelid margins by single or multiple bands of tissue. | 2 | 0.004347 | 18 |
| HP | HP:0025548 | Increased mean corpuscular hemoglobin concentration | An elevation over the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). | 2 | 0.004347 | 18 |
| HP | HP:0007034 | Generalized hyperreflexia | Generalized hyperreflexia | 2 | 0.004347 | 18 |
| HP | HP:0000320 | Bird-like facies | Bird-like facies | 2 | 0.005542 | 18 |
| HP | HP:0007485 | Absence of subcutaneous fat | Lack of subcutaneous adipose tissue. | 2 | 0.005542 | 18 |
| HP | HP:0007266 | Cerebral dysmyelination | Defective structure and function of myelin sheaths of the white matter of the brain. | 2 | 0.006194 | 18 |
| HP | HP:0001598 | Concave nail | The natural longitudinal (posterodistal) convex arch is not present or is inverted. | 2 | 0.006194 | 18 |
| HP | HP:0003254 | Abnormality of DNA repair | An abnormality of the process of DNA repair, that is, of the process of restoring DNA after damage. | 2 | 0.006194 | 18 |
| HP | HP:0000621 | Entropion | An abnormal inversion (turning inward) of the eyelid (usually the lower) towards the globe. Entropion is usually acquired as a result of involutional or cicatricial processes but may occasionally be congenital. | 2 | 0.006882 | 18 |
| HP | HP:0025546 | Abnormal mean corpuscular hemoglobin concentration | A deviation from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced. | 2 | 0.007607 | 18 |
| HP | HP:0100275 | Diffuse cerebellar atrophy | Diffuse unlocalised atrophy affecting the cerebellum. | 2 | 0.007607 | 18 |
| HP | HP:0006739 | Squamous cell carcinoma of the skin | Squamous cell carcinoma of the skin is a malignant tumor of squamous epithelium. | 2 | 0.008367 | 18 |
| HP | HP:0000524 | Conjunctival telangiectasia | The presence of small (ca. 0.5-1.0 mm) dilated blood vessels near the surface of the mucous membranes of the conjunctiva. | 2 | 0.009164 | 18 |
| HP | HP:0003139 | Panhypogammaglobulinemia | A reduction in the circulating levels of all the major classes of immunoglobulin. is characterized by profound decreases in all classes of immunoglobulin with an absence of circulating B lymphocytes. | 2 | 0.009997 | 18 |
| HP | HP:0007479 | Congenital nonbullous ichthyosiform erythroderma | The term collodion baby applies to newborns who appear to have an extra layer of skin (known as a collodion membrane) that has a collodion-like quality. It is a descriptive term, not a specific diagnosis or disorder (as such, it is a syndrome). Affected babies are born in a collodion membrane, a shiny waxy outer layer to the skin. This is shed 10-14 days after birth, revealing the main symptom of the disease, extensive scaling of the skin caused by hyperkeratosis. With increasing age, the scaling tends to be concentrated around joints in areas such as the groin, the armpits, the inside of the elbow and the neck. The scales often tile the skin and may resemble fish scales. | 2 | 0.009997 | 18 |
| HP | HP:4000007 | Bronchoconstriction | Tightening of smooth muscle surrounding the bronchi and bronchioles with consequent wheezing and shortness of breath. | 2 | 0.009997 | 18 |
| HP | HP:0001029 | Poikiloderma | Poikiloderma refers to a patch of skin with (1) reticulated hypopigmentation and hyperpigmentation, (2) wrinkling secondary to epidermal atrophy, and (3) telangiectasias. | 2 | 0.010867 | 18 |
| HP | HP:0025427 | Abnormal bronchus physiology | Any anomaly of the function of the bronchi. | 2 | 0.010867 | 18 |
| HP | HP:0007633 | Bilateral microphthalmos | A developmental anomaly characterized by abnormal smallness of both eyes. | 2 | 0.011772 | 18 |
| HP | HP:0008054 | Abnormal morphology of the conjunctival vasculature | Any abnormality of the blood vessels of the conjunctiva. | 2 | 0.012714 | 18 |
| HP | HP:0004493 | Craniofacial hyperostosis | Excessive growth of the craniofacial bones. | 2 | 0.012714 | 18 |
| HP | HP:0001808 | Fragile nails | Nails that easily break. | 2 | 0.017966 | 18 |
| HP | HP:0008391 | Dystrophic fingernails | The presence of misshapen or partially destroyed nail plates, often with accumulation of soft, yellow keratin between the dystrophic nail plate and nail bed, resulting in elevation of the nail plate. | 2 | 0.017966 | 18 |
| HP | HP:0007431 | Congenital ichthyosiform erythroderma | An ichthyosiform abnormality of the skin with congenital onset. | 2 | 0.019125 | 18 |
| HP | HP:0008887 | Adipose tissue loss | A reduction in the amount of adipose tissue (fat) compared with the amount previously present in an individual. | 2 | 0.020321 | 18 |
| HP | HP:0001807 | Ridged nail | Longitudinal, linear prominences in the nail plate. | 2 | 0.020321 | 18 |
| HP | HP:0003328 | Abnormal hairshaft morphology | An abnormal structure of the hairshaft, i.e., of the nongrowing portion of a hair that protrudes from the skin. | 2 | 0.022820 | 18 |
| HP | HP:0000133 | Gonadal dysgenesis | Gonadal dysgenesis is the name given to any of a multitude of conditions that can cause impaired development of the gonads, i.e., the testes or ovaries, or to the related phenotypic features. The term is to be avoided if possible for new annotations, and more specific terms should be chosen. | 2 | 0.024124 | 18 |
| HP | HP:0006887 | Intellectual disability, progressive | The term progressive intellectual disability should be used if intelligence decreases/deteriorates over time. | 2 | 0.026841 | 18 |
| HP | HP:0100579 | Mucosal telangiectasiae | Telangiectasia of the mucosa, the mucous membranes which are involved in absorption and secretion that line cavities that are exposed to the external environment and internal organs. | 2 | 0.029702 | 18 |
| HP | HP:0025757 | Abnormal nail surface | An anomaly of the surface of the nail. | 2 | 0.029702 | 18 |
| HP | HP:0004437 | Cranial hyperostosis | Excessive growth of the bones of cranium, i.e., of the skull. | 2 | 0.032709 | 18 |
| HP | HP:0002293 | Alopecia of scalp | Alopecia of scalp | 2 | 0.035860 | 18 |
| HP | HP:0001480 | Freckling | The presence of an increased number of freckles, small circular spots on the skin that are darker than the surrounding skin because of deposits of melanin. | 2 | 0.040859 | 18 |
| HP | HP:0100012 | Neoplasm of the eye | A tumor (abnormal growth of tissue) of the eye. | 2 | 0.042597 | 18 |
| HP | HP:0001059 | Pterygium | Pterygia are 'winglike' triangular membranes occurring in the neck, eyes, knees, elbows, ankles or digits. | 2 | 0.044372 | 18 |
| HP | HP:0000498 | Blepharitis | Inflammation of the eyelids. | 2 | 0.048031 | 18 |
| HP | HP:0006970 | Periventricular leukomalacia | Periventricular leukomalacia is characterized by diffuse injury of deep cerebral white matter, accompanied in its most severe form by focal necrosis. The neuropathologic hallmarks of PVL are microglial activation and focal and diffuse periventricular depletion of premyelinating oligodendroglia. | 2 | 0.049914 | 18 |
| HP | HP:0100774 | Hyperostosis | Excessive growth or abnormal thickening of bone tissue. | 2 | 0.049914 | 18 |
| HP | HP:0040063 | Decreased adipose tissue | The amount of adipose tissue (fat) in the body or a part of the body is below the lower limit of normal. | 2 | 0.049914 | 18 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0460663 | Skin 1; keratinocytes[High] | Skin 1; keratinocytes[High] | 4 | 0.034727 | 18 |
Community 19
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005852 | eukaryotic translation initiation factor 3 complex | "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] | 6 | 1.888466e-16 | 19 |
| GO:CC | GO:0033290 | eukaryotic 48S preinitiation complex | "The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC." [GOC:hjd, PMID:16510876, PMID:24319994, PMID:24499181, PMID:29735639] | 6 | 2.918312e-16 | 19 |
| GO:CC | GO:0016282 | eukaryotic 43S preinitiation complex | "A protein complex composed of the 40S ribosomal subunit plus eIF1, eIF1A, eIF3, eIF5, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049, PMID:16510876, PMID:25742741, PMID:29735639] | 6 | 4.377129e-16 | 19 |
| GO:CC | GO:0070993 | cytosolic translation preinitiation complex | "A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA." [GOC:hjd, GOC:mah] | 6 | 6.396847e-16 | 19 |
| GO:CC | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m | "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185] | 3 | 1.494070e-07 | 19 |
| GO:CC | GO:0071540 | eukaryotic translation initiation factor 3 complex, eIF3e | "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e." [PMID:15904532, PMID:19061185] | 2 | 1.576743e-05 | 19 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 8 | 2.089741e-03 | 19 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 6 | 1.068861e-02 | 19 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 5 | 4.730967e-02 | 19 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003743 | translation initiation factor activity | "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] | 7 | 5.953252e-16 | 19 |
| GO:MF | GO:0180051 | translation factor activity | "A molecular function required for translation of a mRNA into a protein functioning as part of initiation, elongation or termination of translation." [GOC:pg] | 7 | 3.120883e-14 | 19 |
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 7 | 1.781794e-03 | 19 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002183 | cytoplasmic translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] | 7 | 1.236616e-15 | 19 |
| GO:BP | GO:0001732 | formation of cytoplasmic translation initiation complex | "Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd, PMID:29735639] | 6 | 1.946072e-15 | 19 |
| GO:BP | GO:0006413 | translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] | 7 | 2.057488e-12 | 19 |
| GO:BP | GO:0002181 | cytoplasmic translation | "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] | 7 | 1.334945e-11 | 19 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 7 | 4.644064e-07 | 19 |
| GO:BP | GO:1902416 | positive regulation of mRNA binding | "Any process that activates or increases the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846] | 2 | 7.914256e-04 | 19 |
| GO:BP | GO:1902415 | regulation of mRNA binding | "Any process that modulates the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846] | 2 | 7.914256e-04 | 19 |
| GO:BP | GO:1905216 | positive regulation of RNA binding | "Any process that activates or increases the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364] | 2 | 1.318792e-03 | 19 |
| GO:BP | GO:0022618 | protein-RNA complex assembly | "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] | 6 | 4.593247e-03 | 19 |
| GO:BP | GO:0071826 | protein-RNA complex organization | "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah] | 6 | 4.766364e-03 | 19 |
| GO:BP | GO:0022613 | ribonucleoprotein complex biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] | 6 | 1.145380e-02 | 19 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-72702 | Ribosomal scanning and start codon recognition | Ribosomal scanning and start codon recognition | 7 | 2.031704e-14 | 19 |
| REAC | REAC:R-HSA-72649 | Translation initiation complex formation | Translation initiation complex formation | 7 | 2.031704e-14 | 19 |
| REAC | REAC:R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 7 | 2.300042e-14 | 19 |
| REAC | REAC:R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | L13a-mediated translational silencing of Ceruloplasmin expression | 7 | 2.157539e-12 | 19 |
| REAC | REAC:R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | GTP hydrolysis and joining of the 60S ribosomal subunit | 7 | 2.300018e-12 | 19 |
| REAC | REAC:R-HSA-72613 | Eukaryotic Translation Initiation | Eukaryotic Translation Initiation | 7 | 3.542762e-12 | 19 |
| REAC | REAC:R-HSA-72737 | Cap-dependent Translation Initiation | Cap-dependent Translation Initiation | 7 | 3.542762e-12 | 19 |
| REAC | REAC:R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Formation of the ternary complex, and subsequently, the 43S complex | 6 | 1.328666e-11 | 19 |
| REAC | REAC:R-HSA-72689 | Formation of a pool of free 40S subunits | Formation of a pool of free 40S subunits | 6 | 8.753665e-10 | 19 |
| REAC | REAC:R-HSA-72766 | Translation | Translation | 7 | 1.989286e-09 | 19 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 7 | 1.866507e-03 | 19 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5027 | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell | 6 | 4.713121e-14 | 19 |
| WP | WP:WP107 | Translation factors | Translation factors | 7 | 1.341164e-13 | 19 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:742 | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) | 6 | 3.581262e-13 | 19 |
| CORUM | CORUM:1097 | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) | 6 | 6.649224e-13 | 19 |
| CORUM | CORUM:4403 | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J) | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J) | 3 | 6.228851e-06 | 19 |
| CORUM | CORUM:4392 | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) | 3 | 6.228851e-06 | 19 |
| CORUM | CORUM:4399 | EIF3 complex (EIF3B, EIF3J, EIF3I) | EIF3 complex (EIF3B, EIF3J, EIF3I) | 2 | 1.264583e-03 | 19 |
| CORUM | CORUM:4389 | EIF3 core complex (EIF3A, EIF3B, EIF3G, EIF3I) | EIF3 core complex (EIF3A, EIF3B, EIF3G, EIF3I) | 2 | 2.526672e-03 | 19 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-155-5p | hsa-mir-155-5p | hsa-mir-155-5p | 5 | 0.007747 | 19 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00178 | Factor: CREB; motif: NSTGACGTMANN | Factor: CREB; motif: NSTGACGTMANN | 8 | 0.032811 | 19 |
Community 20
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00480 | Glutathione metabolism | Glutathione metabolism | 3 | 0.000132 | 20 |
| KEGG | KEGG:01230 | Biosynthesis of amino acids | Biosynthesis of amino acids | 2 | 0.036173 | 20 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016491 | oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-] | 5 | 0.000498 | 20 |
| GO:MF | GO:0004602 | glutathione peroxidase activity | "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9, PMID:36771108] | 2 | 0.004203 | 20 |
| GO:MF | GO:0004601 | peroxidase activity | "Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators] | 2 | 0.028836 | 20 |
| GO:MF | GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor | "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [EC:1.11.-.-] | 2 | 0.030902 | 20 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 3 | 0.031604 | 20 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 6 | 0.002430 | 20 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 6 | 0.002639 | 20 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 6 | 0.002646 | 20 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 6 | 0.002646 | 20 |
| GO:CC | GO:0034707 | chloride channel complex | "An ion channel complex through which chloride ions pass." [GOC:mah] | 2 | 0.023191 | 20 |
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 5 | 0.024836 | 20 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 6 | 0.032935 | 20 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 4 | 0.021169 | 20 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0019362 | pyridine nucleotide metabolic process | "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] | 3 | 0.025458 | 20 |
| GO:BP | GO:0046496 | nicotinamide nucleotide metabolic process | "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] | 3 | 0.025458 | 20 |
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 3 | 0.028889 | 20 |
| GO:BP | GO:0032787 | monocarboxylic acid metabolic process | "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] | 4 | 0.048432 | 20 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-3299685 | Detoxification of Reactive Oxygen Species | Detoxification of Reactive Oxygen Species | 2 | 0.03294 | 20 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 4 | 0.041830 | 20 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 4 | 0.046949 | 20 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 4 | 0.047898 | 20 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6948 | Isocitrate dehydrogenase [NADP], mitochondrial | Isocitrate dehydrogenase [NADP], mitochondrial | 1 | 0.049932 | 20 |
Community 21
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 3 | 3.753502e-07 | 21 |
| REAC | REAC:R-HSA-156711 | Polo-like kinase mediated events | Polo-like kinase mediated events | 3 | 3.753502e-07 | 21 |
| REAC | REAC:R-HSA-1538133 | G0 and Early G1 | G0 and Early G1 | 3 | 2.144858e-06 | 21 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 3 | 4.367229e-04 | 21 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 3 | 1.019451e-03 | 21 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 3 | 1.051142e-03 | 21 |
| REAC | REAC:R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | Transcription of E2F targets under negative control by DREAM complex | 2 | 1.387289e-03 | 21 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 2 | 3.180868e-03 | 21 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 3 | 2.262634e-02 | 21 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 2 | 2.999545e-02 | 21 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 2 | 3.148190e-02 | 21 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 3 | 4.285112e-02 | 21 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0031523 | Myb complex | "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624] | 2 | 0.000041 | 21 |
| GO:CC | GO:0033186 | CAF-1 complex | "A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276] | 2 | 0.000041 | 21 |
| GO:CC | GO:0017053 | transcription repressor complex | "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] | 2 | 0.041127 | 21 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2234 | Chromatin assembly complex (CAF-1 complex) | Chromatin assembly complex (CAF-1 complex) | 2 | 0.000132 | 21 |
| CORUM | CORUM:1259 | Chromatin assembly complex (CAF-1 complex) | Chromatin assembly complex (CAF-1 complex) | 2 | 0.000132 | 21 |
| CORUM | CORUM:5593 | LINC core complex | LINC core complex | 2 | 0.000264 | 21 |
| CORUM | CORUM:2235 | ASF1-interacting protein complex | ASF1-interacting protein complex | 2 | 0.000440 | 21 |
| CORUM | CORUM:5589 | LINC complex, S-phase | LINC complex, S-phase | 2 | 0.000440 | 21 |
| CORUM | CORUM:5596 | LINC complex, quiescent cells | LINC complex, quiescent cells | 2 | 0.000660 | 21 |
| CORUM | CORUM:1149 | Histone H3.1 complex | Histone H3.1 complex | 2 | 0.001231 | 21 |
| CORUM | CORUM:839 | LIN9-BMYB complex | LIN9-BMYB complex | 1 | 0.049680 | 21 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006335 | DNA replication-dependent chromatin assembly | "The formation of nucleosomes on newly synthesized DNA, coupled to strand elongation." [GOC:mah, PMID:28053344] | 2 | 0.001424 | 21 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 5 | 0.004787 | 21 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 3 | 0.002854 | 21 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2361 | Gastric cancer network 1 | Gastric cancer network 1 | 2 | 0.009435 | 21 |
| WP | WP:WP5180 | DYRK1A involvement regarding cell proliferation in brain development | DYRK1A involvement regarding cell proliferation in brain development | 2 | 0.046833 | 21 |
Community 22
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:726 | DDB2 complex | DDB2 complex | 2 | 0.001947 | 22 |
| CORUM | CORUM:727 | CSA complex | CSA complex | 2 | 0.001947 | 22 |
| CORUM | CORUM:728 | CSA-POLIIa complex | CSA-POLIIa complex | 2 | 0.001947 | 22 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | Caspase-mediated cleavage of cytoskeletal proteins | 2 | 0.003674 | 22 |
| REAC | REAC:R-HSA-111465 | Apoptotic cleavage of cellular proteins | Apoptotic cleavage of cellular proteins | 2 | 0.036852 | 22 |
| REAC | REAC:R-HSA-5696394 | DNA Damage Recognition in GG-NER | DNA Damage Recognition in GG-NER | 2 | 0.038890 | 22 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-let-7e-3p | hsa-let-7e-3p | hsa-let-7e-3p | 2 | 0.005407 | 22 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | Human immunodeficiency virus 1 infection | 3 | 0.007065 | 22 |
| KEGG | KEGG:04623 | Cytosolic DNA-sensing pathway | Cytosolic DNA-sensing pathway | 2 | 0.044392 | 22 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045116 | protein neddylation | "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580] | 2 | 0.024516 | 22 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 6 | 0.045087 | 22 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008832 | dGTPase activity | "Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate." [RHEA:15193] | 1 | 0.049891 | 22 |
| GO:MF | GO:0016793 | triphosphoric monoester hydrolase activity | "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [EC:3.1.5.-] | 1 | 0.049891 | 22 |
| GO:MF | GO:0032560 | guanyl deoxyribonucleotide binding | "Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] | 1 | 0.049891 | 22 |
| GO:MF | GO:0032567 | dGTP binding | "Binding to dGTP, deoxyguanosine triphosphate." [GOC:mah] | 1 | 0.049891 | 22 |
| GO:MF | GO:0106375 | deoxynucleoside triphosphate hydrolase activity | "Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate." [RHEA:46148] | 1 | 0.049891 | 22 |
Community 23
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0033919 | glucan 1,3-alpha-glucosidase activity | "Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans." [EC:3.2.1.84] | 1 | 0.049891 | 23 |
Community 24
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005862 | muscle thin filament tropomyosin | "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194] | 4 | 2.760606e-13 | 24 |
| GO:CC | GO:0005865 | striated muscle thin filament | "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] | 4 | 2.441162e-09 | 24 |
| GO:CC | GO:0036379 | myofilament | "Any of the smallest contractile units of a myofibril (striated muscle fiber)." [Wikipedia:Myofilament] | 4 | 4.836815e-09 | 24 |
| GO:CC | GO:0005884 | actin filament | "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] | 5 | 5.363189e-09 | 24 |
| GO:CC | GO:0030017 | sarcomere | "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] | 5 | 9.689569e-08 | 24 |
| GO:CC | GO:0030016 | myofibril | "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] | 5 | 1.572411e-07 | 24 |
| GO:CC | GO:0043292 | contractile muscle fiber | "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] | 5 | 1.930980e-07 | 24 |
| GO:CC | GO:0097517 | contractile actin filament bundle | "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194] | 4 | 5.827619e-07 | 24 |
| GO:CC | GO:0001725 | stress fiber | "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] | 4 | 5.827619e-07 | 24 |
| GO:CC | GO:0042641 | actomyosin | "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] | 4 | 8.008493e-07 | 24 |
| GO:CC | GO:0032432 | actin filament bundle | "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] | 4 | 8.730827e-07 | 24 |
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 5 | 8.677507e-06 | 24 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 5 | 7.465883e-05 | 24 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 5 | 2.745562e-04 | 24 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 5 | 2.849250e-04 | 24 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 5 | 1.242137e-03 | 24 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 5 | 1.739673e-02 | 24 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 6 | 4.479479e-02 | 24 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0051015 | actin filament binding | "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] | 5 | 1.119493e-07 | 24 |
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 5 | 4.811168e-06 | 24 |
| GO:MF | GO:0008307 | structural constituent of muscle | "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] | 3 | 2.782912e-05 | 24 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 5 | 2.834813e-04 | 24 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 5 | 1.092677e-03 | 24 |
| GO:MF | GO:0042803 | protein homodimerization activity | "Binding to an identical protein to form a homodimer." [GOC:jl] | 4 | 4.016696e-03 | 24 |
| GO:MF | GO:0046982 | protein heterodimerization activity | "Binding to a nonidentical protein to form a heterodimer." [GOC:ai] | 3 | 1.848984e-02 | 24 |
| GO:MF | GO:0005198 | structural molecule activity | "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] | 4 | 2.046902e-02 | 24 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 4 | 2.195611e-02 | 24 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-390522 | Striated Muscle Contraction | Striated Muscle Contraction | 4 | 3.244012e-07 | 24 |
| REAC | REAC:R-HSA-445355 | Smooth Muscle Contraction | Smooth Muscle Contraction | 4 | 6.789492e-07 | 24 |
| REAC | REAC:R-HSA-397014 | Muscle contraction | Muscle contraction | 4 | 3.691110e-04 | 24 |
| REAC | REAC:R-HSA-9012999 | RHO GTPase cycle | RHO GTPase cycle | 4 | 8.656713e-03 | 24 |
| REAC | REAC:R-HSA-9013424 | RHOV GTPase cycle | RHOV GTPase cycle | 2 | 3.685223e-02 | 24 |
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 4 | 4.974582e-02 | 24 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP383 | Striated muscle contraction pathway | Striated muscle contraction pathway | 4 | 4.949592e-07 | 24 |
| WP | WP:WP2005 | miR targeted genes in muscle cell | miR targeted genes in muscle cell | 4 | 3.888758e-03 | 24 |
| WP | WP:WP2004 | miR targeted genes in lymphocytes | miR targeted genes in lymphocytes | 4 | 8.055559e-03 | 24 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04260 | Cardiac muscle contraction | Cardiac muscle contraction | 4 | 0.000007 | 24 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | Hypertrophic cardiomyopathy | 4 | 0.000012 | 24 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | Dilated cardiomyopathy | 4 | 0.000014 | 24 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | Adrenergic signaling in cardiomyocytes | 4 | 0.000073 | 24 |
| KEGG | KEGG:04814 | Motor proteins | Motor proteins | 4 | 0.000184 | 24 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 5 | 0.000026 | 24 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 5 | 0.000257 | 24 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 5 | 0.000476 | 24 |
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 5 | 0.000589 | 24 |
| GO:BP | GO:0006936 | muscle contraction | "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] | 4 | 0.000973 | 24 |
| GO:BP | GO:0003012 | muscle system process | "An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] | 4 | 0.002407 | 24 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 5 | 0.010174 | 24 |
| GO:BP | GO:0030220 | platelet formation | "The process in which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194] | 2 | 0.018124 | 24 |
| GO:BP | GO:0036344 | platelet morphogenesis | "Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk] | 2 | 0.021200 | 24 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-1-3p | hsa-mir-1-3p | hsa-mir-1-3p | 5 | 0.000914 | 24 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12092 | Factor: ZNF787; motif: TGCCTCAGTTTMCCN | Factor: ZNF787; motif: TGCCTCAGTTTMCCN | 4 | 0.015852 | 24 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002068 | Neuromuscular dysphagia | Neuromuscular dysphagia | 2 | 0.04165 | 24 |
| HP | HP:0004878 | Intercostal muscle weakness | Lack of strength of the intercostal muscles, i.e., of the muscle groups running along the ribs that create and move the chest wall. | 2 | 0.04165 | 24 |
| HP | HP:0007110 | Central hypoventilation | Central hypoventilation | 2 | 0.04996 | 24 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0440343 | Skeletal muscle; myocytes[High] | Skeletal muscle; myocytes[High] | 4 | 0.048249 | 24 |
Community 25
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP534 | Glycolysis and gluconeogenesis | Glycolysis and gluconeogenesis | 5 | 1.877493e-09 | 25 |
| WP | WP:WP4018 | Clear cell renal cell carcinoma pathways | Clear cell renal cell carcinoma pathways | 5 | 5.021368e-08 | 25 |
| WP | WP:WP5355 | Metabolic epileptic disorders | Metabolic epileptic disorders | 5 | 7.114961e-08 | 25 |
| WP | WP:WP5049 | Glycolysis in senescence | Glycolysis in senescence | 3 | 3.240089e-06 | 25 |
| WP | WP:WP4236 | Krebs cycle disorders | Krebs cycle disorders | 3 | 5.613264e-06 | 25 |
| WP | WP:WP4628 | Aerobic glycolysis augmented | Aerobic glycolysis augmented | 3 | 5.613264e-06 | 25 |
| WP | WP:WP4290 | Metabolic reprogramming in colon cancer | Metabolic reprogramming in colon cancer | 3 | 2.236383e-04 | 25 |
| WP | WP:WP5211 | Glucose metabolism in triple negative breast cancer cells | Glucose metabolism in triple negative breast cancer cells | 2 | 1.203036e-03 | 25 |
| WP | WP:WP3925 | Amino acid metabolism | Amino acid metabolism | 3 | 2.336833e-03 | 25 |
| WP | WP:WP5314 | Lactate shuttle in glial cells | Lactate shuttle in glial cells | 2 | 3.346208e-03 | 25 |
| WP | WP:WP1946 | Cori cycle | Cori cycle | 2 | 5.827301e-03 | 25 |
| WP | WP:WP4595 | Urea cycle and associated pathways | Urea cycle and associated pathways | 2 | 1.180077e-02 | 25 |
| WP | WP:WP3614 | Photodynamic therapy induced HIF 1 survival signaling | Photodynamic therapy induced HIF 1 survival signaling | 2 | 2.836300e-02 | 25 |
| WP | WP:WP5220 | Metabolic reprogramming in pancreatic cancer | Metabolic reprogramming in pancreatic cancer | 2 | 3.661154e-02 | 25 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00010 | Glycolysis / Gluconeogenesis | Glycolysis / Gluconeogenesis | 5 | 7.716634e-09 | 25 |
| KEGG | KEGG:00620 | Pyruvate metabolism | Pyruvate metabolism | 4 | 6.030537e-07 | 25 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | HIF-1 signaling pathway | 4 | 1.858917e-05 | 25 |
| KEGG | KEGG:01200 | Carbon metabolism | Carbon metabolism | 4 | 2.307400e-05 | 25 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | Central carbon metabolism in cancer | 3 | 5.181640e-04 | 25 |
| KEGG | KEGG:01230 | Biosynthesis of amino acids | Biosynthesis of amino acids | 3 | 6.129640e-04 | 25 |
| KEGG | KEGG:01100 | Metabolic pathways | Metabolic pathways | 6 | 1.719229e-03 | 25 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | Glucagon signaling pathway | 3 | 1.860367e-03 | 25 |
| KEGG | KEGG:00030 | Pentose phosphate pathway | Pentose phosphate pathway | 2 | 9.415230e-03 | 25 |
| KEGG | KEGG:00640 | Propanoate metabolism | Propanoate metabolism | 2 | 1.003975e-02 | 25 |
| KEGG | KEGG:00051 | Fructose and mannose metabolism | Fructose and mannose metabolism | 2 | 1.134829e-02 | 25 |
| KEGG | KEGG:00270 | Cysteine and methionine metabolism | Cysteine and methionine metabolism | 2 | 2.465555e-02 | 25 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006090 | pyruvate metabolic process | "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] | 5 | 3.507164e-08 | 25 |
| GO:BP | GO:0019362 | pyridine nucleotide metabolic process | "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] | 5 | 1.358814e-07 | 25 |
| GO:BP | GO:0046496 | nicotinamide nucleotide metabolic process | "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] | 5 | 1.358814e-07 | 25 |
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 5 | 1.682783e-07 | 25 |
| GO:BP | GO:0019752 | carboxylic acid metabolic process | "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] | 6 | 4.951469e-06 | 25 |
| GO:BP | GO:0006096 | glycolytic process | "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] | 4 | 5.200915e-06 | 25 |
| GO:BP | GO:0046032 | ADP catabolic process | "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators] | 4 | 5.659598e-06 | 25 |
| GO:BP | GO:0043436 | oxoacid metabolic process | "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] | 6 | 5.737915e-06 | 25 |
| GO:BP | GO:0006082 | organic acid metabolic process | "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] | 6 | 5.969591e-06 | 25 |
| GO:BP | GO:0019364 | pyridine nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw] | 4 | 6.147932e-06 | 25 |
| GO:BP | GO:0009137 | purine nucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 6.403607e-06 | 25 |
| GO:BP | GO:0009181 | purine ribonucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 6.403607e-06 | 25 |
| GO:BP | GO:0072526 | pyridine-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 4 | 6.938763e-06 | 25 |
| GO:BP | GO:0009191 | ribonucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 7.218566e-06 | 25 |
| GO:BP | GO:0046031 | ADP metabolic process | "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators] | 4 | 7.506735e-06 | 25 |
| GO:BP | GO:0009134 | nucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 8.423096e-06 | 25 |
| GO:BP | GO:0009135 | purine nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 1.167885e-05 | 25 |
| GO:BP | GO:0009179 | purine ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 1.167885e-05 | 25 |
| GO:BP | GO:0009185 | ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 1.631309e-05 | 25 |
| GO:BP | GO:0009154 | purine ribonucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 1.793920e-05 | 25 |
| GO:BP | GO:0006163 | purine nucleotide metabolic process | "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 5 | 1.841552e-05 | 25 |
| GO:BP | GO:0009132 | nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 2.029255e-05 | 25 |
| GO:BP | GO:0009261 | ribonucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 2.220372e-05 | 25 |
| GO:BP | GO:0006195 | purine nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 2.355063e-05 | 25 |
| GO:BP | GO:0006091 | generation of precursor metabolites and energy | "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] | 5 | 3.127237e-05 | 25 |
| GO:BP | GO:0009117 | nucleotide metabolic process | "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] | 5 | 3.649815e-05 | 25 |
| GO:BP | GO:0072523 | purine-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 4 | 3.761429e-05 | 25 |
| GO:BP | GO:0009166 | nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] | 4 | 4.493562e-05 | 25 |
| GO:BP | GO:0016052 | carbohydrate catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] | 4 | 5.853108e-05 | 25 |
| GO:BP | GO:0072521 | purine-containing compound metabolic process | "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 5 | 7.086783e-05 | 25 |
| GO:BP | GO:1901292 | nucleoside phosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie] | 4 | 7.664428e-05 | 25 |
| GO:BP | GO:0032787 | monocarboxylic acid metabolic process | "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] | 5 | 1.110564e-04 | 25 |
| GO:BP | GO:0006753 | nucleoside phosphate metabolic process | "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] | 5 | 1.407998e-04 | 25 |
| GO:BP | GO:0055086 | nucleobase-containing small molecule metabolic process | "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] | 5 | 1.727064e-04 | 25 |
| GO:BP | GO:0046034 | ATP metabolic process | "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] | 4 | 1.804709e-04 | 25 |
| GO:BP | GO:0046434 | organophosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai] | 4 | 2.404545e-04 | 25 |
| GO:BP | GO:0009205 | purine ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 2.690525e-04 | 25 |
| GO:BP | GO:1901136 | carbohydrate derivative catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie] | 4 | 2.864942e-04 | 25 |
| GO:BP | GO:0009144 | purine nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 3.001198e-04 | 25 |
| GO:BP | GO:0009199 | ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 3.001198e-04 | 25 |
| GO:BP | GO:0044281 | small molecule metabolic process | "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] | 6 | 3.217643e-04 | 25 |
| GO:BP | GO:0009141 | nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 3.811445e-04 | 25 |
| GO:BP | GO:0009150 | purine ribonucleotide metabolic process | "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 9.958801e-04 | 25 |
| GO:BP | GO:0009259 | ribonucleotide metabolic process | "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 4 | 1.255651e-03 | 25 |
| GO:BP | GO:0019693 | ribose phosphate metabolic process | "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 4 | 1.366821e-03 | 25 |
| GO:BP | GO:0019637 | organophosphate metabolic process | "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] | 5 | 1.792821e-03 | 25 |
| GO:BP | GO:0030388 | fructose 1,6-bisphosphate metabolic process | "The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [ISBN:0198506732] | 2 | 2.179352e-03 | 25 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 4 | 5.330649e-03 | 25 |
| GO:BP | GO:0006000 | fructose metabolic process | "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732] | 2 | 5.505425e-03 | 25 |
| GO:BP | GO:0005975 | carbohydrate metabolic process | "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] | 4 | 6.435263e-03 | 25 |
| GO:BP | GO:0006089 | lactate metabolic process | "The chemical reactions and pathways involving lactate, the anion of lactic acid." [ISBN:0198547684] | 2 | 1.033880e-02 | 25 |
| GO:BP | GO:0019318 | hexose metabolic process | "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] | 3 | 2.136690e-02 | 25 |
| GO:BP | GO:0005996 | monosaccharide metabolic process | "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732] | 3 | 2.888483e-02 | 25 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004332 | fructose-bisphosphate aldolase activity | "Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate." [EC:4.1.2.13] | 2 | 0.000037 | 25 |
| GO:MF | GO:0004459 | L-lactate dehydrogenase activity | "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27, RHEA:23444] | 2 | 0.000185 | 25 |
| GO:MF | GO:0004457 | lactate dehydrogenase activity | "Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate." [GOC:ai, GOC:bf] | 2 | 0.000259 | 25 |
| GO:MF | GO:0016832 | aldehyde-lyase activity | "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [GOC:curators] | 2 | 0.000443 | 25 |
| GO:MF | GO:0016829 | lyase activity | "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-] | 3 | 0.004449 | 25 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 3 | 0.014568 | 25 |
| GO:MF | GO:0016830 | carbon-carbon lyase activity | "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] | 2 | 0.017512 | 25 |
| GO:MF | GO:0004333 | fumarate hydratase activity | "Catalysis of the reaction: (S)-malate = fumarate + H2O." [EC:4.2.1.2, RHEA:12460] | 1 | 0.049891 | 25 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 6 | 0.000137 | 25 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 6 | 0.000150 | 25 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 6 | 0.000150 | 25 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 6 | 0.000150 | 25 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 3 | 0.000624 | 25 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 3 | 0.002043 | 25 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 6 | 0.002066 | 25 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 6 | 0.006704 | 25 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 6 | 0.009287 | 25 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 3 | 0.010975 | 25 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 3 | 0.011488 | 25 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 3 | 0.011593 | 25 |
| GO:CC | GO:1904724 | tertiary granule lumen | "Any membrane-enclosed lumen that is part of a tertiary granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 2 | 0.016649 | 25 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 6 | 0.044795 | 25 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0090951 | Cerebellum; Purkinje cells - dendrites[≥Low] | Cerebellum; Purkinje cells - dendrites[≥Low] | 3 | 0.002553 | 25 |
| HPA | HPA:0090941 | Cerebellum; Purkinje cells - cytoplasm/membrane[≥Low] | Cerebellum; Purkinje cells - cytoplasm/membrane[≥Low] | 3 | 0.018078 | 25 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0009045 | Exercise-induced rhabdomyolysis | Rhabdomyolysis induced by exercise. | 2 | 0.006008 | 25 |
| HP | HP:0045040 | Abnormal circulating lactate dehydrogenase concentration | A deviation from the normal serum concentration/activity of lactate dehydrogenase (LDH), which catalyzes the reduction of pyruvate to form lactate. | 3 | 0.024417 | 25 |
| HP | HP:0008331 | Elevated creatine kinase after exercise | Elevated creatine kinase after exercise | 2 | 0.026393 | 25 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-70263 | Gluconeogenesis | Gluconeogenesis | 2 | 0.015320 | 25 |
| REAC | REAC:R-HSA-1428517 | Aerobic respiration and respiratory electron transport | Aerobic respiration and respiratory electron transport | 3 | 0.029166 | 25 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-23a-3p | hsa-mir-23a-3p | hsa-mir-23a-3p | 3 | 0.02422 | 25 |
Community 26
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-69183 | Processive synthesis on the lagging strand | Processive synthesis on the lagging strand | 6 | 4.577646e-16 | 26 |
| REAC | REAC:R-HSA-69186 | Lagging Strand Synthesis | Lagging Strand Synthesis | 6 | 3.545046e-15 | 26 |
| REAC | REAC:R-HSA-69190 | DNA strand elongation | DNA strand elongation | 6 | 8.288165e-14 | 26 |
| REAC | REAC:R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | Telomere C-strand (Lagging Strand) Synthesis | 6 | 1.230069e-13 | 26 |
| REAC | REAC:R-HSA-180786 | Extension of Telomeres | Extension of Telomeres | 6 | 1.647172e-12 | 26 |
| REAC | REAC:R-HSA-69166 | Removal of the Flap Intermediate | Removal of the Flap Intermediate | 5 | 2.012608e-12 | 26 |
| REAC | REAC:R-HSA-69109 | Leading Strand Synthesis | Leading Strand Synthesis | 5 | 2.012608e-12 | 26 |
| REAC | REAC:R-HSA-69091 | Polymerase switching | Polymerase switching | 5 | 2.012608e-12 | 26 |
| REAC | REAC:R-HSA-174411 | Polymerase switching on the C-strand of the telomere | Polymerase switching on the C-strand of the telomere | 5 | 6.606838e-11 | 26 |
| REAC | REAC:R-HSA-157579 | Telomere Maintenance | Telomere Maintenance | 6 | 2.070910e-10 | 26 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 6 | 3.515160e-10 | 26 |
| REAC | REAC:R-HSA-73886 | Chromosome Maintenance | Chromosome Maintenance | 6 | 7.858405e-10 | 26 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 6 | 2.090838e-09 | 26 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 6 | 5.009244e-09 | 26 |
| REAC | REAC:R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 4 | 5.530395e-09 | 26 |
| REAC | REAC:R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 4 | 5.530395e-09 | 26 |
| REAC | REAC:R-HSA-5358508 | Mismatch Repair | Mismatch Repair | 4 | 7.540350e-09 | 26 |
| REAC | REAC:R-HSA-174414 | Processive synthesis on the C-strand of the telomere | Processive synthesis on the C-strand of the telomere | 4 | 2.139881e-08 | 26 |
| REAC | REAC:R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | PCNA-Dependent Long Patch Base Excision Repair | 4 | 3.303267e-08 | 26 |
| REAC | REAC:R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | Gap-filling DNA repair synthesis and ligation in GG-NER | 4 | 6.977775e-08 | 26 |
| REAC | REAC:R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4 | 6.977775e-08 | 26 |
| REAC | REAC:R-HSA-73933 | Resolution of Abasic Sites (AP sites) | Resolution of Abasic Sites (AP sites) | 4 | 3.244012e-07 | 26 |
| REAC | REAC:R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | Gap-filling DNA repair synthesis and ligation in TC-NER | 4 | 2.863491e-06 | 26 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 6 | 3.384028e-06 | 26 |
| REAC | REAC:R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4 | 6.655715e-06 | 26 |
| REAC | REAC:R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | Global Genome Nucleotide Excision Repair (GG-NER) | 4 | 1.055191e-05 | 26 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 6 | 1.217599e-05 | 26 |
| REAC | REAC:R-HSA-73884 | Base Excision Repair | Base Excision Repair | 4 | 1.274500e-05 | 26 |
| REAC | REAC:R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | Removal of the Flap Intermediate from the C-strand | 3 | 1.375719e-05 | 26 |
| REAC | REAC:R-HSA-5696398 | Nucleotide Excision Repair | Nucleotide Excision Repair | 4 | 2.812709e-05 | 26 |
| REAC | REAC:R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | Recognition of DNA damage by PCNA-containing replication complex | 3 | 8.192013e-05 | 26 |
| REAC | REAC:R-HSA-5656169 | Termination of translesion DNA synthesis | Termination of translesion DNA synthesis | 3 | 1.000388e-04 | 26 |
| REAC | REAC:R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | 3 | 1.840612e-04 | 26 |
| REAC | REAC:R-HSA-5696400 | Dual Incision in GG-NER | Dual Incision in GG-NER | 3 | 2.146064e-04 | 26 |
| REAC | REAC:R-HSA-73893 | DNA Damage Bypass | DNA Damage Bypass | 3 | 3.477026e-04 | 26 |
| REAC | REAC:R-HSA-6782135 | Dual incision in TC-NER | Dual incision in TC-NER | 3 | 7.581170e-04 | 26 |
| REAC | REAC:R-HSA-5685942 | HDR through Homologous Recombination (HRR) | HDR through Homologous Recombination (HRR) | 3 | 1.095484e-03 | 26 |
| REAC | REAC:R-HSA-68952 | DNA replication initiation | DNA replication initiation | 2 | 1.560281e-03 | 26 |
| REAC | REAC:R-HSA-73894 | DNA Repair | DNA Repair | 4 | 2.528197e-03 | 26 |
| REAC | REAC:R-HSA-174430 | Telomere C-strand synthesis initiation | Telomere C-strand synthesis initiation | 2 | 4.341231e-03 | 26 |
| REAC | REAC:R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 2 | 5.063542e-03 | 26 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 3 | 7.236098e-03 | 26 |
| REAC | REAC:R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3 | 7.743939e-03 | 26 |
| REAC | REAC:R-HSA-5693538 | Homology Directed Repair | Homology Directed Repair | 3 | 8.829096e-03 | 26 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 3 | 1.042581e-02 | 26 |
| REAC | REAC:R-HSA-113510 | E2F mediated regulation of DNA replication | E2F mediated regulation of DNA replication | 2 | 1.404706e-02 | 26 |
| REAC | REAC:R-HSA-5693532 | DNA Double-Strand Break Repair | DNA Double-Strand Break Repair | 3 | 1.577067e-02 | 26 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 2 | 1.946931e-02 | 26 |
| REAC | REAC:R-HSA-68962 | Activation of the pre-replicative complex | Activation of the pre-replicative complex | 2 | 2.924456e-02 | 26 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03030 | DNA replication | DNA replication | 6 | 1.846754e-13 | 26 |
| KEGG | KEGG:03430 | Mismatch repair | Mismatch repair | 4 | 3.007510e-08 | 26 |
| KEGG | KEGG:03410 | Base excision repair | Base excision repair | 4 | 4.592362e-07 | 26 |
| KEGG | KEGG:03420 | Nucleotide excision repair | Nucleotide excision repair | 4 | 1.759721e-06 | 26 |
| KEGG | KEGG:03440 | Homologous recombination | Homologous recombination | 2 | 1.655099e-02 | 26 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030894 | replisome | "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] | 5 | 1.058956e-12 | 26 |
| GO:CC | GO:0043596 | nuclear replication fork | "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] | 5 | 1.865875e-11 | 26 |
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 5 | 4.291791e-10 | 26 |
| GO:CC | GO:0042575 | DNA polymerase complex | "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, PMID:12045093] | 4 | 1.335968e-09 | 26 |
| GO:CC | GO:0043601 | nuclear replisome | "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] | 4 | 2.016758e-09 | 26 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 5 | 1.414300e-07 | 26 |
| GO:CC | GO:0032993 | protein-DNA complex | "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] | 5 | 1.639476e-07 | 26 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 5 | 7.216183e-07 | 26 |
| GO:CC | GO:0043625 | delta DNA polymerase complex | "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614] | 2 | 6.768306e-05 | 26 |
| GO:CC | GO:0005658 | alpha DNA polymerase:primase complex | "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a small stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402, PMID:26975377] | 2 | 1.127915e-04 | 26 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 5 | 1.238669e-04 | 26 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 5 | 3.435637e-03 | 26 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 5 | 6.133790e-03 | 26 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 4 | 8.541786e-03 | 26 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 6 | 9.247745e-03 | 26 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 5 | 2.564275e-02 | 26 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 6 | 4.508711e-02 | 26 |
| GO:CC | GO:0043626 | PCNA complex | "A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735] | 1 | 4.998018e-02 | 26 |
| GO:CC | GO:0044796 | DNA polymerase processivity factor complex | "A protein complex which is capable of increasing the processivity of nucleotide polymerization by DNA polymerase as a part of DNA replication." [GOC:bhm, GOC:jl] | 1 | 4.998018e-02 | 26 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006261 | DNA-templated DNA replication | "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] | 6 | 1.577909e-10 | 26 |
| GO:BP | GO:0006271 | DNA strand elongation involved in DNA replication | "The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication." [GOC:mah, ISBN:071673706X, ISBN:0815316194] | 4 | 2.243627e-09 | 26 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 6 | 5.036174e-09 | 26 |
| GO:BP | GO:0022616 | DNA strand elongation | "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:isa_complete, GOC:mah] | 4 | 1.083753e-07 | 26 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 5 | 1.839252e-07 | 26 |
| GO:BP | GO:0000731 | DNA synthesis involved in DNA repair | "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855] | 4 | 2.226392e-07 | 26 |
| GO:BP | GO:0006287 | base-excision repair, gap-filling | "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131] | 3 | 4.191266e-06 | 26 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 6 | 1.049674e-05 | 26 |
| GO:BP | GO:0019985 | translesion synthesis | "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901] | 3 | 2.989917e-05 | 26 |
| GO:BP | GO:0006301 | postreplication repair | "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh] | 3 | 8.201980e-05 | 26 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 5 | 1.156290e-04 | 26 |
| GO:BP | GO:0033260 | nuclear DNA replication | "The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] | 3 | 1.223897e-04 | 26 |
| GO:BP | GO:0044786 | cell cycle DNA replication | "The DNA-dependent DNA replication that takes place as part of the cell cycle." [GOC:mtg_cell_cycle] | 3 | 1.628486e-04 | 26 |
| GO:BP | GO:0006284 | base-excision repair | "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] | 3 | 1.741915e-04 | 26 |
| GO:BP | GO:0006272 | leading strand elongation | "The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork." [GOC:mah, ISBN:071673706X, ISBN:0815316194] | 2 | 3.634558e-04 | 26 |
| GO:BP | GO:0006273 | lagging strand elongation | "The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork." [GOC:mah, ISBN:071673706X, ISBN:0815316194] | 2 | 3.634558e-04 | 26 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 5 | 7.676497e-04 | 26 |
| GO:BP | GO:0006269 | DNA replication, synthesis of primer | "The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer." [PMID:11395402, PMID:38203225, PMID:38492718] | 2 | 1.695267e-03 | 26 |
| GO:BP | GO:1902969 | mitotic DNA replication | "Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] | 2 | 8.224756e-03 | 26 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 5 | 2.469572e-02 | 26 |
| GO:BP | GO:0006298 | mismatch repair | "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] | 2 | 2.993912e-02 | 26 |
| GO:BP | GO:0006270 | DNA replication initiation | "The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641] | 2 | 4.017501e-02 | 26 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1107 | DNA synthesome core complex | DNA synthesome core complex | 4 | 9.717787e-10 | 26 |
| CORUM | CORUM:1098 | DNA synthesome complex (13 subunits) | DNA synthesome complex (13 subunits) | 4 | 1.619631e-09 | 26 |
| CORUM | CORUM:1108 | DNA synthesome complex (15 subunits) | DNA synthesome complex (15 subunits) | 4 | 5.514458e-09 | 26 |
| CORUM | CORUM:1111 | DNA synthesome complex (17 subunits) | DNA synthesome complex (17 subunits) | 4 | 7.720242e-09 | 26 |
| CORUM | CORUM:1099 | DNA synthesome complex (17 subunits) | DNA synthesome complex (17 subunits) | 4 | 7.720242e-09 | 26 |
| CORUM | CORUM:297 | PCNA-DNA polymerase delta complex | PCNA-DNA polymerase delta complex | 2 | 2.642027e-04 | 26 |
| CORUM | CORUM:1100 | DNA polymerase alpha-primase complex | DNA polymerase alpha-primase complex | 2 | 2.642027e-04 | 26 |
| CORUM | CORUM:1003 | RC complex (Replication competent complex) | RC complex (Replication competent complex) | 2 | 1.231001e-03 | 26 |
| CORUM | CORUM:1004 | RC complex during S-phase of cell cycle | RC complex during S-phase of cell cycle | 2 | 1.582091e-03 | 26 |
| CORUM | CORUM:1005 | RC complex during G2/M-phase of cell cycle | RC complex during G2/M-phase of cell cycle | 2 | 1.976833e-03 | 26 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP466 | DNA replication | DNA replication | 5 | 1.307607e-09 | 26 |
| WP | WP:WP531 | DNA mismatch repair | DNA mismatch repair | 4 | 5.953984e-08 | 26 |
| WP | WP:WP4752 | Base excision repair | Base excision repair | 4 | 2.112565e-07 | 26 |
| WP | WP:WP4753 | Nucleotide excision repair | Nucleotide excision repair | 4 | 8.267547e-07 | 26 |
| WP | WP:WP5114 | Nucleotide excision repair in xeroderma pigmentosum | Nucleotide excision repair in xeroderma pigmentosum | 4 | 7.664542e-06 | 26 |
| WP | WP:WP4022 | Pyrimidine metabolism | Pyrimidine metabolism | 4 | 1.282914e-05 | 26 |
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 4 | 5.245776e-05 | 26 |
| WP | WP:WP186 | Homologous recombination | Homologous recombination | 2 | 3.346208e-03 | 26 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0034061 | DNA polymerase activity | "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)." [RHEA:22508] | 3 | 0.000024 | 26 |
| GO:MF | GO:0140097 | catalytic activity, acting on DNA | "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] | 4 | 0.000066 | 26 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 6 | 0.000656 | 26 |
| GO:MF | GO:0016779 | nucleotidyltransferase activity | "Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor)." [EC:2.7.7.-] | 3 | 0.001485 | 26 |
| GO:MF | GO:0140640 | catalytic activity, acting on a nucleic acid | "Catalytic activity that acts to modify a nucleic acid." [GOC:pg] | 4 | 0.002449 | 26 |
| GO:MF | GO:0003887 | DNA-directed DNA polymerase activity | "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time." [EC:2.7.7.7, GOC:vw] | 2 | 0.003391 | 26 |
| GO:MF | GO:0003684 | damaged DNA binding | "Binding to damaged DNA." [GOC:jl] | 2 | 0.034776 | 26 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 5 | 0.002333 | 26 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 5 | 0.006312 | 26 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 5 | 0.008635 | 26 |
| HPA | HPA:0030073 | Appendix; lymphoid tissue[High] | Appendix; lymphoid tissue[High] | 4 | 0.028518 | 26 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 5 | 0.036629 | 26 |
| HPA | HPA:0320892 | Nasopharynx; goblet cells[≥Medium] | Nasopharynx; goblet cells[≥Medium] | 3 | 0.049220 | 26 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M08875_1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | 5 | 0.032641 | 26 |
Community 27
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP254 | Apoptosis | Apoptosis | 2 | 0.019006 | 27 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0160074 | non-canonical inflammasome complex | "An inflammasome complex containing CASP4, known as caspase-11 (Casp11) in mouse, which assembles upon cytosolic lipopolysaccharide-binding and directly activates Gasdermin-D (GSDMD)." [PMID:33187725] | 1 | 0.024944 | 27 |
Community 28
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005643 | nuclear pore | "A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] | 3 | 0.000179 | 28 |
| GO:CC | GO:0005635 | nuclear envelope | "The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport." [ISBN:0198547684, PMID:16164970] | 3 | 0.027324 | 28 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | Nucleocytoplasmic transport | 3 | 0.000965 | 28 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | Postmitotic nuclear pore complex (NPC) reformation | 2 | 0.004624 | 28 |
| REAC | REAC:R-HSA-177243 | Interactions of Rev with host cellular proteins | Interactions of Rev with host cellular proteins | 2 | 0.009387 | 28 |
| REAC | REAC:R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | Nuclear Envelope (NE) Reassembly | 2 | 0.040235 | 28 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0031267 | small GTPase binding | "Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782] | 3 | 0.005472 | 28 |
| GO:MF | GO:0051020 | GTPase binding | "Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai] | 3 | 0.007520 | 28 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0090963 | Cerebellum; Purkinje cells - nucleus[High] | Cerebellum; Purkinje cells - nucleus[High] | 2 | 0.022583 | 28 |
| HPA | HPA:0090962 | Cerebellum; Purkinje cells - nucleus[≥Medium] | Cerebellum; Purkinje cells - nucleus[≥Medium] | 2 | 0.045042 | 28 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 3 | 0.026594 | 28 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] | 3 | 0.030792 | 28 |
| GO:BP | GO:0051169 | nuclear transport | "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] | 3 | 0.030792 | 28 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4657 | 22q11 2 copy number variation syndrome | 22q11 2 copy number variation syndrome | 2 | 0.039259 | 28 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6170 | Angiogenin-PRI complex | Angiogenin-PRI complex | 1 | 0.049932 | 28 |
| CORUM | CORUM:7543 | KPNB1-SMN-SPN complex | KPNB1-SMN-SPN complex | 1 | 0.049932 | 28 |
Community 29
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 5 | 3.987462e-08 | 29 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 5 | 9.987266e-08 | 29 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 5 | 5.249292e-07 | 29 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | Progesterone-mediated oocyte maturation | 4 | 4.783737e-06 | 29 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | Ubiquitin mediated proteolysis | 3 | 2.104552e-03 | 29 |
| KEGG | KEGG:04115 | p53 signaling pathway | p53 signaling pathway | 2 | 3.617303e-02 | 29 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP179 | Cell cycle | Cell cycle | 5 | 4.287267e-08 | 29 |
| WP | WP:WP3391 | Senescence associated secretory phenotype SASP | Senescence associated secretory phenotype SASP | 3 | 1.925641e-03 | 29 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4 | 9.548287e-08 | 29 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 4 | 1.196340e-07 | 29 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 4 | 1.759547e-06 | 29 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 5 | 2.396594e-06 | 29 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 4 | 4.510735e-06 | 29 |
| REAC | REAC:R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 3 | 1.016448e-05 | 29 |
| REAC | REAC:R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 3 | 1.016448e-05 | 29 |
| REAC | REAC:R-HSA-176412 | Phosphorylation of the APC/C | Phosphorylation of the APC/C | 3 | 1.016448e-05 | 29 |
| REAC | REAC:R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | Inactivation of APC/C via direct inhibition of the APC/C complex | 3 | 1.185694e-05 | 29 |
| REAC | REAC:R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | 3 | 1.185694e-05 | 29 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 4 | 1.368543e-05 | 29 |
| REAC | REAC:R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | APC/C:Cdc20 mediated degradation of Cyclin B | 3 | 1.803655e-05 | 29 |
| REAC | REAC:R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | APC-Cdc20 mediated degradation of Nek2A | 3 | 2.316315e-05 | 29 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 4 | 4.440303e-05 | 29 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 5 | 6.027548e-05 | 29 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 4 | 7.908592e-05 | 29 |
| REAC | REAC:R-HSA-8853884 | Transcriptional Regulation by VENTX | Transcriptional Regulation by VENTX | 3 | 8.127402e-05 | 29 |
| REAC | REAC:R-HSA-2559583 | Cellular Senescence | Cellular Senescence | 4 | 9.166944e-05 | 29 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 5 | 1.750451e-04 | 29 |
| REAC | REAC:R-HSA-68882 | Mitotic Anaphase | Mitotic Anaphase | 4 | 1.752638e-04 | 29 |
| REAC | REAC:R-HSA-2555396 | Mitotic Metaphase and Anaphase | Mitotic Metaphase and Anaphase | 4 | 1.783665e-04 | 29 |
| REAC | REAC:R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | Autodegradation of Cdh1 by Cdh1:APC/C | 3 | 3.692572e-04 | 29 |
| REAC | REAC:R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | APC/C:Cdc20 mediated degradation of Securin | 3 | 4.439219e-04 | 29 |
| REAC | REAC:R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3 | 5.505481e-04 | 29 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 3 | 5.737321e-04 | 29 |
| REAC | REAC:R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 3 | 5.737321e-04 | 29 |
| REAC | REAC:R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | APC/C:Cdc20 mediated degradation of mitotic proteins | 3 | 6.220276e-04 | 29 |
| REAC | REAC:R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3 | 6.471563e-04 | 29 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 3 | 7.544104e-04 | 29 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 3 | 9.693693e-04 | 29 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 3 | 9.693693e-04 | 29 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 4 | 1.776690e-03 | 29 |
| REAC | REAC:R-HSA-69618 | Mitotic Spindle Checkpoint | Mitotic Spindle Checkpoint | 3 | 1.849148e-03 | 29 |
| REAC | REAC:R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | Senescence-Associated Secretory Phenotype (SASP) | 3 | 1.953262e-03 | 29 |
| REAC | REAC:R-HSA-68867 | Assembly of the pre-replicative complex | Assembly of the pre-replicative complex | 3 | 4.096412e-03 | 29 |
| REAC | REAC:R-HSA-69002 | DNA Replication Pre-Initiation | DNA Replication Pre-Initiation | 3 | 5.750502e-03 | 29 |
| REAC | REAC:R-HSA-2467813 | Separation of Sister Chromatids | Separation of Sister Chromatids | 3 | 9.495725e-03 | 29 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 4 | 2.542044e-02 | 29 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 4 | 2.723066e-02 | 29 |
| REAC | REAC:R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | Antigen processing: Ubiquitination & Proteasome degradation | 3 | 4.132449e-02 | 29 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051321 | meiotic cell cycle | "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] | 5 | 4.316561e-07 | 29 |
| GO:BP | GO:0141198 | protein branched polyubiquitination | "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at various positions of the ubiquitin monomers, forming branched linkages, such as K11/K48- or K11/K63-linked chains." [PMID:29033132, PMID:29378950, PMID:31998699, PMID:37325469] | 3 | 3.480548e-06 | 29 |
| GO:BP | GO:0031145 | anaphase-promoting complex-dependent catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442] | 3 | 1.176572e-05 | 29 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 5 | 2.347291e-05 | 29 |
| GO:BP | GO:0070979 | protein K11-linked ubiquitination | "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135] | 3 | 4.670411e-05 | 29 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 5 | 1.078947e-04 | 29 |
| GO:BP | GO:0098813 | nuclear chromosome segregation | "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos] | 4 | 2.143412e-04 | 29 |
| GO:BP | GO:0051445 | regulation of meiotic cell cycle | "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 3 | 2.555834e-04 | 29 |
| GO:BP | GO:0019953 | sexual reproduction | "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] | 5 | 3.405188e-04 | 29 |
| GO:BP | GO:0007059 | chromosome segregation | "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] | 4 | 6.549997e-04 | 29 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 4 | 6.611534e-04 | 29 |
| GO:BP | GO:0070936 | protein K48-linked ubiquitination | "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404] | 3 | 7.981323e-04 | 29 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 1.153738e-03 | 29 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 4 | 1.576229e-03 | 29 |
| GO:BP | GO:0022414 | reproductive process | "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] | 5 | 2.064332e-03 | 29 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 5 | 2.442869e-03 | 29 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 4 | 6.031093e-03 | 29 |
| GO:BP | GO:2000241 | regulation of reproductive process | "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] | 3 | 6.938197e-03 | 29 |
| GO:BP | GO:0000209 | protein polyubiquitination | "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [PMID:26906419] | 3 | 1.818047e-02 | 29 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 4 | 2.703565e-02 | 29 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005680 | anaphase-promoting complex | "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] | 3 | 0.000002 | 29 |
| GO:CC | GO:0000152 | nuclear ubiquitin ligase complex | "A ubiquitin ligase complex found in the nucleus." [GOC:mah] | 3 | 0.000022 | 29 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 5 | 0.000026 | 29 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 5 | 0.000736 | 29 |
| GO:CC | GO:0031461 | cullin-RING ubiquitin ligase complex | "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] | 3 | 0.001357 | 29 |
| GO:CC | GO:0000151 | ubiquitin ligase complex | "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] | 3 | 0.006652 | 29 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 2 | 0.020425 | 29 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:96 | Anaphase-promoting complex | Anaphase-promoting complex | 2 | 0.000827 | 29 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 2 | 0.011091 | 29 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 2 | 0.026490 | 29 |
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 2 | 0.026490 | 29 |
Community 30
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4211 | Transcriptional cascade regulating adipogenesis | Transcriptional cascade regulating adipogenesis | 2 | 0.001030 | 30 |
| WP | WP:WP5102 | Familial partial lipodystrophy | Familial partial lipodystrophy | 2 | 0.005732 | 30 |
| WP | WP:WP4149 | White fat cell differentiation | White fat cell differentiation | 2 | 0.006534 | 30 |
| WP | WP:WP3527 | Pre implantation embryo | Pre implantation embryo | 2 | 0.021688 | 30 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0035162 | embryonic hemopoiesis | "The stages of blood cell formation that take place within the embryo." [GOC:bf] | 2 | 0.009889 | 30 |
| GO:BP | GO:2000352 | negative regulation of endothelial cell apoptotic process | "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] | 2 | 0.017759 | 30 |
| GO:BP | GO:0001709 | cell fate determination | "The cellular developmental process involved in cell fate commitment that occurs after cell fate specification, in which a cell is irreversibly committed to a cellular developmental fate which is heritable on cell division." [ISBN:0878932437] | 2 | 0.035402 | 30 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0001223 | transcription coactivator binding | "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] | 2 | 0.01063 | 30 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03083 | Polycomb repressive complex | Polycomb repressive complex | 2 | 0.014295 | 30 |
Community 31
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 5 | 0.001732 | 31 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 5 | 0.001859 | 31 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 5 | 0.001864 | 31 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 5 | 0.001864 | 31 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 5 | 0.016573 | 31 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 5 | 0.044193 | 31 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 3 | 0.006767 | 31 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 3 | 0.008027 | 31 |
| GO:MF | GO:0016894 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters | "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah] | 1 | 0.049992 | 31 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0003568 | Decreased glucosephosphate isomerase level | A decreased level of glucose-6-phosphate isomerase. | 1 | 0.049962 | 31 |
Community 32
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5199 | Kinase maturation complex 1 | Kinase maturation complex 1 | 3 | 0.000005 | 32 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2 | 0.002551 | 32 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 3 | 0.012845 | 32 |
Community 33
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9843745 | Adipogenesis | Adipogenesis | 3 | 0.000619 | 33 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 4 | 0.002221 | 33 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 3 | 0.007106 | 33 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 4 | 0.009176 | 33 |
| GO:CC | GO:1990647 | C/EBP complex | "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, PMID:8657121] | 1 | 0.049885 | 33 |
| GO:CC | GO:0097130 | cyclin D3-CDK4 complex | "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 1 | 0.049885 | 33 |
| GO:CC | GO:0097128 | cyclin D1-CDK4 complex | "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 1 | 0.049885 | 33 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0070102 | interleukin-6-mediated signaling pathway | "The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling] | 2 | 0.002766 | 33 |
| GO:BP | GO:0071354 | cellular response to interleukin-6 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] | 2 | 0.008959 | 33 |
| GO:BP | GO:0070741 | response to interleukin-6 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] | 2 | 0.012026 | 33 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 3 | 0.005021 | 33 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 3 | 0.013808 | 33 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 3 | 0.025458 | 33 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 2 | 0.011694 | 33 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 2 | 0.011694 | 33 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 3 | 0.011802 | 33 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | AGE-RAGE signaling pathway in diabetic complications | 2 | 0.020272 | 33 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 2 | 0.049925 | 33 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-616-3p | hsa-mir-616-3p | hsa-mir-616-3p | 2 | 0.018384 | 33 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4879 | Overlap between signal transduction pathways contributing to LMNA laminopathies | Overlap between signal transduction pathways contributing to LMNA laminopathies | 2 | 0.020944 | 33 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 2 | 0.035352 | 33 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 2 | 0.049995 | 33 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3197 | SMAD4-SNO-SKI complex | SMAD4-SNO-SKI complex | 1 | 0.049932 | 33 |
| CORUM | CORUM:3200 | SMAD4-SKI complex | SMAD4-SKI complex | 1 | 0.049932 | 33 |
Community 34
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004013 | adenosylhomocysteinase activity | "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [RHEA:21708] | 1 | 0.049891 | 34 |
| GO:MF | GO:0046508 | hydrolase activity, acting on carbon-sulfur bonds | "Catalysis of the hydrolysis of any carbon-sulfur bond, C-S." [GOC:jl] | 1 | 0.049891 | 34 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5578997 | Defective AHCY causes HMAHCHD | Defective AHCY causes HMAHCHD | 1 | 0.049932 | 34 |
Community 35
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070603 | SWI/SNF superfamily-type complex | "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938] | 2 | 0.010048 | 35 |
| GO:CC | GO:1904949 | ATPase complex | "A protein complex which is capable of ATPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181] | 2 | 0.018272 | 35 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 3 | 0.011834 | 35 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 3 | 0.012343 | 35 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 3 | 0.016533 | 35 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 3 | 0.016743 | 35 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 3 | 0.017313 | 35 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 3 | 0.019640 | 35 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 3 | 0.020033 | 35 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 3 | 0.022422 | 35 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 3 | 0.023552 | 35 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 3 | 0.027167 | 35 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 3 | 0.030186 | 35 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 3 | 0.031240 | 35 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 3 | 0.031669 | 35 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 3 | 0.031884 | 35 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 3 | 0.031993 | 35 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 3 | 0.040697 | 35 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 3 | 0.048671 | 35 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:2000779 | regulation of double-strand break repair | "Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF] | 2 | 0.023924 | 35 |
Community 36
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0320853 | Nasopharynx; ciliated cells (cell body)[High] | Nasopharynx; ciliated cells (cell body)[High] | 3 | 0.001465 | 36 |
| HPA | HPA:0060852 | Bronchus; ciliated cells (cell body)[≥Medium] | Bronchus; ciliated cells (cell body)[≥Medium] | 3 | 0.031134 | 36 |
| HPA | HPA:0320852 | Nasopharynx; ciliated cells (cell body)[≥Medium] | Nasopharynx; ciliated cells (cell body)[≥Medium] | 3 | 0.032978 | 36 |
| HPA | HPA:0320893 | Nasopharynx; goblet cells[High] | Nasopharynx; goblet cells[High] | 2 | 0.033601 | 36 |
| HPA | HPA:0471452 | Skin 2; hair follicles[≥Medium] | Skin 2; hair follicles[≥Medium] | 2 | 0.038223 | 36 |
| HPA | HPA:0210851 | Fallopian tube; ciliated cells (cell body)[≥Low] | Fallopian tube; ciliated cells (cell body)[≥Low] | 3 | 0.041594 | 36 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1902562 | H4 histone acetyltransferase complex | "A protein complex which is capable of H4 histone acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:23775086] | 2 | 0.003043 | 36 |
| GO:CC | GO:0000123 | histone acetyltransferase complex | "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] | 2 | 0.014067 | 36 |
| GO:CC | GO:0031248 | protein acetyltransferase complex | "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf] | 2 | 0.017299 | 36 |
| GO:CC | GO:1902493 | acetyltransferase complex | "A protein complex which is capable of acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 2 | 0.017641 | 36 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | Epigenetic regulation by WDR5-containing histone modifying complexes | 2 | 0.01371 | 36 |
| REAC | REAC:R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | Formation of WDR5-containing histone-modifying complexes | 2 | 0.01371 | 36 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003712 | transcription coregulator activity | "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] | 3 | 0.014063 | 36 |
| GO:MF | GO:0060001 | minus-end directed microfilament motor activity | "A motor activity that generates movement along a microfilament towards the minus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers." [GOC:dph, PMID:10519557] | 1 | 0.049891 | 36 |
Community 37
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9845576 | Glycosphingolipid transport | Glycosphingolipid transport | 2 | 0.000470 | 37 |
| REAC | REAC:R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | Synthesis of PIPs at the plasma membrane | 2 | 0.023005 | 37 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 4 | 0.012356 | 37 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0098588 | bounding membrane of organelle | "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] | 4 | 0.014700 | 37 |
| GO:CC | GO:0000139 | Golgi membrane | "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] | 3 | 0.016106 | 37 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0005525 | GTP binding | "Binding to GTP, guanosine triphosphate." [GOC:ai] | 3 | 0.027406 | 37 |
| GO:MF | GO:0019001 | guanyl nucleotide binding | "Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732] | 3 | 0.032628 | 37 |
| GO:MF | GO:0032561 | guanyl ribonucleotide binding | "Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 3 | 0.032628 | 37 |
Community 38
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0131333 | Colon; mucosal lymphoid cells[High] | Colon; mucosal lymphoid cells[High] | 3 | 0.000806 | 38 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 3 | 0.001178 | 38 |
| HPA | HPA:0481352 | Small intestine; paneth cells[≥Medium] | Small intestine; paneth cells[≥Medium] | 3 | 0.002454 | 38 |
| HPA | HPA:0481351 | Small intestine; paneth cells[≥Low] | Small intestine; paneth cells[≥Low] | 3 | 0.003734 | 38 |
| HPA | HPA:0030431 | Appendix; germinal center cells[≥Low] | Appendix; germinal center cells[≥Low] | 3 | 0.004966 | 38 |
| HPA | HPA:0150892 | Duodenum; goblet cells[≥Medium] | Duodenum; goblet cells[≥Medium] | 3 | 0.007966 | 38 |
| HPA | HPA:0480892 | Small intestine; goblet cells[≥Medium] | Small intestine; goblet cells[≥Medium] | 3 | 0.008400 | 38 |
| HPA | HPA:0400892 | Rectum; goblet cells[≥Medium] | Rectum; goblet cells[≥Medium] | 3 | 0.008548 | 38 |
| HPA | HPA:0131332 | Colon; mucosal lymphoid cells[≥Medium] | Colon; mucosal lymphoid cells[≥Medium] | 3 | 0.010374 | 38 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 3 | 0.012252 | 38 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 3 | 0.013419 | 38 |
| HPA | HPA:0150891 | Duodenum; goblet cells[≥Low] | Duodenum; goblet cells[≥Low] | 3 | 0.013926 | 38 |
| HPA | HPA:0401292 | Rectum; endocrine cells[≥Medium] | Rectum; endocrine cells[≥Medium] | 3 | 0.013926 | 38 |
| HPA | HPA:0400891 | Rectum; goblet cells[≥Low] | Rectum; goblet cells[≥Low] | 3 | 0.014552 | 38 |
| HPA | HPA:0480891 | Small intestine; goblet cells[≥Low] | Small intestine; goblet cells[≥Low] | 3 | 0.014552 | 38 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 3 | 0.016423 | 38 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 3 | 0.018078 | 38 |
| HPA | HPA:0151292 | Duodenum; endocrine cells[≥Medium] | Duodenum; endocrine cells[≥Medium] | 3 | 0.018945 | 38 |
| HPA | HPA:0401291 | Rectum; endocrine cells[≥Low] | Rectum; endocrine cells[≥Low] | 3 | 0.019198 | 38 |
| HPA | HPA:0481292 | Small intestine; endocrine cells[≥Medium] | Small intestine; endocrine cells[≥Medium] | 3 | 0.020363 | 38 |
| HPA | HPA:0151291 | Duodenum; endocrine cells[≥Low] | Duodenum; endocrine cells[≥Low] | 3 | 0.025031 | 38 |
| HPA | HPA:0481291 | Small intestine; endocrine cells[≥Low] | Small intestine; endocrine cells[≥Low] | 3 | 0.025183 | 38 |
| HPA | HPA:0131301 | Colon; enterocytes[≥Low] | Colon; enterocytes[≥Low] | 3 | 0.027048 | 38 |
| HPA | HPA:0131331 | Colon; mucosal lymphoid cells[≥Low] | Colon; mucosal lymphoid cells[≥Low] | 3 | 0.027851 | 38 |
| HPA | HPA:0401301 | Rectum; enterocytes[≥Low] | Rectum; enterocytes[≥Low] | 3 | 0.028340 | 38 |
| HPA | HPA:0151301 | Duodenum; enterocytes[≥Low] | Duodenum; enterocytes[≥Low] | 3 | 0.032820 | 38 |
| HPA | HPA:0401331 | Rectum; mucosal lymphoid cells[≥Low] | Rectum; mucosal lymphoid cells[≥Low] | 3 | 0.033732 | 38 |
| HPA | HPA:0481301 | Small intestine; enterocytes[≥Low] | Small intestine; enterocytes[≥Low] | 3 | 0.038943 | 38 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0140534 | endoplasmic reticulum protein-containing complex | "A protein complex that is part of an endoplasmic reticulum." [GOC:pg] | 2 | 0.022382 | 38 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0003642 | Type I transferrin isoform profile | Abnormal transferrin isoform profile consistent with a type I congenital disorder of glycosylation. In the traditional nomenclature for congenital disorders of glycosylation, absence of entire glycans was designated type I, and loss of one or more monosaccharides as type II. | 2 | 0.038269 | 38 |
Community 39
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0075522 | IRES-dependent viral translational initiation | "Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation." [GOC:bf, GOC:jl, PMID:19632368, VZ:867] | 2 | 0.000995 | 39 |
| GO:BP | GO:0019081 | viral translation | "A process by which viral mRNA is translated into viral protein, using the host cellular machinery." [GOC:bf, GOC:jl, ISBN:0781702534] | 2 | 0.005872 | 39 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 4 | 0.049486 | 39 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | Negative regulators of DDX58/IFIH1 signaling | 2 | 0.009955 | 39 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-1255b-5p | hsa-mir-1255b-5p | hsa-mir-1255b-5p | 2 | 0.044599 | 39 |
Community 40
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730] | 3 | 0.000133 | 40 |
| GO:CC | GO:0034663 | endoplasmic reticulum chaperone complex | "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] | 2 | 0.000186 | 40 |
| GO:CC | GO:0005788 | endoplasmic reticulum lumen | "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] | 3 | 0.001528 | 40 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 2 | 0.021616 | 40 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 2 | 0.021616 | 40 |
| GO:CC | GO:0140534 | endoplasmic reticulum protein-containing complex | "A protein complex that is part of an endoplasmic reticulum." [GOC:pg] | 2 | 0.022382 | 40 |
| GO:CC | GO:0016222 | procollagen-proline 4-dioxygenase complex | "A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase." [PMID:14500733, PMID:7753822] | 1 | 0.049885 | 40 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003756 | protein disulfide isomerase activity | "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function] | 2 | 0.001263 | 40 |
| GO:MF | GO:0016864 | intramolecular oxidoreductase activity, transposing S-S bonds | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4.-, GOC:mah] | 2 | 0.001263 | 40 |
| GO:MF | GO:0015035 | protein-disulfide reductase activity | "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385] | 2 | 0.004139 | 40 |
| GO:MF | GO:0015036 | disulfide oxidoreductase activity | "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [GOC:curators] | 2 | 0.005752 | 40 |
| GO:MF | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors | "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.8.-.-, GOC:ai] | 2 | 0.010941 | 40 |
| GO:MF | GO:0016860 | intramolecular oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators] | 2 | 0.011345 | 40 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0130653 | Colon; fibroblasts[High] | Colon; fibroblasts[High] | 2 | 0.004826 | 40 |
| HPA | HPA:0400653 | Rectum; fibroblasts[High] | Rectum; fibroblasts[High] | 2 | 0.005904 | 40 |
| HPA | HPA:0130652 | Colon; fibroblasts[≥Medium] | Colon; fibroblasts[≥Medium] | 2 | 0.013756 | 40 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 3 | 0.015576 | 40 |
| HPA | HPA:0151343 | Duodenum; glands of Brunner[High] | Duodenum; glands of Brunner[High] | 2 | 0.016150 | 40 |
| HPA | HPA:0130651 | Colon; fibroblasts[≥Low] | Colon; fibroblasts[≥Low] | 2 | 0.016778 | 40 |
| HPA | HPA:0400652 | Rectum; fibroblasts[≥Medium] | Rectum; fibroblasts[≥Medium] | 2 | 0.017418 | 40 |
| HPA | HPA:0400651 | Rectum; fibroblasts[≥Low] | Rectum; fibroblasts[≥Low] | 2 | 0.022231 | 40 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 3 | 0.027167 | 40 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 3 | 0.031669 | 40 |
| HPA | HPA:0151353 | Duodenum; paneth cells[High] | Duodenum; paneth cells[High] | 2 | 0.041634 | 40 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 2 | 0.046756 | 40 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4786 | Type I collagen synthesis in the context of osteogenesis imperfecta | Type I collagen synthesis in the context of osteogenesis imperfecta | 2 | 0.006954 | 40 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | Collagen biosynthesis and modifying enzymes | 2 | 0.036849 | 40 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 3 | 0.043825 | 40 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0000703 | Dentinogenesis imperfecta | Developmental dysplasia of dentin. | 2 | 0.045712 | 40 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:472 | Prolyl 4-hydroxylase (alpha(I)-type) | Prolyl 4-hydroxylase (alpha(I)-type) | 1 | 0.049988 | 40 |
Community 41
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 3 | 0.007562 | 41 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 4 | 0.021454 | 41 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051693 | actin filament capping | "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] | 2 | 0.014081 | 41 |
| GO:BP | GO:0030835 | negative regulation of actin filament depolymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah] | 2 | 0.017074 | 41 |
| GO:BP | GO:0030834 | regulation of actin filament depolymerization | "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] | 2 | 0.024857 | 41 |
| GO:BP | GO:0030042 | actin filament depolymerization | "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] | 2 | 0.029808 | 41 |
| GO:BP | GO:0030837 | negative regulation of actin filament polymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] | 2 | 0.029808 | 41 |
| GO:BP | GO:0032272 | negative regulation of protein polymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 2 | 0.046050 | 41 |
| GO:BP | GO:1901880 | negative regulation of protein depolymerization | "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] | 2 | 0.047344 | 41 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 2 | 0.014777 | 41 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M04326_1 | Factor: GSC; motif: NYTAATCCNN; match class: 1 | Factor: GSC; motif: NYTAATCCNN; match class: 1 | 2 | 0.034367 | 41 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:756 | Prune-Gelsolin complex | Prune-Gelsolin complex | 1 | 0.049932 | 41 |
Community 42
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0032868 | response to insulin | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] | 3 | 0.001047 | 42 |
| GO:BP | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, ISBN:0781735149] | 2 | 0.001567 | 42 |
| GO:BP | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | "An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GOC:phg, PMID:12488490, PMID:15466916] | 2 | 0.001567 | 42 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] | 3 | 0.001666 | 42 |
| GO:BP | GO:0090330 | regulation of platelet aggregation | "Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:dph, GOC:tb] | 2 | 0.002753 | 42 |
| GO:BP | GO:0002431 | Fc receptor mediated stimulatory signaling pathway | "The series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GO_REF:0000022, GOC:add, ISBN:0781735149] | 2 | 0.003363 | 42 |
| GO:BP | GO:0038094 | Fc-gamma receptor signaling pathway | "The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:11244038] | 2 | 0.003803 | 42 |
| GO:BP | GO:0034110 | regulation of homotypic cell-cell adhesion | "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] | 2 | 0.004271 | 42 |
| GO:BP | GO:0043434 | response to peptide hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] | 3 | 0.004551 | 42 |
| GO:BP | GO:0043407 | negative regulation of MAP kinase activity | "Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] | 2 | 0.005287 | 42 |
| GO:BP | GO:0010543 | regulation of platelet activation | "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] | 2 | 0.009336 | 42 |
| GO:BP | GO:0038093 | Fc receptor signaling pathway | "The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, Wikipedia:Fc_receptor] | 2 | 0.011198 | 42 |
| GO:BP | GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] | 3 | 0.013324 | 42 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] | 3 | 0.013905 | 42 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 3 | 0.014369 | 42 |
| GO:BP | GO:0071901 | negative regulation of protein serine/threonine kinase activity | "Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:BHF, GOC:mah] | 2 | 0.017307 | 42 |
| GO:BP | GO:0070527 | platelet aggregation | "The adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF, GOC:vk] | 2 | 0.019295 | 42 |
| GO:BP | GO:0034109 | homotypic cell-cell adhesion | "The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add] | 2 | 0.034845 | 42 |
| GO:BP | GO:0042100 | B cell proliferation | "The expansion of a B cell population by cell division. Follows B cell activation." [GOC:jl] | 2 | 0.038357 | 42 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 3 | 0.040008 | 42 |
| GO:BP | GO:0043405 | regulation of MAP kinase activity | "Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] | 2 | 0.044324 | 42 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194] | 3 | 0.048948 | 42 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04930 | Type II diabetes mellitus | Type II diabetes mellitus | 2 | 0.004257 | 42 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | Fc gamma R-mediated phagocytosis | 2 | 0.018681 | 42 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004715 | non-membrane spanning protein tyrosine kinase activity | "Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2] | 2 | 0.004856 | 42 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0005404 | Increased total B cell count | The absolute number of B cells in the blood, per microlitre is above the upper limit of normal of the reference range for the appropriate sex and age-group. | 2 | 0.009125 | 42 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | Signaling by Receptor Tyrosine Kinases | 3 | 0.01878 | 42 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP23 | B cell receptor signaling | B cell receptor signaling | 2 | 0.021259 | 42 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0381203 | Placenta; hofbauer cells[High] | Placenta; hofbauer cells[High] | 2 | 0.042959 | 42 |
| HPA | HPA:0381222 | Placenta; syncytiotrophoblasts - microvilli[≥Medium] | Placenta; syncytiotrophoblasts - microvilli[≥Medium] | 2 | 0.049936 | 42 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2910 | PLC-gamma-2-Lyn-FcR-gamma complex | PLC-gamma-2-Lyn-FcR-gamma complex | 1 | 0.049932 | 42 |
Community 43
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04010 | MAPK signaling pathway | MAPK signaling pathway | 2 | 0.033193 | 43 |
Community 44
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0461423 | Skin 1; eccrine glands[High] | Skin 1; eccrine glands[High] | 2 | 0.004246 | 44 |
| HPA | HPA:0461493 | Skin 1; vascular mural cells[High] | Skin 1; vascular mural cells[High] | 2 | 0.009807 | 44 |
| HPA | HPA:0461422 | Skin 1; eccrine glands[≥Medium] | Skin 1; eccrine glands[≥Medium] | 2 | 0.018856 | 44 |
| HPA | HPA:0461492 | Skin 1; vascular mural cells[≥Medium] | Skin 1; vascular mural cells[≥Medium] | 2 | 0.019263 | 44 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 2 | 0.031617 | 44 |
| HPA | HPA:0461421 | Skin 1; eccrine glands[≥Low] | Skin 1; eccrine glands[≥Low] | 2 | 0.032674 | 44 |
Community 45
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006739 | NADP metabolic process | "The chemical reactions and pathways involving nicotinamide adenine dinucleotide phosphate (NADP+), a coenzyme that interconverts with its reduced form, NADPH, in many redox and biosynthetic reactions." [GOC:mah] | 2 | 0.005558 | 45 |
| GO:BP | GO:0043648 | dicarboxylic acid metabolic process | "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] | 2 | 0.032819 | 45 |
| GO:BP | GO:0019752 | carboxylic acid metabolic process | "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] | 3 | 0.037416 | 45 |
| GO:BP | GO:0043436 | oxoacid metabolic process | "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] | 3 | 0.040273 | 45 |
| GO:BP | GO:0006082 | organic acid metabolic process | "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] | 3 | 0.041077 | 45 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00480 | Glutathione metabolism | Glutathione metabolism | 2 | 0.006329 | 45 |
| KEGG | KEGG:01200 | Carbon metabolism | Carbon metabolism | 2 | 0.026813 | 45 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0050661 | NADP binding | "Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai] | 2 | 0.006758 | 45 |
| GO:MF | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-] | 2 | 0.037310 | 45 |
| GO:MF | GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] | 2 | 0.043583 | 45 |
| GO:MF | GO:0004587 | ornithine aminotransferase activity | "Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde." [EC:2.6.1.13] | 1 | 0.049724 | 45 |
| GO:MF | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity | "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44] | 1 | 0.049724 | 45 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3925 | Amino acid metabolism | Amino acid metabolism | 2 | 0.020798 | 45 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:404 | Isocitrate dehydrogenase [NADP], cytoplasmic | Isocitrate dehydrogenase [NADP], cytoplasmic | 1 | 0.024966 | 45 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 2 | 0.040296 | 45 |
| REAC | REAC:R-HSA-2978092 | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | 1 | 0.049932 | 45 |
Community 46
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0060348 | bone development | "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph] | 3 | 0.000565 | 46 |
| GO:BP | GO:0001501 | skeletal system development | "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb] | 3 | 0.008424 | 46 |
| GO:BP | GO:0048589 | developmental growth | "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] | 3 | 0.015608 | 46 |
| GO:BP | GO:0040007 | growth | "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] | 3 | 0.042994 | 46 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0005871 | Metaphyseal chondrodysplasia | An abnormality of skeletal development characterized by a disturbance of the metaphysis and its histological structure with relatively normal epiphyses and vertebrae. | 2 | 0.015092 | 46 |
| HP | HP:0000919 | Abnormality of the costochondral junction | Any anomaly of the costochondral junction. The costochondral junctions are located between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum. | 2 | 0.034795 | 46 |
| HP | HP:0003375 | Narrow greater sciatic notch | A narrowing of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium. | 2 | 0.034795 | 46 |
| HP | HP:0010456 | Abnormal greater sciatic notch morphology | An abnormality of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium. | 2 | 0.038269 | 46 |
| HP | HP:0006489 | Abnormal femoral metaphysis morphology | An anomaly of the femoral metaphysis. | 2 | 0.041909 | 46 |
| HP | HP:0006490 | Abnormal lower-limb metaphysis morphology | Abnormal lower-limb metaphysis morphology | 2 | 0.049681 | 46 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-8853334 | Signaling by FGFR3 fusions in cancer | Signaling by FGFR3 fusions in cancer | 1 | 0.049932 | 46 |
| REAC | REAC:R-HSA-2033515 | t(4;14) translocations of FGFR3 | t(4;14) translocations of FGFR3 | 1 | 0.049932 | 46 |
Community 47
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP1982 | Sterol regulatory element binding proteins SREBP signaling | Sterol regulatory element binding proteins SREBP signaling | 2 | 0.011935 | 47 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-219-1-3p | hsa-mir-219-1-3p | hsa-mir-219-1-3p | 3 | 0.014276 | 47 |
| MIRNA | MIRNA:hsa-mir-6879-3p | hsa-mir-6879-3p | hsa-mir-6879-3p | 2 | 0.040381 | 47 |
| MIRNA | MIRNA:hsa-mir-7152-5p | hsa-mir-7152-5p | hsa-mir-7152-5p | 2 | 0.043652 | 47 |
Community 50
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1982 | CACY homodimer complex | CACY homodimer complex | 1 | 0.049932 | 50 |
Community 51
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990811 | MWP complex | "A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin." [PMID:25987607, PMID:29021344] | 1 | 0.02499 | 51 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0450623 | Skin; secretory cells[High] | Skin; secretory cells[High] | 1 | 0.035757 | 51 |
| HPA | HPA:0450633 | Skin; sweat ducts[High] | Skin; sweat ducts[High] | 1 | 0.035757 | 51 |
| HPA | HPA:0450632 | Skin; sweat ducts[≥Medium] | Skin; sweat ducts[≥Medium] | 1 | 0.047674 | 51 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5213 | Amino acid metabolism in triple negative breast cancer cells | Amino acid metabolism in triple negative breast cancer cells | 1 | 0.043706 | 51 |
| WP | WP:WP4688 | Serine metabolism | Serine metabolism | 1 | 0.049950 | 51 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004617 | phosphoglycerate dehydrogenase activity | "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] | 1 | 0.049724 | 51 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0007525 | Yellow subcutaneous tissue covered by thin, scaly skin | Yellow subcutaneous tissue covered by thin, scaly skin | 1 | 0.049962 | 51 |
| HP | HP:0034691 | Reduced 3-phosphoglycerate dehydrogenase activity | Diminished activity of the enzyme 3-phosphoglycerate dehydrogenase (PGDH), which catalyzes the first step in the pathway by converting D-3-phosphoglycerate (PGA), an intermediate in glycolysis, to phosphohydroxypyruvate concomitant with the reduction of NAD+. | 1 | 0.049962 | 51 |
Community 52
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0170034 | L-amino acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of L-amino acids, the L-enantiomers of amino acids." [GOC:edw] | 2 | 0.009336 | 52 |
| GO:BP | GO:0170038 | proteinogenic amino acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew] | 2 | 0.010433 | 52 |
| GO:BP | GO:0170041 | non-proteinogenic amino acid metabolic process | "The chemical reactions and pathways involving non-proteingenic amino acids." [GOC:ew] | 2 | 0.014087 | 52 |
| GO:BP | GO:1901607 | alpha-amino acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie] | 2 | 0.015427 | 52 |
| GO:BP | GO:0008652 | amino acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732] | 2 | 0.019809 | 52 |
| GO:BP | GO:0043648 | dicarboxylic acid metabolic process | "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] | 2 | 0.032819 | 52 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-203a-5p | hsa-mir-203a-5p | hsa-mir-203a-5p | 2 | 0.010624 | 52 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004349 | glutamate 5-kinase activity | "Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+." [EC:2.7.2.11, RHEA:14877] | 1 | 0.049724 | 52 |
| GO:MF | GO:0004350 | glutamate-5-semialdehyde dehydrogenase activity | "Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH." [EC:1.2.1.41, RHEA:19541] | 1 | 0.049724 | 52 |
Community 53
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 3 | 5.609630e-07 | 53 |
| REAC | REAC:R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 3 | 5.609630e-07 | 53 |
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3 | 5.890111e-06 | 53 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 3 | 6.959240e-06 | 53 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 3 | 1.337649e-05 | 53 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 3 | 1.337649e-05 | 53 |
| REAC | REAC:R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | Drug-mediated inhibition of CDK4/CDK6 activity | 2 | 9.074401e-05 | 53 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 3 | 4.367229e-04 | 53 |
| REAC | REAC:R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | Regulation of RUNX1 Expression and Activity | 2 | 1.233221e-03 | 53 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 3 | 2.262634e-02 | 53 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 3 | 4.285112e-02 | 53 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097133 | cyclin D3-CDK6 complex | "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 0.000002 | 53 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 2 | 0.005130 | 53 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 2 | 0.021554 | 53 |
| GO:CC | GO:0097132 | cyclin D2-CDK6 complex | "A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 1 | 0.024990 | 53 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 2 | 0.026121 | 53 |
| GO:CC | GO:0097130 | cyclin D3-CDK4 complex | "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 1 | 0.049978 | 53 |
| GO:CC | GO:0097131 | cyclin D1-CDK6 complex | "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 1 | 0.049978 | 53 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 3 | 0.000016 | 53 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 3 | 0.000016 | 53 |
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 2 | 0.005533 | 53 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 3 | 0.006951 | 53 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 3 | 0.019563 | 53 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 3 | 0.029976 | 53 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 3 | 0.040321 | 53 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 3 | 0.000024 | 53 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 3 | 0.000164 | 53 |
| WP | WP:WP1545 | miRNAs involved in DNA damage response | miRNAs involved in DNA damage response | 2 | 0.011590 | 53 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 2 | 0.011935 | 53 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 2 | 0.013366 | 53 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 2 | 0.019892 | 53 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 2 | 0.022670 | 53 |
| WP | WP:WP4258 | lncRNA in canonical Wnt signaling and colorectal cancer | lncRNA in canonical Wnt signaling and colorectal cancer | 2 | 0.023637 | 53 |
| WP | WP:WP4630 | Measles virus infection | Measles virus infection | 2 | 0.046464 | 53 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 3 | 0.000308 | 53 |
| KEGG | KEGG:04115 | p53 signaling pathway | p53 signaling pathway | 2 | 0.011084 | 53 |
| KEGG | KEGG:05162 | Measles | Measles | 2 | 0.038597 | 53 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 2 | 0.048665 | 53 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 3 | 0.006368 | 53 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 3 | 0.038053 | 53 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6836-5p | hsa-mir-6836-5p | hsa-mir-6836-5p | 2 | 0.024035 | 53 |
| MIRNA | MIRNA:hsa-mir-6132 | hsa-mir-6132 | hsa-mir-6132 | 2 | 0.024658 | 53 |
| MIRNA | MIRNA:hsa-mir-34a-3p | hsa-mir-34a-3p | hsa-mir-34a-3p | 2 | 0.025289 | 53 |
| MIRNA | MIRNA:hsa-mir-138-5p | hsa-mir-138-5p | hsa-mir-138-5p | 2 | 0.044490 | 53 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5100 | CyclinD3-CDK4-CDK6 complex | CyclinD3-CDK4-CDK6 complex | 1 | 0.024966 | 53 |
| CORUM | CORUM:3088 | CCND2-CDK6 complex | CCND2-CDK6 complex | 1 | 0.024966 | 53 |
| CORUM | CORUM:3089 | CCND3-CDK6 complex | CCND3-CDK6 complex | 1 | 0.024966 | 53 |
| CORUM | CORUM:3087 | CCND1-CDK6 complex | CCND1-CDK6 complex | 1 | 0.049932 | 53 |
| CORUM | CORUM:5101 | CyclinD3-CDK4-CDK6-p21 complex | CyclinD3-CDK4-CDK6-p21 complex | 1 | 0.049932 | 53 |
| CORUM | CORUM:1633 | CyclinD1-CDK4-CDK6 complex | CyclinD1-CDK4-CDK6 complex | 1 | 0.049932 | 53 |
Community 54
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 3 | 0.007022 | 54 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 3 | 0.011771 | 54 |
| GO:CC | GO:0005814 | centriole | "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] | 2 | 0.029287 | 54 |
Community 56
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0061656 | SUMO conjugating enzyme activity | "Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue." [GOC:dph] | 1 | 0.049724 | 56 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005816 | spindle pole body | "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568] | 1 | 0.049978 | 56 |
Community 57
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:01232 | Nucleotide metabolism | Nucleotide metabolism | 2 | 0.014295 | 57 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0001651 | dense fibrillar component | "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561] | 1 | 0.02499 | 57 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-15869 | Metabolism of nucleotides | Metabolism of nucleotides | 2 | 0.036966 | 57 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0009201 | ribonucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 2 | 0.047469 | 57 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0034512 | box C/D sno(s)RNA binding | "Binding to a box C/D small nucleolar RNA." [GOC:mah] | 1 | 0.049724 | 57 |
Community 58
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:433 | BASC complex (BRCA1-associated genome surveillance complex) | BASC complex (BRCA1-associated genome surveillance complex) | 2 | 0.000974 | 58 |
| CORUM | CORUM:1132 | RFC2-RIalpha complex | RFC2-RIalpha complex | 1 | 0.049932 | 58 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | Impaired BRCA2 binding to RAD51 | 2 | 0.002700 | 58 |
| REAC | REAC:R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | HDR through Single Strand Annealing (SSA) | 2 | 0.003022 | 58 |
| REAC | REAC:R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | Presynaptic phase of homologous DNA pairing and strand exchange | 2 | 0.003540 | 58 |
| REAC | REAC:R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2 | 0.003721 | 58 |
| REAC | REAC:R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | Diseases of DNA Double-Strand Break Repair | 2 | 0.003721 | 58 |
| REAC | REAC:R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | Homologous DNA Pairing and Strand Exchange | 2 | 0.004098 | 58 |
| REAC | REAC:R-HSA-9675135 | Diseases of DNA repair | Diseases of DNA repair | 2 | 0.005559 | 58 |
| REAC | REAC:R-HSA-5685942 | HDR through Homologous Recombination (HRR) | HDR through Homologous Recombination (HRR) | 2 | 0.010959 | 58 |
| REAC | REAC:R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Regulation of TP53 Activity through Phosphorylation | 2 | 0.018996 | 58 |
| REAC | REAC:R-HSA-69473 | G2/M DNA damage checkpoint | G2/M DNA damage checkpoint | 2 | 0.019836 | 58 |
| REAC | REAC:R-HSA-5693607 | Processing of DNA double-strand break ends | Processing of DNA double-strand break ends | 2 | 0.021129 | 58 |
| REAC | REAC:R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2 | 0.040438 | 58 |
| REAC | REAC:R-HSA-5693538 | Homology Directed Repair | Homology Directed Repair | 2 | 0.044155 | 58 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0022616 | DNA strand elongation | "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:isa_complete, GOC:mah] | 2 | 0.004515 | 58 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 2 | 0.006248 | 58 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003678 | DNA helicase activity | "Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl] | 2 | 0.008389 | 58 |
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 2 | 0.037310 | 58 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 2 | 0.035583 | 58 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 3 | 0.03919 | 58 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M01116 | Factor: CLOCK:BMAL; motif: MCACGTGR | Factor: CLOCK:BMAL; motif: MCACGTGR | 3 | 0.040767 | 58 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0100953 | Enlarged interhemispheric fissure | Enlarged interhemispheric fissure | 1 | 0.049962 | 58 |
Community 59
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0031492 | nucleosomal DNA binding | "Binding to the DNA portion of a nucleosome." [GOC:mah] | 2 | 0.005449 | 59 |
| GO:MF | GO:0031491 | nucleosome binding | "Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah] | 2 | 0.012199 | 59 |
| GO:MF | GO:0031490 | chromatin DNA binding | "Binding to DNA that is assembled into chromatin." [GOC:mah] | 2 | 0.027539 | 59 |
Community 60
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M02273_1 | Factor: NURR1; motif: AAGGTCAC; match class: 1 | Factor: NURR1; motif: AAGGTCAC; match class: 1 | 3 | 0.016994 | 60 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-3675-5p | hsa-mir-3675-5p | hsa-mir-3675-5p | 3 | 0.019261 | 60 |
| MIRNA | MIRNA:hsa-mir-4761-3p | hsa-mir-4761-3p | hsa-mir-4761-3p | 3 | 0.028544 | 60 |
| MIRNA | MIRNA:hsa-mir-4648 | hsa-mir-4648 | hsa-mir-4648 | 3 | 0.035726 | 60 |
| MIRNA | MIRNA:hsa-mir-4489 | hsa-mir-4489 | hsa-mir-4489 | 3 | 0.047500 | 60 |
Community 61
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11100 | Factor: Max; motif: NNCACGTGYN | Factor: Max; motif: NNCACGTGYN | 2 | 0.029729 | 61 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0009898 | cytoplasmic side of plasma membrane | "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] | 2 | 0.030383 | 61 |
| GO:CC | GO:0098562 | cytoplasmic side of membrane | "The side of a membrane that faces the cytoplasm." [GOC:dos] | 2 | 0.049212 | 61 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004638 | phosphoribosylaminoimidazole carboxylase activity | "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2." [EC:4.1.1.21, RHEA:10792] | 1 | 0.049724 | 61 |
| GO:MF | GO:0004639 | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate." [EC:6.3.2.6, RHEA:22628] | 1 | 0.049724 | 61 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00740 | Riboflavin metabolism | Riboflavin metabolism | 1 | 0.049871 | 61 |
Community 62
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006270 | DNA replication initiation | "The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641] | 2 | 0.004515 | 62 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00073_1 | Factor: deltaEF1; motif: NNNCACCTNAN; match class: 1 | Factor: deltaEF1; motif: NNNCACCTNAN; match class: 1 | 2 | 0.004963 | 62 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6140 | Cdt1-Geminin complex | Cdt1-Geminin complex | 1 | 0.049932 | 62 |
Community 63
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016874 | ligase activity | "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-] | 2 | 0.037951 | 63 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0070981 | L-asparagine biosynthetic process | "The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [GOC:mah] | 1 | 0.049542 | 63 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11943_1 | Factor: POU4F3; motif: ATNAATWATKCAT; match class: 1 | Factor: POU4F3; motif: ATNAATWATKCAT; match class: 1 | 1 | 0.049771 | 63 |
Community 65
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-4341670 | Defective NEU1 causes sialidosis | Defective NEU1 causes sialidosis | 2 | 0.000027 | 65 |
| REAC | REAC:R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | Diseases associated with N-glycosylation of proteins | 2 | 0.001723 | 65 |
| REAC | REAC:R-HSA-4085001 | Sialic acid metabolism | Sialic acid metabolism | 2 | 0.004783 | 65 |
| REAC | REAC:R-HSA-9840310 | Glycosphingolipid catabolism | Glycosphingolipid catabolism | 2 | 0.005706 | 65 |
| REAC | REAC:R-HSA-1660662 | Glycosphingolipid metabolism | Glycosphingolipid metabolism | 2 | 0.013435 | 65 |
| REAC | REAC:R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | Synthesis of substrates in N-glycan biosythesis | 2 | 0.017660 | 65 |
| REAC | REAC:R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | 2 | 0.027130 | 65 |
| REAC | REAC:R-HSA-428157 | Sphingolipid metabolism | Sphingolipid metabolism | 2 | 0.046467 | 65 |
| REAC | REAC:R-HSA-2206308 | MPS IV - Morquio syndrome B | MPS IV - Morquio syndrome B | 1 | 0.049932 | 65 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0008166 | Decreased beta-galactosidase activity | Abnormally decreased rate of beta-galactosidase activity. Beta-galactosidase activity can be measured in leukocyte, fibroblast, or plasma. | 2 | 0.000498 | 65 |
| HP | HP:0004342 | Abnormal galactosidase enyzme activity | Abnormality of galactoside metabolism. A galactoside is a glycoside (a sugar moiety bound to some other moiety) containing galactose. | 2 | 0.000498 | 65 |
| HP | HP:0003649 | Abnormal glycosidase enzyme activity | Abnormality of glycosidase enzyme activity. Glycoside hydrolases (GHs), including glycosidases and transglycosidases. These enzymes constitute 113 protein families that are responsible for the hydrolysis and/or transglycosylation of glycosidic bonds. | 2 | 0.000498 | 65 |
| HP | HP:0010729 | Cherry red spot of the macula | Pallor of the perifoveal macula of the retina with appearance of a small circular reddish choroid shape as seen through the fovea centralis due to relative transparency of the macula. | 2 | 0.012937 | 65 |
| HP | HP:0000943 | Dysostosis multiplex | Dysostosis multiplex | 2 | 0.041909 | 65 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04142 | Lysosome | Lysosome | 2 | 0.00626 | 65 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0035578 | azurophil granule lumen | "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] | 2 | 0.009216 | 65 |
| GO:CC | GO:0043202 | lysosomal lumen | "The volume enclosed within the lysosomal membrane." [GOC:jl, PMID:15213228] | 2 | 0.011137 | 65 |
| GO:CC | GO:0005766 | primary lysosome | "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] | 2 | 0.026809 | 65 |
| GO:CC | GO:0042582 | azurophil granule | "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule] | 2 | 0.026809 | 65 |
| GO:CC | GO:0005775 | vacuolar lumen | "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] | 2 | 0.036160 | 65 |
| GO:CC | GO:0098575 | lumenal side of lysosomal membrane | "The side (leaflet) of the lysosomal membrane that faces the lumen." [GOC:dos] | 1 | 0.049978 | 65 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2858 | Ectoderm differentiation | Ectoderm differentiation | 2 | 0.049937 | 65 |
Community 66
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11093_1 | Factor: USF1; motif: ANCATGTGACN; match class: 1 | Factor: USF1; motif: ANCATGTGACN; match class: 1 | 3 | 0.005059 | 66 |
| TF | TF:M11048_1 | Factor: BMAL1; motif: RTCAYGTGMN; match class: 1 | Factor: BMAL1; motif: RTCAYGTGMN; match class: 1 | 3 | 0.005663 | 66 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0048708 | astrocyte differentiation | "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:vp, PMID:15139015] | 2 | 0.024738 | 66 |
| GO:BP | GO:0030641 | regulation of cellular pH | "Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb] | 2 | 0.029576 | 66 |
| GO:BP | GO:0006885 | regulation of pH | "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb] | 2 | 0.036932 | 66 |
Community 67
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] | 2 | 0.021391 | 67 |
Community 68
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4931 | Direct reversal repair | Direct reversal repair | 1 | 0.029803 | 68 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003908 | methylated-DNA-[protein]-cysteine S-methyltransferase activity | "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63] | 1 | 0.049724 | 68 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5657655 | MGMT-mediated DNA damage reversal | MGMT-mediated DNA damage reversal | 1 | 0.049932 | 68 |
Community 69
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005885 | Arp2/3 protein complex | "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800] | 2 | 0.000124 | 69 |
| GO:CC | GO:0036284 | tubulobulbar complex | "Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes." [GOC:sl, PMID:22510523] | 1 | 0.049978 | 69 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | Bacterial invasion of epithelial cells | 2 | 0.002151 | 69 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | Fc gamma R-mediated phagocytosis | 2 | 0.003352 | 69 |
| KEGG | KEGG:05135 | Yersinia infection | Yersinia infection | 2 | 0.006749 | 69 |
| KEGG | KEGG:04530 | Tight junction | Tight junction | 2 | 0.010561 | 69 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 2 | 0.014193 | 69 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 2 | 0.018858 | 69 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 2 | 0.022154 | 69 |
| KEGG | KEGG:04144 | Endocytosis | Endocytosis | 2 | 0.022517 | 69 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 2 | 0.022699 | 69 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2272 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 2 | 0.007563 | 69 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0034314 | Arp2/3 complex-mediated actin nucleation | "The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983] | 2 | 0.007644 | 69 |
| GO:BP | GO:0045010 | actin nucleation | "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194] | 2 | 0.012808 | 69 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011896 | Subconjunctival hemorrhage | Bleeding beneath the mucous membrane that lines the inner surface of the eyelid. | 1 | 0.049962 | 69 |
Community 70
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0001181 | RNA polymerase I general transcription initiation factor activity | "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs." [GOC:txnOH-2018, PMID:11500378, PMID:17972917, PMID:25346433, PMID:28340337, PMID:28842442, PMID:31358304] | 2 | 0.000049 | 70 |
| GO:MF | GO:0001163 | RNA polymerase I transcription regulatory region sequence-specific DNA binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH] | 2 | 0.000177 | 70 |
| GO:MF | GO:0001164 | RNA polymerase I core promoter sequence-specific DNA binding | "Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] | 2 | 0.000177 | 70 |
| GO:MF | GO:0001046 | core promoter sequence-specific DNA binding | "Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH] | 2 | 0.004224 | 70 |
| GO:MF | GO:0140223 | general transcription initiation factor activity | "A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018] | 2 | 0.009271 | 70 |
| GO:MF | GO:0001165 | RNA polymerase I cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element)." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] | 1 | 0.049724 | 70 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0001188 | RNA polymerase I preinitiation complex assembly | "The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which includes including UBF, SL1, RRN3 and TBP in human). The PIC engages RNA polymerase I on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH, PMID:14969726] | 2 | 0.000305 | 70 |
| GO:BP | GO:0006361 | transcription initiation at RNA polymerase I promoter | "A transcription initiation process that takes place at a RNA polymerase I gene promoter. Ribosomal RNAs (rRNA) genes are transcribed by RNA polymerase I." [GOC:txnOH] | 2 | 0.000529 | 70 |
| GO:BP | GO:0065004 | protein-DNA complex assembly | "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] | 3 | 0.000744 | 70 |
| GO:BP | GO:0071824 | protein-DNA complex organization | "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." [GOC:mah] | 3 | 0.000956 | 70 |
| GO:BP | GO:0006360 | transcription by RNA polymerase I | "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] | 2 | 0.016827 | 70 |
| GO:BP | GO:0070897 | transcription preinitiation complex assembly | "The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH] | 2 | 0.022480 | 70 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-73762 | RNA Polymerase I Transcription Initiation | RNA Polymerase I Transcription Initiation | 2 | 0.009784 | 70 |
| REAC | REAC:R-HSA-73772 | RNA Polymerase I Promoter Escape | RNA Polymerase I Promoter Escape | 2 | 0.036156 | 70 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 3 | 0.043826 | 70 |
Community 71
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6118 | Hook1-Vps39 complex | Hook1-Vps39 complex | 1 | 0.049932 | 71 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1902500 | vacuolar HOPS complex | "Any HOPS complex that is part of a vacuolar membrane." [GOC:TermGenie, PMID:23645161] | 1 | 0.049978 | 71 |
| GO:CC | GO:1902501 | lysosomal HOPS complex | "Any HOPS complex that is part of a lysosomal membrane." [GOC:TermGenie, PMID:23645161] | 1 | 0.049978 | 71 |
Community 72
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 3 | 0.002571 | 72 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 3 | 0.012840 | 72 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 2 | 0.018858 | 72 |
Community 73
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2755 | 17S U2 snRNP | 17S U2 snRNP | 3 | 0.000035 | 73 |
| CORUM | CORUM:351 | Spliceosome | Spliceosome | 3 | 0.003747 | 73 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 3 | 0.00042 | 73 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-72163 | mRNA Splicing - Major Pathway | mRNA Splicing - Major Pathway | 3 | 0.001116 | 73 |
| REAC | REAC:R-HSA-72172 | mRNA Splicing | mRNA Splicing | 3 | 0.001237 | 73 |
| REAC | REAC:R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | Processing of Capped Intron-Containing Pre-mRNA | 3 | 0.002859 | 73 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 3 | 0.049002 | 73 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0071011 | precatalytic spliceosome | "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] | 2 | 0.003470 | 73 |
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 2 | 0.049212 | 73 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP411 | mRNA processing | mRNA processing | 2 | 0.008941 | 73 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000380 | alternative mRNA splicing, via spliceosome | "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] | 2 | 0.016827 | 73 |
Community 74
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0033593 | BRCA2-MAGE-D1 complex | "A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth." [PMID:15930293] | 1 | 0.02499 | 74 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0000075 | Renal duplication | A congenital anomaly of the urinary tract, in which the kidney is duplicated and is drained via two separate renal pelves and ureters. | 2 | 0.042597 | 74 |
| HP | HP:0005217 | Abdominal organ duplication | A congenital malformation characterized by the development of an additional organ or organ-like structure, i.e., an extra copy of the organ normally located in the abdomen. | 2 | 0.042597 | 74 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-1245a | hsa-mir-1245a | hsa-mir-1245a | 2 | 0.045336 | 74 |
Community 75
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004648 | O-phospho-L-serine:2-oxoglutarate aminotransferase activity | "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52] | 1 | 0.049724 | 75 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034390 | Decreased CSF glycine concentration | Abnormally decreased levels of glycine in cerebrospinal fluid. | 1 | 0.049962 | 75 |
| HP | HP:0500226 | Abnormal CSF serine concentration | Any deviation from the normal concentration of serine in the cerebrospinal fluid. | 1 | 0.049962 | 75 |
| HP | HP:0500228 | Decreased CSF serine concentration | Abnormally decreased levels of serine in cerebrospinal fluid. | 1 | 0.049962 | 75 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0099631 | postsynaptic endocytic zone cytoplasmic component | "The cytoplasmic component of the postsynaptic endocytic zone." [GOC:dos] | 1 | 0.049978 | 75 |
Community 76
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP712 | Estrogen signaling | Estrogen signaling | 2 | 0.001292 | 76 |
| WP | WP:WP3981 | miRNA regulation of prostate cancer signaling | miRNA regulation of prostate cancer signaling | 2 | 0.002373 | 76 |
| WP | WP:WP5477 | Molecular pathway for oxidative stress | Molecular pathway for oxidative stress | 2 | 0.005992 | 76 |
| WP | WP:WP254 | Apoptosis | Apoptosis | 2 | 0.019006 | 76 |
| WP | WP:WP1438 | Influenza A virus infection | Influenza A virus infection | 1 | 0.022375 | 76 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 2 | 0.022670 | 76 |
| WP | WP:WP4630 | Measles virus infection | Measles virus infection | 2 | 0.046464 | 76 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043276 | anoikis | "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, PMID:37667281] | 2 | 0.001402 | 76 |
| GO:BP | GO:0050851 | antigen receptor-mediated signaling pathway | "The series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell." [GOC:add] | 2 | 0.044570 | 76 |
| GO:BP | GO:0032848 | negative regulation of cellular pH reduction | "Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] | 1 | 0.049542 | 76 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 2 | 0.003077 | 76 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 2 | 0.003423 | 76 |
| KEGG | KEGG:04064 | NF-kappa B signaling pathway | NF-kappa B signaling pathway | 2 | 0.003787 | 76 |
| KEGG | KEGG:05145 | Toxoplasmosis | Toxoplasmosis | 2 | 0.004248 | 76 |
| KEGG | KEGG:04210 | Apoptosis | Apoptosis | 2 | 0.006650 | 76 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | Fluid shear stress and atherosclerosis | 2 | 0.006950 | 76 |
| KEGG | KEGG:05162 | Measles | Measles | 2 | 0.006950 | 76 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 2 | 0.009587 | 76 |
| KEGG | KEGG:04621 | NOD-like receptor signaling pathway | NOD-like receptor signaling pathway | 2 | 0.012109 | 76 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 2 | 0.014338 | 76 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | Human immunodeficiency virus 1 infection | 2 | 0.016133 | 76 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | Lipid and atherosclerosis | 2 | 0.016755 | 76 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 2 | 0.022154 | 76 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 2 | 0.022699 | 76 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 2 | 0.046455 | 76 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 2 | 0.013435 | 76 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-617 | hsa-mir-617 | hsa-mir-617 | 3 | 0.041489 | 76 |
| MIRNA | MIRNA:hsa-mir-526b | hsa-mir-526b | hsa-mir-526b | 3 | 0.042743 | 76 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5730 | IKBKG homotrimer complex | IKBKG homotrimer complex | 1 | 0.049932 | 76 |
| CORUM | CORUM:2123 | IKBKG homodimer complex | IKBKG homodimer complex | 1 | 0.049932 | 76 |
| CORUM | CORUM:5827 | IKBKG homotetramer complex | IKBKG homotetramer complex | 1 | 0.049932 | 76 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097138 | BAD-BCL-2 complex | "A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] | 1 | 0.049978 | 76 |
Community 77
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-548az-5p | hsa-mir-548az-5p | hsa-mir-548az-5p | 2 | 0.035004 | 77 |
| MIRNA | MIRNA:hsa-mir-548t-5p | hsa-mir-548t-5p | hsa-mir-548t-5p | 2 | 0.035004 | 77 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6212 | GM130-GRASP65 complex | GM130-GRASP65 complex | 1 | 0.049932 | 77 |
Community 78
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0071919 | G-quadruplex DNA formation | "A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature." [GOC:sre, PMID:20098422] | 1 | 0.049542 | 78 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06974 | Factor: PRRX2; motif: WTAATCTGATTAT | Factor: PRRX2; motif: WTAATCTGATTAT | 1 | 0.049771 | 78 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0007889 | Iridescent posterior subcapsular cataract | A type of posterior subcapsular cataract characterized by an iridescent color. | 1 | 0.049962 | 78 |
Community 81
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11808_1 | Factor: RAR-gamma; motif: NAGGTCANG; match class: 1 | Factor: RAR-gamma; motif: NAGGTCANG; match class: 1 | 2 | 0.018587 | 81 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0015317 | phosphate:proton symporter activity | "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-] | 1 | 0.024946 | 81 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1990547 | mitochondrial phosphate ion transmembrane transport | "The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9099701] | 1 | 0.049542 | 81 |
Community 82
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0000140 | acylglycerone-phosphate reductase (NADP+) activity | "Catalysis of the reaction: 1-hexadecanoyl-sn-glycero-3-phosphate + NADP+ = 1-hexadecanoylglycerone 3-phosphate + H+ + NADPH." [RHEA:17341] | 1 | 0.049891 | 82 |
Community 84
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-589-5p | hsa-mir-589-5p | hsa-mir-589-5p | 2 | 0.001879 | 84 |
| MIRNA | MIRNA:hsa-mir-7153-5p | hsa-mir-7153-5p | hsa-mir-7153-5p | 2 | 0.003047 | 84 |
| MIRNA | MIRNA:hsa-mir-146a-5p | hsa-mir-146a-5p | hsa-mir-146a-5p | 2 | 0.020770 | 84 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0008653 | Crescentic glomerulonephritis | A type of extracapillary glomerulonephritis characterized by the formation of crescent-like cellular proliferation. | 1 | 0.049962 | 84 |
Community 85
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002192 | IRES-dependent translational initiation of linear mRNA | "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation." [PMID:17284590] | 1 | 0.049542 | 85 |
| GO:BP | GO:0110017 | cap-independent translational initiation of linear mRNA | "The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation." [GOC:kmv] | 1 | 0.049542 | 85 |
Community 86
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0036116 | long-chain fatty-acyl-CoA catabolic process | "The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:pm] | 1 | 0.049542 | 86 |
| GO:BP | GO:1900533 | palmitic acid metabolic process | "The chemical reactions and pathways involving palmitic acid." [GOC:TermGenie] | 1 | 0.049542 | 86 |
| GO:BP | GO:1900535 | palmitic acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of palmitic acid." [GOC:TermGenie] | 1 | 0.049542 | 86 |
Community 88
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 2 | 0.008774 | 88 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:2000781 | positive regulation of double-strand break repair | "Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF] | 2 | 0.010080 | 88 |
| GO:BP | GO:0045739 | positive regulation of DNA repair | "Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators] | 2 | 0.021952 | 88 |
| GO:BP | GO:2000779 | regulation of double-strand break repair | "Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF] | 2 | 0.023924 | 88 |
| GO:BP | GO:0051658 | maintenance of nucleus location | "Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] | 1 | 0.049542 | 88 |
| GO:BP | GO:2000655 | negative regulation of cellular response to testosterone stimulus | "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF] | 1 | 0.049542 | 88 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-325-3p | hsa-mir-325-3p | hsa-mir-325-3p | 1 | 0.018269 | 88 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0032041 | histone H3K14 deacetylase activity, NAD-dependent | "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + NAD+ + H2O = histone H3 L-lysine (position 14) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K14 to NAD, producing nicotinamide." [PMID:28450737] | 1 | 0.049891 | 88 |
| GO:MF | GO:0140937 | histone H4K12 deacetylase activity, hydrolytic mechanism | "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein." [GOC:vw, PMID:15293224] | 1 | 0.049891 | 88 |
| GO:MF | GO:0141208 | NAD-dependent protein lysine delactylase activity | "Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, transfering a lactoyl group attached to a lysine residue in a protein to NAD." [PMID:38512451, RHEA:80287] | 1 | 0.049891 | 88 |
| GO:MF | GO:0160011 | NAD-dependent protein decrotonylase activity | "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [PMID:28497810] | 1 | 0.049891 | 88 |
| GO:MF | GO:0160012 | NAD-dependent histone decrotonylase activity | "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone] + nicotinamide." [PMID:28497810] | 1 | 0.049891 | 88 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2592 | SIRT1 homotrimer complex | SIRT1 homotrimer complex | 1 | 0.049932 | 88 |
Community 91
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:299 | IRF3-CBP complex | IRF3-CBP complex | 1 | 0.049932 | 91 |
Community 92
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0008681 | 2-octaprenyl-6-methoxyphenol hydroxylase activity | "Catalysis of the reaction: 2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP+." [PMID:27822549, PMID:4572721, RHEA:29407] | 1 | 0.049891 | 92 |
| GO:MF | GO:0106364 | 4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity | "Catalysis of the reaction: 4-hydroxy-3-all-trans-polyprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]." [PMID:38425362, RHEA:81195] | 1 | 0.049891 | 92 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1248 | Apoptosome | Apoptosome | 1 | 0.049932 | 92 |
Community 93
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | "Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf] | 2 | 0.000214 | 93 |
| GO:BP | GO:0051895 | negative regulation of focal adhesion assembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai] | 2 | 0.000283 | 93 |
| GO:BP | GO:0150118 | negative regulation of cell-substrate junction organization | "Any process that stops, prevents or reduces the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] | 2 | 0.000283 | 93 |
| GO:BP | GO:1900027 | regulation of ruffle assembly | "Any process that modulates the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf] | 2 | 0.001096 | 93 |
| GO:BP | GO:1901889 | negative regulation of cell junction assembly | "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] | 2 | 0.001096 | 93 |
| GO:BP | GO:0001953 | negative regulation of cell-matrix adhesion | "Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd] | 2 | 0.001484 | 93 |
| GO:BP | GO:0010762 | regulation of fibroblast migration | "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] | 2 | 0.001656 | 93 |
| GO:BP | GO:0097178 | ruffle assembly | "The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42." [GOC:yaf, PMID:12556481, Wikipedia:Membrane_ruffling] | 2 | 0.002229 | 93 |
| GO:BP | GO:0010761 | fibroblast migration | "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:BHF, GOC:dph, GOC:tb] | 2 | 0.003372 | 93 |
| GO:BP | GO:0031529 | ruffle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell." [GOC:mah, PMID:10036235] | 2 | 0.003629 | 93 |
| GO:BP | GO:0010812 | negative regulation of cell-substrate adhesion | "Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] | 2 | 0.004171 | 93 |
| GO:BP | GO:1900024 | regulation of substrate adhesion-dependent cell spreading | "Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf] | 2 | 0.004456 | 93 |
| GO:BP | GO:0090109 | regulation of cell-substrate junction assembly | "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb] | 2 | 0.004602 | 93 |
| GO:BP | GO:0051893 | regulation of focal adhesion assembly | "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai] | 2 | 0.004602 | 93 |
| GO:BP | GO:0150116 | regulation of cell-substrate junction organization | "Any process that modulates the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] | 2 | 0.005368 | 93 |
| GO:BP | GO:0048041 | focal adhesion assembly | "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jid, GOC:mah] | 2 | 0.008412 | 93 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] | 2 | 0.010745 | 93 |
| GO:BP | GO:0150115 | cell-substrate junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 2 | 0.012378 | 93 |
| GO:BP | GO:0034446 | substrate adhesion-dependent cell spreading | "The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate." [GOC:mah, GOC:pf, PMID:17050732] | 2 | 0.012378 | 93 |
| GO:BP | GO:0001952 | regulation of cell-matrix adhesion | "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd] | 2 | 0.017392 | 93 |
| GO:BP | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." [GOC:krc] | 2 | 0.047836 | 93 |
| GO:BP | GO:0043087 | regulation of GTPase activity | "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] | 2 | 0.047836 | 93 |
| GO:BP | GO:0060491 | regulation of cell projection assembly | "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb] | 2 | 0.048790 | 93 |
| GO:BP | GO:0072356 | chromosome passenger complex localization to kinetochore | "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis." [GOC:mah] | 1 | 0.049542 | 93 |
Community 94
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0004817 | Drug-sensitive hemolytic anemia | A form of hemolytic anemia that is triggered by ingestion of certain drugs. | 1 | 0.049962 | 94 |
| HP | HP:0011905 | Reduced hemoglobin A | Hemoglobin A (HbA) contains two globin alpha chains and two globin beta chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decreased in the proportion of HbA below this limit, and can be seen in various forms of thalassemia. | 1 | 0.049962 | 94 |
| HP | HP:0011906 | Reduced beta/alpha synthesis ratio | A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia. | 1 | 0.049962 | 94 |
| HP | HP:0020058 | Abnormal red blood cell count | Any deviation from the normal number of red blood cells per volume in the circulation. | 1 | 0.049962 | 94 |
| HP | HP:0020059 | Increased red blood cell count | An abnormal elevation above the normal number of red blood cells per volume in the circulation. | 1 | 0.049962 | 94 |
| HP | HP:0030058 | Sickled erythrocytes | An irreversible distortion of the morphology of an erythrocyte such that the cells are elongated and curved, resembling the blade of a sickle (the hand-held agricultural tool traditionally used to harvest grains). | 1 | 0.049962 | 94 |
| HP | HP:0031090 | Finger dactylitis | Fingers appear swollen and plump owing to inflammation of the complete finger. | 1 | 0.049962 | 94 |
| HP | HP:0200023 | Priapism | A painful and harmful medical condition in which the erect penis doesn't return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours. | 1 | 0.049962 | 94 |
Community 95
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-209563 | Axonal growth stimulation | Axonal growth stimulation | 2 | 0.000027 | 95 |
| REAC | REAC:R-HSA-193634 | Axonal growth inhibition (RHOA activation) | Axonal growth inhibition (RHOA activation) | 2 | 0.000163 | 95 |
| REAC | REAC:R-HSA-193697 | p75NTR regulates axonogenesis | p75NTR regulates axonogenesis | 2 | 0.000204 | 95 |
| REAC | REAC:R-HSA-193704 | p75 NTR receptor-mediated signalling | p75 NTR receptor-mediated signalling | 2 | 0.021129 | 95 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | Neurotrophin signaling pathway | 2 | 0.005075 | 95 |
| KEGG | KEGG:03265 | Virion - Ebolavirus and Lyssavirus | Virion - Ebolavirus and Lyssavirus | 1 | 0.037408 | 95 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6754-5p | hsa-mir-6754-5p | hsa-mir-6754-5p | 2 | 0.011149 | 95 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007266 | Rho protein signal transduction | "An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf] | 2 | 0.024261 | 95 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5408 | Neurotrophin-3-p75 complex | Neurotrophin-3-p75 complex | 1 | 0.024966 | 95 |
| CORUM | CORUM:1794 | SORT1-NGFR complex | SORT1-NGFR complex | 1 | 0.049932 | 95 |
| CORUM | CORUM:5424 | NGF-p75 complex | NGF-p75 complex | 1 | 0.049932 | 95 |
Community 97
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0062073 | histone mRNA stem-loop binding complex | "A protein-containing complex composed of a stem-loop binding protein (in most species SLBP) and its interacting partner (SLIP1 or MIF4GD in most species) that binds to the histone mRNA (hmRNA) 3-prime-stem-loop structure. Facilitates hmRNA translation initiation and may also be involved in its processing and nuclear export." [GOC:bhm, PMID:18025107, PMID:23286197] | 1 | 0.041231 | 97 |
Community 98
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 2 | 0.011065 | 98 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 2 | 0.020427 | 98 |
| GO:CC | GO:0001651 | dense fibrillar component | "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561] | 1 | 0.020616 | 98 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0034512 | box C/D sno(s)RNA binding | "Binding to a box C/D small nucleolar RNA." [GOC:mah] | 1 | 0.049891 | 98 |
Community 100
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-887-3p | hsa-mir-887-3p | hsa-mir-887-3p | 1 | 0.027114 | 100 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3585 | Cytosine methylation | Cytosine methylation | 1 | 0.04995 | 100 |
Community 101
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0010730 | Double eyebrow | This may present as a partial or complete duplication of the eyebrows. | 1 | 0.049962 | 101 |
Community 102
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M04057 | Factor: NFIB; motif: TTGGCANNNTGCCAR | Factor: NFIB; motif: TTGGCANNNTGCCAR | 1 | 0.049771 | 102 |
Community 104
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3596 | miR 517 relationship with ARCN1 and USP1 | miR 517 relationship with ARCN1 and USP1 | 1 | 0.031218 | 104 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0031673 | H zone | "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [GOC:mtg_muscle, ISBN:0321204131] | 1 | 0.041231 | 104 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0012822 | Bilateral vocal cord paresis | Decreased strength of the vocal fold on both sides. | 1 | 0.049962 | 104 |
Community 105
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M01830 | Factor: MAX; motif: CNNGMCACGTGN | Factor: MAX; motif: CNNGMCACGTGN | 2 | 0.013526 | 105 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1905202 | methylcrotonoyl-CoA carboxylase complex | "A protein complex capable of methylcrotonoyl-CoA carboxylase activity. In mammals, it is a mitochondrial complex comprising a dodecamer of 6 alpha and 6 beta subunits: MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation; MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:bf, GOC:hjd, GOC:PARL, PMID:15868465, PMID:17360195, PMID:22158123, PMID:22869039] | 1 | 0.041231 | 105 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004075 | biotin carboxylase activity | "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] | 1 | 0.049891 | 105 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7190 | 3-methylcrotonyl-CoA carboxylase | 3-methylcrotonyl-CoA carboxylase | 1 | 0.049932 | 105 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:4000206 | Reduced 3-methylcrotonyl CoA carboxylase activity in cultured fibroblasts | Activity of 3-methylcrotonyl-CoA carboxylase (EC 6.4.1.4) below the lower limit of normal in cultured fibroblasts. | 1 | 0.049962 | 105 |
Community 107
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990660 | calprotectin complex | "A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways." [GOC:bhm, PMID:25417112] | 1 | 0.041231 | 107 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6826 | Calprotectin heterotetramer | Calprotectin heterotetramer | 1 | 0.049932 | 107 |
Community 109
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00524 | Neomycin, kanamycin and gentamicin biosynthesis | Neomycin, kanamycin and gentamicin biosynthesis | 1 | 0.031175 | 109 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0008959 | Distal upper limb muscle weakness | Reduced strength of the distal musculature of the arms. | 2 | 0.042597 | 109 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047931 | glucosamine kinase activity | "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H+." [RHEA:10948] | 1 | 0.049891 | 109 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6432 | TTN-TCAP complex | TTN-TCAP complex | 1 | 0.049932 | 109 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-5619056 | Defective HK1 causes hexokinase deficiency (HK deficiency) | Defective HK1 causes hexokinase deficiency (HK deficiency) | 1 | 0.049932 | 109 |
Community 110
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006984 | ER-nucleus signaling pathway | "The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation." [GOC:mah] | 2 | 0.002547 | 110 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-574-3p | hsa-mir-574-3p | hsa-mir-574-3p | 2 | 0.009785 | 110 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0014801 | longitudinal sarcoplasmic reticulum | "The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae." [GOC:mtg_muscle] | 1 | 0.041231 | 110 |
| GO:CC | GO:0090534 | calcium ion-transporting ATPase complex | "Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in)." [GOC:BHF] | 1 | 0.041231 | 110 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0086039 | P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential | "A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 1 | 0.049891 | 110 |
Community 111
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0045344 | negative regulation of MHC class I biosynthetic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] | 1 | 0.049542 | 111 |
Community 113
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0019255 | glucose 1-phosphate metabolic process | "The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1." [GOC:ai] | 1 | 0.049542 | 113 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003983 | UTP:glucose-1-phosphate uridylyltransferase activity | "Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [EC:2.7.7.9, RHEA:19889] | 1 | 0.049891 | 113 |
| GO:MF | GO:0051748 | UTP-monosaccharide-1-phosphate uridylyltransferase activity | "Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide." [EC:2.7.7.64, PMID:15326166] | 1 | 0.049891 | 113 |
Community 114
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0005093 | Rab GDP-dissociation inhibitor activity | "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [GOC:mah] | 1 | 0.049891 | 114 |
Community 115
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0110031 | negative regulation of G2/MI transition of meiotic cell cycle | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw, PMID:25492408] | 1 | 0.049542 | 115 |
Community 116
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00400 | Phenylalanine, tyrosine and tryptophan biosynthesis | Phenylalanine, tyrosine and tryptophan biosynthesis | 1 | 0.011518 | 116 |
| KEGG | KEGG:00360 | Phenylalanine metabolism | Phenylalanine metabolism | 1 | 0.030715 | 116 |
| KEGG | KEGG:00220 | Arginine biosynthesis | Arginine biosynthesis | 1 | 0.042233 | 116 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4315 | Malate aspartate shuttle | Malate aspartate shuttle | 1 | 0.039736 | 116 |
| WP | WP:WP5507 | Mitochondrial carrier deficiency associated with shuttle disturbances | Mitochondrial carrier deficiency associated with shuttle disturbances | 1 | 0.049667 | 116 |
Community 119
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0036140 | [protein]-asparagine 3-dioxygenase activity | "Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2." [GOC:reh, PMID:12215170, RHEA:54260] | 1 | 0.049891 | 119 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP3593 | MicroRNA for targeting cancer growth and vascularization in glioblastoma | MicroRNA for targeting cancer growth and vascularization in glioblastoma | 1 | 0.04995 | 119 |
Community 122
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030906 | retromer, cargo-selective complex | "The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals." [GOC:bf, PMID:11102511, PMID:26220253, PMID:9700157] | 1 | 0.039955 | 122 |
Community 123
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1902104 | positive regulation of metaphase/anaphase transition of meiotic cell cycle | "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] | 1 | 0.049542 | 123 |
| GO:BP | GO:1905134 | positive regulation of meiotic chromosome separation | "Any process that activates or increases the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645] | 1 | 0.049542 | 123 |
| GO:BP | GO:1905186 | regulation of metaphase/anaphase transition of meiosis I | "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] | 1 | 0.049542 | 123 |
| GO:BP | GO:1905188 | positive regulation of metaphase/anaphase transition of meiosis I | "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] | 1 | 0.049542 | 123 |
Community 128
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006633 | fatty acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] | 2 | 0.029598 | 128 |
| GO:BP | GO:0061433 | cellular response to caloric restriction | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake." [GOC:dph, PMID:17914901] | 1 | 0.049542 | 128 |
| GO:BP | GO:0070446 | negative regulation of oligodendrocyte progenitor proliferation | "Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] | 1 | 0.049542 | 128 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0030389 | Abnormal circulating thromboxane concentration | Any deviation from the normal concentration in the blood circulation of a thromboxane. Thromboxanes are derived from prostaglandin precursors in platelets, and stimulate aggregation of platelets and constriction of blood vessels. | 1 | 0.049962 | 128 |
| HP | HP:0032244 | Decreased serum thromboxane B2 | A reduction in the concentration of thromboxane B2 in the blood circulation. | 1 | 0.049962 | 128 |
| HP | HP:0032575 | Decreased circulating 12-HETE | A reduction in the concentration of 12-HETE in the blood circulation, a metabolite of arachidonic acid. | 1 | 0.049962 | 128 |
Community 129
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004725 | protein tyrosine phosphatase activity | "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] | 2 | 0.013199 | 129 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006470 | protein dephosphorylation | "The process of removing one or more phosphoric residues from a protein." [GOC:hb] | 2 | 0.024261 | 129 |
Community 132
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0048257 | 3'-flap endonuclease activity | "Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid, PMID:10635319] | 1 | 0.049891 | 132 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:13 | MUS81-CDS1 complex | MUS81-CDS1 complex | 1 | 0.049932 | 132 |
Community 133
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0002945 | cyclin K-CDK13 complex | "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] | 1 | 0.041231 | 133 |
Community 134
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11042 | Factor: HMBOX1; motif: NCTAGTTAN | Factor: HMBOX1; motif: NCTAGTTAN | 2 | 0.020772 | 134 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0016261 | selenocysteine catabolic process | "The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732] | 1 | 0.049542 | 134 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0009000 | selenocysteine lyase activity | "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor." [EC:4.4.1.16] | 1 | 0.049891 | 134 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0410262 | Lower cranial nerve dysfunction | A functional abnormality affecting the lower cranial nerves, which include the paired 9th (glossopharyngeal), 10th (vagal), 11th (accessory) and 12th (hypoglossal) cranial nerves. | 1 | 0.049962 | 134 |
Community 136
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-29a-3p | hsa-mir-29a-3p | hsa-mir-29a-3p | 2 | 0.028666 | 136 |
Community 139
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:2000720 | positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric | "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah] | 1 | 0.049542 | 139 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1851 | BUB1-BUB3 complex | BUB1-BUB3 complex | 1 | 0.049932 | 139 |
Community 141
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0040167 | Facial papilloma | Facial papilloma | 1 | 0.049962 | 141 |
Community 142
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0071621 | granulocyte chemotaxis | "The movement of a granulocyte in response to an external stimulus." [GOC:rph] | 2 | 0.019454 | 142 |
| GO:BP | GO:0097530 | granulocyte migration | "The movement of a granulocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:24163421, PMID:24193336] | 2 | 0.028856 | 142 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5843 | AIF-CYPA-DNA complex | AIF-CYPA-DNA complex | 1 | 0.049932 | 142 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-164516 | Minus-strand DNA synthesis | Minus-strand DNA synthesis | 1 | 0.049932 | 142 |
| REAC | REAC:R-HSA-164525 | Plus-strand DNA synthesis | Plus-strand DNA synthesis | 1 | 0.049932 | 142 |
| REAC | REAC:R-HSA-162589 | Reverse Transcription of HIV RNA | Reverse Transcription of HIV RNA | 1 | 0.049932 | 142 |
| REAC | REAC:R-HSA-162585 | Uncoating of the HIV Virion | Uncoating of the HIV Virion | 1 | 0.049932 | 142 |
Community 143
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:2000331 | regulation of terminal button organization | "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah] | 1 | 0.049542 | 143 |
Community 145
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1028 | HNF4A-SUB1 complex | HNF4A-SUB1 complex | 1 | 0.049932 | 145 |
Community 146
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004725 | protein tyrosine phosphatase activity | "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] | 2 | 0.013199 | 146 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006470 | protein dephosphorylation | "The process of removing one or more phosphoric residues from a protein." [GOC:hb] | 2 | 0.024261 | 146 |
Community 147
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030658 | transport vesicle membrane | "The lipid bilayer surrounding a transport vesicle." [GOC:mah] | 2 | 0.029673 | 147 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051650 | establishment of vesicle localization | "The directed movement of a vesicle to a specific location." [GOC:ai] | 2 | 0.046891 | 147 |
| GO:BP | GO:0106272 | protein localization to ERGIC | "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum-Golgi intermediate compartment (ERGIC)." [PMID:32272059] | 1 | 0.049542 | 147 |
| GO:BP | GO:0106273 | cytosol to ERGIC protein transport | "The directed movement of proteins from the cystosol to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC)." [PMID:32272059] | 1 | 0.049542 | 147 |
Community 148
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6783 | CLIC5A-EZR-PODXL complex | CLIC5A-EZR-PODXL complex | 1 | 0.049932 | 148 |
Community 149
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003937 | IMP cyclohydrolase activity | "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10] | 1 | 0.049891 | 149 |
| GO:MF | GO:0004643 | phosphoribosylaminoimidazolecarboxamide formyltransferase activity | "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3] | 1 | 0.049891 | 149 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034565 | Elevated urinary 5-amino-4-imidazolecarboxamide-riboside level | Increased amount of 5-amino-4-imidazolecarboxamide(AICA)-riboside in the urine. AICA-riboside is the dephosphorylated counterpart of AICAR, an intermediate of de novo purine biosynthesis. | 1 | 0.049962 | 149 |
| HP | HP:6000752 | Elevated erythrocyte AICA-ribotide concentration | Concentration of 5-amino-4-imidazolecarboxamide (AICA-riboside) in red blood cells is above the upper limit of normal. | 1 | 0.049962 | 149 |
Community 150
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0086098 | angiotensin-activated signaling pathway involved in heart process | "An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402] | 1 | 0.049542 | 150 |
Community 151
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5467 | IKB(alpha)-RELA-cREL complex | IKB(alpha)-RELA-cREL complex | 1 | 0.049932 | 151 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0031380 | Abnormal B cell proliferation | Any abnormality in the multiplication or reproduction of B cells, which results in the expansion of a cell population. | 1 | 0.049962 | 151 |
Community 152
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0098798 | mitochondrial protein-containing complex | "A protein complex that is part of a mitochondrion." [GOC:dos] | 2 | 0.015501 | 152 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007006 | mitochondrial membrane organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 2 | 0.015717 | 152 |
Community 153
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0091073 | Cerebellum; white matter cells - cytoplasm/membrane[High] | Cerebellum; white matter cells - cytoplasm/membrane[High] | 2 | 0.007612 | 153 |
| HPA | HPA:0090973 | Cerebellum; granular cells - cytoplasm/membrane[High] | Cerebellum; granular cells - cytoplasm/membrane[High] | 2 | 0.008951 | 153 |
| HPA | HPA:0091072 | Cerebellum; white matter cells - cytoplasm/membrane[≥Medium] | Cerebellum; white matter cells - cytoplasm/membrane[≥Medium] | 2 | 0.026597 | 153 |
| HPA | HPA:0090972 | Cerebellum; granular cells - cytoplasm/membrane[≥Medium] | Cerebellum; granular cells - cytoplasm/membrane[≥Medium] | 2 | 0.028305 | 153 |
| HPA | HPA:0091071 | Cerebellum; white matter cells - cytoplasm/membrane[≥Low] | Cerebellum; white matter cells - cytoplasm/membrane[≥Low] | 2 | 0.044498 | 153 |
| HPA | HPA:0090971 | Cerebellum; granular cells - cytoplasm/membrane[≥Low] | Cerebellum; granular cells - cytoplasm/membrane[≥Low] | 2 | 0.047018 | 153 |
| HPA | HPA:0091002 | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium] | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium] | 2 | 0.049936 | 153 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:rno-mir-9a-5p | rno-mir-9a-5p | rno-mir-9a-5p | 1 | 0.018269 | 153 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0030379 | neurotensin receptor activity, non-G protein-coupled | "Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins." [GOC:mah, GOC:signaling, PMID:9756851] | 1 | 0.049891 | 153 |
Community 154
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP134 | Pentose phosphate metabolism | Pentose phosphate metabolism | 2 | 0.000024 | 154 |
| WP | WP:WP5043 | Pentose phosphate pathway in senescent cells | Pentose phosphate pathway in senescent cells | 2 | 0.000032 | 154 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0009052 | pentose-phosphate shunt, non-oxidative branch | "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY] | 2 | 0.000035 | 154 |
| GO:BP | GO:0019682 | glyceraldehyde-3-phosphate metabolic process | "The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai, ISBN:0198506732] | 2 | 0.000156 | 154 |
| GO:BP | GO:0006098 | pentose-phosphate shunt | "The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY] | 2 | 0.000448 | 154 |
| GO:BP | GO:0006740 | NADPH regeneration | "A metabolic process that generates a pool of NADPH by the reduction of NADP+." [GOC:mah] | 2 | 0.000596 | 154 |
| GO:BP | GO:0051156 | glucose 6-phosphate metabolic process | "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] | 2 | 0.000957 | 154 |
| GO:BP | GO:0006739 | NADP metabolic process | "The chemical reactions and pathways involving nicotinamide adenine dinucleotide phosphate (NADP+), a coenzyme that interconverts with its reduced form, NADPH, in many redox and biosynthetic reactions." [GOC:mah] | 2 | 0.001932 | 154 |
| GO:BP | GO:0006081 | aldehyde metabolic process | "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732] | 2 | 0.006716 | 154 |
| GO:BP | GO:0019362 | pyridine nucleotide metabolic process | "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] | 2 | 0.030729 | 154 |
| GO:BP | GO:0046496 | nicotinamide nucleotide metabolic process | "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] | 2 | 0.030729 | 154 |
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 2 | 0.033450 | 154 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00030 | Pentose phosphate pathway | Pentose phosphate pathway | 2 | 0.000342 | 154 |
| KEGG | KEGG:01230 | Biosynthesis of amino acids | Biosynthesis of amino acids | 2 | 0.001986 | 154 |
| KEGG | KEGG:01200 | Carbon metabolism | Carbon metabolism | 2 | 0.004819 | 154 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-71336 | Pentose phosphate pathway | Pentose phosphate pathway | 2 | 0.000476 | 154 |
| REAC | REAC:R-HSA-6791462 | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | 1 | 0.049932 | 154 |
| REAC | REAC:R-HSA-6791055 | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | 1 | 0.049932 | 154 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004801 | transaldolase activity | "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [PMID:7592346, RHEA:17053] | 1 | 0.049891 | 154 |
Community 155
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4238 | Flavan 3 ol metabolic pathway | Flavan 3 ol metabolic pathway | 1 | 0.009936 | 155 |
| WP | WP:WP5316 | Primary ovarian insufficiency | Primary ovarian insufficiency | 2 | 0.016892 | 155 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0051908 | double-stranded DNA 5'-3' DNA exonuclease activity | "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule." [GOC:ai] | 1 | 0.049891 | 155 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:424 | EXO1-MLH1-PCNA complex | EXO1-MLH1-PCNA complex | 1 | 0.049932 | 155 |
Community 156
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047620 | acylglycerol kinase activity | "Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate." [EC:2.7.1.94, MetaCyc:ACYLGLYCEROL-KINASE-RXN] | 1 | 0.049891 | 156 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2308 | AP3D1-AP3S1 complex | AP3D1-AP3S1 complex | 1 | 0.049932 | 156 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0004901 | Exercise-induced lactic acidemia | A form of lactic acidemia that occurs following exercise or exertion. | 1 | 0.049962 | 156 |
Community 157
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4685 | Melanoma | Melanoma | 2 | 0.002586 | 157 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 2 | 0.007098 | 157 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 2 | 0.015671 | 157 |
| GO:CC | GO:0061826 | podosome ring | "The ring structure surrounding the podosome core, containing proteins such as vinculin and talin." [PMID:23158496] | 1 | 0.020616 | 157 |
| GO:CC | GO:0090636 | outer dense plaque of desmosome | "The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins, as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane." [PMID:20066089] | 1 | 0.020616 | 157 |
| GO:CC | GO:0090637 | inner dense plaque of desmosome | "The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane." [PMID:20066089] | 1 | 0.020616 | 157 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1904702 | regulation of protein localization to adherens junction | "Any process that modulates the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237] | 1 | 0.049542 | 157 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0034313 | Hyperdynamic left ventricular ejection fraction | An abnormally increased ejection fraction of the left ventricle, usually defined as a left ventricular ejection fraction greater than 70 percent. | 1 | 0.049962 | 157 |
Community 159
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6208 | PNP homotrimer complex | PNP homotrimer complex | 1 | 0.024966 | 159 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006738 | nicotinamide riboside catabolic process | "The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732] | 1 | 0.049542 | 159 |
| GO:BP | GO:0010625 | positive regulation of Schwann cell proliferation | "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] | 1 | 0.049542 | 159 |
| GO:BP | GO:0046495 | nicotinamide riboside metabolic process | "The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732] | 1 | 0.049542 | 159 |
| GO:BP | GO:0070637 | pyridine nucleoside metabolic process | "The chemical reactions and pathways involving any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [GOC:mah] | 1 | 0.049542 | 159 |
| GO:BP | GO:0070638 | pyridine nucleoside catabolic process | "The chemical reactions and pathways resulting in the breakdown of any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [GOC:mah] | 1 | 0.049542 | 159 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-9735763 | Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine | Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine | 1 | 0.049932 | 159 |
| REAC | REAC:R-HSA-9735786 | Nucleotide catabolism defects | Nucleotide catabolism defects | 1 | 0.049932 | 159 |
Community 164
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6886-5p | hsa-mir-6886-5p | hsa-mir-6886-5p | 1 | 0.036152 | 164 |
Community 166
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05523_1 | Factor: ZBTB46; motif: NGGGGGATAGN; match class: 1 | Factor: ZBTB46; motif: NGGGGGATAGN; match class: 1 | 1 | 0.012443 | 166 |
Community 167
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990674 | Golgi cis cisterna membrane | "The lipid bilayer surrounding any of the thin, flattened compartments that form the cis portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662] | 1 | 0.029966 | 167 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6841-5p | hsa-mir-6841-5p | hsa-mir-6841-5p | 1 | 0.040671 | 167 |
Community 168
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-5707 | hsa-mir-5707 | hsa-mir-5707 | 1 | 0.036152 | 168 |
Community 170
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12459_1 | Factor: TCF12; motif: NNCACCTGCNN; match class: 1 | Factor: TCF12; motif: NNCACCTGCNN; match class: 1 | 1 | 0.024886 | 170 |
Community 173
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12336 | Factor: BCL-6B; motif: NCGTAATCTAGGAATN | Factor: BCL-6B; motif: NCGTAATCTAGGAATN | 1 | 0.012443 | 173 |
Community 174
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0032798 | Swi5-Sfr1 complex | "A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces)." [PMID:15620352, PMID:16921379] | 1 | 0.009989 | 174 |
Community 175
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471383 | Skin 2; arrector pili muscle cells[High] | Skin 2; arrector pili muscle cells[High] | 1 | 0.034172 | 175 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0034443 | negative regulation of lipoprotein oxidation | "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah] | 1 | 0.049542 | 175 |
| GO:BP | GO:0060588 | negative regulation of lipoprotein lipid oxidation | "Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:dph, GOC:tb] | 1 | 0.049542 | 175 |
Community 179
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:3151 | Sulphiredoxin-peroxiredoxin complex | Sulphiredoxin-peroxiredoxin complex | 1 | 0.049932 | 179 |
| CORUM | CORUM:6675 | PI4K2A-PRDX1 complex | PI4K2A-PRDX1 complex | 1 | 0.049932 | 179 |
Community 184
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6080 | hsa-mir-6080 | hsa-mir-6080 | 1 | 0.04971 | 184 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:518 | AKAP250-PKA-PDE4D complex | AKAP250-PKA-PDE4D complex | 1 | 0.049932 | 184 |
Community 185
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004796 | thromboxane-A synthase activity | "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17137] | 1 | 0.049891 | 185 |
Community 186
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M08258_1 | Factor: ER71:FOXI1; motif: TGTTKACGGAAGTN; match class: 1 | Factor: ER71:FOXI1; motif: TGTTKACGGAAGTN; match class: 1 | 1 | 0.049771 | 186 |
Community 187
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:1901707 | leptomycin B binding | "Binding to leptomycin B." [GOC:TermGenie] | 1 | 0.024946 | 187 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0072750 | cellular response to leptomycin B | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:mah] | 1 | 0.049542 | 187 |
| GO:BP | GO:1901344 | response to leptomycin B | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:TermGenie] | 1 | 0.049542 | 187 |
Community 189
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0030479 | actin cortical patch | "An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae." [GOC:mah, GOC:vw, ISBN:0879693568, ISBN:0879693649, PMID:16959963] | 1 | 0.049943 | 189 |
| GO:CC | GO:0061645 | endocytic patch | "The part of the cell cortex consisting of an aggregation of proteins that will give rise to an endocytic vesicle." [GOC:dph, PMID:22949647] | 1 | 0.049943 | 189 |
Community 190
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990917 | ooplasm | "The cytoplasm of an ovum." [PMID:19022436] | 1 | 0.019977 | 190 |
Community 191
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03450 | Non-homologous end-joining | Non-homologous end-joining | 1 | 0.024956 | 191 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7282 | FEN1-WRN complex | FEN1-WRN complex | 1 | 0.049932 | 191 |
Community 196
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-891a-5p | hsa-mir-891a-5p | hsa-mir-891a-5p | 1 | 0.027114 | 196 |
Community 197
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06304 | Factor: ZNF260; motif: YTAAMCGGGAATACCTA | Factor: ZNF260; motif: YTAAMCGGGAATACCTA | 1 | 0.012443 | 197 |
Community 199
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0099160 | postsynaptic intermediate filament cytoskeleton | "The intermediate filament cytoskeleton that is part of a postsynapse." [GOC:dos, PMID:25869803] | 1 | 0.039955 | 199 |
| GO:CC | GO:0097418 | neurofibrillary tangle | "Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star." [NIF_Subcellular:nlx_subcell_20090201, NIF_Subcellular:nlx_subcell_20090202, NIF_Subcellular:sao2409833926] | 1 | 0.049943 | 199 |
Community 200
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03450 | Non-homologous end-joining | Non-homologous end-joining | 1 | 0.024956 | 200 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12446_1 | Factor: BHLHE22; motif: NNCAGCTGNN; match class: 1 | Factor: BHLHE22; motif: NNCAGCTGNN; match class: 1 | 1 | 0.049771 | 200 |
Community 201
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1905202 | methylcrotonoyl-CoA carboxylase complex | "A protein complex capable of methylcrotonoyl-CoA carboxylase activity. In mammals, it is a mitochondrial complex comprising a dodecamer of 6 alpha and 6 beta subunits: MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation; MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:bf, GOC:hjd, GOC:PARL, PMID:15868465, PMID:17360195, PMID:22158123, PMID:22869039] | 1 | 0.019977 | 201 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004485 | methylcrotonoyl-CoA carboxylase activity | "Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate." [EC:6.4.1.4, RHEA:13589] | 1 | 0.049891 | 201 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7190 | 3-methylcrotonyl-CoA carboxylase | 3-methylcrotonyl-CoA carboxylase | 1 | 0.049932 | 201 |
Community 202
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:7224 | HCF1-THAP11 complex | HCF1-THAP11 complex | 1 | 0.049932 | 202 |
| CORUM | CORUM:7260 | HCFC1-THAP11 subcomplex | HCFC1-THAP11 subcomplex | 1 | 0.049932 | 202 |
Community 204
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004122 | cystathionine beta-synthase activity | "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22] | 1 | 0.024946 | 204 |
| GO:MF | GO:0070025 | carbon monoxide binding | "Binding to carbon monoxide (CO)." [GOC:ecd] | 1 | 0.049891 | 204 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1614603 | Cysteine formation from homocysteine | Cysteine formation from homocysteine | 1 | 0.024966 | 204 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006535 | cysteine biosynthetic process from serine | "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators] | 1 | 0.049542 | 204 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0032352 | Methioninuria | Level of methionine in urine above the upper limit of normal. | 1 | 0.049962 | 204 |
| HP | HP:0033724 | Cerebral venous sinus thrombosis | An intracranial thrombosis of the venous sinuses. These typically present with headache, seizures or venous stroke secondary to raised cerebral venous pressure. Cerebral venous sinus thromboses usually affect larger areas of brain parenchyma than those affected by cerebral vein thromboses. | 1 | 0.049962 | 204 |
| HP | HP:6000357 | Reduced cystathionine beta-synthase activity in cultured fibroblasts | Activity of cystathionine beta-synthase (EC 4.2.1.22) below the lower limit of normal in cultured fibroblasts. | 1 | 0.049962 | 204 |
Community 206
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0019118 | phenanthrene-epoxide hydrolase activity | "Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0535, UM-BBD_reactionID:r0536] | 1 | 0.024946 | 206 |
| GO:MF | GO:0019119 | phenanthrene-9,10-epoxide hydrolase activity | "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0496, UM-BBD_reactionID:r0560] | 1 | 0.024946 | 206 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP699 | Aflatoxin B1 metabolism | Aflatoxin B1 metabolism | 1 | 0.043706 | 206 |
Community 208
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0002944 | cyclin K-CDK12 complex | "A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] | 1 | 0.019977 | 208 |
| GO:CC | GO:0002945 | cyclin K-CDK13 complex | "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] | 1 | 0.019977 | 208 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1083 | P-TEFb.4 complex | P-TEFb.4 complex | 1 | 0.049932 | 208 |
Community 209
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0031416 | NatB complex | "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471] | 1 | 0.019977 | 209 |
Community 212
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:mir-322-5p | mir-322-5p | mir-322-5p | 1 | 0.00226 | 212 |
Community 213
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0034967 | Set3 complex | "A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p." [GOC:ds, PMID:11711434] | 1 | 0.019977 | 213 |
| GO:CC | GO:0070210 | Rpd3L-Expanded complex | "A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720] | 1 | 0.019977 | 213 |
Community 215
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:1990713 | survivin complex | "A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC)." [GOC:bhm, PMID:10949038] | 1 | 0.009989 | 215 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2580 | Survivin homodimer complex | Survivin homodimer complex | 1 | 0.024966 | 215 |
| CORUM | CORUM:1117 | CRM1-Survivin mitotic complex | CRM1-Survivin mitotic complex | 1 | 0.049932 | 215 |
| CORUM | CORUM:2581 | RasGAP-AURKA-survivin complex | RasGAP-AURKA-survivin complex | 1 | 0.049932 | 215 |
| CORUM | CORUM:6756 | RasGAP-AURKB-survivin complex | RasGAP-AURKB-survivin complex | 1 | 0.049932 | 215 |
Community 216
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6786-5p | hsa-mir-6786-5p | hsa-mir-6786-5p | 1 | 0.031633 | 216 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0009555 | Hypoplasia of the pharynx | Underdevelopment of the pharynx. | 1 | 0.049962 | 216 |
| HP | HP:6000612 | Squamosal suture synostosis | Premature closure of the squamosal suture, which is one of the lateral minor skull sutures, separating the parietal and squamous temporal bones. | 1 | 0.049962 | 216 |
Community 218
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0032034 | myosin II head/neck binding | "Binding to the head/neck region of a myosin II heavy chain." [GOC:mah] | 1 | 0.024946 | 218 |
| GO:MF | GO:0032028 | myosin head/neck binding | "Binding to the head/neck region of a myosin heavy chain." [GOC:mah] | 1 | 0.049891 | 218 |
Community 219
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06763 | Factor: ZNF225; motif: NGGGWAAAMCGN | Factor: ZNF225; motif: NGGGWAAAMCGN | 1 | 0.049771 | 219 |
Community 223
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005854 | nascent polypeptide-associated complex | "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149] | 1 | 0.039955 | 223 |
Community 225
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6727-5p | hsa-mir-6727-5p | hsa-mir-6727-5p | 1 | 0.033893 | 225 |
Community 226
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6881-5p | hsa-mir-6881-5p | hsa-mir-6881-5p | 1 | 0.04971 | 226 |
Community 227
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0086060 | voltage-gated sodium channel activity involved in AV node cell action potential | "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 1 | 0.024946 | 227 |
| GO:MF | GO:0086061 | voltage-gated sodium channel activity involved in bundle of His cell action potential | "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 1 | 0.024946 | 227 |
| GO:MF | GO:0086062 | voltage-gated sodium channel activity involved in Purkinje myocyte action potential | "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 1 | 0.024946 | 227 |
| GO:MF | GO:0086063 | voltage-gated sodium channel activity involved in SA node cell action potential | "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] | 1 | 0.024946 | 227 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6096 | alphaB-crystallin-Nav1.5 complex | alphaB-crystallin-Nav1.5 complex | 1 | 0.049932 | 227 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0005170 | Complete heart block with broad QRS complexes | A type of third degree heart block in which the escape rhythm arises at a relatively low part of the conduction system (below the atrioventricular node), which produces a wide QRS complex. | 1 | 0.049962 | 227 |
| HP | HP:0005172 | Left posterior fascicular block | Conduction block in the posterior division of the left bundle branch of the bundle of His. | 1 | 0.049962 | 227 |
| HP | HP:0011841 | Ventricular flutter | A potentially lethal cardiac arrhythmia characterized by an extremely rapid, hemodynamically unstable ventricular tachycardia (150-300 beats/min) with a large oscillating sine-wave appearance. | 1 | 0.049962 | 227 |
Community 229
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6080 | hsa-mir-6080 | hsa-mir-6080 | 1 | 0.04971 | 229 |
Community 232
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-8985801 | Regulation of cortical dendrite branching | Regulation of cortical dendrite branching | 1 | 0.049932 | 232 |
| REAC | REAC:R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | SLIT2:ROBO1 increases RHOA activity | 1 | 0.049932 | 232 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011679 | Tetralogy of Fallot with pulmonary stenosis | The commonest form of tetralogy of Fallot characterized by pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy, without pulmonary atresia, absent pulmonary valve, atrioventricular canal defect or absent subarterial conus. | 1 | 0.049962 | 232 |
| HP | HP:0034976 | Absent pituitary stalk | A developmental defect characterized by failure to develop of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland. | 1 | 0.049962 | 232 |
| HP | HP:0034977 | Abnormal pituitary stalk morphology | A structural anomaly of the pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland. | 1 | 0.049962 | 232 |
| HP | HP:0034978 | Interrupted pituitary stalk | A developmental defect characterized by a discontinuity of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland. | 1 | 0.049962 | 232 |
Community 234
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6212 | GM130-GRASP65 complex | GM130-GRASP65 complex | 1 | 0.049932 | 234 |
Community 239
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0411242 | Retina; inner plexiform layer[≥Medium] | Retina; inner plexiform layer[≥Medium] | 1 | 0.047315 | 239 |
| HPA | HPA:0411253 | Retina; nerve fiber layer[High] | Retina; nerve fiber layer[High] | 1 | 0.047315 | 239 |
Community 240
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0050346 | trans-L-3-hydroxyproline dehydratase activity | "Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H2O + H+." [EC:4.2.1.77, RHEA:10320] | 1 | 0.024946 | 240 |
Community 242
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6743-3p | hsa-mir-6743-3p | hsa-mir-6743-3p | 1 | 0.040671 | 242 |
Community 243
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000417 | HIR complex | "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700] | 1 | 0.009989 | 243 |
Community 247
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0003359 | noradrenergic neuron fate commitment | "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph] | 1 | 0.049542 | 247 |
| GO:BP | GO:0007400 | neuroblast fate determination | "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators] | 1 | 0.049542 | 247 |
| GO:BP | GO:0014017 | neuroblast fate commitment | "The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585] | 1 | 0.049542 | 247 |
| GO:BP | GO:0060165 | regulation of timing of subpallium neuron differentiation | "The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon." [GOC:dph] | 1 | 0.049542 | 247 |
| GO:BP | GO:0061100 | lung neuroendocrine cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium." [GOC:dph, PMID:9126746] | 1 | 0.049542 | 247 |
| GO:BP | GO:0061103 | carotid body glomus cell differentiation | "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia." [GOC:dph, PMID:6243386] | 1 | 0.049542 | 247 |
| GO:BP | GO:0071259 | cellular response to magnetism | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:mah] | 1 | 0.049542 | 247 |
Community 251
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0020033 | Adrenal gland; cells in zona glomerulosa[High] | Adrenal gland; cells in zona glomerulosa[High] | 1 | 0.049944 | 251 |
Community 253
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000938 | GARP complex | "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664] | 1 | 0.049943 | 253 |
| GO:CC | GO:1990745 | EARP complex | "A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061] | 1 | 0.049943 | 253 |
Community 255
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0098892 | extrinsic component of postsynaptic specialization membrane | "The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] | 1 | 0.049943 | 255 |
| GO:CC | GO:0099147 | extrinsic component of postsynaptic density membrane | "The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] | 1 | 0.049943 | 255 |
Community 256
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047453 | ATP-dependent NAD(P)H-hydrate dehydratase activity | "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + H+ + NAD(P)H + phosphate." [EC:4.2.1.93, PMID:3061454] | 1 | 0.024946 | 256 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP5506 | Disorders of NAD metabolism | Disorders of NAD metabolism | 1 | 0.031218 | 256 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0110051 | metabolite repair | "A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites." [GOC:ka, PMID:23334546, PMID:28373563] | 1 | 0.049542 | 256 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06825 | Factor: ZNF96; motif: NWAGKTSACKARGACCGN | Factor: ZNF96; motif: NWAGKTSACKARGACCGN | 1 | 0.049771 | 256 |
washu+biogrid+hippie (Louvain)
Community 0
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 191 | 1.285436e-83 | 0 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 195 | 2.928410e-67 | 0 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 125 | 4.687908e-61 | 0 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 195 | 1.132077e-52 | 0 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 195 | 1.132077e-52 | 0 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 195 | 1.132077e-52 | 0 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 222 | 7.103626e-45 | 0 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 31 | 3.778991e-40 | 0 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 37 | 6.014747e-38 | 0 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 71 | 3.556974e-37 | 0 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 176 | 4.331813e-37 | 0 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 176 | 4.428150e-37 | 0 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 37 | 3.114856e-36 | 0 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 46 | 2.312313e-34 | 0 |
| GO:CC | GO:0000785 | chromatin | "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] | 76 | 3.110099e-29 | 0 |
| GO:CC | GO:0000228 | nuclear chromosome | "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] | 37 | 6.509987e-29 | 0 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 48 | 3.970994e-27 | 0 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 82 | 4.803540e-27 | 0 |
| GO:CC | GO:0098687 | chromosomal region | "Any subdivision of a chromosome along its length." [GOC:dos] | 43 | 1.104204e-26 | 0 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 232 | 7.808239e-21 | 0 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 164 | 3.711091e-19 | 0 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 88 | 5.628317e-19 | 0 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 239 | 1.338326e-18 | 0 |
| GO:CC | GO:0000781 | chromosome, telomeric region | "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] | 25 | 3.848976e-18 | 0 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 61 | 3.062597e-17 | 0 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 43 | 3.739394e-16 | 0 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 233 | 9.922330e-16 | 0 |
| GO:CC | GO:0005815 | microtubule organizing center | "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] | 46 | 1.187372e-15 | 0 |
| GO:CC | GO:0005657 | replication fork | "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] | 17 | 2.956298e-15 | 0 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 240 | 4.106725e-15 | 0 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 26 | 6.917303e-15 | 0 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 46 | 1.486239e-14 | 0 |
| GO:CC | GO:0032993 | protein-DNA complex | "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] | 25 | 1.972008e-14 | 0 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 119 | 2.657605e-12 | 0 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 242 | 1.542954e-11 | 0 |
| GO:CC | GO:0000793 | condensed chromosome | "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] | 23 | 7.606718e-11 | 0 |
| GO:CC | GO:0043596 | nuclear replication fork | "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] | 11 | 2.804580e-10 | 0 |
| GO:CC | GO:0000775 | chromosome, centromeric region | "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] | 20 | 8.924490e-09 | 0 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 65 | 1.696798e-08 | 0 |
| GO:CC | GO:0005819 | spindle | "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] | 24 | 8.130232e-08 | 0 |
| GO:CC | GO:0000123 | histone acetyltransferase complex | "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] | 12 | 2.111002e-07 | 0 |
| GO:CC | GO:0070533 | BRCA1-C complex | "A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint." [GOC:mah, PMID:15485915, PMID:16391231] | 5 | 4.120438e-07 | 0 |
| GO:CC | GO:0032806 | carboxy-terminal domain protein kinase complex | "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683] | 7 | 5.778991e-07 | 0 |
| GO:CC | GO:0031248 | protein acetyltransferase complex | "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf] | 12 | 7.115475e-07 | 0 |
| GO:CC | GO:1902493 | acetyltransferase complex | "A protein complex which is capable of acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 12 | 7.974008e-07 | 0 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 33 | 8.821373e-07 | 0 |
| GO:CC | GO:0016363 | nuclear matrix | "A dynamic, proteinaceous framework within the nucleus of eukaryotic cells, composed of proteins and RNA, that provides structural support for chromatin organization, gene regulation, and nuclear processes." [PMID:15608168, PMID:3058729, PMID:39789220] | 13 | 1.026513e-06 | 0 |
| GO:CC | GO:0072686 | mitotic spindle | "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] | 15 | 1.256862e-06 | 0 |
| GO:CC | GO:0030894 | replisome | "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] | 7 | 2.482623e-06 | 0 |
| GO:CC | GO:0000428 | DNA-directed RNA polymerase complex | "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] | 12 | 4.219644e-06 | 0 |
| GO:CC | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] | 7 | 4.628433e-06 | 0 |
| GO:CC | GO:0030880 | RNA polymerase complex | "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah] | 12 | 5.602688e-06 | 0 |
| GO:CC | GO:0000794 | condensed nuclear chromosome | "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh] | 10 | 1.158237e-05 | 0 |
| GO:CC | GO:0000792 | heterochromatin | "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] | 10 | 1.303965e-05 | 0 |
| GO:CC | GO:0000791 | euchromatin | "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156] | 9 | 1.625898e-05 | 0 |
| GO:CC | GO:0055029 | nuclear DNA-directed RNA polymerase complex | "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu] | 11 | 2.525680e-05 | 0 |
| GO:CC | GO:0071162 | CMG complex | "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417] | 5 | 3.029243e-05 | 0 |
| GO:CC | GO:0000439 | transcription factor TFIIH core complex | "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] | 5 | 3.029243e-05 | 0 |
| GO:CC | GO:0000776 | kinetochore | "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] | 13 | 3.536408e-05 | 0 |
| GO:CC | GO:0043073 | germ cell nucleus | "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators] | 9 | 4.104930e-05 | 0 |
| GO:CC | GO:0043601 | nuclear replisome | "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] | 6 | 4.916728e-05 | 0 |
| GO:CC | GO:0005675 | transcription factor TFIIH holo complex | "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] | 5 | 5.145175e-05 | 0 |
| GO:CC | GO:0000779 | condensed chromosome, centromeric region | "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] | 13 | 7.737218e-05 | 0 |
| GO:CC | GO:0031261 | DNA replication preinitiation complex | "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184] | 5 | 8.283946e-05 | 0 |
| GO:CC | GO:0017053 | transcription repressor complex | "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] | 9 | 1.048845e-04 | 0 |
| GO:CC | GO:0016605 | PML body | "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585] | 10 | 1.622236e-04 | 0 |
| GO:CC | GO:0005635 | nuclear envelope | "The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport." [ISBN:0198547684, PMID:16164970] | 21 | 2.009825e-04 | 0 |
| GO:CC | GO:0000922 | spindle pole | "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] | 12 | 4.026356e-04 | 0 |
| GO:CC | GO:0000152 | nuclear ubiquitin ligase complex | "A ubiquitin ligase complex found in the nucleus." [GOC:mah] | 7 | 4.845027e-04 | 0 |
| GO:CC | GO:0097134 | cyclin E1-CDK2 complex | "A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 3 | 5.594403e-04 | 0 |
| GO:CC | GO:0097124 | cyclin A2-CDK2 complex | "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 3 | 5.594403e-04 | 0 |
| GO:CC | GO:0042575 | DNA polymerase complex | "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, PMID:12045093] | 5 | 9.354376e-04 | 0 |
| GO:CC | GO:0000151 | ubiquitin ligase complex | "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] | 15 | 1.740126e-03 | 0 |
| GO:CC | GO:0042555 | MCM complex | "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] | 4 | 1.934459e-03 | 0 |
| GO:CC | GO:1990391 | DNA repair complex | "A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350] | 5 | 1.974785e-03 | 0 |
| GO:CC | GO:0070516 | CAK-ERCC2 complex | "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2." [PMID:8692841, PMID:8692842] | 3 | 2.219043e-03 | 0 |
| GO:CC | GO:0035189 | Rb-E2F complex | "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073] | 3 | 2.219043e-03 | 0 |
| GO:CC | GO:0005677 | chromatin silencing complex | "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] | 4 | 4.117351e-03 | 0 |
| GO:CC | GO:0031461 | cullin-RING ubiquitin ligase complex | "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] | 11 | 4.406260e-03 | 0 |
| GO:CC | GO:0005658 | alpha DNA polymerase:primase complex | "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a small stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402, PMID:26975377] | 3 | 5.501226e-03 | 0 |
| GO:CC | GO:0070418 | DNA-dependent protein kinase complex | "A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku." [GOC:mah, PMID:10854421, PMID:12235392] | 3 | 5.501226e-03 | 0 |
| GO:CC | GO:0016602 | CCAAT-binding factor complex | "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851] | 3 | 5.501226e-03 | 0 |
| GO:CC | GO:0035861 | site of double-strand break | "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] | 8 | 6.082610e-03 | 0 |
| GO:CC | GO:0090734 | site of DNA damage | "A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg] | 9 | 6.403530e-03 | 0 |
| GO:CC | GO:0005721 | pericentric heterochromatin | "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3)." [PMID:12019236, PMID:20206496, PMID:21437270, PMID:22729156, PMID:9413993] | 5 | 9.262946e-03 | 0 |
| GO:CC | GO:0000800 | lateral element | "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh] | 4 | 1.020452e-02 | 0 |
| GO:CC | GO:0030870 | Mre11 complex | "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145] | 3 | 1.091051e-02 | 0 |
| GO:CC | GO:0001673 | male germ cell nucleus | "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu] | 6 | 1.399016e-02 | 0 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 172 | 1.731317e-02 | 0 |
| GO:CC | GO:0030893 | meiotic cohesin complex | "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522] | 3 | 1.893394e-02 | 0 |
| GO:CC | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex | "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV." [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889] | 3 | 1.893394e-02 | 0 |
| GO:CC | GO:0016591 | RNA polymerase II, holoenzyme | "A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters." [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii] | 7 | 2.649647e-02 | 0 |
| GO:CC | GO:0070461 | SAGA-type complex | "A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs)." [GOC:mah, PMID:10637607, PMID:17337012] | 5 | 2.916145e-02 | 0 |
| GO:CC | GO:0071144 | heteromeric SMAD protein complex | "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020] | 3 | 3.004142e-02 | 0 |
| GO:CC | GO:0005664 | nuclear origin of replication recognition complex | "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] | 3 | 3.004142e-02 | 0 |
| GO:CC | GO:0000808 | origin recognition complex | "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] | 3 | 3.004142e-02 | 0 |
| GO:CC | GO:0031965 | nuclear membrane | "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] | 13 | 3.111266e-02 | 0 |
| GO:CC | GO:0099086 | synaptonemal structure | "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh, GOC:vw] | 5 | 3.726516e-02 | 0 |
| GO:CC | GO:0000795 | synaptonemal complex | "A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element." [DOI:10.5772/29752, GOC:elh] | 5 | 3.726516e-02 | 0 |
| GO:CC | GO:0070603 | SWI/SNF superfamily-type complex | "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938] | 7 | 4.012766e-02 | 0 |
| GO:CC | GO:0070419 | nonhomologous end joining complex | "A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends." [GOC:mah, PMID:17072889, PMID:17938628] | 3 | 4.468619e-02 | 0 |
| GO:CC | GO:0071141 | SMAD protein complex | "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020] | 3 | 4.468619e-02 | 0 |
| GO:CC | GO:0005680 | anaphase-promoting complex | "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] | 4 | 4.665649e-02 | 0 |
| GO:CC | GO:1902562 | H4 histone acetyltransferase complex | "A protein complex which is capable of H4 histone acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:23775086] | 5 | 4.699588e-02 | 0 |
| GO:CC | GO:0097131 | cyclin D1-CDK6 complex | "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.995938e-02 | 0 |
| GO:CC | GO:0097128 | cyclin D1-CDK4 complex | "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.995938e-02 | 0 |
| GO:CC | GO:0097130 | cyclin D3-CDK4 complex | "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.995938e-02 | 0 |
| GO:CC | GO:0097121 | cyclin A1-CDK1 complex | "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.995938e-02 | 0 |
| GO:CC | GO:0097122 | cyclin A2-CDK1 complex | "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.995938e-02 | 0 |
| GO:CC | GO:0097133 | cyclin D3-CDK6 complex | "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.995938e-02 | 0 |
| GO:CC | GO:0097123 | cyclin A1-CDK2 complex | "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.995938e-02 | 0 |
| GO:CC | GO:0097135 | cyclin E2-CDK2 complex | "A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.995938e-02 | 0 |
| GO:CC | GO:0097125 | cyclin B1-CDK1 complex | "A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 4.995938e-02 | 0 |
| GO:CC | GO:0070557 | PCNA-p21 complex | "A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication." [GOC:mah, PMID:7911228, PMID:7915843] | 2 | 4.995938e-02 | 0 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 129 | 5.470270e-72 | 0 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 93 | 8.124342e-67 | 0 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 99 | 8.898058e-67 | 0 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 101 | 4.575237e-64 | 0 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 106 | 3.251453e-59 | 0 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 77 | 7.423404e-59 | 0 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 99 | 1.884044e-58 | 0 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 70 | 1.015766e-56 | 0 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 60 | 5.627008e-55 | 0 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 84 | 1.018409e-48 | 0 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 65 | 4.217546e-46 | 0 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 69 | 3.910555e-44 | 0 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 172 | 5.624514e-44 | 0 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 59 | 1.540803e-42 | 0 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 183 | 1.311888e-40 | 0 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 52 | 3.275411e-40 | 0 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 69 | 7.787707e-40 | 0 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 101 | 2.012407e-39 | 0 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 143 | 2.027177e-38 | 0 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 186 | 1.633763e-37 | 0 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 57 | 3.287642e-36 | 0 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 127 | 1.101861e-35 | 0 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 40 | 4.110944e-34 | 0 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 41 | 4.512322e-33 | 0 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 129 | 5.219231e-33 | 0 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 96 | 2.815288e-31 | 0 |
| GO:BP | GO:0006261 | DNA-templated DNA replication | "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] | 35 | 4.167303e-31 | 0 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 47 | 5.639835e-31 | 0 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 58 | 1.069381e-30 | 0 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 159 | 1.024841e-28 | 0 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 120 | 2.826315e-27 | 0 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 117 | 6.554920e-27 | 0 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 117 | 1.103018e-26 | 0 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 159 | 1.173409e-25 | 0 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 124 | 1.937951e-25 | 0 |
| GO:BP | GO:0006275 | regulation of DNA replication | "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] | 28 | 3.169354e-25 | 0 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 173 | 6.697741e-25 | 0 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 76 | 8.522927e-25 | 0 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 49 | 1.071127e-24 | 0 |
| GO:BP | GO:0044839 | cell cycle G2/M phase transition | "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle] | 30 | 1.674420e-24 | 0 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 118 | 2.121806e-24 | 0 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 79 | 4.153546e-24 | 0 |
| GO:BP | GO:0008283 | cell population proliferation | "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] | 86 | 4.159831e-24 | 0 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 79 | 4.489945e-24 | 0 |
| GO:BP | GO:0000086 | G2/M transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] | 28 | 2.645553e-23 | 0 |
| GO:BP | GO:0010948 | negative regulation of cell cycle process | "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 36 | 5.295842e-23 | 0 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 219 | 5.547703e-23 | 0 |
| GO:BP | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] | 23 | 1.261549e-22 | 0 |
| GO:BP | GO:1902749 | regulation of cell cycle G2/M phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 26 | 1.485878e-22 | 0 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 176 | 1.525022e-22 | 0 |
| GO:BP | GO:0010389 | regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565] | 25 | 1.640488e-22 | 0 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 79 | 6.909262e-22 | 0 |
| GO:BP | GO:1901988 | negative regulation of cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 33 | 8.396637e-22 | 0 |
| GO:BP | GO:0051338 | regulation of transferase activity | "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] | 43 | 1.791678e-21 | 0 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 96 | 1.803605e-21 | 0 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 143 | 3.250919e-21 | 0 |
| GO:BP | GO:0045787 | positive regulation of cell cycle | "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] | 37 | 4.163945e-21 | 0 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 93 | 5.621251e-21 | 0 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 141 | 5.967569e-21 | 0 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 70 | 7.007781e-21 | 0 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 218 | 2.165518e-20 | 0 |
| GO:BP | GO:0006270 | DNA replication initiation | "The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641] | 17 | 2.530323e-20 | 0 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 64 | 3.083342e-20 | 0 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] | 64 | 6.010297e-20 | 0 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 96 | 6.786237e-20 | 0 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 143 | 6.797348e-20 | 0 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 91 | 6.938127e-20 | 0 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 93 | 9.460255e-20 | 0 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 33 | 1.497567e-19 | 0 |
| GO:BP | GO:0006302 | double-strand break repair | "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] | 34 | 2.451770e-19 | 0 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] | 72 | 2.751009e-19 | 0 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 65 | 7.034495e-19 | 0 |
| GO:BP | GO:0006325 | chromatin organization | "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] | 52 | 7.532806e-19 | 0 |
| GO:BP | GO:0016310 | phosphorylation | "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] | 63 | 8.614948e-19 | 0 |
| GO:BP | GO:0000075 | cell cycle checkpoint signaling | "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] | 27 | 1.755430e-18 | 0 |
| GO:BP | GO:0045930 | negative regulation of mitotic cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 29 | 1.835273e-18 | 0 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 25 | 2.068934e-18 | 0 |
| GO:BP | GO:0051321 | meiotic cell cycle | "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] | 32 | 3.396320e-18 | 0 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 74 | 3.459648e-18 | 0 |
| GO:BP | GO:0050794 | regulation of cellular process | "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] | 211 | 3.743056e-18 | 0 |
| GO:BP | GO:0006310 | DNA recombination | "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] | 34 | 3.757874e-18 | 0 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 96 | 6.586732e-18 | 0 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 52 | 6.643577e-18 | 0 |
| GO:BP | GO:0006468 | protein phosphorylation | "The process of introducing a phosphate group on to a protein." [GOC:hb] | 59 | 1.680056e-17 | 0 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 25 | 2.016277e-17 | 0 |
| GO:BP | GO:0050789 | regulation of biological process | "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] | 213 | 4.023822e-17 | 0 |
| GO:BP | GO:0031399 | regulation of protein modification process | "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 54 | 4.867886e-17 | 0 |
| GO:BP | GO:0043549 | regulation of kinase activity | "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] | 36 | 4.877845e-17 | 0 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 138 | 5.203413e-17 | 0 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] | 59 | 5.241110e-17 | 0 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 135 | 6.011916e-17 | 0 |
| GO:BP | GO:1901991 | negative regulation of mitotic cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 25 | 6.709452e-17 | 0 |
| GO:BP | GO:0000725 | recombinational repair | "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] | 26 | 8.290687e-17 | 0 |
| GO:BP | GO:0006338 | chromatin remodeling | "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] | 45 | 8.672376e-17 | 0 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 100 | 8.681303e-17 | 0 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 158 | 9.411160e-17 | 0 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 25 | 1.194894e-16 | 0 |
| GO:BP | GO:0031570 | DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] | 22 | 1.237241e-16 | 0 |
| GO:BP | GO:1901992 | positive regulation of mitotic cell cycle phase transition | "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 20 | 1.294347e-16 | 0 |
| GO:BP | GO:0090068 | positive regulation of cell cycle process | "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 29 | 1.369527e-16 | 0 |
| GO:BP | GO:0045931 | positive regulation of mitotic cell cycle | "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 22 | 1.488509e-16 | 0 |
| GO:BP | GO:0033044 | regulation of chromosome organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] | 28 | 1.851926e-16 | 0 |
| GO:BP | GO:0000280 | nuclear division | "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] | 36 | 2.351189e-16 | 0 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 95 | 4.491128e-16 | 0 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 25 | 9.157524e-16 | 0 |
| GO:BP | GO:0007059 | chromosome segregation | "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] | 34 | 2.666985e-15 | 0 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 49 | 4.486218e-15 | 0 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] | 49 | 4.682387e-15 | 0 |
| GO:BP | GO:0048285 | organelle fission | "The creation of two or more organelles by division of one organelle." [GOC:jid] | 36 | 6.309989e-15 | 0 |
| GO:BP | GO:0022616 | DNA strand elongation | "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:isa_complete, GOC:mah] | 14 | 6.814429e-15 | 0 |
| GO:BP | GO:0065007 | biological regulation | "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 213 | 7.810983e-15 | 0 |
| GO:BP | GO:0000724 | double-strand break repair via homologous recombination | "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] | 24 | 8.672565e-15 | 0 |
| GO:BP | GO:1901989 | positive regulation of cell cycle phase transition | "Any process that activates or increases the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 20 | 9.393740e-15 | 0 |
| GO:BP | GO:0042325 | regulation of phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] | 45 | 1.622036e-14 | 0 |
| GO:BP | GO:0007093 | mitotic cell cycle checkpoint signaling | "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] | 21 | 2.098421e-14 | 0 |
| GO:BP | GO:0071900 | regulation of protein serine/threonine kinase activity | "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] | 26 | 2.595622e-14 | 0 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 224 | 4.768559e-14 | 0 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 59 | 7.041732e-14 | 0 |
| GO:BP | GO:0045859 | regulation of protein kinase activity | "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] | 31 | 2.424852e-13 | 0 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 59 | 2.756259e-13 | 0 |
| GO:BP | GO:0098813 | nuclear chromosome segregation | "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos] | 28 | 3.966988e-13 | 0 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 114 | 4.716307e-13 | 0 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 67 | 5.299727e-13 | 0 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 68 | 7.324206e-13 | 0 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 68 | 8.108414e-13 | 0 |
| GO:BP | GO:0048144 | fibroblast proliferation | "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] | 18 | 1.392723e-12 | 0 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] | 41 | 1.574371e-12 | 0 |
| GO:BP | GO:0033260 | nuclear DNA replication | "The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] | 13 | 1.661595e-12 | 0 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] | 39 | 1.779190e-12 | 0 |
| GO:BP | GO:0009314 | response to radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] | 31 | 2.483819e-12 | 0 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 21 | 2.849550e-12 | 0 |
| GO:BP | GO:0000077 | DNA damage checkpoint signaling | "A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah] | 18 | 3.174085e-12 | 0 |
| GO:BP | GO:0009411 | response to UV | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] | 20 | 4.655145e-12 | 0 |
| GO:BP | GO:0006282 | regulation of DNA repair | "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] | 23 | 6.217960e-12 | 0 |
| GO:BP | GO:0044786 | cell cycle DNA replication | "The DNA-dependent DNA replication that takes place as part of the cell cycle." [GOC:mtg_cell_cycle] | 13 | 6.601930e-12 | 0 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 167 | 1.372055e-11 | 0 |
| GO:BP | GO:0044774 | mitotic DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle] | 15 | 1.559831e-11 | 0 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 79 | 2.337399e-11 | 0 |
| GO:BP | GO:0042770 | signal transduction in response to DNA damage | "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators] | 20 | 3.986855e-11 | 0 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 79 | 8.904145e-11 | 0 |
| GO:BP | GO:0140014 | mitotic nuclear division | "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684] | 24 | 9.298229e-11 | 0 |
| GO:BP | GO:0061982 | meiosis I cell cycle process | "A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs." [PMID:29385397] | 18 | 1.456971e-10 | 0 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 71 | 2.642596e-10 | 0 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 71 | 2.810418e-10 | 0 |
| GO:BP | GO:0048511 | rhythmic process | "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] | 24 | 5.193643e-10 | 0 |
| GO:BP | GO:1903046 | meiotic cell cycle process | "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 21 | 5.757711e-10 | 0 |
| GO:BP | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb] | 10 | 9.477127e-10 | 0 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 135 | 1.038683e-09 | 0 |
| GO:BP | GO:0009628 | response to abiotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] | 45 | 1.870157e-09 | 0 |
| GO:BP | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 13 | 2.718011e-09 | 0 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 32 | 2.885602e-09 | 0 |
| GO:BP | GO:1902751 | positive regulation of cell cycle G2/M phase transition | "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 10 | 3.104749e-09 | 0 |
| GO:BP | GO:0044773 | mitotic DNA damage checkpoint signaling | "A signal transduction process involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] | 13 | 3.303120e-09 | 0 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] | 40 | 3.404513e-09 | 0 |
| GO:BP | GO:0019953 | sexual reproduction | "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] | 44 | 3.868125e-09 | 0 |
| GO:BP | GO:0030174 | regulation of DNA-templated DNA replication initiation | "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah] | 8 | 3.982858e-09 | 0 |
| GO:BP | GO:0006271 | DNA strand elongation involved in DNA replication | "The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication." [GOC:mah, ISBN:071673706X, ISBN:0815316194] | 8 | 3.982858e-09 | 0 |
| GO:BP | GO:1902750 | negative regulation of cell cycle G2/M phase transition | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 13 | 4.001334e-09 | 0 |
| GO:BP | GO:0045740 | positive regulation of DNA replication | "Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators] | 11 | 4.079012e-09 | 0 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] | 40 | 5.778041e-09 | 0 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 44 | 8.325270e-09 | 0 |
| GO:BP | GO:0080135 | regulation of cellular response to stress | "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 29 | 8.879627e-09 | 0 |
| GO:BP | GO:0000819 | sister chromatid segregation | "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] | 20 | 1.201357e-08 | 0 |
| GO:BP | GO:0022414 | reproductive process | "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] | 53 | 1.253289e-08 | 0 |
| GO:BP | GO:0009416 | response to light stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] | 23 | 1.312909e-08 | 0 |
| GO:BP | GO:0010212 | response to ionizing radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] | 16 | 2.295517e-08 | 0 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 135 | 3.241176e-08 | 0 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 86 | 3.408769e-08 | 0 |
| GO:BP | GO:0000727 | double-strand break repair via break-induced replication | "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855] | 7 | 4.348333e-08 | 0 |
| GO:BP | GO:0044093 | positive regulation of molecular function | "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 37 | 4.411390e-08 | 0 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 14 | 5.016315e-08 | 0 |
| GO:BP | GO:0090329 | regulation of DNA-templated DNA replication | "Any process that modulates the rate, frequency, or extent of DNA-templated DNA replication, the process in which new strands of DNA are synthesized." [GOC:dph, GOC:tb] | 10 | 5.404556e-08 | 0 |
| GO:BP | GO:0010165 | response to X-ray | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] | 9 | 6.211305e-08 | 0 |
| GO:BP | GO:0140013 | meiotic nuclear division | "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324] | 18 | 7.063598e-08 | 0 |
| GO:BP | GO:0044818 | mitotic G2/M transition checkpoint | "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] | 11 | 7.487556e-08 | 0 |
| GO:BP | GO:0048145 | regulation of fibroblast proliferation | "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] | 13 | 9.274642e-08 | 0 |
| GO:BP | GO:0051983 | regulation of chromosome segregation | "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] | 15 | 1.002081e-07 | 0 |
| GO:BP | GO:0071478 | cellular response to radiation | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:mah] | 17 | 1.191596e-07 | 0 |
| GO:BP | GO:0051347 | positive regulation of transferase activity | "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] | 21 | 1.200955e-07 | 0 |
| GO:BP | GO:0045005 | DNA-templated DNA replication maintenance of fidelity | "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw] | 11 | 1.679853e-07 | 0 |
| GO:BP | GO:0045739 | positive regulation of DNA repair | "Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators] | 15 | 1.713584e-07 | 0 |
| GO:BP | GO:0051053 | negative regulation of DNA metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 15 | 2.110357e-07 | 0 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 164 | 2.483613e-07 | 0 |
| GO:BP | GO:0000070 | mitotic sister chromatid segregation | "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] | 17 | 3.012221e-07 | 0 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 39 | 3.023774e-07 | 0 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 21 | 3.187134e-07 | 0 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 21 | 4.524667e-07 | 0 |
| GO:BP | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis] | 12 | 5.168791e-07 | 0 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 35 | 5.360820e-07 | 0 |
| GO:BP | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] | 13 | 6.734062e-07 | 0 |
| GO:BP | GO:0031297 | replication fork processing | "The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542] | 10 | 7.268172e-07 | 0 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 126 | 7.543074e-07 | 0 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 27 | 7.837208e-07 | 0 |
| GO:BP | GO:0051402 | neuron apoptotic process | "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis] | 20 | 8.253734e-07 | 0 |
| GO:BP | GO:0110025 | DNA strand resection involved in replication fork processing | "The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing." [GOC:mah, PMID:28475874] | 6 | 1.008161e-06 | 0 |
| GO:BP | GO:1902969 | mitotic DNA replication | "Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] | 7 | 1.015089e-06 | 0 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] | 27 | 1.078270e-06 | 0 |
| GO:BP | GO:0009790 | embryo development | "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] | 40 | 1.094645e-06 | 0 |
| GO:BP | GO:0007127 | meiosis I | "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324] | 14 | 1.247477e-06 | 0 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 35 | 1.352244e-06 | 0 |
| GO:BP | GO:0043523 | regulation of neuron apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] | 18 | 1.369113e-06 | 0 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 13 | 1.522937e-06 | 0 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 72 | 1.686088e-06 | 0 |
| GO:BP | GO:0001701 | in utero embryonic development | "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] | 23 | 1.746541e-06 | 0 |
| GO:BP | GO:0070482 | response to oxygen levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] | 21 | 1.890664e-06 | 0 |
| GO:BP | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 10 | 1.923034e-06 | 0 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 15 | 2.194397e-06 | 0 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 63 | 2.286363e-06 | 0 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 123 | 2.423126e-06 | 0 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 127 | 2.771821e-06 | 0 |
| GO:BP | GO:0051984 | positive regulation of chromosome segregation | "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] | 8 | 3.107161e-06 | 0 |
| GO:BP | GO:2000779 | regulation of double-strand break repair | "Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF] | 14 | 3.262301e-06 | 0 |
| GO:BP | GO:1902807 | negative regulation of cell cycle G1/S phase transition | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 10 | 4.624154e-06 | 0 |
| GO:BP | GO:0090398 | cellular senescence | "A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest." [GOC:BHF, PMID:28682291] | 12 | 5.271272e-06 | 0 |
| GO:BP | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] | 9 | 5.734146e-06 | 0 |
| GO:BP | GO:0045595 | regulation of cell differentiation | "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] | 47 | 6.555443e-06 | 0 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 20 | 7.044928e-06 | 0 |
| GO:BP | GO:0006289 | nucleotide-excision repair | "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] | 11 | 7.545840e-06 | 0 |
| GO:BP | GO:0104004 | cellular response to environmental stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus." [GOC:dos] | 20 | 8.625168e-06 | 0 |
| GO:BP | GO:0071214 | cellular response to abiotic stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah] | 20 | 8.625168e-06 | 0 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 114 | 8.676483e-06 | 0 |
| GO:BP | GO:0043065 | positive regulation of apoptotic process | "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 25 | 8.738862e-06 | 0 |
| GO:BP | GO:0006352 | DNA-templated transcription initiation | "The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161] | 16 | 8.783775e-06 | 0 |
| GO:BP | GO:0008315 | G2/MI transition of meiotic cell cycle | "The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I." [PMID:15084480] | 5 | 8.864347e-06 | 0 |
| GO:BP | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators, GOC:pr] | 8 | 9.252444e-06 | 0 |
| GO:BP | GO:0040007 | growth | "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] | 34 | 9.836382e-06 | 0 |
| GO:BP | GO:0009719 | response to endogenous stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] | 45 | 1.006629e-05 | 0 |
| GO:BP | GO:0033045 | regulation of sister chromatid segregation | "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] | 12 | 1.029548e-05 | 0 |
| GO:BP | GO:0080134 | regulation of response to stress | "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] | 43 | 1.109466e-05 | 0 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 96 | 1.305560e-05 | 0 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 154 | 1.413648e-05 | 0 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 36 | 1.421100e-05 | 0 |
| GO:BP | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity | "Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] | 8 | 1.510873e-05 | 0 |
| GO:BP | GO:0006301 | postreplication repair | "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh] | 8 | 1.510873e-05 | 0 |
| GO:BP | GO:0010332 | response to gamma radiation | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators] | 9 | 1.800066e-05 | 0 |
| GO:BP | GO:0050793 | regulation of developmental process | "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] | 61 | 2.271393e-05 | 0 |
| GO:BP | GO:0044771 | meiotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase." [GOC:mtg_cell_cycle] | 6 | 2.286189e-05 | 0 |
| GO:BP | GO:0018205 | peptidyl-lysine modification | "The modification of peptidyl-lysine." [GOC:go_curators] | 13 | 2.399424e-05 | 0 |
| GO:BP | GO:0071479 | cellular response to ionizing radiation | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah] | 10 | 2.453346e-05 | 0 |
| GO:BP | GO:0048146 | positive regulation of fibroblast proliferation | "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] | 9 | 2.548858e-05 | 0 |
| GO:BP | GO:2000781 | positive regulation of double-strand break repair | "Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF] | 11 | 2.568129e-05 | 0 |
| GO:BP | GO:0045926 | negative regulation of growth | "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] | 16 | 2.841982e-05 | 0 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] | 39 | 2.969330e-05 | 0 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] | 28 | 3.055002e-05 | 0 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 32 | 3.299168e-05 | 0 |
| GO:BP | GO:0000018 | regulation of DNA recombination | "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732] | 13 | 3.373818e-05 | 0 |
| GO:BP | GO:0045165 | cell fate commitment | "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185] | 18 | 3.465083e-05 | 0 |
| GO:BP | GO:0051169 | nuclear transport | "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] | 19 | 3.824603e-05 | 0 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] | 19 | 3.824603e-05 | 0 |
| GO:BP | GO:0040029 | epigenetic regulation of gene expression | "A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474] | 18 | 3.842495e-05 | 0 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 140 | 4.009743e-05 | 0 |
| GO:BP | GO:0051094 | positive regulation of developmental process | "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 41 | 4.094134e-05 | 0 |
| GO:BP | GO:0001666 | response to hypoxia | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] | 18 | 4.479905e-05 | 0 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 23 | 4.736603e-05 | 0 |
| GO:BP | GO:0072359 | circulatory system development | "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] | 37 | 5.197415e-05 | 0 |
| GO:BP | GO:0009888 | tissue development | "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] | 53 | 5.386956e-05 | 0 |
| GO:BP | GO:0048513 | animal organ development | "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] | 70 | 5.475247e-05 | 0 |
| GO:BP | GO:0030154 | cell differentiation | "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] | 90 | 5.719667e-05 | 0 |
| GO:BP | GO:0048869 | cellular developmental process | "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] | 90 | 5.783478e-05 | 0 |
| GO:BP | GO:0043009 | chordate embryonic development | "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] | 27 | 6.297799e-05 | 0 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] | 42 | 6.307503e-05 | 0 |
| GO:BP | GO:0034502 | protein localization to chromosome | "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah] | 12 | 6.631831e-05 | 0 |
| GO:BP | GO:0048469 | cell maturation | "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state." [GOC:go_curators] | 15 | 6.824915e-05 | 0 |
| GO:BP | GO:0021700 | developmental maturation | "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] | 19 | 8.818746e-05 | 0 |
| GO:BP | GO:0036293 | response to decreased oxygen levels | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] | 18 | 8.949040e-05 | 0 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 21 | 9.439330e-05 | 0 |
| GO:BP | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 8 | 9.817062e-05 | 0 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] | 55 | 1.030859e-04 | 0 |
| GO:BP | GO:0051093 | negative regulation of developmental process | "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] | 32 | 1.077727e-04 | 0 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 141 | 1.220766e-04 | 0 |
| GO:BP | GO:0060429 | epithelium development | "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] | 38 | 1.262154e-04 | 0 |
| GO:BP | GO:0033674 | positive regulation of kinase activity | "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] | 16 | 1.287973e-04 | 0 |
| GO:BP | GO:0030855 | epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] | 28 | 1.485193e-04 | 0 |
| GO:BP | GO:0030218 | erythrocyte differentiation | "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah] | 12 | 1.556368e-04 | 0 |
| GO:BP | GO:0042221 | response to chemical | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] | 81 | 1.666507e-04 | 0 |
| GO:BP | GO:0110030 | regulation of G2/MI transition of meiotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw] | 4 | 1.829274e-04 | 0 |
| GO:BP | GO:0006606 | protein import into nucleus | "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] | 13 | 1.835858e-04 | 0 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 19 | 1.849740e-04 | 0 |
| GO:BP | GO:0071824 | protein-DNA complex organization | "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." [GOC:mah] | 16 | 1.974427e-04 | 0 |
| GO:BP | GO:0051445 | regulation of meiotic cell cycle | "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 9 | 2.044931e-04 | 0 |
| GO:BP | GO:0034644 | cellular response to UV | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah] | 10 | 2.172243e-04 | 0 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 31 | 2.318551e-04 | 0 |
| GO:BP | GO:0018394 | peptidyl-lysine acetylation | "The acetylation of peptidyl-lysine." [GOC:mah] | 6 | 2.335186e-04 | 0 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] | 26 | 2.344990e-04 | 0 |
| GO:BP | GO:0048732 | gland development | "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] | 21 | 2.357396e-04 | 0 |
| GO:BP | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah] | 12 | 2.508134e-04 | 0 |
| GO:BP | GO:0051170 | import into nucleus | "The directed movement of substances into the nucleus." [GOC:ai] | 13 | 2.599889e-04 | 0 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 19 | 2.919695e-04 | 0 |
| GO:BP | GO:1903844 | regulation of cellular response to transforming growth factor beta stimulus | "Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] | 12 | 3.155952e-04 | 0 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] | 25 | 3.367736e-04 | 0 |
| GO:BP | GO:0030097 | hemopoiesis | "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] | 32 | 3.636606e-04 | 0 |
| GO:BP | GO:0043687 | post-translational protein modification | "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] | 33 | 3.645469e-04 | 0 |
| GO:BP | GO:0034101 | erythrocyte homeostasis | "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] | 12 | 3.666930e-04 | 0 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | "The alteration of an amino acid residue in a peptide." [GOC:mah] | 26 | 3.706486e-04 | 0 |
| GO:BP | GO:0007179 | transforming growth factor beta receptor signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] | 14 | 3.864762e-04 | 0 |
| GO:BP | GO:0065004 | protein-DNA complex assembly | "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] | 15 | 3.904493e-04 | 0 |
| GO:BP | GO:0071695 | anatomical structure maturation | "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah] | 16 | 4.218071e-04 | 0 |
| GO:BP | GO:0048583 | regulation of response to stimulus | "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 81 | 4.230551e-04 | 0 |
| GO:BP | GO:0007623 | circadian rhythm | "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] | 14 | 4.346100e-04 | 0 |
| GO:BP | GO:0007095 | mitotic G2 DNA damage checkpoint signaling | "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494] | 7 | 4.390758e-04 | 0 |
| GO:BP | GO:2001251 | negative regulation of chromosome organization | "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol] | 10 | 4.441810e-04 | 0 |
| GO:BP | GO:0040008 | regulation of growth | "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] | 24 | 4.812286e-04 | 0 |
| GO:BP | GO:0007507 | heart development | "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] | 24 | 4.958813e-04 | 0 |
| GO:BP | GO:0051098 | regulation of binding | "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] | 14 | 5.169718e-04 | 0 |
| GO:BP | GO:0060284 | regulation of cell development | "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] | 29 | 5.920173e-04 | 0 |
| GO:BP | GO:0050000 | chromosome localization | "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai] | 11 | 6.072422e-04 | 0 |
| GO:BP | GO:1905818 | regulation of chromosome separation | "Any process that modulates the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393] | 9 | 6.102345e-04 | 0 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 36 | 6.116859e-04 | 0 |
| GO:BP | GO:0050673 | epithelial cell proliferation | "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] | 20 | 6.511572e-04 | 0 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] | 65 | 6.636999e-04 | 0 |
| GO:BP | GO:0007062 | sister chromatid cohesion | "The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other." [GOC:jh, GOC:mah, ISBN:0815316194] | 8 | 6.658290e-04 | 0 |
| GO:BP | GO:0045911 | positive regulation of DNA recombination | "Any process that activates or increases the frequency, rate or extent of DNA recombination." [GOC:go_curators] | 9 | 6.827735e-04 | 0 |
| GO:BP | GO:0006287 | base-excision repair, gap-filling | "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131] | 5 | 7.895468e-04 | 0 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 165 | 8.438807e-04 | 0 |
| GO:BP | GO:0048872 | homeostasis of number of cells | "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete] | 17 | 9.637691e-04 | 0 |
| GO:BP | GO:1902808 | positive regulation of cell cycle G1/S phase transition | "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 8 | 1.139176e-03 | 0 |
| GO:BP | GO:0044027 | negative regulation of gene expression via chromosomal CpG island methylation | "An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide associated with the transcription start site of genes." [PMID:11898023, Wikipedia:Cpg_island] | 5 | 1.172889e-03 | 0 |
| GO:BP | GO:0010720 | positive regulation of cell development | "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] | 20 | 1.179804e-03 | 0 |
| GO:BP | GO:0016233 | telomere capping | "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055] | 6 | 1.200176e-03 | 0 |
| GO:BP | GO:1905168 | positive regulation of double-strand break repair via homologous recombination | "Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299] | 7 | 1.293592e-03 | 0 |
| GO:BP | GO:0051304 | chromosome separation | "The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II)." [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243] | 9 | 1.295861e-03 | 0 |
| GO:BP | GO:0051225 | spindle assembly | "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] | 11 | 1.311672e-03 | 0 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] | 15 | 1.514218e-03 | 0 |
| GO:BP | GO:0000731 | DNA synthesis involved in DNA repair | "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855] | 7 | 1.522898e-03 | 0 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] | 54 | 1.820239e-03 | 0 |
| GO:BP | GO:0006367 | transcription initiation at RNA polymerase II promoter | "A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH] | 12 | 1.873071e-03 | 0 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 33 | 1.882842e-03 | 0 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 22 | 1.883456e-03 | 0 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 22 | 1.883456e-03 | 0 |
| GO:BP | GO:0006284 | base-excision repair | "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] | 7 | 2.084681e-03 | 0 |
| GO:BP | GO:0030308 | negative regulation of cell growth | "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] | 12 | 2.252374e-03 | 0 |
| GO:BP | GO:0007000 | nucleolus organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] | 5 | 2.370450e-03 | 0 |
| GO:BP | GO:0007165 | signal transduction | "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] | 106 | 2.652911e-03 | 0 |
| GO:BP | GO:1900180 | regulation of protein localization to nucleus | "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 11 | 2.656690e-03 | 0 |
| GO:BP | GO:0001934 | positive regulation of protein phosphorylation | "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] | 20 | 2.685030e-03 | 0 |
| GO:BP | GO:0051303 | establishment of chromosome localization | "The directed movement of a chromosome to a specific location." [GOC:ai] | 10 | 2.770102e-03 | 0 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb] | 16 | 2.870984e-03 | 0 |
| GO:BP | GO:0071163 | DNA replication preinitiation complex assembly | "The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins as part of initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity." [GOC:mah, PMID:28209641] | 3 | 3.155997e-03 | 0 |
| GO:BP | GO:0110032 | positive regulation of G2/MI transition of meiotic cell cycle | "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw, PMID:25492408] | 3 | 3.155997e-03 | 0 |
| GO:BP | GO:0051783 | regulation of nuclear division | "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] | 11 | 3.246695e-03 | 0 |
| GO:BP | GO:0006303 | double-strand break repair via nonhomologous end joining | "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021] | 8 | 3.331881e-03 | 0 |
| GO:BP | GO:0048731 | system development | "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] | 79 | 3.350676e-03 | 0 |
| GO:BP | GO:0002262 | myeloid cell homeostasis | "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] | 12 | 3.413338e-03 | 0 |
| GO:BP | GO:0007178 | cell surface receptor protein serine/threonine kinase signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] | 17 | 3.416268e-03 | 0 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] | 17 | 3.416268e-03 | 0 |
| GO:BP | GO:0007088 | regulation of mitotic nuclear division | "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] | 10 | 3.486616e-03 | 0 |
| GO:BP | GO:1905820 | positive regulation of chromosome separation | "Any process that activates or increases the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393] | 6 | 3.496393e-03 | 0 |
| GO:BP | GO:0071482 | cellular response to light stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah] | 10 | 3.758882e-03 | 0 |
| GO:BP | GO:0045132 | meiotic chromosome segregation | "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah] | 9 | 4.034599e-03 | 0 |
| GO:BP | GO:0023052 | signaling | "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] | 112 | 4.139579e-03 | 0 |
| GO:BP | GO:0031023 | microtubule organizing center organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] | 11 | 4.210780e-03 | 0 |
| GO:BP | GO:0043247 | telomere maintenance in response to DNA damage | "Any process that occur in response to the presence of critically short or damaged telomeres." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:15279784] | 6 | 4.231214e-03 | 0 |
| GO:BP | GO:1904030 | negative regulation of cyclin-dependent protein kinase activity | "Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] | 5 | 4.368864e-03 | 0 |
| GO:BP | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | "The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783] | 9 | 4.401801e-03 | 0 |
| GO:BP | GO:0000183 | rDNA heterochromatin formation | "The formation of heterochromatin at ribosomal DNA, characterized by the modified histone H3K9me3." [PMID:10219245] | 4 | 4.440391e-03 | 0 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 42 | 4.936161e-03 | 0 |
| GO:BP | GO:0007154 | cell communication | "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] | 112 | 5.063623e-03 | 0 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] | 20 | 5.445263e-03 | 0 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 8 | 5.658897e-03 | 0 |
| GO:BP | GO:0044784 | metaphase/anaphase transition of cell cycle | "The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle." [GOC:mtg_cell_cycle] | 9 | 5.681235e-03 | 0 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575] | 14 | 6.104926e-03 | 0 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 8 | 6.260593e-03 | 0 |
| GO:BP | GO:0008608 | attachment of spindle microtubules to kinetochore | "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137] | 7 | 6.363792e-03 | 0 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 24 | 6.620103e-03 | 0 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] | 27 | 6.856577e-03 | 0 |
| GO:BP | GO:0061614 | miRNA transcription | "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799] | 8 | 6.915707e-03 | 0 |
| GO:BP | GO:0060218 | hematopoietic stem cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083] | 6 | 7.223135e-03 | 0 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | "The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:22651914, PMID:28096268] | 16 | 7.293385e-03 | 0 |
| GO:BP | GO:1990700 | nucleolar chromatin organization | "Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin." [PMID:18362178] | 4 | 7.331773e-03 | 0 |
| GO:BP | GO:0051310 | metaphase chromosome alignment | "A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [GOC:vw] | 9 | 7.875611e-03 | 0 |
| GO:BP | GO:0006473 | protein acetylation | "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] | 7 | 8.167476e-03 | 0 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:mah] | 14 | 8.284198e-03 | 0 |
| GO:BP | GO:0071453 | cellular response to oxygen levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah] | 11 | 8.767719e-03 | 0 |
| GO:BP | GO:0007052 | mitotic spindle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah] | 10 | 8.785844e-03 | 0 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] | 7 | 9.217707e-03 | 0 |
| GO:BP | GO:0033047 | regulation of mitotic sister chromatid segregation | "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] | 7 | 9.217707e-03 | 0 |
| GO:BP | GO:0070199 | establishment of protein localization to chromosome | "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] | 5 | 9.610870e-03 | 0 |
| GO:BP | GO:0045814 | negative regulation of gene expression, epigenetic | "An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696] | 12 | 9.619407e-03 | 0 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 16 | 9.767336e-03 | 0 |
| GO:BP | GO:0070647 | protein modification by small protein conjugation or removal | "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] | 29 | 9.809774e-03 | 0 |
| GO:BP | GO:0071902 | positive regulation of protein serine/threonine kinase activity | "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] | 10 | 1.003249e-02 | 0 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 30 | 1.007260e-02 | 0 |
| GO:BP | GO:0060395 | SMAD protein signal transduction | "An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes." [GOC:BHF] | 8 | 1.014949e-02 | 0 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] | 23 | 1.047949e-02 | 0 |
| GO:BP | GO:0031099 | regeneration | "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass)." [GOC:mah, GOC:pr] | 12 | 1.065219e-02 | 0 |
| GO:BP | GO:1902850 | microtubule cytoskeleton organization involved in mitosis | "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626] | 11 | 1.103765e-02 | 0 |
| GO:BP | GO:0002520 | immune system development | "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] | 12 | 1.120421e-02 | 0 |
| GO:BP | GO:0045860 | positive regulation of protein kinase activity | "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] | 13 | 1.136248e-02 | 0 |
| GO:BP | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore | "Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] | 4 | 1.141417e-02 | 0 |
| GO:BP | GO:0071481 | cellular response to X-ray | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah] | 4 | 1.141417e-02 | 0 |
| GO:BP | GO:0030099 | myeloid cell differentiation | "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149] | 18 | 1.189826e-02 | 0 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 60 | 1.209813e-02 | 0 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906] | 20 | 1.215610e-02 | 0 |
| GO:BP | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore | "Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] | 5 | 1.216226e-02 | 0 |
| GO:BP | GO:0090042 | tubulin deacetylation | "The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:BHF, GOC:dph, GOC:tb] | 5 | 1.216226e-02 | 0 |
| GO:BP | GO:0010569 | regulation of double-strand break repair via homologous recombination | "Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb] | 8 | 1.219571e-02 | 0 |
| GO:BP | GO:0018076 | N-terminal peptidyl-lysine acetylation | "The acetylation of the N-terminal lysine of proteins." [GOC:ai] | 3 | 1.251320e-02 | 0 |
| GO:BP | GO:1901995 | positive regulation of meiotic cell cycle phase transition | "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 3 | 1.251320e-02 | 0 |
| GO:BP | GO:0031860 | telomeric 3' overhang formation | "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans." [PMID:16096639] | 3 | 1.251320e-02 | 0 |
| GO:BP | GO:0007098 | centrosome cycle | "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] | 10 | 1.299196e-02 | 0 |
| GO:BP | GO:0007051 | spindle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah] | 12 | 1.301403e-02 | 0 |
| GO:BP | GO:0033002 | muscle cell proliferation | "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah] | 12 | 1.435872e-02 | 0 |
| GO:BP | GO:0045732 | positive regulation of protein catabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] | 12 | 1.507566e-02 | 0 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] | 22 | 1.539591e-02 | 0 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 62 | 1.567540e-02 | 0 |
| GO:BP | GO:0048659 | smooth muscle cell proliferation | "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698] | 10 | 1.568112e-02 | 0 |
| GO:BP | GO:0042752 | regulation of circadian rhythm | "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] | 9 | 1.676871e-02 | 0 |
| GO:BP | GO:1901993 | regulation of meiotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 1.696202e-02 | 0 |
| GO:BP | GO:0002065 | columnar/cuboidal epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] | 9 | 1.800691e-02 | 0 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] | 42 | 1.816470e-02 | 0 |
| GO:BP | GO:0006476 | protein deacetylation | "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] | 6 | 1.833124e-02 | 0 |
| GO:BP | GO:0006312 | mitotic recombination | "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles." [GOC:elh] | 5 | 1.883552e-02 | 0 |
| GO:BP | GO:0031145 | anaphase-promoting complex-dependent catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442] | 5 | 1.883552e-02 | 0 |
| GO:BP | GO:0006997 | nucleus organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] | 10 | 2.000590e-02 | 0 |
| GO:BP | GO:0044092 | negative regulation of molecular function | "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] | 20 | 2.028502e-02 | 0 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 32 | 2.130936e-02 | 0 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 8 | 2.232094e-02 | 0 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] | 7 | 2.239628e-02 | 0 |
| GO:BP | GO:0043525 | positive regulation of neuron apoptotic process | "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] | 7 | 2.239628e-02 | 0 |
| GO:BP | GO:0030225 | macrophage differentiation | "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149] | 7 | 2.239628e-02 | 0 |
| GO:BP | GO:0070198 | protein localization to chromosome, telomeric region | "Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome." [GOC:BHF, GOC:mah] | 5 | 2.309569e-02 | 0 |
| GO:BP | GO:0008156 | negative regulation of DNA replication | "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators] | 5 | 2.309569e-02 | 0 |
| GO:BP | GO:0019985 | translesion synthesis | "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901] | 5 | 2.309569e-02 | 0 |
| GO:BP | GO:0002376 | immune system process | "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] | 59 | 2.356353e-02 | 0 |
| GO:BP | GO:0031571 | mitotic G1 DNA damage checkpoint signaling | "A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle] | 4 | 2.427290e-02 | 0 |
| GO:BP | GO:0070192 | chromosome organization involved in meiotic cell cycle | "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah] | 7 | 2.480295e-02 | 0 |
| GO:BP | GO:0031507 | heterochromatin formation | "An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation." [PMID:25192661, PMID:33827924] | 10 | 2.532308e-02 | 0 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 8 | 2.626376e-02 | 0 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] | 40 | 2.735743e-02 | 0 |
| GO:BP | GO:0001756 | somitogenesis | "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] | 7 | 2.741973e-02 | 0 |
| GO:BP | GO:0048589 | developmental growth | "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] | 22 | 2.796295e-02 | 0 |
| GO:BP | GO:0030071 | regulation of mitotic metaphase/anaphase transition | "Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mah] | 8 | 2.844513e-02 | 0 |
| GO:BP | GO:0035825 | homologous recombination | "A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules." [GOC:mah, PMID:11139492, PMID:17304215] | 7 | 3.026070e-02 | 0 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 12 | 3.028673e-02 | 0 |
| GO:BP | GO:0043550 | regulation of lipid kinase activity | "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf] | 3 | 3.100861e-02 | 0 |
| GO:BP | GO:1902975 | mitotic DNA replication initiation | "Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] | 3 | 3.100861e-02 | 0 |
| GO:BP | GO:1902315 | nuclear cell cycle DNA replication initiation | "Any DNA replication initiation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 3.100861e-02 | 0 |
| GO:BP | GO:1902292 | cell cycle DNA replication initiation | "Any DNA replication initiation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 3.100861e-02 | 0 |
| GO:BP | GO:0070345 | negative regulation of fat cell proliferation | "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] | 3 | 3.100861e-02 | 0 |
| GO:BP | GO:0045936 | negative regulation of phosphate metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] | 14 | 3.314805e-02 | 0 |
| GO:BP | GO:0010563 | negative regulation of phosphorus metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] | 14 | 3.314805e-02 | 0 |
| GO:BP | GO:0070848 | response to growth factor | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah] | 23 | 3.323842e-02 | 0 |
| GO:BP | GO:0016925 | protein sumoylation | "The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250] | 7 | 3.334064e-02 | 0 |
| GO:BP | GO:2000105 | positive regulation of DNA-templated DNA replication | "Any process that activates or increases the frequency, rate or extent of DNA-templated DNA replication." [GOC:mah] | 4 | 3.366625e-02 | 0 |
| GO:BP | GO:0044819 | mitotic G1/S transition checkpoint signaling | "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] | 4 | 3.366625e-02 | 0 |
| GO:BP | GO:0140718 | facultative heterochromatin formation | "The compaction of chromatin into a conformation that is refractory to transcription but that can be converted to euchromatin and allow transcription in specific contexts. These can be temporal (e.g., developmental states or specific cell-cycle stages), spatial (e.g., nuclear localization changes from the center to the periphery or vice versa due to exogenous factors/signals), or parental/heritable (e.g., monoallelic gene expression). In metazoa, this involves the methylation of histone H3K27." [PMID:17936700] | 4 | 3.366625e-02 | 0 |
| GO:BP | GO:0051177 | meiotic sister chromatid cohesion | "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai] | 4 | 3.366625e-02 | 0 |
| GO:BP | GO:0090235 | regulation of metaphase plate congression | "Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] | 4 | 3.366625e-02 | 0 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 34 | 3.438521e-02 | 0 |
| GO:BP | GO:1902099 | regulation of metaphase/anaphase transition of cell cycle | "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] | 8 | 3.592478e-02 | 0 |
| GO:BP | GO:0035295 | tube development | "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] | 30 | 3.638296e-02 | 0 |
| GO:BP | GO:0032922 | circadian regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah] | 7 | 3.667494e-02 | 0 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] | 22 | 3.850460e-02 | 0 |
| GO:BP | GO:0006360 | transcription by RNA polymerase I | "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] | 7 | 4.027973e-02 | 0 |
| GO:BP | GO:1901976 | regulation of cell cycle checkpoint | "Any process that modulates the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116] | 6 | 4.041161e-02 | 0 |
| GO:BP | GO:0098534 | centriole assembly | "A cellular process that results in the assembly of one or more centrioles." [GOC:dos, PMID:24075808] | 6 | 4.041161e-02 | 0 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 67 | 4.293062e-02 | 0 |
| GO:BP | GO:0034097 | response to cytokine | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] | 27 | 4.485450e-02 | 0 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 67 | 4.626792e-02 | 0 |
| GO:BP | GO:0002521 | leukocyte differentiation | "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] | 21 | 4.734997e-02 | 0 |
| GO:BP | GO:0006979 | response to oxidative stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] | 16 | 4.761074e-02 | 0 |
| GO:BP | GO:0007417 | central nervous system development | "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] | 29 | 4.784851e-02 | 0 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 7 | 4.836863e-02 | 0 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP179 | Cell cycle | Cell cycle | 59 | 1.447562e-64 | 0 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 40 | 1.415910e-40 | 0 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 34 | 2.121459e-37 | 0 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 29 | 6.660427e-27 | 0 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 28 | 3.128587e-26 | 0 |
| WP | WP:WP466 | DNA replication | DNA replication | 20 | 4.675450e-20 | 0 |
| WP | WP:WP4016 | DNA IR damage and cellular response via ATR | DNA IR damage and cellular response via ATR | 25 | 8.957429e-20 | 0 |
| WP | WP:WP1971 | Integrated cancer pathway | Integrated cancer pathway | 19 | 5.785647e-18 | 0 |
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 25 | 2.664247e-15 | 0 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 24 | 9.491982e-15 | 0 |
| WP | WP:WP3959 | DNA IR double strand breaks and cellular response via ATM | DNA IR double strand breaks and cellular response via ATM | 18 | 2.216424e-14 | 0 |
| WP | WP:WP2516 | ATM signaling | ATM signaling | 15 | 2.045291e-13 | 0 |
| WP | WP:WP5180 | DYRK1A involvement regarding cell proliferation in brain development | DYRK1A involvement regarding cell proliferation in brain development | 18 | 2.471332e-13 | 0 |
| WP | WP:WP1984 | Integrated breast cancer pathway | Integrated breast cancer pathway | 24 | 1.102348e-11 | 0 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 19 | 6.651400e-11 | 0 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 16 | 7.997233e-09 | 0 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 37 | 4.477055e-08 | 0 |
| WP | WP:WP3878 | ATM signaling in development and disease | ATM signaling in development and disease | 12 | 8.822536e-08 | 0 |
| WP | WP:WP53 | ID signaling | ID signaling | 8 | 1.631359e-07 | 0 |
| WP | WP:WP5114 | Nucleotide excision repair in xeroderma pigmentosum | Nucleotide excision repair in xeroderma pigmentosum | 14 | 2.160584e-07 | 0 |
| WP | WP:WP4753 | Nucleotide excision repair | Nucleotide excision repair | 11 | 4.753167e-07 | 0 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 14 | 2.297260e-06 | 0 |
| WP | WP:WP4262 | Breast cancer pathway | Breast cancer pathway | 18 | 2.765457e-06 | 0 |
| WP | WP:WP531 | DNA mismatch repair | DNA mismatch repair | 8 | 5.411391e-06 | 0 |
| WP | WP:WP236 | Adipogenesis | Adipogenesis | 16 | 8.835876e-06 | 0 |
| WP | WP:WP4879 | Overlap between signal transduction pathways contributing to LMNA laminopathies | Overlap between signal transduction pathways contributing to LMNA laminopathies | 11 | 1.150872e-05 | 0 |
| WP | WP:WP5118 | SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome | SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome | 6 | 1.259735e-05 | 0 |
| WP | WP:WP138 | Androgen receptor signaling | Androgen receptor signaling | 13 | 1.277941e-05 | 0 |
| WP | WP:WP4630 | Measles virus infection | Measles virus infection | 16 | 1.684020e-05 | 0 |
| WP | WP:WP4216 | Chromosomal and microsatellite instability in colorectal cancer | Chromosomal and microsatellite instability in colorectal cancer | 12 | 1.838907e-05 | 0 |
| WP | WP:WP186 | Homologous recombination | Homologous recombination | 6 | 4.502185e-05 | 0 |
| WP | WP:WP2431 | Spinal cord injury | Spinal cord injury | 14 | 7.372013e-05 | 0 |
| WP | WP:WP5158 | Urotensin II mediated signaling | Urotensin II mediated signaling | 11 | 8.940545e-05 | 0 |
| WP | WP:WP3646 | Hepatitis C and hepatocellular carcinoma | Hepatitis C and hepatocellular carcinoma | 10 | 1.020164e-04 | 0 |
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 13 | 3.410193e-04 | 0 |
| WP | WP:WP4963 | p53 transcriptional gene network | p53 transcriptional gene network | 12 | 3.933243e-04 | 0 |
| WP | WP:WP5497 | Cyclin dependent kinase 4 6 inhibitors in breast cancer | Cyclin dependent kinase 4 6 inhibitors in breast cancer | 8 | 4.013700e-04 | 0 |
| WP | WP:WP2361 | Gastric cancer network 1 | Gastric cancer network 1 | 7 | 5.256877e-04 | 0 |
| WP | WP:WP5527 | NF kB signaling and ARTD family members | NF kB signaling and ARTD family members | 7 | 5.256877e-04 | 0 |
| WP | WP:WP5144 | NRP1 triggered signaling in pancreatic cancer | NRP1 triggered signaling in pancreatic cancer | 9 | 6.048408e-04 | 0 |
| WP | WP:WP405 | Eukaryotic transcription initiation | Eukaryotic transcription initiation | 8 | 7.391663e-04 | 0 |
| WP | WP:WP3657 | Hematopoietic stem cell gene regulation by GABP alpha beta complex | Hematopoietic stem cell gene regulation by GABP alpha beta complex | 6 | 8.888235e-04 | 0 |
| WP | WP:WP4752 | Base excision repair | Base excision repair | 7 | 1.101124e-03 | 0 |
| WP | WP:WP3981 | miRNA regulation of prostate cancer signaling | miRNA regulation of prostate cancer signaling | 7 | 1.101124e-03 | 0 |
| WP | WP:WP4255 | Non small cell lung cancer | Non small cell lung cancer | 10 | 1.116002e-03 | 0 |
| WP | WP:WP5103 | Progeria associated lipodystrophy | Progeria associated lipodystrophy | 6 | 1.646509e-03 | 0 |
| WP | WP:WP3391 | Senescence associated secretory phenotype SASP | Senescence associated secretory phenotype SASP | 12 | 2.016225e-03 | 0 |
| WP | WP:WP3611 | Photodynamic therapy induced AP 1 survival signaling | Photodynamic therapy induced AP 1 survival signaling | 8 | 3.478751e-03 | 0 |
| WP | WP:WP4685 | Melanoma | Melanoma | 9 | 4.994634e-03 | 0 |
| WP | WP:WP1545 | miRNAs involved in DNA damage response | miRNAs involved in DNA damage response | 9 | 4.994634e-03 | 0 |
| WP | WP:WP615 | Senescence and autophagy in cancer | Senescence and autophagy in cancer | 11 | 5.935955e-03 | 0 |
| WP | WP:WP4673 | Male infertility | Male infertility | 13 | 5.968232e-03 | 0 |
| WP | WP:WP710 | DNA damage response only ATM dependent | DNA damage response only ATM dependent | 11 | 8.438734e-03 | 0 |
| WP | WP:WP4674 | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | 9 | 9.946488e-03 | 0 |
| WP | WP:WP2032 | Thyroid stimulating hormone TSH signaling | Thyroid stimulating hormone TSH signaling | 8 | 1.061243e-02 | 0 |
| WP | WP:WP438 | Non homologous end joining | Non homologous end joining | 4 | 1.120688e-02 | 0 |
| WP | WP:WP5300 | TROP2 regulatory signaling | TROP2 regulatory signaling | 7 | 1.245917e-02 | 0 |
| WP | WP:WP2586 | Aryl hydrocarbon receptor pathway | Aryl hydrocarbon receptor pathway | 7 | 1.673931e-02 | 0 |
| WP | WP:WP5465 | Fanconi anemia | Fanconi anemia | 7 | 1.929043e-02 | 0 |
| WP | WP:WP5477 | Molecular pathway for oxidative stress | Molecular pathway for oxidative stress | 7 | 2.534463e-02 | 0 |
| WP | WP:WP5046 | NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence | NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence | 5 | 2.564360e-02 | 0 |
| WP | WP:WP254 | Apoptosis | Apoptosis | 9 | 3.569293e-02 | 0 |
| WP | WP:WP4211 | Transcriptional cascade regulating adipogenesis | Transcriptional cascade regulating adipogenesis | 4 | 3.614089e-02 | 0 |
| WP | WP:WP5366 | NF1 copy number variation syndrome | NF1 copy number variation syndrome | 10 | 3.641652e-02 | 0 |
| WP | WP:WP4666 | Hepatitis B infection | Hepatitis B infection | 12 | 4.160031e-02 | 0 |
| WP | WP:WP4874 | CAMKK2 pathway | CAMKK2 pathway | 10 | 4.579161e-02 | 0 |
| WP | WP:WP3969 | H19 Rb E2F1 and CDK beta catenin in colorectal cancer | H19 Rb E2F1 and CDK beta catenin in colorectal cancer | 4 | 4.969131e-02 | 0 |
| WP | WP:WP4240 | Regulation of sister chromatid separation at the metaphase anaphase transition | Regulation of sister chromatid separation at the metaphase anaphase transition | 4 | 4.969131e-02 | 0 |
| WP | WP:WP4399 | MicroRNA network associated with chronic lymphocytic leukemia | MicroRNA network associated with chronic lymphocytic leukemia | 3 | 4.995742e-02 | 0 |
| WP | WP:WP3672 | lncRNA mediated mechanisms of therapeutic resistance | lncRNA mediated mechanisms of therapeutic resistance | 3 | 4.995742e-02 | 0 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 62 | 3.940670e-64 | 0 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 36 | 2.389580e-26 | 0 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 31 | 8.517624e-16 | 0 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 25 | 1.248713e-15 | 0 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 29 | 7.322074e-15 | 0 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | Progesterone-mediated oocyte maturation | 21 | 1.157732e-13 | 0 |
| KEGG | KEGG:04115 | p53 signaling pathway | p53 signaling pathway | 17 | 1.007863e-11 | 0 |
| KEGG | KEGG:03030 | DNA replication | DNA replication | 13 | 1.379469e-11 | 0 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 18 | 3.598861e-11 | 0 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 38 | 7.982039e-10 | 0 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 22 | 1.080847e-08 | 0 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 20 | 1.198871e-08 | 0 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 14 | 3.915713e-08 | 0 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 15 | 1.182128e-07 | 0 |
| KEGG | KEGG:04068 | FoxO signaling pathway | FoxO signaling pathway | 17 | 1.466903e-07 | 0 |
| KEGG | KEGG:03450 | Non-homologous end-joining | Non-homologous end-joining | 7 | 2.345980e-07 | 0 |
| KEGG | KEGG:03420 | Nucleotide excision repair | Nucleotide excision repair | 12 | 3.332224e-07 | 0 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 13 | 4.411398e-07 | 0 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | TGF-beta signaling pathway | 15 | 4.804516e-07 | 0 |
| KEGG | KEGG:03430 | Mismatch repair | Mismatch repair | 8 | 1.143422e-06 | 0 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | MicroRNAs in cancer | 24 | 2.340684e-06 | 0 |
| KEGG | KEGG:05162 | Measles | Measles | 16 | 2.375270e-06 | 0 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 16 | 6.464815e-06 | 0 |
| KEGG | KEGG:03440 | Homologous recombination | Homologous recombination | 9 | 1.198001e-05 | 0 |
| KEGG | KEGG:03410 | Base excision repair | Base excision repair | 9 | 2.297099e-05 | 0 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 23 | 3.200928e-05 | 0 |
| KEGG | KEGG:01522 | Endocrine resistance | Endocrine resistance | 12 | 5.644516e-05 | 0 |
| KEGG | KEGG:05210 | Colorectal cancer | Colorectal cancer | 11 | 1.494506e-04 | 0 |
| KEGG | KEGG:05219 | Bladder cancer | Bladder cancer | 8 | 1.616559e-04 | 0 |
| KEGG | KEGG:04934 | Cushing syndrome | Cushing syndrome | 14 | 3.369143e-04 | 0 |
| KEGG | KEGG:05218 | Melanoma | Melanoma | 9 | 1.669728e-03 | 0 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | Non-small cell lung cancer | 9 | 1.669728e-03 | 0 |
| KEGG | KEGG:05214 | Glioma | Glioma | 9 | 2.335155e-03 | 0 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 13 | 2.412591e-03 | 0 |
| KEGG | KEGG:03022 | Basal transcription factors | Basal transcription factors | 7 | 2.595648e-03 | 0 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | Hepatocellular carcinoma | 13 | 4.066830e-03 | 0 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | Transcriptional misregulation in cancer | 14 | 4.528513e-03 | 0 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | Kaposi sarcoma-associated herpesvirus infection | 14 | 5.074848e-03 | 0 |
| KEGG | KEGG:05224 | Breast cancer | Breast cancer | 12 | 5.398208e-03 | 0 |
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 12 | 1.022799e-02 | 0 |
| KEGG | KEGG:01524 | Platinum drug resistance | Platinum drug resistance | 8 | 1.167614e-02 | 0 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | 19 | 1.499834e-02 | 0 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | AGE-RAGE signaling pathway in diabetic complications | 9 | 2.263129e-02 | 0 |
| KEGG | KEGG:04310 | Wnt signaling pathway | Wnt signaling pathway | 12 | 2.697065e-02 | 0 |
| KEGG | KEGG:03083 | Polycomb repressive complex | Polycomb repressive complex | 8 | 3.439151e-02 | 0 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | Acute myeloid leukemia | 7 | 4.599303e-02 | 0 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 94 | 5.164195e-58 | 0 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 83 | 3.987836e-53 | 0 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 51 | 4.897679e-50 | 0 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 50 | 3.427979e-46 | 0 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 44 | 4.348042e-42 | 0 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 27 | 6.215992e-33 | 0 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 27 | 6.215992e-33 | 0 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 48 | 6.886372e-26 | 0 |
| REAC | REAC:R-HSA-1538133 | G0 and Early G1 | G0 and Early G1 | 19 | 1.047512e-25 | 0 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 91 | 3.621472e-25 | 0 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 82 | 5.427721e-25 | 0 |
| REAC | REAC:R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 16 | 6.338851e-25 | 0 |
| REAC | REAC:R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 16 | 6.338851e-25 | 0 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 84 | 1.225511e-23 | 0 |
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 20 | 1.672652e-23 | 0 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 18 | 4.338954e-23 | 0 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 20 | 7.445923e-23 | 0 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 26 | 7.735751e-23 | 0 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 29 | 3.894560e-22 | 0 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 25 | 1.056241e-21 | 0 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 40 | 1.150301e-21 | 0 |
| REAC | REAC:R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | TP53 Regulates Transcription of Cell Cycle Genes | 21 | 1.219642e-21 | 0 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 32 | 8.924980e-20 | 0 |
| REAC | REAC:R-HSA-73894 | DNA Repair | DNA Repair | 40 | 1.631501e-19 | 0 |
| REAC | REAC:R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | Cyclin A/B1/B2 associated events during G2/M transition | 15 | 1.450392e-17 | 0 |
| REAC | REAC:R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 12 | 1.939818e-16 | 0 |
| REAC | REAC:R-HSA-68962 | Activation of the pre-replicative complex | Activation of the pre-replicative complex | 15 | 1.740704e-15 | 0 |
| REAC | REAC:R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 12 | 7.543579e-15 | 0 |
| REAC | REAC:R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | Transcription of E2F targets under negative control by DREAM complex | 12 | 7.543579e-15 | 0 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 26 | 1.193543e-14 | 0 |
| REAC | REAC:R-HSA-5693532 | DNA Double-Strand Break Repair | DNA Double-Strand Break Repair | 26 | 1.879982e-14 | 0 |
| REAC | REAC:R-HSA-156711 | Polo-like kinase mediated events | Polo-like kinase mediated events | 11 | 3.313962e-14 | 0 |
| REAC | REAC:R-HSA-69190 | DNA strand elongation | DNA strand elongation | 14 | 4.649062e-14 | 0 |
| REAC | REAC:R-HSA-5633007 | Regulation of TP53 Activity | Regulation of TP53 Activity | 25 | 4.663221e-14 | 0 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 81 | 4.807067e-13 | 0 |
| REAC | REAC:R-HSA-2559583 | Cellular Senescence | Cellular Senescence | 26 | 5.199329e-13 | 0 |
| REAC | REAC:R-HSA-176187 | Activation of ATR in response to replication stress | Activation of ATR in response to replication stress | 14 | 5.559128e-13 | 0 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 19 | 1.276029e-12 | 0 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 25 | 7.868073e-12 | 0 |
| REAC | REAC:R-HSA-113510 | E2F mediated regulation of DNA replication | E2F mediated regulation of DNA replication | 11 | 2.888968e-11 | 0 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 48 | 6.157018e-11 | 0 |
| REAC | REAC:R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 14 | 6.932554e-11 | 0 |
| REAC | REAC:R-HSA-180786 | Extension of Telomeres | Extension of Telomeres | 14 | 9.403871e-11 | 0 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 47 | 1.347320e-10 | 0 |
| REAC | REAC:R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 9 | 1.577773e-10 | 0 |
| REAC | REAC:R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Regulation of TP53 Activity through Phosphorylation | 17 | 2.715651e-10 | 0 |
| REAC | REAC:R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 12 | 3.813765e-10 | 0 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 23 | 4.539677e-10 | 0 |
| REAC | REAC:R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | Global Genome Nucleotide Excision Repair (GG-NER) | 16 | 8.159214e-10 | 0 |
| REAC | REAC:R-HSA-5696398 | Nucleotide Excision Repair | Nucleotide Excision Repair | 17 | 3.518188e-09 | 0 |
| REAC | REAC:R-HSA-2559585 | Oncogene Induced Senescence | Oncogene Induced Senescence | 11 | 3.525186e-09 | 0 |
| REAC | REAC:R-HSA-5693538 | Homology Directed Repair | Homology Directed Repair | 19 | 3.550016e-09 | 0 |
| REAC | REAC:R-HSA-69186 | Lagging Strand Synthesis | Lagging Strand Synthesis | 9 | 1.203741e-08 | 0 |
| REAC | REAC:R-HSA-69002 | DNA Replication Pre-Initiation | DNA Replication Pre-Initiation | 19 | 3.450581e-08 | 0 |
| REAC | REAC:R-HSA-170834 | Signaling by TGF-beta Receptor Complex | Signaling by TGF-beta Receptor Complex | 15 | 4.275677e-08 | 0 |
| REAC | REAC:R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | DNA Damage/Telomere Stress Induced Senescence | 14 | 5.780246e-08 | 0 |
| REAC | REAC:R-HSA-9614085 | FOXO-mediated transcription | FOXO-mediated transcription | 13 | 6.731838e-08 | 0 |
| REAC | REAC:R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins | SUMO E3 ligases SUMOylate target proteins | 19 | 1.362853e-07 | 0 |
| REAC | REAC:R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 17 | 1.389089e-07 | 0 |
| REAC | REAC:R-HSA-5685942 | HDR through Homologous Recombination (HRR) | HDR through Homologous Recombination (HRR) | 13 | 1.465671e-07 | 0 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 13 | 1.765691e-07 | 0 |
| REAC | REAC:R-HSA-2990846 | SUMOylation | SUMOylation | 19 | 2.462921e-07 | 0 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 12 | 2.904864e-07 | 0 |
| REAC | REAC:R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | Gap-filling DNA repair synthesis and ligation in TC-NER | 12 | 3.558910e-07 | 0 |
| REAC | REAC:R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 13 | 3.608535e-07 | 0 |
| REAC | REAC:R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 7 | 8.480125e-07 | 0 |
| REAC | REAC:R-HSA-69091 | Polymerase switching | Polymerase switching | 7 | 8.480125e-07 | 0 |
| REAC | REAC:R-HSA-69109 | Leading Strand Synthesis | Leading Strand Synthesis | 7 | 8.480125e-07 | 0 |
| REAC | REAC:R-HSA-69478 | G2/M DNA replication checkpoint | G2/M DNA replication checkpoint | 5 | 8.719657e-07 | 0 |
| REAC | REAC:R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | Drug-mediated inhibition of CDK4/CDK6 activity | 5 | 8.719657e-07 | 0 |
| REAC | REAC:R-HSA-68911 | G2 Phase | G2 Phase | 5 | 8.719657e-07 | 0 |
| REAC | REAC:R-HSA-69183 | Processive synthesis on the lagging strand | Processive synthesis on the lagging strand | 7 | 1.565509e-06 | 0 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 23 | 2.212498e-06 | 0 |
| REAC | REAC:R-HSA-9006936 | Signaling by TGFB family members | Signaling by TGFB family members | 15 | 2.484886e-06 | 0 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 13 | 2.779336e-06 | 0 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 13 | 2.779336e-06 | 0 |
| REAC | REAC:R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | Telomere C-strand (Lagging Strand) Synthesis | 9 | 3.012369e-06 | 0 |
| REAC | REAC:R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 8 | 4.024612e-06 | 0 |
| REAC | REAC:R-HSA-8849470 | PTK6 Regulates Cell Cycle | PTK6 Regulates Cell Cycle | 5 | 5.154103e-06 | 0 |
| REAC | REAC:R-HSA-6782135 | Dual incision in TC-NER | Dual incision in TC-NER | 11 | 5.829405e-06 | 0 |
| REAC | REAC:R-HSA-157579 | Telomere Maintenance | Telomere Maintenance | 14 | 5.849750e-06 | 0 |
| REAC | REAC:R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | HDR through MMEJ (alt-NHEJ) | 6 | 1.309765e-05 | 0 |
| REAC | REAC:R-HSA-73886 | Chromosome Maintenance | Chromosome Maintenance | 15 | 1.360286e-05 | 0 |
| REAC | REAC:R-HSA-5696400 | Dual Incision in GG-NER | Dual Incision in GG-NER | 9 | 1.801375e-05 | 0 |
| REAC | REAC:R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | PCNA-Dependent Long Patch Base Excision Repair | 7 | 2.577208e-05 | 0 |
| REAC | REAC:R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 6 | 4.128538e-05 | 0 |
| REAC | REAC:R-HSA-69166 | Removal of the Flap Intermediate | Removal of the Flap Intermediate | 6 | 4.128538e-05 | 0 |
| REAC | REAC:R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 6 | 4.128538e-05 | 0 |
| REAC | REAC:R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | 4 | 4.868844e-05 | 0 |
| REAC | REAC:R-HSA-69473 | G2/M DNA damage checkpoint | G2/M DNA damage checkpoint | 12 | 5.757896e-05 | 0 |
| REAC | REAC:R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | TP53 Regulates Transcription of DNA Repair Genes | 10 | 5.971296e-05 | 0 |
| REAC | REAC:R-HSA-73762 | RNA Polymerase I Transcription Initiation | RNA Polymerase I Transcription Initiation | 9 | 6.372941e-05 | 0 |
| REAC | REAC:R-HSA-5358508 | Mismatch Repair | Mismatch Repair | 6 | 6.776530e-05 | 0 |
| REAC | REAC:R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | Impaired BRCA2 binding to PALB2 | 7 | 7.322107e-05 | 0 |
| REAC | REAC:R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | Impaired BRCA2 binding to RAD51 | 8 | 7.486639e-05 | 0 |
| REAC | REAC:R-HSA-73933 | Resolution of Abasic Sites (AP sites) | Resolution of Abasic Sites (AP sites) | 8 | 9.476006e-05 | 0 |
| REAC | REAC:R-HSA-6804757 | Regulation of TP53 Degradation | Regulation of TP53 Degradation | 8 | 9.476006e-05 | 0 |
| REAC | REAC:R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | Resolution of D-loop Structures through Holliday Junction Intermediates | 8 | 9.476006e-05 | 0 |
| REAC | REAC:R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 7 | 1.001308e-04 | 0 |
| REAC | REAC:R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 7 | 1.001308e-04 | 0 |
| REAC | REAC:R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | 7 | 1.001308e-04 | 0 |
| REAC | REAC:R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | 7 | 1.001308e-04 | 0 |
| REAC | REAC:R-HSA-139915 | Activation of PUMA and translocation to mitochondria | Activation of PUMA and translocation to mitochondria | 5 | 1.034889e-04 | 0 |
| REAC | REAC:R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | Initiation of Nuclear Envelope (NE) Reformation | 6 | 1.067803e-04 | 0 |
| REAC | REAC:R-HSA-9675135 | Diseases of DNA repair | Diseases of DNA repair | 9 | 1.117560e-04 | 0 |
| REAC | REAC:R-HSA-6806003 | Regulation of TP53 Expression and Degradation | Regulation of TP53 Expression and Degradation | 8 | 1.190211e-04 | 0 |
| REAC | REAC:R-HSA-5693537 | Resolution of D-Loop Structures | Resolution of D-Loop Structures | 8 | 1.190211e-04 | 0 |
| REAC | REAC:R-HSA-174411 | Polymerase switching on the C-strand of the telomere | Polymerase switching on the C-strand of the telomere | 7 | 1.349127e-04 | 0 |
| REAC | REAC:R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | FOXO-mediated transcription of cell cycle genes | 6 | 1.625224e-04 | 0 |
| REAC | REAC:R-HSA-162587 | HIV Life Cycle | HIV Life Cycle | 14 | 1.759024e-04 | 0 |
| REAC | REAC:R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 7 | 1.793301e-04 | 0 |
| REAC | REAC:R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | Presynaptic phase of homologous DNA pairing and strand exchange | 8 | 2.261983e-04 | 0 |
| REAC | REAC:R-HSA-111448 | Activation of NOXA and translocation to mitochondria | Activation of NOXA and translocation to mitochondria | 4 | 2.399543e-04 | 0 |
| REAC | REAC:R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | Diseases of DNA Double-Strand Break Repair | 8 | 2.766672e-04 | 0 |
| REAC | REAC:R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 8 | 2.766672e-04 | 0 |
| REAC | REAC:R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | Senescence-Associated Secretory Phenotype (SASP) | 12 | 3.624690e-04 | 0 |
| REAC | REAC:R-HSA-2514853 | Condensation of Prometaphase Chromosomes | Condensation of Prometaphase Chromosomes | 5 | 3.682908e-04 | 0 |
| REAC | REAC:R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | Homologous DNA Pairing and Strand Exchange | 8 | 4.069382e-04 | 0 |
| REAC | REAC:R-HSA-176974 | Unwinding of DNA | Unwinding of DNA | 5 | 6.220001e-04 | 0 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 23 | 6.422512e-04 | 0 |
| REAC | REAC:R-HSA-5693607 | Processing of DNA double-strand break ends | Processing of DNA double-strand break ends | 11 | 6.532909e-04 | 0 |
| REAC | REAC:R-HSA-5693548 | Sensing of DNA Double Strand Breaks | Sensing of DNA Double Strand Breaks | 4 | 7.095548e-04 | 0 |
| REAC | REAC:R-HSA-68867 | Assembly of the pre-replicative complex | Assembly of the pre-replicative complex | 13 | 8.490869e-04 | 0 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 10 | 9.057314e-04 | 0 |
| REAC | REAC:R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | Golgi Cisternae Pericentriolar Stack Reorganization | 5 | 9.957783e-04 | 0 |
| REAC | REAC:R-HSA-5689880 | Ub-specific processing proteases | Ub-specific processing proteases | 16 | 1.262749e-03 | 0 |
| REAC | REAC:R-HSA-162594 | Early Phase of HIV Life Cycle | Early Phase of HIV Life Cycle | 5 | 1.526052e-03 | 0 |
| REAC | REAC:R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | Defective Intrinsic Pathway for Apoptosis | 6 | 1.588446e-03 | 0 |
| REAC | REAC:R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | APC/C:Cdc20 mediated degradation of Cyclin B | 6 | 1.588446e-03 | 0 |
| REAC | REAC:R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | RUNX3 regulates CDKN1A transcription | 4 | 1.631932e-03 | 0 |
| REAC | REAC:R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | Nonhomologous End-Joining (NHEJ) | 9 | 1.654938e-03 | 0 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 9 | 1.654938e-03 | 0 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 16 | 1.688253e-03 | 0 |
| REAC | REAC:R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | HDR through Single Strand Annealing (SSA) | 7 | 1.780768e-03 | 0 |
| REAC | REAC:R-HSA-68882 | Mitotic Anaphase | Mitotic Anaphase | 16 | 1.891716e-03 | 0 |
| REAC | REAC:R-HSA-2555396 | Mitotic Metaphase and Anaphase | Mitotic Metaphase and Anaphase | 16 | 2.001474e-03 | 0 |
| REAC | REAC:R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | Gap-filling DNA repair synthesis and ligation in GG-NER | 6 | 2.058440e-03 | 0 |
| REAC | REAC:R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 5 | 2.255195e-03 | 0 |
| REAC | REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | Intrinsic Pathway for Apoptosis | 8 | 2.458276e-03 | 0 |
| REAC | REAC:R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | Loss of Function of SMAD4 in Cancer | 3 | 2.705159e-03 | 0 |
| REAC | REAC:R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | SMAD2/3 MH2 Domain Mutants in Cancer | 3 | 2.705159e-03 | 0 |
| REAC | REAC:R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | SMAD4 MH2 Domain Mutants in Cancer | 3 | 2.705159e-03 | 0 |
| REAC | REAC:R-HSA-1912408 | Pre-NOTCH Transcription and Translation | Pre-NOTCH Transcription and Translation | 10 | 2.920865e-03 | 0 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 9 | 3.013334e-03 | 0 |
| REAC | REAC:R-HSA-9614657 | FOXO-mediated transcription of cell death genes | FOXO-mediated transcription of cell death genes | 5 | 3.231748e-03 | 0 |
| REAC | REAC:R-HSA-212165 | Epigenetic regulation of gene expression | Epigenetic regulation of gene expression | 14 | 3.242090e-03 | 0 |
| REAC | REAC:R-HSA-1500620 | Meiosis | Meiosis | 11 | 3.816280e-03 | 0 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 11 | 4.500002e-03 | 0 |
| REAC | REAC:R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | Regulation of RUNX1 Expression and Activity | 5 | 4.510592e-03 | 0 |
| REAC | REAC:R-HSA-5696395 | Formation of Incision Complex in GG-NER | Formation of Incision Complex in GG-NER | 7 | 5.079788e-03 | 0 |
| REAC | REAC:R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 6 | 5.194776e-03 | 0 |
| REAC | REAC:R-HSA-5693606 | DNA Double Strand Break Response | DNA Double Strand Break Response | 9 | 5.231979e-03 | 0 |
| REAC | REAC:R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | E2F-enabled inhibition of pre-replication complex formation | 4 | 5.708128e-03 | 0 |
| REAC | REAC:R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | Formation of HIV elongation complex in the absence of HIV Tat | 7 | 5.948194e-03 | 0 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 6 | 6.395361e-03 | 0 |
| REAC | REAC:R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | Recognition of DNA damage by PCNA-containing replication complex | 6 | 6.395361e-03 | 0 |
| REAC | REAC:R-HSA-73863 | RNA Polymerase I Transcription Termination | RNA Polymerase I Transcription Termination | 6 | 7.810464e-03 | 0 |
| REAC | REAC:R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | NOTCH1 Intracellular Domain Regulates Transcription | 7 | 8.055424e-03 | 0 |
| REAC | REAC:R-HSA-174414 | Processive synthesis on the C-strand of the telomere | Processive synthesis on the C-strand of the telomere | 5 | 8.227204e-03 | 0 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 34 | 8.474241e-03 | 0 |
| REAC | REAC:R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | Cytosolic sensors of pathogen-associated DNA | 8 | 8.945326e-03 | 0 |
| REAC | REAC:R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | Regulation of FOXO transcriptional activity by acetylation | 4 | 9.377607e-03 | 0 |
| REAC | REAC:R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | Nuclear events stimulated by ALK signaling in cancer | 6 | 9.467717e-03 | 0 |
| REAC | REAC:R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 5 | 1.080754e-02 | 0 |
| REAC | REAC:R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | NOTCH4 Intracellular Domain Regulates Transcription | 5 | 1.080754e-02 | 0 |
| REAC | REAC:R-HSA-176412 | Phosphorylation of the APC/C | Phosphorylation of the APC/C | 5 | 1.080754e-02 | 0 |
| REAC | REAC:R-HSA-8878171 | Transcriptional regulation by RUNX1 | Transcriptional regulation by RUNX1 | 15 | 1.120252e-02 | 0 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 8 | 1.125113e-02 | 0 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 8 | 1.125113e-02 | 0 |
| REAC | REAC:R-HSA-1912422 | Pre-NOTCH Expression and Processing | Pre-NOTCH Expression and Processing | 10 | 1.217734e-02 | 0 |
| REAC | REAC:R-HSA-9616222 | Transcriptional regulation of granulopoiesis | Transcriptional regulation of granulopoiesis | 9 | 1.277297e-02 | 0 |
| REAC | REAC:R-HSA-73854 | RNA Polymerase I Promoter Clearance | RNA Polymerase I Promoter Clearance | 10 | 1.319705e-02 | 0 |
| REAC | REAC:R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | 5 | 1.397539e-02 | 0 |
| REAC | REAC:R-HSA-8863678 | Neurodegenerative Diseases | Neurodegenerative Diseases | 5 | 1.397539e-02 | 0 |
| REAC | REAC:R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | Formation of TC-NER Pre-Incision Complex | 7 | 1.413223e-02 | 0 |
| REAC | REAC:R-HSA-73864 | RNA Polymerase I Transcription | RNA Polymerase I Transcription | 10 | 1.428905e-02 | 0 |
| REAC | REAC:R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | NFE2L2 regulating tumorigenic genes | 4 | 1.452579e-02 | 0 |
| REAC | REAC:R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | Signaling by ALK fusions and activated point mutants | 9 | 1.533890e-02 | 0 |
| REAC | REAC:R-HSA-9700206 | Signaling by ALK in cancer | Signaling by ALK in cancer | 9 | 1.533890e-02 | 0 |
| REAC | REAC:R-HSA-167172 | Transcription of the HIV genome | Transcription of the HIV genome | 8 | 1.563046e-02 | 0 |
| REAC | REAC:R-HSA-9730414 | MITF-M-regulated melanocyte development | MITF-M-regulated melanocyte development | 10 | 1.670677e-02 | 0 |
| REAC | REAC:R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | Nuclear Envelope (NE) Reassembly | 8 | 1.737423e-02 | 0 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 47 | 2.219997e-02 | 0 |
| REAC | REAC:R-HSA-171319 | Telomere Extension By Telomerase | Telomere Extension By Telomerase | 5 | 2.243245e-02 | 0 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 9 | 2.580395e-02 | 0 |
| REAC | REAC:R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 6 | 2.632876e-02 | 0 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 21 | 2.751731e-02 | 0 |
| REAC | REAC:R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 4 | 3.058075e-02 | 0 |
| REAC | REAC:R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 4 | 3.058075e-02 | 0 |
| REAC | REAC:R-HSA-3270619 | IRF3-mediated induction of type I IFN | IRF3-mediated induction of type I IFN | 4 | 3.058075e-02 | 0 |
| REAC | REAC:R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | APC/C:Cdc20 mediated degradation of mitotic proteins | 8 | 3.160471e-02 | 0 |
| REAC | REAC:R-HSA-112382 | Formation of RNA Pol II elongation complex | Formation of RNA Pol II elongation complex | 7 | 3.357894e-02 | 0 |
| REAC | REAC:R-HSA-75955 | RNA Polymerase II Transcription Elongation | RNA Polymerase II Transcription Elongation | 7 | 3.357894e-02 | 0 |
| REAC | REAC:R-HSA-68877 | Mitotic Prometaphase | Mitotic Prometaphase | 13 | 3.412708e-02 | 0 |
| REAC | REAC:R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | 8 | 3.472390e-02 | 0 |
| REAC | REAC:R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 8 | 3.472390e-02 | 0 |
| REAC | REAC:R-HSA-9018519 | Estrogen-dependent gene expression | Estrogen-dependent gene expression | 11 | 3.509410e-02 | 0 |
| REAC | REAC:R-HSA-157118 | Signaling by NOTCH | Signaling by NOTCH | 14 | 3.854187e-02 | 0 |
| REAC | REAC:R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | Resolution of Sister Chromatid Cohesion | 10 | 3.985246e-02 | 0 |
| REAC | REAC:R-HSA-3899300 | SUMOylation of transcription cofactors | SUMOylation of transcription cofactors | 6 | 4.097296e-02 | 0 |
| REAC | REAC:R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 5 | 4.194136e-02 | 0 |
| REAC | REAC:R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | RNA Pol II CTD phosphorylation and interaction with CE | 5 | 4.194136e-02 | 0 |
| REAC | REAC:R-HSA-8941856 | RUNX3 regulates NOTCH signaling | RUNX3 regulates NOTCH signaling | 4 | 4.220263e-02 | 0 |
| REAC | REAC:R-HSA-9856651 | MITF-M-dependent gene expression | MITF-M-dependent gene expression | 8 | 4.565233e-02 | 0 |
| REAC | REAC:R-HSA-674695 | RNA Polymerase II Pre-transcription Events | RNA Polymerase II Pre-transcription Events | 8 | 4.565233e-02 | 0 |
| REAC | REAC:R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | Nuclear Events (kinase and transcription factor activation) | 7 | 4.683569e-02 | 0 |
| REAC | REAC:R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | Formation of HIV-1 elongation complex containing HIV-1 Tat | 6 | 4.708194e-02 | 0 |
| REAC | REAC:R-HSA-167169 | HIV Transcription Elongation | HIV Transcription Elongation | 6 | 4.708194e-02 | 0 |
| REAC | REAC:R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | Tat-mediated elongation of the HIV-1 transcript | 6 | 4.708194e-02 | 0 |
| REAC | REAC:R-HSA-9645723 | Diseases of programmed cell death | Diseases of programmed cell death | 9 | 4.861102e-02 | 0 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 32 | 3.661791e-39 | 0 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 32 | 3.661791e-39 | 0 |
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 27 | 6.965126e-37 | 0 |
| GO:MF | GO:0003682 | chromatin binding | "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] | 61 | 4.886663e-34 | 0 |
| GO:MF | GO:0003677 | DNA binding | "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] | 104 | 5.909610e-28 | 0 |
| GO:MF | GO:0008134 | transcription factor binding | "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] | 49 | 1.576481e-23 | 0 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 47 | 4.847069e-23 | 0 |
| GO:MF | GO:0140297 | DNA-binding transcription factor binding | "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] | 44 | 1.391673e-22 | 0 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 86 | 7.554111e-22 | 0 |
| GO:MF | GO:0140097 | catalytic activity, acting on DNA | "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] | 33 | 4.265055e-21 | 0 |
| GO:MF | GO:0019887 | protein kinase regulator activity | "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] | 32 | 4.471494e-21 | 0 |
| GO:MF | GO:0016772 | transferase activity, transferring phosphorus-containing groups | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] | 61 | 1.968448e-19 | 0 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 244 | 2.392396e-19 | 0 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 50 | 3.585360e-19 | 0 |
| GO:MF | GO:0019207 | kinase regulator activity | "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] | 32 | 4.469244e-19 | 0 |
| GO:MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] | 50 | 1.588229e-16 | 0 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 52 | 3.614196e-16 | 0 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 90 | 1.814119e-15 | 0 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 45 | 5.021791e-15 | 0 |
| GO:MF | GO:0016740 | transferase activity | "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-] | 83 | 3.177748e-14 | 0 |
| GO:MF | GO:0003690 | double-stranded DNA binding | "Binding to double-stranded DNA." [GOC:elh, GOC:vw] | 63 | 1.484921e-13 | 0 |
| GO:MF | GO:0008094 | ATP-dependent activity, acting on DNA | "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] | 19 | 5.129434e-13 | 0 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 40 | 6.368227e-13 | 0 |
| GO:MF | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity | "Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810] | 9 | 5.215988e-12 | 0 |
| GO:MF | GO:0003678 | DNA helicase activity | "Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl] | 14 | 5.334106e-12 | 0 |
| GO:MF | GO:0043565 | sequence-specific DNA binding | "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] | 60 | 1.159505e-11 | 0 |
| GO:MF | GO:0140640 | catalytic activity, acting on a nucleic acid | "Catalytic activity that acts to modify a nucleic acid." [GOC:pg] | 36 | 1.922404e-11 | 0 |
| GO:MF | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] | 26 | 1.210683e-10 | 0 |
| GO:MF | GO:0140110 | transcription regulator activity | "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] | 64 | 1.297661e-10 | 0 |
| GO:MF | GO:0120545 | nucleic acid conformation isomerase activity | "Catalysis of a reaction that alters the conformation of a nucleic acid." [EC:5.6.2.-] | 19 | 1.675354e-10 | 0 |
| GO:MF | GO:1990837 | sequence-specific double-stranded DNA binding | "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] | 55 | 3.784272e-10 | 0 |
| GO:MF | GO:0043539 | protein serine/threonine kinase activator activity | "Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators] | 13 | 1.163244e-09 | 0 |
| GO:MF | GO:0003712 | transcription coregulator activity | "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] | 29 | 1.754374e-09 | 0 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 118 | 3.002219e-09 | 0 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 33 | 3.928080e-09 | 0 |
| GO:MF | GO:0003684 | damaged DNA binding | "Binding to damaged DNA." [GOC:jl] | 13 | 4.255180e-09 | 0 |
| GO:MF | GO:0030295 | protein kinase activator activity | "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] | 16 | 5.017513e-09 | 0 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 22 | 6.639873e-09 | 0 |
| GO:MF | GO:0001216 | DNA-binding transcription activator activity | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018] | 28 | 7.600830e-09 | 0 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 23 | 8.686595e-09 | 0 |
| GO:MF | GO:0019209 | kinase activator activity | "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] | 16 | 1.226730e-08 | 0 |
| GO:MF | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr] | 7 | 1.415378e-08 | 0 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 45 | 1.627811e-08 | 0 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 22 | 1.895768e-08 | 0 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 135 | 2.341123e-08 | 0 |
| GO:MF | GO:0000976 | transcription cis-regulatory region binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] | 50 | 3.619620e-08 | 0 |
| GO:MF | GO:0001067 | transcription regulatory region nucleic acid binding | "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] | 50 | 3.706515e-08 | 0 |
| GO:MF | GO:0004386 | helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] | 16 | 6.840673e-08 | 0 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 40 | 7.040961e-08 | 0 |
| GO:MF | GO:0030332 | cyclin binding | "Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] | 9 | 1.099872e-07 | 0 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 14 | 1.711476e-07 | 0 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 29 | 5.545666e-07 | 0 |
| GO:MF | GO:0042393 | histone binding | "Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837] | 18 | 6.879208e-07 | 0 |
| GO:MF | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] | 25 | 7.605026e-07 | 0 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 251 | 1.257644e-06 | 0 |
| GO:MF | GO:0003713 | transcription coactivator activity | "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 18 | 1.395656e-06 | 0 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 49 | 3.923848e-06 | 0 |
| GO:MF | GO:0030234 | enzyme regulator activity | "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 43 | 3.944721e-06 | 0 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 22 | 4.799337e-06 | 0 |
| GO:MF | GO:1990841 | promoter-specific chromatin binding | "Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729] | 10 | 5.099049e-06 | 0 |
| GO:MF | GO:0016853 | isomerase activity | "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] | 23 | 5.655676e-06 | 0 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 46 | 6.282748e-06 | 0 |
| GO:MF | GO:0098772 | molecular function regulator activity | "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt] | 58 | 8.736948e-06 | 0 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 46 | 1.436237e-05 | 0 |
| GO:MF | GO:0042826 | histone deacetylase binding | "Binding to histone deacetylase." [GOC:jl] | 12 | 2.857061e-05 | 0 |
| GO:MF | GO:0043425 | bHLH transcription factor binding | "Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] | 7 | 4.863215e-05 | 0 |
| GO:MF | GO:0002039 | p53 binding | "Binding to one of the p53 family of proteins." [GOC:hjd] | 9 | 8.133558e-05 | 0 |
| GO:MF | GO:0003714 | transcription corepressor activity | "A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] | 14 | 9.992021e-05 | 0 |
| GO:MF | GO:0001221 | transcription coregulator binding | "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] | 11 | 1.170343e-04 | 0 |
| GO:MF | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] | 40 | 2.408828e-04 | 0 |
| GO:MF | GO:0030291 | protein serine/threonine kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah] | 7 | 2.952561e-04 | 0 |
| GO:MF | GO:0010484 | histone H3 acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [PMID:19056256] | 5 | 3.445810e-04 | 0 |
| GO:MF | GO:0016922 | nuclear receptor binding | "Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand." [PMID:7776974] | 11 | 5.654970e-04 | 0 |
| GO:MF | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity | "Catalysis of the reaction: a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H+." [PMID:11251121, PMID:16120966, PMID:9614142, RHEA:76255] | 4 | 6.980296e-04 | 0 |
| GO:MF | GO:0001223 | transcription coactivator binding | "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] | 7 | 7.750753e-04 | 0 |
| GO:MF | GO:0043993 | histone H3K18 acetyltransferase activity | "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)." [PMID:18552846] | 3 | 8.432425e-04 | 0 |
| GO:MF | GO:0008047 | enzyme activator activity | "Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 23 | 1.133175e-03 | 0 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 55 | 2.281251e-03 | 0 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 55 | 2.847782e-03 | 0 |
| GO:MF | GO:0140993 | histone modifying activity | "A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression." [GOC:pg] | 12 | 2.968234e-03 | 0 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 36 | 3.042989e-03 | 0 |
| GO:MF | GO:0000987 | cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018] | 34 | 3.089635e-03 | 0 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 57 | 3.195419e-03 | 0 |
| GO:MF | GO:0017116 | single-stranded DNA helicase activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl] | 5 | 3.558928e-03 | 0 |
| GO:MF | GO:0140030 | modification-dependent protein binding | "Binding to a protein upon post-translation modification of the target protein." [PMID:26060076] | 11 | 4.277653e-03 | 0 |
| GO:MF | GO:0035035 | histone acetyltransferase binding | "Binding to an histone acetyltransferase." [GOC:bf] | 5 | 4.449985e-03 | 0 |
| GO:MF | GO:0004520 | DNA endonuclease activity | "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] | 6 | 4.838521e-03 | 0 |
| GO:MF | GO:0035173 | histone kinase activity | "Catalysis of the transfer of a phosphate group to a histone." [GOC:bf] | 5 | 5.506192e-03 | 0 |
| GO:MF | GO:0001046 | core promoter sequence-specific DNA binding | "Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH] | 6 | 5.586512e-03 | 0 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 50 | 6.391871e-03 | 0 |
| GO:MF | GO:0004536 | DNA nuclease activity | "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] | 7 | 7.850315e-03 | 0 |
| GO:MF | GO:0019789 | SUMO transferase activity | "Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250] | 5 | 9.879436e-03 | 0 |
| GO:MF | GO:0140677 | molecular function activator activity | "A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators] | 32 | 1.208356e-02 | 0 |
| GO:MF | GO:0046983 | protein dimerization activity | "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] | 31 | 1.285840e-02 | 0 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 50 | 1.300990e-02 | 0 |
| GO:MF | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018] | 32 | 1.333829e-02 | 0 |
| GO:MF | GO:0004860 | protein kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a protein kinase." [GOC:ai] | 7 | 1.819410e-02 | 0 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 47 | 1.886726e-02 | 0 |
| GO:MF | GO:0106310 | protein serine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989] | 15 | 2.167194e-02 | 0 |
| GO:MF | GO:0019210 | kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a kinase." [GOC:mah] | 7 | 2.762409e-02 | 0 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 47 | 3.774735e-02 | 0 |
| GO:MF | GO:0048256 | flap endonuclease activity | "Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid] | 3 | 4.508565e-02 | 0 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 47 | 4.561530e-02 | 0 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 114 | 1.157496e-13 | 0 |
| HPA | HPA:0570781 | Testis; preleptotene spermatocytes[≥Low] | Testis; preleptotene spermatocytes[≥Low] | 80 | 2.275433e-12 | 0 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 124 | 7.464430e-11 | 0 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 140 | 2.653897e-10 | 0 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 163 | 3.143452e-10 | 0 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 163 | 3.143452e-10 | 0 |
| HPA | HPA:0620000 | Vagina | Vagina | 155 | 4.946636e-10 | 0 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 155 | 4.946636e-10 | 0 |
| HPA | HPA:0570782 | Testis; preleptotene spermatocytes[≥Medium] | Testis; preleptotene spermatocytes[≥Medium] | 65 | 5.388924e-10 | 0 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 158 | 1.488634e-09 | 0 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 158 | 1.488634e-09 | 0 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 164 | 2.216265e-09 | 0 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 164 | 2.216265e-09 | 0 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 125 | 3.649113e-09 | 0 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 46 | 4.457500e-09 | 0 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 62 | 6.266051e-09 | 0 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 152 | 1.075307e-08 | 0 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 153 | 1.279558e-08 | 0 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 51 | 2.469388e-08 | 0 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 121 | 2.969080e-08 | 0 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 153 | 3.491848e-08 | 0 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 44 | 1.048228e-07 | 0 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 158 | 1.341757e-07 | 0 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 45 | 2.212071e-07 | 0 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 37 | 3.161122e-07 | 0 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 45 | 4.187223e-07 | 0 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 175 | 5.081471e-07 | 0 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 52 | 5.790159e-07 | 0 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 94 | 6.812233e-07 | 0 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 42 | 9.566974e-07 | 0 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 38 | 1.705110e-06 | 0 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 163 | 1.898718e-06 | 0 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 39 | 2.256760e-06 | 0 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 50 | 2.659544e-06 | 0 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 36 | 3.567388e-06 | 0 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 44 | 8.058393e-06 | 0 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 110 | 1.271434e-05 | 0 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 165 | 1.290042e-05 | 0 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 165 | 1.290042e-05 | 0 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 101 | 1.315825e-05 | 0 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 164 | 1.469302e-05 | 0 |
| HPA | HPA:0380000 | Placenta | Placenta | 168 | 1.480459e-05 | 0 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 135 | 1.807202e-05 | 0 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 21 | 2.210456e-05 | 0 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 32 | 3.023027e-05 | 0 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 154 | 3.295406e-05 | 0 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 30 | 3.377821e-05 | 0 |
| HPA | HPA:0630000 | Cervix | Cervix | 158 | 4.259166e-05 | 0 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 35 | 4.892347e-05 | 0 |
| HPA | HPA:0570000 | Testis | Testis | 187 | 4.921260e-05 | 0 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 30 | 6.370876e-05 | 0 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 45 | 7.221429e-05 | 0 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 40 | 7.374870e-05 | 0 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 78 | 7.612561e-05 | 0 |
| HPA | HPA:0570762 | Testis; pachytene spermatocytes[≥Medium] | Testis; pachytene spermatocytes[≥Medium] | 63 | 9.466619e-05 | 0 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 110 | 1.185994e-04 | 0 |
| HPA | HPA:0570761 | Testis; pachytene spermatocytes[≥Low] | Testis; pachytene spermatocytes[≥Low] | 73 | 1.239626e-04 | 0 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 86 | 1.395770e-04 | 0 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 35 | 1.406267e-04 | 0 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 46 | 1.563398e-04 | 0 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 28 | 1.779318e-04 | 0 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 125 | 1.848376e-04 | 0 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 52 | 2.244049e-04 | 0 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 105 | 2.378309e-04 | 0 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 44 | 2.661068e-04 | 0 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 26 | 3.543647e-04 | 0 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 122 | 3.773504e-04 | 0 |
| HPA | HPA:0060851 | Bronchus; ciliated cells (cell body)[≥Low] | Bronchus; ciliated cells (cell body)[≥Low] | 44 | 4.550910e-04 | 0 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 37 | 6.638366e-04 | 0 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 36 | 7.353037e-04 | 0 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 36 | 7.950682e-04 | 0 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 22 | 7.995868e-04 | 0 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 64 | 8.443537e-04 | 0 |
| HPA | HPA:0570783 | Testis; preleptotene spermatocytes[High] | Testis; preleptotene spermatocytes[High] | 32 | 1.133125e-03 | 0 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 31 | 1.148482e-03 | 0 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 29 | 1.245793e-03 | 0 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 31 | 1.287639e-03 | 0 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 17 | 1.369386e-03 | 0 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 62 | 1.387609e-03 | 0 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 31 | 1.442193e-03 | 0 |
| HPA | HPA:0060841 | Bronchus; basal cells[≥Low] | Bronchus; basal cells[≥Low] | 28 | 1.466090e-03 | 0 |
| HPA | HPA:0060843 | Bronchus; basal cells[High] | Bronchus; basal cells[High] | 13 | 1.466352e-03 | 0 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 54 | 1.467879e-03 | 0 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 127 | 1.537000e-03 | 0 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 44 | 1.593710e-03 | 0 |
| HPA | HPA:0381193 | Placenta; cytotrophoblasts[High] | Placenta; cytotrophoblasts[High] | 18 | 1.689705e-03 | 0 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 21 | 1.748235e-03 | 0 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 16 | 1.863671e-03 | 0 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 97 | 1.925665e-03 | 0 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 29 | 1.945920e-03 | 0 |
| HPA | HPA:0380523 | Placenta; trophoblastic cells[High] | Placenta; trophoblastic cells[High] | 60 | 1.947395e-03 | 0 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 16 | 2.071088e-03 | 0 |
| HPA | HPA:0210851 | Fallopian tube; ciliated cells (cell body)[≥Low] | Fallopian tube; ciliated cells (cell body)[≥Low] | 37 | 2.269914e-03 | 0 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 21 | 2.304043e-03 | 0 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 161 | 2.360055e-03 | 0 |
| HPA | HPA:0320851 | Nasopharynx; ciliated cells (cell body)[≥Low] | Nasopharynx; ciliated cells (cell body)[≥Low] | 41 | 2.566178e-03 | 0 |
| HPA | HPA:0320852 | Nasopharynx; ciliated cells (cell body)[≥Medium] | Nasopharynx; ciliated cells (cell body)[≥Medium] | 35 | 2.607829e-03 | 0 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 31 | 2.643110e-03 | 0 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 19 | 2.649620e-03 | 0 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 128 | 2.825936e-03 | 0 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 128 | 2.825936e-03 | 0 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 103 | 3.008778e-03 | 0 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 117 | 3.132680e-03 | 0 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 33 | 3.574497e-03 | 0 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 26 | 3.836835e-03 | 0 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 50 | 3.957233e-03 | 0 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 32 | 3.957780e-03 | 0 |
| HPA | HPA:0401331 | Rectum; mucosal lymphoid cells[≥Low] | Rectum; mucosal lymphoid cells[≥Low] | 25 | 4.086677e-03 | 0 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 167 | 4.098699e-03 | 0 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 38 | 4.224683e-03 | 0 |
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 20 | 4.258490e-03 | 0 |
| HPA | HPA:0401301 | Rectum; enterocytes[≥Low] | Rectum; enterocytes[≥Low] | 24 | 4.585339e-03 | 0 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 67 | 4.950429e-03 | 0 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 167 | 5.314631e-03 | 0 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 29 | 5.472563e-03 | 0 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 17 | 5.948385e-03 | 0 |
| HPA | HPA:0030071 | Appendix; lymphoid tissue[≥Low] | Appendix; lymphoid tissue[≥Low] | 114 | 6.144848e-03 | 0 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 156 | 6.319957e-03 | 0 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 22 | 6.404211e-03 | 0 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 100 | 6.553237e-03 | 0 |
| HPA | HPA:0401293 | Rectum; endocrine cells[High] | Rectum; endocrine cells[High] | 16 | 7.393280e-03 | 0 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 76 | 7.487410e-03 | 0 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 29 | 7.509519e-03 | 0 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 149 | 7.521502e-03 | 0 |
| HPA | HPA:0130000 | Colon | Colon | 173 | 7.667486e-03 | 0 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 119 | 9.204430e-03 | 0 |
| HPA | HPA:0300000 | Lung | Lung | 158 | 1.036877e-02 | 0 |
| HPA | HPA:0211091 | Fallopian tube; non-ciliated cells[≥Low] | Fallopian tube; non-ciliated cells[≥Low] | 30 | 1.048371e-02 | 0 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 149 | 1.054152e-02 | 0 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 90 | 1.180899e-02 | 0 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 20 | 1.226096e-02 | 0 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 98 | 1.298752e-02 | 0 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 98 | 1.298752e-02 | 0 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 44 | 1.534746e-02 | 0 |
| HPA | HPA:0500702 | Soft tissue 1; peripheral nerve[≥Medium] | Soft tissue 1; peripheral nerve[≥Medium] | 44 | 1.562199e-02 | 0 |
| HPA | HPA:0030432 | Appendix; germinal center cells[≥Medium] | Appendix; germinal center cells[≥Medium] | 14 | 1.600009e-02 | 0 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 134 | 1.642622e-02 | 0 |
| HPA | HPA:0530000 | Spleen | Spleen | 133 | 1.678276e-02 | 0 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 35 | 1.912002e-02 | 0 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 107 | 1.919737e-02 | 0 |
| HPA | HPA:0050000 | Breast | Breast | 154 | 2.053006e-02 | 0 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 129 | 2.119898e-02 | 0 |
| HPA | HPA:0381192 | Placenta; cytotrophoblasts[≥Medium] | Placenta; cytotrophoblasts[≥Medium] | 20 | 2.166280e-02 | 0 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 109 | 2.226567e-02 | 0 |
| HPA | HPA:0320893 | Nasopharynx; goblet cells[High] | Nasopharynx; goblet cells[High] | 11 | 2.273605e-02 | 0 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 73 | 2.353567e-02 | 0 |
| HPA | HPA:0481301 | Small intestine; enterocytes[≥Low] | Small intestine; enterocytes[≥Low] | 24 | 2.542706e-02 | 0 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 46 | 2.610442e-02 | 0 |
| HPA | HPA:0060852 | Bronchus; ciliated cells (cell body)[≥Medium] | Bronchus; ciliated cells (cell body)[≥Medium] | 32 | 2.611171e-02 | 0 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 31 | 2.655551e-02 | 0 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 21 | 2.732333e-02 | 0 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 74 | 3.048137e-02 | 0 |
| HPA | HPA:0131331 | Colon; mucosal lymphoid cells[≥Low] | Colon; mucosal lymphoid cells[≥Low] | 22 | 3.501259e-02 | 0 |
| HPA | HPA:0380203 | Placenta; endothelial cells[High] | Placenta; endothelial cells[High] | 14 | 3.634105e-02 | 0 |
| HPA | HPA:0381191 | Placenta; cytotrophoblasts[≥Low] | Placenta; cytotrophoblasts[≥Low] | 21 | 3.679535e-02 | 0 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 98 | 3.736495e-02 | 0 |
| HPA | HPA:0211092 | Fallopian tube; non-ciliated cells[≥Medium] | Fallopian tube; non-ciliated cells[≥Medium] | 24 | 4.420647e-02 | 0 |
| HPA | HPA:0381203 | Placenta; hofbauer cells[High] | Placenta; hofbauer cells[High] | 15 | 4.844835e-02 | 0 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 71 | 4.861741e-02 | 0 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 45 | 2.957900e-12 | 0 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 52 | 8.949285e-09 | 0 |
| MIRNA | MIRNA:hsa-mir-34a-5p | hsa-mir-34a-5p | hsa-mir-34a-5p | 30 | 5.557519e-07 | 0 |
| MIRNA | MIRNA:hsa-mir-192-5p | hsa-mir-192-5p | hsa-mir-192-5p | 37 | 1.639485e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-125b-5p | hsa-mir-125b-5p | hsa-mir-125b-5p | 23 | 3.729415e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-215-5p | hsa-mir-215-5p | hsa-mir-215-5p | 31 | 3.817327e-05 | 0 |
| MIRNA | MIRNA:hsa-let-7b-5p | hsa-let-7b-5p | hsa-let-7b-5p | 41 | 5.756750e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-221-3p | hsa-mir-221-3p | hsa-mir-221-3p | 21 | 6.843300e-05 | 0 |
| MIRNA | MIRNA:hsa-mir-20a-5p | hsa-mir-20a-5p | hsa-mir-20a-5p | 37 | 1.957838e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-145-3p | hsa-mir-145-3p | hsa-mir-145-3p | 9 | 2.126984e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-223-3p | hsa-mir-223-3p | hsa-mir-223-3p | 11 | 6.100923e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-24-3p | hsa-mir-24-3p | hsa-mir-24-3p | 30 | 9.456769e-04 | 0 |
| MIRNA | MIRNA:hsa-mir-205-5p | hsa-mir-205-5p | hsa-mir-205-5p | 13 | 1.629225e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-17-5p | hsa-mir-17-5p | hsa-mir-17-5p | 37 | 2.020485e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-222-3p | hsa-mir-222-3p | hsa-mir-222-3p | 19 | 2.336215e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-503-5p | hsa-mir-503-5p | hsa-mir-503-5p | 15 | 2.409500e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-449b-5p | hsa-mir-449b-5p | hsa-mir-449b-5p | 10 | 2.619114e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-1301-3p | hsa-mir-1301-3p | hsa-mir-1301-3p | 13 | 3.408816e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-26a-5p | hsa-mir-26a-5p | hsa-mir-26a-5p | 20 | 4.175508e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-29a-3p | hsa-mir-29a-3p | hsa-mir-29a-3p | 14 | 6.427750e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-133a-3p | hsa-mir-133a-3p | hsa-mir-133a-3p | 10 | 7.589890e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-429 | hsa-mir-429 | hsa-mir-429 | 42 | 8.464129e-03 | 0 |
| MIRNA | MIRNA:hsa-mir-30c-5p | hsa-mir-30c-5p | hsa-mir-30c-5p | 21 | 1.004278e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-200b | hsa-mir-200b | hsa-mir-200b | 41 | 1.032116e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-200c | hsa-mir-200c | hsa-mir-200c | 41 | 1.032116e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-100-5p | hsa-mir-100-5p | hsa-mir-100-5p | 14 | 1.046312e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-138-5p | hsa-mir-138-5p | hsa-mir-138-5p | 9 | 2.283592e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-32-5p | hsa-mir-32-5p | hsa-mir-32-5p | 20 | 2.527934e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-6871-5p | hsa-mir-6871-5p | hsa-mir-6871-5p | 8 | 2.594788e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4268 | hsa-mir-4268 | hsa-mir-4268 | 29 | 2.709716e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 30 | 2.935883e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-4789-5p | hsa-mir-4789-5p | hsa-mir-4789-5p | 41 | 3.194591e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-548o | hsa-mir-548o | hsa-mir-548o | 40 | 3.902479e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-15a-5p | hsa-mir-15a-5p | hsa-mir-15a-5p | 24 | 4.202832e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-330-3p | hsa-mir-330-3p | hsa-mir-330-3p | 42 | 4.329584e-02 | 0 |
| MIRNA | MIRNA:hsa-mir-548aa | hsa-mir-548aa | hsa-mir-548aa | 45 | 4.401332e-02 | 0 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11531_1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | 216 | 1.177562e-11 | 0 |
| TF | TF:M07250_1 | Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 | Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 | 130 | 2.125906e-11 | 0 |
| TF | TF:M00939_1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | 61 | 2.483377e-10 | 0 |
| TF | TF:M00431_1 | Factor: E2F-1; motif: TTTSGCGS; match class: 1 | Factor: E2F-1; motif: TTTSGCGS; match class: 1 | 72 | 5.292153e-10 | 0 |
| TF | TF:M11531 | Factor: E2F-2; motif: GCGCGCGCGYW | Factor: E2F-2; motif: GCGCGCGCGYW | 222 | 6.494111e-10 | 0 |
| TF | TF:M00919_1 | Factor: E2F; motif: NCSCGCSAAAN; match class: 1 | Factor: E2F; motif: NCSCGCSAAAN; match class: 1 | 57 | 7.193372e-10 | 0 |
| TF | TF:M04869 | Factor: Egr-1; motif: GCGCATGCG | Factor: Egr-1; motif: GCGCATGCG | 200 | 1.266296e-09 | 0 |
| TF | TF:M00716_1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | 229 | 1.982410e-09 | 0 |
| TF | TF:M00516 | Factor: E2F-1; motif: TTTSGCGCGMNR | Factor: E2F-1; motif: TTTSGCGCGMNR | 145 | 2.551267e-09 | 0 |
| TF | TF:M00940 | Factor: E2F-1; motif: NTTTCGCGCS | Factor: E2F-1; motif: NTTTCGCGCS | 157 | 2.990985e-09 | 0 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 111 | 4.655056e-09 | 0 |
| TF | TF:M00920 | Factor: E2F; motif: NKCGCGCSAAAN | Factor: E2F; motif: NKCGCGCSAAAN | 126 | 9.208047e-09 | 0 |
| TF | TF:M04869_1 | Factor: Egr-1; motif: GCGCATGCG; match class: 1 | Factor: Egr-1; motif: GCGCATGCG; match class: 1 | 186 | 1.713477e-08 | 0 |
| TF | TF:M00427 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 177 | 1.903038e-08 | 0 |
| TF | TF:M00333_1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | 210 | 2.810735e-08 | 0 |
| TF | TF:M00918 | Factor: E2F; motif: TTTSGCGSG | Factor: E2F; motif: TTTSGCGSG | 123 | 4.065567e-08 | 0 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 225 | 4.543995e-08 | 0 |
| TF | TF:M07250 | Factor: E2F-1; motif: NNNSSCGCSAANN | Factor: E2F-1; motif: NNNSSCGCSAANN | 190 | 7.452217e-08 | 0 |
| TF | TF:M00431 | Factor: E2F-1; motif: TTTSGCGS | Factor: E2F-1; motif: TTTSGCGS | 146 | 8.573434e-08 | 0 |
| TF | TF:M00333 | Factor: ZF5; motif: NRNGNGCGCGCWN | Factor: ZF5; motif: NRNGNGCGCGCWN | 234 | 1.821176e-07 | 0 |
| TF | TF:M00738 | Factor: E2F-4:DP-1; motif: TTTSGCGC | Factor: E2F-4:DP-1; motif: TTTSGCGC | 178 | 1.894699e-07 | 0 |
| TF | TF:M00986_1 | Factor: Churchill; motif: CGGGNN; match class: 1 | Factor: Churchill; motif: CGGGNN; match class: 1 | 185 | 2.136864e-07 | 0 |
| TF | TF:M00426 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 202 | 2.341509e-07 | 0 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 232 | 2.576834e-07 | 0 |
| TF | TF:M00919 | Factor: E2F; motif: NCSCGCSAAAN | Factor: E2F; motif: NCSCGCSAAAN | 129 | 2.961358e-07 | 0 |
| TF | TF:M07039_1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | 220 | 3.087386e-07 | 0 |
| TF | TF:M08875 | Factor: E2F; motif: NNTTTCGCGCN | Factor: E2F; motif: NNTTTCGCGCN | 129 | 5.909939e-07 | 0 |
| TF | TF:M00736 | Factor: E2F-1:DP-1; motif: TTTCSCGC | Factor: E2F-1:DP-1; motif: TTTCSCGC | 183 | 7.062581e-07 | 0 |
| TF | TF:M00426_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 123 | 7.368728e-07 | 0 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 238 | 7.691720e-07 | 0 |
| TF | TF:M00427_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 92 | 1.029668e-06 | 0 |
| TF | TF:M00918_1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | Factor: E2F; motif: TTTSGCGSG; match class: 1 | 45 | 1.182025e-06 | 0 |
| TF | TF:M00428 | Factor: E2F-1; motif: NKTSSCGC | Factor: E2F-1; motif: NKTSSCGC | 165 | 1.260852e-06 | 0 |
| TF | TF:M02089 | Factor: E2F-3; motif: GGCGGGN | Factor: E2F-3; motif: GGCGGGN | 214 | 1.545292e-06 | 0 |
| TF | TF:M02090 | Factor: E2F-4; motif: GCGGGAAANA | Factor: E2F-4; motif: GCGGGAAANA | 200 | 2.831511e-06 | 0 |
| TF | TF:M08875_1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | 54 | 3.129223e-06 | 0 |
| TF | TF:M00739_1 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 | 43 | 3.201769e-06 | 0 |
| TF | TF:M00425_1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | 114 | 3.783103e-06 | 0 |
| TF | TF:M08205_1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | 182 | 3.940561e-06 | 0 |
| TF | TF:M07206_1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | 187 | 4.611068e-06 | 0 |
| TF | TF:M08874 | Factor: E2F1; motif: NNNNNGCGSSAAAN | Factor: E2F1; motif: NNNNNGCGSSAAAN | 140 | 5.203641e-06 | 0 |
| TF | TF:M10438 | Factor: ZF5; motif: GGSGCGCGS | Factor: ZF5; motif: GGSGCGCGS | 241 | 5.238831e-06 | 0 |
| TF | TF:M00740 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC | 181 | 7.693498e-06 | 0 |
| TF | TF:M13366 | Factor: ZBED4; motif: CCCGCYCCGC | Factor: ZBED4; motif: CCCGCYCCGC | 146 | 8.079822e-06 | 0 |
| TF | TF:M07380 | Factor: E2F-4; motif: NTTTCSCGCC | Factor: E2F-4; motif: NTTTCSCGCC | 210 | 1.011427e-05 | 0 |
| TF | TF:M07206 | Factor: E2F-1; motif: NGGGCGGGARV | Factor: E2F-1; motif: NGGGCGGGARV | 226 | 1.047505e-05 | 0 |
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 212 | 1.053376e-05 | 0 |
| TF | TF:M11018_1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | 238 | 1.099934e-05 | 0 |
| TF | TF:M09896 | Factor: E2F-7; motif: GRGGCGGGAANNN | Factor: E2F-7; motif: GRGGCGGGAANNN | 175 | 1.160403e-05 | 0 |
| TF | TF:M00938 | Factor: E2F-1; motif: TTGGCGCGRAANNGNM | Factor: E2F-1; motif: TTGGCGCGRAANNGNM | 140 | 1.373651e-05 | 0 |
| TF | TF:M00940_1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | 69 | 1.382032e-05 | 0 |
| TF | TF:M00939 | Factor: E2F; motif: TTTSGCGSG | Factor: E2F; motif: TTTSGCGSG | 128 | 1.529406e-05 | 0 |
| TF | TF:M08525_1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | 232 | 1.722991e-05 | 0 |
| TF | TF:M00050_1 | Factor: E2F; motif: TTTSGCGC; match class: 1 | Factor: E2F; motif: TTTSGCGC; match class: 1 | 55 | 1.863062e-05 | 0 |
| TF | TF:M01240 | Factor: BEN; motif: CAGCGRNV | Factor: BEN; motif: CAGCGRNV | 242 | 2.210187e-05 | 0 |
| TF | TF:M00738_1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | 91 | 2.359263e-05 | 0 |
| TF | TF:M12227 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN | Factor: ZIC4; motif: NNCCNCCCRYNGYGN | 187 | 2.752859e-05 | 0 |
| TF | TF:M00740_1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | 100 | 2.864375e-05 | 0 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 229 | 2.952459e-05 | 0 |
| TF | TF:M08207_1 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 | 233 | 3.665396e-05 | 0 |
| TF | TF:M00920_1 | Factor: E2F; motif: NKCGCGCSAAAN; match class: 1 | Factor: E2F; motif: NKCGCGCSAAAN; match class: 1 | 43 | 3.756186e-05 | 0 |
| TF | TF:M12598_1 | Factor: E2F3; motif: NNRGMKGGAR; match class: 1 | Factor: E2F3; motif: NNRGMKGGAR; match class: 1 | 134 | 3.915398e-05 | 0 |
| TF | TF:M00050 | Factor: E2F; motif: TTTSGCGC | Factor: E2F; motif: TTTSGCGC | 135 | 4.125268e-05 | 0 |
| TF | TF:M11529 | Factor: E2F-2; motif: GCGCGCGCNCS | Factor: E2F-2; motif: GCGCGCGCNCS | 240 | 4.292141e-05 | 0 |
| TF | TF:M02089_1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | 166 | 4.799187e-05 | 0 |
| TF | TF:M10072 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | 180 | 4.882463e-05 | 0 |
| TF | TF:M09892 | Factor: E2F-1; motif: NNNNGGCGGGAARN | Factor: E2F-1; motif: NNNNGGCGGGAARN | 214 | 5.050261e-05 | 0 |
| TF | TF:M10072_1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 | 124 | 5.257462e-05 | 0 |
| TF | TF:M08525 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM | 246 | 5.700022e-05 | 0 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 238 | 7.026744e-05 | 0 |
| TF | TF:M00516_1 | Factor: E2F-1; motif: TTTSGCGCGMNR; match class: 1 | Factor: E2F-1; motif: TTTSGCGCGMNR; match class: 1 | 57 | 7.325109e-05 | 0 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 178 | 8.518681e-05 | 0 |
| TF | TF:M03924 | Factor: YY1; motif: NNCGCCATTNN | Factor: YY1; motif: NNCGCCATTNN | 173 | 8.884550e-05 | 0 |
| TF | TF:M04691_1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | 178 | 1.015480e-04 | 0 |
| TF | TF:M08266_1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | 159 | 1.143458e-04 | 0 |
| TF | TF:M03862_1 | Factor: YB-1; motif: NNNNCCAATNN; match class: 1 | Factor: YB-1; motif: NNNNCCAATNN; match class: 1 | 74 | 1.143610e-04 | 0 |
| TF | TF:M12351_1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | 148 | 1.197404e-04 | 0 |
| TF | TF:M12597 | Factor: E2F1; motif: GSGCGGGAAN | Factor: E2F1; motif: GSGCGGGAAN | 218 | 1.238149e-04 | 0 |
| TF | TF:M00425 | Factor: E2F; motif: TTTCGCGC | Factor: E2F; motif: TTTCGCGC | 185 | 1.441339e-04 | 0 |
| TF | TF:M08205 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | 222 | 1.543089e-04 | 0 |
| TF | TF:M01593 | Factor: Zfx; motif: SNSCAGGCCKCGSCSS | Factor: Zfx; motif: SNSCAGGCCKCGSCSS | 91 | 1.739168e-04 | 0 |
| TF | TF:M07380_1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | 146 | 1.800994e-04 | 0 |
| TF | TF:M12597_1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | 170 | 2.216106e-04 | 0 |
| TF | TF:M08266 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG | 220 | 2.311409e-04 | 0 |
| TF | TF:M07084_1 | Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 | Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 | 110 | 2.380762e-04 | 0 |
| TF | TF:M09893_1 | Factor: E2F-3; motif: NNGGCGGGAAA; match class: 1 | Factor: E2F-3; motif: NNGGCGGGAAA; match class: 1 | 42 | 2.629168e-04 | 0 |
| TF | TF:M11603_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 208 | 2.825905e-04 | 0 |
| TF | TF:M12722 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS | 178 | 2.880951e-04 | 0 |
| TF | TF:M04823 | Factor: E2F-4; motif: NNTTCCCGCCNN | Factor: E2F-4; motif: NNTTCCCGCCNN | 203 | 4.082923e-04 | 0 |
| TF | TF:M07084 | Factor: E2F-4; motif: NGGCGGGAARN | Factor: E2F-4; motif: NGGCGGGAARN | 181 | 4.100992e-04 | 0 |
| TF | TF:M11528_1 | Factor: E2F-2; motif: NTTTTGGCGCCAWWWN; match class: 1 | Factor: E2F-2; motif: NTTTTGGCGCCAWWWN; match class: 1 | 99 | 4.192813e-04 | 0 |
| TF | TF:M00739 | Factor: E2F-4:DP-2; motif: TTTCSCGC | Factor: E2F-4:DP-2; motif: TTTCSCGC | 111 | 4.922045e-04 | 0 |
| TF | TF:M00737_1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | 70 | 4.963464e-04 | 0 |
| TF | TF:M09892_1 | Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 | Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 | 160 | 5.146186e-04 | 0 |
| TF | TF:M04515 | Factor: E2F-1; motif: WWTGGCGCCAAA | Factor: E2F-1; motif: WWTGGCGCCAAA | 209 | 5.390254e-04 | 0 |
| TF | TF:M11530 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | 222 | 5.531588e-04 | 0 |
| TF | TF:M09636_1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | 217 | 6.538841e-04 | 0 |
| TF | TF:M03922 | Factor: SP4; motif: NWRGCCACGCCCMCTYN | Factor: SP4; motif: NWRGCCACGCCCMCTYN | 117 | 6.882919e-04 | 0 |
| TF | TF:M11529_1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | 221 | 6.898716e-04 | 0 |
| TF | TF:M04823_1 | Factor: E2F-4; motif: NNTTCCCGCCNN; match class: 1 | Factor: E2F-4; motif: NNTTCCCGCCNN; match class: 1 | 142 | 7.609489e-04 | 0 |
| TF | TF:M11533_1 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN; match class: 1 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN; match class: 1 | 153 | 7.652231e-04 | 0 |
| TF | TF:M09894 | Factor: E2F-4; motif: SNGGGCGGGAANN | Factor: E2F-4; motif: SNGGGCGGGAANN | 237 | 7.914298e-04 | 0 |
| TF | TF:M01857 | Factor: AP-2alpha; motif: NGCCYSNNGSN | Factor: AP-2alpha; motif: NGCCYSNNGSN | 159 | 8.323784e-04 | 0 |
| TF | TF:M00430_1 | Factor: E2F-1; motif: NTTSGCGG; match class: 1 | Factor: E2F-1; motif: NTTSGCGG; match class: 1 | 62 | 8.417317e-04 | 0 |
| TF | TF:M11535 | Factor: E2F-4; motif: TTTTGGCGCCAWWN | Factor: E2F-4; motif: TTTTGGCGCCAWWN | 180 | 8.795180e-04 | 0 |
| TF | TF:M02106 | Factor: NF-YA; motif: CRGCCAATCAGNRN | Factor: NF-YA; motif: CRGCCAATCAGNRN | 48 | 9.714399e-04 | 0 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 242 | 9.938275e-04 | 0 |
| TF | TF:M00931 | Factor: Sp1; motif: GGGGCGGGGC | Factor: Sp1; motif: GGGGCGGGGC | 173 | 1.011865e-03 | 0 |
| TF | TF:M12173_1 | Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 | Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 | 101 | 1.047845e-03 | 0 |
| TF | TF:M11430 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 179 | 1.078109e-03 | 0 |
| TF | TF:M12642 | Factor: NFYA; motif: NNRGCCAATSRGMRSSNNSN | Factor: NFYA; motif: NNRGCCAATSRGMRSSNNSN | 66 | 1.242553e-03 | 0 |
| TF | TF:M00695_1 | Factor: ETF; motif: GVGGMGG; match class: 1 | Factor: ETF; motif: GVGGMGG; match class: 1 | 130 | 1.255492e-03 | 0 |
| TF | TF:M02065 | Factor: ER81; motif: RCCGGAARYN | Factor: ER81; motif: RCCGGAARYN | 201 | 1.386829e-03 | 0 |
| TF | TF:M00196 | Factor: Sp1; motif: NGGGGGCGGGGYN | Factor: Sp1; motif: NGGGGGCGGGGYN | 172 | 1.436905e-03 | 0 |
| TF | TF:M11533 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN | 205 | 1.603145e-03 | 0 |
| TF | TF:M00932 | Factor: Sp1; motif: NNGGGGCGGGGNN | Factor: Sp1; motif: NNGGGGCGGGGNN | 174 | 1.632958e-03 | 0 |
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 227 | 1.796269e-03 | 0 |
| TF | TF:M00008_1 | Factor: Sp1; motif: GGGGCGGGGT; match class: 1 | Factor: Sp1; motif: GGGGCGGGGT; match class: 1 | 100 | 1.989051e-03 | 0 |
| TF | TF:M12642_1 | Factor: NFYA; motif: NNRGCCAATSRGMRSSNNSN; match class: 1 | Factor: NFYA; motif: NNRGCCAATSRGMRSSNNSN; match class: 1 | 23 | 2.148856e-03 | 0 |
| TF | TF:M08020 | Factor: YY2; motif: NNCCGCCATTW | Factor: YY2; motif: NNCCGCCATTW | 44 | 2.297695e-03 | 0 |
| TF | TF:M12616_1 | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS; match class: 1 | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS; match class: 1 | 23 | 2.429847e-03 | 0 |
| TF | TF:M12554 | Factor: YY2; motif: NNATGGCGGCN | Factor: YY2; motif: NNATGGCGGCN | 63 | 2.437123e-03 | 0 |
| TF | TF:M00430 | Factor: E2F-1; motif: NTTSGCGG | Factor: E2F-1; motif: NTTSGCGG | 142 | 2.761020e-03 | 0 |
| TF | TF:M09723 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS | 168 | 2.832140e-03 | 0 |
| TF | TF:M12599 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN | 244 | 2.862662e-03 | 0 |
| TF | TF:M00986 | Factor: Churchill; motif: CGGGNN | Factor: Churchill; motif: CGGGNN | 216 | 3.028494e-03 | 0 |
| TF | TF:M11018 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | 242 | 3.068208e-03 | 0 |
| TF | TF:M00008 | Factor: Sp1; motif: GGGGCGGGGT | Factor: Sp1; motif: GGGGCGGGGT | 168 | 3.808973e-03 | 0 |
| TF | TF:M00189_1 | Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 | Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 | 115 | 3.867169e-03 | 0 |
| TF | TF:M04516 | Factor: E2F-1; motif: TTTGGCGCCAAA | Factor: E2F-1; motif: TTTGGCGCCAAA | 184 | 3.993854e-03 | 0 |
| TF | TF:M12351 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC | 194 | 4.187858e-03 | 0 |
| TF | TF:M02071 | Factor: ETV7; motif: NCCGGAANNN | Factor: ETV7; motif: NCCGGAANNN | 168 | 4.211990e-03 | 0 |
| TF | TF:M01783 | Factor: SP2; motif: GGGCGGGAC | Factor: SP2; motif: GGGCGGGAC | 156 | 4.226070e-03 | 0 |
| TF | TF:M03977_1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | 94 | 4.315801e-03 | 0 |
| TF | TF:M04106_1 | Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 | Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 | 146 | 4.862463e-03 | 0 |
| TF | TF:M11022 | Factor: IRX2a; motif: ACRYGNNNNACRYGT | Factor: IRX2a; motif: ACRYGNNNNACRYGT | 160 | 4.896777e-03 | 0 |
| TF | TF:M08874_1 | Factor: E2F1; motif: NNNNNGCGSSAAAN; match class: 1 | Factor: E2F1; motif: NNNNNGCGSSAAAN; match class: 1 | 54 | 5.101071e-03 | 0 |
| TF | TF:M02065_1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | 127 | 5.161599e-03 | 0 |
| TF | TF:M08313_1 | Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 | Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 | 162 | 5.529288e-03 | 0 |
| TF | TF:M11530_1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | 207 | 5.668611e-03 | 0 |
| TF | TF:M12616 | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS | Factor: HMGXB3; motif: NRGCCAATSRGNRNNS | 65 | 5.919343e-03 | 0 |
| TF | TF:M01783_1 | Factor: SP2; motif: GGGCGGGAC; match class: 1 | Factor: SP2; motif: GGGCGGGAC; match class: 1 | 89 | 6.082761e-03 | 0 |
| TF | TF:M09896_1 | Factor: E2F-7; motif: GRGGCGGGAANNN; match class: 1 | Factor: E2F-7; motif: GRGGCGGGAANNN; match class: 1 | 92 | 6.248032e-03 | 0 |
| TF | TF:M02070 | Factor: TEL1; motif: CNCGGAANNN | Factor: TEL1; motif: CNCGGAANNN | 176 | 6.721391e-03 | 0 |
| TF | TF:M00931_1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | Factor: Sp1; motif: GGGGCGGGGC; match class: 1 | 112 | 7.316329e-03 | 0 |
| TF | TF:M00245_1 | Factor: Egr-3; motif: NTGCGTGGGCGK; match class: 1 | Factor: Egr-3; motif: NTGCGTGGGCGK; match class: 1 | 57 | 7.964942e-03 | 0 |
| TF | TF:M02036 | Factor: WT1; motif: CGCCCCCNCN | Factor: WT1; motif: CGCCCCCNCN | 163 | 8.561214e-03 | 0 |
| TF | TF:M02052 | Factor: EHF; motif: CSCGGAARTN | Factor: EHF; motif: CSCGGAARTN | 166 | 8.852504e-03 | 0 |
| TF | TF:M08309_1 | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN; match class: 1 | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN; match class: 1 | 127 | 8.906015e-03 | 0 |
| TF | TF:M00144_1 | Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM; match class: 1 | Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM; match class: 1 | 128 | 8.960986e-03 | 0 |
| TF | TF:M12152 | Factor: Sp1; motif: NWRGCCACGCCCMCN | Factor: Sp1; motif: NWRGCCACGCCCMCN | 131 | 8.980427e-03 | 0 |
| TF | TF:M08313 | Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR | Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR | 226 | 9.134249e-03 | 0 |
| TF | TF:M02090_1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | 118 | 9.235894e-03 | 0 |
| TF | TF:M04519 | Factor: E2F-4; motif: TTTGGCGCCAAA | Factor: E2F-4; motif: TTTGGCGCCAAA | 95 | 9.488443e-03 | 0 |
| TF | TF:M00428_1 | Factor: E2F-1; motif: NKTSSCGC; match class: 1 | Factor: E2F-1; motif: NKTSSCGC; match class: 1 | 77 | 9.696671e-03 | 0 |
| TF | TF:M12666_1 | Factor: SP1; motif: GGCCCCGCCCCCN; match class: 1 | Factor: SP1; motif: GGCCCCGCCCCCN; match class: 1 | 89 | 9.749795e-03 | 0 |
| TF | TF:M07039 | Factor: ETF; motif: CCCCGCCCCYN | Factor: ETF; motif: CCCCGCCCCYN | 236 | 1.010520e-02 | 0 |
| TF | TF:M04515_1 | Factor: E2F-1; motif: WWTGGCGCCAAA; match class: 1 | Factor: E2F-1; motif: WWTGGCGCCAAA; match class: 1 | 192 | 1.031244e-02 | 0 |
| TF | TF:M11528 | Factor: E2F-2; motif: NTTTTGGCGCCAWWWN | Factor: E2F-2; motif: NTTTTGGCGCCAWWWN | 170 | 1.089065e-02 | 0 |
| TF | TF:M03925 | Factor: YY2; motif: NCCGCCATNTY | Factor: YY2; motif: NCCGCCATNTY | 92 | 1.119594e-02 | 0 |
| TF | TF:M04748_1 | Factor: GABP-alpha; motif: AACCGGAAR; match class: 1 | Factor: GABP-alpha; motif: AACCGGAAR; match class: 1 | 169 | 1.154334e-02 | 0 |
| TF | TF:M13135_1 | Factor: SP4; motif: GGCCCCGCCCCCN; match class: 1 | Factor: SP4; motif: GGCCCCGCCCCCN; match class: 1 | 54 | 1.166649e-02 | 0 |
| TF | TF:M08911 | Factor: CTCF; motif: NCCRSTAGGGGGCGC | Factor: CTCF; motif: NCCRSTAGGGGGCGC | 154 | 1.168708e-02 | 0 |
| TF | TF:M03807_1 | Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 | Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 | 86 | 1.197925e-02 | 0 |
| TF | TF:M01588_1 | Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 | Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 | 82 | 1.201106e-02 | 0 |
| TF | TF:M03811 | Factor: AP-2gamma; motif: GCCYNCRGSN | Factor: AP-2gamma; motif: GCCYNCRGSN | 150 | 1.252521e-02 | 0 |
| TF | TF:M03567_1 | Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 | Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 | 77 | 1.279796e-02 | 0 |
| TF | TF:M13135 | Factor: SP4; motif: GGCCCCGCCCCCN | Factor: SP4; motif: GGCCCCGCCCCCN | 106 | 1.281258e-02 | 0 |
| TF | TF:M00024_1 | Factor: E2F-1; motif: TWSGCGCGAAAAYKR; match class: 1 | Factor: E2F-1; motif: TWSGCGCGAAAAYKR; match class: 1 | 61 | 1.298082e-02 | 0 |
| TF | TF:M07277 | Factor: BTEB2; motif: RGGGNGKGGN | Factor: BTEB2; motif: RGGGNGKGGN | 146 | 1.324785e-02 | 0 |
| TF | TF:M08226_1 | Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 | Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 | 106 | 1.395227e-02 | 0 |
| TF | TF:M10071 | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG | 146 | 1.471782e-02 | 0 |
| TF | TF:M12592 | Factor: CREM; motif: NRTGACGYMA | Factor: CREM; motif: NRTGACGYMA | 117 | 1.480334e-02 | 0 |
| TF | TF:M13031 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 174 | 1.522294e-02 | 0 |
| TF | TF:M09970_1 | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 | 79 | 1.550884e-02 | 0 |
| TF | TF:M04691 | Factor: Kaiso; motif: TCTCGCGAG | Factor: Kaiso; motif: TCTCGCGAG | 223 | 1.680256e-02 | 0 |
| TF | TF:M07395 | Factor: Sp1; motif: NGGGGCGGGGN | Factor: Sp1; motif: NGGGGCGGGGN | 173 | 1.744148e-02 | 0 |
| TF | TF:M01104 | Factor: MOVO-B; motif: GNGGGGG | Factor: MOVO-B; motif: GNGGGGG | 168 | 1.774596e-02 | 0 |
| TF | TF:M08209_1 | Factor: E2F-3:FOXO6; motif: NAATGACACGCGCCCMC; match class: 1 | Factor: E2F-3:FOXO6; motif: NAATGACACGCGCCCMC; match class: 1 | 136 | 1.792887e-02 | 0 |
| TF | TF:M11882_1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | 182 | 1.865229e-02 | 0 |
| TF | TF:M10098 | Factor: DP-1; motif: NRNNGGCGGGAANN | Factor: DP-1; motif: NRNNGGCGGGAANN | 126 | 1.918888e-02 | 0 |
| TF | TF:M02064 | Factor: c-ets-2; motif: ACCGGAWRTN | Factor: c-ets-2; motif: ACCGGAWRTN | 175 | 2.051430e-02 | 0 |
| TF | TF:M00025 | Factor: Elk-1; motif: NNNNCCGGAARTNN | Factor: Elk-1; motif: NNNNCCGGAARTNN | 164 | 2.139009e-02 | 0 |
| TF | TF:M12697 | Factor: ZNF142; motif: SNSCGCCCGCCCGCSCSS | Factor: ZNF142; motif: SNSCGCCCGCCCGCSCSS | 68 | 2.164817e-02 | 0 |
| TF | TF:M00245 | Factor: Egr-3; motif: NTGCGTGGGCGK | Factor: Egr-3; motif: NTGCGTGGGCGK | 129 | 2.193325e-02 | 0 |
| TF | TF:M09895 | Factor: E2F-6; motif: NGGGCGGGARRNN | Factor: E2F-6; motif: NGGGCGGGARRNN | 136 | 2.214266e-02 | 0 |
| TF | TF:M13147 | Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN | Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN | 177 | 2.448014e-02 | 0 |
| TF | TF:M12722_1 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS; match class: 1 | 120 | 2.460686e-02 | 0 |
| TF | TF:M00932_1 | Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 | Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 | 112 | 2.477283e-02 | 0 |
| TF | TF:M10530 | Factor: sp4; motif: NNNGCYCCGCCCCCY | Factor: sp4; motif: NNNGCYCCGCCCCCY | 141 | 2.493909e-02 | 0 |
| TF | TF:M10121 | Factor: ZFX; motif: SNAGGCCNCR | Factor: ZFX; motif: SNAGGCCNCR | 81 | 2.586643e-02 | 0 |
| TF | TF:M13124 | Factor: ZNF670; motif: SNGGGCRGRG | Factor: ZNF670; motif: SNGGGCRGRG | 197 | 2.599967e-02 | 0 |
| TF | TF:M02059 | Factor: ELK-1; motif: ACCGGAAGTN | Factor: ELK-1; motif: ACCGGAAGTN | 156 | 2.651645e-02 | 0 |
| TF | TF:M09834 | Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN | Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN | 124 | 2.701324e-02 | 0 |
| TF | TF:M00196_1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | 110 | 2.769493e-02 | 0 |
| TF | TF:M08309 | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN | Factor: GCMa:Elk-1; motif: RTGNGGGCGGAAGNN | 196 | 2.964066e-02 | 0 |
| TF | TF:M01820 | Factor: CREM; motif: TGACGTCASYN | Factor: CREM; motif: TGACGTCASYN | 114 | 3.056869e-02 | 0 |
| TF | TF:M11882 | Factor: pax-6; motif: NYACGCNYSANYGMNCN | Factor: pax-6; motif: NYACGCNYSANYGMNCN | 226 | 3.196866e-02 | 0 |
| TF | TF:M12151 | Factor: Sp1; motif: NWRGCCMCGCCCMCN | Factor: Sp1; motif: NWRGCCMCGCCCMCN | 122 | 3.243616e-02 | 0 |
| TF | TF:M00004_1 | Factor: c-Myb; motif: NCNRNNGRCNGTTGGKGG; match class: 1 | Factor: c-Myb; motif: NCNRNNGRCNGTTGGKGG; match class: 1 | 46 | 3.355951e-02 | 0 |
| TF | TF:M01240_1 | Factor: BEN; motif: CAGCGRNV; match class: 1 | Factor: BEN; motif: CAGCGRNV; match class: 1 | 202 | 3.372579e-02 | 0 |
| TF | TF:M12227_1 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 | 109 | 3.600706e-02 | 0 |
| TF | TF:M11427 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 170 | 4.123322e-02 | 0 |
| TF | TF:M10006 | Factor: NF-YC; motif: NNRRCCAATCAGNR | Factor: NF-YC; motif: NNRRCCAATCAGNR | 57 | 4.296308e-02 | 0 |
| TF | TF:M03807 | Factor: SP2; motif: GNNGGGGGCGGGGSN | Factor: SP2; motif: GNNGGGGGCGGGGSN | 143 | 4.546454e-02 | 0 |
| TF | TF:M01588 | Factor: GKLF; motif: GCCMCRCCCNNN | Factor: GKLF; motif: GCCMCRCCCNNN | 149 | 4.649187e-02 | 0 |
| TF | TF:M07302 | Factor: NF-Y; motif: RGCCAATCRGN | Factor: NF-Y; motif: RGCCAATCRGN | 41 | 4.682082e-02 | 0 |
| TF | TF:M12643 | Factor: NFYB; motif: RGCCAATSRGNRNNNNSNG | Factor: NFYB; motif: RGCCAATSRGNRNNNNSNG | 48 | 4.683124e-02 | 0 |
| TF | TF:M13366_1 | Factor: ZBED4; motif: CCCGCYCCGC; match class: 1 | Factor: ZBED4; motif: CCCGCYCCGC; match class: 1 | 78 | 4.697755e-02 | 0 |
| TF | TF:M11400_1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | 83 | 4.850020e-02 | 0 |
| TF | TF:M04950 | Factor: Egr-1; motif: NGCGTGCGY | Factor: Egr-1; motif: NGCGTGCGY | 174 | 4.888246e-02 | 0 |
| TF | TF:M12516 | Factor: E2F6; motif: NNNGGCGGGAANN | Factor: E2F6; motif: NNNGGCGGGAANN | 77 | 4.891454e-02 | 0 |
| TF | TF:M11401_1 | Factor: Fli-1; motif: NACCGGATATCCGGTN; match class: 1 | Factor: Fli-1; motif: NACCGGATATCCGGTN; match class: 1 | 184 | 4.996314e-02 | 0 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002894 | Neoplasm of the pancreas | A tumor (abnormal growth of tissue) of the pancreas. | 17 | 2.458089e-10 | 0 |
| HP | HP:0011792 | Neoplasm by histology | Neoplasm categorized according to type of histological abnormality. | 28 | 2.763663e-08 | 0 |
| HP | HP:0010785 | Gonadal neoplasm | A tumor (abnormal growth of tissue) of a gonad. | 16 | 5.584832e-08 | 0 |
| HP | HP:0000769 | Abnormality of the breast | An abnormality of the breast. | 31 | 6.303763e-08 | 0 |
| HP | HP:0010460 | Abnormality of the female genitalia | Abnormality of the female genital system. | 34 | 2.001388e-07 | 0 |
| HP | HP:0010787 | Genital neoplasm | A tumor (abnormal growth of tissue) of the genital system. | 18 | 3.454240e-07 | 0 |
| HP | HP:0000812 | Abnormal internal genitalia | An anomaly of the adnexa, uterus, and vagina (in female) or seminal tract and prostate (in male). | 33 | 3.977416e-07 | 0 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 21 | 1.264456e-06 | 0 |
| HP | HP:0030406 | Primary peritoneal carcinoma | A type of cancer that originates in the peritoneum. It is to be distinguished from metastatic cancer of the peritoneum. Peritoneal cancer can occur anywhere in the abdominal space, and affects the surface of organs contained inside the peritoneum. | 7 | 3.271217e-06 | 0 |
| HP | HP:0007378 | Neoplasm of the gastrointestinal tract | A tumor (abnormal growth of tissue) of the gastrointestinal tract. | 23 | 4.038366e-06 | 0 |
| HP | HP:0000008 | Abnormal morphology of female internal genitalia | An abnormality of the female internal genitalia. | 29 | 4.652054e-06 | 0 |
| HP | HP:0031093 | Abnormal breast morphology | Any anomaly of the structure of the breast. | 28 | 5.911316e-06 | 0 |
| HP | HP:0000130 | Abnormality of the uterus | An abnormality of the uterus. | 21 | 7.744926e-06 | 0 |
| HP | HP:0007400 | Irregular hyperpigmentation | Irregular hyperpigmentation | 20 | 1.276230e-05 | 0 |
| HP | HP:0100783 | Breast aplasia | Failure to develop and congenital absence of the breast. | 7 | 1.771532e-05 | 0 |
| HP | HP:0100013 | Neoplasm of the breast | A tumor (abnormal growth of tissue) of the breast. | 13 | 2.630525e-05 | 0 |
| HP | HP:0002861 | Melanoma | The presence of a melanoma, a malignant cancer originating from pigment producing melanocytes. Melanoma can originate from the skin or the pigmented layers of the eye (the uvea). | 12 | 3.024508e-05 | 0 |
| HP | HP:0034930 | Digestive system neoplasm | A tumor (abnormal growth of tissue) of the digestive system. | 24 | 3.176955e-05 | 0 |
| HP | HP:0100615 | Ovarian neoplasm | A tumor (abnormal growth of tissue) of the ovary. | 11 | 1.376449e-04 | 0 |
| HP | HP:0030063 | Neuroepithelial neoplasm | A neoplasm composed of neural epithelium, not necessarily a neoplasm located in the neural epithelium or neuroepithelium. | 12 | 1.518816e-04 | 0 |
| HP | HP:0030061 | Neuroectodermal neoplasm | A neoplasm arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells. | 12 | 1.717605e-04 | 0 |
| HP | HP:0030060 | Nervous tissue neoplasm | A neoplasm derived from nervous tissue (not necessarily a neoplasm located in the nervous system). | 12 | 1.717605e-04 | 0 |
| HP | HP:0100006 | Neoplasm of the central nervous system | A neoplasm of the central nervous system. | 16 | 1.980207e-04 | 0 |
| HP | HP:0006753 | Neoplasm of the stomach | A tumor (abnormal growth of tissue) of the stomach. | 11 | 5.254563e-04 | 0 |
| HP | HP:0000240 | Abnormality of skull size | Any abnormality of the size of the skull. | 54 | 5.459927e-04 | 0 |
| HP | HP:0000059 | Hypoplastic labia majora | Undergrowth of the outer labia. | 8 | 5.635146e-04 | 0 |
| HP | HP:0000953 | Hyperpigmentation of the skin | A darkening of the skin related to an increase in melanin production and deposition. | 21 | 6.010834e-04 | 0 |
| HP | HP:0011027 | Abnormal fallopian tube morphology | An abnormality of the fallopian tube. | 7 | 6.955168e-04 | 0 |
| HP | HP:0004375 | Neoplasm of the nervous system | A tumor (abnormal growth of tissue) of the nervous system. | 16 | 7.037094e-04 | 0 |
| HP | HP:0012334 | Extrahepatic cholestasis | Impairment of bile flow due to obstruction in large bile ducts outside the liver. | 5 | 8.156050e-04 | 0 |
| HP | HP:0002246 | Abnormal duodenum morphology | An abnormality of the duodenum, i.e., the first section of the small intestine. | 11 | 8.520368e-04 | 0 |
| HP | HP:0003002 | Breast carcinoma | The presence of a carcinoma of the breast. | 10 | 9.436187e-04 | 0 |
| HP | HP:0001034 | Hypermelanotic macule | A hyperpigmented circumscribed area of change in normal skin color without elevation or depression of any size. | 16 | 9.952277e-04 | 0 |
| HP | HP:0030310 | Upper extremity joint dislocation | Displacement or malalignment of one or more joints in the upper extremity (arm). | 11 | 1.074402e-03 | 0 |
| HP | HP:0004097 | Deviation of finger | Deviated fingers is a term that should be used if one or more fingers of the hand are deviated from their normal position, either to the radial or ulnar side. A deviation of a finger can be caused by an abnormal form of one or more of the phalanges of the affected finger, or by a deviation or displacement of one or more phalanges. | 27 | 1.257766e-03 | 0 |
| HP | HP:0031105 | Abnormal uterus morphology | Any anomaly of the structure of the uterus | 14 | 1.271248e-03 | 0 |
| HP | HP:0011267 | Microtia, third degree | Presence of some auricular structures, but none of these structures conform to recognized ear components. | 5 | 1.473452e-03 | 0 |
| HP | HP:0002588 | Duodenal ulcer | An erosion of the mucous membrane in a portion of the duodenum. | 5 | 2.489061e-03 | 0 |
| HP | HP:0004209 | Clinodactyly of the 5th finger | Clinodactyly refers to a bending or curvature of the fifth finger in the radial direction (i.e., towards the 4th finger). | 23 | 2.544405e-03 | 0 |
| HP | HP:0100836 | Malignant neoplasm of the central nervous system | A tumor that originates in the pineal gland, has moderate cellularity and tends to form rosette patterns. | 11 | 2.562088e-03 | 0 |
| HP | HP:0040019 | Finger clinodactyly | Finger clinodactyly | 24 | 2.567210e-03 | 0 |
| HP | HP:0009179 | Deviation of the 5th finger | Displacement of the 5th finger from its normal position. | 23 | 2.652450e-03 | 0 |
| HP | HP:0012881 | Abnormal labia majora morphology | An anomaly of the outer labia. | 8 | 2.663013e-03 | 0 |
| HP | HP:0010786 | Urinary tract neoplasm | The presence of a neoplasm of the urinary system. | 13 | 2.829913e-03 | 0 |
| HP | HP:0003042 | Elbow dislocation | Dislocation of the distal humerus out of the elbow joint, where the radius, ulna, and humerus meet. | 10 | 2.934132e-03 | 0 |
| HP | HP:0001824 | Weight loss | Reduction of total body weight. | 22 | 3.029905e-03 | 0 |
| HP | HP:0012125 | Prostate cancer | A cancer of the prostate. | 7 | 3.056227e-03 | 0 |
| HP | HP:0100787 | Prostate neoplasm | Prostate neoplasm | 7 | 3.056227e-03 | 0 |
| HP | HP:0009484 | Deviation of the hand or of fingers of the hand | Displacement of the hand or of fingers of the hand from their normal position. | 27 | 3.337625e-03 | 0 |
| HP | HP:0011024 | Abnormality of the gastrointestinal tract | An abnormality of the gastrointestinal tract. | 55 | 3.377249e-03 | 0 |
| HP | HP:0009733 | Glioma | The presence of a glioma, which is a neoplasm of the central nervous system originating from a glial cell (astrocytes or oligodendrocytes). | 8 | 3.736028e-03 | 0 |
| HP | HP:0009939 | Mandibular aplasia | Absence of the mandible. | 5 | 3.985721e-03 | 0 |
| HP | HP:0100835 | Benign neoplasm of the central nervous system | Benign neoplasm of the central nervous system | 11 | 4.655467e-03 | 0 |
| HP | HP:0000524 | Conjunctival telangiectasia | The presence of small (ca. 0.5-1.0 mm) dilated blood vessels near the surface of the mucous membranes of the conjunctiva. | 6 | 4.782256e-03 | 0 |
| HP | HP:0002664 | Neoplasm | An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor). | 37 | 5.090264e-03 | 0 |
| HP | HP:0012443 | Abnormal brain morphology | A structural abnormality of the brain, which has as its parts the forebrain, midbrain, and hindbrain. | 71 | 5.927059e-03 | 0 |
| HP | HP:0000202 | Orofacial cleft | The presence of a cleft (gap, opening, or groove) in the oral cavity, including cleft of the upper lip and/or cleft of the palate. Cleft of the upper lip is visible as a groove or fissure in the lip, most frequently due to a congenital failure of the maxillary and median nasal processes to fuse. Cleft palate is characterized by a grooved depression or fissure in the roof of the mouth, most often resulting from a congenital failure of the palate to fuse properly. Clefts of the lip and palate can occur individually or together. It is preferable to code each defect separately. | 29 | 6.095047e-03 | 0 |
| HP | HP:0009892 | Anotia | Complete absence of any auricular structures. | 5 | 6.109592e-03 | 0 |
| HP | HP:5201015 | Craniofacial cleft | Congenital abnormality with cleft (gap or opening) in the craniofacial bones. Craniofacial cleft includes facial cleft, orofacial clef, and cleft of the jaw. | 29 | 7.118710e-03 | 0 |
| HP | HP:0011793 | Neoplasm by anatomical site | Neoplasm categorized according to the anatomical site of origin of the neoplasm. | 36 | 7.761363e-03 | 0 |
| HP | HP:0012432 | Chronic fatigue | Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer. | 6 | 8.142985e-03 | 0 |
| HP | HP:0012733 | Macule | A flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin. | 16 | 9.028149e-03 | 0 |
| HP | HP:0001732 | Abnormality of the pancreas | An abnormality of the pancreas. | 19 | 9.063971e-03 | 0 |
| HP | HP:0001373 | Joint dislocation | Displacement or malalignment of joints. | 21 | 9.832660e-03 | 0 |
| HP | HP:0000022 | Abnormal male internal genitalia morphology | An abnormality of the male internal genitalia. | 10 | 1.070448e-02 | 0 |
| HP | HP:0009726 | Renal neoplasm | The presence of a neoplasm of the kidney. | 12 | 1.175531e-02 | 0 |
| HP | HP:0002242 | Abnormal intestine morphology | An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine. | 31 | 1.224748e-02 | 0 |
| HP | HP:0000252 | Microcephaly | Head circumference below 2 standard deviations below the mean for age and gender. | 45 | 1.226000e-02 | 0 |
| HP | HP:0030445 | Pulmonary carcinoid tumor | A malignant neuroendocrine tumor of the lung. According to histopathologic criteria (WHO 2004), carcinoids are divided into four groups i.e. typical and atypical carcinoids, large cell neuroendocrine carcinoma and small cell lung carcinoma. | 4 | 1.298995e-02 | 0 |
| HP | HP:0008054 | Abnormal morphology of the conjunctival vasculature | Any abnormality of the blood vessels of the conjunctiva. | 6 | 1.320996e-02 | 0 |
| HP | HP:0012718 | Abnormal gastrointestinal tract morphology | Abnormal structure of the gastrointestinal tract. | 36 | 1.383427e-02 | 0 |
| HP | HP:0008775 | Abnormal prostate morphology | An abnormality of the prostate. | 7 | 1.425526e-02 | 0 |
| HP | HP:0040195 | Decreased head circumference | An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean. | 45 | 1.611090e-02 | 0 |
| HP | HP:0000413 | Atresia of the external auditory canal | Absence or failure to form of the external auditory canal. | 8 | 1.630687e-02 | 0 |
| HP | HP:0000175 | Cleft palate | Cleft palate is a developmental defect of the palate resulting from a failure of fusion of the palatine processes and manifesting as a separation of the roof of the mouth (soft and hard palate). | 27 | 1.661158e-02 | 0 |
| HP | HP:0000347 | Micrognathia | Developmental hypoplasia of the mandible. | 33 | 1.756595e-02 | 0 |
| HP | HP:0009118 | Aplasia/Hypoplasia of the mandible | Absence or underdevelopment of the mandible. | 33 | 1.849768e-02 | 0 |
| HP | HP:0100242 | Sarcoma | A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant. | 13 | 1.857627e-02 | 0 |
| HP | HP:0004207 | Abnormal 5th finger morphology | An abnormality affecting one or both 5th fingers. | 24 | 1.998071e-02 | 0 |
| HP | HP:0001000 | Abnormality of skin pigmentation | An abnormality of the pigmentation of the skin. | 24 | 1.998071e-02 | 0 |
| HP | HP:0000039 | Epispadias | Epispadias is a urogenital malformation characterized by the failure of the urethral tube to tubularize on the dorsal aspect. Unlike in hypospadias, where the meatus is on the ventral aspect, children with epispadias have a wide-open urethral plate on the dorsum. It is commonly seen as a component in the spectrum of bladder exstrophy-epispadias-complex. Isolated epispadias constitutes less than 10 percent of the total cases of epispadias. | 6 | 2.057506e-02 | 0 |
| HP | HP:0000002 | Abnormality of body height | Deviation from the norm of height with respect to that which is expected according to age and gender norms. | 48 | 2.229720e-02 | 0 |
| HP | HP:0008261 | Pancreatic islet cell adenoma | The presence of an adenoma of the pancreas with origin in a pancreatic B cell. | 4 | 2.305083e-02 | 0 |
| HP | HP:0009116 | Aplasia/Hypoplasia involving bones of the skull | Aplasia/Hypoplasia involving bones of the skull | 33 | 2.328364e-02 | 0 |
| HP | HP:0012745 | Short palpebral fissure | Distance between the medial and lateral canthi is more than 2 SD below the mean for age (objective); or, apparently reduced length of the palpebral fissures. | 11 | 2.408970e-02 | 0 |
| HP | HP:0000320 | Bird-like facies | Bird-like facies | 5 | 2.465608e-02 | 0 |
| HP | HP:0006744 | Adrenocortical carcinoma | A malignant neoplasm of the adrenal cortex that may produce hormones such as cortisol, aldosterone, estrogen, or testosterone. | 5 | 2.465608e-02 | 0 |
| HP | HP:0001442 | Typified by somatic mosaicism | Description of conditions in which affected individuals typically display somatic mosaicism, i.e., genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations. In many conditions typified by somatic mosaicism, constitutive mutation is lethal and cases are exclusively or predominantly mosaic. | 13 | 2.556916e-02 | 0 |
| HP | HP:0003072 | Hypercalcemia | An abnormally increased calcium concentration in the blood. | 9 | 2.689079e-02 | 0 |
| HP | HP:0033019 | Male reproductive system neoplasm | A neoplasm that affects the male reproductive system. | 8 | 2.707144e-02 | 0 |
| HP | HP:0000066 | Labial hypoplasia | Labial hypoplasia | 8 | 2.707144e-02 | 0 |
| HP | HP:0002088 | Abnormal lung morphology | Any structural anomaly of the lung. | 42 | 2.779231e-02 | 0 |
| HP | HP:0000172 | Abnormal uvula morphology | Abnormality of the uvula, the conic projection from the posterior edge of the middle of the soft palate. | 14 | 2.779884e-02 | 0 |
| HP | HP:0012243 | Abnormal reproductive system morphology | A structural or developmental anomaly of any of the tissues involved in the genital system. | 45 | 2.913500e-02 | 0 |
| HP | HP:0001551 | Abnormal umbilicus morphology | An abnormality of the structure or appearance of the umbilicus. | 18 | 2.988436e-02 | 0 |
| HP | HP:0002011 | Morphological central nervous system abnormality | A structural abnormality of the central nervous system. | 73 | 3.015370e-02 | 0 |
| HP | HP:0006740 | Transitional cell carcinoma of the bladder | The presence of a carcinoma of the urinary bladder with origin in a transitional epithelial cell. | 6 | 3.095362e-02 | 0 |
| HP | HP:0100790 | Hernia | Hernia | 26 | 3.159555e-02 | 0 |
| HP | HP:0006660 | Aplastic clavicle | Absence of the clavicles as a developmental defect. | 5 | 3.297450e-02 | 0 |
| HP | HP:0006716 | Hereditary nonpolyposis colorectal carcinoma | Hereditary nonpolyposis colorectal carcinoma | 6 | 3.753264e-02 | 0 |
| HP | HP:0005249 | Functional intestinal obstruction | Functional intestinal obstruction | 4 | 3.787431e-02 | 0 |
| HP | HP:0000058 | Abnormal labia morphology | An anomaly of the labia, the externally visible portions of the vulva. | 9 | 3.993417e-02 | 0 |
| HP | HP:0002705 | High, narrow palate | The presence of a high and narrow palate. | 12 | 4.172209e-02 | 0 |
| HP | HP:0000078 | Abnormality of the genital system | An abnormality of the genital system. | 51 | 4.324233e-02 | 0 |
| HP | HP:0031207 | Hepatic hemangioma | A congenital vascular malformation in the liver composed of masses of blood vessels that are atypical or irregular in arrangement and size. | 3 | 4.325718e-02 | 0 |
| HP | HP:0410266 | Visceral hemangioma | A hemangioma arising from within visceral structures, the internal organs of the body. | 3 | 4.325718e-02 | 0 |
| HP | HP:0012815 | Hypoplastic female external genitalia | Underdevelopment of part or all of the female external reproductive organs (which include the mons pubis, labia majora, labia minora, Bartholin glands, and clitoris). | 8 | 4.328127e-02 | 0 |
| HP | HP:0000160 | Narrow mouth | Distance between the commissures of the mouth more than 2 SD below the mean. Alternatively, an apparently decreased width of the oral aperture (subjective). | 15 | 4.450791e-02 | 0 |
| HP | HP:0002862 | Bladder carcinoma | The presence of a carcinoma of the urinary bladder. | 6 | 4.519407e-02 | 0 |
| HP | HP:0006725 | Pancreatic adenocarcinoma | The presence of an adenocarcinoma of the pancreas. | 6 | 4.519407e-02 | 0 |
| HP | HP:0002797 | Osteolysis | Osteolysis refers to the destruction of bone through bone resorption with removal or loss of calcium. | 9 | 4.825783e-02 | 0 |
| HP | HP:0030084 | Clinodactyly | An angulation of a digit at an interphalangeal joint in the plane of the palm (finger) or sole (toe). | 25 | 4.827767e-02 | 0 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1474 | SMAD3/4-E2F4/5-p107-DP1 complex | SMAD3/4-E2F4/5-p107-DP1 complex | 6 | 6.659755e-07 | 0 |
| CORUM | CORUM:433 | BASC complex (BRCA1-associated genome surveillance complex) | BASC complex (BRCA1-associated genome surveillance complex) | 7 | 1.647248e-05 | 0 |
| CORUM | CORUM:2975 | SMAD3-E2F4/5-p107-DP1 complex | SMAD3-E2F4/5-p107-DP1 complex | 5 | 1.799732e-05 | 0 |
| CORUM | CORUM:1005 | RC complex during G2/M-phase of cell cycle | RC complex during G2/M-phase of cell cycle | 6 | 1.230721e-04 | 0 |
| CORUM | CORUM:964 | BRCA1-RAD50-MRE11-NBS1 complex | BRCA1-RAD50-MRE11-NBS1 complex | 4 | 4.826425e-04 | 0 |
| CORUM | CORUM:202 | BRCA1-RAD50-MRE11-NBS1 complex | BRCA1-RAD50-MRE11-NBS1 complex | 4 | 4.826425e-04 | 0 |
| CORUM | CORUM:310 | Cell cycle kinase complex CDC2 | Cell cycle kinase complex CDC2 | 4 | 4.826425e-04 | 0 |
| CORUM | CORUM:2210 | BRCA1-IRIS-pre-replication complex | BRCA1-IRIS-pre-replication complex | 4 | 4.826425e-04 | 0 |
| CORUM | CORUM:2815 | BRCA1-BARD1-BACH1-DNA damage complex II | BRCA1-BARD1-BACH1-DNA damage complex II | 5 | 9.175168e-04 | 0 |
| CORUM | CORUM:1003 | RC complex (Replication competent complex) | RC complex (Replication competent complex) | 5 | 9.175168e-04 | 0 |
| CORUM | CORUM:1036 | TFIIH transcription factor complex | TFIIH transcription factor complex | 5 | 2.000880e-03 | 0 |
| CORUM | CORUM:1107 | DNA synthesome core complex | DNA synthesome core complex | 5 | 2.000880e-03 | 0 |
| CORUM | CORUM:107 | TFIIH transcription factor complex | TFIIH transcription factor complex | 5 | 2.000880e-03 | 0 |
| CORUM | CORUM:1004 | RC complex during S-phase of cell cycle | RC complex during S-phase of cell cycle | 5 | 2.000880e-03 | 0 |
| CORUM | CORUM:1029 | TFIIH transcription factor complex | TFIIH transcription factor complex | 5 | 3.878687e-03 | 0 |
| CORUM | CORUM:1098 | DNA synthesome complex (13 subunits) | DNA synthesome complex (13 subunits) | 5 | 3.878687e-03 | 0 |
| CORUM | CORUM:1009 | TFIIH transcription factor complex | TFIIH transcription factor complex | 5 | 3.878687e-03 | 0 |
| CORUM | CORUM:5596 | LINC complex, quiescent cells | LINC complex, quiescent cells | 4 | 6.814361e-03 | 0 |
| CORUM | CORUM:3015 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | 4 | 6.814361e-03 | 0 |
| CORUM | CORUM:5118 | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) | 4 | 6.814361e-03 | 0 |
| CORUM | CORUM:73 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:71 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:5144 | E2F1-p107-cyclinA complex | E2F1-p107-cyclinA complex | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:6300 | CDKN1A-TP53-CDK1-PCNA complex | CDKN1A-TP53-CDK1-PCNA complex | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:1081 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:6589 | E2F-1-DP-1-cyclinA-CDK2 complex | E2F-1-DP-1-cyclinA-CDK2 complex | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:1661 | E2F4-p107-cyclinA complex | E2F4-p107-cyclinA complex | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:618 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:2818 | BRCA1-BARD1-BRCA2-DNA damage complex III | BRCA1-BARD1-BRCA2-DNA damage complex III | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:2767 | RAD50-MRE11-NBN-p200-p350 complex | RAD50-MRE11-NBN-p200-p350 complex | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:3753 | CREBBP-SMAD2-SMAD4 pentameric complex | CREBBP-SMAD2-SMAD4 pentameric complex | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:2834 | SMAD4-SMAD2-SMAD3 complex | SMAD4-SMAD2-SMAD3 complex | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:1173 | TIP49-TIP48-BAF53 complex | TIP49-TIP48-BAF53 complex | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:972 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:331 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:2706 | SMAD3-SMAD4-SP1 complex | SMAD3-SMAD4-SP1 complex | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:3754 | CREBBP-SMAD3-SMAD4 pentameric complex | CREBBP-SMAD3-SMAD4 pentameric complex | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:173 | MRN complex (MRE11-RAD50-NBN complex) | MRN complex (MRE11-RAD50-NBN complex) | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:1473 | E2F5-RB2-DP1 complex | E2F5-RB2-DP1 complex | 3 | 1.284513e-02 | 0 |
| CORUM | CORUM:1108 | DNA synthesome complex (15 subunits) | DNA synthesome complex (15 subunits) | 5 | 1.803937e-02 | 0 |
| CORUM | CORUM:1111 | DNA synthesome complex (17 subunits) | DNA synthesome complex (17 subunits) | 5 | 2.720063e-02 | 0 |
| CORUM | CORUM:1099 | DNA synthesome complex (17 subunits) | DNA synthesome complex (17 subunits) | 5 | 2.720063e-02 | 0 |
| CORUM | CORUM:434 | BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) | BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) | 4 | 2.993616e-02 | 0 |
| CORUM | CORUM:1030 | CAK-ERCC2 complex | CAK-ERCC2 complex | 3 | 4.993259e-02 | 0 |
| CORUM | CORUM:627 | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) | 3 | 4.993259e-02 | 0 |
| CORUM | CORUM:1827 | PML-SMAD2/3-SARA complex | PML-SMAD2/3-SARA complex | 3 | 4.993259e-02 | 0 |
| CORUM | CORUM:619 | MRE11A-RAD50-NBN-TRF2 complex | MRE11A-RAD50-NBN-TRF2 complex | 3 | 4.993259e-02 | 0 |
| CORUM | CORUM:4 | Multisubunit ACTR coactivator complex | Multisubunit ACTR coactivator complex | 3 | 4.993259e-02 | 0 |
| CORUM | CORUM:2218 | MDC1-MRE11-RAD50-NBS1 complex | MDC1-MRE11-RAD50-NBS1 complex | 3 | 4.993259e-02 | 0 |
| CORUM | CORUM:2660 | CAK-ERCC2 complex | CAK-ERCC2 complex | 3 | 4.993259e-02 | 0 |
Community 1
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 116 | 9.426613e-54 | 1 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 116 | 4.262391e-53 | 1 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 116 | 4.480360e-53 | 1 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 116 | 4.480360e-53 | 1 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 141 | 1.982640e-44 | 1 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 224 | 1.799253e-41 | 1 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 120 | 9.558534e-37 | 1 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 125 | 2.194260e-29 | 1 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 133 | 4.722858e-23 | 1 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 226 | 1.655016e-22 | 1 |
| GO:CC | GO:0031090 | organelle membrane | "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] | 107 | 1.268424e-21 | 1 |
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 72 | 6.987837e-21 | 1 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 228 | 3.282887e-18 | 1 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 232 | 8.247224e-18 | 1 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 113 | 1.200180e-16 | 1 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 76 | 3.192018e-15 | 1 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 76 | 3.647991e-15 | 1 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 209 | 4.241235e-14 | 1 |
| GO:CC | GO:0031967 | organelle envelope | "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] | 50 | 7.803345e-13 | 1 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 217 | 1.114981e-12 | 1 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 17 | 1.559740e-12 | 1 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 17 | 1.559740e-12 | 1 |
| GO:CC | GO:0005759 | mitochondrial matrix | "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] | 31 | 1.672347e-12 | 1 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 162 | 8.733405e-12 | 1 |
| GO:CC | GO:0098588 | bounding membrane of organelle | "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] | 64 | 2.544349e-11 | 1 |
| GO:CC | GO:0031966 | mitochondrial membrane | "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] | 35 | 2.359036e-10 | 1 |
| GO:CC | GO:0005783 | endoplasmic reticulum | "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] | 59 | 4.955094e-10 | 1 |
| GO:CC | GO:0005740 | mitochondrial envelope | "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] | 35 | 1.350002e-09 | 1 |
| GO:CC | GO:0005743 | mitochondrial inner membrane | "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] | 27 | 2.822464e-09 | 1 |
| GO:CC | GO:0019866 | organelle inner membrane | "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] | 28 | 5.703154e-09 | 1 |
| GO:CC | GO:0140534 | endoplasmic reticulum protein-containing complex | "A protein complex that is part of an endoplasmic reticulum." [GOC:pg] | 14 | 8.478326e-09 | 1 |
| GO:CC | GO:0098796 | membrane protein complex | "Any protein complex that is part of a membrane." [GOC:dos] | 44 | 1.800317e-08 | 1 |
| GO:CC | GO:0042645 | mitochondrial nucleoid | "The region of a mitochondrion to which the DNA is confined." [GOC:jl] | 10 | 1.983681e-08 | 1 |
| GO:CC | GO:0009295 | nucleoid | "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689] | 10 | 1.983681e-08 | 1 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 14 | 2.115244e-08 | 1 |
| GO:CC | GO:0042175 | nuclear outer membrane-endoplasmic reticulum membrane network | "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] | 41 | 3.596890e-08 | 1 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 16 | 4.664568e-08 | 1 |
| GO:CC | GO:0005789 | endoplasmic reticulum membrane | "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] | 39 | 2.628657e-07 | 1 |
| GO:CC | GO:0098827 | endoplasmic reticulum subcompartment | "A distinct region of the endoplasmic reticulum." [GOC:dos] | 39 | 3.018773e-07 | 1 |
| GO:CC | GO:0030659 | cytoplasmic vesicle membrane | "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] | 39 | 4.060899e-07 | 1 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 36 | 5.198132e-07 | 1 |
| GO:CC | GO:0012506 | vesicle membrane | "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] | 39 | 6.214949e-07 | 1 |
| GO:CC | GO:0031984 | organelle subcompartment | "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] | 44 | 6.668289e-07 | 1 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 31 | 3.115417e-06 | 1 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 18 | 4.206604e-06 | 1 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 18 | 5.334719e-06 | 1 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 18 | 5.591335e-06 | 1 |
| GO:CC | GO:0045259 | proton-transporting ATP synthase complex | "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [ISBN:0198547684, ISBN:0716743663] | 6 | 5.620018e-06 | 1 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 55 | 7.218257e-06 | 1 |
| GO:CC | GO:0034663 | endoplasmic reticulum chaperone complex | "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] | 5 | 2.132113e-05 | 1 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 109 | 2.747353e-05 | 1 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 109 | 2.747353e-05 | 1 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 109 | 2.747353e-05 | 1 |
| GO:CC | GO:0048471 | perinuclear region of cytoplasm | "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] | 26 | 3.792099e-05 | 1 |
| GO:CC | GO:0031968 | organelle outer membrane | "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] | 15 | 4.224101e-05 | 1 |
| GO:CC | GO:0019867 | outer membrane | "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] | 15 | 4.670823e-05 | 1 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 19 | 5.610468e-05 | 1 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 19 | 8.021465e-05 | 1 |
| GO:CC | GO:0016469 | proton-transporting two-sector ATPase complex | "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483] | 7 | 3.025500e-04 | 1 |
| GO:CC | GO:0005741 | mitochondrial outer membrane | "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] | 13 | 3.596878e-04 | 1 |
| GO:CC | GO:0005790 | smooth endoplasmic reticulum | "The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732] | 6 | 5.258621e-04 | 1 |
| GO:CC | GO:0045121 | membrane raft | "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567] | 14 | 1.263473e-03 | 1 |
| GO:CC | GO:0098857 | membrane microdomain | "A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it." [PMID:20044567, PMID:26253820] | 14 | 1.366272e-03 | 1 |
| GO:CC | GO:0071682 | endocytic vesicle lumen | "The volume enclosed by the membrane of an endocytic vesicle." [GOC:pde] | 5 | 1.400687e-03 | 1 |
| GO:CC | GO:0005768 | endosome | "A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] | 29 | 1.505661e-03 | 1 |
| GO:CC | GO:0098576 | lumenal side of membrane | "Any side (leaflet) of a membrane that faces the lumen of an organelle." [GOC:dos] | 6 | 1.653251e-03 | 1 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 37 | 4.733384e-03 | 1 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 25 | 4.973255e-03 | 1 |
| GO:CC | GO:0010008 | endosome membrane | "The lipid bilayer surrounding an endosome." [GOC:mah] | 19 | 5.525397e-03 | 1 |
| GO:CC | GO:0005769 | early endosome | "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] | 16 | 6.959696e-03 | 1 |
| GO:CC | GO:0098798 | mitochondrial protein-containing complex | "A protein complex that is part of a mitochondrion." [GOC:dos] | 10 | 9.964658e-03 | 1 |
| GO:CC | GO:0030133 | transport vesicle | "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157] | 16 | 1.047579e-02 | 1 |
| GO:CC | GO:0005794 | Golgi apparatus | "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732] | 36 | 1.048532e-02 | 1 |
| GO:CC | GO:0030135 | coated vesicle | "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] | 13 | 1.374705e-02 | 1 |
| GO:CC | GO:0005766 | primary lysosome | "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] | 9 | 1.580899e-02 | 1 |
| GO:CC | GO:0042582 | azurophil granule | "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule] | 9 | 1.580899e-02 | 1 |
| GO:CC | GO:0030662 | coated vesicle membrane | "The lipid bilayer surrounding a coated vesicle." [GOC:mah] | 10 | 2.119841e-02 | 1 |
| GO:CC | GO:0030658 | transport vesicle membrane | "The lipid bilayer surrounding a transport vesicle." [GOC:mah] | 11 | 3.196585e-02 | 1 |
| GO:CC | GO:0030117 | membrane coat | "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] | 7 | 3.359381e-02 | 1 |
| GO:CC | GO:0048475 | coated membrane | "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jid] | 7 | 3.359381e-02 | 1 |
| GO:CC | GO:0042824 | MHC class I peptide loading complex | "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934] | 3 | 3.626992e-02 | 1 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 88 | 3.890146e-02 | 1 |
| GO:CC | GO:0098803 | respiratory chain complex | "Any protein complex that is part of a respiratory chain." [GOC:dos] | 7 | 4.057735e-02 | 1 |
| GO:CC | GO:0098575 | lumenal side of lysosomal membrane | "The side (leaflet) of the lysosomal membrane that faces the lumen." [GOC:dos] | 2 | 4.338320e-02 | 1 |
| GO:CC | GO:0035632 | mitochondrial prohibitin complex | "A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death." [GOC:kmv, PMID:12237468, PMID:21164222] | 2 | 4.338320e-02 | 1 |
| GO:CC | GO:1905202 | methylcrotonoyl-CoA carboxylase complex | "A protein complex capable of methylcrotonoyl-CoA carboxylase activity. In mammals, it is a mitochondrial complex comprising a dodecamer of 6 alpha and 6 beta subunits: MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation; MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:bf, GOC:hjd, GOC:PARL, PMID:15868465, PMID:17360195, PMID:22158123, PMID:22869039] | 2 | 4.338320e-02 | 1 |
| GO:CC | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730] | 8 | 4.518358e-02 | 1 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 66 | 2.275346e-21 | 1 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 61 | 1.291673e-19 | 1 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 65 | 3.488973e-19 | 1 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 54 | 1.396402e-17 | 1 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 58 | 2.763126e-17 | 1 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 56 | 4.394584e-17 | 1 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 57 | 6.802638e-17 | 1 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 54 | 2.212004e-16 | 1 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 47 | 2.278389e-15 | 1 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 49 | 2.660945e-15 | 1 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 55 | 4.316838e-15 | 1 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 49 | 1.130786e-14 | 1 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 145 | 1.280903e-14 | 1 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 145 | 1.851625e-13 | 1 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 51 | 2.180171e-13 | 1 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 49 | 3.651845e-13 | 1 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 151 | 7.125960e-13 | 1 |
| HPA | HPA:0530000 | Spleen | Spleen | 154 | 8.872411e-13 | 1 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 43 | 1.601287e-12 | 1 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 69 | 2.186156e-12 | 1 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 43 | 2.786966e-12 | 1 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 45 | 4.547594e-12 | 1 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 144 | 5.062397e-12 | 1 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 159 | 6.308660e-12 | 1 |
| HPA | HPA:0271142 | Kidney; proximal tubules (cell body)[≥Medium] | Kidney; proximal tubules (cell body)[≥Medium] | 39 | 2.159491e-11 | 1 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 164 | 3.875898e-11 | 1 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 45 | 3.938509e-11 | 1 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 41 | 4.085736e-11 | 1 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 154 | 5.838839e-11 | 1 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 133 | 6.824657e-11 | 1 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 41 | 1.391869e-10 | 1 |
| HPA | HPA:0271122 | Kidney; collecting ducts[≥Medium] | Kidney; collecting ducts[≥Medium] | 34 | 1.629557e-10 | 1 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 164 | 1.900807e-10 | 1 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 164 | 1.900807e-10 | 1 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 163 | 1.955060e-10 | 1 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 134 | 2.041593e-10 | 1 |
| HPA | HPA:0291161 | Liver; cholangiocytes[≥Low] | Liver; cholangiocytes[≥Low] | 117 | 2.215754e-10 | 1 |
| HPA | HPA:0300000 | Lung | Lung | 170 | 2.334783e-10 | 1 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 164 | 2.563645e-10 | 1 |
| HPA | HPA:0630000 | Cervix | Cervix | 164 | 2.848134e-10 | 1 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 117 | 3.471018e-10 | 1 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 42 | 3.653739e-10 | 1 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 161 | 4.013421e-10 | 1 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 170 | 4.178061e-10 | 1 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 57 | 4.187854e-10 | 1 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 42 | 5.052822e-10 | 1 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 165 | 5.216657e-10 | 1 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 123 | 5.508086e-10 | 1 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 158 | 5.556712e-10 | 1 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 154 | 5.912469e-10 | 1 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 154 | 5.912469e-10 | 1 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 150 | 6.157147e-10 | 1 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 165 | 7.767246e-10 | 1 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 31 | 8.021294e-10 | 1 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 132 | 8.935148e-10 | 1 |
| HPA | HPA:0271133 | Kidney; distal tubules[High] | Kidney; distal tubules[High] | 27 | 9.844157e-10 | 1 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 161 | 1.054587e-09 | 1 |
| HPA | HPA:0290000 | Liver | Liver | 154 | 1.136504e-09 | 1 |
| HPA | HPA:0271132 | Kidney; distal tubules[≥Medium] | Kidney; distal tubules[≥Medium] | 36 | 1.171736e-09 | 1 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 40 | 1.682423e-09 | 1 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 168 | 1.883109e-09 | 1 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 168 | 1.883109e-09 | 1 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 37 | 1.887625e-09 | 1 |
| HPA | HPA:0050000 | Breast | Breast | 166 | 1.893140e-09 | 1 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 161 | 2.012592e-09 | 1 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 159 | 2.095890e-09 | 1 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 159 | 2.095890e-09 | 1 |
| HPA | HPA:0030000 | Appendix | Appendix | 174 | 2.467529e-09 | 1 |
| HPA | HPA:0570733 | Testis; Leydig cells[High] | Testis; Leydig cells[High] | 69 | 2.688363e-09 | 1 |
| HPA | HPA:0380000 | Placenta | Placenta | 170 | 2.753415e-09 | 1 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 32 | 2.887538e-09 | 1 |
| HPA | HPA:0271141 | Kidney; proximal tubules (cell body)[≥Low] | Kidney; proximal tubules (cell body)[≥Low] | 41 | 3.171996e-09 | 1 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 152 | 3.398535e-09 | 1 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 36 | 3.457760e-09 | 1 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 167 | 3.744456e-09 | 1 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 167 | 3.744456e-09 | 1 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 169 | 4.755761e-09 | 1 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 173 | 4.855213e-09 | 1 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 32 | 5.424952e-09 | 1 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 117 | 6.676156e-09 | 1 |
| HPA | HPA:0340000 | Ovary | Ovary | 139 | 7.471888e-09 | 1 |
| HPA | HPA:0271143 | Kidney; proximal tubules (cell body)[High] | Kidney; proximal tubules (cell body)[High] | 25 | 7.727855e-09 | 1 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 165 | 8.140823e-09 | 1 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 164 | 8.567711e-09 | 1 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 164 | 8.567711e-09 | 1 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 152 | 8.747413e-09 | 1 |
| HPA | HPA:0271121 | Kidney; collecting ducts[≥Low] | Kidney; collecting ducts[≥Low] | 36 | 1.065982e-08 | 1 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 161 | 1.548792e-08 | 1 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 137 | 1.950789e-08 | 1 |
| HPA | HPA:0390000 | Prostate | Prostate | 157 | 1.980959e-08 | 1 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 157 | 1.980959e-08 | 1 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 159 | 2.406446e-08 | 1 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 159 | 2.406446e-08 | 1 |
| HPA | HPA:0400000 | Rectum | Rectum | 174 | 2.651532e-08 | 1 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 170 | 3.203621e-08 | 1 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 170 | 3.203621e-08 | 1 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 123 | 3.577390e-08 | 1 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 77 | 4.210217e-08 | 1 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 147 | 5.353872e-08 | 1 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 103 | 5.855656e-08 | 1 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 155 | 6.734558e-08 | 1 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 146 | 6.856322e-08 | 1 |
| HPA | HPA:0080000 | Caudate | Caudate | 160 | 7.024454e-08 | 1 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 34 | 7.553498e-08 | 1 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 132 | 8.023057e-08 | 1 |
| HPA | HPA:0271123 | Kidney; collecting ducts[High] | Kidney; collecting ducts[High] | 23 | 9.307307e-08 | 1 |
| HPA | HPA:0270000 | Kidney | Kidney | 176 | 1.207761e-07 | 1 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 135 | 1.280408e-07 | 1 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 127 | 1.431048e-07 | 1 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 163 | 1.806840e-07 | 1 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 115 | 1.821970e-07 | 1 |
| HPA | HPA:0461451 | Skin 1; hair follicles[≥Low] | Skin 1; hair follicles[≥Low] | 26 | 2.658265e-07 | 1 |
| HPA | HPA:0271131 | Kidney; distal tubules[≥Low] | Kidney; distal tubules[≥Low] | 37 | 2.741652e-07 | 1 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 138 | 2.758537e-07 | 1 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 129 | 2.854587e-07 | 1 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 154 | 3.360418e-07 | 1 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 168 | 3.523293e-07 | 1 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 168 | 3.523293e-07 | 1 |
| HPA | HPA:0290401 | Liver; hepatocytes[≥Low] | Liver; hepatocytes[≥Low] | 140 | 3.968452e-07 | 1 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 139 | 4.431354e-07 | 1 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 131 | 4.495602e-07 | 1 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 81 | 4.945038e-07 | 1 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 167 | 5.161165e-07 | 1 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 167 | 5.161165e-07 | 1 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 114 | 5.205430e-07 | 1 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 143 | 5.377416e-07 | 1 |
| HPA | HPA:0461481 | Skin 1; sebaceous glands[≥Low] | Skin 1; sebaceous glands[≥Low] | 19 | 5.692400e-07 | 1 |
| HPA | HPA:0570802 | Testis; sertoli cells[≥Medium] | Testis; sertoli cells[≥Medium] | 66 | 6.446884e-07 | 1 |
| HPA | HPA:0481302 | Small intestine; enterocytes[≥Medium] | Small intestine; enterocytes[≥Medium] | 28 | 6.762895e-07 | 1 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 25 | 6.913745e-07 | 1 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 151 | 7.281126e-07 | 1 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 151 | 7.281126e-07 | 1 |
| HPA | HPA:0100211 | Cerebral cortex; neuropil[≥Low] | Cerebral cortex; neuropil[≥Low] | 127 | 7.633975e-07 | 1 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 164 | 7.859127e-07 | 1 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 173 | 8.148387e-07 | 1 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 26 | 8.222178e-07 | 1 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 164 | 8.733216e-07 | 1 |
| HPA | HPA:0461482 | Skin 1; sebaceous glands[≥Medium] | Skin 1; sebaceous glands[≥Medium] | 17 | 1.050037e-06 | 1 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 164 | 1.127087e-06 | 1 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 26 | 1.198905e-06 | 1 |
| HPA | HPA:0290402 | Liver; hepatocytes[≥Medium] | Liver; hepatocytes[≥Medium] | 104 | 1.254803e-06 | 1 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 36 | 1.260332e-06 | 1 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 56 | 1.388927e-06 | 1 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 56 | 1.388927e-06 | 1 |
| HPA | HPA:0151302 | Duodenum; enterocytes[≥Medium] | Duodenum; enterocytes[≥Medium] | 27 | 1.472598e-06 | 1 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 124 | 1.531147e-06 | 1 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 127 | 1.724442e-06 | 1 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 131 | 1.991920e-06 | 1 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 32 | 2.195201e-06 | 1 |
| HPA | HPA:0271111 | Kidney; bowman's capsule[≥Low] | Kidney; bowman's capsule[≥Low] | 21 | 2.271262e-06 | 1 |
| HPA | HPA:0130000 | Colon | Colon | 175 | 2.462176e-06 | 1 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 136 | 2.479465e-06 | 1 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 69 | 2.711389e-06 | 1 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 110 | 2.996514e-06 | 1 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 169 | 3.083191e-06 | 1 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 109 | 3.422978e-06 | 1 |
| HPA | HPA:0481352 | Small intestine; paneth cells[≥Medium] | Small intestine; paneth cells[≥Medium] | 19 | 3.676999e-06 | 1 |
| HPA | HPA:0031301 | Appendix; enterocytes[≥Low] | Appendix; enterocytes[≥Low] | 28 | 3.988356e-06 | 1 |
| HPA | HPA:0151351 | Duodenum; paneth cells[≥Low] | Duodenum; paneth cells[≥Low] | 21 | 4.064415e-06 | 1 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 111 | 4.146205e-06 | 1 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 136 | 4.221155e-06 | 1 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 169 | 4.272444e-06 | 1 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 124 | 4.387958e-06 | 1 |
| HPA | HPA:0401301 | Rectum; enterocytes[≥Low] | Rectum; enterocytes[≥Low] | 29 | 4.715585e-06 | 1 |
| HPA | HPA:0291162 | Liver; cholangiocytes[≥Medium] | Liver; cholangiocytes[≥Medium] | 66 | 5.147642e-06 | 1 |
| HPA | HPA:0091001 | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Low] | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Low] | 23 | 5.749411e-06 | 1 |
| HPA | HPA:0151303 | Duodenum; enterocytes[High] | Duodenum; enterocytes[High] | 19 | 6.483853e-06 | 1 |
| HPA | HPA:0151353 | Duodenum; paneth cells[High] | Duodenum; paneth cells[High] | 16 | 8.756825e-06 | 1 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 30 | 9.501115e-06 | 1 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 106 | 1.026752e-05 | 1 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 102 | 1.039507e-05 | 1 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 129 | 1.045574e-05 | 1 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 48 | 1.128711e-05 | 1 |
| HPA | HPA:0131302 | Colon; enterocytes[≥Medium] | Colon; enterocytes[≥Medium] | 24 | 1.160980e-05 | 1 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 66 | 1.231835e-05 | 1 |
| HPA | HPA:0131301 | Colon; enterocytes[≥Low] | Colon; enterocytes[≥Low] | 28 | 1.297965e-05 | 1 |
| HPA | HPA:0030071 | Appendix; lymphoid tissue[≥Low] | Appendix; lymphoid tissue[≥Low] | 119 | 1.372138e-05 | 1 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 118 | 1.372647e-05 | 1 |
| HPA | HPA:0151301 | Duodenum; enterocytes[≥Low] | Duodenum; enterocytes[≥Low] | 29 | 1.397713e-05 | 1 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 117 | 1.647379e-05 | 1 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 113 | 1.672553e-05 | 1 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 62 | 1.752753e-05 | 1 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 16 | 1.992143e-05 | 1 |
| HPA | HPA:0151352 | Duodenum; paneth cells[≥Medium] | Duodenum; paneth cells[≥Medium] | 19 | 2.132476e-05 | 1 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 75 | 2.142211e-05 | 1 |
| HPA | HPA:0150892 | Duodenum; goblet cells[≥Medium] | Duodenum; goblet cells[≥Medium] | 22 | 2.249821e-05 | 1 |
| HPA | HPA:0271112 | Kidney; bowman's capsule[≥Medium] | Kidney; bowman's capsule[≥Medium] | 17 | 2.357897e-05 | 1 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 36 | 2.580326e-05 | 1 |
| HPA | HPA:0100212 | Cerebral cortex; neuropil[≥Medium] | Cerebral cortex; neuropil[≥Medium] | 78 | 2.866885e-05 | 1 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 24 | 2.917120e-05 | 1 |
| HPA | HPA:0480892 | Small intestine; goblet cells[≥Medium] | Small intestine; goblet cells[≥Medium] | 22 | 3.075715e-05 | 1 |
| HPA | HPA:0150893 | Duodenum; goblet cells[High] | Duodenum; goblet cells[High] | 17 | 3.134571e-05 | 1 |
| HPA | HPA:0481351 | Small intestine; paneth cells[≥Low] | Small intestine; paneth cells[≥Low] | 19 | 3.496838e-05 | 1 |
| HPA | HPA:0401292 | Rectum; endocrine cells[≥Medium] | Rectum; endocrine cells[≥Medium] | 24 | 3.680940e-05 | 1 |
| HPA | HPA:0300413 | Lung; macrophages[High] | Lung; macrophages[High] | 50 | 4.820922e-05 | 1 |
| HPA | HPA:0481301 | Small intestine; enterocytes[≥Low] | Small intestine; enterocytes[≥Low] | 29 | 4.826721e-05 | 1 |
| HPA | HPA:0400891 | Rectum; goblet cells[≥Low] | Rectum; goblet cells[≥Low] | 24 | 4.840856e-05 | 1 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 109 | 4.857277e-05 | 1 |
| HPA | HPA:0461452 | Skin 1; hair follicles[≥Medium] | Skin 1; hair follicles[≥Medium] | 20 | 4.888870e-05 | 1 |
| HPA | HPA:0031303 | Appendix; enterocytes[High] | Appendix; enterocytes[High] | 16 | 4.964362e-05 | 1 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 106 | 5.340656e-05 | 1 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 65 | 5.503910e-05 | 1 |
| HPA | HPA:0131291 | Colon; endocrine cells[≥Low] | Colon; endocrine cells[≥Low] | 25 | 5.744757e-05 | 1 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 119 | 5.954160e-05 | 1 |
| HPA | HPA:0151292 | Duodenum; endocrine cells[≥Medium] | Duodenum; endocrine cells[≥Medium] | 25 | 6.526411e-05 | 1 |
| HPA | HPA:0481303 | Small intestine; enterocytes[High] | Small intestine; enterocytes[High] | 18 | 7.058231e-05 | 1 |
| HPA | HPA:0401291 | Rectum; endocrine cells[≥Low] | Rectum; endocrine cells[≥Low] | 25 | 7.101035e-05 | 1 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 31 | 7.217056e-05 | 1 |
| HPA | HPA:0031291 | Appendix; endocrine cells[≥Low] | Appendix; endocrine cells[≥Low] | 24 | 7.226586e-05 | 1 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 79 | 7.436100e-05 | 1 |
| HPA | HPA:0461421 | Skin 1; eccrine glands[≥Low] | Skin 1; eccrine glands[≥Low] | 18 | 7.500837e-05 | 1 |
| HPA | HPA:0031302 | Appendix; enterocytes[≥Medium] | Appendix; enterocytes[≥Medium] | 22 | 8.690581e-05 | 1 |
| HPA | HPA:0091002 | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium] | Cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium] | 20 | 8.864831e-05 | 1 |
| HPA | HPA:0481353 | Small intestine; paneth cells[High] | Small intestine; paneth cells[High] | 14 | 9.119419e-05 | 1 |
| HPA | HPA:0241101 | Heart muscle; cardiomyocytes[≥Low] | Heart muscle; cardiomyocytes[≥Low] | 143 | 9.306652e-05 | 1 |
| HPA | HPA:0240000 | Heart muscle | Heart muscle | 143 | 9.306652e-05 | 1 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 28 | 9.978948e-05 | 1 |
| HPA | HPA:0481292 | Small intestine; endocrine cells[≥Medium] | Small intestine; endocrine cells[≥Medium] | 25 | 1.031440e-04 | 1 |
| HPA | HPA:0131332 | Colon; mucosal lymphoid cells[≥Medium] | Colon; mucosal lymphoid cells[≥Medium] | 22 | 1.049441e-04 | 1 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 59 | 1.134126e-04 | 1 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 140 | 1.272625e-04 | 1 |
| HPA | HPA:0131292 | Colon; endocrine cells[≥Medium] | Colon; endocrine cells[≥Medium] | 23 | 1.281986e-04 | 1 |
| HPA | HPA:0570731 | Testis; Leydig cells[≥Low] | Testis; Leydig cells[≥Low] | 155 | 1.371387e-04 | 1 |
| HPA | HPA:0030893 | Appendix; goblet cells[High] | Appendix; goblet cells[High] | 15 | 1.498234e-04 | 1 |
| HPA | HPA:0130893 | Colon; goblet cells[High] | Colon; goblet cells[High] | 16 | 1.505836e-04 | 1 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 128 | 1.696781e-04 | 1 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 128 | 1.696781e-04 | 1 |
| HPA | HPA:0480891 | Small intestine; goblet cells[≥Low] | Small intestine; goblet cells[≥Low] | 23 | 1.891696e-04 | 1 |
| HPA | HPA:0130891 | Colon; goblet cells[≥Low] | Colon; goblet cells[≥Low] | 23 | 2.059196e-04 | 1 |
| HPA | HPA:0131331 | Colon; mucosal lymphoid cells[≥Low] | Colon; mucosal lymphoid cells[≥Low] | 26 | 2.101906e-04 | 1 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 135 | 2.166788e-04 | 1 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 135 | 2.166788e-04 | 1 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 89 | 2.317979e-04 | 1 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 101 | 2.464555e-04 | 1 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 101 | 2.464555e-04 | 1 |
| HPA | HPA:0030891 | Appendix; goblet cells[≥Low] | Appendix; goblet cells[≥Low] | 22 | 2.476739e-04 | 1 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 104 | 2.888048e-04 | 1 |
| HPA | HPA:0131303 | Colon; enterocytes[High] | Colon; enterocytes[High] | 16 | 3.226529e-04 | 1 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 132 | 3.266493e-04 | 1 |
| HPA | HPA:0510652 | Soft tissue 2; fibroblasts[≥Medium] | Soft tissue 2; fibroblasts[≥Medium] | 75 | 3.287016e-04 | 1 |
| HPA | HPA:0151293 | Duodenum; endocrine cells[High] | Duodenum; endocrine cells[High] | 19 | 3.680862e-04 | 1 |
| HPA | HPA:0151291 | Duodenum; endocrine cells[≥Low] | Duodenum; endocrine cells[≥Low] | 25 | 3.726094e-04 | 1 |
| HPA | HPA:0620000 | Vagina | Vagina | 136 | 3.800703e-04 | 1 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 136 | 3.800703e-04 | 1 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 108 | 3.823543e-04 | 1 |
| HPA | HPA:0481291 | Small intestine; endocrine cells[≥Low] | Small intestine; endocrine cells[≥Low] | 25 | 3.866451e-04 | 1 |
| HPA | HPA:0381222 | Placenta; syncytiotrophoblasts - microvilli[≥Medium] | Placenta; syncytiotrophoblasts - microvilli[≥Medium] | 19 | 3.867154e-04 | 1 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 147 | 4.361530e-04 | 1 |
| HPA | HPA:0241102 | Heart muscle; cardiomyocytes[≥Medium] | Heart muscle; cardiomyocytes[≥Medium] | 108 | 4.635183e-04 | 1 |
| HPA | HPA:0570000 | Testis | Testis | 179 | 4.855443e-04 | 1 |
| HPA | HPA:0150891 | Duodenum; goblet cells[≥Low] | Duodenum; goblet cells[≥Low] | 22 | 5.521573e-04 | 1 |
| HPA | HPA:0400892 | Rectum; goblet cells[≥Medium] | Rectum; goblet cells[≥Medium] | 20 | 5.910829e-04 | 1 |
| HPA | HPA:0031293 | Appendix; endocrine cells[High] | Appendix; endocrine cells[High] | 16 | 6.193761e-04 | 1 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 154 | 6.201765e-04 | 1 |
| HPA | HPA:0030892 | Appendix; goblet cells[≥Medium] | Appendix; goblet cells[≥Medium] | 19 | 6.261587e-04 | 1 |
| HPA | HPA:0151342 | Duodenum; glands of Brunner[≥Medium] | Duodenum; glands of Brunner[≥Medium] | 15 | 6.879304e-04 | 1 |
| HPA | HPA:0401331 | Rectum; mucosal lymphoid cells[≥Low] | Rectum; mucosal lymphoid cells[≥Low] | 26 | 7.032598e-04 | 1 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 126 | 7.833417e-04 | 1 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 67 | 7.885842e-04 | 1 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 19 | 8.278491e-04 | 1 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 46 | 8.482494e-04 | 1 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 121 | 8.751148e-04 | 1 |
| HPA | HPA:0131333 | Colon; mucosal lymphoid cells[High] | Colon; mucosal lymphoid cells[High] | 13 | 8.801210e-04 | 1 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 43 | 9.023293e-04 | 1 |
| HPA | HPA:0090181 | Cerebellum; cells in granular layer[≥Low] | Cerebellum; cells in granular layer[≥Low] | 110 | 9.605785e-04 | 1 |
| HPA | HPA:0151341 | Duodenum; glands of Brunner[≥Low] | Duodenum; glands of Brunner[≥Low] | 17 | 1.059688e-03 | 1 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 93 | 1.110404e-03 | 1 |
| HPA | HPA:0060101 | Bronchus; respiratory epithelial cells[≥Low] | Bronchus; respiratory epithelial cells[≥Low] | 133 | 1.168041e-03 | 1 |
| HPA | HPA:0400893 | Rectum; goblet cells[High] | Rectum; goblet cells[High] | 15 | 1.177097e-03 | 1 |
| HPA | HPA:0461422 | Skin 1; eccrine glands[≥Medium] | Skin 1; eccrine glands[≥Medium] | 14 | 1.293668e-03 | 1 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 116 | 1.302994e-03 | 1 |
| HPA | HPA:0381221 | Placenta; syncytiotrophoblasts - microvilli[≥Low] | Placenta; syncytiotrophoblasts - microvilli[≥Low] | 20 | 1.342545e-03 | 1 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 69 | 1.614502e-03 | 1 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 117 | 1.640354e-03 | 1 |
| HPA | HPA:0090182 | Cerebellum; cells in granular layer[≥Medium] | Cerebellum; cells in granular layer[≥Medium] | 79 | 1.663701e-03 | 1 |
| HPA | HPA:0130892 | Colon; goblet cells[≥Medium] | Colon; goblet cells[≥Medium] | 19 | 1.684922e-03 | 1 |
| HPA | HPA:0031292 | Appendix; endocrine cells[≥Medium] | Appendix; endocrine cells[≥Medium] | 20 | 1.718075e-03 | 1 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 100 | 1.718370e-03 | 1 |
| HPA | HPA:0530712 | Spleen; cells in red pulp[≥Medium] | Spleen; cells in red pulp[≥Medium] | 83 | 2.030111e-03 | 1 |
| HPA | HPA:0131293 | Colon; endocrine cells[High] | Colon; endocrine cells[High] | 16 | 2.032243e-03 | 1 |
| HPA | HPA:0091072 | Cerebellum; white matter cells - cytoplasm/membrane[≥Medium] | Cerebellum; white matter cells - cytoplasm/membrane[≥Medium] | 15 | 2.066742e-03 | 1 |
| HPA | HPA:0401303 | Rectum; enterocytes[High] | Rectum; enterocytes[High] | 15 | 2.704870e-03 | 1 |
| HPA | HPA:0030431 | Appendix; germinal center cells[≥Low] | Appendix; germinal center cells[≥Low] | 17 | 2.784002e-03 | 1 |
| HPA | HPA:0380521 | Placenta; trophoblastic cells[≥Low] | Placenta; trophoblastic cells[≥Low] | 139 | 2.816185e-03 | 1 |
| HPA | HPA:0091071 | Cerebellum; white matter cells - cytoplasm/membrane[≥Low] | Cerebellum; white matter cells - cytoplasm/membrane[≥Low] | 17 | 2.914681e-03 | 1 |
| HPA | HPA:0220053 | Gallbladder; glandular cells[High] | Gallbladder; glandular cells[High] | 77 | 3.007565e-03 | 1 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 117 | 3.205533e-03 | 1 |
| HPA | HPA:0530713 | Spleen; cells in red pulp[High] | Spleen; cells in red pulp[High] | 32 | 3.394086e-03 | 1 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 73 | 3.594935e-03 | 1 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 16 | 3.669111e-03 | 1 |
| HPA | HPA:0600443 | Tonsil; non-germinal center cells[High] | Tonsil; non-germinal center cells[High] | 44 | 3.839931e-03 | 1 |
| HPA | HPA:0480893 | Small intestine; goblet cells[High] | Small intestine; goblet cells[High] | 14 | 4.161954e-03 | 1 |
| HPA | HPA:0090971 | Cerebellum; granular cells - cytoplasm/membrane[≥Low] | Cerebellum; granular cells - cytoplasm/membrane[≥Low] | 17 | 4.174440e-03 | 1 |
| HPA | HPA:0360053 | Parathyroid gland; glandular cells[High] | Parathyroid gland; glandular cells[High] | 49 | 4.227801e-03 | 1 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 17 | 4.362028e-03 | 1 |
| HPA | HPA:0401293 | Rectum; endocrine cells[High] | Rectum; endocrine cells[High] | 16 | 4.863595e-03 | 1 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 65 | 5.507227e-03 | 1 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 18 | 5.986752e-03 | 1 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 74 | 6.753776e-03 | 1 |
| HPA | HPA:0500111 | Soft tissue 1; chondrocytes[≥Low] | Soft tissue 1; chondrocytes[≥Low] | 62 | 6.863188e-03 | 1 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 46 | 8.555197e-03 | 1 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 110 | 9.804701e-03 | 1 |
| HPA | HPA:0271113 | Kidney; bowman's capsule[High] | Kidney; bowman's capsule[High] | 10 | 1.077901e-02 | 1 |
| HPA | HPA:0481293 | Small intestine; endocrine cells[High] | Small intestine; endocrine cells[High] | 16 | 1.124519e-02 | 1 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 72 | 1.258389e-02 | 1 |
| HPA | HPA:0291163 | Liver; cholangiocytes[High] | Liver; cholangiocytes[High] | 17 | 1.277747e-02 | 1 |
| HPA | HPA:0090972 | Cerebellum; granular cells - cytoplasm/membrane[≥Medium] | Cerebellum; granular cells - cytoplasm/membrane[≥Medium] | 14 | 1.281418e-02 | 1 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 41 | 1.286209e-02 | 1 |
| HPA | HPA:0400241 | Rectum; peripheral nerve/ganglion[≥Low] | Rectum; peripheral nerve/ganglion[≥Low] | 15 | 1.334746e-02 | 1 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 37 | 1.397441e-02 | 1 |
| HPA | HPA:0500112 | Soft tissue 1; chondrocytes[≥Medium] | Soft tissue 1; chondrocytes[≥Medium] | 45 | 1.607192e-02 | 1 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 15 | 1.732164e-02 | 1 |
| HPA | HPA:0381201 | Placenta; hofbauer cells[≥Low] | Placenta; hofbauer cells[≥Low] | 20 | 1.975110e-02 | 1 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 90 | 2.018443e-02 | 1 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 54 | 2.076695e-02 | 1 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 33 | 2.098625e-02 | 1 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 34 | 2.151399e-02 | 1 |
| HPA | HPA:0151343 | Duodenum; glands of Brunner[High] | Duodenum; glands of Brunner[High] | 9 | 2.248669e-02 | 1 |
| HPA | HPA:0090941 | Cerebellum; Purkinje cells - cytoplasm/membrane[≥Low] | Cerebellum; Purkinje cells - cytoplasm/membrane[≥Low] | 20 | 2.311264e-02 | 1 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 76 | 2.628310e-02 | 1 |
| HPA | HPA:0471481 | Skin 2; sebaceous glands[≥Low] | Skin 2; sebaceous glands[≥Low] | 10 | 2.798445e-02 | 1 |
| HPA | HPA:0500701 | Soft tissue 1; peripheral nerve[≥Low] | Soft tissue 1; peripheral nerve[≥Low] | 72 | 2.929263e-02 | 1 |
| HPA | HPA:0381202 | Placenta; hofbauer cells[≥Medium] | Placenta; hofbauer cells[≥Medium] | 18 | 3.193161e-02 | 1 |
| HPA | HPA:0150052 | Duodenum; glandular cells[≥Medium] | Duodenum; glandular cells[≥Medium] | 131 | 3.477564e-02 | 1 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 16 | 3.514383e-02 | 1 |
| HPA | HPA:0080123 | Caudate; glial cells[High] | Caudate; glial cells[High] | 26 | 3.709281e-02 | 1 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 51 | 4.146806e-02 | 1 |
| HPA | HPA:0030432 | Appendix; germinal center cells[≥Medium] | Appendix; germinal center cells[≥Medium] | 13 | 4.442661e-02 | 1 |
| HPA | HPA:0510701 | Soft tissue 2; peripheral nerve[≥Low] | Soft tissue 2; peripheral nerve[≥Low] | 79 | 4.664453e-02 | 1 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0044281 | small molecule metabolic process | "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] | 71 | 1.646110e-19 | 1 |
| GO:BP | GO:0072524 | pyridine-containing compound metabolic process | "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 24 | 1.047159e-16 | 1 |
| GO:BP | GO:0006753 | nucleoside phosphate metabolic process | "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] | 41 | 1.078710e-16 | 1 |
| GO:BP | GO:0072521 | purine-containing compound metabolic process | "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 38 | 3.599090e-16 | 1 |
| GO:BP | GO:0055086 | nucleobase-containing small molecule metabolic process | "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] | 41 | 4.773390e-16 | 1 |
| GO:BP | GO:0043436 | oxoacid metabolic process | "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] | 47 | 6.110793e-16 | 1 |
| GO:BP | GO:0006082 | organic acid metabolic process | "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] | 47 | 7.955966e-16 | 1 |
| GO:BP | GO:0019752 | carboxylic acid metabolic process | "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] | 46 | 1.388721e-15 | 1 |
| GO:BP | GO:0009117 | nucleotide metabolic process | "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] | 35 | 2.258131e-15 | 1 |
| GO:BP | GO:0006163 | purine nucleotide metabolic process | "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 33 | 2.303703e-15 | 1 |
| GO:BP | GO:0019362 | pyridine nucleotide metabolic process | "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] | 22 | 1.061333e-14 | 1 |
| GO:BP | GO:0046496 | nicotinamide nucleotide metabolic process | "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] | 22 | 1.061333e-14 | 1 |
| GO:BP | GO:0006091 | generation of precursor metabolites and energy | "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] | 33 | 5.515271e-14 | 1 |
| GO:BP | GO:0019637 | organophosphate metabolic process | "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] | 48 | 9.426700e-14 | 1 |
| GO:BP | GO:0032787 | monocarboxylic acid metabolic process | "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] | 36 | 3.497879e-13 | 1 |
| GO:BP | GO:0015031 | protein transport | "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 52 | 2.493666e-11 | 1 |
| GO:BP | GO:1901135 | carbohydrate derivative metabolic process | "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] | 42 | 4.961802e-11 | 1 |
| GO:BP | GO:0051234 | establishment of localization | "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] | 106 | 6.251022e-11 | 1 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] | 68 | 1.278064e-10 | 1 |
| GO:BP | GO:0006793 | phosphorus metabolic process | "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] | 68 | 1.357475e-10 | 1 |
| GO:BP | GO:0006810 | transport | "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] | 98 | 1.563712e-10 | 1 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 80 | 4.116070e-10 | 1 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 112 | 6.340287e-10 | 1 |
| GO:BP | GO:0008219 | cell death | "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] | 59 | 1.372040e-09 | 1 |
| GO:BP | GO:0045184 | establishment of protein localization | "The directed movement of a protein to a specific location." [GOC:bf] | 58 | 1.480430e-09 | 1 |
| GO:BP | GO:0046034 | ATP metabolic process | "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] | 20 | 1.850115e-09 | 1 |
| GO:BP | GO:0009150 | purine ribonucleotide metabolic process | "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 24 | 1.907210e-09 | 1 |
| GO:BP | GO:0009144 | purine nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 21 | 2.239588e-09 | 1 |
| GO:BP | GO:0012501 | programmed cell death | "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] | 58 | 4.267272e-09 | 1 |
| GO:BP | GO:0009259 | ribonucleotide metabolic process | "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 24 | 6.593226e-09 | 1 |
| GO:BP | GO:0046434 | organophosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai] | 20 | 6.991786e-09 | 1 |
| GO:BP | GO:0009141 | nucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 21 | 7.072251e-09 | 1 |
| GO:BP | GO:0019693 | ribose phosphate metabolic process | "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 24 | 1.034555e-08 | 1 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 70 | 1.053853e-08 | 1 |
| GO:BP | GO:0009205 | purine ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 20 | 1.171834e-08 | 1 |
| GO:BP | GO:0071705 | nitrogen compound transport | "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] | 56 | 1.258291e-08 | 1 |
| GO:BP | GO:0006915 | apoptotic process | "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] | 56 | 1.258291e-08 | 1 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 70 | 1.291393e-08 | 1 |
| GO:BP | GO:0006090 | pyruvate metabolic process | "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] | 15 | 1.298865e-08 | 1 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 83 | 1.517258e-08 | 1 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 46 | 1.722788e-08 | 1 |
| GO:BP | GO:0009199 | ribonucleoside triphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 20 | 1.931733e-08 | 1 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 67 | 2.956630e-08 | 1 |
| GO:BP | GO:0072523 | purine-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 16 | 2.971196e-08 | 1 |
| GO:BP | GO:0006886 | intracellular protein transport | "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] | 31 | 4.354707e-08 | 1 |
| GO:BP | GO:1901292 | nucleoside phosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie] | 17 | 4.415876e-08 | 1 |
| GO:BP | GO:0009166 | nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] | 16 | 5.835741e-08 | 1 |
| GO:BP | GO:0006195 | purine nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 15 | 6.195963e-08 | 1 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 53 | 6.632724e-08 | 1 |
| GO:BP | GO:0042981 | regulation of apoptotic process | "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 46 | 1.179892e-07 | 1 |
| GO:BP | GO:0072526 | pyridine-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] | 13 | 1.741172e-07 | 1 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] | 58 | 2.224695e-07 | 1 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 55 | 2.228834e-07 | 1 |
| GO:BP | GO:0009154 | purine ribonucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 14 | 2.916760e-07 | 1 |
| GO:BP | GO:0043067 | regulation of programmed cell death | "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 46 | 3.149910e-07 | 1 |
| GO:BP | GO:0042221 | response to chemical | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] | 83 | 4.659688e-07 | 1 |
| GO:BP | GO:0009261 | ribonucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 14 | 5.940421e-07 | 1 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 17 | 6.320131e-07 | 1 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] | 33 | 1.009709e-06 | 1 |
| GO:BP | GO:0006096 | glycolytic process | "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] | 12 | 1.040628e-06 | 1 |
| GO:BP | GO:0046032 | ADP catabolic process | "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators] | 12 | 1.331356e-06 | 1 |
| GO:BP | GO:0019364 | pyridine nucleotide catabolic process | "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw] | 12 | 1.693527e-06 | 1 |
| GO:BP | GO:0009137 | purine nucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 12 | 1.906061e-06 | 1 |
| GO:BP | GO:0009181 | purine ribonucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 12 | 1.906061e-06 | 1 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] | 33 | 2.431396e-06 | 1 |
| GO:BP | GO:0009185 | ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 13 | 2.522752e-06 | 1 |
| GO:BP | GO:0009191 | ribonucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 12 | 2.695902e-06 | 1 |
| GO:BP | GO:0046031 | ADP metabolic process | "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators] | 12 | 3.018404e-06 | 1 |
| GO:BP | GO:0044283 | small molecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] | 26 | 3.834376e-06 | 1 |
| GO:BP | GO:0009134 | nucleoside diphosphate catabolic process | "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 12 | 4.205382e-06 | 1 |
| GO:BP | GO:0009132 | nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 13 | 4.931738e-06 | 1 |
| GO:BP | GO:0006734 | NADH metabolic process | "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] | 8 | 4.960238e-06 | 1 |
| GO:BP | GO:1901136 | carbohydrate derivative catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie] | 17 | 7.323062e-06 | 1 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 46 | 8.505732e-06 | 1 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 27 | 8.652153e-06 | 1 |
| GO:BP | GO:0009179 | purine ribonucleoside diphosphate metabolic process | "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 12 | 1.070256e-05 | 1 |
| GO:BP | GO:0009135 | purine nucleoside diphosphate metabolic process | "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 12 | 1.070256e-05 | 1 |
| GO:BP | GO:0006950 | response to stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 80 | 1.120841e-05 | 1 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 75 | 1.205534e-05 | 1 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 24 | 1.239707e-05 | 1 |
| GO:BP | GO:0016192 | vesicle-mediated transport | "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] | 44 | 1.823884e-05 | 1 |
| GO:BP | GO:0005975 | carbohydrate metabolic process | "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] | 24 | 2.676649e-05 | 1 |
| GO:BP | GO:0050896 | response to stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] | 140 | 4.383076e-05 | 1 |
| GO:BP | GO:0061718 | glucose catabolic process to pyruvate | "The chemical reactions and pathways resulting in the breakdown of glucose, with the production of pyruvate." [GOC:dph] | 6 | 5.134184e-05 | 1 |
| GO:BP | GO:0061621 | canonical glycolysis | "The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479] | 6 | 5.134184e-05 | 1 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] | 16 | 9.974118e-05 | 1 |
| GO:BP | GO:0061620 | glycolytic process through glucose-6-phosphate | "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479] | 6 | 1.052516e-04 | 1 |
| GO:BP | GO:0016052 | carbohydrate catabolic process | "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] | 13 | 1.182361e-04 | 1 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 87 | 1.690457e-04 | 1 |
| GO:BP | GO:0006979 | response to oxidative stress | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] | 19 | 1.860502e-04 | 1 |
| GO:BP | GO:0098869 | cellular oxidant detoxification | "Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide." [GOC:dos, GOC:vw] | 10 | 1.924202e-04 | 1 |
| GO:BP | GO:0034975 | protein folding in endoplasmic reticulum | "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw] | 5 | 2.145643e-04 | 1 |
| GO:BP | GO:0005996 | monosaccharide metabolic process | "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732] | 15 | 2.241710e-04 | 1 |
| GO:BP | GO:1901137 | carbohydrate derivative biosynthetic process | "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie] | 23 | 3.293234e-04 | 1 |
| GO:BP | GO:0061615 | glycolytic process through fructose-6-phosphate | "The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479] | 6 | 3.523502e-04 | 1 |
| GO:BP | GO:1902600 | proton transmembrane transport | "The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] | 13 | 3.542517e-04 | 1 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] | 47 | 3.577291e-04 | 1 |
| GO:BP | GO:0019318 | hexose metabolic process | "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] | 14 | 4.049911e-04 | 1 |
| GO:BP | GO:0097237 | cellular response to toxic substance | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:pr] | 11 | 4.405395e-04 | 1 |
| GO:BP | GO:0015980 | energy derivation by oxidation of organic compounds | "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] | 17 | 5.381495e-04 | 1 |
| GO:BP | GO:0006007 | glucose catabolic process | "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] | 6 | 5.917752e-04 | 1 |
| GO:BP | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] | 11 | 5.964914e-04 | 1 |
| GO:BP | GO:0000302 | response to reactive oxygen species | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] | 13 | 6.045738e-04 | 1 |
| GO:BP | GO:0009060 | aerobic respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] | 13 | 6.045738e-04 | 1 |
| GO:BP | GO:0007005 | mitochondrion organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] | 19 | 6.769030e-04 | 1 |
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 27 | 7.713695e-04 | 1 |
| GO:BP | GO:1901293 | nucleoside phosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie] | 16 | 7.791653e-04 | 1 |
| GO:BP | GO:0045333 | cellular respiration | "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732] | 14 | 9.299394e-04 | 1 |
| GO:BP | GO:0051156 | glucose 6-phosphate metabolic process | "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] | 6 | 1.187928e-03 | 1 |
| GO:BP | GO:0019320 | hexose catabolic process | "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] | 7 | 1.224934e-03 | 1 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 44 | 1.426485e-03 | 1 |
| GO:BP | GO:0044282 | small molecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw] | 17 | 1.481648e-03 | 1 |
| GO:BP | GO:0009636 | response to toxic substance | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr] | 14 | 1.512026e-03 | 1 |
| GO:BP | GO:0042592 | homeostatic process | "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172] | 42 | 1.603893e-03 | 1 |
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 19 | 1.623598e-03 | 1 |
| GO:BP | GO:0006006 | glucose metabolic process | "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] | 12 | 1.765899e-03 | 1 |
| GO:BP | GO:1990748 | cellular detoxification | "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw] | 10 | 1.835470e-03 | 1 |
| GO:BP | GO:0072522 | purine-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] | 14 | 1.911057e-03 | 1 |
| GO:BP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 60 | 2.091029e-03 | 1 |
| GO:BP | GO:0046365 | monosaccharide catabolic process | "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] | 7 | 2.202561e-03 | 1 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 33 | 2.231932e-03 | 1 |
| GO:BP | GO:0042542 | response to hydrogen peroxide | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl] | 9 | 2.494413e-03 | 1 |
| GO:BP | GO:0090407 | organophosphate biosynthetic process | "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg] | 22 | 2.586760e-03 | 1 |
| GO:BP | GO:0009165 | nucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] | 13 | 2.966253e-03 | 1 |
| GO:BP | GO:0006790 | sulfur compound metabolic process | "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] | 15 | 3.180718e-03 | 1 |
| GO:BP | GO:0009152 | purine ribonucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 11 | 3.210899e-03 | 1 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 24 | 3.213048e-03 | 1 |
| GO:BP | GO:0072593 | reactive oxygen species metabolic process | "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [GOC:mah] | 13 | 3.268031e-03 | 1 |
| GO:BP | GO:0006754 | ATP biosynthetic process | "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732] | 9 | 3.495771e-03 | 1 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] | 15 | 3.730793e-03 | 1 |
| GO:BP | GO:0048193 | Golgi vesicle transport | "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] | 15 | 3.730793e-03 | 1 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 20 | 3.734707e-03 | 1 |
| GO:BP | GO:0098761 | cellular response to interleukin-7 | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah] | 5 | 3.910379e-03 | 1 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] | 32 | 3.930885e-03 | 1 |
| GO:BP | GO:0051716 | cellular response to stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] | 115 | 4.137356e-03 | 1 |
| GO:BP | GO:0009725 | response to hormone | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] | 27 | 4.716027e-03 | 1 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 27 | 4.716027e-03 | 1 |
| GO:BP | GO:0016236 | macroautophagy | "The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339] | 16 | 5.031723e-03 | 1 |
| GO:BP | GO:1901698 | response to nitrogen compound | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] | 30 | 5.083567e-03 | 1 |
| GO:BP | GO:0098760 | response to interleukin-7 | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah] | 5 | 5.086745e-03 | 1 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] | 41 | 5.680465e-03 | 1 |
| GO:BP | GO:0051345 | positive regulation of hydrolase activity | "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] | 12 | 5.771736e-03 | 1 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] | 21 | 6.748888e-03 | 1 |
| GO:BP | GO:0034599 | cellular response to oxidative stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] | 13 | 6.846749e-03 | 1 |
| GO:BP | GO:0009260 | ribonucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 11 | 7.641227e-03 | 1 |
| GO:BP | GO:0141124 | intracellular signaling cassette | "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] | 43 | 7.801875e-03 | 1 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 58 | 8.176816e-03 | 1 |
| GO:BP | GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 9 | 8.212123e-03 | 1 |
| GO:BP | GO:0009145 | purine nucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 9 | 8.832183e-03 | 1 |
| GO:BP | GO:0009306 | protein secretion | "The controlled release of proteins from a cell." [GOC:ai] | 16 | 9.037425e-03 | 1 |
| GO:BP | GO:0030043 | actin filament fragmentation | "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins." [GOC:mah, ISBN:0815316194] | 3 | 9.858605e-03 | 1 |
| GO:BP | GO:0034614 | cellular response to reactive oxygen species | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah] | 10 | 9.969891e-03 | 1 |
| GO:BP | GO:0035592 | establishment of protein localization to extracellular region | "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF] | 16 | 9.985651e-03 | 1 |
| GO:BP | GO:0051049 | regulation of transport | "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 38 | 9.995846e-03 | 1 |
| GO:BP | GO:0006739 | NADP metabolic process | "The chemical reactions and pathways involving nicotinamide adenine dinucleotide phosphate (NADP+), a coenzyme that interconverts with its reduced form, NADPH, in many redox and biosynthetic reactions." [GOC:mah] | 6 | 1.007705e-02 | 1 |
| GO:BP | GO:0019725 | cellular homeostasis | "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] | 25 | 1.034655e-02 | 1 |
| GO:BP | GO:0046390 | ribose phosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] | 11 | 1.111396e-02 | 1 |
| GO:BP | GO:0098754 | detoxification | "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:dos] | 10 | 1.124582e-02 | 1 |
| GO:BP | GO:0071692 | protein localization to extracellular region | "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah] | 16 | 1.215372e-02 | 1 |
| GO:BP | GO:0019682 | glyceraldehyde-3-phosphate metabolic process | "The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai, ISBN:0198506732] | 4 | 1.239501e-02 | 1 |
| GO:BP | GO:0009201 | ribonucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 9 | 1.257175e-02 | 1 |
| GO:BP | GO:0046364 | monosaccharide biosynthetic process | "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] | 8 | 1.359411e-02 | 1 |
| GO:BP | GO:0070201 | regulation of establishment of protein localization | "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] | 19 | 1.494224e-02 | 1 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 44 | 1.499835e-02 | 1 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] | 33 | 1.600648e-02 | 1 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [GOC:ai] | 15 | 1.611967e-02 | 1 |
| GO:BP | GO:0006629 | lipid metabolic process | "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] | 34 | 1.682845e-02 | 1 |
| GO:BP | GO:0006164 | purine nucleotide biosynthetic process | "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] | 11 | 1.843407e-02 | 1 |
| GO:BP | GO:1903829 | positive regulation of protein localization | "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 18 | 2.012289e-02 | 1 |
| GO:BP | GO:0009142 | nucleoside triphosphate biosynthetic process | "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] | 9 | 2.135918e-02 | 1 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 26 | 2.148606e-02 | 1 |
| GO:BP | GO:0062197 | cellular response to chemical stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] | 14 | 2.169552e-02 | 1 |
| GO:BP | GO:0043603 | amide metabolic process | "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators] | 17 | 2.268511e-02 | 1 |
| GO:BP | GO:0046394 | carboxylic acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] | 14 | 2.411646e-02 | 1 |
| GO:BP | GO:0043648 | dicarboxylic acid metabolic process | "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] | 8 | 2.540811e-02 | 1 |
| GO:BP | GO:0016053 | organic acid biosynthetic process | "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] | 14 | 2.677321e-02 | 1 |
| GO:BP | GO:0071453 | cellular response to oxygen levels | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah] | 10 | 2.762060e-02 | 1 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 7 | 3.176848e-02 | 1 |
| GO:BP | GO:0023057 | negative regulation of signaling | "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 34 | 3.225644e-02 | 1 |
| GO:BP | GO:0010648 | negative regulation of cell communication | "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 34 | 3.272407e-02 | 1 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 27 | 3.505132e-02 | 1 |
| GO:BP | GO:0042744 | hydrogen peroxide catabolic process | "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl] | 5 | 3.884942e-02 | 1 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] | 15 | 3.968828e-02 | 1 |
| GO:BP | GO:0023051 | regulation of signaling | "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] | 63 | 4.116621e-02 | 1 |
| GO:BP | GO:0009966 | regulation of signal transduction | "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] | 57 | 4.119398e-02 | 1 |
| GO:BP | GO:0009628 | response to abiotic stimulus | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] | 29 | 4.262530e-02 | 1 |
| GO:BP | GO:0010646 | regulation of cell communication | "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] | 63 | 4.425106e-02 | 1 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators] | 20 | 4.847509e-02 | 1 |
| GO:BP | GO:0002397 | MHC class I protein complex assembly | "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] | 3 | 4.849848e-02 | 1 |
| GO:BP | GO:0002502 | peptide antigen assembly with MHC class I protein complex | "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] | 3 | 4.849848e-02 | 1 |
| GO:BP | GO:0009052 | pentose-phosphate shunt, non-oxidative branch | "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY] | 3 | 4.849848e-02 | 1 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] | 20 | 4.956285e-02 | 1 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 147 | 2.130483e-17 | 1 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 82 | 2.808290e-16 | 1 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 83 | 1.468335e-15 | 1 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 224 | 1.709089e-15 | 1 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 75 | 1.204460e-13 | 1 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 74 | 2.862962e-13 | 1 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 70 | 1.090376e-12 | 1 |
| GO:MF | GO:0016491 | oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-] | 37 | 4.520569e-11 | 1 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 130 | 9.628927e-11 | 1 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 64 | 3.150959e-10 | 1 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 70 | 4.978331e-10 | 1 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 63 | 7.176536e-10 | 1 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 53 | 2.403998e-09 | 1 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 59 | 2.079249e-08 | 1 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 120 | 8.619776e-08 | 1 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 13 | 2.666740e-07 | 1 |
| GO:MF | GO:0016835 | carbon-oxygen lyase activity | "Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-] | 11 | 5.443935e-07 | 1 |
| GO:MF | GO:0016836 | hydro-lyase activity | "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-] | 10 | 5.505675e-07 | 1 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 46 | 1.203625e-06 | 1 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 25 | 4.104217e-06 | 1 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 44 | 4.756085e-06 | 1 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 19 | 5.659745e-06 | 1 |
| GO:MF | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism | "Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722] | 6 | 1.514550e-05 | 1 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 54 | 1.839189e-05 | 1 |
| GO:MF | GO:0016209 | antioxidant activity | "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] | 10 | 2.109541e-05 | 1 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 17 | 4.521770e-05 | 1 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 51 | 9.671523e-05 | 1 |
| GO:MF | GO:0016860 | intramolecular oxidoreductase activity | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators] | 8 | 1.019971e-04 | 1 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 17 | 1.020011e-04 | 1 |
| GO:MF | GO:0004601 | peroxidase activity | "Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators] | 8 | 1.174768e-04 | 1 |
| GO:MF | GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor | "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [EC:1.11.-.-] | 8 | 1.545483e-04 | 1 |
| GO:MF | GO:0016829 | lyase activity | "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-] | 14 | 1.581634e-04 | 1 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 35 | 1.706751e-04 | 1 |
| GO:MF | GO:0015252 | proton channel activity | "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] | 6 | 2.790168e-04 | 1 |
| GO:MF | GO:0016874 | ligase activity | "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-] | 12 | 4.163566e-04 | 1 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 8 | 4.711556e-04 | 1 |
| GO:MF | GO:0051920 | peroxiredoxin activity | "Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH." [RHEA:10008] | 4 | 4.811680e-04 | 1 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 36 | 4.925547e-04 | 1 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 35 | 5.265528e-04 | 1 |
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 6 | 5.297111e-04 | 1 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 35 | 5.361455e-04 | 1 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 35 | 5.361455e-04 | 1 |
| GO:MF | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-] | 10 | 7.427855e-04 | 1 |
| GO:MF | GO:0015078 | proton transmembrane transporter activity | "Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai] | 12 | 7.457272e-04 | 1 |
| GO:MF | GO:0015035 | protein-disulfide reductase activity | "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385] | 6 | 9.399400e-04 | 1 |
| GO:MF | GO:0008289 | lipid binding | "Binding to a lipid." [GOC:ai] | 27 | 9.769206e-04 | 1 |
| GO:MF | GO:0043531 | ADP binding | "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl] | 7 | 1.012227e-03 | 1 |
| GO:MF | GO:0051287 | NAD binding | "Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] | 7 | 1.012227e-03 | 1 |
| GO:MF | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors | "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [EC:1.8.-.-, GOC:ai] | 7 | 1.306704e-03 | 1 |
| GO:MF | GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] | 10 | 1.501051e-03 | 1 |
| GO:MF | GO:0015036 | disulfide oxidoreductase activity | "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [GOC:curators] | 6 | 2.531647e-03 | 1 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 230 | 2.953490e-03 | 1 |
| GO:MF | GO:0046625 | sphingolipid binding | "Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732] | 5 | 5.312250e-03 | 1 |
| GO:MF | GO:0051087 | protein-folding chaperone binding | "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443] | 9 | 1.078552e-02 | 1 |
| GO:MF | GO:0003925 | G protein activity | "A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015] | 6 | 1.196118e-02 | 1 |
| GO:MF | GO:0140824 | thioredoxin-dependent peroxiredoxin activity | "Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O." [PMID:12707274, PMID:19820102, RHEA:62620] | 3 | 1.217738e-02 | 1 |
| GO:MF | GO:0016421 | CoA carboxylase activity | "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah] | 3 | 1.217738e-02 | 1 |
| GO:MF | GO:0008379 | thioredoxin peroxidase activity | "Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O." [RHEA:63528] | 3 | 1.217738e-02 | 1 |
| GO:MF | GO:0033218 | amide binding | "Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah] | 12 | 1.223048e-02 | 1 |
| GO:MF | GO:0048029 | monosaccharide binding | "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid] | 7 | 1.248431e-02 | 1 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 27 | 1.585450e-02 | 1 |
| GO:MF | GO:0042288 | MHC class I protein binding | "Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] | 4 | 1.920343e-02 | 1 |
| GO:MF | GO:0016885 | ligase activity, forming carbon-carbon bonds | "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4.-.-] | 3 | 2.112832e-02 | 1 |
| GO:MF | GO:0003756 | protein disulfide isomerase activity | "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function] | 4 | 2.410431e-02 | 1 |
| GO:MF | GO:0016864 | intramolecular oxidoreductase activity, transposing S-S bonds | "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4.-, GOC:mah] | 4 | 2.410431e-02 | 1 |
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 16 | 2.469487e-02 | 1 |
| GO:MF | GO:0019842 | vitamin binding | "Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] | 9 | 2.614889e-02 | 1 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 8 | 3.596544e-02 | 1 |
| GO:MF | GO:0004602 | glutathione peroxidase activity | "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9, PMID:36771108] | 4 | 4.426846e-02 | 1 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:01230 | Biosynthesis of amino acids | Biosynthesis of amino acids | 18 | 1.391528e-13 | 1 |
| KEGG | KEGG:01200 | Carbon metabolism | Carbon metabolism | 21 | 2.708879e-13 | 1 |
| KEGG | KEGG:01100 | Metabolic pathways | Metabolic pathways | 67 | 4.049593e-10 | 1 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | Protein processing in endoplasmic reticulum | 19 | 3.902323e-08 | 1 |
| KEGG | KEGG:00010 | Glycolysis / Gluconeogenesis | Glycolysis / Gluconeogenesis | 12 | 3.974708e-07 | 1 |
| KEGG | KEGG:00030 | Pentose phosphate pathway | Pentose phosphate pathway | 7 | 1.485501e-04 | 1 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | Central carbon metabolism in cancer | 9 | 6.685600e-04 | 1 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | HIF-1 signaling pathway | 11 | 6.963315e-04 | 1 |
| KEGG | KEGG:00062 | Fatty acid elongation | Fatty acid elongation | 6 | 9.527978e-04 | 1 |
| KEGG | KEGG:00480 | Glutathione metabolism | Glutathione metabolism | 8 | 9.941505e-04 | 1 |
| KEGG | KEGG:05415 | Diabetic cardiomyopathy | Diabetic cardiomyopathy | 14 | 3.136013e-03 | 1 |
| KEGG | KEGG:00270 | Cysteine and methionine metabolism | Cysteine and methionine metabolism | 7 | 4.152308e-03 | 1 |
| KEGG | KEGG:05134 | Legionellosis | Legionellosis | 7 | 8.753152e-03 | 1 |
| KEGG | KEGG:00620 | Pyruvate metabolism | Pyruvate metabolism | 6 | 2.515927e-02 | 1 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | Chemical carcinogenesis - reactive oxygen species | 13 | 3.135136e-02 | 1 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4290 | Metabolic reprogramming in colon cancer | Metabolic reprogramming in colon cancer | 15 | 7.353842e-13 | 1 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 37 | 5.137914e-11 | 1 |
| WP | WP:WP534 | Glycolysis and gluconeogenesis | Glycolysis and gluconeogenesis | 14 | 5.755060e-11 | 1 |
| WP | WP:WP4628 | Aerobic glycolysis augmented | Aerobic glycolysis augmented | 9 | 1.173216e-10 | 1 |
| WP | WP:WP5355 | Metabolic epileptic disorders | Metabolic epileptic disorders | 17 | 1.397521e-09 | 1 |
| WP | WP:WP4018 | Clear cell renal cell carcinoma pathways | Clear cell renal cell carcinoma pathways | 15 | 5.953443e-08 | 1 |
| WP | WP:WP5049 | Glycolysis in senescence | Glycolysis in senescence | 7 | 1.258563e-07 | 1 |
| WP | WP:WP1946 | Cori cycle | Cori cycle | 8 | 1.757216e-07 | 1 |
| WP | WP:WP5312 | Metabolic pathways of fibroblasts | Metabolic pathways of fibroblasts | 9 | 3.227324e-06 | 1 |
| WP | WP:WP134 | Pentose phosphate metabolism | Pentose phosphate metabolism | 4 | 1.466445e-03 | 1 |
| WP | WP:WP5211 | Glucose metabolism in triple negative breast cancer cells | Glucose metabolism in triple negative breast cancer cells | 4 | 2.883365e-03 | 1 |
| WP | WP:WP2003 | miR targeted genes in leukocytes | miR targeted genes in leukocytes | 12 | 3.177800e-03 | 1 |
| WP | WP:WP3925 | Amino acid metabolism | Amino acid metabolism | 10 | 5.128340e-03 | 1 |
| WP | WP:WP5220 | Metabolic reprogramming in pancreatic cancer | Metabolic reprogramming in pancreatic cancer | 7 | 5.833398e-03 | 1 |
| WP | WP:WP2004 | miR targeted genes in lymphocytes | miR targeted genes in lymphocytes | 22 | 2.161365e-02 | 1 |
| WP | WP:WP5314 | Lactate shuttle in glial cells | Lactate shuttle in glial cells | 4 | 2.705187e-02 | 1 |
| WP | WP:WP4595 | Urea cycle and associated pathways | Urea cycle and associated pathways | 5 | 2.836204e-02 | 1 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00716_1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | Factor: ZF5; motif: GSGCGCGR; match class: 1 | 218 | 2.388375e-11 | 1 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 222 | 1.660659e-09 | 1 |
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 207 | 1.665429e-09 | 1 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 221 | 1.957218e-09 | 1 |
| TF | TF:M11529_1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 | 217 | 9.297227e-09 | 1 |
| TF | TF:M04869 | Factor: Egr-1; motif: GCGCATGCG | Factor: Egr-1; motif: GCGCATGCG | 186 | 1.382947e-08 | 1 |
| TF | TF:M09894_1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 | 212 | 1.662549e-08 | 1 |
| TF | TF:M07206 | Factor: E2F-1; motif: NGGGCGGGARV | Factor: E2F-1; motif: NGGGCGGGARV | 217 | 2.050657e-08 | 1 |
| TF | TF:M07206_1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 | 181 | 4.343415e-08 | 1 |
| TF | TF:M01240_1 | Factor: BEN; motif: CAGCGRNV; match class: 1 | Factor: BEN; motif: CAGCGRNV; match class: 1 | 204 | 7.243022e-08 | 1 |
| TF | TF:M02090_1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | Factor: E2F-4; motif: GCGGGAAANA; match class: 1 | 126 | 1.446665e-07 | 1 |
| TF | TF:M02090 | Factor: E2F-4; motif: GCGGGAAANA | Factor: E2F-4; motif: GCGGGAAANA | 191 | 1.562585e-07 | 1 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 227 | 1.563695e-07 | 1 |
| TF | TF:M12597_1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | Factor: E2F1; motif: GSGCGGGAAN; match class: 1 | 168 | 3.165192e-07 | 1 |
| TF | TF:M08266 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG | 212 | 5.300769e-07 | 1 |
| TF | TF:M11018_1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | 225 | 5.473785e-07 | 1 |
| TF | TF:M07395 | Factor: Sp1; motif: NGGGGCGGGGN | Factor: Sp1; motif: NGGGGCGGGGN | 176 | 5.852619e-07 | 1 |
| TF | TF:M11882_1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | 184 | 6.203557e-07 | 1 |
| TF | TF:M00803_1 | Factor: E2F; motif: GGCGSG; match class: 1 | Factor: E2F; motif: GGCGSG; match class: 1 | 171 | 6.522835e-07 | 1 |
| TF | TF:M10438 | Factor: ZF5; motif: GGSGCGCGS | Factor: ZF5; motif: GGSGCGCGS | 227 | 6.627547e-07 | 1 |
| TF | TF:M11530_1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | 204 | 6.902842e-07 | 1 |
| TF | TF:M09892 | Factor: E2F-1; motif: NNNNGGCGGGAARN | Factor: E2F-1; motif: NNNNGGCGGGAARN | 205 | 7.360169e-07 | 1 |
| TF | TF:M04869_1 | Factor: Egr-1; motif: GCGCATGCG; match class: 1 | Factor: Egr-1; motif: GCGCATGCG; match class: 1 | 171 | 8.542222e-07 | 1 |
| TF | TF:M12597 | Factor: E2F1; motif: GSGCGGGAAN | Factor: E2F1; motif: GSGCGGGAAN | 209 | 1.146485e-06 | 1 |
| TF | TF:M11531 | Factor: E2F-2; motif: GCGCGCGCGYW | Factor: E2F-2; motif: GCGCGCGCGYW | 202 | 1.309348e-06 | 1 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 172 | 2.024444e-06 | 1 |
| TF | TF:M11601_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 179 | 2.205869e-06 | 1 |
| TF | TF:M00196 | Factor: Sp1; motif: NGGGGGCGGGGYN | Factor: Sp1; motif: NGGGGGCGGGGYN | 170 | 2.352272e-06 | 1 |
| TF | TF:M08525_1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 | 219 | 2.439607e-06 | 1 |
| TF | TF:M09894 | Factor: E2F-4; motif: SNGGGCGGGAANN | Factor: E2F-4; motif: SNGGGCGGGAANN | 226 | 3.024218e-06 | 1 |
| TF | TF:M11882 | Factor: pax-6; motif: NYACGCNYSANYGMNCN | Factor: pax-6; motif: NYACGCNYSANYGMNCN | 220 | 4.330277e-06 | 1 |
| TF | TF:M09636_1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 | 208 | 7.959682e-06 | 1 |
| TF | TF:M04823 | Factor: E2F-4; motif: NNTTCCCGCCNN | Factor: E2F-4; motif: NNTTCCCGCCNN | 195 | 8.251262e-06 | 1 |
| TF | TF:M11880_1 | Factor: pax-6; motif: NYACGCWTSANYGMNCN; match class: 1 | Factor: pax-6; motif: NYACGCWTSANYGMNCN; match class: 1 | 129 | 8.308578e-06 | 1 |
| TF | TF:M12666 | Factor: SP1; motif: GGCCCCGCCCCCN | Factor: SP1; motif: GGCCCCGCCCCCN | 150 | 8.446547e-06 | 1 |
| TF | TF:M11530 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | 212 | 1.013249e-05 | 1 |
| TF | TF:M01783 | Factor: SP2; motif: GGGCGGGAC | Factor: SP2; motif: GGGCGGGAC | 155 | 1.120229e-05 | 1 |
| TF | TF:M11018 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | 230 | 1.332465e-05 | 1 |
| TF | TF:M00333 | Factor: ZF5; motif: NRNGNGCGCGCWN | Factor: ZF5; motif: NRNGNGCGCGCWN | 216 | 1.352550e-05 | 1 |
| TF | TF:M07250 | Factor: E2F-1; motif: NNNSSCGCSAANN | Factor: E2F-1; motif: NNNSSCGCSAANN | 173 | 1.403479e-05 | 1 |
| TF | TF:M11531_1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 | 190 | 1.826672e-05 | 1 |
| TF | TF:M09892_1 | Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 | Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 | 155 | 1.966129e-05 | 1 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 229 | 2.164545e-05 | 1 |
| TF | TF:M12173 | Factor: GKLF; motif: NNCCMCRCCCN | Factor: GKLF; motif: NNCCMCRCCCN | 164 | 2.629371e-05 | 1 |
| TF | TF:M07380 | Factor: E2F-4; motif: NTTTCSCGCC | Factor: E2F-4; motif: NTTTCSCGCC | 196 | 3.070609e-05 | 1 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 220 | 4.241921e-05 | 1 |
| TF | TF:M08207_1 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 | 218 | 5.345806e-05 | 1 |
| TF | TF:M11603_1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 | 197 | 5.805849e-05 | 1 |
| TF | TF:M00333_1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 | 189 | 9.167130e-05 | 1 |
| TF | TF:M04106 | Factor: RUNX2; motif: NRACCGCAAACCGCAN | Factor: RUNX2; motif: NRACCGCAAACCGCAN | 202 | 9.650525e-05 | 1 |
| TF | TF:M11529 | Factor: E2F-2; motif: GCGCGCGCNCS | Factor: E2F-2; motif: GCGCGCGCNCS | 224 | 1.128117e-04 | 1 |
| TF | TF:M01588 | Factor: GKLF; motif: GCCMCRCCCNNN | Factor: GKLF; motif: GCCMCRCCCNNN | 149 | 1.376537e-04 | 1 |
| TF | TF:M03920 | Factor: SP1; motif: RCCMCRCCCMC | Factor: SP1; motif: RCCMCRCCCMC | 129 | 1.427386e-04 | 1 |
| TF | TF:M09723 | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS | Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS | 162 | 1.627862e-04 | 1 |
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 215 | 1.644634e-04 | 1 |
| TF | TF:M03976 | Factor: ERG; motif: ACCGGAWATCCGGT | Factor: ERG; motif: ACCGGAWATCCGGT | 191 | 1.676210e-04 | 1 |
| TF | TF:M08207 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT | 229 | 1.705742e-04 | 1 |
| TF | TF:M08205 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | 208 | 1.798545e-04 | 1 |
| TF | TF:M09868 | Factor: ATF-3; motif: GGTSACGTGAN | Factor: ATF-3; motif: GGTSACGTGAN | 116 | 1.874668e-04 | 1 |
| TF | TF:M12599 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN | 230 | 1.932741e-04 | 1 |
| TF | TF:M11601 | Factor: TCF-1; motif: ACATCGRGRCGCTGW | Factor: TCF-1; motif: ACATCGRGRCGCTGW | 211 | 1.995871e-04 | 1 |
| TF | TF:M07084 | Factor: E2F-4; motif: NGGCGGGAARN | Factor: E2F-4; motif: NGGCGGGAARN | 171 | 2.171242e-04 | 1 |
| TF | TF:M00736 | Factor: E2F-1:DP-1; motif: TTTCSCGC | Factor: E2F-1:DP-1; motif: TTTCSCGC | 165 | 2.680855e-04 | 1 |
| TF | TF:M04950 | Factor: Egr-1; motif: NGCGTGCGY | Factor: Egr-1; motif: NGCGTGCGY | 171 | 2.846678e-04 | 1 |
| TF | TF:M00938 | Factor: E2F-1; motif: TTGGCGCGRAANNGNM | Factor: E2F-1; motif: TTGGCGCGRAANNGNM | 128 | 2.975414e-04 | 1 |
| TF | TF:M04691 | Factor: Kaiso; motif: TCTCGCGAG | Factor: Kaiso; motif: TCTCGCGAG | 213 | 3.607860e-04 | 1 |
| TF | TF:M12186 | Factor: BTEB4; motif: NCCACGCCCM | Factor: BTEB4; motif: NCCACGCCCM | 150 | 3.702309e-04 | 1 |
| TF | TF:M00931 | Factor: Sp1; motif: GGGGCGGGGC | Factor: Sp1; motif: GGGGCGGGGC | 164 | 3.908248e-04 | 1 |
| TF | TF:M04516 | Factor: E2F-1; motif: TTTGGCGCCAAA | Factor: E2F-1; motif: TTTGGCGCCAAA | 176 | 4.002241e-04 | 1 |
| TF | TF:M02089 | Factor: E2F-3; motif: GGCGGGN | Factor: E2F-3; motif: GGCGGGN | 195 | 4.004316e-04 | 1 |
| TF | TF:M04516_1 | Factor: E2F-1; motif: TTTGGCGCCAAA; match class: 1 | Factor: E2F-1; motif: TTTGGCGCCAAA; match class: 1 | 163 | 4.519230e-04 | 1 |
| TF | TF:M08225_1 | Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 | Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 | 136 | 4.898805e-04 | 1 |
| TF | TF:M04826 | Factor: p300; motif: ACNTCCG | Factor: p300; motif: ACNTCCG | 233 | 5.448077e-04 | 1 |
| TF | TF:M08205_1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | 165 | 5.558797e-04 | 1 |
| TF | TF:M04107 | Factor: RUNX2; motif: WRACCGCANWAACCGCAN | Factor: RUNX2; motif: WRACCGCANWAACCGCAN | 186 | 5.657976e-04 | 1 |
| TF | TF:M04515 | Factor: E2F-1; motif: WWTGGCGCCAAA | Factor: E2F-1; motif: WWTGGCGCCAAA | 196 | 5.868008e-04 | 1 |
| TF | TF:M10072 | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR | 166 | 6.042522e-04 | 1 |
| TF | TF:M04515_1 | Factor: E2F-1; motif: WWTGGCGCCAAA; match class: 1 | Factor: E2F-1; motif: WWTGGCGCCAAA; match class: 1 | 184 | 6.443772e-04 | 1 |
| TF | TF:M04823_1 | Factor: E2F-4; motif: NNTTCCCGCCNN; match class: 1 | Factor: E2F-4; motif: NNTTCCCGCCNN; match class: 1 | 134 | 6.708398e-04 | 1 |
| TF | TF:M01240 | Factor: BEN; motif: CAGCGRNV | Factor: BEN; motif: CAGCGRNV | 224 | 7.359930e-04 | 1 |
| TF | TF:M03567 | Factor: Sp2; motif: NYSGCCCCGCCCCCY | Factor: Sp2; motif: NYSGCCCCGCCCCCY | 132 | 7.978731e-04 | 1 |
| TF | TF:M08266_1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | 147 | 8.159341e-04 | 1 |
| TF | TF:M10530 | Factor: sp4; motif: NNNGCYCCGCCCCCY | Factor: sp4; motif: NNNGCYCCGCCCCCY | 138 | 8.421868e-04 | 1 |
| TF | TF:M00986_1 | Factor: Churchill; motif: CGGGNN; match class: 1 | Factor: Churchill; motif: CGGGNN; match class: 1 | 164 | 8.556143e-04 | 1 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 91 | 8.915840e-04 | 1 |
| TF | TF:M13135 | Factor: SP4; motif: GGCCCCGCCCCCN | Factor: SP4; motif: GGCCCCGCCCCCN | 104 | 9.190587e-04 | 1 |
| TF | TF:M00695_1 | Factor: ETF; motif: GVGGMGG; match class: 1 | Factor: ETF; motif: GVGGMGG; match class: 1 | 123 | 9.527285e-04 | 1 |
| TF | TF:M07250_1 | Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 | Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 | 103 | 9.887062e-04 | 1 |
| TF | TF:M11435 | Factor: Elk-1; motif: NNCCGGAAGTN | Factor: Elk-1; motif: NNCCGGAAGTN | 177 | 1.700133e-03 | 1 |
| TF | TF:M04106_1 | Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 | Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 | 139 | 1.768606e-03 | 1 |
| TF | TF:M09896 | Factor: E2F-7; motif: GRGGCGGGAANNN | Factor: E2F-7; motif: GRGGCGGGAANNN | 158 | 1.782190e-03 | 1 |
| TF | TF:M13366 | Factor: ZBED4; motif: CCCGCYCCGC | Factor: ZBED4; motif: CCCGCYCCGC | 130 | 2.221033e-03 | 1 |
| TF | TF:M13124_1 | Factor: ZNF670; motif: SNGGGCRGRG; match class: 1 | Factor: ZNF670; motif: SNGGGCRGRG; match class: 1 | 136 | 2.864737e-03 | 1 |
| TF | TF:M09826 | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC | Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC | 176 | 3.033736e-03 | 1 |
| TF | TF:M12590 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN | 169 | 3.087291e-03 | 1 |
| TF | TF:M09970 | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN | 130 | 3.253398e-03 | 1 |
| TF | TF:M00428 | Factor: E2F-1; motif: NKTSSCGC | Factor: E2F-1; motif: NKTSSCGC | 145 | 3.300371e-03 | 1 |
| TF | TF:M07380_1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 | 133 | 4.183693e-03 | 1 |
| TF | TF:M00932 | Factor: Sp1; motif: NNGGGGCGGGGNN | Factor: Sp1; motif: NNGGGGCGGGGNN | 162 | 4.770309e-03 | 1 |
| TF | TF:M08523_1 | Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN; match class: 1 | Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN; match class: 1 | 125 | 4.972518e-03 | 1 |
| TF | TF:M12598 | Factor: E2F3; motif: NNRGMKGGAR | Factor: E2F3; motif: NNRGMKGGAR | 184 | 5.029896e-03 | 1 |
| TF | TF:M03876 | Factor: Kaiso; motif: GCMGGGRGCRGS | Factor: Kaiso; motif: GCMGGGRGCRGS | 196 | 5.166330e-03 | 1 |
| TF | TF:M09765 | Factor: SP1; motif: NRGKGGGCGGGGCN | Factor: SP1; motif: NRGKGGGCGGGGCN | 126 | 5.791775e-03 | 1 |
| TF | TF:M07409 | Factor: BTEB2; motif: GCCCCRCCCH | Factor: BTEB2; motif: GCCCCRCCCH | 96 | 6.303223e-03 | 1 |
| TF | TF:M00008 | Factor: Sp1; motif: GGGGCGGGGT | Factor: Sp1; motif: GGGGCGGGGT | 157 | 7.111617e-03 | 1 |
| TF | TF:M01660 | Factor: GABP-alpha; motif: CTTCCK | Factor: GABP-alpha; motif: CTTCCK | 168 | 7.464670e-03 | 1 |
| TF | TF:M02071 | Factor: ETV7; motif: NCCGGAANNN | Factor: ETV7; motif: NCCGGAANNN | 157 | 7.817527e-03 | 1 |
| TF | TF:M09817 | Factor: PAX5; motif: RNGCGTGACCNN | Factor: PAX5; motif: RNGCGTGACCNN | 183 | 8.575248e-03 | 1 |
| TF | TF:M08523 | Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN | Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN | 180 | 8.824508e-03 | 1 |
| TF | TF:M00428_1 | Factor: E2F-1; motif: NKTSSCGC; match class: 1 | Factor: E2F-1; motif: NKTSSCGC; match class: 1 | 73 | 9.039855e-03 | 1 |
| TF | TF:M03989 | Factor: FLI1; motif: ACCGGAAATCCGGT | Factor: FLI1; motif: ACCGGAAATCCGGT | 160 | 9.196788e-03 | 1 |
| TF | TF:M01857 | Factor: AP-2alpha; motif: NGCCYSNNGSN | Factor: AP-2alpha; motif: NGCCYSNNGSN | 146 | 9.258625e-03 | 1 |
| TF | TF:M11396 | Factor: Erg; motif: NACCGGAARTN | Factor: Erg; motif: NACCGGAARTN | 164 | 9.271961e-03 | 1 |
| TF | TF:M11883 | Factor: pax-6; motif: NYACGCNTSRNYGCNYN | Factor: pax-6; motif: NYACGCNTSRNYGCNYN | 193 | 9.343161e-03 | 1 |
| TF | TF:M12186_1 | Factor: BTEB4; motif: NCCACGCCCM; match class: 1 | Factor: BTEB4; motif: NCCACGCCCM; match class: 1 | 78 | 9.525006e-03 | 1 |
| TF | TF:M12351_1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 | 133 | 9.648188e-03 | 1 |
| TF | TF:M05439 | Factor: RREB-1; motif: GGGWCSA | Factor: RREB-1; motif: GGGWCSA | 139 | 1.100379e-02 | 1 |
| TF | TF:M09895 | Factor: E2F-6; motif: NGGGCGGGARRNN | Factor: E2F-6; motif: NGGGCGGGARRNN | 129 | 1.237213e-02 | 1 |
| TF | TF:M11603 | Factor: TCF-1; motif: ACATCGRGRCGCTGW | Factor: TCF-1; motif: ACATCGRGRCGCTGW | 220 | 1.238910e-02 | 1 |
| TF | TF:M11393 | Factor: Erg; motif: NACCGGATATCCGGTN | Factor: Erg; motif: NACCGGATATCCGGTN | 199 | 1.286983e-02 | 1 |
| TF | TF:M13032_1 | Factor: ETV5; motif: ACCGGAAGTN; match class: 1 | Factor: ETV5; motif: ACCGGAAGTN; match class: 1 | 71 | 1.289277e-02 | 1 |
| TF | TF:M07039_1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | Factor: ETF; motif: CCCCGCCCCYN; match class: 1 | 195 | 1.326371e-02 | 1 |
| TF | TF:M04710 | Factor: CHD2; motif: TCTCGCGAG | Factor: CHD2; motif: TCTCGCGAG | 199 | 1.462448e-02 | 1 |
| TF | TF:M02089_1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | Factor: E2F-3; motif: GGCGGGN; match class: 1 | 148 | 1.484441e-02 | 1 |
| TF | TF:M11535 | Factor: E2F-4; motif: TTTTGGCGCCAWWN | Factor: E2F-4; motif: TTTTGGCGCCAWWN | 165 | 1.511882e-02 | 1 |
| TF | TF:M00189 | Factor: AP-2; motif: MKCCCSCNGGCG | Factor: AP-2; motif: MKCCCSCNGGCG | 162 | 1.515071e-02 | 1 |
| TF | TF:M04918 | Factor: Egr-1; motif: ACCGCCC | Factor: Egr-1; motif: ACCGCCC | 100 | 1.515356e-02 | 1 |
| TF | TF:M04744 | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA | 155 | 1.560737e-02 | 1 |
| TF | TF:M13147_1 | Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN; match class: 1 | Factor: ZNF253; motif: SNGNSCGNGGNGCKGNN; match class: 1 | 113 | 1.837080e-02 | 1 |
| TF | TF:M10071 | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG | Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG | 137 | 1.862976e-02 | 1 |
| TF | TF:M03807 | Factor: SP2; motif: GNNGGGGGCGGGGSN | Factor: SP2; motif: GNNGGGGGCGGGGSN | 136 | 1.905261e-02 | 1 |
| TF | TF:M11382_1 | Factor: ESE-1; motif: NWTRCGGAWGCN; match class: 1 | Factor: ESE-1; motif: NWTRCGGAWGCN; match class: 1 | 79 | 1.944965e-02 | 1 |
| TF | TF:M02065 | Factor: ER81; motif: RCCGGAARYN | Factor: ER81; motif: RCCGGAARYN | 185 | 1.993811e-02 | 1 |
| TF | TF:M11058_1 | Factor: Hey1; motif: NGCRCGYGYN; match class: 1 | Factor: Hey1; motif: NGCRCGYGYN; match class: 1 | 153 | 2.047930e-02 | 1 |
| TF | TF:M08525 | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM | Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM | 226 | 2.205548e-02 | 1 |
| TF | TF:M00986 | Factor: Churchill; motif: CGGGNN | Factor: Churchill; motif: CGGGNN | 200 | 2.232359e-02 | 1 |
| TF | TF:M09636 | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG | Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG | 219 | 2.338021e-02 | 1 |
| TF | TF:M11400 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 153 | 2.487770e-02 | 1 |
| TF | TF:M09893 | Factor: E2F-3; motif: NNGGCGGGAAA | Factor: E2F-3; motif: NNGGCGGGAAA | 105 | 2.562203e-02 | 1 |
| TF | TF:M11382 | Factor: ESE-1; motif: NWTRCGGAWGCN | Factor: ESE-1; motif: NWTRCGGAWGCN | 157 | 2.826737e-02 | 1 |
| TF | TF:M09817_1 | Factor: PAX5; motif: RNGCGTGACCNN; match class: 1 | Factor: PAX5; motif: RNGCGTGACCNN; match class: 1 | 106 | 2.917142e-02 | 1 |
| TF | TF:M09918 | Factor: Pet-1; motif: GCNGGAAGYG | Factor: Pet-1; motif: GCNGGAAGYG | 193 | 2.964571e-02 | 1 |
| TF | TF:M12227 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN | Factor: ZIC4; motif: NNCCNCCCRYNGYGN | 166 | 3.249713e-02 | 1 |
| TF | TF:M08226 | Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG | Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG | 176 | 3.272185e-02 | 1 |
| TF | TF:M11883_1 | Factor: pax-6; motif: NYACGCNTSRNYGCNYN; match class: 1 | Factor: pax-6; motif: NYACGCNTSRNYGCNYN; match class: 1 | 126 | 3.428816e-02 | 1 |
| TF | TF:M09967 | Factor: AP-2rep; motif: NGGGGCGGGGC | Factor: AP-2rep; motif: NGGGGCGGGGC | 77 | 3.438151e-02 | 1 |
| TF | TF:M11424 | Factor: Erm; motif: NNSCGGAWGYN | Factor: Erm; motif: NNSCGGAWGYN | 131 | 3.485406e-02 | 1 |
| TF | TF:M13132 | Factor: ZNF609; motif: GNSNGGGNGCTGN | Factor: ZNF609; motif: GNSNGGGNGCTGN | 170 | 3.530663e-02 | 1 |
| TF | TF:M07226 | Factor: SP1; motif: NCCCCKCCCCC | Factor: SP1; motif: NCCCCKCCCCC | 133 | 3.588440e-02 | 1 |
| TF | TF:M11393_1 | Factor: Erg; motif: NACCGGATATCCGGTN; match class: 1 | Factor: Erg; motif: NACCGGATATCCGGTN; match class: 1 | 193 | 3.670137e-02 | 1 |
| TF | TF:M05386 | Factor: KLF17; motif: NGGGCGG | Factor: KLF17; motif: NGGGCGG | 128 | 3.979240e-02 | 1 |
| TF | TF:M05499 | Factor: LKLF; motif: NGGGCGG | Factor: LKLF; motif: NGGGCGG | 128 | 3.979240e-02 | 1 |
| TF | TF:M08441_1 | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 | 184 | 4.016369e-02 | 1 |
| TF | TF:M00933 | Factor: Sp1; motif: CCCCGCCCCN | Factor: Sp1; motif: CCCCGCCCCN | 150 | 4.359119e-02 | 1 |
| TF | TF:M12598_1 | Factor: E2F3; motif: NNRGMKGGAR; match class: 1 | Factor: E2F3; motif: NNRGMKGGAR; match class: 1 | 116 | 4.359549e-02 | 1 |
| TF | TF:M13124 | Factor: ZNF670; motif: SNGGGCRGRG | Factor: ZNF670; motif: SNGGGCRGRG | 184 | 4.422362e-02 | 1 |
| TF | TF:M08441 | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG | Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG | 219 | 4.594261e-02 | 1 |
| TF | TF:M01770_1 | Factor: XBP-1; motif: WNNGMCACGTC; match class: 1 | Factor: XBP-1; motif: WNNGMCACGTC; match class: 1 | 84 | 4.613629e-02 | 1 |
| TF | TF:M09632 | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN | 61 | 4.820607e-02 | 1 |
| TF | TF:M00327 | Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN | Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN | 189 | 4.949531e-02 | 1 |
| TF | TF:M11427_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 84 | 4.974965e-02 | 1 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 41 | 2.164509e-08 | 1 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 43 | 4.037296e-05 | 1 |
| MIRNA | MIRNA:hsa-mir-222-3p | hsa-mir-222-3p | hsa-mir-222-3p | 20 | 2.383999e-04 | 1 |
| MIRNA | MIRNA:hsa-mir-4489 | hsa-mir-4489 | hsa-mir-4489 | 30 | 1.566757e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 46 | 4.069280e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-331-3p | hsa-mir-331-3p | hsa-mir-331-3p | 37 | 4.538392e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-4267 | hsa-mir-4267 | hsa-mir-4267 | 39 | 5.346073e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-15b-5p | hsa-mir-15b-5p | hsa-mir-15b-5p | 26 | 6.275709e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 18 | 6.904779e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-3175 | hsa-mir-3175 | hsa-mir-3175 | 47 | 6.910894e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 41 | 8.154354e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-890 | hsa-mir-890 | hsa-mir-890 | 33 | 9.565433e-03 | 1 |
| MIRNA | MIRNA:hsa-mir-625 | hsa-mir-625 | hsa-mir-625 | 39 | 1.239214e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-3940-5p | hsa-mir-3940-5p | hsa-mir-3940-5p | 24 | 1.257752e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4507 | hsa-mir-4507 | hsa-mir-4507 | 24 | 1.289675e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-324-5p | hsa-mir-324-5p | hsa-mir-324-5p | 27 | 1.320286e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4290 | hsa-mir-4290 | hsa-mir-4290 | 28 | 1.875468e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-26a-5p | hsa-mir-26a-5p | hsa-mir-26a-5p | 18 | 2.511531e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-323-5p | hsa-mir-323-5p | hsa-mir-323-5p | 28 | 3.014118e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-195-5p | hsa-mir-195-5p | hsa-mir-195-5p | 22 | 3.061930e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-133a-3p | hsa-mir-133a-3p | hsa-mir-133a-3p | 9 | 3.317297e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-4283 | hsa-mir-4283 | hsa-mir-4283 | 31 | 3.775712e-02 | 1 |
| MIRNA | MIRNA:hsa-mir-335 | hsa-mir-335 | hsa-mir-335 | 31 | 4.133294e-02 | 1 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-70263 | Gluconeogenesis | Gluconeogenesis | 8 | 0.000002 | 1 |
| REAC | REAC:R-HSA-1430728 | Metabolism | Metabolism | 71 | 0.000004 | 1 |
| REAC | REAC:R-HSA-9837999 | Mitochondrial protein degradation | Mitochondrial protein degradation | 13 | 0.000008 | 1 |
| REAC | REAC:R-HSA-8949613 | Cristae formation | Cristae formation | 8 | 0.000022 | 1 |
| REAC | REAC:R-HSA-3299685 | Detoxification of Reactive Oxygen Species | Detoxification of Reactive Oxygen Species | 8 | 0.000062 | 1 |
| REAC | REAC:R-HSA-1428517 | Aerobic respiration and respiratory electron transport | Aerobic respiration and respiratory electron transport | 17 | 0.000080 | 1 |
| REAC | REAC:R-HSA-9711123 | Cellular response to chemical stress | Cellular response to chemical stress | 17 | 0.000086 | 1 |
| REAC | REAC:R-HSA-163210 | Formation of ATP by chemiosmotic coupling | Formation of ATP by chemiosmotic coupling | 6 | 0.000210 | 1 |
| REAC | REAC:R-HSA-1592230 | Mitochondrial biogenesis | Mitochondrial biogenesis | 11 | 0.000265 | 1 |
| REAC | REAC:R-HSA-447115 | Interleukin-12 family signaling | Interleukin-12 family signaling | 9 | 0.000340 | 1 |
| REAC | REAC:R-HSA-9020591 | Interleukin-12 signaling | Interleukin-12 signaling | 8 | 0.000817 | 1 |
| REAC | REAC:R-HSA-70171 | Glycolysis | Glycolysis | 9 | 0.001351 | 1 |
| REAC | REAC:R-HSA-6798695 | Neutrophil degranulation | Neutrophil degranulation | 24 | 0.001678 | 1 |
| REAC | REAC:R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 7 | 0.001842 | 1 |
| REAC | REAC:R-HSA-446203 | Asparagine N-linked glycosylation | Asparagine N-linked glycosylation | 18 | 0.003655 | 1 |
| REAC | REAC:R-HSA-70326 | Glucose metabolism | Glucose metabolism | 9 | 0.003854 | 1 |
| REAC | REAC:R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 6 | 0.004574 | 1 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 32 | 0.004577 | 1 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 32 | 0.006526 | 1 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 60 | 0.014998 | 1 |
| REAC | REAC:R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | Mitochondrial Fatty Acid Beta-Oxidation | 6 | 0.019896 | 1 |
| REAC | REAC:R-HSA-3371511 | HSF1 activation | HSF1 activation | 4 | 0.019975 | 1 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0004354 | Abnormal circulating carboxylic acid concentration | Any deviation from the normal concentration of a carboxylic acid in the blood circulation. | 27 | 0.000097 | 1 |
| HP | HP:0001941 | Acidosis | Abnormal acid accumulation or depletion of base. | 27 | 0.000215 | 1 |
| HP | HP:0004360 | Abnormality of acid-base homeostasis | An abnormality of the balance or maintenance of the balance of acids and bases in bodily fluids, resulting in an abnormal pH. | 28 | 0.000250 | 1 |
| HP | HP:0002151 | Increased circulating lactate concentration | Abnormally increased level of blood lactate (2-hydroxypropanoic acid). Lactate is produced from pyruvate by lactate dehydrogenase during normal metabolism. The terms lactate and lactic acid are often used interchangeably but lactate (the component measured in blood) is strictly a weak base whereas lactic acid is the corresponding acid. Lactic acidosis is often used clinically to describe elevated lactate but should be reserved for cases where there is a corresponding acidosis (pH below 7.35). | 18 | 0.001284 | 1 |
| HP | HP:0430071 | Abnormal circulating organic compound concentration | Any deviation of the concentration of an orrganic compound from the normal range. An organic compound is defined as any compound that contains a carbon atom. | 37 | 0.002421 | 1 |
| HP | HP:0001987 | Hyperammonemia | An increased concentration of ammonia in the blood. | 11 | 0.002506 | 1 |
| HP | HP:0001939 | Abnormality of metabolism/homeostasis | Abnormality of metabolism/homeostasis | 83 | 0.005896 | 1 |
| HP | HP:0003110 | Abnormality of urine homeostasis | An abnormality of the composition of urine or the levels of its components. | 35 | 0.016866 | 1 |
| HP | HP:0033354 | Abnormal urine metabolite level | Any deviation from the normal amount of a metabolite in urine. | 30 | 0.022303 | 1 |
| HP | HP:0011277 | Abnormality of the urinary system physiology | Abnormality of the urinary system physiology | 45 | 0.024724 | 1 |
| HP | HP:0001396 | Cholestasis | Impairment of bile flow due to obstruction in bile ducts. | 19 | 0.026327 | 1 |
| HP | HP:0032180 | Abnormal circulating metabolite concentration | An abnormal level of an analyte measured in the blood. | 53 | 0.032444 | 1 |
| HP | HP:0002157 | Azotemia | An increased concentration of nitrogen compounds in the blood. | 14 | 0.040128 | 1 |
| HP | HP:0001930 | Nonspherocytic hemolytic anemia | Nonspherocytic hemolytic anemia | 4 | 0.044741 | 1 |
| HP | HP:0034684 | Abnormal enzyme concentration or activity | Concentration or activity of an enzyme is above or below the limits of normal. | 33 | 0.049647 | 1 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6289 | prohibitin 2 complex, mitochondrial | prohibitin 2 complex, mitochondrial | 3 | 0.025058 | 1 |
| CORUM | CORUM:1199 | Oligosaccharyltransferase complex (Stt3A variant) | Oligosaccharyltransferase complex (Stt3A variant) | 3 | 0.049251 | 1 |
Community 2
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0002181 | cytoplasmic translation | "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] | 75 | 3.868239e-121 | 2 |
| GO:BP | GO:0006412 | translation | "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] | 93 | 7.441501e-96 | 2 |
| GO:BP | GO:0042254 | ribosome biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] | 43 | 7.340968e-40 | 2 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 106 | 2.224645e-34 | 2 |
| GO:BP | GO:0010467 | gene expression | "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] | 133 | 1.295788e-29 | 2 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 134 | 2.618871e-28 | 2 |
| GO:BP | GO:0042274 | ribosomal small subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 24 | 6.814787e-27 | 2 |
| GO:BP | GO:0009058 | biosynthetic process | "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] | 134 | 6.180947e-23 | 2 |
| GO:BP | GO:0043170 | macromolecule metabolic process | "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 139 | 1.720635e-21 | 2 |
| GO:BP | GO:0044238 | primary metabolic process | "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] | 140 | 3.061386e-21 | 2 |
| GO:BP | GO:0006364 | rRNA processing | "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] | 26 | 4.092761e-21 | 2 |
| GO:BP | GO:0016072 | rRNA metabolic process | "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] | 27 | 1.667618e-20 | 2 |
| GO:BP | GO:0022613 | ribonucleoprotein complex biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] | 55 | 2.455951e-18 | 2 |
| GO:BP | GO:0006417 | regulation of translation | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 28 | 1.499504e-17 | 2 |
| GO:BP | GO:0042255 | ribosome assembly | "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428] | 15 | 3.673431e-16 | 2 |
| GO:BP | GO:0008152 | metabolic process | "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] | 141 | 1.227365e-14 | 2 |
| GO:BP | GO:0006413 | translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] | 15 | 2.403106e-11 | 2 |
| GO:BP | GO:0140694 | membraneless organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] | 23 | 6.027728e-11 | 2 |
| GO:BP | GO:0045727 | positive regulation of translation | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] | 15 | 8.404586e-11 | 2 |
| GO:BP | GO:0042273 | ribosomal large subunit biogenesis | "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] | 12 | 1.160551e-10 | 2 |
| GO:BP | GO:1903311 | regulation of mRNA metabolic process | "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 19 | 1.239262e-09 | 2 |
| GO:BP | GO:0006402 | mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 17 | 7.446504e-09 | 2 |
| GO:BP | GO:0006401 | RNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 18 | 1.508595e-08 | 2 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 41 | 2.773440e-08 | 2 |
| GO:BP | GO:0010608 | post-transcriptional regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] | 31 | 3.009086e-08 | 2 |
| GO:BP | GO:0141188 | nucleic acid catabolic process | "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators] | 18 | 6.174210e-08 | 2 |
| GO:BP | GO:0006403 | RNA localization | "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] | 14 | 2.468814e-07 | 2 |
| GO:BP | GO:0006396 | RNA processing | "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] | 55 | 2.658971e-07 | 2 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 70 | 3.369346e-07 | 2 |
| GO:BP | GO:1901798 | positive regulation of signal transduction by p53 class mediator | "Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 7 | 1.322144e-06 | 2 |
| GO:BP | GO:0001732 | formation of cytoplasmic translation initiation complex | "Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd, PMID:29735639] | 6 | 1.422648e-06 | 2 |
| GO:BP | GO:0002183 | cytoplasmic translational initiation | "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] | 8 | 1.753859e-06 | 2 |
| GO:BP | GO:0061013 | regulation of mRNA catabolic process | "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] | 13 | 2.542701e-06 | 2 |
| GO:BP | GO:0000956 | nuclear-transcribed mRNA catabolic process | "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] | 11 | 2.654912e-06 | 2 |
| GO:BP | GO:1903312 | negative regulation of mRNA metabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 10 | 4.502291e-06 | 2 |
| GO:BP | GO:0050684 | regulation of mRNA processing | "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] | 11 | 4.706096e-06 | 2 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 32 | 4.777463e-06 | 2 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] | 87 | 5.448441e-06 | 2 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 27 | 5.663848e-06 | 2 |
| GO:BP | GO:0010628 | positive regulation of gene expression | "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 29 | 8.518427e-06 | 2 |
| GO:BP | GO:0043484 | regulation of RNA splicing | "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] | 12 | 1.447284e-05 | 2 |
| GO:BP | GO:0000027 | ribosomal large subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428] | 6 | 2.283460e-05 | 2 |
| GO:BP | GO:0048255 | mRNA stabilization | "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid] | 8 | 4.908526e-05 | 2 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 50 | 4.970593e-05 | 2 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 18 | 7.001753e-05 | 2 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 88 | 1.077947e-04 | 2 |
| GO:BP | GO:0043488 | regulation of mRNA stability | "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] | 11 | 1.086535e-04 | 2 |
| GO:BP | GO:2000767 | positive regulation of cytoplasmic translation | "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 5 | 1.143675e-04 | 2 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 52 | 1.250712e-04 | 2 |
| GO:BP | GO:0043489 | RNA stabilization | "Prevention of degradation of RNA molecules." [GOC:go_curators] | 8 | 1.305450e-04 | 2 |
| GO:BP | GO:1902373 | negative regulation of mRNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865] | 8 | 1.444024e-04 | 2 |
| GO:BP | GO:0030490 | maturation of SSU-rRNA | "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators] | 7 | 1.487595e-04 | 2 |
| GO:BP | GO:0048024 | regulation of mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 9 | 1.660328e-04 | 2 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 42 | 1.797789e-04 | 2 |
| GO:BP | GO:0016070 | RNA metabolic process | "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] | 79 | 1.865113e-04 | 2 |
| GO:BP | GO:0043487 | regulation of RNA stability | "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl] | 11 | 2.090431e-04 | 2 |
| GO:BP | GO:0000028 | ribosomal small subunit assembly | "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl, PMID:30467428] | 5 | 2.218212e-04 | 2 |
| GO:BP | GO:0050657 | nucleic acid transport | "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] | 10 | 3.406303e-04 | 2 |
| GO:BP | GO:0050658 | RNA transport | "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 10 | 3.406303e-04 | 2 |
| GO:BP | GO:0051236 | establishment of RNA localization | "The directed movement of RNA to a specific location." [GOC:ai] | 10 | 4.051049e-04 | 2 |
| GO:BP | GO:0051438 | regulation of ubiquitin-protein transferase activity | "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] | 6 | 4.321035e-04 | 2 |
| GO:BP | GO:1902369 | negative regulation of RNA catabolic process | "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] | 8 | 4.383560e-04 | 2 |
| GO:BP | GO:0070925 | organelle assembly | "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 24 | 4.749659e-04 | 2 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 42 | 5.303488e-04 | 2 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 66 | 5.481472e-04 | 2 |
| GO:BP | GO:0051028 | mRNA transport | "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 9 | 5.981147e-04 | 2 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 70 | 7.130364e-04 | 2 |
| GO:BP | GO:0070934 | CRD-mediated mRNA stabilization | "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303] | 4 | 1.300901e-03 | 2 |
| GO:BP | GO:1903313 | positive regulation of mRNA metabolic process | "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 9 | 1.421732e-03 | 2 |
| GO:BP | GO:1901796 | regulation of signal transduction by p53 class mediator | "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] | 8 | 1.424262e-03 | 2 |
| GO:BP | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] | 6 | 1.595901e-03 | 2 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 23 | 1.617216e-03 | 2 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 21 | 2.555084e-03 | 2 |
| GO:BP | GO:0010629 | negative regulation of gene expression | "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 30 | 2.720235e-03 | 2 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 13 | 2.848055e-03 | 2 |
| GO:BP | GO:0141187 | nucleic acid biosynthetic process | "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] | 75 | 3.109668e-03 | 2 |
| GO:BP | GO:0032774 | RNA biosynthetic process | "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] | 74 | 3.496922e-03 | 2 |
| GO:BP | GO:0010468 | regulation of gene expression | "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] | 65 | 3.577864e-03 | 2 |
| GO:BP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] | 9 | 5.650930e-03 | 2 |
| GO:BP | GO:0034063 | stress granule assembly | "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519] | 5 | 6.583254e-03 | 2 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 70 | 6.812625e-03 | 2 |
| GO:BP | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 6 | 6.905508e-03 | 2 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 65 | 7.262088e-03 | 2 |
| GO:BP | GO:0017148 | negative regulation of translation | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] | 8 | 7.465010e-03 | 2 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] | 9 | 7.864069e-03 | 2 |
| GO:BP | GO:0048026 | positive regulation of mRNA splicing, via spliceosome | "Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 5 | 8.819477e-03 | 2 |
| GO:BP | GO:2000765 | regulation of cytoplasmic translation | "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] | 5 | 1.014034e-02 | 2 |
| GO:BP | GO:0015931 | nucleobase-containing compound transport | "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 10 | 1.205785e-02 | 2 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 10 | 1.298154e-02 | 2 |
| GO:BP | GO:0050685 | positive regulation of mRNA processing | "Any process that activates or increases the frequency, rate or extent of mRNA processing." [GOC:ai] | 5 | 1.324415e-02 | 2 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 16 | 1.340900e-02 | 2 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 43 | 1.349659e-02 | 2 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 10 | 1.556310e-02 | 2 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 39 | 1.568731e-02 | 2 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 30 | 1.602396e-02 | 2 |
| GO:BP | GO:0016071 | mRNA metabolic process | "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 33 | 1.774716e-02 | 2 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] | 75 | 1.781449e-02 | 2 |
| GO:BP | GO:1904666 | regulation of ubiquitin protein ligase activity | "Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882] | 4 | 1.818613e-02 | 2 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 9 | 1.870948e-02 | 2 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 65 | 2.031545e-02 | 2 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 70 | 2.646352e-02 | 2 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 39 | 2.789623e-02 | 2 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 44 | 3.130089e-02 | 2 |
| GO:BP | GO:1903608 | protein localization to cytoplasmic stress granule | "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule." [GO_REF:0000087, GOC:TermGenie, PMID:24755092] | 3 | 3.263270e-02 | 2 |
| GO:BP | GO:0032071 | regulation of endodeoxyribonuclease activity | "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] | 3 | 3.263270e-02 | 2 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] | 8 | 3.666851e-02 | 2 |
| GO:BP | GO:0033120 | positive regulation of RNA splicing | "Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah] | 5 | 4.146780e-02 | 2 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 20 | 4.237602e-02 | 2 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 31 | 4.509517e-02 | 2 |
| GO:BP | GO:0000470 | maturation of LSU-rRNA | "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators] | 4 | 4.620922e-02 | 2 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0022626 | cytosolic ribosome | "A ribosome located in the cytosol." [GOC:mtg_sensu] | 66 | 2.645643e-116 | 2 |
| GO:CC | GO:0044391 | ribosomal subunit | "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl] | 68 | 3.304799e-102 | 2 |
| GO:CC | GO:0005840 | ribosome | "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] | 70 | 2.215079e-71 | 2 |
| GO:CC | GO:0022625 | cytosolic large ribosomal subunit | "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 34 | 5.316511e-59 | 2 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 104 | 5.639106e-58 | 2 |
| GO:CC | GO:0022627 | cytosolic small ribosomal subunit | "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] | 31 | 1.968098e-57 | 2 |
| GO:CC | GO:0015934 | large ribosomal subunit | "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] | 36 | 7.588795e-49 | 2 |
| GO:CC | GO:0015935 | small ribosomal subunit | "The smaller of the two subunits of a ribosome." [GOC:mah] | 32 | 5.542074e-48 | 2 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 117 | 6.787361e-41 | 2 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 130 | 7.309609e-37 | 2 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 119 | 3.414103e-34 | 2 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 119 | 3.469694e-34 | 2 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 107 | 4.458224e-31 | 2 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 93 | 7.784751e-29 | 2 |
| GO:CC | GO:0032040 | small-subunit processome | "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] | 22 | 2.005229e-28 | 2 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 37 | 3.866154e-28 | 2 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 37 | 9.015954e-28 | 2 |
| GO:CC | GO:0005730 | nucleolus | "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] | 63 | 3.239734e-25 | 2 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 109 | 4.576325e-25 | 2 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 109 | 4.576325e-25 | 2 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 109 | 4.576325e-25 | 2 |
| GO:CC | GO:0030684 | preribosome | "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] | 22 | 2.514985e-24 | 2 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 67 | 5.935125e-24 | 2 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 55 | 4.313223e-22 | 2 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 61 | 5.197916e-22 | 2 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 127 | 5.633724e-22 | 2 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 61 | 1.095168e-21 | 2 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 61 | 1.122470e-21 | 2 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 61 | 1.122470e-21 | 2 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 137 | 5.293289e-20 | 2 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 39 | 1.910139e-18 | 2 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 64 | 4.258991e-14 | 2 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 67 | 1.128110e-11 | 2 |
| GO:CC | GO:0035770 | ribonucleoprotein granule | "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] | 19 | 1.415316e-11 | 2 |
| GO:CC | GO:0005852 | eukaryotic translation initiation factor 3 complex | "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] | 8 | 1.518232e-11 | 2 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 145 | 3.086116e-11 | 2 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 142 | 6.226854e-11 | 2 |
| GO:CC | GO:0014069 | postsynaptic density | "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, PMID:14532281, Wikipedia:Postsynaptic_density] | 20 | 1.295498e-10 | 2 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 67 | 1.639794e-10 | 2 |
| GO:CC | GO:0032279 | asymmetric synapse | "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef] | 20 | 2.915786e-10 | 2 |
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 16 | 3.280850e-10 | 2 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 147 | 3.535510e-10 | 2 |
| GO:CC | GO:0071013 | catalytic step 2 spliceosome | "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 12 | 3.803977e-10 | 2 |
| GO:CC | GO:0036464 | cytoplasmic ribonucleoprotein granule | "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] | 17 | 6.463055e-10 | 2 |
| GO:CC | GO:0099572 | postsynaptic specialization | "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028] | 20 | 8.354689e-10 | 2 |
| GO:CC | GO:0098984 | neuron to neuron synapse | "A synapse in which pre and post-synaptic cells are neurons." [GOC:dos] | 20 | 1.648821e-09 | 2 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 138 | 7.627720e-09 | 2 |
| GO:CC | GO:0035145 | exon-exon junction complex | "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026] | 7 | 2.083919e-08 | 2 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 24 | 1.509233e-07 | 2 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 131 | 1.954858e-07 | 2 |
| GO:CC | GO:0033290 | eukaryotic 48S preinitiation complex | "The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC." [GOC:hjd, PMID:16510876, PMID:24319994, PMID:24499181, PMID:29735639] | 6 | 3.520018e-07 | 2 |
| GO:CC | GO:0016282 | eukaryotic 43S preinitiation complex | "A protein complex composed of the 40S ribosomal subunit plus eIF1, eIF1A, eIF3, eIF5, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049, PMID:16510876, PMID:25742741, PMID:29735639] | 6 | 5.251028e-07 | 2 |
| GO:CC | GO:0070993 | cytosolic translation preinitiation complex | "A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA." [GOC:hjd, GOC:mah] | 6 | 7.632433e-07 | 2 |
| GO:CC | GO:0016607 | nuclear speck | "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640] | 16 | 8.518145e-06 | 2 |
| GO:CC | GO:0005791 | rough endoplasmic reticulum | "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] | 7 | 6.255057e-05 | 2 |
| GO:CC | GO:0071005 | U2-type precatalytic spliceosome | "A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] | 6 | 3.769457e-04 | 2 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 27 | 4.044374e-04 | 2 |
| GO:CC | GO:0071011 | precatalytic spliceosome | "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] | 6 | 7.452248e-04 | 2 |
| GO:CC | GO:0016604 | nuclear body | "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] | 20 | 8.277385e-04 | 2 |
| GO:CC | GO:0005684 | U2-type spliceosomal complex | "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900] | 7 | 1.221280e-03 | 2 |
| GO:CC | GO:0098556 | cytoplasmic side of rough endoplasmic reticulum membrane | "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm." [GOC:ab, GOC:dos] | 3 | 2.166032e-03 | 2 |
| GO:CC | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex | "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits." [PMID:15571813, PMID:15688063] | 3 | 2.166032e-03 | 2 |
| GO:CC | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m | "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185] | 3 | 3.771959e-03 | 2 |
| GO:CC | GO:0110016 | B-WICH complex | "A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself." [GOC:bhm, PMID:16603771, PMID:21559432, PMID:23555303, PMID:26044184] | 3 | 6.005533e-03 | 2 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 28 | 6.314319e-03 | 2 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 7 | 7.602288e-03 | 2 |
| GO:CC | GO:0010494 | cytoplasmic stress granule | "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] | 6 | 1.428358e-02 | 2 |
| GO:CC | GO:0071540 | eukaryotic translation initiation factor 3 complex, eIF3e | "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e." [PMID:15904532, PMID:19061185] | 2 | 1.667281e-02 | 2 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 90 | 2.677801e-02 | 2 |
| GO:CC | GO:0034709 | methylosome | "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452] | 3 | 2.992693e-02 | 2 |
| GO:CC | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex | "A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein." [GOC:bf, GOC:PARL, PMID:12628165] | 2 | 4.979860e-02 | 2 |
| GO:CC | GO:0120259 | 7SK snRNP | "A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb." [PMID:18249148, PMID:28431135] | 2 | 4.979860e-02 | 2 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | L13a-mediated translational silencing of Ceruloplasmin expression | 71 | 3.156114e-114 | 2 |
| REAC | REAC:R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | GTP hydrolysis and joining of the 60S ribosomal subunit | 70 | 2.476415e-111 | 2 |
| REAC | REAC:R-HSA-72689 | Formation of a pool of free 40S subunits | Formation of a pool of free 40S subunits | 68 | 3.373544e-111 | 2 |
| REAC | REAC:R-HSA-72737 | Cap-dependent Translation Initiation | Cap-dependent Translation Initiation | 71 | 5.629675e-111 | 2 |
| REAC | REAC:R-HSA-72613 | Eukaryotic Translation Initiation | Eukaryotic Translation Initiation | 71 | 5.629675e-111 | 2 |
| REAC | REAC:R-HSA-156902 | Peptide chain elongation | Peptide chain elongation | 64 | 6.020390e-107 | 2 |
| REAC | REAC:R-HSA-156842 | Eukaryotic Translation Elongation | Eukaryotic Translation Elongation | 64 | 6.538691e-105 | 2 |
| REAC | REAC:R-HSA-192823 | Viral mRNA Translation | Viral mRNA Translation | 63 | 2.276761e-104 | 2 |
| REAC | REAC:R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 64 | 5.938902e-104 | 2 |
| REAC | REAC:R-HSA-927802 | Nonsense-Mediated Decay (NMD) | Nonsense-Mediated Decay (NMD) | 66 | 1.369623e-100 | 2 |
| REAC | REAC:R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 66 | 1.369623e-100 | 2 |
| REAC | REAC:R-HSA-72764 | Eukaryotic Translation Termination | Eukaryotic Translation Termination | 62 | 6.661414e-100 | 2 |
| REAC | REAC:R-HSA-2408557 | Selenocysteine synthesis | Selenocysteine synthesis | 62 | 6.661414e-100 | 2 |
| REAC | REAC:R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Response of EIF2AK4 (GCN2) to amino acid deficiency | 63 | 7.305159e-99 | 2 |
| REAC | REAC:R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | SRP-dependent cotranslational protein targeting to membrane | 62 | 2.059202e-92 | 2 |
| REAC | REAC:R-HSA-2408522 | Selenoamino acid metabolism | Selenoamino acid metabolism | 62 | 4.365611e-91 | 2 |
| REAC | REAC:R-HSA-168273 | Influenza Viral RNA Transcription and Replication | Influenza Viral RNA Transcription and Replication | 63 | 1.589482e-88 | 2 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 66 | 1.017806e-85 | 2 |
| REAC | REAC:R-HSA-72766 | Translation | Translation | 75 | 1.457093e-83 | 2 |
| REAC | REAC:R-HSA-168255 | Influenza Infection | Influenza Infection | 63 | 2.569511e-83 | 2 |
| REAC | REAC:R-HSA-9711097 | Cellular response to starvation | Cellular response to starvation | 63 | 1.190546e-82 | 2 |
| REAC | REAC:R-HSA-8868773 | rRNA processing in the nucleus and cytosol | rRNA processing in the nucleus and cytosol | 66 | 1.171793e-81 | 2 |
| REAC | REAC:R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Major pathway of rRNA processing in the nucleolus and cytosol | 65 | 1.490591e-81 | 2 |
| REAC | REAC:R-HSA-72312 | rRNA processing | rRNA processing | 66 | 6.457199e-80 | 2 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 66 | 1.701029e-77 | 2 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 89 | 6.614163e-73 | 2 |
| REAC | REAC:R-HSA-72649 | Translation initiation complex formation | Translation initiation complex formation | 38 | 3.561152e-58 | 2 |
| REAC | REAC:R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 38 | 9.631837e-58 | 2 |
| REAC | REAC:R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Formation of the ternary complex, and subsequently, the 43S complex | 36 | 9.958259e-57 | 2 |
| REAC | REAC:R-HSA-72702 | Ribosomal scanning and start codon recognition | Ribosomal scanning and start codon recognition | 37 | 7.104085e-56 | 2 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 62 | 6.042126e-55 | 2 |
| REAC | REAC:R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | SARS-CoV-1 modulates host translation machinery | 30 | 2.033979e-50 | 2 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 67 | 2.136203e-50 | 2 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 67 | 4.554359e-49 | 2 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 74 | 6.700640e-45 | 2 |
| REAC | REAC:R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | SARS-CoV-2 modulates host translation machinery | 30 | 1.994742e-43 | 2 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 68 | 1.663499e-40 | 2 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 68 | 5.267973e-40 | 2 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 75 | 6.246055e-40 | 2 |
| REAC | REAC:R-HSA-9692914 | SARS-CoV-1-host interactions | SARS-CoV-1-host interactions | 31 | 1.084985e-34 | 2 |
| REAC | REAC:R-HSA-9678108 | SARS-CoV-1 Infection | SARS-CoV-1 Infection | 31 | 8.314309e-29 | 2 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 85 | 9.661999e-29 | 2 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 71 | 5.771377e-28 | 2 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 79 | 6.586884e-27 | 2 |
| REAC | REAC:R-HSA-9705683 | SARS-CoV-2-host interactions | SARS-CoV-2-host interactions | 32 | 2.873862e-25 | 2 |
| REAC | REAC:R-HSA-9694516 | SARS-CoV-2 Infection | SARS-CoV-2 Infection | 32 | 8.914316e-20 | 2 |
| REAC | REAC:R-HSA-9679506 | SARS-CoV Infections | SARS-CoV Infections | 36 | 1.264123e-17 | 2 |
| REAC | REAC:R-HSA-1430728 | Metabolism | Metabolism | 65 | 9.088400e-13 | 2 |
| REAC | REAC:R-HSA-72163 | mRNA Splicing - Major Pathway | mRNA Splicing - Major Pathway | 16 | 7.892550e-07 | 2 |
| REAC | REAC:R-HSA-72172 | mRNA Splicing | mRNA Splicing | 16 | 1.296201e-06 | 2 |
| REAC | REAC:R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | Processing of Capped Intron-Containing Pre-mRNA | 17 | 1.073629e-05 | 2 |
| REAC | REAC:R-HSA-6790901 | rRNA modification in the nucleus and cytosol | rRNA modification in the nucleus and cytosol | 8 | 1.720341e-04 | 2 |
| REAC | REAC:R-HSA-9629569 | Protein hydroxylation | Protein hydroxylation | 4 | 3.181391e-02 | 2 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP477 | Cytoplasmic ribosomal proteins | Cytoplasmic ribosomal proteins | 61 | 2.258540e-97 | 2 |
| WP | WP:WP107 | Translation factors | Translation factors | 11 | 1.047397e-08 | 2 |
| WP | WP:WP5027 | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell | 7 | 1.660346e-07 | 2 |
| WP | WP:WP411 | mRNA processing | mRNA processing | 10 | 1.740085e-03 | 2 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03010 | Ribosome | Ribosome | 63 | 1.123212e-85 | 2 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | Coronavirus disease - COVID-19 | 62 | 2.846757e-70 | 2 |
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 14 | 2.105844e-06 | 2 |
| KEGG | KEGG:03015 | mRNA surveillance pathway | mRNA surveillance pathway | 9 | 2.155913e-04 | 2 |
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | Nucleocytoplasmic transport | 7 | 3.071453e-02 | 2 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 125 | 1.049107e-75 | 2 |
| GO:MF | GO:0003735 | structural constituent of ribosome | "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] | 64 | 1.177199e-63 | 2 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 131 | 1.561063e-53 | 2 |
| GO:MF | GO:0005198 | structural molecule activity | "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] | 68 | 2.990475e-43 | 2 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 37 | 6.082013e-28 | 2 |
| GO:MF | GO:0019843 | rRNA binding | "Binding to a ribosomal RNA." [GOC:jl] | 17 | 4.357962e-19 | 2 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 142 | 2.481261e-09 | 2 |
| GO:MF | GO:0180051 | translation factor activity | "A molecular function required for translation of a mRNA into a protein functioning as part of initiation, elongation or termination of translation." [GOC:pg] | 11 | 4.420547e-08 | 2 |
| GO:MF | GO:0003743 | translation initiation factor activity | "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] | 9 | 1.107087e-07 | 2 |
| GO:MF | GO:0048027 | mRNA 5'-UTR binding | "Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid] | 7 | 2.124011e-07 | 2 |
| GO:MF | GO:0055106 | ubiquitin-protein transferase regulator activity | "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl] | 7 | 2.481499e-06 | 2 |
| GO:MF | GO:1990948 | ubiquitin ligase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a ubiquitin ligase." [GOC:dph, GOC:vw, PMID:21389117] | 5 | 3.361044e-06 | 2 |
| GO:MF | GO:0043021 | ribonucleoprotein complex binding | "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] | 12 | 4.139635e-06 | 2 |
| GO:MF | GO:0003727 | single-stranded RNA binding | "Binding to single-stranded RNA." [GOC:jl] | 9 | 8.436468e-06 | 2 |
| GO:MF | GO:0055105 | ubiquitin-protein transferase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase." [GOC:BHF, GOC:rl] | 5 | 2.607886e-05 | 2 |
| GO:MF | GO:0060090 | molecular adaptor activity | "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] | 28 | 3.560573e-05 | 2 |
| GO:MF | GO:0030674 | protein-macromolecule adaptor activity | "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] | 25 | 8.795970e-05 | 2 |
| GO:MF | GO:0003730 | mRNA 3'-UTR binding | "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] | 9 | 1.109919e-04 | 2 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 14 | 1.238802e-04 | 2 |
| GO:MF | GO:0043022 | ribosome binding | "Binding to a ribosome." [GOC:go_curators] | 8 | 1.110863e-03 | 2 |
| GO:MF | GO:0070180 | large ribosomal subunit rRNA binding | "Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh] | 3 | 2.666933e-03 | 2 |
| GO:MF | GO:0097100 | supercoiled DNA binding | "Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA." [GOC:pr, GOC:rph, PMID:20723754, PMID:21345933, Wikipedia:DNA_supercoil] | 3 | 2.666933e-03 | 2 |
| GO:MF | GO:0045182 | translation regulator activity | "Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai] | 6 | 4.259368e-03 | 2 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 25 | 6.756796e-03 | 2 |
| GO:MF | GO:0003725 | double-stranded RNA binding | "Binding to double-stranded RNA." [GOC:jl] | 6 | 1.104148e-02 | 2 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 15 | 1.201678e-02 | 2 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 33 | 1.285675e-02 | 2 |
| GO:MF | GO:0003724 | RNA helicase activity | "Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098] | 6 | 1.392730e-02 | 2 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 147 | 1.587506e-02 | 2 |
| GO:MF | GO:0008186 | ATP-dependent activity, acting on RNA | "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl] | 6 | 1.616796e-02 | 2 |
| GO:MF | GO:0097322 | 7SK snRNA binding | "Binding to a 7SK small nuclear RNA (7SK snRNA)." [GOC:nhn, PMID:21853533] | 3 | 2.192524e-02 | 2 |
| GO:MF | GO:0003697 | single-stranded DNA binding | "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] | 7 | 2.262950e-02 | 2 |
| GO:MF | GO:0008143 | poly(A) binding | "Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl] | 4 | 2.972872e-02 | 2 |
| GO:MF | GO:0008187 | poly-pyrimidine tract binding | "Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl] | 4 | 4.563824e-02 | 2 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:306 | Ribosome, cytoplasmic | Ribosome, cytoplasmic | 56 | 1.955329e-71 | 2 |
| CORUM | CORUM:3055 | Nop56p-associated pre-rRNA complex | Nop56p-associated pre-rRNA complex | 51 | 5.147535e-53 | 2 |
| CORUM | CORUM:305 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 27 | 4.107973e-35 | 2 |
| CORUM | CORUM:338 | 40S ribosomal subunit, cytoplasmic | 40S ribosomal subunit, cytoplasmic | 26 | 1.907390e-34 | 2 |
| CORUM | CORUM:308 | 60S ribosomal subunit, cytoplasmic | 60S ribosomal subunit, cytoplasmic | 29 | 5.101360e-32 | 2 |
| CORUM | CORUM:5380 | TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) | TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) | 12 | 7.963040e-11 | 2 |
| CORUM | CORUM:742 | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) | 6 | 3.281223e-04 | 2 |
| CORUM | CORUM:1097 | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) | eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) | 6 | 5.930072e-04 | 2 |
| CORUM | CORUM:1332 | Large Drosha complex | Large Drosha complex | 6 | 1.107378e-02 | 2 |
| CORUM | CORUM:224 | CAND1-CUL4B-RBX1 complex | CAND1-CUL4B-RBX1 complex | 3 | 1.280866e-02 | 2 |
| CORUM | CORUM:219 | CAND1-CUL1-RBX1 complex | CAND1-CUL1-RBX1 complex | 3 | 1.280866e-02 | 2 |
| CORUM | CORUM:5266 | TNF-alpha/NF-kappa B signaling complex 6 | TNF-alpha/NF-kappa B signaling complex 6 | 5 | 1.372338e-02 | 2 |
| CORUM | CORUM:6838 | IGF2BP1 complex | IGF2BP1 complex | 4 | 4.573362e-02 | 2 |
| CORUM | CORUM:1215 | Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) | Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) | 3 | 4.999547e-02 | 2 |
| CORUM | CORUM:1253 | Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) | Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) | 3 | 4.999547e-02 | 2 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0012133 | Erythroid hypoplasia | Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 18 | 3.597727e-28 | 2 |
| HP | HP:0020118 | Radial artery aplasia | Congenital absence of the radial artery. | 17 | 1.040587e-27 | 2 |
| HP | HP:0031640 | Abnormal radial artery morphology | Any structural anomaly of the radial artery. | 17 | 1.040587e-27 | 2 |
| HP | HP:0030270 | Elevated red cell adenosine deaminase activity | Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine. | 17 | 1.040587e-27 | 2 |
| HP | HP:4000209 | Abnormal erythrocyte adenosine deaminase activity | Activity of adenosine deaminase in red blood cells outside the limits of normal. | 17 | 2.795413e-27 | 2 |
| HP | HP:0005532 | Macrocytic dyserythropoietic anemia | Macrocytic dyserythropoietic anemia | 17 | 7.079696e-27 | 2 |
| HP | HP:0001227 | Abnormality of the thenar eminence | An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb. | 18 | 7.761680e-27 | 2 |
| HP | HP:0011904 | Persistence of hemoglobin F | Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent. | 18 | 2.993533e-26 | 2 |
| HP | HP:0002669 | Osteosarcoma | A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor. | 18 | 2.993533e-26 | 2 |
| HP | HP:0001896 | Reticulocytopenia | A reduced number of reticulocytes in the peripheral blood. | 18 | 2.993533e-26 | 2 |
| HP | HP:0012410 | Pure red cell aplasia | A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction. | 17 | 3.908543e-26 | 2 |
| HP | HP:0001895 | Normochromic anemia | Normochromic anemia | 18 | 1.046000e-25 | 2 |
| HP | HP:0004808 | Acute myeloid leukemia | A form of leukemia characterized by overproduction of an early myeloid cell. | 21 | 5.112330e-25 | 2 |
| HP | HP:0012131 | Abnormal number of erythroid precursors | A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow. | 19 | 6.238939e-25 | 2 |
| HP | HP:0040276 | Adenocarcinoma of the colon | Adenocarcinoma of the colon | 17 | 1.443890e-24 | 2 |
| HP | HP:0006758 | Malignant genitourinary tract tumor | The presence of a malignant neoplasm of the genital system. | 17 | 2.721970e-24 | 2 |
| HP | HP:0040275 | Adenocarcinoma of the large intestine | A malignant epithelial tumor with a glandular organization that originates in the large intestine. | 17 | 1.590963e-23 | 2 |
| HP | HP:0005518 | Increased mean corpuscular volume | Larger than normal size of erythrocytes. | 18 | 6.715904e-23 | 2 |
| HP | HP:0009944 | Partial duplication of thumb phalanx | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 17 | 7.821127e-23 | 2 |
| HP | HP:0040273 | Adenocarcinoma of the intestines | A malignant epithelial tumor with a glandular organization that originates in the intestines. | 17 | 1.286951e-22 | 2 |
| HP | HP:0001894 | Thrombocytosis | Increased numbers of platelets in the peripheral blood. | 19 | 1.322983e-22 | 2 |
| HP | HP:0009999 | Partial duplication of the phalanx of hand | A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones. | 17 | 2.086644e-22 | 2 |
| HP | HP:0009777 | Absent thumb | Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues. | 18 | 6.876307e-22 | 2 |
| HP | HP:0001972 | Macrocytic anemia | A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH). | 19 | 1.576622e-21 | 2 |
| HP | HP:0030272 | Abnormal erythrocyte enzyme concentration or activity | An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme. | 17 | 1.926397e-21 | 2 |
| HP | HP:0025065 | Abnormal mean corpuscular volume | A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters. | 18 | 2.770705e-21 | 2 |
| HP | HP:0002863 | Myelodysplasia | Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia. | 21 | 5.246005e-21 | 2 |
| HP | HP:0000912 | Sprengel anomaly | A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other). | 17 | 1.362590e-20 | 2 |
| HP | HP:0002488 | Acute leukemia | A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts). | 21 | 1.684115e-20 | 2 |
| HP | HP:0000185 | Cleft soft palate | Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency. | 17 | 1.085338e-19 | 2 |
| HP | HP:0009942 | Duplication of thumb phalanx | Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits. | 17 | 1.085338e-19 | 2 |
| HP | HP:0011902 | Abnormal hemoglobin | Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes. | 18 | 2.275750e-19 | 2 |
| HP | HP:0001790 | Nonimmune hydrops fetalis | A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens . | 17 | 6.839834e-19 | 2 |
| HP | HP:0004312 | Abnormal reticulocyte morphology | A reticulocyte abnormality. | 18 | 1.278648e-18 | 2 |
| HP | HP:0001909 | Leukemia | A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. | 22 | 1.793019e-18 | 2 |
| HP | HP:0001199 | Triphalangeal thumb | A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb. | 17 | 2.098500e-18 | 2 |
| HP | HP:0009380 | Finger aplasia | A developmental defect resulting in the presence of fewer than the normal number of fingers (i.e., aplasia of one or more fingers). | 18 | 7.591032e-18 | 2 |
| HP | HP:0001087 | Developmental glaucoma | Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma. | 17 | 7.705477e-18 | 2 |
| HP | HP:0006749 | Malignant gastrointestinal tract tumors | Malignant gastrointestinal tract tumors | 17 | 7.705477e-18 | 2 |
| HP | HP:0002672 | Gastrointestinal carcinoma | Gastrointestinal carcinoma | 17 | 7.705477e-18 | 2 |
| HP | HP:0100273 | Neoplasm of the colon | Neoplasm of the colon | 17 | 4.060163e-17 | 2 |
| HP | HP:0009778 | Short thumb | Hypoplasia (congenital reduction in size) of the thumb. | 19 | 9.132122e-17 | 2 |
| HP | HP:0010622 | Neoplasm of the skeletal system | A tumor (abnormal growth of tissue) of the skeleton. | 18 | 9.712306e-17 | 2 |
| HP | HP:0001875 | Decreased total neutrophil count | Abnormal decrease of absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group. | 22 | 1.438530e-16 | 2 |
| HP | HP:0001882 | Decreased total leukocyte count | An abnormal decreased number of leukocytes in the blood. | 20 | 3.140887e-16 | 2 |
| HP | HP:0011991 | Abnormal total neutrophil count | A deviation from the normal range of neutrophil cell counts in the circulation. | 22 | 9.918326e-16 | 2 |
| HP | HP:0001874 | Abnormality of neutrophils | A neutrophil abnormality. | 23 | 1.538716e-15 | 2 |
| HP | HP:0009601 | Aplasia/Hypoplasia of the thumb | Hypoplastic/small or absent thumb. | 19 | 2.490154e-15 | 2 |
| HP | HP:0001421 | Abnormality of the musculature of the hand | Abnormality of the musculature of the hand | 18 | 4.100450e-15 | 2 |
| HP | HP:0100834 | Neoplasm of the large intestine | The presence of a neoplasm of the large intestine. | 17 | 1.846016e-14 | 2 |
| HP | HP:0000519 | Developmental cataract | A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens. | 18 | 2.818835e-14 | 2 |
| HP | HP:0010972 | Anemia of inadequate production | A kind of anemia characterized by inadequate production of erythrocytes. | 20 | 3.673971e-14 | 2 |
| HP | HP:0032309 | Abnormal granulocyte count | Abnormal increase or decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group. | 22 | 4.366556e-14 | 2 |
| HP | HP:0000465 | Webbed neck | Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline. | 17 | 6.975394e-14 | 2 |
| HP | HP:0001911 | Abnormal granulocyte morphology | Any structural abnormality or abnormal count of granulocytes. | 23 | 7.051859e-14 | 2 |
| HP | HP:0000294 | Low anterior hairline | Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella. | 18 | 7.732888e-14 | 2 |
| HP | HP:0000085 | Horseshoe kidney | A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline. | 18 | 8.735724e-14 | 2 |
| HP | HP:0001789 | Hydrops fetalis | The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema. | 17 | 1.060981e-13 | 2 |
| HP | HP:0001680 | Coarctation of aorta | Coarctation of the aorta is a narrowing or constriction of a segment of the aorta. | 18 | 1.252767e-13 | 2 |
| HP | HP:0000980 | Pallor | Abnormally pale skin. | 18 | 1.410301e-13 | 2 |
| HP | HP:0004377 | Hematological neoplasm | Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). | 22 | 2.542582e-13 | 2 |
| HP | HP:0010974 | Abnormal myeloid leukocyte morphology | An abnormality of myeloid leukocytes. | 23 | 4.430254e-13 | 2 |
| HP | HP:0100242 | Sarcoma | A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant. | 18 | 6.115813e-13 | 2 |
| HP | HP:0001518 | Small for gestational age | Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age. | 21 | 7.449162e-13 | 2 |
| HP | HP:0100736 | Abnormal soft palate morphology | An abnormality of the soft palate. | 21 | 8.671158e-13 | 2 |
| HP | HP:0008772 | Aplasia/Hypoplasia of the external ear | The presence of aplasia or developmental hypoplasia of all or part of the external ear. | 19 | 1.646189e-12 | 2 |
| HP | HP:0008771 | Aplasia/Hypoplasia of the ear | The presence of aplasia or developmental hypoplasia of the ear. | 19 | 3.060203e-12 | 2 |
| HP | HP:0410030 | Cleft lip | A gap in the lip or lips. | 19 | 5.116633e-12 | 2 |
| HP | HP:0008551 | Microtia | Underdevelopment of the external ear. | 18 | 6.775093e-12 | 2 |
| HP | HP:0100542 | Abnormal localization of kidney | An abnormal site of the kidney. | 19 | 2.555886e-11 | 2 |
| HP | HP:0000782 | Abnormal scapula morphology | Any abnormality of the scapula, also known as the shoulder blade. | 17 | 5.135514e-11 | 2 |
| HP | HP:0000599 | Abnormality of the frontal hairline | An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not. | 18 | 6.465272e-11 | 2 |
| HP | HP:0009997 | Duplication of phalanx of hand | This term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated. | 18 | 1.659184e-10 | 2 |
| HP | HP:0004275 | Duplication of hand bones | Duplication of hand bones | 18 | 1.931089e-10 | 2 |
| HP | HP:0009142 | Duplication of bones involving the upper extremities | Duplication of bones involving the upper extremities | 18 | 1.931089e-10 | 2 |
| HP | HP:0009602 | Abnormality of thumb phalanx | A structural anomaly of one or more phalanges of the thumb. | 17 | 3.198634e-10 | 2 |
| HP | HP:0000104 | Renal agenesis | Agenesis, that is, failure of the kidney to develop during embryogenesis and development. | 17 | 4.793732e-10 | 2 |
| HP | HP:0001446 | Abnormality of the musculature of the upper limbs | Abnormality of the musculature of the upper limbs | 19 | 5.175279e-10 | 2 |
| HP | HP:0000286 | Epicanthus | A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus. | 25 | 2.035007e-09 | 2 |
| HP | HP:0000470 | Short neck | Diminished length of the neck. | 21 | 2.258524e-09 | 2 |
| HP | HP:0011893 | Abnormal leukocyte count | Number of leukocytes per volume of blood beyond normal limits. | 23 | 2.439963e-09 | 2 |
| HP | HP:0034058 | Abnormal fetal morphology | Any structural anomaly of the fetus. | 19 | 2.669032e-09 | 2 |
| HP | HP:0007379 | Neoplasm of the genitourinary tract | A tumor (abnormal growth of tissue) of the genitourinary system. | 17 | 2.906161e-09 | 2 |
| HP | HP:0009381 | Short finger | Abnormally short finger associated with developmental hypoplasia. | 19 | 5.560089e-09 | 2 |
| HP | HP:0010720 | Abnormal hair pattern | An abnormality of the distribution of hair growth. | 20 | 6.994995e-09 | 2 |
| HP | HP:0001254 | Lethargy | A state of fatigue, either physical or mental slowness and sluggishness, with difficulties in initiating or performing simple tasks. Distinguished from apathy which implies indifference and a lack of desire or interest in the task. A person with lethargy may have the desire, but not the energy to engage in personal or socially relevant tasks. | 17 | 8.089045e-09 | 2 |
| HP | HP:0009553 | Abnormality of the hairline | The hairline refers to the outline of hair of the head. An abnormality of the hairline can refer to an unusually low or high border between areas of the scalp with and without hair or to abnormal projections of scalp hair. | 18 | 1.375478e-08 | 2 |
| HP | HP:0003319 | Abnormality of the cervical spine | Any abnormality of the cervical vertebral column. | 21 | 1.506018e-08 | 2 |
| HP | HP:0001172 | Abnormal thumb morphology | An abnormal structure of the first digit of the hand. | 20 | 1.926199e-08 | 2 |
| HP | HP:0011873 | Abnormal platelet count | Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood. | 21 | 2.750801e-08 | 2 |
| HP | HP:0011792 | Neoplasm by histology | Neoplasm categorized according to type of histological abnormality. | 19 | 2.820971e-08 | 2 |
| HP | HP:0011875 | Abnormal platelet morphology | An anomaly in platelet form, ultrastructure, or intracellular organelles. | 21 | 3.254820e-08 | 2 |
| HP | HP:0000369 | Low-set ears | Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear. | 26 | 3.356945e-08 | 2 |
| HP | HP:0006265 | Aplasia/Hypoplasia of fingers | Small/hypoplastic or absent/aplastic fingers. | 19 | 5.848971e-08 | 2 |
| HP | HP:0001873 | Thrombocytopenia | A reduction in the number of circulating thrombocytes. | 20 | 6.499094e-08 | 2 |
| HP | HP:0011361 | Congenital abnormal hair pattern | A congenital abnormality of the distribution of hair growth. | 18 | 6.999692e-08 | 2 |
| HP | HP:0007700 | Ocular anterior segment dysgenesis | Abnormal development (dysgenesis) of the anterior segment of the eye globe. These structures are mainly of mesenchymal origin. | 18 | 7.368063e-08 | 2 |
| HP | HP:0001872 | Abnormality of thrombocytes | An abnormality of platelets. | 21 | 9.340317e-08 | 2 |
| HP | HP:0000175 | Cleft palate | Cleft palate is a developmental defect of the palate resulting from a failure of fusion of the palatine processes and manifesting as a separation of the roof of the mouth (soft and hard palate). | 23 | 1.209178e-07 | 2 |
| HP | HP:0007378 | Neoplasm of the gastrointestinal tract | A tumor (abnormal growth of tissue) of the gastrointestinal tract. | 17 | 1.657646e-07 | 2 |
| HP | HP:0100627 | Displacement of the urethral meatus | A displacement of the external urethral orifice from its normal position (in males normally placed at the tip of glans penis, in females normally placed about 2.5 cm behind the glans clitoridis and immediately in front of that of the vagina). | 19 | 2.003864e-07 | 2 |
| HP | HP:0032076 | Abnormal male urethral meatus morphology | Abnormal male urethral meatus morphology | 19 | 2.186838e-07 | 2 |
| HP | HP:0001903 | Anemia | A reduction in erythrocytes volume or hemoglobin concentration. | 23 | 2.669111e-07 | 2 |
| HP | HP:0001881 | Abnormal leukocyte morphology | An abnormality of leukocytes. | 23 | 2.846649e-07 | 2 |
| HP | HP:0010987 | Abnormal cellular immune system morphology | An abnormality of the morphology or counts of the cells that make up the immune system. | 23 | 2.846649e-07 | 2 |
| HP | HP:0008678 | Renal hypoplasia/aplasia | Absence or underdevelopment of the kidney. | 18 | 3.175228e-07 | 2 |
| HP | HP:0034930 | Digestive system neoplasm | A tumor (abnormal growth of tissue) of the digestive system. | 18 | 3.482493e-07 | 2 |
| HP | HP:0009127 | Abnormality of the musculature of the limbs | Abnormality of the musculature of the limbs | 23 | 4.168676e-07 | 2 |
| HP | HP:0000202 | Orofacial cleft | The presence of a cleft (gap, opening, or groove) in the oral cavity, including cleft of the upper lip and/or cleft of the palate. Cleft of the upper lip is visible as a groove or fissure in the lip, most frequently due to a congenital failure of the maxillary and median nasal processes to fuse. Cleft palate is characterized by a grooved depression or fissure in the roof of the mouth, most often resulting from a congenital failure of the palate to fuse properly. Clefts of the lip and palate can occur individually or together. It is preferable to code each defect separately. | 23 | 4.725194e-07 | 2 |
| HP | HP:5201015 | Craniofacial cleft | Congenital abnormality with cleft (gap or opening) in the craniofacial bones. Craniofacial cleft includes facial cleft, orofacial clef, and cleft of the jaw. | 23 | 5.519454e-07 | 2 |
| HP | HP:0032251 | Abnormal immune system morphology | Abnormal immune system morphology | 23 | 6.638542e-07 | 2 |
| HP | HP:0025668 | Abnormal neck morphology | Any structural anomaly of the neck region. | 23 | 7.056803e-07 | 2 |
| HP | HP:0000501 | Glaucoma | Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure. | 18 | 7.142855e-07 | 2 |
| HP | HP:0000047 | Hypospadias | Abnormal position of urethral meatus on the ventral penile shaft (underside) characterized by displacement of the urethral meatus from the tip of the glans penis to the ventral surface of the penis, scrotum, or perineum. | 18 | 8.140776e-07 | 2 |
| HP | HP:0100037 | Abnormality of the scalp hair | An abnormality of the hair of head. | 19 | 9.343860e-07 | 2 |
| HP | HP:0000002 | Abnormality of body height | Deviation from the norm of height with respect to that which is expected according to age and gender norms. | 33 | 1.089392e-06 | 2 |
| HP | HP:0002250 | Abnormal large intestine morphology | Any abnormality of the large intestine. | 19 | 1.277732e-06 | 2 |
| HP | HP:0000159 | Abnormal lip morphology | An abnormality of the lip. | 30 | 1.376512e-06 | 2 |
| HP | HP:0001965 | Abnormal scalp morphology | Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows. | 19 | 1.802863e-06 | 2 |
| HP | HP:0001877 | Abnormal erythrocyte morphology | Any structural abnormality of erythrocytes (red-blood cells). | 23 | 1.822772e-06 | 2 |
| HP | HP:0000252 | Microcephaly | Head circumference below 2 standard deviations below the mean for age and gender. | 31 | 1.894183e-06 | 2 |
| HP | HP:0000431 | Wide nasal bridge | Increased breadth of the nasal bridge (and with it, the nasal root). | 20 | 2.126461e-06 | 2 |
| HP | HP:0040195 | Decreased head circumference | An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean. | 31 | 2.448449e-06 | 2 |
| HP | HP:0001679 | Abnormal aortic morphology | An abnormality of the aorta. | 18 | 2.611487e-06 | 2 |
| HP | HP:0000464 | Abnormality of the neck | An abnormality of the neck. | 23 | 2.955325e-06 | 2 |
| HP | HP:0000795 | Abnormality of the urethra | An abnormality of the urethra, i.e., of the tube which connects the urinary bladder to the outside of the body. | 19 | 3.032239e-06 | 2 |
| HP | HP:0000218 | High palate | Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective). | 24 | 3.585744e-06 | 2 |
| HP | HP:0000357 | Abnormal location of ears | Abnormal location of the ear. | 26 | 4.581340e-06 | 2 |
| HP | HP:0005927 | Aplasia/hypoplasia involving bones of the hand | Absence (due to failure to form) or underdevelopment of the bones of the hand. | 20 | 4.781598e-06 | 2 |
| HP | HP:0004322 | Short stature | A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to \"short stature\" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms). | 31 | 4.814542e-06 | 2 |
| HP | HP:0011927 | Short digit | One or more digit that appears disproportionately short compared to the hand/foot, whereby either the entire digit or a specific phalanx is shortened. | 21 | 7.008669e-06 | 2 |
| HP | HP:0000356 | Abnormality of the outer ear | An abnormality of the external ear. | 30 | 7.032333e-06 | 2 |
| HP | HP:0000036 | Abnormal penis morphology | Abnormality of the male external sex organ. | 22 | 7.779915e-06 | 2 |
| HP | HP:0005280 | Depressed nasal bridge | Posterior positioning of the nasal root in relation to the overall facial profile for age. | 21 | 8.890908e-06 | 2 |
| HP | HP:0000316 | Hypertelorism | Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes). | 24 | 1.067726e-05 | 2 |
| HP | HP:0006496 | Aplasia/hypoplasia involving bones of the upper limbs | Absence (due to failure to form) or underdevelopment of the bones of the upper limbs. | 20 | 1.447535e-05 | 2 |
| HP | HP:0034057 | Fetal anomaly | Structural or functional abnormalities of the fetus. Note that this section comprises terms that describe abnormalities that are specific to the fetus or differ from the corresponding general terms. A term from anywhere in the Human Phenotype Ontology can be applied to a fetus if appropriate. | 20 | 1.634398e-05 | 2 |
| HP | HP:0000032 | Abnormal male external genitalia morphology | Any structural abnormality of male external genitalia. | 27 | 1.887524e-05 | 2 |
| HP | HP:0000492 | Abnormal eyelid morphology | An abnormality of the eyelids. | 30 | 2.658568e-05 | 2 |
| HP | HP:0007364 | Aplasia/Hypoplasia of the cerebrum | Aplasia/Hypoplasia of the cerebrum | 32 | 3.088634e-05 | 2 |
| HP | HP:0000377 | Abnormal pinna morphology | An abnormality of the pinna, which is also referred to as the auricle or external ear. | 29 | 3.199840e-05 | 2 |
| HP | HP:0001631 | Atrial septal defect | Atrial septal defect (ASD) is a congenital abnormality of the interatrial septum that enables blood flow between the left and right atria via the interatrial septum. | 19 | 3.817381e-05 | 2 |
| HP | HP:0011994 | Abnormal atrial septum morphology | An abnormality of the interatrial septum. | 19 | 4.309978e-05 | 2 |
| HP | HP:0005918 | Abnormal finger phalanx morphology | Abnormalities affecting the phalanx of finger. | 21 | 4.615738e-05 | 2 |
| HP | HP:0002060 | Abnormal cerebral morphology | Any structural abnormality of the telencephalon, which is also known as the cerebrum. | 36 | 4.618403e-05 | 2 |
| HP | HP:0000811 | Abnormal external genitalia morphology | A structural anomaly of the external genitalia. | 27 | 4.678479e-05 | 2 |
| HP | HP:0010461 | Abnormality of the male genitalia | Abnormality of the male genital system. | 27 | 5.160497e-05 | 2 |
| HP | HP:0100547 | Abnormal forebrain morphology | An abnormality of the forebrain, which has as its parts the telencephalon, diencephalon, lateral ventricles and third ventricle. | 36 | 7.285634e-05 | 2 |
| HP | HP:0000347 | Micrognathia | Developmental hypoplasia of the mandible. | 23 | 8.089007e-05 | 2 |
| HP | HP:0009118 | Aplasia/Hypoplasia of the mandible | Absence or underdevelopment of the mandible. | 23 | 8.465745e-05 | 2 |
| HP | HP:0001671 | Abnormal cardiac septum morphology | An anomaly of the intra-atrial or intraventricular septum. | 22 | 9.716291e-05 | 2 |
| HP | HP:0009116 | Aplasia/Hypoplasia involving bones of the skull | Aplasia/Hypoplasia involving bones of the skull | 23 | 1.037314e-04 | 2 |
| HP | HP:0025780 | Abnormal volitional state | An abnormality of internal states of motivation or drive that compromise, or interfere with, the ability of the person to attend to basic personal, social, or vocational activities. | 27 | 1.068543e-04 | 2 |
| HP | HP:0001629 | Ventricular septal defect | A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum. | 18 | 1.074292e-04 | 2 |
| HP | HP:0002977 | Aplasia/Hypoplasia involving the central nervous system | Absence or underdevelopment of tissue in the central nervous system. | 34 | 1.247986e-04 | 2 |
| HP | HP:0010936 | Abnormality of the lower urinary tract | An abnormality of the lower urinary tract. | 23 | 1.324929e-04 | 2 |
| HP | HP:0000549 | Abnormal conjugate eye movement | Any deviation from the normal motor coordination of the eyes that allows for bilateral fixation on a single object. | 27 | 1.465608e-04 | 2 |
| HP | HP:0010438 | Abnormal ventricular septum morphology | A structural abnormality of the interventricular septum. | 18 | 1.492574e-04 | 2 |
| HP | HP:0100886 | Abnormality of globe location | An abnormality in the placement of the ocular globe (eyeball). | 26 | 1.747919e-04 | 2 |
| HP | HP:0000745 | Abnormal diminished volition | A reduction in willful and motivated goal-directed behavior that is considered the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action. | 20 | 1.824286e-04 | 2 |
| HP | HP:0005105 | Abnormal nasal morphology | Abnormal nasal morphology | 30 | 1.892513e-04 | 2 |
| HP | HP:0030669 | Abnormal ocular adnexa morphology | A structural anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. | 31 | 1.912566e-04 | 2 |
| HP | HP:0000240 | Abnormality of skull size | Any abnormality of the size of the skull. | 31 | 2.702394e-04 | 2 |
| HP | HP:0032039 | Abnormality of the ocular adnexa | An anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. | 31 | 2.702394e-04 | 2 |
| HP | HP:0045060 | Aplasia/hypoplasia involving bones of the extremities | Aplasia/hypoplasia involving bones of the extremities | 20 | 2.862802e-04 | 2 |
| HP | HP:0011004 | Abnormal systemic arterial morphology | An abnormality of the systemic arterial tree, which consists of the aorta and other systemic arteries. | 18 | 2.891265e-04 | 2 |
| HP | HP:0005120 | Abnormal cardiac atrium morphology | Any structural abnormality of a cardiac atrium. | 19 | 2.991345e-04 | 2 |
| HP | HP:0000174 | Abnormal palate morphology | Any abnormality of the palate, i.e., of roof of the mouth. | 26 | 3.410858e-04 | 2 |
| HP | HP:0000366 | Abnormality of the nose | An abnormality of the nose. | 32 | 3.553564e-04 | 2 |
| HP | HP:0000315 | Abnormality of the orbital region | Abnormality of the orbital region | 31 | 4.095782e-04 | 2 |
| HP | HP:0000925 | Abnormality of the vertebral column | Any abnormality of the vertebral column. | 30 | 4.484493e-04 | 2 |
| HP | HP:0030791 | Abnormal jaw morphology | A structural anomaly of the jaw, the bony structure of the mouth that consists of the mandible and the maxilla. | 26 | 4.887929e-04 | 2 |
| HP | HP:0012443 | Abnormal brain morphology | A structural abnormality of the brain, which has as its parts the forebrain, midbrain, and hindbrain. | 39 | 4.896362e-04 | 2 |
| HP | HP:0031703 | Abnormal ear morphology | Any structural anomaly of the ear. | 31 | 5.217843e-04 | 2 |
| HP | HP:0001510 | Growth delay | A deficiency or slowing down of growth pre- and postnatally. | 33 | 5.372686e-04 | 2 |
| HP | HP:0011793 | Neoplasm by anatomical site | Neoplasm categorized according to the anatomical site of origin of the neoplasm. | 23 | 5.648056e-04 | 2 |
| HP | HP:0000163 | Abnormal oral cavity morphology | Abnormality of the oral cavity, i.e., the opening or hollow part of the mouth. | 36 | 6.890132e-04 | 2 |
| HP | HP:0031816 | Abnormal oral morphology | Any structural anomaly of the mouth, which is also known as the oral cavity. | 36 | 6.890132e-04 | 2 |
| HP | HP:0011821 | Abnormal facial skeleton morphology | An abnormality of one or more of the set of bones that make up the facial skeleton. | 28 | 7.268037e-04 | 2 |
| HP | HP:0009815 | Aplasia/hypoplasia of the extremities | Absence (due to failure to form) or underdevelopment of the extremities. | 20 | 7.927190e-04 | 2 |
| HP | HP:0000277 | Abnormal mandible morphology | Any abnormality of the mandible, the bone of the lower jaw. | 25 | 8.697571e-04 | 2 |
| HP | HP:0009122 | Aplasia/hypoplasia affecting bones of the axial skeleton | Absence (due to failure to form) or underdevelopment of bones of the axial skeleton. | 23 | 8.713796e-04 | 2 |
| HP | HP:0012718 | Abnormal gastrointestinal tract morphology | Abnormal structure of the gastrointestinal tract. | 23 | 8.884491e-04 | 2 |
| HP | HP:0002664 | Neoplasm | An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor). | 23 | 9.235247e-04 | 2 |
| HP | HP:0002011 | Morphological central nervous system abnormality | A structural abnormality of the central nervous system. | 40 | 1.042616e-03 | 2 |
| HP | HP:0001167 | Abnormal finger morphology | An anomaly of a finger. | 26 | 1.067196e-03 | 2 |
| HP | HP:0000518 | Cataract | A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule. | 21 | 1.183375e-03 | 2 |
| HP | HP:0025766 | Abnormal affect | An anomaly in intensity, frequency, or duration of the verbal or behavioral expression of emotions, feelings, or thoughts. | 27 | 1.394743e-03 | 2 |
| HP | HP:0005922 | Abnormal hand morphology | Any structural anomaly of the hand. | 24 | 1.476579e-03 | 2 |
| HP | HP:0002817 | Abnormality of the upper limb | An abnormality of the arm. | 31 | 1.514909e-03 | 2 |
| HP | HP:0002242 | Abnormal intestine morphology | An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine. | 20 | 1.543149e-03 | 2 |
| HP | HP:0000517 | Abnormal lens morphology | An abnormality of the lens. | 21 | 1.647124e-03 | 2 |
| HP | HP:0000508 | Ptosis | The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective). | 20 | 1.718640e-03 | 2 |
| HP | HP:0000486 | Strabismus | A misalignment of the eyes so that the visual axes deviate from bifoveal fixation. The classification of strabismus may be based on a number of features including the relative position of the eyes, whether the deviation is latent or manifest, intermittent or constant, concomitant or otherwise and according to the age of onset and the relevance of any associated refractive error. | 25 | 1.775398e-03 | 2 |
| HP | HP:0011024 | Abnormality of the gastrointestinal tract | An abnormality of the gastrointestinal tract. | 31 | 1.979217e-03 | 2 |
| HP | HP:0000153 | Abnormality of the mouth | An abnormality of the mouth. | 36 | 2.190584e-03 | 2 |
| HP | HP:0012639 | Abnormal nervous system morphology | A structural anomaly of the nervous system. | 40 | 2.757874e-03 | 2 |
| HP | HP:0012243 | Abnormal reproductive system morphology | A structural or developmental anomaly of any of the tissues involved in the genital system. | 27 | 3.243012e-03 | 2 |
| HP | HP:0001713 | Abnormal cardiac ventricle morphology | An abnormality of a cardiac ventricle. | 19 | 3.422289e-03 | 2 |
| HP | HP:0000422 | Abnormal nasal bridge morphology | Abnormality of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi. | 23 | 3.480880e-03 | 2 |
| HP | HP:0001155 | Abnormality of the hand | An abnormality affecting one or both hands. | 29 | 3.486775e-03 | 2 |
| HP | HP:0000290 | Abnormal forehead morphology | An anomaly of the forehead. | 25 | 3.680677e-03 | 2 |
| HP | HP:0025033 | Abnormal digestive system morphology | A structural anomaly of the digestive system. | 23 | 4.003087e-03 | 2 |
| HP | HP:0034684 | Abnormal enzyme concentration or activity | Concentration or activity of an enzyme is above or below the limits of normal. | 19 | 4.414785e-03 | 2 |
| HP | HP:0000929 | Abnormal skull morphology | An abnormality of the skull, the bony framework of the head which is comprised of the neurocranium (with eight cranial bones) and the viscerocranium (facial skeleton) that comprises fourteen facial bones with the mandible as its largest bone. | 36 | 4.863621e-03 | 2 |
| HP | HP:0009121 | Abnormal axial skeleton morphology | An abnormality of the axial skeleton, which comprises the skull, the vertebral column, the ribs and the sternum. | 38 | 6.109616e-03 | 2 |
| HP | HP:0000969 | Edema | An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body. | 18 | 6.957116e-03 | 2 |
| HP | HP:0001595 | Abnormal hair morphology | An abnormality of the hair. | 26 | 7.172226e-03 | 2 |
| HP | HP:0000765 | Abnormal thorax morphology | Any abnormality of the thorax (the region of the body formed by the sternum, the thoracic vertebrae and the ribs). | 21 | 9.322803e-03 | 2 |
| HP | HP:0012758 | Neurodevelopmental delay | Neurodevelopmental delay (NDD) refers to delays in the maturation of the brain and central nervous system; infants and young children with NDD may experience delays in the development of one or more skills including gross motor abilities, fine-motor coordination, language abilities and ability to solve increasingly complex problems. | 36 | 9.659715e-03 | 2 |
| HP | HP:0004325 | Decreased body weight | Abnormally low body weight. | 28 | 1.239667e-02 | 2 |
| HP | HP:0011138 | Abnormal skin adnexa morphology | An abnormality of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands. | 27 | 1.739915e-02 | 2 |
| HP | HP:0000496 | Abnormality of eye movement | An abnormality in voluntary or involuntary eye movements or their control. | 30 | 1.867917e-02 | 2 |
| HP | HP:0009115 | Aplasia/hypoplasia involving the skeleton | Absence (due to failure to form) or underdevelopment of one or more components of the skeleton. | 24 | 2.026391e-02 | 2 |
| HP | HP:0011297 | Abnormal digit morphology | A morphological abnormality of a digit, i.e., of a finger or toe. | 27 | 2.306084e-02 | 2 |
| HP | HP:0030962 | Abnormal morphology of the great vessels | A structural anomaly affecting a blood vessel involved in the circulation of the heart, i.e., the superior or inferior vena cava, the pulmonary arteries, the pulmonary veins, and the aorta. | 18 | 2.624429e-02 | 2 |
| HP | HP:0040068 | Abnormality of limb bone | Abnormality of limb bone | 29 | 2.817715e-02 | 2 |
| HP | HP:0002813 | Abnormal limb bone morphology | Any abnormality of bones of the arms or legs. | 29 | 2.817715e-02 | 2 |
| HP | HP:0000006 | Autosomal dominant inheritance | A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele. | 31 | 2.885693e-02 | 2 |
| HP | HP:0040064 | Abnormality of limbs | Abnormality of limbs | 35 | 3.237858e-02 | 2 |
| HP | HP:0011446 | Abnormality of mental function | Cognitive, psychiatric, or memory anomaly. | 40 | 3.428659e-02 | 2 |
| HP | HP:0011844 | Abnormal appendicular skeleton morphology | An abnormality of the appendicular skeletal system, consisting of the of the limbs, shoulder and pelvic girdles. | 30 | 3.441959e-02 | 2 |
| HP | HP:0012759 | Neurodevelopmental abnormality | A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities. | 38 | 3.745458e-02 | 2 |
| HP | HP:0011032 | Abnormality of fluid regulation | An abnormality of the regulation of body fluids. | 18 | 4.092364e-02 | 2 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 105 | 4.051929e-24 | 2 |
| HPA | HPA:0350473 | Pancreas; exocrine glandular cells[High] | Pancreas; exocrine glandular cells[High] | 75 | 5.678224e-24 | 2 |
| HPA | HPA:0100133 | Cerebral cortex; neuronal cells[High] | Cerebral cortex; neuronal cells[High] | 70 | 2.254404e-21 | 2 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 65 | 3.969493e-20 | 2 |
| HPA | HPA:0630222 | Cervix; squamous epithelial cells[≥Medium] | Cervix; squamous epithelial cells[≥Medium] | 95 | 4.085181e-20 | 2 |
| HPA | HPA:0330222 | Oral mucosa; squamous epithelial cells[≥Medium] | Oral mucosa; squamous epithelial cells[≥Medium] | 101 | 2.428612e-19 | 2 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 107 | 3.698708e-19 | 2 |
| HPA | HPA:0620222 | Vagina; squamous epithelial cells[≥Medium] | Vagina; squamous epithelial cells[≥Medium] | 97 | 8.189831e-19 | 2 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 116 | 4.882015e-18 | 2 |
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 106 | 9.371320e-18 | 2 |
| HPA | HPA:0620221 | Vagina; squamous epithelial cells[≥Low] | Vagina; squamous epithelial cells[≥Low] | 114 | 1.060037e-17 | 2 |
| HPA | HPA:0620000 | Vagina | Vagina | 114 | 1.060037e-17 | 2 |
| HPA | HPA:0330223 | Oral mucosa; squamous epithelial cells[High] | Oral mucosa; squamous epithelial cells[High] | 52 | 1.840769e-17 | 2 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 96 | 2.134341e-17 | 2 |
| HPA | HPA:0250133 | Hippocampus; neuronal cells[High] | Hippocampus; neuronal cells[High] | 54 | 2.432463e-17 | 2 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 79 | 4.355504e-17 | 2 |
| HPA | HPA:0080132 | Caudate; neuronal cells[≥Medium] | Caudate; neuronal cells[≥Medium] | 94 | 6.018925e-16 | 2 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 106 | 7.373088e-16 | 2 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 93 | 1.611162e-15 | 2 |
| HPA | HPA:0090163 | Cerebellum; Purkinje cells[High] | Cerebellum; Purkinje cells[High] | 57 | 2.125058e-15 | 2 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 93 | 2.426286e-15 | 2 |
| HPA | HPA:0420052 | Salivary gland; glandular cells[≥Medium] | Salivary gland; glandular cells[≥Medium] | 101 | 3.378267e-15 | 2 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 95 | 7.283059e-15 | 2 |
| HPA | HPA:0390051 | Prostate; glandular cells[≥Low] | Prostate; glandular cells[≥Low] | 116 | 7.812859e-15 | 2 |
| HPA | HPA:0390000 | Prostate | Prostate | 116 | 7.812859e-15 | 2 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 117 | 9.223921e-15 | 2 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 85 | 1.321106e-14 | 2 |
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 116 | 1.353764e-14 | 2 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 102 | 1.372178e-14 | 2 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 112 | 4.604832e-14 | 2 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 112 | 4.604832e-14 | 2 |
| HPA | HPA:0090191 | Cerebellum; cells in molecular layer[≥Low] | Cerebellum; cells in molecular layer[≥Low] | 95 | 5.287372e-14 | 2 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 117 | 5.322872e-14 | 2 |
| HPA | HPA:0310000 | Lymph node | Lymph node | 114 | 5.814335e-14 | 2 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 111 | 7.298321e-14 | 2 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 51 | 1.016399e-13 | 2 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 109 | 1.234006e-13 | 2 |
| HPA | HPA:0460671 | Skin 1; melanocytes[≥Low] | Skin 1; melanocytes[≥Low] | 103 | 1.362156e-13 | 2 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 101 | 1.638832e-13 | 2 |
| HPA | HPA:0090000 | Cerebellum | Cerebellum | 118 | 2.552442e-13 | 2 |
| HPA | HPA:0620223 | Vagina; squamous epithelial cells[High] | Vagina; squamous epithelial cells[High] | 46 | 4.568684e-13 | 2 |
| HPA | HPA:0080000 | Caudate | Caudate | 116 | 6.647904e-13 | 2 |
| HPA | HPA:0600223 | Tonsil; squamous epithelial cells[High] | Tonsil; squamous epithelial cells[High] | 52 | 7.452690e-13 | 2 |
| HPA | HPA:0420053 | Salivary gland; glandular cells[High] | Salivary gland; glandular cells[High] | 52 | 9.906873e-13 | 2 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 118 | 1.200889e-12 | 2 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 118 | 1.200889e-12 | 2 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 108 | 1.230747e-12 | 2 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 119 | 1.414234e-12 | 2 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 98 | 1.468848e-12 | 2 |
| HPA | HPA:0600433 | Tonsil; germinal center cells[High] | Tonsil; germinal center cells[High] | 47 | 1.617505e-12 | 2 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 116 | 2.547633e-12 | 2 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 97 | 2.852712e-12 | 2 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 87 | 3.194108e-12 | 2 |
| HPA | HPA:0380512 | Placenta; decidual cells[≥Medium] | Placenta; decidual cells[≥Medium] | 82 | 4.025700e-12 | 2 |
| HPA | HPA:0430051 | Seminal vesicle; glandular cells[≥Low] | Seminal vesicle; glandular cells[≥Low] | 114 | 4.920728e-12 | 2 |
| HPA | HPA:0430000 | Seminal vesicle | Seminal vesicle | 114 | 4.920728e-12 | 2 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 121 | 5.166352e-12 | 2 |
| HPA | HPA:0350000 | Pancreas | Pancreas | 118 | 5.569082e-12 | 2 |
| HPA | HPA:0430052 | Seminal vesicle; glandular cells[≥Medium] | Seminal vesicle; glandular cells[≥Medium] | 100 | 6.085924e-12 | 2 |
| HPA | HPA:0130000 | Colon | Colon | 123 | 8.662342e-12 | 2 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 94 | 9.053175e-12 | 2 |
| HPA | HPA:0090161 | Cerebellum; Purkinje cells[≥Low] | Cerebellum; Purkinje cells[≥Low] | 103 | 9.146013e-12 | 2 |
| HPA | HPA:0170252 | Endometrium 2; cells in endometrial stroma[≥Medium] | Endometrium 2; cells in endometrial stroma[≥Medium] | 56 | 1.021914e-11 | 2 |
| HPA | HPA:0040083 | Bone marrow; hematopoietic cells[High] | Bone marrow; hematopoietic cells[High] | 50 | 1.096657e-11 | 2 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 115 | 1.370770e-11 | 2 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 114 | 1.430919e-11 | 2 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 114 | 1.430919e-11 | 2 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 109 | 1.593968e-11 | 2 |
| HPA | HPA:0630000 | Cervix | Cervix | 114 | 1.987210e-11 | 2 |
| HPA | HPA:0080133 | Caudate; neuronal cells[High] | Caudate; neuronal cells[High] | 43 | 2.062844e-11 | 2 |
| HPA | HPA:0290401 | Liver; hepatocytes[≥Low] | Liver; hepatocytes[≥Low] | 104 | 2.461810e-11 | 2 |
| HPA | HPA:0380511 | Placenta; decidual cells[≥Low] | Placenta; decidual cells[≥Low] | 95 | 2.627810e-11 | 2 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 39 | 2.778240e-11 | 2 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 77 | 2.842908e-11 | 2 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 101 | 3.499265e-11 | 2 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 109 | 4.219008e-11 | 2 |
| HPA | HPA:0480000 | Small intestine | Small intestine | 120 | 4.689214e-11 | 2 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 103 | 5.013508e-11 | 2 |
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 39 | 6.376847e-11 | 2 |
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 34 | 6.900722e-11 | 2 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 118 | 9.688035e-11 | 2 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 118 | 9.688035e-11 | 2 |
| HPA | HPA:0290000 | Liver | Liver | 108 | 1.012306e-10 | 2 |
| HPA | HPA:0170053 | Endometrium 2; glandular cells[High] | Endometrium 2; glandular cells[High] | 46 | 1.646140e-10 | 2 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 112 | 1.726228e-10 | 2 |
| HPA | HPA:0400000 | Rectum | Rectum | 120 | 1.777958e-10 | 2 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 111 | 2.641027e-10 | 2 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 40 | 2.658942e-10 | 2 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 33 | 3.200011e-10 | 2 |
| HPA | HPA:0040081 | Bone marrow; hematopoietic cells[≥Low] | Bone marrow; hematopoietic cells[≥Low] | 109 | 3.324164e-10 | 2 |
| HPA | HPA:0040000 | Bone marrow | Bone marrow | 109 | 3.324164e-10 | 2 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 33 | 3.459169e-10 | 2 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 34 | 3.791890e-10 | 2 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 101 | 3.878306e-10 | 2 |
| HPA | HPA:0210053 | Fallopian tube; glandular cells[High] | Fallopian tube; glandular cells[High] | 51 | 4.094454e-10 | 2 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 105 | 4.601095e-10 | 2 |
| HPA | HPA:0210051 | Fallopian tube; glandular cells[≥Low] | Fallopian tube; glandular cells[≥Low] | 102 | 4.809883e-10 | 2 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 60 | 5.117827e-10 | 2 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 67 | 5.970609e-10 | 2 |
| HPA | HPA:0160052 | Endometrium 1; glandular cells[≥Medium] | Endometrium 1; glandular cells[≥Medium] | 96 | 6.348227e-10 | 2 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 112 | 6.665671e-10 | 2 |
| HPA | HPA:0050000 | Breast | Breast | 114 | 7.201220e-10 | 2 |
| HPA | HPA:0190000 | Esophagus | Esophagus | 110 | 7.445059e-10 | 2 |
| HPA | HPA:0190221 | Esophagus; squamous epithelial cells[≥Low] | Esophagus; squamous epithelial cells[≥Low] | 110 | 7.445059e-10 | 2 |
| HPA | HPA:0040082 | Bone marrow; hematopoietic cells[≥Medium] | Bone marrow; hematopoietic cells[≥Medium] | 86 | 9.606503e-10 | 2 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 34 | 1.090046e-09 | 2 |
| HPA | HPA:0600000 | Tonsil | Tonsil | 118 | 1.176342e-09 | 2 |
| HPA | HPA:0380000 | Placenta | Placenta | 116 | 1.524558e-09 | 2 |
| HPA | HPA:0550053 | Stomach 2; glandular cells[High] | Stomach 2; glandular cells[High] | 62 | 1.609106e-09 | 2 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 113 | 1.893081e-09 | 2 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 113 | 1.893081e-09 | 2 |
| HPA | HPA:0340000 | Ovary | Ovary | 98 | 2.000130e-09 | 2 |
| HPA | HPA:0540053 | Stomach 1; glandular cells[High] | Stomach 1; glandular cells[High] | 62 | 2.565820e-09 | 2 |
| HPA | HPA:0250122 | Hippocampus; glial cells[≥Medium] | Hippocampus; glial cells[≥Medium] | 55 | 3.681608e-09 | 2 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 28 | 3.718806e-09 | 2 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 18 | 3.918454e-09 | 2 |
| HPA | HPA:0530000 | Spleen | Spleen | 102 | 4.042586e-09 | 2 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 110 | 4.350698e-09 | 2 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 79 | 4.726168e-09 | 2 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 114 | 5.407247e-09 | 2 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 114 | 5.407247e-09 | 2 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 32 | 6.207987e-09 | 2 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 30 | 7.792048e-09 | 2 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 113 | 8.756036e-09 | 2 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 18 | 9.345535e-09 | 2 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 119 | 9.679789e-09 | 2 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 116 | 1.002466e-08 | 2 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 116 | 1.002466e-08 | 2 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 108 | 1.155039e-08 | 2 |
| HPA | HPA:0100122 | Cerebral cortex; glial cells[≥Medium] | Cerebral cortex; glial cells[≥Medium] | 64 | 1.215477e-08 | 2 |
| HPA | HPA:0300411 | Lung; macrophages[≥Low] | Lung; macrophages[≥Low] | 109 | 1.371332e-08 | 2 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 114 | 1.427002e-08 | 2 |
| HPA | HPA:0030000 | Appendix | Appendix | 117 | 1.491139e-08 | 2 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 114 | 1.561009e-08 | 2 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 99 | 1.573920e-08 | 2 |
| HPA | HPA:0590052 | Thyroid gland; glandular cells[≥Medium] | Thyroid gland; glandular cells[≥Medium] | 98 | 1.755063e-08 | 2 |
| HPA | HPA:0600442 | Tonsil; non-germinal center cells[≥Medium] | Tonsil; non-germinal center cells[≥Medium] | 83 | 1.780722e-08 | 2 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 103 | 1.861322e-08 | 2 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 89 | 2.061919e-08 | 2 |
| HPA | HPA:0380521 | Placenta; trophoblastic cells[≥Low] | Placenta; trophoblastic cells[≥Low] | 105 | 2.238822e-08 | 2 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 29 | 2.329053e-08 | 2 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 64 | 2.352647e-08 | 2 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 54 | 2.499743e-08 | 2 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 112 | 2.655910e-08 | 2 |
| HPA | HPA:0380522 | Placenta; trophoblastic cells[≥Medium] | Placenta; trophoblastic cells[≥Medium] | 92 | 2.754504e-08 | 2 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 33 | 3.025493e-08 | 2 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 98 | 3.848148e-08 | 2 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 32 | 4.072882e-08 | 2 |
| HPA | HPA:0570732 | Testis; Leydig cells[≥Medium] | Testis; Leydig cells[≥Medium] | 95 | 4.303176e-08 | 2 |
| HPA | HPA:0060102 | Bronchus; respiratory epithelial cells[≥Medium] | Bronchus; respiratory epithelial cells[≥Medium] | 90 | 5.439808e-08 | 2 |
| HPA | HPA:0540051 | Stomach 1; glandular cells[≥Low] | Stomach 1; glandular cells[≥Low] | 115 | 6.181733e-08 | 2 |
| HPA | HPA:0540000 | Stomach 1 | Stomach 1 | 115 | 6.181733e-08 | 2 |
| HPA | HPA:0460672 | Skin 1; melanocytes[≥Medium] | Skin 1; melanocytes[≥Medium] | 76 | 6.263927e-08 | 2 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 80 | 6.279937e-08 | 2 |
| HPA | HPA:0570731 | Testis; Leydig cells[≥Low] | Testis; Leydig cells[≥Low] | 111 | 6.530814e-08 | 2 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 30 | 7.055845e-08 | 2 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 33 | 7.596312e-08 | 2 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 18 | 7.872381e-08 | 2 |
| HPA | HPA:0160053 | Endometrium 1; glandular cells[High] | Endometrium 1; glandular cells[High] | 44 | 8.092615e-08 | 2 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 29 | 8.449335e-08 | 2 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 82 | 9.187444e-08 | 2 |
| HPA | HPA:0320103 | Nasopharynx; respiratory epithelial cells[High] | Nasopharynx; respiratory epithelial cells[High] | 49 | 9.844361e-08 | 2 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 35 | 1.113820e-07 | 2 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 33 | 1.150671e-07 | 2 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 26 | 1.390597e-07 | 2 |
| HPA | HPA:0300412 | Lung; macrophages[≥Medium] | Lung; macrophages[≥Medium] | 89 | 1.440461e-07 | 2 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 53 | 1.474677e-07 | 2 |
| HPA | HPA:0470683 | Skin 2; epidermal cells[High] | Skin 2; epidermal cells[High] | 36 | 1.515868e-07 | 2 |
| HPA | HPA:0390052 | Prostate; glandular cells[≥Medium] | Prostate; glandular cells[≥Medium] | 88 | 1.528473e-07 | 2 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 30 | 1.940567e-07 | 2 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 26 | 2.189216e-07 | 2 |
| HPA | HPA:0300000 | Lung | Lung | 112 | 2.210067e-07 | 2 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 26 | 2.447592e-07 | 2 |
| HPA | HPA:0250121 | Hippocampus; glial cells[≥Low] | Hippocampus; glial cells[≥Low] | 80 | 2.714265e-07 | 2 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 17 | 3.728958e-07 | 2 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 27 | 4.204189e-07 | 2 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 32 | 4.390206e-07 | 2 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 27 | 4.502139e-07 | 2 |
| HPA | HPA:0320101 | Nasopharynx; respiratory epithelial cells[≥Low] | Nasopharynx; respiratory epithelial cells[≥Low] | 97 | 4.952943e-07 | 2 |
| HPA | HPA:0220052 | Gallbladder; glandular cells[≥Medium] | Gallbladder; glandular cells[≥Medium] | 105 | 4.979887e-07 | 2 |
| HPA | HPA:0471493 | Skin 2; vascular mural cells[High] | Skin 2; vascular mural cells[High] | 13 | 5.164072e-07 | 2 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 32 | 5.345082e-07 | 2 |
| HPA | HPA:0130201 | Colon; endothelial cells[≥Low] | Colon; endothelial cells[≥Low] | 96 | 5.575595e-07 | 2 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 19 | 5.843188e-07 | 2 |
| HPA | HPA:0100121 | Cerebral cortex; glial cells[≥Low] | Cerebral cortex; glial cells[≥Low] | 88 | 6.721874e-07 | 2 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 21 | 6.738727e-07 | 2 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 99 | 8.419722e-07 | 2 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 38 | 9.262414e-07 | 2 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 33 | 9.730583e-07 | 2 |
| HPA | HPA:0471492 | Skin 2; vascular mural cells[≥Medium] | Skin 2; vascular mural cells[≥Medium] | 15 | 9.774555e-07 | 2 |
| HPA | HPA:0080122 | Caudate; glial cells[≥Medium] | Caudate; glial cells[≥Medium] | 55 | 1.087270e-06 | 2 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 28 | 1.310124e-06 | 2 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 25 | 1.975161e-06 | 2 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 111 | 2.032356e-06 | 2 |
| HPA | HPA:0270000 | Kidney | Kidney | 117 | 2.125684e-06 | 2 |
| HPA | HPA:0360000 | Parathyroid gland | Parathyroid gland | 97 | 2.196402e-06 | 2 |
| HPA | HPA:0360051 | Parathyroid gland; glandular cells[≥Low] | Parathyroid gland; glandular cells[≥Low] | 97 | 2.196402e-06 | 2 |
| HPA | HPA:0050093 | Breast; myoepithelial cells[High] | Breast; myoepithelial cells[High] | 30 | 2.202658e-06 | 2 |
| HPA | HPA:0030052 | Appendix; glandular cells[≥Medium] | Appendix; glandular cells[≥Medium] | 93 | 2.291607e-06 | 2 |
| HPA | HPA:0400052 | Rectum; glandular cells[≥Medium] | Rectum; glandular cells[≥Medium] | 99 | 2.387767e-06 | 2 |
| HPA | HPA:0060103 | Bronchus; respiratory epithelial cells[High] | Bronchus; respiratory epithelial cells[High] | 47 | 2.501438e-06 | 2 |
| HPA | HPA:0060101 | Bronchus; respiratory epithelial cells[≥Low] | Bronchus; respiratory epithelial cells[≥Low] | 97 | 2.668475e-06 | 2 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 27 | 3.015233e-06 | 2 |
| HPA | HPA:0030072 | Appendix; lymphoid tissue[≥Medium] | Appendix; lymphoid tissue[≥Medium] | 63 | 4.429076e-06 | 2 |
| HPA | HPA:0471413 | Skin 2; cells in spinous layer[High] | Skin 2; cells in spinous layer[High] | 16 | 4.493252e-06 | 2 |
| HPA | HPA:0380523 | Placenta; trophoblastic cells[High] | Placenta; trophoblastic cells[High] | 48 | 4.913482e-06 | 2 |
| HPA | HPA:0480052 | Small intestine; glandular cells[≥Medium] | Small intestine; glandular cells[≥Medium] | 98 | 5.005092e-06 | 2 |
| HPA | HPA:0351182 | Pancreas; pancreatic endocrine cells[≥Medium] | Pancreas; pancreatic endocrine cells[≥Medium] | 71 | 5.085133e-06 | 2 |
| HPA | HPA:0380513 | Placenta; decidual cells[High] | Placenta; decidual cells[High] | 36 | 6.588334e-06 | 2 |
| HPA | HPA:0310442 | Lymph node; non-germinal center cells[≥Medium] | Lymph node; non-germinal center cells[≥Medium] | 75 | 7.889846e-06 | 2 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 21 | 8.485648e-06 | 2 |
| HPA | HPA:0080123 | Caudate; glial cells[High] | Caudate; glial cells[High] | 26 | 8.491286e-06 | 2 |
| HPA | HPA:0290402 | Liver; hepatocytes[≥Medium] | Liver; hepatocytes[≥Medium] | 72 | 8.529126e-06 | 2 |
| HPA | HPA:0461493 | Skin 1; vascular mural cells[High] | Skin 1; vascular mural cells[High] | 12 | 9.282834e-06 | 2 |
| HPA | HPA:0470682 | Skin 2; epidermal cells[≥Medium] | Skin 2; epidermal cells[≥Medium] | 75 | 1.030426e-05 | 2 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 16 | 1.204163e-05 | 2 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 74 | 1.209586e-05 | 2 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 74 | 1.209586e-05 | 2 |
| HPA | HPA:0500000 | Soft tissue 1 | Soft tissue 1 | 90 | 1.265644e-05 | 2 |
| HPA | HPA:0270361 | Kidney; cells in tubules[≥Low] | Kidney; cells in tubules[≥Low] | 106 | 1.401914e-05 | 2 |
| HPA | HPA:0570000 | Testis | Testis | 121 | 1.681023e-05 | 2 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 46 | 1.810906e-05 | 2 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 15 | 2.209821e-05 | 2 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 17 | 2.715280e-05 | 2 |
| HPA | HPA:0150051 | Duodenum; glandular cells[≥Low] | Duodenum; glandular cells[≥Low] | 106 | 3.528571e-05 | 2 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 30 | 3.842145e-05 | 2 |
| HPA | HPA:0510651 | Soft tissue 2; fibroblasts[≥Low] | Soft tissue 2; fibroblasts[≥Low] | 75 | 3.980609e-05 | 2 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 58 | 4.065490e-05 | 2 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 23 | 4.101978e-05 | 2 |
| HPA | HPA:0461492 | Skin 1; vascular mural cells[≥Medium] | Skin 1; vascular mural cells[≥Medium] | 13 | 5.136656e-05 | 2 |
| HPA | HPA:0030053 | Appendix; glandular cells[High] | Appendix; glandular cells[High] | 45 | 5.283350e-05 | 2 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 31 | 5.454555e-05 | 2 |
| HPA | HPA:0340463 | Ovary; ovarian stroma cells[High] | Ovary; ovarian stroma cells[High] | 18 | 5.742109e-05 | 2 |
| HPA | HPA:0150052 | Duodenum; glandular cells[≥Medium] | Duodenum; glandular cells[≥Medium] | 96 | 6.566524e-05 | 2 |
| HPA | HPA:0530711 | Spleen; cells in red pulp[≥Low] | Spleen; cells in red pulp[≥Low] | 88 | 7.327461e-05 | 2 |
| HPA | HPA:0460662 | Skin 1; keratinocytes[≥Medium] | Skin 1; keratinocytes[≥Medium] | 64 | 7.453591e-05 | 2 |
| HPA | HPA:0150053 | Duodenum; glandular cells[High] | Duodenum; glandular cells[High] | 55 | 7.592596e-05 | 2 |
| HPA | HPA:0480051 | Small intestine; glandular cells[≥Low] | Small intestine; glandular cells[≥Low] | 105 | 8.438906e-05 | 2 |
| HPA | HPA:0400652 | Rectum; fibroblasts[≥Medium] | Rectum; fibroblasts[≥Medium] | 10 | 9.219736e-05 | 2 |
| HPA | HPA:0570772 | Testis; peritubular cells[≥Medium] | Testis; peritubular cells[≥Medium] | 21 | 9.838600e-05 | 2 |
| HPA | HPA:0130202 | Colon; endothelial cells[≥Medium] | Colon; endothelial cells[≥Medium] | 69 | 1.050665e-04 | 2 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 39 | 1.058861e-04 | 2 |
| HPA | HPA:0130052 | Colon; glandular cells[≥Medium] | Colon; glandular cells[≥Medium] | 94 | 1.464612e-04 | 2 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 23 | 1.465356e-04 | 2 |
| HPA | HPA:0130243 | Colon; peripheral nerve/ganglion[High] | Colon; peripheral nerve/ganglion[High] | 27 | 1.911977e-04 | 2 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 14 | 1.915921e-04 | 2 |
| HPA | HPA:0600443 | Tonsil; non-germinal center cells[High] | Tonsil; non-germinal center cells[High] | 35 | 2.135419e-04 | 2 |
| HPA | HPA:0400051 | Rectum; glandular cells[≥Low] | Rectum; glandular cells[≥Low] | 104 | 2.205741e-04 | 2 |
| HPA | HPA:0240000 | Heart muscle | Heart muscle | 97 | 2.237803e-04 | 2 |
| HPA | HPA:0241101 | Heart muscle; cardiomyocytes[≥Low] | Heart muscle; cardiomyocytes[≥Low] | 97 | 2.237803e-04 | 2 |
| HPA | HPA:0100201 | Cerebral cortex; endothelial cells[≥Low] | Cerebral cortex; endothelial cells[≥Low] | 79 | 2.288715e-04 | 2 |
| HPA | HPA:0180053 | Epididymis; glandular cells[High] | Epididymis; glandular cells[High] | 43 | 2.309757e-04 | 2 |
| HPA | HPA:0400651 | Rectum; fibroblasts[≥Low] | Rectum; fibroblasts[≥Low] | 10 | 2.873779e-04 | 2 |
| HPA | HPA:0471393 | Skin 2; cells in basal layer[High] | Skin 2; cells in basal layer[High] | 15 | 2.954641e-04 | 2 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 85 | 3.153413e-04 | 2 |
| HPA | HPA:0130051 | Colon; glandular cells[≥Low] | Colon; glandular cells[≥Low] | 103 | 3.319168e-04 | 2 |
| HPA | HPA:0220053 | Gallbladder; glandular cells[High] | Gallbladder; glandular cells[High] | 57 | 3.341542e-04 | 2 |
| HPA | HPA:0130242 | Colon; peripheral nerve/ganglion[≥Medium] | Colon; peripheral nerve/ganglion[≥Medium] | 64 | 3.993398e-04 | 2 |
| HPA | HPA:0630053 | Cervix; glandular cells[High] | Cervix; glandular cells[High] | 32 | 4.251812e-04 | 2 |
| HPA | HPA:0400242 | Rectum; peripheral nerve/ganglion[≥Medium] | Rectum; peripheral nerve/ganglion[≥Medium] | 12 | 4.311895e-04 | 2 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 59 | 5.386582e-04 | 2 |
| HPA | HPA:0460641 | Skin 1; Langerhans[≥Low] | Skin 1; Langerhans[≥Low] | 70 | 6.031368e-04 | 2 |
| HPA | HPA:0470673 | Skin 2; melanocytes[High] | Skin 2; melanocytes[High] | 16 | 6.142665e-04 | 2 |
| HPA | HPA:0500653 | Soft tissue 1; fibroblasts[High] | Soft tissue 1; fibroblasts[High] | 20 | 6.200449e-04 | 2 |
| HPA | HPA:0130203 | Colon; endothelial cells[High] | Colon; endothelial cells[High] | 26 | 6.362530e-04 | 2 |
| HPA | HPA:0030051 | Appendix; glandular cells[≥Low] | Appendix; glandular cells[≥Low] | 100 | 6.688120e-04 | 2 |
| HPA | HPA:0351183 | Pancreas; pancreatic endocrine cells[High] | Pancreas; pancreatic endocrine cells[High] | 25 | 6.782384e-04 | 2 |
| HPA | HPA:0570793 | Testis; round or early spermatids[High] | Testis; round or early spermatids[High] | 29 | 7.132790e-04 | 2 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 77 | 7.791113e-04 | 2 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 17 | 7.840672e-04 | 2 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 52 | 8.093026e-04 | 2 |
| HPA | HPA:0400053 | Rectum; glandular cells[High] | Rectum; glandular cells[High] | 52 | 8.706654e-04 | 2 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 36 | 9.029489e-04 | 2 |
| HPA | HPA:0010012 | Adipose tissue; adipocytes[≥Medium] | Adipose tissue; adipocytes[≥Medium] | 47 | 1.149320e-03 | 2 |
| HPA | HPA:0401333 | Rectum; mucosal lymphoid cells[High] | Rectum; mucosal lymphoid cells[High] | 11 | 1.262995e-03 | 2 |
| HPA | HPA:0400243 | Rectum; peripheral nerve/ganglion[High] | Rectum; peripheral nerve/ganglion[High] | 9 | 1.285874e-03 | 2 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 25 | 1.305956e-03 | 2 |
| HPA | HPA:0270362 | Kidney; cells in tubules[≥Medium] | Kidney; cells in tubules[≥Medium] | 90 | 1.312344e-03 | 2 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 14 | 1.368570e-03 | 2 |
| HPA | HPA:0510652 | Soft tissue 2; fibroblasts[≥Medium] | Soft tissue 2; fibroblasts[≥Medium] | 52 | 1.439426e-03 | 2 |
| HPA | HPA:0480053 | Small intestine; glandular cells[High] | Small intestine; glandular cells[High] | 51 | 1.526950e-03 | 2 |
| HPA | HPA:0460642 | Skin 1; Langerhans[≥Medium] | Skin 1; Langerhans[≥Medium] | 52 | 1.716169e-03 | 2 |
| HPA | HPA:0160253 | Endometrium 1; cells in endometrial stroma[High] | Endometrium 1; cells in endometrial stroma[High] | 17 | 1.907167e-03 | 2 |
| HPA | HPA:0270353 | Kidney; cells in glomeruli[High] | Kidney; cells in glomeruli[High] | 25 | 2.024207e-03 | 2 |
| HPA | HPA:0310443 | Lymph node; non-germinal center cells[High] | Lymph node; non-germinal center cells[High] | 31 | 2.117903e-03 | 2 |
| HPA | HPA:0570761 | Testis; pachytene spermatocytes[≥Low] | Testis; pachytene spermatocytes[≥Low] | 48 | 2.363151e-03 | 2 |
| HPA | HPA:0461393 | Skin 1; cells in basal layer[High] | Skin 1; cells in basal layer[High] | 11 | 2.616138e-03 | 2 |
| HPA | HPA:0030892 | Appendix; goblet cells[≥Medium] | Appendix; goblet cells[≥Medium] | 14 | 3.019301e-03 | 2 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 82 | 3.024573e-03 | 2 |
| HPA | HPA:0050012 | Breast; adipocytes[≥Medium] | Breast; adipocytes[≥Medium] | 35 | 3.160640e-03 | 2 |
| HPA | HPA:0440343 | Skeletal muscle; myocytes[High] | Skeletal muscle; myocytes[High] | 25 | 3.212312e-03 | 2 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 18 | 3.645585e-03 | 2 |
| HPA | HPA:0500111 | Soft tissue 1; chondrocytes[≥Low] | Soft tissue 1; chondrocytes[≥Low] | 45 | 3.749220e-03 | 2 |
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 21 | 3.762904e-03 | 2 |
| HPA | HPA:0570792 | Testis; round or early spermatids[≥Medium] | Testis; round or early spermatids[≥Medium] | 41 | 4.126965e-03 | 2 |
| HPA | HPA:0031292 | Appendix; endocrine cells[≥Medium] | Appendix; endocrine cells[≥Medium] | 15 | 4.204557e-03 | 2 |
| HPA | HPA:0570771 | Testis; peritubular cells[≥Low] | Testis; peritubular cells[≥Low] | 22 | 4.479143e-03 | 2 |
| HPA | HPA:0490693 | Smooth muscle; smooth muscle cells[High] | Smooth muscle; smooth muscle cells[High] | 20 | 4.861493e-03 | 2 |
| HPA | HPA:0020053 | Adrenal gland; glandular cells[High] | Adrenal gland; glandular cells[High] | 46 | 5.118733e-03 | 2 |
| HPA | HPA:0510653 | Soft tissue 2; fibroblasts[High] | Soft tissue 2; fibroblasts[High] | 18 | 5.401753e-03 | 2 |
| HPA | HPA:0030443 | Appendix; non-germinal center cells[High] | Appendix; non-germinal center cells[High] | 8 | 5.693149e-03 | 2 |
| HPA | HPA:0390053 | Prostate; glandular cells[High] | Prostate; glandular cells[High] | 32 | 5.731345e-03 | 2 |
| HPA | HPA:0530723 | Spleen; cells in white pulp[High] | Spleen; cells in white pulp[High] | 24 | 5.803790e-03 | 2 |
| HPA | HPA:0510703 | Soft tissue 2; peripheral nerve[High] | Soft tissue 2; peripheral nerve[High] | 13 | 6.658134e-03 | 2 |
| HPA | HPA:0490000 | Smooth muscle | Smooth muscle | 84 | 7.139385e-03 | 2 |
| HPA | HPA:0490691 | Smooth muscle; smooth muscle cells[≥Low] | Smooth muscle; smooth muscle cells[≥Low] | 84 | 7.139385e-03 | 2 |
| HPA | HPA:0570783 | Testis; preleptotene spermatocytes[High] | Testis; preleptotene spermatocytes[High] | 22 | 7.878183e-03 | 2 |
| HPA | HPA:0400892 | Rectum; goblet cells[≥Medium] | Rectum; goblet cells[≥Medium] | 14 | 8.098319e-03 | 2 |
| HPA | HPA:0570762 | Testis; pachytene spermatocytes[≥Medium] | Testis; pachytene spermatocytes[≥Medium] | 40 | 8.449025e-03 | 2 |
| HPA | HPA:0090183 | Cerebellum; cells in granular layer[High] | Cerebellum; cells in granular layer[High] | 22 | 8.543565e-03 | 2 |
| HPA | HPA:0570781 | Testis; preleptotene spermatocytes[≥Low] | Testis; preleptotene spermatocytes[≥Low] | 40 | 8.554777e-03 | 2 |
| HPA | HPA:0570773 | Testis; peritubular cells[High] | Testis; peritubular cells[High] | 11 | 8.624780e-03 | 2 |
| HPA | HPA:0460663 | Skin 1; keratinocytes[High] | Skin 1; keratinocytes[High] | 20 | 9.161606e-03 | 2 |
| HPA | HPA:0030893 | Appendix; goblet cells[High] | Appendix; goblet cells[High] | 10 | 9.183182e-03 | 2 |
| HPA | HPA:0400241 | Rectum; peripheral nerve/ganglion[≥Low] | Rectum; peripheral nerve/ganglion[≥Low] | 12 | 9.436178e-03 | 2 |
| HPA | HPA:0130241 | Colon; peripheral nerve/ganglion[≥Low] | Colon; peripheral nerve/ganglion[≥Low] | 79 | 1.029781e-02 | 2 |
| HPA | HPA:0030073 | Appendix; lymphoid tissue[High] | Appendix; lymphoid tissue[High] | 22 | 1.043412e-02 | 2 |
| HPA | HPA:0131292 | Colon; endocrine cells[≥Medium] | Colon; endocrine cells[≥Medium] | 15 | 1.142009e-02 | 2 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 24 | 1.160648e-02 | 2 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 18 | 1.187913e-02 | 2 |
| HPA | HPA:0050013 | Breast; adipocytes[High] | Breast; adipocytes[High] | 13 | 1.197194e-02 | 2 |
| HPA | HPA:0401292 | Rectum; endocrine cells[≥Medium] | Rectum; endocrine cells[≥Medium] | 15 | 1.243723e-02 | 2 |
| HPA | HPA:0031303 | Appendix; enterocytes[High] | Appendix; enterocytes[High] | 10 | 1.390738e-02 | 2 |
| HPA | HPA:0031302 | Appendix; enterocytes[≥Medium] | Appendix; enterocytes[≥Medium] | 14 | 1.458932e-02 | 2 |
| HPA | HPA:0030071 | Appendix; lymphoid tissue[≥Low] | Appendix; lymphoid tissue[≥Low] | 75 | 1.603086e-02 | 2 |
| HPA | HPA:0131332 | Colon; mucosal lymphoid cells[≥Medium] | Colon; mucosal lymphoid cells[≥Medium] | 14 | 1.642751e-02 | 2 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 16 | 1.747772e-02 | 2 |
| HPA | HPA:0291163 | Liver; cholangiocytes[High] | Liver; cholangiocytes[High] | 13 | 1.767090e-02 | 2 |
| HPA | HPA:0570791 | Testis; round or early spermatids[≥Low] | Testis; round or early spermatids[≥Low] | 45 | 1.849923e-02 | 2 |
| HPA | HPA:0031291 | Appendix; endocrine cells[≥Low] | Appendix; endocrine cells[≥Low] | 15 | 1.881519e-02 | 2 |
| HPA | HPA:0030433 | Appendix; germinal center cells[High] | Appendix; germinal center cells[High] | 7 | 1.893455e-02 | 2 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 71 | 1.928135e-02 | 2 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 22 | 1.963894e-02 | 2 |
| HPA | HPA:0570782 | Testis; preleptotene spermatocytes[≥Medium] | Testis; preleptotene spermatocytes[≥Medium] | 33 | 2.046040e-02 | 2 |
| HPA | HPA:0130053 | Colon; glandular cells[High] | Colon; glandular cells[High] | 46 | 2.196658e-02 | 2 |
| HPA | HPA:0131302 | Colon; enterocytes[≥Medium] | Colon; enterocytes[≥Medium] | 14 | 2.455370e-02 | 2 |
| HPA | HPA:0030441 | Appendix; non-germinal center cells[≥Low] | Appendix; non-germinal center cells[≥Low] | 13 | 2.637899e-02 | 2 |
| HPA | HPA:0150892 | Duodenum; goblet cells[≥Medium] | Duodenum; goblet cells[≥Medium] | 13 | 2.637899e-02 | 2 |
| HPA | HPA:0130892 | Colon; goblet cells[≥Medium] | Colon; goblet cells[≥Medium] | 13 | 2.718116e-02 | 2 |
| HPA | HPA:0030891 | Appendix; goblet cells[≥Low] | Appendix; goblet cells[≥Low] | 14 | 2.820629e-02 | 2 |
| HPA | HPA:0401302 | Rectum; enterocytes[≥Medium] | Rectum; enterocytes[≥Medium] | 14 | 2.979465e-02 | 2 |
| HPA | HPA:0440000 | Skeletal muscle | Skeletal muscle | 87 | 2.990347e-02 | 2 |
| HPA | HPA:0440341 | Skeletal muscle; myocytes[≥Low] | Skeletal muscle; myocytes[≥Low] | 87 | 2.990347e-02 | 2 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 19 | 3.096634e-02 | 2 |
| HPA | HPA:0480892 | Small intestine; goblet cells[≥Medium] | Small intestine; goblet cells[≥Medium] | 13 | 3.151704e-02 | 2 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 47 | 3.526980e-02 | 2 |
| HPA | HPA:0400201 | Rectum; endothelial cells[≥Low] | Rectum; endothelial cells[≥Low] | 11 | 3.564418e-02 | 2 |
| HPA | HPA:0131291 | Colon; endocrine cells[≥Low] | Colon; endocrine cells[≥Low] | 15 | 3.680916e-02 | 2 |
| HPA | HPA:0151292 | Duodenum; endocrine cells[≥Medium] | Duodenum; endocrine cells[≥Medium] | 15 | 3.963225e-02 | 2 |
| HPA | HPA:0401332 | Rectum; mucosal lymphoid cells[≥Medium] | Rectum; mucosal lymphoid cells[≥Medium] | 14 | 4.105998e-02 | 2 |
| HPA | HPA:0401291 | Rectum; endocrine cells[≥Low] | Rectum; endocrine cells[≥Low] | 15 | 4.161747e-02 | 2 |
| HPA | HPA:0131303 | Colon; enterocytes[High] | Colon; enterocytes[High] | 10 | 4.384858e-02 | 2 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 26 | 4.436577e-02 | 2 |
| HPA | HPA:0471453 | Skin 2; hair follicles[High] | Skin 2; hair follicles[High] | 5 | 4.625167e-02 | 2 |
| HPA | HPA:0150891 | Duodenum; goblet cells[≥Low] | Duodenum; goblet cells[≥Low] | 14 | 4.674672e-02 | 2 |
| HPA | HPA:0030442 | Appendix; non-germinal center cells[≥Medium] | Appendix; non-germinal center cells[≥Medium] | 11 | 4.678866e-02 | 2 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 43 | 4.760665e-10 | 2 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 40 | 6.721443e-10 | 2 |
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 33 | 2.684253e-09 | 2 |
| MIRNA | MIRNA:hsa-mir-100-5p | hsa-mir-100-5p | hsa-mir-100-5p | 18 | 2.971470e-09 | 2 |
| MIRNA | MIRNA:hsa-mir-652-3p | hsa-mir-652-3p | hsa-mir-652-3p | 11 | 1.244638e-05 | 2 |
| MIRNA | MIRNA:hsa-mir-186-5p | hsa-mir-186-5p | hsa-mir-186-5p | 22 | 1.831799e-04 | 2 |
| MIRNA | MIRNA:hsa-mir-1296-5p | hsa-mir-1296-5p | hsa-mir-1296-5p | 9 | 5.485211e-04 | 2 |
| MIRNA | MIRNA:hsa-mir-18a-3p | hsa-mir-18a-3p | hsa-mir-18a-3p | 14 | 1.212324e-03 | 2 |
| MIRNA | MIRNA:hsa-mir-149-5p | hsa-mir-149-5p | hsa-mir-149-5p | 14 | 4.416322e-03 | 2 |
| MIRNA | MIRNA:hsa-mir-320a | hsa-mir-320a | hsa-mir-320a | 33 | 6.536961e-03 | 2 |
| MIRNA | MIRNA:hsa-mir-877-3p | hsa-mir-877-3p | hsa-mir-877-3p | 17 | 8.944575e-03 | 2 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 20 | 1.931089e-02 | 2 |
| MIRNA | MIRNA:hsa-mir-92b-3p | hsa-mir-92b-3p | hsa-mir-92b-3p | 17 | 2.587719e-02 | 2 |
| MIRNA | MIRNA:hsa-mir-744-5p | hsa-mir-744-5p | hsa-mir-744-5p | 13 | 3.309578e-02 | 2 |
| MIRNA | MIRNA:hsa-mir-421 | hsa-mir-421 | hsa-mir-421 | 28 | 4.837500e-02 | 2 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M02070 | Factor: TEL1; motif: CNCGGAANNN | Factor: TEL1; motif: CNCGGAANNN | 123 | 1.908583e-09 | 2 |
| TF | TF:M02070_1 | Factor: TEL1; motif: CNCGGAANNN; match class: 1 | Factor: TEL1; motif: CNCGGAANNN; match class: 1 | 77 | 2.960354e-09 | 2 |
| TF | TF:M02065_1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | Factor: ER81; motif: RCCGGAARYN; match class: 1 | 94 | 1.676331e-08 | 2 |
| TF | TF:M02044 | Factor: YY1; motif: GCCGCCATTTTG | Factor: YY1; motif: GCCGCCATTTTG | 86 | 4.884756e-08 | 2 |
| TF | TF:M00025 | Factor: Elk-1; motif: NNNNCCGGAARTNN | Factor: Elk-1; motif: NNNNCCGGAARTNN | 115 | 6.375035e-08 | 2 |
| TF | TF:M04691_1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | Factor: Kaiso; motif: TCTCGCGAG; match class: 1 | 118 | 8.051087e-08 | 2 |
| TF | TF:M00025_1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 | 70 | 8.202241e-08 | 2 |
| TF | TF:M11018_1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 | 146 | 8.897417e-08 | 2 |
| TF | TF:M12600 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN | 105 | 1.097063e-07 | 2 |
| TF | TF:M10436 | Factor: YY1; motif: CAANATGGCGGC | Factor: YY1; motif: CAANATGGCGGC | 101 | 1.660968e-07 | 2 |
| TF | TF:M08982 | Factor: YY1; motif: NAANATGGCGNNN | Factor: YY1; motif: NAANATGGCGNNN | 92 | 2.375420e-07 | 2 |
| TF | TF:M02052 | Factor: EHF; motif: CSCGGAARTN | Factor: EHF; motif: CSCGGAARTN | 114 | 2.964612e-07 | 2 |
| TF | TF:M11447 | Factor: Elf-1; motif: NAMCCGGAAGTN | Factor: Elf-1; motif: NAMCCGGAAGTN | 97 | 3.087144e-07 | 2 |
| TF | TF:M11382_1 | Factor: ESE-1; motif: NWTRCGGAWGCN; match class: 1 | Factor: ESE-1; motif: NWTRCGGAWGCN; match class: 1 | 66 | 3.276313e-07 | 2 |
| TF | TF:M04710_1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | Factor: CHD2; motif: TCTCGCGAG; match class: 1 | 123 | 3.671920e-07 | 2 |
| TF | TF:M11400 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 113 | 3.707312e-07 | 2 |
| TF | TF:M11451 | Factor: Elf-1; motif: NANCCGGAAGTN | Factor: Elf-1; motif: NANCCGGAAGTN | 90 | 5.241818e-07 | 2 |
| TF | TF:M08913 | Factor: FLI-1; motif: NAYTTCCGGT | Factor: FLI-1; motif: NAYTTCCGGT | 101 | 5.569957e-07 | 2 |
| TF | TF:M11400_1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | 66 | 6.290361e-07 | 2 |
| TF | TF:M11392_1 | Factor: Erg; motif: NACCGGAARYN; match class: 1 | Factor: Erg; motif: NACCGGAARYN; match class: 1 | 56 | 8.879758e-07 | 2 |
| TF | TF:M11452 | Factor: Elf-1; motif: NANGCGGAAGTR | Factor: Elf-1; motif: NANGCGGAAGTR | 84 | 1.254492e-06 | 2 |
| TF | TF:M11450 | Factor: Elf-1; motif: NANSCGGAAGTR | Factor: Elf-1; motif: NANSCGGAAGTR | 78 | 1.509230e-06 | 2 |
| TF | TF:M12275 | Factor: YY1; motif: NGCCGCCATYTTGN | Factor: YY1; motif: NGCCGCCATYTTGN | 89 | 1.862342e-06 | 2 |
| TF | TF:M11435 | Factor: Elk-1; motif: NNCCGGAAGTN | Factor: Elk-1; motif: NNCCGGAAGTN | 123 | 2.041085e-06 | 2 |
| TF | TF:M11448 | Factor: Elf-1; motif: NANGCGGAAGTN | Factor: Elf-1; motif: NANGCGGAAGTN | 94 | 2.850812e-06 | 2 |
| TF | TF:M02065 | Factor: ER81; motif: RCCGGAARYN | Factor: ER81; motif: RCCGGAARYN | 129 | 3.214593e-06 | 2 |
| TF | TF:M03977_1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 | 69 | 3.349330e-06 | 2 |
| TF | TF:M11392 | Factor: Erg; motif: NACCGGAARYN | Factor: Erg; motif: NACCGGAARYN | 102 | 3.368317e-06 | 2 |
| TF | TF:M01660_1 | Factor: GABP-alpha; motif: CTTCCK; match class: 1 | Factor: GABP-alpha; motif: CTTCCK; match class: 1 | 73 | 3.633346e-06 | 2 |
| TF | TF:M03975 | Factor: ERG; motif: ACCGGAARTN | Factor: ERG; motif: ACCGGAARTN | 111 | 3.968221e-06 | 2 |
| TF | TF:M04714 | Factor: Elf-1; motif: ACTTCCGGG | Factor: Elf-1; motif: ACTTCCGGG | 95 | 5.216022e-06 | 2 |
| TF | TF:M11396_1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | Factor: Erg; motif: NACCGGAARTN; match class: 1 | 71 | 5.427730e-06 | 2 |
| TF | TF:M11435_1 | Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 | Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 | 78 | 5.735744e-06 | 2 |
| TF | TF:M10104 | Factor: YY1; motif: CAARATGGCGGC | Factor: YY1; motif: CAARATGGCGGC | 80 | 5.991530e-06 | 2 |
| TF | TF:M11396 | Factor: Erg; motif: NACCGGAARTN | Factor: Erg; motif: NACCGGAARTN | 116 | 6.140886e-06 | 2 |
| TF | TF:M02063 | Factor: c-ets-1; motif: ACCGGAWGTN | Factor: c-ets-1; motif: ACCGGAWGTN | 93 | 6.746165e-06 | 2 |
| TF | TF:M01660 | Factor: GABP-alpha; motif: CTTCCK | Factor: GABP-alpha; motif: CTTCCK | 118 | 7.073241e-06 | 2 |
| TF | TF:M02062 | Factor: Erg; motif: ACCGGAAGTN | Factor: Erg; motif: ACCGGAAGTN | 96 | 1.156603e-05 | 2 |
| TF | TF:M01078 | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN | 92 | 1.345309e-05 | 2 |
| TF | TF:M02071 | Factor: ETV7; motif: NCCGGAANNN | Factor: ETV7; motif: NCCGGAANNN | 111 | 1.346746e-05 | 2 |
| TF | TF:M07140 | Factor: Kaiso; motif: NTCTCGCGAGANYTN | Factor: Kaiso; motif: NTCTCGCGAGANYTN | 20 | 1.566016e-05 | 2 |
| TF | TF:M04710 | Factor: CHD2; motif: TCTCGCGAG | Factor: CHD2; motif: TCTCGCGAG | 135 | 1.626237e-05 | 2 |
| TF | TF:M01752_1 | Factor: ERG; motif: ACCGGAART; match class: 1 | Factor: ERG; motif: ACCGGAART; match class: 1 | 58 | 1.812134e-05 | 2 |
| TF | TF:M03975_1 | Factor: ERG; motif: ACCGGAARTN; match class: 1 | Factor: ERG; motif: ACCGGAARTN; match class: 1 | 61 | 1.830606e-05 | 2 |
| TF | TF:M08759_1 | Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 | Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 | 50 | 2.192023e-05 | 2 |
| TF | TF:M02044_1 | Factor: YY1; motif: GCCGCCATTTTG; match class: 1 | Factor: YY1; motif: GCCGCCATTTTG; match class: 1 | 30 | 2.605023e-05 | 2 |
| TF | TF:M03977 | Factor: ETS1; motif: ACCGGAARYN | Factor: ETS1; motif: ACCGGAARYN | 113 | 2.722021e-05 | 2 |
| TF | TF:M09905 | Factor: SAP-1; motif: NNCCGGAAGTGN | Factor: SAP-1; motif: NNCCGGAAGTGN | 97 | 2.783103e-05 | 2 |
| TF | TF:M09607 | Factor: SAP-1; motif: ACCGGAAGTNN | Factor: SAP-1; motif: ACCGGAAGTNN | 67 | 2.852203e-05 | 2 |
| TF | TF:M11018 | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN | 147 | 2.966611e-05 | 2 |
| TF | TF:M11428 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 88 | 3.242936e-05 | 2 |
| TF | TF:M00981 | Factor: CREB,; motif: NTGACGTNA | Factor: CREB,; motif: NTGACGTNA | 97 | 3.424863e-05 | 2 |
| TF | TF:M02059 | Factor: ELK-1; motif: ACCGGAAGTN | Factor: ELK-1; motif: ACCGGAAGTN | 105 | 3.713556e-05 | 2 |
| TF | TF:M00426_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 77 | 3.873821e-05 | 2 |
| TF | TF:M03966 | Factor: ELF1; motif: AACCCGGAAGTR | Factor: ELF1; motif: AACCCGGAAGTR | 83 | 5.180870e-05 | 2 |
| TF | TF:M08526_1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 | 139 | 5.237466e-05 | 2 |
| TF | TF:M04696 | Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN | Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN | 92 | 5.365235e-05 | 2 |
| TF | TF:M04826_1 | Factor: p300; motif: ACNTCCG; match class: 1 | Factor: p300; motif: ACNTCCG; match class: 1 | 140 | 5.530882e-05 | 2 |
| TF | TF:M12599_1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN; match class: 1 | 142 | 5.980692e-05 | 2 |
| TF | TF:M13031_1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | Factor: ETV4; motif: ACCGGAAGTN; match class: 1 | 68 | 6.361703e-05 | 2 |
| TF | TF:M04696_1 | Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN; match class: 1 | Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN; match class: 1 | 38 | 7.179146e-05 | 2 |
| TF | TF:M09606 | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | Factor: nerf; motif: NRRNSCGGAAGNRNNNN | 80 | 7.614034e-05 | 2 |
| TF | TF:M11432_1 | Factor: Elk-1; motif: NACMGGAAGTN; match class: 1 | Factor: Elk-1; motif: NACMGGAAGTN; match class: 1 | 33 | 8.111884e-05 | 2 |
| TF | TF:M09904_1 | Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 | Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 | 47 | 8.174861e-05 | 2 |
| TF | TF:M01035 | Factor: YY1; motif: NYNKCCATNTT | Factor: YY1; motif: NYNKCCATNTT | 76 | 8.199974e-05 | 2 |
| TF | TF:M08913_1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 | 50 | 8.290681e-05 | 2 |
| TF | TF:M08266_1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 | 101 | 8.934670e-05 | 2 |
| TF | TF:M11882_1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 | 118 | 1.035500e-04 | 2 |
| TF | TF:M12273 | Factor: YY1; motif: GGCSGCCATTTTGN | Factor: YY1; motif: GGCSGCCATTTTGN | 78 | 1.389510e-04 | 2 |
| TF | TF:M12238_1 | Factor: DREF; motif: MTRTCGCGAYAK; match class: 1 | Factor: DREF; motif: MTRTCGCGAYAK; match class: 1 | 14 | 1.399106e-04 | 2 |
| TF | TF:M03924_1 | Factor: YY1; motif: NNCGCCATTNN; match class: 1 | Factor: YY1; motif: NNCGCCATTNN; match class: 1 | 56 | 1.407286e-04 | 2 |
| TF | TF:M08875 | Factor: E2F; motif: NNTTTCGCGCN | Factor: E2F; motif: NNTTTCGCGCN | 79 | 1.409821e-04 | 2 |
| TF | TF:M09632_1 | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN; match class: 1 | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN; match class: 1 | 21 | 1.443748e-04 | 2 |
| TF | TF:M03924 | Factor: YY1; motif: NNCGCCATTNN | Factor: YY1; motif: NNCGCCATTNN | 108 | 1.904728e-04 | 2 |
| TF | TF:M03988_1 | Factor: FLI1; motif: ACCGGAARTN; match class: 1 | Factor: FLI1; motif: ACCGGAARTN; match class: 1 | 48 | 1.956552e-04 | 2 |
| TF | TF:M01798 | Factor: RPC155; motif: TCMNGRGTTCRAGWCC | Factor: RPC155; motif: TCMNGRGTTCRAGWCC | 25 | 1.959397e-04 | 2 |
| TF | TF:M03988 | Factor: FLI1; motif: ACCGGAARTN | Factor: FLI1; motif: ACCGGAARTN | 95 | 1.990816e-04 | 2 |
| TF | TF:M02071_1 | Factor: ETV7; motif: NCCGGAANNN; match class: 1 | Factor: ETV7; motif: NCCGGAANNN; match class: 1 | 63 | 2.083803e-04 | 2 |
| TF | TF:M01214 | Factor: ESE-1; motif: NSMGGAARTN | Factor: ESE-1; motif: NSMGGAARTN | 89 | 2.106531e-04 | 2 |
| TF | TF:M02055 | Factor: ESE-1; motif: NSMGGAARTN | Factor: ESE-1; motif: NSMGGAARTN | 89 | 2.106531e-04 | 2 |
| TF | TF:M08223_1 | Factor: Elk-1:OC-2; motif: RCCGGAASCGATCGATNN; match class: 1 | Factor: Elk-1:OC-2; motif: RCCGGAASCGATCGATNN; match class: 1 | 75 | 2.146553e-04 | 2 |
| TF | TF:M09608_1 | Factor: Erg; motif: NNACCGGAARTSN; match class: 1 | Factor: Erg; motif: NNACCGGAARTSN; match class: 1 | 42 | 2.220886e-04 | 2 |
| TF | TF:M00425_1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | Factor: E2F; motif: TTTCGCGC; match class: 1 | 71 | 2.233838e-04 | 2 |
| TF | TF:M00427_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 57 | 2.234530e-04 | 2 |
| TF | TF:M10436_1 | Factor: YY1; motif: CAANATGGCGGC; match class: 1 | Factor: YY1; motif: CAANATGGCGGC; match class: 1 | 41 | 2.424562e-04 | 2 |
| TF | TF:M09600 | Factor: CREB1; motif: TKACGTCAYNN | Factor: CREB1; motif: TKACGTCAYNN | 70 | 2.589506e-04 | 2 |
| TF | TF:M03982 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 83 | 2.779032e-04 | 2 |
| TF | TF:M10880_1 | Factor: Alx-4; motif: NNCRTTAN; match class: 1 | Factor: Alx-4; motif: NNCRTTAN; match class: 1 | 45 | 2.914625e-04 | 2 |
| TF | TF:M00803 | Factor: E2F; motif: GGCGSG | Factor: E2F; motif: GGCGSG | 128 | 2.971068e-04 | 2 |
| TF | TF:M02068 | Factor: etv3; motif: ACCGGAAGYN | Factor: etv3; motif: ACCGGAAGYN | 53 | 2.993883e-04 | 2 |
| TF | TF:M00426 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 120 | 3.056586e-04 | 2 |
| TF | TF:M11382 | Factor: ESE-1; motif: NWTRCGGAWGCN | Factor: ESE-1; motif: NWTRCGGAWGCN | 109 | 3.334929e-04 | 2 |
| TF | TF:M01876 | Factor: GABP-beta; motif: ASMGGAAGKGN | Factor: GABP-beta; motif: ASMGGAAGKGN | 39 | 3.588677e-04 | 2 |
| TF | TF:M11428_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 39 | 3.676097e-04 | 2 |
| TF | TF:M10438_1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | Factor: ZF5; motif: GGSGCGCGS; match class: 1 | 137 | 4.040227e-04 | 2 |
| TF | TF:M04744 | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA | 107 | 4.074835e-04 | 2 |
| TF | TF:M02067 | Factor: ER71; motif: ACCGGAARYN | Factor: ER71; motif: ACCGGAARYN | 75 | 4.332748e-04 | 2 |
| TF | TF:M08982_1 | Factor: YY1; motif: NAANATGGCGNNN; match class: 1 | Factor: YY1; motif: NAANATGGCGNNN; match class: 1 | 33 | 4.718764e-04 | 2 |
| TF | TF:M11425 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 87 | 4.783672e-04 | 2 |
| TF | TF:M11533 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN | 127 | 4.855095e-04 | 2 |
| TF | TF:M11433 | Factor: Elk-1; motif: NRCCGGAAGTN | Factor: Elk-1; motif: NRCCGGAAGTN | 89 | 4.940760e-04 | 2 |
| TF | TF:M08759 | Factor: c-Ets-2; motif: NCCGGAAGTG | Factor: c-Ets-2; motif: NCCGGAAGTG | 94 | 4.949555e-04 | 2 |
| TF | TF:M08298_1 | Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN; match class: 1 | Factor: FOXO1A:Elk-1; motif: RCCGGAWGTTNTN; match class: 1 | 56 | 5.140887e-04 | 2 |
| TF | TF:M02073 | Factor: Fli-1; motif: ACCGGAAGYN | Factor: Fli-1; motif: ACCGGAAGYN | 74 | 5.500013e-04 | 2 |
| TF | TF:M02074 | Factor: GABPalpha; motif: RCCGGAWRYN | Factor: GABPalpha; motif: RCCGGAWRYN | 63 | 5.504327e-04 | 2 |
| TF | TF:M02052_1 | Factor: EHF; motif: CSCGGAARTN; match class: 1 | Factor: EHF; motif: CSCGGAARTN; match class: 1 | 58 | 5.656898e-04 | 2 |
| TF | TF:M00793 | Factor: YY1; motif: GCCATNTTN | Factor: YY1; motif: GCCATNTTN | 62 | 5.692452e-04 | 2 |
| TF | TF:M10438 | Factor: ZF5; motif: GGSGCGCGS | Factor: ZF5; motif: GGSGCGCGS | 143 | 5.725546e-04 | 2 |
| TF | TF:M11427_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 63 | 5.778548e-04 | 2 |
| TF | TF:M10956_1 | Factor: isx; motif: NTCRTTAA; match class: 1 | Factor: isx; motif: NTCRTTAA; match class: 1 | 51 | 5.930055e-04 | 2 |
| TF | TF:M11404 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 97 | 6.064070e-04 | 2 |
| TF | TF:M03970_1 | Factor: ELK1; motif: ACCGGAAGTN; match class: 1 | Factor: ELK1; motif: ACCGGAAGTN; match class: 1 | 26 | 6.265987e-04 | 2 |
| TF | TF:M02059_1 | Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 | Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 | 55 | 6.297672e-04 | 2 |
| TF | TF:M11533_1 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN; match class: 1 | Factor: E2F-1; motif: NTTTTGGCGCCAWWWN; match class: 1 | 97 | 6.302527e-04 | 2 |
| TF | TF:M07140_1 | Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 | Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 | 11 | 6.414738e-04 | 2 |
| TF | TF:M03967 | Factor: ELF3; motif: WACCCGGAAGTAN | Factor: ELF3; motif: WACCCGGAAGTAN | 88 | 6.926875e-04 | 2 |
| TF | TF:M03983 | Factor: ETV5; motif: NCCGGAWGYN | Factor: ETV5; motif: NCCGGAWGYN | 49 | 6.940511e-04 | 2 |
| TF | TF:M11430 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 112 | 7.007383e-04 | 2 |
| TF | TF:M04714_1 | Factor: Elf-1; motif: ACTTCCGGG; match class: 1 | Factor: Elf-1; motif: ACTTCCGGG; match class: 1 | 44 | 7.074402e-04 | 2 |
| TF | TF:M11530 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN | 135 | 7.418756e-04 | 2 |
| TF | TF:M01876_1 | Factor: GABP-beta; motif: ASMGGAAGKGN; match class: 1 | Factor: GABP-beta; motif: ASMGGAAGKGN; match class: 1 | 11 | 7.479457e-04 | 2 |
| TF | TF:M11404_1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | Factor: Fli-1; motif: NACCGGAARTN; match class: 1 | 49 | 7.565940e-04 | 2 |
| TF | TF:M07380 | Factor: E2F-4; motif: NTTTCSCGCC | Factor: E2F-4; motif: NTTTCSCGCC | 126 | 7.616542e-04 | 2 |
| TF | TF:M04744_1 | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 | Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 | 65 | 8.009892e-04 | 2 |
| TF | TF:M09966_1 | Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 | Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 | 16 | 8.610421e-04 | 2 |
| TF | TF:M12557 | Factor: ETV5; motif: NNACTTCCGNN | Factor: ETV5; motif: NNACTTCCGNN | 61 | 8.744563e-04 | 2 |
| TF | TF:M09905_1 | Factor: SAP-1; motif: NNCCGGAAGTGN; match class: 1 | Factor: SAP-1; motif: NNCCGGAAGTGN; match class: 1 | 47 | 9.280241e-04 | 2 |
| TF | TF:M10785 | Factor: hoxa9; motif: RTCGTWANNN | Factor: hoxa9; motif: RTCGTWANNN | 71 | 9.851175e-04 | 2 |
| TF | TF:M00981_1 | Factor: CREB,; motif: NTGACGTNA; match class: 1 | Factor: CREB,; motif: NTGACGTNA; match class: 1 | 46 | 1.019368e-03 | 2 |
| TF | TF:M09904 | Factor: Elk-1; motif: RCCGGAAGTGN | Factor: Elk-1; motif: RCCGGAAGTGN | 92 | 1.038687e-03 | 2 |
| TF | TF:M11430_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 65 | 1.066987e-03 | 2 |
| TF | TF:M03970 | Factor: ELK1; motif: ACCGGAAGTN | Factor: ELK1; motif: ACCGGAAGTN | 64 | 1.070212e-03 | 2 |
| TF | TF:M11424 | Factor: Erm; motif: NNSCGGAWGYN | Factor: Erm; motif: NNSCGGAWGYN | 92 | 1.072534e-03 | 2 |
| TF | TF:M13031 | Factor: ETV4; motif: ACCGGAAGTN | Factor: ETV4; motif: ACCGGAAGTN | 111 | 1.094667e-03 | 2 |
| TF | TF:M11425_1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | Factor: PEA3; motif: NACCGGAAGTN; match class: 1 | 40 | 1.104658e-03 | 2 |
| TF | TF:M12238 | Factor: DREF; motif: MTRTCGCGAYAK | Factor: DREF; motif: MTRTCGCGAYAK | 14 | 1.183386e-03 | 2 |
| TF | TF:M00716 | Factor: ZF5; motif: GSGCGCGR | Factor: ZF5; motif: GSGCGCGR | 142 | 1.212894e-03 | 2 |
| TF | TF:M09901 | Factor: nerf; motif: NNNCCGGAAGTGN | Factor: nerf; motif: NNNCCGGAAGTGN | 69 | 1.278332e-03 | 2 |
| TF | TF:M08526 | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN | 145 | 1.283888e-03 | 2 |
| TF | TF:M11414 | Factor: GABP-alpha; motif: NACCGGAAGTN | Factor: GABP-alpha; motif: NACCGGAAGTN | 46 | 1.290082e-03 | 2 |
| TF | TF:M02053_1 | Factor: ELF1; motif: NCCGGAARTN; match class: 1 | Factor: ELF1; motif: NCCGGAARTN; match class: 1 | 31 | 1.327687e-03 | 2 |
| TF | TF:M11422_1 | Factor: Erm; motif: NRCMGGAAGTN; match class: 1 | Factor: Erm; motif: NRCMGGAAGTN; match class: 1 | 23 | 1.371949e-03 | 2 |
| TF | TF:M09966 | Factor: Kaiso; motif: SARNYCTCGCGAGAN | Factor: Kaiso; motif: SARNYCTCGCGAGAN | 40 | 1.374979e-03 | 2 |
| TF | TF:M11530_1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 | 128 | 1.408991e-03 | 2 |
| TF | TF:M02066 | Factor: PEA3; motif: RCCGGAAGYN | Factor: PEA3; motif: RCCGGAAGYN | 83 | 1.411263e-03 | 2 |
| TF | TF:M01165_1 | Factor: Elk-1; motif: RACCGGAAGTR; match class: 1 | Factor: Elk-1; motif: RACCGGAAGTR; match class: 1 | 38 | 1.418584e-03 | 2 |
| TF | TF:M00940_1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 | 43 | 1.582236e-03 | 2 |
| TF | TF:M11434_1 | Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 | Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 | 46 | 1.627523e-03 | 2 |
| TF | TF:M12599 | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN | Factor: E2F4; motif: YCCCGCCNCNNSSNNSNN | 146 | 2.307271e-03 | 2 |
| TF | TF:M09887 | Factor: CREB1; motif: NRRTGACGTMA | Factor: CREB1; motif: NRRTGACGTMA | 73 | 2.329912e-03 | 2 |
| TF | TF:M11058 | Factor: Hey1; motif: NGCRCGYGYN | Factor: Hey1; motif: NGCRCGYGYN | 117 | 2.336661e-03 | 2 |
| TF | TF:M08307 | Factor: GCMa:Elf-1; motif: NRCCCGCACGGAAGTN | Factor: GCMa:Elf-1; motif: NRCCCGCACGGAAGTN | 98 | 2.414080e-03 | 2 |
| TF | TF:M11066_1 | Factor: HES-7; motif: GNCACGYGNN; match class: 1 | Factor: HES-7; motif: GNCACGYGNN; match class: 1 | 91 | 2.414441e-03 | 2 |
| TF | TF:M11535 | Factor: E2F-4; motif: TTTTGGCGCCAWWN | Factor: E2F-4; motif: TTTTGGCGCCAWWN | 111 | 2.512154e-03 | 2 |
| TF | TF:M11419 | Factor: ER81; motif: NNCCGGAWGYN | Factor: ER81; motif: NNCCGGAWGYN | 74 | 2.627028e-03 | 2 |
| TF | TF:M01163 | Factor: Elk-1; motif: AACCGGAAGTR | Factor: Elk-1; motif: AACCGGAAGTR | 67 | 2.845339e-03 | 2 |
| TF | TF:M03981 | Factor: ETV3; motif: ACCGGAAGTN | Factor: ETV3; motif: ACCGGAAGTN | 39 | 2.901895e-03 | 2 |
| TF | TF:M01167 | Factor: SAP-1a; motif: NACCGGAAGTV | Factor: SAP-1a; motif: NACCGGAAGTV | 35 | 3.166338e-03 | 2 |
| TF | TF:M11420 | Factor: ER81; motif: NACCGGAAGTN | Factor: ER81; motif: NACCGGAAGTN | 48 | 3.292146e-03 | 2 |
| TF | TF:M08205 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT | 133 | 3.363044e-03 | 2 |
| TF | TF:M01078_1 | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 1 | Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 1 | 40 | 3.702637e-03 | 2 |
| TF | TF:M13032_1 | Factor: ETV5; motif: ACCGGAAGTN; match class: 1 | Factor: ETV5; motif: ACCGGAAGTN; match class: 1 | 51 | 3.764819e-03 | 2 |
| TF | TF:M09607_1 | Factor: SAP-1; motif: ACCGGAAGTNN; match class: 1 | Factor: SAP-1; motif: ACCGGAAGTNN; match class: 1 | 23 | 3.809086e-03 | 2 |
| TF | TF:M13032 | Factor: ETV5; motif: ACCGGAAGTN | Factor: ETV5; motif: ACCGGAAGTN | 100 | 3.850868e-03 | 2 |
| TF | TF:M01752 | Factor: ERG; motif: ACCGGAART | Factor: ERG; motif: ACCGGAART | 100 | 3.873728e-03 | 2 |
| TF | TF:M00740_1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 | 61 | 3.874948e-03 | 2 |
| TF | TF:M00327_1 | Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 | Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 | 80 | 4.203312e-03 | 2 |
| TF | TF:M11005_1 | Factor: LHX4; motif: NNCRTTAN; match class: 1 | Factor: LHX4; motif: NNCRTTAN; match class: 1 | 57 | 4.363578e-03 | 2 |
| TF | TF:M01214_1 | Factor: ESE-1; motif: NSMGGAARTN; match class: 1 | Factor: ESE-1; motif: NSMGGAARTN; match class: 1 | 37 | 4.526585e-03 | 2 |
| TF | TF:M02055_1 | Factor: ESE-1; motif: NSMGGAARTN; match class: 1 | Factor: ESE-1; motif: NSMGGAARTN; match class: 1 | 37 | 4.526585e-03 | 2 |
| TF | TF:M12591_1 | Factor: CREB1; motif: NNNNSSGGCGCSSNNNNRTGACGTCAC; match class: 1 | Factor: CREB1; motif: NNNNSSGGCGCSSNNNNRTGACGTCAC; match class: 1 | 99 | 4.571948e-03 | 2 |
| TF | TF:M02053 | Factor: ELF1; motif: NCCGGAARTN | Factor: ELF1; motif: NCCGGAARTN | 73 | 4.784116e-03 | 2 |
| TF | TF:M09608 | Factor: Erg; motif: NNACCGGAARTSN | Factor: Erg; motif: NNACCGGAARTSN | 90 | 5.139853e-03 | 2 |
| TF | TF:M09935 | Factor: GABP-alpha; motif: NNNRCCGGAAGTGN | Factor: GABP-alpha; motif: NNNRCCGGAAGTGN | 59 | 5.171383e-03 | 2 |
| TF | TF:M02061 | Factor: ERF; motif: ACCGGAARYN | Factor: ERF; motif: ACCGGAARYN | 41 | 5.512527e-03 | 2 |
| TF | TF:M11052_1 | Factor: Hey2; motif: NNCACGYGNN; match class: 1 | Factor: Hey2; motif: NNCACGYGNN; match class: 1 | 100 | 6.154243e-03 | 2 |
| TF | TF:M04515 | Factor: E2F-1; motif: WWTGGCGCCAAA | Factor: E2F-1; motif: WWTGGCGCCAAA | 126 | 6.171273e-03 | 2 |
| TF | TF:M12600_1 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN; match class: 1 | Factor: ELF1; motif: NNNASCCGGAAGTGGNNNN; match class: 1 | 47 | 6.552626e-03 | 2 |
| TF | TF:M11447_1 | Factor: Elf-1; motif: NAMCCGGAAGTN; match class: 1 | Factor: Elf-1; motif: NAMCCGGAAGTN; match class: 1 | 41 | 6.627885e-03 | 2 |
| TF | TF:M08917 | Factor: GABP-ALPHA; motif: RCCGGAARTNN | Factor: GABP-ALPHA; motif: RCCGGAARTNN | 42 | 6.642029e-03 | 2 |
| TF | TF:M07234 | Factor: YY1; motif: CAARATGGCNGC | Factor: YY1; motif: CAARATGGCNGC | 72 | 6.699559e-03 | 2 |
| TF | TF:M04698 | Factor: GABP-alpha; motif: CACTTCCGG | Factor: GABP-alpha; motif: CACTTCCGG | 47 | 7.591292e-03 | 2 |
| TF | TF:M08313_1 | Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 | Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 | 101 | 7.660778e-03 | 2 |
| TF | TF:M00938 | Factor: E2F-1; motif: TTGGCGCGRAANNGNM | Factor: E2F-1; motif: TTGGCGCGRAANNGNM | 83 | 8.358368e-03 | 2 |
| TF | TF:M11448_1 | Factor: Elf-1; motif: NANGCGGAAGTN; match class: 1 | Factor: Elf-1; motif: NANGCGGAAGTN; match class: 1 | 38 | 8.367164e-03 | 2 |
| TF | TF:M10885_1 | Factor: PRX-2; motif: NKCGTTAN; match class: 1 | Factor: PRX-2; motif: NKCGTTAN; match class: 1 | 25 | 8.699424e-03 | 2 |
| TF | TF:M11449 | Factor: Elf-1; motif: NANCCGGAAGTN | Factor: Elf-1; motif: NANCCGGAAGTN | 57 | 8.800532e-03 | 2 |
| TF | TF:M11434 | Factor: Elk-1; motif: NRSCGGAAGNN | Factor: Elk-1; motif: NRSCGGAAGNN | 90 | 9.104096e-03 | 2 |
| TF | TF:M08222 | Factor: Elk-1:HOXB13; motif: ACCGGAAGTNGTAAAN | Factor: Elk-1:HOXB13; motif: ACCGGAAGTNGTAAAN | 85 | 9.362717e-03 | 2 |
| TF | TF:M10591_1 | Factor: BSX; motif: NNCGTTAN; match class: 1 | Factor: BSX; motif: NNCGTTAN; match class: 1 | 37 | 9.424711e-03 | 2 |
| TF | TF:M10591 | Factor: BSX; motif: NNCGTTAN | Factor: BSX; motif: NNCGTTAN | 86 | 9.495870e-03 | 2 |
| TF | TF:M11432 | Factor: Elk-1; motif: NACMGGAAGTN | Factor: Elk-1; motif: NACMGGAAGTN | 73 | 9.514288e-03 | 2 |
| TF | TF:M02067_1 | Factor: ER71; motif: ACCGGAARYN; match class: 1 | Factor: ER71; motif: ACCGGAARYN; match class: 1 | 30 | 9.721662e-03 | 2 |
| TF | TF:M10119 | Factor: REX-1; motif: GGCMGCCATTTT | Factor: REX-1; motif: GGCMGCCATTTT | 33 | 9.919454e-03 | 2 |
| TF | TF:M03990_1 | Factor: GABPA; motif: ACCGGAAGTN; match class: 1 | Factor: GABPA; motif: ACCGGAAGTN; match class: 1 | 25 | 1.019760e-02 | 2 |
| TF | TF:M12601 | Factor: ELF4; motif: NCCACTTCCGGNNNN | Factor: ELF4; motif: NCCACTTCCGGNNNN | 69 | 1.047844e-02 | 2 |
| TF | TF:M10625 | Factor: Nkx3-2; motif: NTCGTTAN | Factor: Nkx3-2; motif: NTCGTTAN | 72 | 1.071100e-02 | 2 |
| TF | TF:M11427 | Factor: PEA3; motif: NACCGGAAGTN | Factor: PEA3; motif: NACCGGAAGTN | 107 | 1.128328e-02 | 2 |
| TF | TF:M08229 | Factor: Elk-1:SREBP-2; motif: RTCACGTGACCGGAAGN | Factor: Elk-1:SREBP-2; motif: RTCACGTGACCGGAAGN | 99 | 1.131929e-02 | 2 |
| TF | TF:M09900 | Factor: Elf-1; motif: NNANCCGGAAGTGS | Factor: Elf-1; motif: NNANCCGGAAGTGS | 65 | 1.175412e-02 | 2 |
| TF | TF:M02069 | Factor: Erm; motif: ACCGGAAGTN | Factor: Erm; motif: ACCGGAAGTN | 79 | 1.184429e-02 | 2 |
| TF | TF:M08767 | Factor: HES-1; motif: GNCACGTGNC | Factor: HES-1; motif: GNCACGTGNC | 86 | 1.239677e-02 | 2 |
| TF | TF:M09894 | Factor: E2F-4; motif: SNGGGCGGGAANN | Factor: E2F-4; motif: SNGGGCGGGAANN | 141 | 1.251657e-02 | 2 |
| TF | TF:M00178 | Factor: CREB; motif: NSTGACGTMANN | Factor: CREB; motif: NSTGACGTMANN | 65 | 1.266163e-02 | 2 |
| TF | TF:M11422 | Factor: Erm; motif: NRCMGGAAGTN | Factor: Erm; motif: NRCMGGAAGTN | 60 | 1.327215e-02 | 2 |
| TF | TF:M02073_1 | Factor: Fli-1; motif: ACCGGAAGYN; match class: 1 | Factor: Fli-1; motif: ACCGGAAGYN; match class: 1 | 28 | 1.366107e-02 | 2 |
| TF | TF:M11420_1 | Factor: ER81; motif: NACCGGAAGTN; match class: 1 | Factor: ER81; motif: NACCGGAAGTN; match class: 1 | 15 | 1.411617e-02 | 2 |
| TF | TF:M08767_1 | Factor: HES-1; motif: GNCACGTGNC; match class: 1 | Factor: HES-1; motif: GNCACGTGNC; match class: 1 | 85 | 1.418332e-02 | 2 |
| TF | TF:M00738_1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 | 54 | 1.426509e-02 | 2 |
| TF | TF:M07250 | Factor: E2F-1; motif: NNNSSCGCSAANN | Factor: E2F-1; motif: NNNSSCGCSAANN | 108 | 1.441922e-02 | 2 |
| TF | TF:M02063_1 | Factor: c-ets-1; motif: ACCGGAWGTN; match class: 1 | Factor: c-ets-1; motif: ACCGGAWGTN; match class: 1 | 38 | 1.469670e-02 | 2 |
| TF | TF:M11075 | Factor: Sohlh2; motif: NNCACGTGNN | Factor: Sohlh2; motif: NNCACGTGNN | 115 | 1.646200e-02 | 2 |
| TF | TF:M01163_1 | Factor: Elk-1; motif: AACCGGAAGTR; match class: 1 | Factor: Elk-1; motif: AACCGGAAGTR; match class: 1 | 23 | 1.692608e-02 | 2 |
| TF | TF:M00017 | Factor: ATF; motif: CNSTGACGTNNNYC | Factor: ATF; motif: CNSTGACGTNNNYC | 81 | 1.731154e-02 | 2 |
| TF | TF:M08207_1 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 | 137 | 1.750306e-02 | 2 |
| TF | TF:M00427 | Factor: E2F; motif: TTTSGCGS | Factor: E2F; motif: TTTSGCGS | 99 | 1.914346e-02 | 2 |
| TF | TF:M08286 | Factor: Fli-1:FOXI1; motif: NCCGGATGTTKAY | Factor: Fli-1:FOXI1; motif: NCCGGATGTTKAY | 57 | 1.921353e-02 | 2 |
| TF | TF:M08451 | Factor: Elk-1:HOXA1; motif: ACCGGAAGTAATTA | Factor: Elk-1:HOXA1; motif: ACCGGAAGTAATTA | 90 | 1.960197e-02 | 2 |
| TF | TF:M08423 | Factor: TEF-3:ER81; motif: ACCGGAAATRCC | Factor: TEF-3:ER81; motif: ACCGGAAATRCC | 52 | 1.969360e-02 | 2 |
| TF | TF:M00425 | Factor: E2F; motif: TTTCGCGC | Factor: E2F; motif: TTTCGCGC | 110 | 1.988388e-02 | 2 |
| TF | TF:M10999_1 | Factor: LIM-1; motif: NNCGTTAN; match class: 1 | Factor: LIM-1; motif: NNCGTTAN; match class: 1 | 25 | 2.279835e-02 | 2 |
| TF | TF:M11081_1 | Factor: SREBP-1; motif: RTCRCGTGAY; match class: 1 | Factor: SREBP-1; motif: RTCRCGTGAY; match class: 1 | 86 | 2.317107e-02 | 2 |
| TF | TF:M00177 | Factor: CREB; motif: NSTGACGTAANN | Factor: CREB; motif: NSTGACGTAANN | 64 | 2.321194e-02 | 2 |
| TF | TF:M11883_1 | Factor: pax-6; motif: NYACGCNTSRNYGCNYN; match class: 1 | Factor: pax-6; motif: NYACGCNTSRNYGCNYN; match class: 1 | 85 | 2.361728e-02 | 2 |
| TF | TF:M02069_1 | Factor: Erm; motif: ACCGGAAGTN; match class: 1 | Factor: Erm; motif: ACCGGAAGTN; match class: 1 | 33 | 2.409754e-02 | 2 |
| TF | TF:M03967_1 | Factor: ELF3; motif: WACCCGGAAGTAN; match class: 1 | Factor: ELF3; motif: WACCCGGAAGTAN; match class: 1 | 33 | 2.409754e-02 | 2 |
| TF | TF:M02056 | Factor: ELF4; motif: NCCGGAARTN | Factor: ELF4; motif: NCCGGAARTN | 65 | 2.438190e-02 | 2 |
| TF | TF:M09605 | Factor: Elf-1; motif: NAANCMGGAAGTGN | Factor: Elf-1; motif: NAANCMGGAAGTGN | 69 | 2.450574e-02 | 2 |
| TF | TF:M11881 | Factor: pax-6; motif: NYACGCNTSANYGCNYN | Factor: pax-6; motif: NYACGCNTSANYGCNYN | 123 | 2.695554e-02 | 2 |
| TF | TF:M11415 | Factor: GABP-alpha; motif: NRCCGGAAGTN | Factor: GABP-alpha; motif: NRCCGGAAGTN | 46 | 2.902737e-02 | 2 |
| TF | TF:M08760 | Factor: ETV7; motif: NNSCGGAAGTR | Factor: ETV7; motif: NNSCGGAAGTR | 37 | 2.938234e-02 | 2 |
| TF | TF:M08207 | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT | Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT | 144 | 3.034126e-02 | 2 |
| TF | TF:M08205_1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 | 105 | 3.094983e-02 | 2 |
| TF | TF:M03990 | Factor: GABPA; motif: ACCGGAAGTN | Factor: GABPA; motif: ACCGGAAGTN | 64 | 3.131517e-02 | 2 |
| TF | TF:M08874_1 | Factor: E2F1; motif: NNNNNGCGSSAAAN; match class: 1 | Factor: E2F1; motif: NNNNNGCGSSAAAN; match class: 1 | 35 | 3.143460e-02 | 2 |
| TF | TF:M11379 | Factor: ESE-1; motif: ACCCGGAAGTRNNNNNNNNWWWW | Factor: ESE-1; motif: ACCCGGAAGTRNNNNNNNNWWWW | 45 | 3.223207e-02 | 2 |
| TF | TF:M08451_1 | Factor: Elk-1:HOXA1; motif: ACCGGAAGTAATTA; match class: 1 | Factor: Elk-1:HOXA1; motif: ACCGGAAGTAATTA; match class: 1 | 39 | 3.498052e-02 | 2 |
| TF | TF:M08377_1 | Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 | Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 | 62 | 3.565226e-02 | 2 |
| TF | TF:M07415 | Factor: Elf-1; motif: AWCCCGGAAGTN | Factor: Elf-1; motif: AWCCCGGAAGTN | 86 | 3.595335e-02 | 2 |
| TF | TF:M00916 | Factor: CREB; motif: NNTKACGTCANNNS | Factor: CREB; motif: NNTKACGTCANNNS | 69 | 3.668487e-02 | 2 |
| TF | TF:M00024 | Factor: E2F-1; motif: TWSGCGCGAAAAYKR | Factor: E2F-1; motif: TWSGCGCGAAAAYKR | 93 | 3.729215e-02 | 2 |
| TF | TF:M02072 | Factor: Pet-1; motif: ACCGGAWRTN | Factor: Pet-1; motif: ACCGGAWRTN | 37 | 3.778291e-02 | 2 |
| TF | TF:M09632 | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN | Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN | 43 | 3.930043e-02 | 2 |
| TF | TF:M04518_1 | Factor: E2F-4; motif: AATGGCGCCAAA; match class: 1 | Factor: E2F-4; motif: AATGGCGCCAAA; match class: 1 | 22 | 3.984246e-02 | 2 |
| TF | TF:M11413 | Factor: ER71; motif: NACCGGAARTN | Factor: ER71; motif: NACCGGAARTN | 34 | 4.053248e-02 | 2 |
| TF | TF:M07313 | Factor: ATF-3; motif: SNTGACGYNATN | Factor: ATF-3; motif: SNTGACGYNATN | 42 | 4.278606e-02 | 2 |
| TF | TF:M08341 | Factor: HOXB2:Elk-1; motif: TAATKRCCGGAAGTN | Factor: HOXB2:Elk-1; motif: TAATKRCCGGAAGTN | 71 | 4.295929e-02 | 2 |
| TF | TF:M08875_1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | Factor: E2F; motif: NNTTTCGCGCN; match class: 1 | 30 | 4.322104e-02 | 2 |
| TF | TF:M11528 | Factor: E2F-2; motif: NTTTTGGCGCCAWWWN | Factor: E2F-2; motif: NTTTTGGCGCCAWWWN | 104 | 4.407196e-02 | 2 |
| TF | TF:M11446 | Factor: Elf-1; motif: RANSMGGAAGTR | Factor: Elf-1; motif: RANSMGGAAGTR | 42 | 4.423028e-02 | 2 |
| TF | TF:M11451_1 | Factor: Elf-1; motif: NANCCGGAAGTN; match class: 1 | Factor: Elf-1; motif: NANCCGGAAGTN; match class: 1 | 34 | 4.469120e-02 | 2 |
| TF | TF:M12275_1 | Factor: YY1; motif: NGCCGCCATYTTGN; match class: 1 | Factor: YY1; motif: NGCCGCCATYTTGN; match class: 1 | 28 | 4.484895e-02 | 2 |
| TF | TF:M08232_1 | Factor: Elk-1:TEF; motif: RCCGGAAGTTACGTAAN; match class: 1 | Factor: Elk-1:TEF; motif: RCCGGAAGTTACGTAAN; match class: 1 | 25 | 4.485121e-02 | 2 |
| TF | TF:M02062_1 | Factor: Erg; motif: ACCGGAAGTN; match class: 1 | Factor: Erg; motif: ACCGGAAGTN; match class: 1 | 40 | 4.595438e-02 | 2 |
| TF | TF:M00069 | Factor: YY1; motif: NNNCGGCCATCTTGNCTSNW | Factor: YY1; motif: NNNCGGCCATCTTGNCTSNW | 88 | 4.854046e-02 | 2 |
| TF | TF:M10948_1 | Factor: rax; motif: NNCRTTAN; match class: 1 | Factor: rax; motif: NNCRTTAN; match class: 1 | 63 | 4.914222e-02 | 2 |
| TF | TF:M00430_1 | Factor: E2F-1; motif: NTTSGCGG; match class: 1 | Factor: E2F-1; motif: NTTSGCGG; match class: 1 | 38 | 4.989863e-02 | 2 |
Community 3
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 48 | 2.910592e-47 | 3 |
| GO:CC | GO:0070161 | anchoring junction | "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] | 50 | 8.298226e-39 | 3 |
| GO:CC | GO:0005925 | focal adhesion | "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] | 38 | 4.351150e-36 | 3 |
| GO:CC | GO:0030055 | cell-substrate junction | "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 38 | 1.061994e-35 | 3 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 65 | 1.454113e-33 | 3 |
| GO:CC | GO:0030054 | cell junction | "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] | 60 | 7.653738e-29 | 3 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 56 | 1.308099e-27 | 3 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 56 | 2.714814e-27 | 3 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 56 | 2.781148e-27 | 3 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 56 | 2.781148e-27 | 3 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 43 | 6.709288e-27 | 3 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 43 | 9.099792e-27 | 3 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 45 | 1.171514e-23 | 3 |
| GO:CC | GO:0042641 | actomyosin | "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] | 18 | 4.602390e-22 | 3 |
| GO:CC | GO:0005884 | actin filament | "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] | 19 | 2.145952e-21 | 3 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 65 | 5.349678e-21 | 3 |
| GO:CC | GO:0032432 | actin filament bundle | "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] | 17 | 4.067609e-20 | 3 |
| GO:CC | GO:0030016 | myofibril | "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] | 22 | 6.217521e-20 | 3 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 73 | 1.157937e-19 | 3 |
| GO:CC | GO:0005938 | cell cortex | "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] | 24 | 1.357907e-19 | 3 |
| GO:CC | GO:0043292 | contractile muscle fiber | "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] | 22 | 1.534160e-19 | 3 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 58 | 1.784891e-19 | 3 |
| GO:CC | GO:0001725 | stress fiber | "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] | 16 | 3.964705e-19 | 3 |
| GO:CC | GO:0097517 | contractile actin filament bundle | "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194] | 16 | 3.964705e-19 | 3 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 30 | 2.010588e-16 | 3 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 61 | 2.149749e-16 | 3 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 98 | 1.709645e-15 | 3 |
| GO:CC | GO:0030863 | cortical cytoskeleton | "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] | 15 | 3.250257e-15 | 3 |
| GO:CC | GO:0030017 | sarcomere | "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] | 18 | 3.733764e-15 | 3 |
| GO:CC | GO:0043232 | intracellular membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 73 | 1.204590e-14 | 3 |
| GO:CC | GO:0043228 | membraneless organelle | "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] | 73 | 1.215537e-14 | 3 |
| GO:CC | GO:0031252 | cell leading edge | "The area of a motile cell closest to the direction of movement." [GOC:pg] | 22 | 2.118809e-14 | 3 |
| GO:CC | GO:0005911 | cell-cell junction | "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] | 23 | 1.001247e-13 | 3 |
| GO:CC | GO:0005903 | brush border | "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] | 13 | 1.451427e-12 | 3 |
| GO:CC | GO:0016459 | myosin complex | "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin] | 10 | 4.639486e-11 | 3 |
| GO:CC | GO:0098862 | cluster of actin-based cell projections | "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos] | 13 | 5.020192e-10 | 3 |
| GO:CC | GO:0005865 | striated muscle thin filament | "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] | 7 | 3.028260e-09 | 3 |
| GO:CC | GO:0042995 | cell projection | "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] | 37 | 1.056311e-08 | 3 |
| GO:CC | GO:0036379 | myofilament | "Any of the smallest contractile units of a myofibril (striated muscle fiber)." [Wikipedia:Myofilament] | 7 | 1.080208e-08 | 3 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 37 | 4.024082e-08 | 3 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 37 | 4.305441e-08 | 3 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 24 | 6.390400e-08 | 3 |
| GO:CC | GO:0001533 | cornified envelope | "A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes)." [GOC:add, PMID:11112355, PMID:11590230, PMID:15803139] | 8 | 1.204495e-07 | 3 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 102 | 1.232248e-07 | 3 |
| GO:CC | GO:0005862 | muscle thin filament tropomyosin | "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194] | 4 | 1.470072e-07 | 3 |
| GO:CC | GO:0071944 | cell periphery | "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] | 60 | 1.806870e-07 | 3 |
| GO:CC | GO:0120025 | plasma membrane bounded cell projection | "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] | 34 | 2.317903e-07 | 3 |
| GO:CC | GO:0002102 | podosome | "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] | 7 | 2.591646e-07 | 3 |
| GO:CC | GO:0005912 | adherens junction | "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264] | 11 | 4.678301e-07 | 3 |
| GO:CC | GO:0016460 | myosin II complex | "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin] | 6 | 8.111461e-07 | 3 |
| GO:CC | GO:0030864 | cortical actin cytoskeleton | "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] | 8 | 2.057138e-06 | 3 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 20 | 2.253095e-06 | 3 |
| GO:CC | GO:0031941 | filamentous actin | "A two-stranded helical polymer of the protein actin." [GOC:mah] | 6 | 2.966666e-06 | 3 |
| GO:CC | GO:0030018 | Z disc | "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] | 9 | 3.932723e-06 | 3 |
| GO:CC | GO:0001726 | ruffle | "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] | 10 | 5.217789e-06 | 3 |
| GO:CC | GO:0005886 | plasma membrane | "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] | 54 | 9.252430e-06 | 3 |
| GO:CC | GO:0031674 | I band | "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131] | 9 | 1.006422e-05 | 3 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 12 | 1.260780e-05 | 3 |
| GO:CC | GO:0098590 | plasma membrane region | "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] | 23 | 1.375871e-05 | 3 |
| GO:CC | GO:0030027 | lamellipodium | "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194] | 10 | 1.389127e-05 | 3 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 12 | 1.491730e-05 | 3 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 12 | 1.542228e-05 | 3 |
| GO:CC | GO:0005916 | fascia adherens | "A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:aruk, GOC:bc, GOC:mtg_muscle, PMID:11732910] | 4 | 1.819082e-05 | 3 |
| GO:CC | GO:0044291 | cell-cell contact zone | "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018] | 7 | 2.203526e-05 | 3 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 102 | 3.027388e-05 | 3 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 97 | 4.132287e-05 | 3 |
| GO:CC | GO:0098978 | glutamatergic synapse | "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] | 15 | 4.503104e-05 | 3 |
| GO:CC | GO:0014704 | intercalated disc | "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910] | 6 | 5.699797e-05 | 3 |
| GO:CC | GO:0030057 | desmosome | "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181] | 5 | 8.617947e-05 | 3 |
| GO:CC | GO:0030424 | axon | "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] | 15 | 1.427381e-04 | 3 |
| GO:CC | GO:0016020 | membrane | "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] | 72 | 1.471407e-04 | 3 |
| GO:CC | GO:0045202 | synapse | "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] | 24 | 1.879302e-04 | 3 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 22 | 2.228274e-04 | 3 |
| GO:CC | GO:0043034 | costamere | "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378] | 4 | 4.276337e-04 | 3 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 8 | 8.148965e-04 | 3 |
| GO:CC | GO:0150034 | distal axon | "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] | 9 | 2.303701e-03 | 3 |
| GO:CC | GO:0005902 | microvillus | "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194] | 6 | 2.336969e-03 | 3 |
| GO:CC | GO:0031253 | cell projection membrane | "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah] | 10 | 2.452363e-03 | 3 |
| GO:CC | GO:0016461 | unconventional myosin complex | "A portmanteau term for myosins other than myosin II." [GOC:ma] | 3 | 2.652577e-03 | 3 |
| GO:CC | GO:0043296 | apical junction complex | "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556] | 7 | 2.768309e-03 | 3 |
| GO:CC | GO:0098858 | actin-based cell projection | "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519] | 8 | 4.468580e-03 | 3 |
| GO:CC | GO:0030426 | growth cone | "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] | 7 | 4.678830e-03 | 3 |
| GO:CC | GO:0005885 | Arp2/3 protein complex | "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800] | 3 | 5.174880e-03 | 3 |
| GO:CC | GO:0048770 | pigment granule | "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] | 6 | 5.255194e-03 | 3 |
| GO:CC | GO:0042470 | melanosome | "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] | 6 | 5.255194e-03 | 3 |
| GO:CC | GO:0030427 | site of polarized growth | "Any part of a cell where non-isotropic growth takes place." [GOC:mah] | 7 | 5.657177e-03 | 3 |
| GO:CC | GO:0008180 | COP9 signalosome | "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] | 4 | 6.881737e-03 | 3 |
| GO:CC | GO:0012505 | endomembrane system | "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] | 41 | 1.408385e-02 | 3 |
| GO:CC | GO:0072562 | blood microparticle | "A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids." [GOC:BHF, GOC:mah, PMID:16373184] | 6 | 1.609868e-02 | 3 |
| GO:CC | GO:0043005 | neuron projection | "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] | 18 | 1.795594e-02 | 3 |
| GO:CC | GO:0097513 | myosin II filament | "A bipolar filament composed of myosin II molecules." [GOC:cjm, GOC:mah] | 2 | 2.093211e-02 | 3 |
| GO:CC | GO:0035578 | azurophil granule lumen | "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] | 5 | 2.241660e-02 | 3 |
| GO:CC | GO:0098794 | postsynapse | "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] | 13 | 2.342839e-02 | 3 |
| GO:CC | GO:0045177 | apical part of cell | "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] | 10 | 2.545711e-02 | 3 |
| GO:CC | GO:0070820 | tertiary granule | "A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] | 6 | 3.886369e-02 | 3 |
| GO:CC | GO:0032154 | cleavage furrow | "The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409] | 4 | 4.170962e-02 | 3 |
| GO:CC | GO:0071664 | catenin-TCF7L2 complex | "A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:rl, GOC:vk, PMID:14661054] | 2 | 4.173573e-02 | 3 |
| GO:CC | GO:0036457 | keratohyalin granule | "A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope." [GOC:krc, PMID:15854042] | 2 | 4.173573e-02 | 3 |
| GO:CC | GO:0030175 | filopodium | "Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194] | 5 | 4.829297e-02 | 3 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003779 | actin binding | "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 40 | 1.728558e-36 | 3 |
| GO:MF | GO:0008092 | cytoskeletal protein binding | "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] | 50 | 2.012782e-34 | 3 |
| GO:MF | GO:0051015 | actin filament binding | "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] | 30 | 1.602165e-32 | 3 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 24 | 4.351126e-18 | 3 |
| GO:MF | GO:0044877 | protein-containing complex binding | "Binding to a macromolecular complex." [GOC:jl] | 39 | 2.574978e-17 | 3 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 27 | 4.035297e-16 | 3 |
| GO:MF | GO:0005200 | structural constituent of cytoskeleton | "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] | 13 | 1.604656e-11 | 3 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 102 | 2.297245e-07 | 3 |
| GO:MF | GO:0000146 | microfilament motor activity | "A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949] | 7 | 4.665729e-07 | 3 |
| GO:MF | GO:0019899 | enzyme binding | "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] | 34 | 4.847423e-07 | 3 |
| GO:MF | GO:0005198 | structural molecule activity | "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] | 24 | 1.041085e-06 | 3 |
| GO:MF | GO:0003774 | cytoskeletal motor activity | "Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)." [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949] | 9 | 5.337424e-06 | 3 |
| GO:MF | GO:0019904 | protein domain specific binding | "Binding to a specific domain of a protein." [GOC:go_curators] | 17 | 2.741942e-05 | 3 |
| GO:MF | GO:0005516 | calmodulin binding | "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] | 10 | 8.141948e-05 | 3 |
| GO:MF | GO:0120544 | polypeptide conformation or assembly isomerase activity | "Catalysis of a reaction that alters the conformation or assembly of a polypeptide." [EC:5.6.1.-] | 8 | 1.384618e-04 | 3 |
| GO:MF | GO:0043531 | ADP binding | "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl] | 6 | 1.983376e-04 | 3 |
| GO:MF | GO:0042802 | identical protein binding | "Binding to an identical protein or proteins." [GOC:jl] | 30 | 2.407619e-04 | 3 |
| GO:MF | GO:0019900 | kinase binding | "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] | 17 | 4.323669e-04 | 3 |
| GO:MF | GO:0051020 | GTPase binding | "Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai] | 11 | 4.908583e-04 | 3 |
| GO:MF | GO:0044325 | transmembrane transporter binding | "Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372] | 8 | 4.978290e-04 | 3 |
| GO:MF | GO:0019901 | protein kinase binding | "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] | 16 | 5.382839e-04 | 3 |
| GO:MF | GO:0005509 | calcium ion binding | "Binding to a calcium ion (Ca2+)." [GOC:ai] | 16 | 6.690844e-04 | 3 |
| GO:MF | GO:0008307 | structural constituent of muscle | "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] | 5 | 1.555747e-03 | 3 |
| GO:MF | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | "Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl] | 6 | 3.084069e-03 | 3 |
| GO:MF | GO:0099186 | structural constituent of postsynapse | "The action of a molecule that contributes to the structural integrity of a postsynapse." [GOC:dos] | 4 | 4.187769e-03 | 3 |
| GO:MF | GO:0098918 | structural constituent of synapse | "The action of a molecule that contributes to the structural integrity of a synapse." [GOC:dos] | 4 | 7.941596e-03 | 3 |
| GO:MF | GO:0098973 | structural constituent of postsynaptic actin cytoskeleton | "The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton." [GOC:dos] | 3 | 9.900674e-03 | 3 |
| GO:MF | GO:0120543 | macromolecular conformation isomerase activity | "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] | 9 | 1.266424e-02 | 3 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 13 | 1.340348e-02 | 3 |
| GO:MF | GO:0045294 | alpha-catenin binding | "Binding to catenin complex alpha subunit." [GOC:bf] | 3 | 1.356206e-02 | 3 |
| GO:MF | GO:1902936 | phosphatidylinositol bisphosphate binding | "Binding to phosphatidylinositol bisphosphate." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034] | 6 | 1.383875e-02 | 3 |
| GO:MF | GO:1901981 | phosphatidylinositol phosphate binding | "Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487] | 7 | 2.765675e-02 | 3 |
| GO:MF | GO:0044548 | S100 protein binding | "Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] | 3 | 2.958146e-02 | 3 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 29 | 4.491367e-02 | 3 |
| GO:MF | GO:0005488 | binding | "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] | 105 | 4.647874e-02 | 3 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0030029 | actin filament-based process | "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] | 44 | 9.908325e-32 | 3 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 41 | 4.749056e-30 | 3 |
| GO:BP | GO:0007010 | cytoskeleton organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] | 52 | 3.538696e-29 | 3 |
| GO:BP | GO:0007015 | actin filament organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] | 33 | 1.380878e-26 | 3 |
| GO:BP | GO:0097435 | supramolecular fiber organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] | 39 | 9.299750e-25 | 3 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 61 | 3.659291e-19 | 3 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] | 22 | 1.090099e-14 | 3 |
| GO:BP | GO:0110053 | regulation of actin filament organization | "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv] | 18 | 1.006300e-12 | 3 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 20 | 3.731584e-12 | 3 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] | 19 | 4.306277e-12 | 3 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 43 | 5.903367e-12 | 3 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 22 | 8.531775e-12 | 3 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] | 45 | 9.910604e-12 | 3 |
| GO:BP | GO:0007155 | cell adhesion | "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] | 34 | 2.240500e-11 | 3 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] | 28 | 4.480402e-11 | 3 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 29 | 1.436275e-10 | 3 |
| GO:BP | GO:0030048 | actin filament-based movement | "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] | 13 | 2.114666e-10 | 3 |
| GO:BP | GO:0008064 | regulation of actin polymerization or depolymerization | "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] | 13 | 5.827839e-10 | 3 |
| GO:BP | GO:0030832 | regulation of actin filament length | "Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah] | 13 | 7.574620e-10 | 3 |
| GO:BP | GO:0016043 | cellular component organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] | 75 | 1.147778e-09 | 3 |
| GO:BP | GO:0030835 | negative regulation of actin filament depolymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah] | 9 | 1.268628e-09 | 3 |
| GO:BP | GO:0030833 | regulation of actin filament polymerization | "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] | 12 | 2.510808e-09 | 3 |
| GO:BP | GO:0031032 | actomyosin structure organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] | 14 | 3.758300e-09 | 3 |
| GO:BP | GO:0032272 | negative regulation of protein polymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 10 | 3.776198e-09 | 3 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] | 75 | 5.063348e-09 | 3 |
| GO:BP | GO:0030834 | regulation of actin filament depolymerization | "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] | 9 | 7.653525e-09 | 3 |
| GO:BP | GO:0048856 | anatomical structure development | "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] | 62 | 1.269929e-08 | 3 |
| GO:BP | GO:0008154 | actin polymerization or depolymerization | "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] | 13 | 1.678794e-08 | 3 |
| GO:BP | GO:0030837 | negative regulation of actin filament polymerization | "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] | 9 | 1.803144e-08 | 3 |
| GO:BP | GO:0030042 | actin filament depolymerization | "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] | 9 | 1.803144e-08 | 3 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 42 | 2.258255e-08 | 3 |
| GO:BP | GO:0032271 | regulation of protein polymerization | "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] | 13 | 2.821687e-08 | 3 |
| GO:BP | GO:0051693 | actin filament capping | "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] | 8 | 3.148001e-08 | 3 |
| GO:BP | GO:0030041 | actin filament polymerization | "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] | 12 | 3.867621e-08 | 3 |
| GO:BP | GO:0032502 | developmental process | "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] | 64 | 5.502323e-08 | 3 |
| GO:BP | GO:0048870 | cell motility | "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] | 32 | 6.247166e-08 | 3 |
| GO:BP | GO:0034330 | cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] | 22 | 1.165661e-07 | 3 |
| GO:BP | GO:1901880 | negative regulation of protein depolymerization | "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] | 9 | 1.549340e-07 | 3 |
| GO:BP | GO:0031333 | negative regulation of protein-containing complex assembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] | 11 | 1.853223e-07 | 3 |
| GO:BP | GO:0051494 | negative regulation of cytoskeleton organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 11 | 4.774881e-07 | 3 |
| GO:BP | GO:0043242 | negative regulation of protein-containing complex disassembly | "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] | 9 | 5.042581e-07 | 3 |
| GO:BP | GO:1902904 | negative regulation of supramolecular fiber organization | "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 11 | 5.480775e-07 | 3 |
| GO:BP | GO:0000902 | cell morphogenesis | "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] | 23 | 5.495229e-07 | 3 |
| GO:BP | GO:0051261 | protein depolymerization | "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] | 10 | 7.343286e-07 | 3 |
| GO:BP | GO:0016477 | cell migration | "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] | 28 | 9.389859e-07 | 3 |
| GO:BP | GO:1901879 | regulation of protein depolymerization | "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] | 9 | 1.165017e-06 | 3 |
| GO:BP | GO:0051258 | protein polymerization | "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] | 13 | 2.327034e-06 | 3 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] | 15 | 3.502448e-06 | 3 |
| GO:BP | GO:0009888 | tissue development | "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] | 31 | 6.766678e-06 | 3 |
| GO:BP | GO:0032984 | protein-containing complex disassembly | "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah] | 12 | 8.511180e-06 | 3 |
| GO:BP | GO:0032501 | multicellular organismal process | "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] | 64 | 9.709014e-06 | 3 |
| GO:BP | GO:0051017 | actin filament bundle assembly | "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] | 10 | 1.131438e-05 | 3 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 18 | 1.272624e-05 | 3 |
| GO:BP | GO:0061572 | actin filament bundle organization | "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] | 10 | 1.353635e-05 | 3 |
| GO:BP | GO:0045216 | cell-cell junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 11 | 1.528024e-05 | 3 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 42 | 2.181666e-05 | 3 |
| GO:BP | GO:0043244 | regulation of protein-containing complex disassembly | "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] | 9 | 2.448424e-05 | 3 |
| GO:BP | GO:0006936 | muscle contraction | "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] | 13 | 2.769948e-05 | 3 |
| GO:BP | GO:0032535 | regulation of cellular component size | "A process that modulates the size of a cellular component." [GOC:mah] | 13 | 3.504374e-05 | 3 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] | 8 | 4.353405e-05 | 3 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] | 26 | 4.419933e-05 | 3 |
| GO:BP | GO:0034109 | homotypic cell-cell adhesion | "The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add] | 8 | 7.031529e-05 | 3 |
| GO:BP | GO:0150115 | cell-substrate junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] | 8 | 7.593697e-05 | 3 |
| GO:BP | GO:0030030 | cell projection organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917] | 26 | 7.600262e-05 | 3 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] | 22 | 9.522908e-05 | 3 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 29 | 1.095531e-04 | 3 |
| GO:BP | GO:0150105 | protein localization to cell-cell junction | "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] | 5 | 1.241655e-04 | 3 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 20 | 1.335614e-04 | 3 |
| GO:BP | GO:0022607 | cellular component assembly | "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] | 47 | 1.617620e-04 | 3 |
| GO:BP | GO:0060429 | epithelium development | "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] | 22 | 1.672637e-04 | 3 |
| GO:BP | GO:0030239 | myofibril assembly | "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] | 7 | 1.732246e-04 | 3 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 16 | 2.075802e-04 | 3 |
| GO:BP | GO:0021762 | substantia nigra development | "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420] | 6 | 2.104202e-04 | 3 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 34 | 2.226710e-04 | 3 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 34 | 2.474900e-04 | 3 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb] | 14 | 2.594567e-04 | 3 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 12 | 2.739729e-04 | 3 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 37 | 2.780999e-04 | 3 |
| GO:BP | GO:0034329 | cell junction assembly | "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah] | 14 | 2.791324e-04 | 3 |
| GO:BP | GO:0048513 | animal organ development | "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] | 36 | 2.858306e-04 | 3 |
| GO:BP | GO:0031589 | cell-substrate adhesion | "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf] | 12 | 3.095163e-04 | 3 |
| GO:BP | GO:0098609 | cell-cell adhesion | "The attachment of one cell to another cell via adhesion molecules." [GOC:dos] | 19 | 3.744063e-04 | 3 |
| GO:BP | GO:0003012 | muscle system process | "An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] | 13 | 3.919099e-04 | 3 |
| GO:BP | GO:0030155 | regulation of cell adhesion | "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah] | 17 | 4.846266e-04 | 3 |
| GO:BP | GO:0048729 | tissue morphogenesis | "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] | 15 | 5.135857e-04 | 3 |
| GO:BP | GO:0007399 | nervous system development | "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] | 32 | 6.053274e-04 | 3 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 18 | 6.254945e-04 | 3 |
| GO:BP | GO:0030901 | midbrain development | "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [PMID:4975589, PMID:4992177] | 7 | 7.023280e-04 | 3 |
| GO:BP | GO:0044085 | cellular component biogenesis | "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] | 47 | 8.883364e-04 | 3 |
| GO:BP | GO:0055001 | muscle cell development | "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol] | 9 | 1.044208e-03 | 3 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 23 | 1.069102e-03 | 3 |
| GO:BP | GO:0009611 | response to wounding | "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] | 14 | 1.211045e-03 | 3 |
| GO:BP | GO:0048731 | system development | "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] | 41 | 1.316386e-03 | 3 |
| GO:BP | GO:0007043 | cell-cell junction assembly | "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] | 8 | 1.879083e-03 | 3 |
| GO:BP | GO:1903729 | regulation of plasma membrane organization | "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900] | 4 | 1.898158e-03 | 3 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah] | 7 | 2.346680e-03 | 3 |
| GO:BP | GO:0048857 | neural nucleus development | "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021] | 6 | 2.350446e-03 | 3 |
| GO:BP | GO:0061061 | muscle structure development | "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph] | 15 | 2.363036e-03 | 3 |
| GO:BP | GO:0051014 | actin filament severing | "The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234] | 4 | 2.473057e-03 | 3 |
| GO:BP | GO:0042060 | wound healing | "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] | 12 | 2.476569e-03 | 3 |
| GO:BP | GO:0022411 | cellular component disassembly | "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] | 12 | 3.370512e-03 | 3 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 51 | 3.623962e-03 | 3 |
| GO:BP | GO:0070527 | platelet aggregation | "The adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF, GOC:vk] | 6 | 3.829099e-03 | 3 |
| GO:BP | GO:0007275 | multicellular organism development | "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] | 44 | 4.194436e-03 | 3 |
| GO:BP | GO:0051649 | establishment of localization in cell | "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] | 26 | 4.430461e-03 | 3 |
| GO:BP | GO:0007160 | cell-matrix adhesion | "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] | 9 | 4.656078e-03 | 3 |
| GO:BP | GO:1902905 | positive regulation of supramolecular fiber organization | "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] | 8 | 4.857204e-03 | 3 |
| GO:BP | GO:0048523 | negative regulation of cellular process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 49 | 5.210721e-03 | 3 |
| GO:BP | GO:0030154 | cell differentiation | "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] | 42 | 5.465018e-03 | 3 |
| GO:BP | GO:0048869 | cellular developmental process | "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] | 42 | 5.498463e-03 | 3 |
| GO:BP | GO:0048468 | cell development | "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] | 32 | 5.565267e-03 | 3 |
| GO:BP | GO:0051495 | positive regulation of cytoskeleton organization | "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] | 8 | 7.026612e-03 | 3 |
| GO:BP | GO:0048041 | focal adhesion assembly | "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jid, GOC:mah] | 6 | 7.398061e-03 | 3 |
| GO:BP | GO:1905684 | regulation of plasma membrane repair | "Any process that modulates the frequency, rate or extent of plasma membrane repair." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583] | 3 | 8.071913e-03 | 3 |
| GO:BP | GO:0042692 | muscle cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] | 11 | 8.647460e-03 | 3 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 48 | 9.139853e-03 | 3 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 12 | 9.257468e-03 | 3 |
| GO:BP | GO:0010927 | cellular component assembly involved in morphogenesis | "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] | 7 | 1.007307e-02 | 3 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system." [GOC:dph, GOC:mah, GOC:tb] | 7 | 1.007307e-02 | 3 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] | 12 | 1.159184e-02 | 3 |
| GO:BP | GO:0051016 | barbed-end actin filament capping | "The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] | 4 | 1.276214e-02 | 3 |
| GO:BP | GO:0048519 | negative regulation of biological process | "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 49 | 1.551720e-02 | 3 |
| GO:BP | GO:0046907 | intracellular transport | "The directed movement of substances within a cell." [GOC:ai] | 20 | 1.684109e-02 | 3 |
| GO:BP | GO:0034332 | adherens junction organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah] | 5 | 1.728138e-02 | 3 |
| GO:BP | GO:0022008 | neurogenesis | "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] | 23 | 1.876057e-02 | 3 |
| GO:BP | GO:0048518 | positive regulation of biological process | "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] | 51 | 2.163044e-02 | 3 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | "Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] | 8 | 2.182484e-02 | 3 |
| GO:BP | GO:0032231 | regulation of actin filament bundle assembly | "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] | 6 | 2.256027e-02 | 3 |
| GO:BP | GO:0002064 | epithelial cell development | "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] | 8 | 2.333108e-02 | 3 |
| GO:BP | GO:0032233 | positive regulation of actin filament bundle assembly | "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] | 5 | 2.620524e-02 | 3 |
| GO:BP | GO:0030050 | vesicle transport along actin filament | "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] | 3 | 2.738615e-02 | 3 |
| GO:BP | GO:0090109 | regulation of cell-substrate junction assembly | "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb] | 5 | 2.835642e-02 | 3 |
| GO:BP | GO:0051893 | regulation of focal adhesion assembly | "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai] | 5 | 2.835642e-02 | 3 |
| GO:BP | GO:0030855 | epithelial cell differentiation | "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] | 14 | 2.841148e-02 | 3 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] | 8 | 3.768238e-02 | 3 |
| GO:BP | GO:0055002 | striated muscle cell development | "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol] | 7 | 4.093706e-02 | 3 |
| GO:BP | GO:0150116 | regulation of cell-substrate junction organization | "Any process that modulates the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] | 5 | 4.126320e-02 | 3 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 17 | 4.178048e-02 | 3 |
| GO:BP | GO:0008544 | epidermis development | "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] | 10 | 4.763593e-02 | 3 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 15 | 4.939162e-02 | 3 |
| GO:BP | GO:1903923 | positive regulation of protein processing in phagocytic vesicle | "Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] | 2 | 4.966734e-02 | 3 |
| GO:BP | GO:1900756 | protein processing in phagocytic vesicle | "Protein processing that takes place in the phagosome. Most protein processing in the phagosome represents protein degradation." [GOC:rjd, GOC:TermGenie] | 2 | 4.966734e-02 | 3 |
| GO:BP | GO:1903921 | regulation of protein processing in phagocytic vesicle | "Any process that modulates the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] | 2 | 4.966734e-02 | 3 |
| GO:BP | GO:0099515 | actin filament-based transport | "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb] | 3 | 4.985801e-02 | 3 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-194315 | Signaling by Rho GTPases | Signaling by Rho GTPases | 40 | 6.521779e-24 | 3 |
| REAC | REAC:R-HSA-9716542 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 40 | 1.468222e-23 | 3 |
| REAC | REAC:R-HSA-195258 | RHO GTPase Effectors | RHO GTPase Effectors | 22 | 2.811465e-13 | 3 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 50 | 9.963546e-11 | 3 |
| REAC | REAC:R-HSA-9012999 | RHO GTPase cycle | RHO GTPase cycle | 21 | 3.048696e-09 | 3 |
| REAC | REAC:R-HSA-445355 | Smooth Muscle Contraction | Smooth Muscle Contraction | 9 | 8.231199e-09 | 3 |
| REAC | REAC:R-HSA-5625740 | RHO GTPases activate PKNs | RHO GTPases activate PKNs | 11 | 2.912883e-08 | 3 |
| REAC | REAC:R-HSA-5627123 | RHO GTPases activate PAKs | RHO GTPases activate PAKs | 7 | 4.169709e-08 | 3 |
| REAC | REAC:R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 10 | 4.398343e-08 | 3 |
| REAC | REAC:R-HSA-390522 | Striated Muscle Contraction | Striated Muscle Contraction | 8 | 6.802737e-08 | 3 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 13 | 1.948728e-07 | 3 |
| REAC | REAC:R-HSA-2682334 | EPH-Ephrin signaling | EPH-Ephrin signaling | 10 | 4.213206e-07 | 3 |
| REAC | REAC:R-HSA-397014 | Muscle contraction | Muscle contraction | 13 | 1.130135e-06 | 3 |
| REAC | REAC:R-HSA-5627117 | RHO GTPases Activate ROCKs | RHO GTPases Activate ROCKs | 6 | 1.417228e-06 | 3 |
| REAC | REAC:R-HSA-5625900 | RHO GTPases activate CIT | RHO GTPases activate CIT | 6 | 1.417228e-06 | 3 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 13 | 1.520068e-06 | 3 |
| REAC | REAC:R-HSA-9706574 | RHOBTB GTPase Cycle | RHOBTB GTPase Cycle | 7 | 2.217593e-06 | 3 |
| REAC | REAC:R-HSA-9013424 | RHOV GTPase cycle | RHOV GTPase cycle | 7 | 3.354829e-06 | 3 |
| REAC | REAC:R-HSA-111465 | Apoptotic cleavage of cellular proteins | Apoptotic cleavage of cellular proteins | 7 | 3.354829e-06 | 3 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 27 | 4.409598e-06 | 3 |
| REAC | REAC:R-HSA-1500931 | Cell-Cell communication | Cell-Cell communication | 11 | 5.062546e-06 | 3 |
| REAC | REAC:R-HSA-9013418 | RHOBTB2 GTPase cycle | RHOBTB2 GTPase cycle | 6 | 5.149180e-06 | 3 |
| REAC | REAC:R-HSA-190873 | Gap junction degradation | Gap junction degradation | 5 | 6.127659e-06 | 3 |
| REAC | REAC:R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 5 | 6.127659e-06 | 3 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 17 | 8.391938e-06 | 3 |
| REAC | REAC:R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 5 | 9.899393e-06 | 3 |
| REAC | REAC:R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 5 | 2.283007e-05 | 3 |
| REAC | REAC:R-HSA-111447 | Activation of BAD and translocation to mitochondria | Activation of BAD and translocation to mitochondria | 5 | 2.283007e-05 | 3 |
| REAC | REAC:R-HSA-6798695 | Neutrophil degranulation | Neutrophil degranulation | 17 | 2.326105e-05 | 3 |
| REAC | REAC:R-HSA-9659379 | Sensory processing of sound | Sensory processing of sound | 8 | 2.697290e-05 | 3 |
| REAC | REAC:R-HSA-75153 | Apoptotic execution phase | Apoptotic execution phase | 7 | 3.469522e-05 | 3 |
| REAC | REAC:R-HSA-199991 | Membrane Trafficking | Membrane Trafficking | 19 | 4.391878e-05 | 3 |
| REAC | REAC:R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | Sensory processing of sound by outer hair cells of the cochlea | 7 | 4.564400e-05 | 3 |
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 36 | 7.119806e-05 | 3 |
| REAC | REAC:R-HSA-9013420 | RHOU GTPase cycle | RHOU GTPase cycle | 6 | 1.513486e-04 | 3 |
| REAC | REAC:R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | Sensory processing of sound by inner hair cells of the cochlea | 7 | 2.133627e-04 | 3 |
| REAC | REAC:R-HSA-196025 | Formation of annular gap junctions | Formation of annular gap junctions | 4 | 3.604772e-04 | 3 |
| REAC | REAC:R-HSA-5653656 | Vesicle-mediated transport | Vesicle-mediated transport | 19 | 3.810467e-04 | 3 |
| REAC | REAC:R-HSA-1266738 | Developmental Biology | Developmental Biology | 27 | 5.071958e-04 | 3 |
| REAC | REAC:R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | Caspase-mediated cleavage of cytoskeletal proteins | 4 | 5.376519e-04 | 3 |
| REAC | REAC:R-HSA-446728 | Cell junction organization | Cell junction organization | 8 | 7.747316e-04 | 3 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 16 | 7.930377e-04 | 3 |
| REAC | REAC:R-HSA-6802957 | Oncogenic MAPK signaling | Oncogenic MAPK signaling | 7 | 9.465513e-04 | 3 |
| REAC | REAC:R-HSA-114452 | Activation of BH3-only proteins | Activation of BH3-only proteins | 5 | 9.924972e-04 | 3 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 16 | 1.421380e-03 | 3 |
| REAC | REAC:R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | Signaling by high-kinase activity BRAF mutants | 5 | 2.195909e-03 | 3 |
| REAC | REAC:R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | Signaling by BRAF and RAF1 fusions | 6 | 2.998922e-03 | 3 |
| REAC | REAC:R-HSA-373755 | Semaphorin interactions | Semaphorin interactions | 6 | 2.998922e-03 | 3 |
| REAC | REAC:R-HSA-446353 | Cell-extracellular matrix interactions | Cell-extracellular matrix interactions | 4 | 3.212322e-03 | 3 |
| REAC | REAC:R-HSA-5674135 | MAP2K and MAPK activation | MAP2K and MAPK activation | 5 | 3.804768e-03 | 3 |
| REAC | REAC:R-HSA-9656223 | Signaling by RAF1 mutants | Signaling by RAF1 mutants | 5 | 4.323020e-03 | 3 |
| REAC | REAC:R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | Sema4D induced cell migration and growth-cone collapse | 4 | 5.028773e-03 | 3 |
| REAC | REAC:R-HSA-9649948 | Signaling downstream of RAS mutants | Signaling downstream of RAS mutants | 5 | 7.796165e-03 | 3 |
| REAC | REAC:R-HSA-6802949 | Signaling by RAS mutants | Signaling by RAS mutants | 5 | 7.796165e-03 | 3 |
| REAC | REAC:R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | Signaling by moderate kinase activity BRAF mutants | 5 | 7.796165e-03 | 3 |
| REAC | REAC:R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5 | 7.796165e-03 | 3 |
| REAC | REAC:R-HSA-9664407 | Parasite infection | Parasite infection | 7 | 7.989913e-03 | 3 |
| REAC | REAC:R-HSA-9664417 | Leishmania phagocytosis | Leishmania phagocytosis | 7 | 7.989913e-03 | 3 |
| REAC | REAC:R-HSA-9664422 | FCGR3A-mediated phagocytosis | FCGR3A-mediated phagocytosis | 7 | 7.989913e-03 | 3 |
| REAC | REAC:R-HSA-373753 | Nephrin family interactions | Nephrin family interactions | 4 | 9.035781e-03 | 3 |
| REAC | REAC:R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | Regulation of actin dynamics for phagocytic cup formation | 7 | 9.475202e-03 | 3 |
| REAC | REAC:R-HSA-400685 | Sema4D in semaphorin signaling | Sema4D in semaphorin signaling | 4 | 1.078162e-02 | 3 |
| REAC | REAC:R-HSA-190828 | Gap junction trafficking | Gap junction trafficking | 5 | 1.188764e-02 | 3 |
| REAC | REAC:R-HSA-157858 | Gap junction trafficking and regulation | Gap junction trafficking and regulation | 5 | 1.313176e-02 | 3 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 29 | 1.337937e-02 | 3 |
| REAC | REAC:R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Regulation of PLK1 Activity at G2/M Transition | 6 | 1.544870e-02 | 3 |
| REAC | REAC:R-HSA-109606 | Intrinsic Pathway for Apoptosis | Intrinsic Pathway for Apoptosis | 5 | 1.914936e-02 | 3 |
| REAC | REAC:R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | Signaling by ALK fusions and activated point mutants | 6 | 2.004650e-02 | 3 |
| REAC | REAC:R-HSA-9700206 | Signaling by ALK in cancer | Signaling by ALK in cancer | 6 | 2.004650e-02 | 3 |
| REAC | REAC:R-HSA-3928663 | EPHA-mediated growth cone collapse | EPHA-mediated growth cone collapse | 4 | 2.030911e-02 | 3 |
| REAC | REAC:R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | Entry of Influenza Virion into Host Cell via Endocytosis | 2 | 2.176891e-02 | 3 |
| REAC | REAC:R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | Apoptotic cleavage of cell adhesion proteins | 3 | 2.501468e-02 | 3 |
| REAC | REAC:R-HSA-445095 | Interaction between L1 and Ankyrins | Interaction between L1 and Ankyrins | 4 | 3.068413e-02 | 3 |
| REAC | REAC:R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | Fcgamma receptor (FCGR) dependent phagocytosis | 7 | 3.162421e-02 | 3 |
| REAC | REAC:R-HSA-9614399 | Regulation of localization of FOXO transcription factors | Regulation of localization of FOXO transcription factors | 3 | 3.317369e-02 | 3 |
| REAC | REAC:R-HSA-5626467 | RHO GTPases activate IQGAPs | RHO GTPases activate IQGAPs | 4 | 3.486954e-02 | 3 |
| REAC | REAC:R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs | RHO GTPases Activate WASPs and WAVEs | 4 | 4.991721e-02 | 3 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04814 | Motor proteins | Motor proteins | 18 | 5.847508e-13 | 3 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 16 | 1.724166e-09 | 3 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 14 | 6.975984e-07 | 3 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | Bacterial invasion of epithelial cells | 9 | 7.373453e-07 | 3 |
| KEGG | KEGG:04390 | Hippo signaling pathway | Hippo signaling pathway | 11 | 3.458815e-06 | 3 |
| KEGG | KEGG:04520 | Adherens junction | Adherens junction | 9 | 3.967597e-06 | 3 |
| KEGG | KEGG:04530 | Tight junction | Tight junction | 11 | 7.857000e-06 | 3 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 11 | 3.506633e-05 | 3 |
| KEGG | KEGG:04510 | Focal adhesion | Focal adhesion | 10 | 3.650960e-04 | 3 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | Proteoglycans in cancer | 10 | 4.164301e-04 | 3 |
| KEGG | KEGG:05131 | Shigellosis | Shigellosis | 10 | 2.058124e-03 | 3 |
| KEGG | KEGG:04114 | Oocyte meiosis | Oocyte meiosis | 7 | 6.756484e-03 | 3 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | Hypertrophic cardiomyopathy | 6 | 9.986031e-03 | 3 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | Dilated cardiomyopathy | 6 | 1.318134e-02 | 3 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 7 | 2.087370e-02 | 3 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 7 | 2.170178e-02 | 3 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | Leukocyte transendothelial migration | 6 | 2.418740e-02 | 3 |
| KEGG | KEGG:04611 | Platelet activation | Platelet activation | 6 | 3.800406e-02 | 3 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | Arrhythmogenic right ventricular cardiomyopathy | 5 | 4.494226e-02 | 3 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 28 | 6.416998e-08 | 3 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 21 | 8.665749e-06 | 3 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 15 | 1.016222e-05 | 3 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 20 | 1.344426e-05 | 3 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 23 | 2.085678e-05 | 3 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 24 | 2.323399e-05 | 3 |
| HPA | HPA:0470183 | Skin 2; cells in granular layer[High] | Skin 2; cells in granular layer[High] | 13 | 2.827838e-05 | 3 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 23 | 5.286413e-05 | 3 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 25 | 1.136375e-04 | 3 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 18 | 1.344781e-04 | 3 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 18 | 1.532405e-04 | 3 |
| HPA | HPA:0471402 | Skin 2; cells in corneal layer[≥Medium] | Skin 2; cells in corneal layer[≥Medium] | 8 | 1.767641e-04 | 3 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 12 | 2.131205e-04 | 3 |
| HPA | HPA:0471401 | Skin 2; cells in corneal layer[≥Low] | Skin 2; cells in corneal layer[≥Low] | 9 | 4.804737e-04 | 3 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 21 | 7.494422e-04 | 3 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 19 | 1.050337e-03 | 3 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 18 | 1.250798e-03 | 3 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 19 | 1.261799e-03 | 3 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 18 | 1.546386e-03 | 3 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 20 | 1.597658e-03 | 3 |
| HPA | HPA:0461403 | Skin 1; cells in corneal layer[High] | Skin 1; cells in corneal layer[High] | 5 | 1.692372e-03 | 3 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 21 | 1.807813e-03 | 3 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 22 | 2.028863e-03 | 3 |
| HPA | HPA:0471403 | Skin 2; cells in corneal layer[High] | Skin 2; cells in corneal layer[High] | 5 | 2.636140e-03 | 3 |
| HPA | HPA:0031323 | Appendix; enterocytes - Microvilli[High] | Appendix; enterocytes - Microvilli[High] | 7 | 2.758673e-03 | 3 |
| HPA | HPA:0461401 | Skin 1; cells in corneal layer[≥Low] | Skin 1; cells in corneal layer[≥Low] | 7 | 2.758673e-03 | 3 |
| HPA | HPA:0461402 | Skin 1; cells in corneal layer[≥Medium] | Skin 1; cells in corneal layer[≥Medium] | 6 | 3.417649e-03 | 3 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 19 | 4.672072e-03 | 3 |
| HPA | HPA:0471443 | Skin 2; fibrohistiocytic cells[High] | Skin 2; fibrohistiocytic cells[High] | 14 | 6.525992e-03 | 3 |
| HPA | HPA:0401321 | Rectum; enterocytes - Microvilli[≥Low] | Rectum; enterocytes - Microvilli[≥Low] | 9 | 8.963819e-03 | 3 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 17 | 9.122938e-03 | 3 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 18 | 1.004571e-02 | 3 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 77 | 1.066813e-02 | 3 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 16 | 1.725416e-02 | 3 |
| HPA | HPA:0270351 | Kidney; cells in glomeruli[≥Low] | Kidney; cells in glomeruli[≥Low] | 61 | 2.021594e-02 | 3 |
| HPA | HPA:0031322 | Appendix; enterocytes - Microvilli[≥Medium] | Appendix; enterocytes - Microvilli[≥Medium] | 8 | 2.115093e-02 | 3 |
| HPA | HPA:0050092 | Breast; myoepithelial cells[≥Medium] | Breast; myoepithelial cells[≥Medium] | 49 | 2.342246e-02 | 3 |
| HPA | HPA:0030432 | Appendix; germinal center cells[≥Medium] | Appendix; germinal center cells[≥Medium] | 9 | 2.497440e-02 | 3 |
| HPA | HPA:0030433 | Appendix; germinal center cells[High] | Appendix; germinal center cells[High] | 6 | 2.541146e-02 | 3 |
| HPA | HPA:0401322 | Rectum; enterocytes - Microvilli[≥Medium] | Rectum; enterocytes - Microvilli[≥Medium] | 8 | 2.687801e-02 | 3 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 64 | 4.336923e-02 | 3 |
| HPA | HPA:0461421 | Skin 1; eccrine glands[≥Low] | Skin 1; eccrine glands[≥Low] | 9 | 4.743606e-02 | 3 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP383 | Striated muscle contraction pathway | Striated muscle contraction pathway | 8 | 1.571283e-07 | 3 |
| WP | WP:WP3888 | VEGFA VEGFR2 signaling | VEGFA VEGFR2 signaling | 18 | 3.123775e-06 | 3 |
| WP | WP:WP2272 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 8 | 3.476702e-06 | 3 |
| WP | WP:WP2572 | Primary focal segmental glomerulosclerosis FSGS | Primary focal segmental glomerulosclerosis FSGS | 8 | 3.037280e-05 | 3 |
| WP | WP:WP51 | Regulation of actin cytoskeleton | Regulation of actin cytoskeleton | 10 | 9.852899e-05 | 3 |
| WP | WP:WP5376 | 17p13 3 YWHAE copy number variation | 17p13 3 YWHAE copy number variation | 5 | 1.409124e-04 | 3 |
| WP | WP:WP4534 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms | 6 | 4.457068e-04 | 3 |
| WP | WP:WP306 | Focal adhesion | Focal adhesion | 10 | 1.301754e-03 | 3 |
| WP | WP:WP4217 | Ebola virus infection in host | Ebola virus infection in host | 8 | 2.459340e-03 | 3 |
| WP | WP:WP2118 | Arrhythmogenic right ventricular cardiomyopathy | Arrhythmogenic right ventricular cardiomyopathy | 6 | 7.273352e-03 | 3 |
| WP | WP:WP289 | Myometrial relaxation and contraction pathways | Myometrial relaxation and contraction pathways | 8 | 9.365754e-03 | 3 |
| WP | WP:WP2814 | Mammary gland development puberty stage 2 of 4 | Mammary gland development puberty stage 2 of 4 | 3 | 3.019182e-02 | 3 |
| WP | WP:WP2005 | miR targeted genes in muscle cell | miR targeted genes in muscle cell | 11 | 3.543221e-02 | 3 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-34a-5p | hsa-mir-34a-5p | hsa-mir-34a-5p | 16 | 0.000277 | 3 |
| MIRNA | MIRNA:hsa-mir-1-3p | hsa-mir-1-3p | hsa-mir-1-3p | 20 | 0.000297 | 3 |
| MIRNA | MIRNA:hsa-mir-16-5p | hsa-mir-16-5p | hsa-mir-16-5p | 26 | 0.000619 | 3 |
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 20 | 0.000781 | 3 |
| MIRNA | MIRNA:hsa-let-7e-5p | hsa-let-7e-5p | hsa-let-7e-5p | 14 | 0.007835 | 3 |
| MIRNA | MIRNA:hsa-mir-33b-5p | hsa-mir-33b-5p | hsa-mir-33b-5p | 6 | 0.014408 | 3 |
| MIRNA | MIRNA:hsa-mir-145-5p | hsa-mir-145-5p | hsa-mir-145-5p | 9 | 0.014669 | 3 |
| MIRNA | MIRNA:hsa-mir-222-3p | hsa-mir-222-3p | hsa-mir-222-3p | 11 | 0.018323 | 3 |
| MIRNA | MIRNA:hsa-mir-544a | hsa-mir-544a | hsa-mir-544a | 7 | 0.020045 | 3 |
| MIRNA | MIRNA:hsa-mir-4474-3p | hsa-mir-4474-3p | hsa-mir-4474-3p | 16 | 0.024144 | 3 |
| MIRNA | MIRNA:hsa-mir-218-5p | hsa-mir-218-5p | hsa-mir-218-5p | 16 | 0.024519 | 3 |
| MIRNA | MIRNA:hsa-mir-4521 | hsa-mir-4521 | hsa-mir-4521 | 14 | 0.036500 | 3 |
| MIRNA | MIRNA:hsa-mir-621 | hsa-mir-621 | hsa-mir-621 | 10 | 0.037083 | 3 |
| MIRNA | MIRNA:hsa-mir-33a-5p | hsa-mir-33a-5p | hsa-mir-33a-5p | 7 | 0.049916 | 3 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5199 | Kinase maturation complex 1 | Kinase maturation complex 1 | 5 | 0.000349 | 3 |
| CORUM | CORUM:5604 | Emerin complex 1 | Emerin complex 1 | 4 | 0.000506 | 3 |
| CORUM | CORUM:2837 | Profilin 1 complex | Profilin 1 complex | 3 | 0.006075 | 3 |
| CORUM | CORUM:5177 | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) | 3 | 0.020879 | 3 |
| CORUM | CORUM:5615 | Emerin complex 52 | Emerin complex 52 | 4 | 0.025226 | 3 |
| CORUM | CORUM:7312 | CTNNB1-ESR1 complex | CTNNB1-ESR1 complex | 2 | 0.049809 | 3 |
| CORUM | CORUM:2254 | CTGF/Hcs24-actin(beta/gamma) complex | CTGF/Hcs24-actin(beta/gamma) complex | 2 | 0.049809 | 3 |
| CORUM | CORUM:817 | MRIP-MBS complex | MRIP-MBS complex | 2 | 0.049809 | 3 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05444_1 | Factor: CPBP; motif: NGGGCGG; match class: 1 | Factor: CPBP; motif: NGGGCGG; match class: 1 | 40 | 0.000595 | 3 |
| TF | TF:M05332_1 | Factor: Sp2; motif: WGGGCGG; match class: 1 | Factor: Sp2; motif: WGGGCGG; match class: 1 | 40 | 0.000595 | 3 |
| TF | TF:M05361_1 | Factor: Sp6; motif: WGGGCGG; match class: 1 | Factor: Sp6; motif: WGGGCGG; match class: 1 | 40 | 0.000595 | 3 |
| TF | TF:M12227_1 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 | Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 | 57 | 0.000731 | 3 |
| TF | TF:M03567_1 | Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 | Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 | 42 | 0.000802 | 3 |
| TF | TF:M03807_1 | Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 | Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 | 46 | 0.000818 | 3 |
| TF | TF:M13127_1 | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS; match class: 1 | Factor: HA95; motif: CCSNSSCCNSCNCCWSCCNS; match class: 1 | 70 | 0.002239 | 3 |
| TF | TF:M05327 | Factor: WT1; motif: NGCGGGGGGGTSMMCYN | Factor: WT1; motif: NGCGGGGGGGTSMMCYN | 53 | 0.004248 | 3 |
| TF | TF:M08878 | Factor: EGR; motif: CGCCCCCGCNN | Factor: EGR; motif: CGCCCCCGCNN | 64 | 0.006820 | 3 |
| TF | TF:M12590_1 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1 | Factor: CP2; motif: NRRRCCGGCYNRARCCGGNN; match class: 1 | 59 | 0.011463 | 3 |
| TF | TF:M01303 | Factor: SP1; motif: GGGGYGGGGNS | Factor: SP1; motif: GGGGYGGGGNS | 65 | 0.024957 | 3 |
| TF | TF:M00189_1 | Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 | Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 | 54 | 0.032602 | 3 |
| TF | TF:M07277_1 | Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 | Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 | 42 | 0.036449 | 3 |
| TF | TF:M00196_1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 | 53 | 0.040450 | 3 |
| TF | TF:M09970_1 | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 | Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 | 39 | 0.047085 | 3 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0011876 | Abnormal platelet volume | Anomalous size of platelets. Most normal sized platelets are 1.5 to 3 micrometers in diameter. Large platelets are 4 to 7 micrometers. Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers. | 6 | 0.000768 | 3 |
| HP | HP:0032449 | Abnormal dermoepidermal hemidesmosome morphology | An abnormal structure or appearance of hemidesmosomes, multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane. | 4 | 0.002982 | 3 |
| HP | HP:0031538 | Abnormal dermoepidermal junction morphology | Any anomaly of the structure of the acellular zone that is between the dermis and the epidermis and which functions to bind the epidermis to the dermis and to serve as a selective barrier allowing the control of molecular and cellular exchanges between the two compartments. | 4 | 0.004442 | 3 |
| HP | HP:0011025 | Abnormal cardiovascular system physiology | Abnormal functionality of the cardiovascular system. | 29 | 0.005627 | 3 |
| HP | HP:0011877 | Increased mean platelet volume | Average platelet volume above the upper limit of the normal reference interval. | 5 | 0.006867 | 3 |
| HP | HP:0008366 | Foot joint contracture | Contractures of one or more joints of the feet meaning chronic loss of joint motion due to structural changes in non-bony tissue. | 9 | 0.010763 | 3 |
| HP | HP:0001648 | Cor pulmonale | Right-sided heart failure resulting from chronic hypertension in the pulmonary arteries and right ventricle. | 4 | 0.011996 | 3 |
| HP | HP:0002067 | Bradykinesia | Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement). | 8 | 0.012130 | 3 |
| HP | HP:0030956 | Abnormality of cardiovascular system electrophysiology | An anomaly of the electrical conduction physiology of the heart. | 17 | 0.012482 | 3 |
| HP | HP:0100308 | Cerebral cortical hemiatrophy | Atrophy of one side of the brain, characterized by findings including thinning of the cerebral cortex, reduced volume of the cerebral white matter with abnormal myelination, and enlargement of the ispilateral fourth ventricle. | 3 | 0.020983 | 3 |
Community 4
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0051086 | chaperone mediated protein folding independent of cofactor | "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] | 8 | 2.573761e-18 | 4 |
| GO:BP | GO:1904874 | positive regulation of telomerase RNA localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 2.311781e-17 | 4 |
| GO:BP | GO:1904869 | regulation of protein localization to Cajal body | "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.153593e-16 | 4 |
| GO:BP | GO:1904871 | positive regulation of protein localization to Cajal body | "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.153593e-16 | 4 |
| GO:BP | GO:1904867 | protein localization to Cajal body | "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.263912e-15 | 4 |
| GO:BP | GO:1903405 | protein localization to nuclear body | "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849] | 8 | 1.263912e-15 | 4 |
| GO:BP | GO:1904872 | regulation of telomerase RNA localization to Cajal body | "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 8 | 1.263912e-15 | 4 |
| GO:BP | GO:0032212 | positive regulation of telomere maintenance via telomerase | "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 9 | 7.305849e-15 | 4 |
| GO:BP | GO:1990173 | protein localization to nucleoplasm | "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952] | 8 | 7.637280e-15 | 4 |
| GO:BP | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 9 | 2.603373e-14 | 4 |
| GO:BP | GO:0090671 | telomerase RNA localization to Cajal body | "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 8 | 1.903183e-13 | 4 |
| GO:BP | GO:0090670 | RNA localization to Cajal body | "A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 8 | 1.903183e-13 | 4 |
| GO:BP | GO:0090672 | telomerase RNA localization | "Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 8 | 1.903183e-13 | 4 |
| GO:BP | GO:0090685 | RNA localization to nucleus | "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] | 8 | 1.903183e-13 | 4 |
| GO:BP | GO:0019538 | protein metabolic process | "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] | 41 | 6.194942e-13 | 4 |
| GO:BP | GO:0007004 | telomere maintenance via telomerase | "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] | 10 | 8.615096e-13 | 4 |
| GO:BP | GO:0006278 | RNA-templated DNA biosynthetic process | "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] | 10 | 1.451880e-12 | 4 |
| GO:BP | GO:0032210 | regulation of telomere maintenance via telomerase | "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] | 9 | 5.894501e-12 | 4 |
| GO:BP | GO:0010833 | telomere maintenance via telomere lengthening | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] | 10 | 6.921886e-12 | 4 |
| GO:BP | GO:0032206 | positive regulation of telomere maintenance | "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 10 | 9.198749e-12 | 4 |
| GO:BP | GO:2000573 | positive regulation of DNA biosynthetic process | "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 9 | 1.611742e-11 | 4 |
| GO:BP | GO:1904356 | regulation of telomere maintenance via telomere lengthening | "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] | 9 | 3.342034e-11 | 4 |
| GO:BP | GO:2001252 | positive regulation of chromosome organization | "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] | 10 | 3.019199e-10 | 4 |
| GO:BP | GO:0051084 | 'de novo' post-translational protein folding | "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] | 8 | 3.481037e-10 | 4 |
| GO:BP | GO:0061077 | chaperone-mediated protein folding | "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] | 9 | 5.595373e-10 | 4 |
| GO:BP | GO:0032204 | regulation of telomere maintenance | "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] | 10 | 5.842522e-10 | 4 |
| GO:BP | GO:0000723 | telomere maintenance | "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] | 11 | 8.246038e-10 | 4 |
| GO:BP | GO:0006458 | 'de novo' protein folding | "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] | 8 | 8.968813e-10 | 4 |
| GO:BP | GO:0050821 | protein stabilization | "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] | 12 | 9.324006e-10 | 4 |
| GO:BP | GO:2000278 | regulation of DNA biosynthetic process | "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] | 9 | 4.244525e-09 | 4 |
| GO:BP | GO:0032200 | telomere organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] | 11 | 4.396772e-09 | 4 |
| GO:BP | GO:0031647 | regulation of protein stability | "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] | 13 | 5.376096e-09 | 4 |
| GO:BP | GO:1900182 | positive regulation of protein localization to nucleus | "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 9 | 5.706802e-09 | 4 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] | 16 | 6.702493e-09 | 4 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] | 16 | 8.502707e-09 | 4 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] | 16 | 9.562190e-09 | 4 |
| GO:BP | GO:0006457 | protein folding | "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] | 11 | 1.948562e-08 | 4 |
| GO:BP | GO:0007339 | binding of sperm to zona pellucida | "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] | 7 | 1.966967e-08 | 4 |
| GO:BP | GO:0071897 | DNA biosynthetic process | "The biosynthetic process resulting in the formation of DNA." [GOC:mah] | 10 | 4.391603e-08 | 4 |
| GO:BP | GO:1903829 | positive regulation of protein localization | "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 14 | 5.361661e-08 | 4 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] | 13 | 7.604887e-08 | 4 |
| GO:BP | GO:0030163 | protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] | 18 | 1.175131e-07 | 4 |
| GO:BP | GO:0035036 | sperm-egg recognition | "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf] | 7 | 1.584510e-07 | 4 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] | 14 | 1.637356e-07 | 4 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] | 16 | 1.902519e-07 | 4 |
| GO:BP | GO:1900180 | regulation of protein localization to nucleus | "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] | 9 | 2.836347e-07 | 4 |
| GO:BP | GO:0009057 | macromolecule catabolic process | "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] | 20 | 3.384704e-07 | 4 |
| GO:BP | GO:0034504 | protein localization to nucleus | "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] | 11 | 1.054850e-06 | 4 |
| GO:BP | GO:0033044 | regulation of chromosome organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] | 10 | 1.258590e-06 | 4 |
| GO:BP | GO:0032880 | regulation of protein localization | "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] | 16 | 1.542927e-06 | 4 |
| GO:BP | GO:0051604 | protein maturation | "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] | 13 | 1.939059e-06 | 4 |
| GO:BP | GO:0009988 | cell-cell recognition | "Cell recognition between cells. May involve the formation of specialized cell junctions." [ISBN:0824072820] | 7 | 1.952417e-06 | 4 |
| GO:BP | GO:0051276 | chromosome organization | "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] | 13 | 4.148703e-06 | 4 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 10 | 7.461833e-06 | 4 |
| GO:BP | GO:0060341 | regulation of cellular localization | "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] | 16 | 7.567671e-06 | 4 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] | 12 | 8.301658e-06 | 4 |
| GO:BP | GO:0033365 | protein localization to organelle | "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] | 16 | 9.144589e-05 | 4 |
| GO:BP | GO:0006403 | RNA localization | "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] | 8 | 9.672275e-05 | 4 |
| GO:BP | GO:0009056 | catabolic process | "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] | 23 | 1.109274e-04 | 4 |
| GO:BP | GO:0006508 | proteolysis | "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] | 17 | 2.583354e-04 | 4 |
| GO:BP | GO:0008104 | protein localization | "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] | 23 | 2.736383e-04 | 4 |
| GO:BP | GO:0070727 | cellular macromolecule localization | "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] | 23 | 2.964216e-04 | 4 |
| GO:BP | GO:0090666 | scaRNA localization to Cajal body | "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] | 3 | 3.374750e-04 | 4 |
| GO:BP | GO:0008037 | cell recognition | "The process in which a cell in an organism interprets its surroundings." [GOC:go_curators] | 7 | 3.706768e-04 | 4 |
| GO:BP | GO:0051641 | cellular localization | "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] | 26 | 6.243504e-04 | 4 |
| GO:BP | GO:0051128 | regulation of cellular component organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 21 | 6.560833e-04 | 4 |
| GO:BP | GO:0007338 | single fertilization | "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] | 7 | 6.840511e-04 | 4 |
| GO:BP | GO:0032879 | regulation of localization | "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] | 19 | 8.675801e-04 | 4 |
| GO:BP | GO:0033036 | macromolecule localization | "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] | 24 | 1.025578e-03 | 4 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 10 | 1.184477e-03 | 4 |
| GO:BP | GO:0033043 | regulation of organelle organization | "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] | 14 | 2.048816e-03 | 4 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 31 | 2.482984e-03 | 4 |
| GO:BP | GO:0009566 | fertilization | "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] | 7 | 3.017663e-03 | 4 |
| GO:BP | GO:0065008 | regulation of biological quality | "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] | 22 | 3.740763e-03 | 4 |
| GO:BP | GO:0009894 | regulation of catabolic process | "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] | 13 | 4.111246e-03 | 4 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 18 | 4.497451e-03 | 4 |
| GO:BP | GO:0006996 | organelle organization | "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] | 24 | 7.428895e-03 | 4 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] | 13 | 8.013708e-03 | 4 |
| GO:BP | GO:0036211 | protein modification process | "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] | 21 | 8.739799e-03 | 4 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] | 8 | 9.890055e-03 | 4 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] | 20 | 1.520695e-02 | 4 |
| GO:BP | GO:0051179 | localization | "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] | 30 | 1.773030e-02 | 4 |
| GO:BP | GO:0048522 | positive regulation of cellular process | "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] | 31 | 2.095116e-02 | 4 |
| GO:BP | GO:0043412 | macromolecule modification | "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] | 21 | 2.368490e-02 | 4 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] | 16 | 2.696975e-02 | 4 |
| GO:BP | GO:1904851 | positive regulation of establishment of protein localization to telomere | "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] | 2 | 4.024246e-02 | 4 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 24 | 4.715811e-02 | 4 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | Formation of tubulin folding intermediates by CCT/TriC | 11 | 7.382909e-18 | 4 |
| REAC | REAC:R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | Prefoldin mediated transfer of substrate to CCT/TriC | 11 | 2.039701e-17 | 4 |
| REAC | REAC:R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | The role of GTSE1 in G2/M progression after G2 checkpoint | 14 | 3.341692e-17 | 4 |
| REAC | REAC:R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 11 | 1.810828e-16 | 4 |
| REAC | REAC:R-HSA-390450 | Folding of actin by CCT/TriC | Folding of actin by CCT/TriC | 8 | 1.083585e-15 | 4 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 16 | 2.104658e-14 | 4 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 16 | 2.478685e-14 | 4 |
| REAC | REAC:R-HSA-5610787 | Hedgehog 'off' state | Hedgehog 'off' state | 13 | 2.998636e-13 | 4 |
| REAC | REAC:R-HSA-390466 | Chaperonin-mediated protein folding | Chaperonin-mediated protein folding | 12 | 8.180731e-13 | 4 |
| REAC | REAC:R-HSA-391251 | Protein folding | Protein folding | 12 | 1.815851e-12 | 4 |
| REAC | REAC:R-HSA-1234174 | Cellular response to hypoxia | Cellular response to hypoxia | 11 | 4.038015e-12 | 4 |
| REAC | REAC:R-HSA-5358351 | Signaling by Hedgehog | Signaling by Hedgehog | 13 | 1.176192e-11 | 4 |
| REAC | REAC:R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 9 | 1.279904e-11 | 4 |
| REAC | REAC:R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 10 | 5.277310e-11 | 4 |
| REAC | REAC:R-HSA-5689603 | UCH proteinases | UCH proteinases | 11 | 1.353622e-10 | 4 |
| REAC | REAC:R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | Cross-presentation of soluble exogenous antigens (endosomes) | 9 | 1.558644e-10 | 4 |
| REAC | REAC:R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | Regulation of activated PAK-2p34 by proteasome mediated degradation | 9 | 1.894861e-10 | 4 |
| REAC | REAC:R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | Regulation of ornithine decarboxylase (ODC) | 9 | 2.293730e-10 | 4 |
| REAC | REAC:R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | Ubiquitin-dependent degradation of Cyclin D | 9 | 2.765167e-10 | 4 |
| REAC | REAC:R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 9 | 2.765167e-10 | 4 |
| REAC | REAC:R-HSA-180534 | Vpu mediated degradation of CD4 | Vpu mediated degradation of CD4 | 9 | 2.765167e-10 | 4 |
| REAC | REAC:R-HSA-69610 | p53-Independent DNA Damage Response | p53-Independent DNA Damage Response | 9 | 2.765167e-10 | 4 |
| REAC | REAC:R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint | p53-Independent G1/S DNA damage checkpoint | 9 | 2.765167e-10 | 4 |
| REAC | REAC:R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | Autodegradation of the E3 ubiquitin ligase COP1 | 9 | 2.765167e-10 | 4 |
| REAC | REAC:R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 9 | 2.765167e-10 | 4 |
| REAC | REAC:R-HSA-9604323 | Negative regulation of NOTCH4 signaling | Negative regulation of NOTCH4 signaling | 9 | 3.320387e-10 | 4 |
| REAC | REAC:R-HSA-169911 | Regulation of Apoptosis | Regulation of Apoptosis | 9 | 3.320387e-10 | 4 |
| REAC | REAC:R-HSA-180585 | Vif-mediated degradation of APOBEC3G | Vif-mediated degradation of APOBEC3G | 9 | 3.320387e-10 | 4 |
| REAC | REAC:R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | AUF1 (hnRNP D0) binds and destabilizes mRNA | 9 | 3.972043e-10 | 4 |
| REAC | REAC:R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | SCF-beta-TrCP mediated degradation of Emi1 | 9 | 4.734375e-10 | 4 |
| REAC | REAC:R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 9 | 4.734375e-10 | 4 |
| REAC | REAC:R-HSA-8941858 | Regulation of RUNX3 expression and activity | Regulation of RUNX3 expression and activity | 9 | 4.734375e-10 | 4 |
| REAC | REAC:R-HSA-9824272 | Somitogenesis | Somitogenesis | 9 | 4.734375e-10 | 4 |
| REAC | REAC:R-HSA-4641257 | Degradation of AXIN | Degradation of AXIN | 9 | 4.734375e-10 | 4 |
| REAC | REAC:R-HSA-5362768 | Hh mutants are degraded by ERAD | Hh mutants are degraded by ERAD | 9 | 5.623370e-10 | 4 |
| REAC | REAC:R-HSA-4641258 | Degradation of DVL | Degradation of DVL | 9 | 6.656932e-10 | 4 |
| REAC | REAC:R-HSA-69541 | Stabilization of p53 | Stabilization of p53 | 9 | 6.656932e-10 | 4 |
| REAC | REAC:R-HSA-351202 | Metabolism of polyamines | Metabolism of polyamines | 9 | 7.855064e-10 | 4 |
| REAC | REAC:R-HSA-5387390 | Hh mutants abrogate ligand secretion | Hh mutants abrogate ligand secretion | 9 | 9.240073e-10 | 4 |
| REAC | REAC:R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | NIK-->noncanonical NF-kB signaling | 9 | 9.240073e-10 | 4 |
| REAC | REAC:R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | Association of TriC/CCT with target proteins during biosynthesis | 8 | 1.077873e-09 | 4 |
| REAC | REAC:R-HSA-5610783 | Degradation of GLI2 by the proteasome | Degradation of GLI2 by the proteasome | 9 | 1.083677e-09 | 4 |
| REAC | REAC:R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | GLI3 is processed to GLI3R by the proteasome | 9 | 1.083677e-09 | 4 |
| REAC | REAC:R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | Dectin-1 mediated noncanonical NF-kB signaling | 9 | 1.083677e-09 | 4 |
| REAC | REAC:R-HSA-5610780 | Degradation of GLI1 by the proteasome | Degradation of GLI1 by the proteasome | 9 | 1.083677e-09 | 4 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 9 | 1.083677e-09 | 4 |
| REAC | REAC:R-HSA-5678895 | Defective CFTR causes cystic fibrosis | Defective CFTR causes cystic fibrosis | 9 | 1.267273e-09 | 4 |
| REAC | REAC:R-HSA-4608870 | Asymmetric localization of PCP proteins | Asymmetric localization of PCP proteins | 9 | 1.993793e-09 | 4 |
| REAC | REAC:R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | Autodegradation of Cdh1 by Cdh1:APC/C | 9 | 1.993793e-09 | 4 |
| REAC | REAC:R-HSA-5358346 | Hedgehog ligand biogenesis | Hedgehog ligand biogenesis | 9 | 2.307005e-09 | 4 |
| REAC | REAC:R-HSA-9759194 | Nuclear events mediated by NFE2L2 | Nuclear events mediated by NFE2L2 | 10 | 2.311830e-09 | 4 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 9 | 2.662937e-09 | 4 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 9 | 2.662937e-09 | 4 |
| REAC | REAC:R-HSA-1169091 | Activation of NF-kappaB in B cells | Activation of NF-kappaB in B cells | 9 | 3.066555e-09 | 4 |
| REAC | REAC:R-HSA-5658442 | Regulation of RAS by GAPs | Regulation of RAS by GAPs | 9 | 3.066555e-09 | 4 |
| REAC | REAC:R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | APC/C:Cdc20 mediated degradation of Securin | 9 | 3.523309e-09 | 4 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 9 | 3.523309e-09 | 4 |
| REAC | REAC:R-HSA-8948751 | Regulation of PTEN stability and activity | Regulation of PTEN stability and activity | 9 | 4.039164e-09 | 4 |
| REAC | REAC:R-HSA-9793380 | Formation of paraxial mesoderm | Formation of paraxial mesoderm | 9 | 4.039164e-09 | 4 |
| REAC | REAC:R-HSA-8939902 | Regulation of RUNX2 expression and activity | Regulation of RUNX2 expression and activity | 9 | 5.274874e-09 | 4 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 9 | 5.274874e-09 | 4 |
| REAC | REAC:R-HSA-2467813 | Separation of Sister Chromatids | Separation of Sister Chromatids | 12 | 5.528650e-09 | 4 |
| REAC | REAC:R-HSA-8951664 | Neddylation | Neddylation | 13 | 6.724087e-09 | 4 |
| REAC | REAC:R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 9 | 6.833330e-09 | 4 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 9 | 6.833330e-09 | 4 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 9 | 7.755207e-09 | 4 |
| REAC | REAC:R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 9 | 7.755207e-09 | 4 |
| REAC | REAC:R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | APC/C:Cdc20 mediated degradation of mitotic proteins | 9 | 9.934238e-09 | 4 |
| REAC | REAC:R-HSA-446652 | Interleukin-1 family signaling | Interleukin-1 family signaling | 11 | 1.051647e-08 | 4 |
| REAC | REAC:R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 9 | 1.121396e-08 | 4 |
| REAC | REAC:R-HSA-5617833 | Cilium Assembly | Cilium Assembly | 12 | 1.145737e-08 | 4 |
| REAC | REAC:R-HSA-5619084 | ABC transporter disorders | ABC transporter disorders | 9 | 1.263708e-08 | 4 |
| REAC | REAC:R-HSA-9020702 | Interleukin-1 signaling | Interleukin-1 signaling | 10 | 1.343852e-08 | 4 |
| REAC | REAC:R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | Downstream signaling events of B Cell Receptor (BCR) | 9 | 1.596952e-08 | 4 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 9 | 1.790963e-08 | 4 |
| REAC | REAC:R-HSA-9013694 | Signaling by NOTCH4 | Signaling by NOTCH4 | 9 | 1.790963e-08 | 4 |
| REAC | REAC:R-HSA-5357801 | Programmed Cell Death | Programmed Cell Death | 12 | 1.814912e-08 | 4 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 9 | 2.005486e-08 | 4 |
| REAC | REAC:R-HSA-195253 | Degradation of beta-catenin by the destruction complex | Degradation of beta-catenin by the destruction complex | 9 | 2.242374e-08 | 4 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 9 | 2.503618e-08 | 4 |
| REAC | REAC:R-HSA-68886 | M Phase | M Phase | 15 | 2.677411e-08 | 4 |
| REAC | REAC:R-HSA-5632684 | Hedgehog 'on' state | Hedgehog 'on' state | 9 | 2.791356e-08 | 4 |
| REAC | REAC:R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | Regulation of mRNA stability by proteins that bind AU-rich elements | 9 | 3.107884e-08 | 4 |
| REAC | REAC:R-HSA-9755511 | KEAP1-NFE2L2 pathway | KEAP1-NFE2L2 pathway | 10 | 3.414063e-08 | 4 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 9 | 3.837323e-08 | 4 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 9 | 3.837323e-08 | 4 |
| REAC | REAC:R-HSA-5687128 | MAPK6/MAPK4 signaling | MAPK6/MAPK4 signaling | 9 | 4.255690e-08 | 4 |
| REAC | REAC:R-HSA-1236974 | ER-Phagosome pathway | ER-Phagosome pathway | 9 | 4.713777e-08 | 4 |
| REAC | REAC:R-HSA-68882 | Mitotic Anaphase | Mitotic Anaphase | 12 | 5.295740e-08 | 4 |
| REAC | REAC:R-HSA-2555396 | Mitotic Metaphase and Anaphase | Mitotic Metaphase and Anaphase | 12 | 5.571929e-08 | 4 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 9 | 5.762212e-08 | 4 |
| REAC | REAC:R-HSA-4086400 | PCP/CE pathway | PCP/CE pathway | 9 | 5.762212e-08 | 4 |
| REAC | REAC:R-HSA-8878159 | Transcriptional regulation by RUNX3 | Transcriptional regulation by RUNX3 | 9 | 7.720595e-08 | 4 |
| REAC | REAC:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | CLEC7A (Dectin-1) signaling | 9 | 9.331985e-08 | 4 |
| REAC | REAC:R-HSA-6807070 | PTEN Regulation | PTEN Regulation | 10 | 9.905931e-08 | 4 |
| REAC | REAC:R-HSA-202424 | Downstream TCR signaling | Downstream TCR signaling | 9 | 1.024356e-07 | 4 |
| REAC | REAC:R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | TNFR2 non-canonical NF-kB pathway | 9 | 1.230507e-07 | 4 |
| REAC | REAC:R-HSA-3858494 | Beta-catenin independent WNT signaling | Beta-catenin independent WNT signaling | 10 | 1.409121e-07 | 4 |
| REAC | REAC:R-HSA-382556 | ABC-family proteins mediated transport | ABC-family proteins mediated transport | 9 | 1.608298e-07 | 4 |
| REAC | REAC:R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | BBSome-mediated cargo-targeting to cilium | 6 | 1.708438e-07 | 4 |
| REAC | REAC:R-HSA-9013418 | RHOBTB2 GTPase cycle | RHOBTB2 GTPase cycle | 6 | 1.708438e-07 | 4 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 16 | 1.732324e-07 | 4 |
| REAC | REAC:R-HSA-1236975 | Antigen processing-Cross presentation | Antigen processing-Cross presentation | 9 | 1.913707e-07 | 4 |
| REAC | REAC:R-HSA-392499 | Metabolism of proteins | Metabolism of proteins | 28 | 2.595440e-07 | 4 |
| REAC | REAC:R-HSA-8878166 | Transcriptional regulation by RUNX2 | Transcriptional regulation by RUNX2 | 9 | 5.466666e-07 | 4 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 18 | 6.163496e-07 | 4 |
| REAC | REAC:R-HSA-202403 | TCR signaling | TCR signaling | 9 | 6.353517e-07 | 4 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 9 | 6.842598e-07 | 4 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 18 | 8.153890e-07 | 4 |
| REAC | REAC:R-HSA-1852241 | Organelle biogenesis and maintenance | Organelle biogenesis and maintenance | 12 | 8.742168e-07 | 4 |
| REAC | REAC:R-HSA-9758941 | Gastrulation | Gastrulation | 9 | 9.146095e-07 | 4 |
| REAC | REAC:R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | Diseases of signal transduction by growth factor receptors and second messengers | 14 | 1.021279e-06 | 4 |
| REAC | REAC:R-HSA-162909 | Host Interactions of HIV factors | Host Interactions of HIV factors | 9 | 1.053465e-06 | 4 |
| REAC | REAC:R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 9 | 1.210514e-06 | 4 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 9 | 1.387768e-06 | 4 |
| REAC | REAC:R-HSA-422475 | Axon guidance | Axon guidance | 15 | 1.470018e-06 | 4 |
| REAC | REAC:R-HSA-2871837 | FCERI mediated NF-kB activation | FCERI mediated NF-kB activation | 9 | 1.934201e-06 | 4 |
| REAC | REAC:R-HSA-5621481 | C-type lectin receptors (CLRs) | C-type lectin receptors (CLRs) | 9 | 1.934201e-06 | 4 |
| REAC | REAC:R-HSA-9706574 | RHOBTB GTPase Cycle | RHOBTB GTPase Cycle | 6 | 2.643522e-06 | 4 |
| REAC | REAC:R-HSA-9675108 | Nervous system development | Nervous system development | 15 | 2.712710e-06 | 4 |
| REAC | REAC:R-HSA-68867 | Assembly of the pre-replicative complex | Assembly of the pre-replicative complex | 9 | 2.832312e-06 | 4 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 16 | 3.772899e-06 | 4 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 9 | 4.077318e-06 | 4 |
| REAC | REAC:R-HSA-9711123 | Cellular response to chemical stress | Cellular response to chemical stress | 10 | 5.930245e-06 | 4 |
| REAC | REAC:R-HSA-69002 | DNA Replication Pre-Initiation | DNA Replication Pre-Initiation | 9 | 7.641761e-06 | 4 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 9 | 8.996069e-06 | 4 |
| REAC | REAC:R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | Signaling by the B Cell Receptor (BCR) | 9 | 9.491969e-06 | 4 |
| REAC | REAC:R-HSA-69481 | G2/M Checkpoints | G2/M Checkpoints | 9 | 1.172308e-05 | 4 |
| REAC | REAC:R-HSA-5688426 | Deubiquitination | Deubiquitination | 11 | 1.431819e-05 | 4 |
| REAC | REAC:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Regulation of expression of SLITs and ROBOs | 9 | 1.440024e-05 | 4 |
| REAC | REAC:R-HSA-5619115 | Disorders of transmembrane transporters | Disorders of transmembrane transporters | 9 | 1.592887e-05 | 4 |
| REAC | REAC:R-HSA-109581 | Apoptosis | Apoptosis | 9 | 1.848775e-05 | 4 |
| REAC | REAC:R-HSA-449147 | Signaling by Interleukins | Signaling by Interleukins | 13 | 2.360498e-05 | 4 |
| REAC | REAC:R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | Fc epsilon receptor (FCERI) signaling | 9 | 2.470306e-05 | 4 |
| REAC | REAC:R-HSA-1280215 | Cytokine Signaling in Immune system | Cytokine Signaling in Immune system | 16 | 2.673763e-05 | 4 |
| REAC | REAC:R-HSA-5620920 | Cargo trafficking to the periciliary membrane | Cargo trafficking to the periciliary membrane | 6 | 2.786592e-05 | 4 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 9 | 3.120534e-05 | 4 |
| REAC | REAC:R-HSA-1257604 | PIP3 activates AKT signaling | PIP3 activates AKT signaling | 10 | 3.343846e-05 | 4 |
| REAC | REAC:R-HSA-376176 | Signaling by ROBO receptors | Signaling by ROBO receptors | 9 | 1.113551e-04 | 4 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 16 | 1.266833e-04 | 4 |
| REAC | REAC:R-HSA-5689880 | Ub-specific processing proteases | Ub-specific processing proteases | 9 | 1.300092e-04 | 4 |
| REAC | REAC:R-HSA-9006925 | Intracellular signaling by second messengers | Intracellular signaling by second messengers | 10 | 1.321085e-04 | 4 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 9 | 1.571046e-04 | 4 |
| REAC | REAC:R-HSA-162582 | Signal Transduction | Signal Transduction | 27 | 1.866967e-04 | 4 |
| REAC | REAC:R-HSA-157118 | Signaling by NOTCH | Signaling by NOTCH | 9 | 1.889811e-04 | 4 |
| REAC | REAC:R-HSA-201681 | TCF dependent signaling in response to WNT | TCF dependent signaling in response to WNT | 9 | 1.889811e-04 | 4 |
| REAC | REAC:R-HSA-8878171 | Transcriptional regulation by RUNX1 | Transcriptional regulation by RUNX1 | 9 | 2.106877e-04 | 4 |
| REAC | REAC:R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | Antigen processing: Ubiquitination & Proteasome degradation | 10 | 2.160338e-04 | 4 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 17 | 3.281928e-04 | 4 |
| REAC | REAC:R-HSA-195721 | Signaling by WNT | Signaling by WNT | 10 | 3.737084e-04 | 4 |
| REAC | REAC:R-HSA-5673001 | RAF/MAP kinase cascade | RAF/MAP kinase cascade | 9 | 6.152469e-04 | 4 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 22 | 6.287896e-04 | 4 |
| REAC | REAC:R-HSA-5684996 | MAPK1/MAPK3 signaling | MAPK1/MAPK3 signaling | 9 | 7.179521e-04 | 4 |
| REAC | REAC:R-HSA-71291 | Metabolism of amino acids and derivatives | Metabolism of amino acids and derivatives | 10 | 9.623958e-04 | 4 |
| REAC | REAC:R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Recruitment of NuMA to mitotic centrosomes | 6 | 1.097745e-03 | 4 |
| REAC | REAC:R-HSA-9612973 | Autophagy | Autophagy | 7 | 1.186806e-03 | 4 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 9 | 1.220238e-03 | 4 |
| REAC | REAC:R-HSA-597592 | Post-translational protein modification | Post-translational protein modification | 19 | 1.239209e-03 | 4 |
| REAC | REAC:R-HSA-168256 | Immune System | Immune System | 23 | 1.265294e-03 | 4 |
| REAC | REAC:R-HSA-983169 | Class I MHC mediated antigen processing & presentation | Class I MHC mediated antigen processing & presentation | 10 | 1.450421e-03 | 4 |
| REAC | REAC:R-HSA-6798695 | Neutrophil degranulation | Neutrophil degranulation | 11 | 1.534377e-03 | 4 |
| REAC | REAC:R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | 5 | 1.660371e-03 | 4 |
| REAC | REAC:R-HSA-1280218 | Adaptive Immune System | Adaptive Immune System | 14 | 1.734312e-03 | 4 |
| REAC | REAC:R-HSA-5683057 | MAPK family signaling cascades | MAPK family signaling cascades | 9 | 2.165415e-03 | 4 |
| REAC | REAC:R-HSA-168249 | Innate Immune System | Innate Immune System | 16 | 2.745999e-03 | 4 |
| REAC | REAC:R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | Assembly and release of respiratory syncytial virus (RSV) virions | 2 | 7.318198e-03 | 4 |
| REAC | REAC:R-HSA-9834752 | Respiratory syncytial virus genome replication | Respiratory syncytial virus genome replication | 2 | 7.318198e-03 | 4 |
| REAC | REAC:R-HSA-1632852 | Macroautophagy | Macroautophagy | 6 | 8.513491e-03 | 4 |
| REAC | REAC:R-HSA-9663891 | Selective autophagy | Selective autophagy | 5 | 8.859763e-03 | 4 |
| REAC | REAC:R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | Assembly and cell surface presentation of NMDA receptors | 4 | 1.307741e-02 | 4 |
| REAC | REAC:R-HSA-9646399 | Aggrephagy | Aggrephagy | 4 | 1.434027e-02 | 4 |
| REAC | REAC:R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 3 | 3.242594e-02 | 4 |
| REAC | REAC:R-HSA-190872 | Transport of connexons to the plasma membrane | Transport of connexons to the plasma membrane | 3 | 3.771703e-02 | 4 |
| REAC | REAC:R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | Resistance of ERBB2 KD mutants to neratinib | 2 | 4.367009e-02 | 4 |
| REAC | REAC:R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | Resistance of ERBB2 KD mutants to afatinib | 2 | 4.367009e-02 | 4 |
| REAC | REAC:R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | Resistance of ERBB2 KD mutants to sapitinib | 2 | 4.367009e-02 | 4 |
| REAC | REAC:R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | Drug-mediated inhibition of ERBB2 signaling | 2 | 4.367009e-02 | 4 |
| REAC | REAC:R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | Drug resistance in ERBB2 TMD/JMD mutants | 2 | 4.367009e-02 | 4 |
| REAC | REAC:R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | Drug resistance in ERBB2 KD mutants | 2 | 4.367009e-02 | 4 |
| REAC | REAC:R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | Resistance of ERBB2 KD mutants to osimertinib | 2 | 4.367009e-02 | 4 |
| REAC | REAC:R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | Resistance of ERBB2 KD mutants to tesevatinib | 2 | 4.367009e-02 | 4 |
| REAC | REAC:R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | Resistance of ERBB2 KD mutants to trastuzumab | 2 | 4.367009e-02 | 4 |
| REAC | REAC:R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | Resistance of ERBB2 KD mutants to lapatinib | 2 | 4.367009e-02 | 4 |
| REAC | REAC:R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | Resistance of ERBB2 KD mutants to AEE788 | 2 | 4.367009e-02 | 4 |
| REAC | REAC:R-HSA-389977 | Post-chaperonin tubulin folding pathway | Post-chaperonin tubulin folding pathway | 3 | 4.992306e-02 | 4 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005832 | chaperonin-containing T-complex | "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] | 8 | 9.417159e-18 | 4 |
| GO:CC | GO:0101031 | protein folding chaperone complex | "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] | 10 | 9.807596e-16 | 4 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 23 | 3.077195e-15 | 4 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 38 | 4.242705e-14 | 4 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 43 | 4.315326e-14 | 4 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 28 | 1.602474e-12 | 4 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 28 | 2.294230e-12 | 4 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 28 | 2.321611e-12 | 4 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 28 | 2.321611e-12 | 4 |
| GO:CC | GO:0000502 | proteasome complex | "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome] | 9 | 1.710360e-11 | 4 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 54 | 2.489368e-10 | 4 |
| GO:CC | GO:1905369 | endopeptidase complex | "A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 9 | 7.837689e-10 | 4 |
| GO:CC | GO:0002199 | zona pellucida receptor complex | "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732] | 5 | 1.079902e-09 | 4 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 30 | 2.551424e-09 | 4 |
| GO:CC | GO:0005874 | microtubule | "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] | 14 | 2.776926e-09 | 4 |
| GO:CC | GO:0005838 | proteasome regulatory particle | "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 6 | 3.169464e-09 | 4 |
| GO:CC | GO:0022624 | proteasome accessory complex | "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu] | 6 | 7.480253e-09 | 4 |
| GO:CC | GO:1905368 | peptidase complex | "A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] | 9 | 7.825546e-09 | 4 |
| GO:CC | GO:0044297 | cell body | "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] | 14 | 1.860944e-08 | 4 |
| GO:CC | GO:0005576 | extracellular region | "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] | 32 | 4.620390e-08 | 4 |
| GO:CC | GO:0034774 | secretory granule lumen | "The volume enclosed by the membrane of a secretory granule." [GOC:rph] | 11 | 8.953539e-08 | 4 |
| GO:CC | GO:0060205 | cytoplasmic vesicle lumen | "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] | 11 | 1.053261e-07 | 4 |
| GO:CC | GO:0031983 | vesicle lumen | "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] | 11 | 1.087692e-07 | 4 |
| GO:CC | GO:1904813 | ficolin-1-rich granule lumen | "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] | 8 | 1.857189e-07 | 4 |
| GO:CC | GO:0099512 | supramolecular fiber | "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] | 16 | 9.521022e-07 | 4 |
| GO:CC | GO:0099081 | supramolecular polymer | "A polymeric supramolecular structure." [GOC:dos] | 16 | 1.059037e-06 | 4 |
| GO:CC | GO:0015630 | microtubule cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] | 18 | 1.311359e-06 | 4 |
| GO:CC | GO:0099513 | polymeric cytoskeletal fiber | "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] | 14 | 2.205383e-06 | 4 |
| GO:CC | GO:0031410 | cytoplasmic vesicle | "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] | 23 | 2.801267e-06 | 4 |
| GO:CC | GO:0097708 | intracellular vesicle | "Any vesicle that is part of the intracellular region." [GOC:vesicles] | 23 | 2.929887e-06 | 4 |
| GO:CC | GO:0101002 | ficolin-1-rich granule | "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] | 8 | 4.205271e-06 | 4 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 54 | 4.468266e-05 | 4 |
| GO:CC | GO:0030141 | secretory granule | "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] | 13 | 6.080325e-05 | 4 |
| GO:CC | GO:0099080 | supramolecular complex | "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] | 16 | 6.607777e-05 | 4 |
| GO:CC | GO:0008541 | proteasome regulatory particle, lid subcomplex | "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb] | 3 | 1.990713e-04 | 4 |
| GO:CC | GO:0099503 | secretory vesicle | "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] | 13 | 5.281893e-04 | 4 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 26 | 5.505422e-04 | 4 |
| GO:CC | GO:0008540 | proteasome regulatory particle, base subcomplex | "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] | 3 | 7.765742e-04 | 4 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 19 | 9.908824e-04 | 4 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 16 | 1.010082e-03 | 4 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 33 | 1.117635e-03 | 4 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 33 | 1.117635e-03 | 4 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 33 | 1.117635e-03 | 4 |
| GO:CC | GO:1990565 | HSP90-CDC37 chaperone complex | "A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins." [GOC:bhm, GOC:pad, GOC:PARL, PMID:21855797, PMID:22939624] | 2 | 1.498602e-03 | 4 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 54 | 1.696807e-03 | 4 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 36 | 1.963331e-03 | 4 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 55 | 2.279635e-03 | 4 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 29 | 2.361333e-03 | 4 |
| GO:CC | GO:0005839 | proteasome core complex | "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] | 3 | 6.131521e-03 | 4 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 52 | 1.081992e-02 | 4 |
| GO:CC | GO:0035578 | azurophil granule lumen | "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] | 4 | 1.917544e-02 | 4 |
| GO:CC | GO:0005775 | vacuolar lumen | "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] | 5 | 2.077634e-02 | 4 |
| GO:CC | GO:0005929 | cilium | "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] | 9 | 3.193351e-02 | 4 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0140662 | ATP-dependent protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] | 10 | 1.809013e-16 | 4 |
| GO:MF | GO:0051082 | unfolded protein binding | "Binding to an unfolded protein." [GOC:ai] | 12 | 8.337254e-14 | 4 |
| GO:MF | GO:0044183 | protein folding chaperone | "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] | 10 | 1.100263e-12 | 4 |
| GO:MF | GO:0035639 | purine ribonucleoside triphosphate binding | "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] | 26 | 1.584552e-09 | 4 |
| GO:MF | GO:0043168 | anion binding | "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] | 28 | 1.096028e-08 | 4 |
| GO:MF | GO:0032555 | purine ribonucleotide binding | "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 25 | 2.263301e-08 | 4 |
| GO:MF | GO:1901363 | heterocyclic compound binding | "Binding to heterocyclic compound." [GOC:TermGenie] | 27 | 2.381914e-08 | 4 |
| GO:MF | GO:0032553 | ribonucleotide binding | "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 25 | 2.686554e-08 | 4 |
| GO:MF | GO:1901265 | nucleoside phosphate binding | "Binding to nucleoside phosphate." [GOC:TermGenie] | 26 | 4.727380e-08 | 4 |
| GO:MF | GO:0017076 | purine nucleotide binding | "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] | 25 | 5.727574e-08 | 4 |
| GO:MF | GO:0097367 | carbohydrate derivative binding | "Binding to a carbohydrate derivative." [GOC:pr] | 26 | 1.293046e-07 | 4 |
| GO:MF | GO:0000166 | nucleotide binding | "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] | 25 | 2.625689e-07 | 4 |
| GO:MF | GO:0016887 | ATP hydrolysis activity | "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] | 12 | 3.856839e-07 | 4 |
| GO:MF | GO:0005524 | ATP binding | "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] | 20 | 4.987315e-07 | 4 |
| GO:MF | GO:0032559 | adenyl ribonucleotide binding | "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] | 20 | 8.026795e-07 | 4 |
| GO:MF | GO:0003824 | catalytic activity | "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] | 40 | 1.668703e-06 | 4 |
| GO:MF | GO:0030554 | adenyl nucleotide binding | "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] | 20 | 2.186223e-06 | 4 |
| GO:MF | GO:0017111 | ribonucleoside triphosphate phosphatase activity | "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] | 16 | 3.250917e-05 | 4 |
| GO:MF | GO:0140657 | ATP-dependent activity | "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] | 12 | 4.138830e-05 | 4 |
| GO:MF | GO:0016462 | pyrophosphatase activity | "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] | 16 | 6.355560e-05 | 4 |
| GO:MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] | 16 | 6.424895e-05 | 4 |
| GO:MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] | 16 | 6.424895e-05 | 4 |
| GO:MF | GO:0016787 | hydrolase activity | "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] | 25 | 1.296424e-04 | 4 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 54 | 9.562940e-04 | 4 |
| GO:MF | GO:0005200 | structural constituent of cytoskeleton | "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] | 5 | 6.667345e-03 | 4 |
| GO:MF | GO:0031625 | ubiquitin protein ligase binding | "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] | 7 | 8.489256e-03 | 4 |
| GO:MF | GO:0036094 | small molecule binding | "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] | 33 | 1.141379e-02 | 4 |
| GO:MF | GO:0044389 | ubiquitin-like protein ligase binding | "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] | 7 | 1.224709e-02 | 4 |
| GO:MF | GO:0043167 | ion binding | "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] | 32 | 1.793702e-02 | 4 |
| GO:MF | GO:0004672 | protein kinase activity | "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] | 10 | 2.038773e-02 | 4 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 4 | 2.254466e-02 | 4 |
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 4 | 2.254466e-02 | 4 |
| GO:MF | GO:0140096 | catalytic activity, acting on a protein | "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] | 19 | 4.977798e-02 | 4 |
| GO:MF | GO:0036402 | proteasome-activating activity | "Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome." [GOC:rb, PMID:11430818] | 2 | 4.996928e-02 | 4 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:126 | CCT complex (chaperonin containing TCP1 complex) | CCT complex (chaperonin containing TCP1 complex) | 8 | 1.139895e-14 | 4 |
| CORUM | CORUM:193 | PA700-20S-PA28 complex | PA700-20S-PA28 complex | 9 | 2.600401e-09 | 4 |
| CORUM | CORUM:6247 | BBS-chaperonin complex | BBS-chaperonin complex | 6 | 4.434104e-08 | 4 |
| CORUM | CORUM:32 | PA700 complex | PA700 complex | 6 | 7.678831e-06 | 4 |
| CORUM | CORUM:181 | 26S proteasome | 26S proteasome | 5 | 2.990179e-04 | 4 |
| CORUM | CORUM:2112 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex | 3 | 1.689934e-03 | 4 |
| CORUM | CORUM:5234 | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex | 3 | 4.198590e-03 | 4 |
| CORUM | CORUM:5269 | TNF-alpha/NF-kappa B signaling complex 8 | TNF-alpha/NF-kappa B signaling complex 8 | 3 | 8.345026e-03 | 4 |
| CORUM | CORUM:5268 | TNF-alpha/NF-kappa B signaling complex 7 | TNF-alpha/NF-kappa B signaling complex 7 | 3 | 2.307681e-02 | 4 |
| CORUM | CORUM:5212 | Kinase maturation complex 2 | Kinase maturation complex 2 | 3 | 2.307681e-02 | 4 |
| CORUM | CORUM:5286 | TNF-alpha/NF-kappa B signaling complex 10 | TNF-alpha/NF-kappa B signaling complex 10 | 3 | 4.883836e-02 | 4 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis | 16 | 4.221556e-12 | 4 |
| KEGG | KEGG:03050 | Proteasome | Proteasome | 9 | 4.773265e-12 | 4 |
| KEGG | KEGG:05020 | Prion disease | Prion disease | 14 | 3.027447e-11 | 4 |
| KEGG | KEGG:05010 | Alzheimer disease | Alzheimer disease | 15 | 1.843295e-10 | 4 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | Pathways of neurodegeneration - multiple diseases | 16 | 2.622648e-10 | 4 |
| KEGG | KEGG:05012 | Parkinson disease | Parkinson disease | 13 | 5.092709e-10 | 4 |
| KEGG | KEGG:05016 | Huntington disease | Huntington disease | 13 | 3.011288e-09 | 4 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | Spinocerebellar ataxia | 10 | 6.013549e-09 | 4 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 6 | 7.565388e-03 | 4 |
| KEGG | KEGG:05132 | Salmonella infection | Salmonella infection | 6 | 2.641186e-02 | 4 |
| KEGG | KEGG:04540 | Gap junction | Gap junction | 4 | 2.712008e-02 | 4 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP2359 | Parkin ubiquitin proteasomal system pathway | Parkin ubiquitin proteasomal system pathway | 10 | 3.184895e-10 | 4 |
| WP | WP:WP183 | Proteasome degradation | Proteasome degradation | 9 | 3.395981e-09 | 4 |
| WP | WP:WP5124 | Alzheimer 39 s disease | Alzheimer 39 s disease | 14 | 4.645837e-09 | 4 |
| WP | WP:WP2059 | Alzheimer 39 s disease and miRNA effects | Alzheimer 39 s disease and miRNA effects | 14 | 6.001271e-09 | 4 |
| WP | WP:WP4949 | 16p11 2 proximal deletion syndrome | 16p11 2 proximal deletion syndrome | 8 | 6.832920e-07 | 4 |
| WP | WP:WP2272 | Pathogenic Escherichia coli infection | Pathogenic Escherichia coli infection | 4 | 2.881258e-02 | 4 |
| WP | WP:WP5426 | HDAC6 interactions in the central nervous system | HDAC6 interactions in the central nervous system | 5 | 4.356123e-02 | 4 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0100131 | Cerebral cortex; neuronal cells[≥Low] | Cerebral cortex; neuronal cells[≥Low] | 41 | 0.000045 | 4 |
| HPA | HPA:0020052 | Adrenal gland; glandular cells[≥Medium] | Adrenal gland; glandular cells[≥Medium] | 39 | 0.000069 | 4 |
| HPA | HPA:0180052 | Epididymis; glandular cells[≥Medium] | Epididymis; glandular cells[≥Medium] | 38 | 0.000075 | 4 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 41 | 0.000080 | 4 |
| HPA | HPA:0160051 | Endometrium 1; glandular cells[≥Low] | Endometrium 1; glandular cells[≥Low] | 41 | 0.000083 | 4 |
| HPA | HPA:0530721 | Spleen; cells in white pulp[≥Low] | Spleen; cells in white pulp[≥Low] | 33 | 0.000148 | 4 |
| HPA | HPA:0080131 | Caudate; neuronal cells[≥Low] | Caudate; neuronal cells[≥Low] | 39 | 0.000158 | 4 |
| HPA | HPA:0020051 | Adrenal gland; glandular cells[≥Low] | Adrenal gland; glandular cells[≥Low] | 42 | 0.000178 | 4 |
| HPA | HPA:0020000 | Adrenal gland | Adrenal gland | 42 | 0.000185 | 4 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 39 | 0.000223 | 4 |
| HPA | HPA:0210000 | Fallopian tube | Fallopian tube | 42 | 0.000243 | 4 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 31 | 0.000285 | 4 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 31 | 0.000285 | 4 |
| HPA | HPA:0160000 | Endometrium 1 | Endometrium 1 | 41 | 0.000306 | 4 |
| HPA | HPA:0610832 | Urinary bladder; urothelial cells[≥Medium] | Urinary bladder; urothelial cells[≥Medium] | 38 | 0.000339 | 4 |
| HPA | HPA:0600431 | Tonsil; germinal center cells[≥Low] | Tonsil; germinal center cells[≥Low] | 38 | 0.000408 | 4 |
| HPA | HPA:0170051 | Endometrium 2; glandular cells[≥Low] | Endometrium 2; glandular cells[≥Low] | 40 | 0.000449 | 4 |
| HPA | HPA:0630051 | Cervix; glandular cells[≥Low] | Cervix; glandular cells[≥Low] | 37 | 0.000471 | 4 |
| HPA | HPA:0050000 | Breast | Breast | 41 | 0.000600 | 4 |
| HPA | HPA:0340000 | Ovary | Ovary | 36 | 0.000627 | 4 |
| HPA | HPA:0320000 | Nasopharynx | Nasopharynx | 41 | 0.000656 | 4 |
| HPA | HPA:0170052 | Endometrium 2; glandular cells[≥Medium] | Endometrium 2; glandular cells[≥Medium] | 34 | 0.000750 | 4 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 31 | 0.000764 | 4 |
| HPA | HPA:0600441 | Tonsil; non-germinal center cells[≥Low] | Tonsil; non-germinal center cells[≥Low] | 38 | 0.000836 | 4 |
| HPA | HPA:0030052 | Appendix; glandular cells[≥Medium] | Appendix; glandular cells[≥Medium] | 36 | 0.000896 | 4 |
| HPA | HPA:0130242 | Colon; peripheral nerve/ganglion[≥Medium] | Colon; peripheral nerve/ganglion[≥Medium] | 28 | 0.000977 | 4 |
| HPA | HPA:0170000 | Endometrium 2 | Endometrium 2 | 40 | 0.001230 | 4 |
| HPA | HPA:0350472 | Pancreas; exocrine glandular cells[≥Medium] | Pancreas; exocrine glandular cells[≥Medium] | 35 | 0.001524 | 4 |
| HPA | HPA:0080000 | Caudate | Caudate | 40 | 0.001564 | 4 |
| HPA | HPA:0250132 | Hippocampus; neuronal cells[≥Medium] | Hippocampus; neuronal cells[≥Medium] | 31 | 0.001574 | 4 |
| HPA | HPA:0130051 | Colon; glandular cells[≥Low] | Colon; glandular cells[≥Low] | 40 | 0.001830 | 4 |
| HPA | HPA:0050091 | Breast; myoepithelial cells[≥Low] | Breast; myoepithelial cells[≥Low] | 36 | 0.002061 | 4 |
| HPA | HPA:0060000 | Bronchus | Bronchus | 41 | 0.002176 | 4 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 40 | 0.002204 | 4 |
| HPA | HPA:0400051 | Rectum; glandular cells[≥Low] | Rectum; glandular cells[≥Low] | 40 | 0.002560 | 4 |
| HPA | HPA:0150051 | Duodenum; glandular cells[≥Low] | Duodenum; glandular cells[≥Low] | 40 | 0.003169 | 4 |
| HPA | HPA:0510000 | Soft tissue 2 | Soft tissue 2 | 34 | 0.004048 | 4 |
| HPA | HPA:0360052 | Parathyroid gland; glandular cells[≥Medium] | Parathyroid gland; glandular cells[≥Medium] | 31 | 0.004283 | 4 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 39 | 0.005019 | 4 |
| HPA | HPA:0100132 | Cerebral cortex; neuronal cells[≥Medium] | Cerebral cortex; neuronal cells[≥Medium] | 33 | 0.005576 | 4 |
| HPA | HPA:0100000 | Cerebral cortex | Cerebral cortex | 42 | 0.006299 | 4 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 29 | 0.006488 | 4 |
| HPA | HPA:0130241 | Colon; peripheral nerve/ganglion[≥Low] | Colon; peripheral nerve/ganglion[≥Low] | 33 | 0.007106 | 4 |
| HPA | HPA:0630000 | Cervix | Cervix | 39 | 0.007917 | 4 |
| HPA | HPA:0610000 | Urinary bladder | Urinary bladder | 40 | 0.008078 | 4 |
| HPA | HPA:0610831 | Urinary bladder; urothelial cells[≥Low] | Urinary bladder; urothelial cells[≥Low] | 40 | 0.008078 | 4 |
| HPA | HPA:0330000 | Oral mucosa | Oral mucosa | 37 | 0.008357 | 4 |
| HPA | HPA:0330221 | Oral mucosa; squamous epithelial cells[≥Low] | Oral mucosa; squamous epithelial cells[≥Low] | 37 | 0.008357 | 4 |
| HPA | HPA:0550052 | Stomach 2; glandular cells[≥Medium] | Stomach 2; glandular cells[≥Medium] | 37 | 0.009410 | 4 |
| HPA | HPA:0180051 | Epididymis; glandular cells[≥Low] | Epididymis; glandular cells[≥Low] | 40 | 0.009580 | 4 |
| HPA | HPA:0180000 | Epididymis | Epididymis | 40 | 0.009580 | 4 |
| HPA | HPA:0080121 | Caudate; glial cells[≥Low] | Caudate; glial cells[≥Low] | 31 | 0.010376 | 4 |
| HPA | HPA:0600221 | Tonsil; squamous epithelial cells[≥Low] | Tonsil; squamous epithelial cells[≥Low] | 38 | 0.011191 | 4 |
| HPA | HPA:0540052 | Stomach 1; glandular cells[≥Medium] | Stomach 1; glandular cells[≥Medium] | 37 | 0.012949 | 4 |
| HPA | HPA:0630221 | Cervix; squamous epithelial cells[≥Low] | Cervix; squamous epithelial cells[≥Low] | 34 | 0.013807 | 4 |
| HPA | HPA:0210052 | Fallopian tube; glandular cells[≥Medium] | Fallopian tube; glandular cells[≥Medium] | 31 | 0.016889 | 4 |
| HPA | HPA:0600222 | Tonsil; squamous epithelial cells[≥Medium] | Tonsil; squamous epithelial cells[≥Medium] | 32 | 0.017041 | 4 |
| HPA | HPA:0030051 | Appendix; glandular cells[≥Low] | Appendix; glandular cells[≥Low] | 38 | 0.017847 | 4 |
| HPA | HPA:0130000 | Colon | Colon | 42 | 0.019385 | 4 |
| HPA | HPA:0270362 | Kidney; cells in tubules[≥Medium] | Kidney; cells in tubules[≥Medium] | 35 | 0.019787 | 4 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 39 | 0.020058 | 4 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 39 | 0.020058 | 4 |
| HPA | HPA:0150000 | Duodenum | Duodenum | 41 | 0.020272 | 4 |
| HPA | HPA:0320102 | Nasopharynx; respiratory epithelial cells[≥Medium] | Nasopharynx; respiratory epithelial cells[≥Medium] | 31 | 0.023569 | 4 |
| HPA | HPA:0530000 | Spleen | Spleen | 35 | 0.028092 | 4 |
| HPA | HPA:0400000 | Rectum | Rectum | 41 | 0.028349 | 4 |
| HPA | HPA:0351181 | Pancreas; pancreatic endocrine cells[≥Low] | Pancreas; pancreatic endocrine cells[≥Low] | 34 | 0.030072 | 4 |
| HPA | HPA:0550000 | Stomach 2 | Stomach 2 | 40 | 0.033144 | 4 |
| HPA | HPA:0550051 | Stomach 2; glandular cells[≥Low] | Stomach 2; glandular cells[≥Low] | 40 | 0.033144 | 4 |
| HPA | HPA:0460000 | Skin 1 | Skin 1 | 39 | 0.033916 | 4 |
| HPA | HPA:0420000 | Salivary gland | Salivary gland | 38 | 0.034981 | 4 |
| HPA | HPA:0420051 | Salivary gland; glandular cells[≥Low] | Salivary gland; glandular cells[≥Low] | 38 | 0.034981 | 4 |
| HPA | HPA:0530722 | Spleen; cells in white pulp[≥Medium] | Spleen; cells in white pulp[≥Medium] | 22 | 0.035093 | 4 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 32 | 0.036223 | 4 |
| HPA | HPA:0130201 | Colon; endothelial cells[≥Low] | Colon; endothelial cells[≥Low] | 34 | 0.038138 | 4 |
| HPA | HPA:0220051 | Gallbladder; glandular cells[≥Low] | Gallbladder; glandular cells[≥Low] | 40 | 0.041586 | 4 |
| HPA | HPA:0220000 | Gallbladder | Gallbladder | 40 | 0.041586 | 4 |
| HPA | HPA:0350471 | Pancreas; exocrine glandular cells[≥Low] | Pancreas; exocrine glandular cells[≥Low] | 38 | 0.041871 | 4 |
| HPA | HPA:0090162 | Cerebellum; Purkinje cells[≥Medium] | Cerebellum; Purkinje cells[≥Medium] | 28 | 0.044559 | 4 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-186-5p | hsa-mir-186-5p | hsa-mir-186-5p | 13 | 0.000245 | 4 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 15 | 0.008713 | 4 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M02053 | Factor: ELF1; motif: NCCGGAARTN | Factor: ELF1; motif: NCCGGAARTN | 34 | 0.004444 | 4 |
| TF | TF:M02074 | Factor: GABPalpha; motif: RCCGGAWRYN | Factor: GABPalpha; motif: RCCGGAWRYN | 29 | 0.005637 | 4 |
| TF | TF:M02056 | Factor: ELF4; motif: NCCGGAARTN | Factor: ELF4; motif: NCCGGAARTN | 31 | 0.011253 | 4 |
| TF | TF:M11400 | Factor: Fli-1; motif: NACCGGAARTN | Factor: Fli-1; motif: NACCGGAARTN | 44 | 0.016736 | 4 |
| TF | TF:M08423 | Factor: TEF-3:ER81; motif: ACCGGAAATRCC | Factor: TEF-3:ER81; motif: ACCGGAAATRCC | 25 | 0.028971 | 4 |
| TF | TF:M02071 | Factor: ETV7; motif: NCCGGAANNN | Factor: ETV7; motif: NCCGGAANNN | 44 | 0.030776 | 4 |
| TF | TF:M03988 | Factor: FLI1; motif: ACCGGAARTN | Factor: FLI1; motif: ACCGGAARTN | 39 | 0.041199 | 4 |
| TF | TF:M11392 | Factor: Erg; motif: NACCGGAARYN | Factor: Erg; motif: NACCGGAARYN | 40 | 0.042750 | 4 |
Community 5
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP411 | mRNA processing | mRNA processing | 13 | 3.530784e-13 | 5 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0043484 | regulation of RNA splicing | "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] | 13 | 4.729747e-13 | 5 |
| GO:BP | GO:0000380 | alternative mRNA splicing, via spliceosome | "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] | 9 | 1.037644e-10 | 5 |
| GO:BP | GO:0008380 | RNA splicing | "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] | 22 | 3.699598e-08 | 5 |
| GO:BP | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] | 7 | 7.417576e-08 | 5 |
| GO:BP | GO:0016071 | mRNA metabolic process | "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] | 23 | 9.395285e-08 | 5 |
| GO:BP | GO:0048024 | regulation of mRNA splicing, via spliceosome | "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] | 8 | 3.152991e-07 | 5 |
| GO:BP | GO:0050684 | regulation of mRNA processing | "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] | 8 | 1.329803e-06 | 5 |
| GO:BP | GO:1903311 | regulation of mRNA metabolic process | "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 10 | 3.679624e-06 | 5 |
| GO:BP | GO:0006397 | mRNA processing | "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] | 20 | 3.755265e-06 | 5 |
| GO:BP | GO:0000375 | RNA splicing, via transesterification reactions | "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] | 18 | 3.224364e-05 | 5 |
| GO:BP | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] | 17 | 2.045454e-04 | 5 |
| GO:BP | GO:0000398 | mRNA splicing, via spliceosome | "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] | 17 | 2.045454e-04 | 5 |
| GO:BP | GO:0006396 | RNA processing | "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] | 23 | 4.943746e-04 | 5 |
| GO:BP | GO:0097167 | circadian regulation of translation | "Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours." [GOC:ans, PMID:17264215] | 2 | 8.867341e-03 | 5 |
| GO:BP | GO:0071383 | cellular response to steroid hormone stimulus | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah] | 6 | 1.632444e-02 | 5 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] | 33 | 4.939592e-02 | 5 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0003723 | RNA binding | "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] | 32 | 1.345812e-12 | 5 |
| GO:MF | GO:0003676 | nucleic acid binding | "Binding to a nucleic acid." [GOC:jl] | 36 | 6.097029e-09 | 5 |
| GO:MF | GO:0003729 | mRNA binding | "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] | 12 | 4.813228e-08 | 5 |
| GO:MF | GO:0045296 | cadherin binding | "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 9 | 4.437438e-05 | 5 |
| GO:MF | GO:0003730 | mRNA 3'-UTR binding | "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] | 6 | 1.483512e-04 | 5 |
| GO:MF | GO:0003727 | single-stranded RNA binding | "Binding to single-stranded RNA." [GOC:jl] | 5 | 8.840856e-04 | 5 |
| GO:MF | GO:0050839 | cell adhesion molecule binding | "Binding to a cell adhesion molecule." [GOC:ai] | 9 | 3.337150e-03 | 5 |
| GO:MF | GO:0005515 | protein binding | "Binding to a protein." [GOC:go_curators] | 48 | 4.959214e-03 | 5 |
| GO:MF | GO:0003724 | RNA helicase activity | "Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098] | 4 | 1.582105e-02 | 5 |
| GO:MF | GO:0008186 | ATP-dependent activity, acting on RNA | "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl] | 4 | 1.752766e-02 | 5 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-72163 | mRNA Splicing - Major Pathway | mRNA Splicing - Major Pathway | 14 | 3.721424e-12 | 5 |
| REAC | REAC:R-HSA-72172 | mRNA Splicing | mRNA Splicing | 14 | 5.988954e-12 | 5 |
| REAC | REAC:R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | Processing of Capped Intron-Containing Pre-mRNA | 14 | 2.787927e-10 | 5 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 18 | 8.732913e-09 | 5 |
| REAC | REAC:R-HSA-6803529 | FGFR2 alternative splicing | FGFR2 alternative splicing | 3 | 3.949662e-02 | 5 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0461461 | Skin 1; langerhans cells[≥Low] | Skin 1; langerhans cells[≥Low] | 19 | 5.031606e-10 | 5 |
| HPA | HPA:0471462 | Skin 2; langerhans cells[≥Medium] | Skin 2; langerhans cells[≥Medium] | 18 | 1.590168e-09 | 5 |
| HPA | HPA:0471461 | Skin 2; langerhans cells[≥Low] | Skin 2; langerhans cells[≥Low] | 19 | 2.795807e-09 | 5 |
| HPA | HPA:0470201 | Skin 2; endothelial cells[≥Low] | Skin 2; endothelial cells[≥Low] | 19 | 2.197720e-08 | 5 |
| HPA | HPA:0461462 | Skin 1; langerhans cells[≥Medium] | Skin 1; langerhans cells[≥Medium] | 16 | 2.627055e-08 | 5 |
| HPA | HPA:0471441 | Skin 2; fibrohistiocytic cells[≥Low] | Skin 2; fibrohistiocytic cells[≥Low] | 20 | 2.751623e-08 | 5 |
| HPA | HPA:0471412 | Skin 2; cells in spinous layer[≥Medium] | Skin 2; cells in spinous layer[≥Medium] | 17 | 3.018999e-08 | 5 |
| HPA | HPA:0471411 | Skin 2; cells in spinous layer[≥Low] | Skin 2; cells in spinous layer[≥Low] | 18 | 1.491154e-07 | 5 |
| HPA | HPA:0461411 | Skin 1; cells in spinous layer[≥Low] | Skin 1; cells in spinous layer[≥Low] | 17 | 1.593461e-07 | 5 |
| HPA | HPA:0461412 | Skin 1; cells in spinous layer[≥Medium] | Skin 1; cells in spinous layer[≥Medium] | 15 | 4.042588e-07 | 5 |
| HPA | HPA:0460181 | Skin 1; cells in granular layer[≥Low] | Skin 1; cells in granular layer[≥Low] | 16 | 5.527607e-07 | 5 |
| HPA | HPA:0471391 | Skin 2; cells in basal layer[≥Low] | Skin 2; cells in basal layer[≥Low] | 18 | 7.417510e-07 | 5 |
| HPA | HPA:0460201 | Skin 1; endothelial cells[≥Low] | Skin 1; endothelial cells[≥Low] | 17 | 7.548932e-07 | 5 |
| HPA | HPA:0470202 | Skin 2; endothelial cells[≥Medium] | Skin 2; endothelial cells[≥Medium] | 15 | 1.104109e-06 | 5 |
| HPA | HPA:0461392 | Skin 1; cells in basal layer[≥Medium] | Skin 1; cells in basal layer[≥Medium] | 15 | 1.128001e-06 | 5 |
| HPA | HPA:0461463 | Skin 1; langerhans cells[High] | Skin 1; langerhans cells[High] | 10 | 1.351052e-06 | 5 |
| HPA | HPA:0461441 | Skin 1; fibrohistiocytic cells[≥Low] | Skin 1; fibrohistiocytic cells[≥Low] | 17 | 1.637971e-06 | 5 |
| HPA | HPA:0470182 | Skin 2; cells in granular layer[≥Medium] | Skin 2; cells in granular layer[≥Medium] | 14 | 2.075537e-06 | 5 |
| HPA | HPA:0461491 | Skin 1; vascular mural cells[≥Low] | Skin 1; vascular mural cells[≥Low] | 10 | 3.676178e-06 | 5 |
| HPA | HPA:0460202 | Skin 1; endothelial cells[≥Medium] | Skin 1; endothelial cells[≥Medium] | 14 | 4.023143e-06 | 5 |
| HPA | HPA:0471442 | Skin 2; fibrohistiocytic cells[≥Medium] | Skin 2; fibrohistiocytic cells[≥Medium] | 16 | 5.367381e-06 | 5 |
| HPA | HPA:0301361 | Lung; alveolar cells type I[≥Low] | Lung; alveolar cells type I[≥Low] | 18 | 5.456265e-06 | 5 |
| HPA | HPA:0461492 | Skin 1; vascular mural cells[≥Medium] | Skin 1; vascular mural cells[≥Medium] | 9 | 6.194002e-06 | 5 |
| HPA | HPA:0461393 | Skin 1; cells in basal layer[High] | Skin 1; cells in basal layer[High] | 9 | 6.786313e-06 | 5 |
| HPA | HPA:0471492 | Skin 2; vascular mural cells[≥Medium] | Skin 2; vascular mural cells[≥Medium] | 9 | 7.100626e-06 | 5 |
| HPA | HPA:0461493 | Skin 1; vascular mural cells[High] | Skin 1; vascular mural cells[High] | 8 | 7.288098e-06 | 5 |
| HPA | HPA:0470672 | Skin 2; melanocytes[≥Medium] | Skin 2; melanocytes[≥Medium] | 14 | 1.054826e-05 | 5 |
| HPA | HPA:0471392 | Skin 2; cells in basal layer[≥Medium] | Skin 2; cells in basal layer[≥Medium] | 15 | 1.092565e-05 | 5 |
| HPA | HPA:0461391 | Skin 1; cells in basal layer[≥Low] | Skin 1; cells in basal layer[≥Low] | 16 | 1.183710e-05 | 5 |
| HPA | HPA:0301362 | Lung; alveolar cells type I[≥Medium] | Lung; alveolar cells type I[≥Medium] | 16 | 1.302084e-05 | 5 |
| HPA | HPA:0460182 | Skin 1; cells in granular layer[≥Medium] | Skin 1; cells in granular layer[≥Medium] | 13 | 1.730830e-05 | 5 |
| HPA | HPA:0471471 | Skin 2; lymphocytes[≥Low] | Skin 2; lymphocytes[≥Low] | 15 | 2.432131e-05 | 5 |
| HPA | HPA:0461442 | Skin 1; fibrohistiocytic cells[≥Medium] | Skin 1; fibrohistiocytic cells[≥Medium] | 14 | 3.171937e-05 | 5 |
| HPA | HPA:0460203 | Skin 1; endothelial cells[High] | Skin 1; endothelial cells[High] | 10 | 4.538002e-05 | 5 |
| HPA | HPA:0470181 | Skin 2; cells in granular layer[≥Low] | Skin 2; cells in granular layer[≥Low] | 14 | 4.574436e-05 | 5 |
| HPA | HPA:0471491 | Skin 2; vascular mural cells[≥Low] | Skin 2; vascular mural cells[≥Low] | 9 | 4.821180e-05 | 5 |
| HPA | HPA:0470671 | Skin 2; melanocytes[≥Low] | Skin 2; melanocytes[≥Low] | 14 | 4.897935e-05 | 5 |
| HPA | HPA:0301363 | Lung; alveolar cells type I[High] | Lung; alveolar cells type I[High] | 12 | 5.179535e-05 | 5 |
| HPA | HPA:0471472 | Skin 2; lymphocytes[≥Medium] | Skin 2; lymphocytes[≥Medium] | 13 | 9.652806e-05 | 5 |
| HPA | HPA:0301371 | Lung; alveolar cells type II[≥Low] | Lung; alveolar cells type II[≥Low] | 19 | 1.878611e-04 | 5 |
| HPA | HPA:0461413 | Skin 1; cells in spinous layer[High] | Skin 1; cells in spinous layer[High] | 8 | 1.964517e-04 | 5 |
| HPA | HPA:0300203 | Lung; endothelial cells[High] | Lung; endothelial cells[High] | 9 | 2.581834e-04 | 5 |
| HPA | HPA:0160251 | Endometrium 1; cells in endometrial stroma[≥Low] | Endometrium 1; cells in endometrial stroma[≥Low] | 31 | 2.851773e-04 | 5 |
| HPA | HPA:0461471 | Skin 1; lymphocytes[≥Low] | Skin 1; lymphocytes[≥Low] | 13 | 2.917207e-04 | 5 |
| HPA | HPA:0630223 | Cervix; squamous epithelial cells[High] | Cervix; squamous epithelial cells[High] | 15 | 6.562770e-04 | 5 |
| HPA | HPA:0310431 | Lymph node; germinal center cells[≥Low] | Lymph node; germinal center cells[≥Low] | 34 | 6.895041e-04 | 5 |
| HPA | HPA:0300202 | Lung; endothelial cells[≥Medium] | Lung; endothelial cells[≥Medium] | 12 | 7.498481e-04 | 5 |
| HPA | HPA:0460183 | Skin 1; cells in granular layer[High] | Skin 1; cells in granular layer[High] | 8 | 7.612094e-04 | 5 |
| HPA | HPA:0380202 | Placenta; endothelial cells[≥Medium] | Placenta; endothelial cells[≥Medium] | 9 | 7.612373e-04 | 5 |
| HPA | HPA:0310432 | Lymph node; germinal center cells[≥Medium] | Lymph node; germinal center cells[≥Medium] | 27 | 9.181576e-04 | 5 |
| HPA | HPA:0630052 | Cervix; glandular cells[≥Medium] | Cervix; glandular cells[≥Medium] | 30 | 1.010552e-03 | 5 |
| HPA | HPA:0300201 | Lung; endothelial cells[≥Low] | Lung; endothelial cells[≥Low] | 13 | 1.040479e-03 | 5 |
| HPA | HPA:0301372 | Lung; alveolar cells type II[≥Medium] | Lung; alveolar cells type II[≥Medium] | 16 | 1.154541e-03 | 5 |
| HPA | HPA:0471463 | Skin 2; langerhans cells[High] | Skin 2; langerhans cells[High] | 8 | 1.278067e-03 | 5 |
| HPA | HPA:0170253 | Endometrium 2; cells in endometrial stroma[High] | Endometrium 2; cells in endometrial stroma[High] | 9 | 1.340342e-03 | 5 |
| HPA | HPA:0461472 | Skin 1; lymphocytes[≥Medium] | Skin 1; lymphocytes[≥Medium] | 11 | 1.452747e-03 | 5 |
| HPA | HPA:0471493 | Skin 2; vascular mural cells[High] | Skin 2; vascular mural cells[High] | 6 | 1.801873e-03 | 5 |
| HPA | HPA:0170251 | Endometrium 2; cells in endometrial stroma[≥Low] | Endometrium 2; cells in endometrial stroma[≥Low] | 27 | 3.433796e-03 | 5 |
| HPA | HPA:0570811 | Testis; spermatogonia cells[≥Low] | Testis; spermatogonia cells[≥Low] | 25 | 3.462677e-03 | 5 |
| HPA | HPA:0160252 | Endometrium 1; cells in endometrial stroma[≥Medium] | Endometrium 1; cells in endometrial stroma[≥Medium] | 21 | 3.481994e-03 | 5 |
| HPA | HPA:0380201 | Placenta; endothelial cells[≥Low] | Placenta; endothelial cells[≥Low] | 9 | 3.615414e-03 | 5 |
| HPA | HPA:0050053 | Breast; glandular cells[High] | Breast; glandular cells[High] | 16 | 3.719629e-03 | 5 |
| HPA | HPA:0461443 | Skin 1; fibrohistiocytic cells[High] | Skin 1; fibrohistiocytic cells[High] | 9 | 3.760141e-03 | 5 |
| HPA | HPA:0590053 | Thyroid gland; glandular cells[High] | Thyroid gland; glandular cells[High] | 19 | 4.162908e-03 | 5 |
| HPA | HPA:0470203 | Skin 2; endothelial cells[High] | Skin 2; endothelial cells[High] | 8 | 4.910544e-03 | 5 |
| HPA | HPA:0301373 | Lung; alveolar cells type II[High] | Lung; alveolar cells type II[High] | 11 | 5.575363e-03 | 5 |
| HPA | HPA:0600432 | Tonsil; germinal center cells[≥Medium] | Tonsil; germinal center cells[≥Medium] | 29 | 5.942322e-03 | 5 |
| HPA | HPA:0570763 | Testis; pachytene spermatocytes[High] | Testis; pachytene spermatocytes[High] | 13 | 6.780094e-03 | 5 |
| HPA | HPA:0380203 | Placenta; endothelial cells[High] | Placenta; endothelial cells[High] | 7 | 7.073427e-03 | 5 |
| HPA | HPA:0570812 | Testis; spermatogonia cells[≥Medium] | Testis; spermatogonia cells[≥Medium] | 22 | 8.689659e-03 | 5 |
| HPA | HPA:0471473 | Skin 2; lymphocytes[High] | Skin 2; lymphocytes[High] | 9 | 9.065133e-03 | 5 |
| HPA | HPA:0010013 | Adipose tissue; adipocytes[High] | Adipose tissue; adipocytes[High] | 9 | 9.706787e-03 | 5 |
| HPA | HPA:0460673 | Skin 1; melanocytes[High] | Skin 1; melanocytes[High] | 13 | 1.003849e-02 | 5 |
| HPA | HPA:0130203 | Colon; endothelial cells[High] | Colon; endothelial cells[High] | 12 | 1.164105e-02 | 5 |
| HPA | HPA:0500651 | Soft tissue 1; fibroblasts[≥Low] | Soft tissue 1; fibroblasts[≥Low] | 29 | 1.188096e-02 | 5 |
| HPA | HPA:0050012 | Breast; adipocytes[≥Medium] | Breast; adipocytes[≥Medium] | 16 | 1.271805e-02 | 5 |
| HPA | HPA:0130653 | Colon; fibroblasts[High] | Colon; fibroblasts[High] | 4 | 1.312533e-02 | 5 |
| HPA | HPA:0610833 | Urinary bladder; urothelial cells[High] | Urinary bladder; urothelial cells[High] | 19 | 1.320068e-02 | 5 |
| HPA | HPA:0570793 | Testis; round or early spermatids[High] | Testis; round or early spermatids[High] | 13 | 1.599134e-02 | 5 |
| HPA | HPA:0340462 | Ovary; ovarian stroma cells[≥Medium] | Ovary; ovarian stroma cells[≥Medium] | 19 | 1.613959e-02 | 5 |
| HPA | HPA:0050052 | Breast; glandular cells[≥Medium] | Breast; glandular cells[≥Medium] | 32 | 1.639734e-02 | 5 |
| HPA | HPA:0100123 | Cerebral cortex; glial cells[High] | Cerebral cortex; glial cells[High] | 11 | 1.648300e-02 | 5 |
| HPA | HPA:0570792 | Testis; round or early spermatids[≥Medium] | Testis; round or early spermatids[≥Medium] | 18 | 2.079284e-02 | 5 |
| HPA | HPA:0461473 | Skin 1; lymphocytes[High] | Skin 1; lymphocytes[High] | 8 | 2.144165e-02 | 5 |
| HPA | HPA:0510703 | Soft tissue 2; peripheral nerve[High] | Soft tissue 2; peripheral nerve[High] | 7 | 2.251281e-02 | 5 |
| HPA | HPA:0500652 | Soft tissue 1; fibroblasts[≥Medium] | Soft tissue 1; fibroblasts[≥Medium] | 22 | 2.259640e-02 | 5 |
| HPA | HPA:0090193 | Cerebellum; cells in molecular layer[High] | Cerebellum; cells in molecular layer[High] | 12 | 2.347060e-02 | 5 |
| HPA | HPA:0570801 | Testis; sertoli cells[≥Low] | Testis; sertoli cells[≥Low] | 21 | 2.566341e-02 | 5 |
| HPA | HPA:0351183 | Pancreas; pancreatic endocrine cells[High] | Pancreas; pancreatic endocrine cells[High] | 11 | 3.193312e-02 | 5 |
| HPA | HPA:0090192 | Cerebellum; cells in molecular layer[≥Medium] | Cerebellum; cells in molecular layer[≥Medium] | 22 | 3.286449e-02 | 5 |
| HPA | HPA:0010011 | Adipose tissue; adipocytes[≥Low] | Adipose tissue; adipocytes[≥Low] | 27 | 3.307820e-02 | 5 |
| HPA | HPA:0010000 | Adipose tissue | Adipose tissue | 27 | 3.307820e-02 | 5 |
| HPA | HPA:0050051 | Breast; glandular cells[≥Low] | Breast; glandular cells[≥Low] | 37 | 3.332401e-02 | 5 |
| HPA | HPA:0250123 | Hippocampus; glial cells[High] | Hippocampus; glial cells[High] | 9 | 4.052877e-02 | 5 |
| HPA | HPA:0340461 | Ovary; ovarian stroma cells[≥Low] | Ovary; ovarian stroma cells[≥Low] | 27 | 4.136450e-02 | 5 |
| HPA | HPA:0570813 | Testis; spermatogonia cells[High] | Testis; spermatogonia cells[High] | 15 | 4.259429e-02 | 5 |
| HPA | HPA:0381201 | Placenta; hofbauer cells[≥Low] | Placenta; hofbauer cells[≥Low] | 8 | 4.315803e-02 | 5 |
| HPA | HPA:0430053 | Seminal vesicle; glandular cells[High] | Seminal vesicle; glandular cells[High] | 15 | 4.392138e-02 | 5 |
| HPA | HPA:0190223 | Esophagus; squamous epithelial cells[High] | Esophagus; squamous epithelial cells[High] | 16 | 4.475921e-02 | 5 |
| HPA | HPA:0050093 | Breast; myoepithelial cells[High] | Breast; myoepithelial cells[High] | 11 | 4.608565e-02 | 5 |
| HPA | HPA:0010012 | Adipose tissue; adipocytes[≥Medium] | Adipose tissue; adipocytes[≥Medium] | 19 | 4.828150e-02 | 5 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 32 | 5.064717e-10 | 5 |
| GO:CC | GO:0005681 | spliceosomal complex | "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] | 10 | 6.587949e-09 | 5 |
| GO:CC | GO:0005829 | cytosol | "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] | 33 | 1.175131e-07 | 5 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 33 | 1.211331e-07 | 5 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 36 | 1.258948e-07 | 5 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 36 | 1.258948e-07 | 5 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 36 | 1.258948e-07 | 5 |
| GO:CC | GO:0071013 | catalytic step 2 spliceosome | "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] | 6 | 1.153501e-05 | 5 |
| GO:CC | GO:0010494 | cytoplasmic stress granule | "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] | 5 | 4.507561e-04 | 5 |
| GO:CC | GO:0034709 | methylosome | "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452] | 3 | 6.693990e-04 | 5 |
| GO:CC | GO:0043229 | intracellular organelle | "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] | 48 | 8.297691e-04 | 5 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 38 | 1.098495e-03 | 5 |
| GO:CC | GO:0043231 | intracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 46 | 1.272219e-03 | 5 |
| GO:CC | GO:0070062 | extracellular exosome | "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] | 16 | 1.611976e-03 | 5 |
| GO:CC | GO:1903561 | extracellular vesicle | "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] | 16 | 1.931720e-03 | 5 |
| GO:CC | GO:0043230 | extracellular organelle | "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] | 16 | 1.943299e-03 | 5 |
| GO:CC | GO:0065010 | extracellular membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] | 16 | 1.943299e-03 | 5 |
| GO:CC | GO:0043227 | membrane-bounded organelle | "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] | 47 | 2.975787e-03 | 5 |
| GO:CC | GO:0005689 | U12-type spliceosomal complex | "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955] | 3 | 6.698481e-03 | 5 |
| GO:CC | GO:0043226 | organelle | "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] | 48 | 7.216644e-03 | 5 |
| GO:CC | GO:0005622 | intracellular anatomical structure | "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] | 49 | 7.635466e-03 | 5 |
| GO:CC | GO:0016607 | nuclear speck | "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [PMID:28977640] | 7 | 8.339282e-03 | 5 |
| GO:CC | GO:1990904 | ribonucleoprotein complex | "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] | 17 | 9.948669e-03 | 5 |
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 41 | 1.227338e-02 | 5 |
| GO:CC | GO:0031982 | vesicle | "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] | 21 | 1.295564e-02 | 5 |
| GO:CC | GO:0034715 | pICln-Sm protein complex | "A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG." [GOC:mah, PMID:11713266] | 2 | 1.670849e-02 | 5 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 13 | 2.181318e-02 | 5 |
| GO:CC | GO:0005615 | extracellular space | "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] | 18 | 3.423339e-02 | 5 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03040 | Spliceosome | Spliceosome | 10 | 9.695026e-09 | 5 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-615-3p | hsa-mir-615-3p | hsa-mir-615-3p | 16 | 0.000002 | 5 |
| MIRNA | MIRNA:hsa-mir-218-5p | hsa-mir-218-5p | hsa-mir-218-5p | 14 | 0.000020 | 5 |
| MIRNA | MIRNA:hsa-mir-3179 | hsa-mir-3179 | hsa-mir-3179 | 15 | 0.001812 | 5 |
| MIRNA | MIRNA:hsa-mir-548ac | hsa-mir-548ac | hsa-mir-548ac | 17 | 0.006709 | 5 |
| MIRNA | MIRNA:hsa-mir-548z | hsa-mir-548z | hsa-mir-548z | 17 | 0.006709 | 5 |
| MIRNA | MIRNA:hsa-mir-548d-3p | hsa-mir-548d-3p | hsa-mir-548d-3p | 17 | 0.006954 | 5 |
| MIRNA | MIRNA:hsa-mir-4289 | hsa-mir-4289 | hsa-mir-4289 | 11 | 0.007012 | 5 |
| MIRNA | MIRNA:hsa-mir-1-3p | hsa-mir-1-3p | hsa-mir-1-3p | 11 | 0.019960 | 5 |
| MIRNA | MIRNA:hsa-mir-4802-3p | hsa-mir-4802-3p | hsa-mir-4802-3p | 12 | 0.028221 | 5 |
| MIRNA | MIRNA:hsa-mir-92a-3p | hsa-mir-92a-3p | hsa-mir-92a-3p | 13 | 0.035244 | 5 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M00738 | Factor: E2F-4:DP-1; motif: TTTSGCGC | Factor: E2F-4:DP-1; motif: TTTSGCGC | 43 | 0.000085 | 5 |
| TF | TF:M00940 | Factor: E2F-1; motif: NTTTCGCGCS | Factor: E2F-1; motif: NTTTCGCGCS | 36 | 0.004946 | 5 |
| TF | TF:M00050 | Factor: E2F; motif: TTTSGCGC | Factor: E2F; motif: TTTSGCGC | 34 | 0.005200 | 5 |
| TF | TF:M12554_1 | Factor: YY2; motif: NNATGGCGGCN; match class: 1 | Factor: YY2; motif: NNATGGCGGCN; match class: 1 | 7 | 0.006341 | 5 |
| TF | TF:M00737_1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 | 21 | 0.006480 | 5 |
| TF | TF:M00737 | Factor: E2F-1:DP-2; motif: TTTSSCGC | Factor: E2F-1:DP-2; motif: TTTSSCGC | 38 | 0.006541 | 5 |
| TF | TF:M09641 | Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN | Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN | 22 | 0.007322 | 5 |
| TF | TF:M08020 | Factor: YY2; motif: NNCCGCCATTW | Factor: YY2; motif: NNCCGCCATTW | 15 | 0.008874 | 5 |
| TF | TF:M00695 | Factor: ETF; motif: GVGGMGG | Factor: ETF; motif: GVGGMGG | 41 | 0.021328 | 5 |
| TF | TF:M00736_1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 | 26 | 0.022274 | 5 |
| TF | TF:M12554 | Factor: YY2; motif: NNATGGCGGCN | Factor: YY2; motif: NNATGGCGGCN | 19 | 0.022457 | 5 |
| TF | TF:M01240_1 | Factor: BEN; motif: CAGCGRNV; match class: 1 | Factor: BEN; motif: CAGCGRNV; match class: 1 | 46 | 0.026846 | 5 |
| TF | TF:M12722 | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS | Factor: ZXDL; motif: GSGSCNNGGGMRGCNCCGGGS | 41 | 0.032487 | 5 |
| TF | TF:M08874 | Factor: E2F1; motif: NNNNNGCGSSAAAN | Factor: E2F1; motif: NNNNNGCGSSAAAN | 33 | 0.035359 | 5 |
| TF | TF:M02044 | Factor: YY1; motif: GCCGCCATTTTG | Factor: YY1; motif: GCCGCCATTTTG | 30 | 0.038366 | 5 |
| TF | TF:M03925_1 | Factor: YY2; motif: NCCGCCATNTY; match class: 1 | Factor: YY2; motif: NCCGCCATNTY; match class: 1 | 10 | 0.042368 | 5 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2755 | 17S U2 snRNP | 17S U2 snRNP | 5 | 0.000504 | 5 |
| CORUM | CORUM:351 | Spliceosome | Spliceosome | 8 | 0.000914 | 5 |
| CORUM | CORUM:1332 | Large Drosha complex | Large Drosha complex | 4 | 0.003020 | 5 |
| CORUM | CORUM:1181 | C complex spliceosome | C complex spliceosome | 6 | 0.003828 | 5 |
| CORUM | CORUM:1745 | SMN complex | SMN complex | 3 | 0.037432 | 5 |
| CORUM | CORUM:1148 | snRNP-free U1A (SF-A) complex | snRNP-free U1A (SF-A) complex | 2 | 0.049693 | 5 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0002795 | Abnormal respiratory system physiology | Abnormal function of the respiratory system. | 14 | 0.012355 | 5 |
| HP | HP:0002763 | Abnormal cartilage morphology | Any morphological abnormality of cartilage. | 4 | 0.021908 | 5 |
WashU (Leiden)
Community 0
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP179 | Cell cycle | Cell cycle | 10 | 2.303371e-16 | 0 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 6 | 5.456684e-08 | 0 |
| WP | WP:WP53 | ID signaling | ID signaling | 3 | 1.081700e-04 | 0 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 4 | 1.089521e-04 | 0 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 4 | 5.351187e-04 | 0 |
| WP | WP:WP5121 | Sphingolipid metabolism in senescence | Sphingolipid metabolism in senescence | 3 | 6.276020e-04 | 0 |
| WP | WP:WP3391 | Senescence associated secretory phenotype SASP | Senescence associated secretory phenotype SASP | 4 | 1.032591e-03 | 0 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 6 | 1.703005e-03 | 0 |
| WP | WP:WP236 | Adipogenesis | Adipogenesis | 4 | 1.866676e-03 | 0 |
| WP | WP:WP1971 | Integrated cancer pathway | Integrated cancer pathway | 3 | 2.509490e-03 | 0 |
| WP | WP:WP2586 | Aryl hydrocarbon receptor pathway | Aryl hydrocarbon receptor pathway | 3 | 2.872375e-03 | 0 |
| WP | WP:WP4685 | Melanoma | Melanoma | 3 | 9.340609e-03 | 0 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 3 | 9.758465e-03 | 0 |
| WP | WP:WP4255 | Non small cell lung cancer | Non small cell lung cancer | 3 | 1.108514e-02 | 0 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 3 | 1.155226e-02 | 0 |
| WP | WP:WP2261 | Glioblastoma signaling | Glioblastoma signaling | 3 | 1.634752e-02 | 0 |
| WP | WP:WP4263 | Pancreatic adenocarcinoma pathway | Pancreatic adenocarcinoma pathway | 3 | 2.017293e-02 | 0 |
| WP | WP:WP2263 | Androgen receptor network in prostate cancer | Androgen receptor network in prostate cancer | 3 | 4.230649e-02 | 0 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 10 | 2.239892e-15 | 0 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 8 | 9.556266e-11 | 0 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 7 | 6.733953e-08 | 0 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 5 | 3.453337e-06 | 0 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 6 | 3.677561e-06 | 0 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 6 | 6.529881e-06 | 0 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 5 | 5.884267e-05 | 0 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 6 | 7.591329e-05 | 0 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 4 | 2.917810e-04 | 0 |
| KEGG | KEGG:04068 | FoxO signaling pathway | FoxO signaling pathway | 4 | 9.645993e-04 | 0 |
| KEGG | KEGG:05219 | Bladder cancer | Bladder cancer | 3 | 9.852954e-04 | 0 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 6 | 1.154868e-03 | 0 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 4 | 1.562099e-03 | 0 |
| KEGG | KEGG:04934 | Cushing syndrome | Cushing syndrome | 4 | 1.780585e-03 | 0 |
| KEGG | KEGG:05160 | Hepatitis C | Hepatitis C | 4 | 2.020797e-03 | 0 |
| KEGG | KEGG:05218 | Melanoma | Melanoma | 3 | 5.392562e-03 | 0 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | Non-small cell lung cancer | 3 | 5.392562e-03 | 0 |
| KEGG | KEGG:05214 | Glioma | Glioma | 3 | 6.092521e-03 | 0 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 3 | 6.338396e-03 | 0 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 3 | 6.338396e-03 | 0 |
| KEGG | KEGG:01522 | Endocrine resistance | Endocrine resistance | 3 | 1.231247e-02 | 0 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | Progesterone-mediated oocyte maturation | 3 | 1.519747e-02 | 0 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | Ubiquitin mediated proteolysis | 3 | 3.855923e-02 | 0 |
| KEGG | KEGG:05224 | Breast cancer | Breast cancer | 3 | 4.446099e-02 | 0 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 11 | 1.285962e-13 | 0 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 10 | 1.486536e-13 | 0 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 11 | 9.437401e-13 | 0 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 10 | 1.330170e-12 | 0 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 8 | 1.270687e-11 | 0 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 8 | 3.639130e-11 | 0 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 11 | 5.108817e-11 | 0 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 11 | 9.186373e-10 | 0 |
| GO:BP | GO:1901988 | negative regulation of cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 7 | 1.156403e-08 | 0 |
| GO:BP | GO:0010948 | negative regulation of cell cycle process | "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 7 | 3.392654e-08 | 0 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 7 | 8.072860e-08 | 0 |
| GO:BP | GO:1901991 | negative regulation of mitotic cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 6 | 1.532717e-07 | 0 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 7 | 2.186059e-07 | 0 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 7 | 5.217443e-07 | 0 |
| GO:BP | GO:0045930 | negative regulation of mitotic cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 6 | 7.758040e-07 | 0 |
| GO:BP | GO:1905784 | regulation of anaphase-promoting complex-dependent catabolic process | "Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876] | 3 | 1.330728e-06 | 0 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 7 | 1.400491e-06 | 0 |
| GO:BP | GO:0000086 | G2/M transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] | 5 | 6.570330e-06 | 0 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 8 | 8.927375e-06 | 0 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 5 | 9.642012e-06 | 0 |
| GO:BP | GO:0044839 | cell cycle G2/M phase transition | "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle] | 5 | 1.174484e-05 | 0 |
| GO:BP | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 4 | 1.835357e-05 | 0 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 7 | 1.962801e-05 | 0 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 5 | 2.152446e-05 | 0 |
| GO:BP | GO:1902807 | negative regulation of cell cycle G1/S phase transition | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 4 | 2.604245e-05 | 0 |
| GO:BP | GO:0000075 | cell cycle checkpoint signaling | "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] | 5 | 2.763840e-05 | 0 |
| GO:BP | GO:0090398 | cellular senescence | "A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest." [GOC:BHF, PMID:28682291] | 4 | 2.015882e-04 | 0 |
| GO:BP | GO:0031145 | anaphase-promoting complex-dependent catabolic process | "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442] | 3 | 3.043247e-04 | 0 |
| GO:BP | GO:0000077 | DNA damage checkpoint signaling | "A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah] | 4 | 3.283206e-04 | 0 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 11 | 3.897310e-04 | 0 |
| GO:BP | GO:0031570 | DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] | 4 | 4.456158e-04 | 0 |
| GO:BP | GO:0007093 | mitotic cell cycle checkpoint signaling | "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] | 4 | 6.668814e-04 | 0 |
| GO:BP | GO:1905786 | positive regulation of anaphase-promoting complex-dependent catabolic process | "Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876] | 2 | 9.328404e-04 | 0 |
| GO:BP | GO:0042770 | signal transduction in response to DNA damage | "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators] | 4 | 1.745579e-03 | 0 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 9 | 2.815304e-03 | 0 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 11 | 3.021380e-03 | 0 |
| GO:BP | GO:0070345 | negative regulation of fat cell proliferation | "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] | 2 | 3.107693e-03 | 0 |
| GO:BP | GO:0043550 | regulation of lipid kinase activity | "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf] | 2 | 3.107693e-03 | 0 |
| GO:BP | GO:0048146 | positive regulation of fibroblast proliferation | "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] | 3 | 3.254870e-03 | 0 |
| GO:BP | GO:0051338 | regulation of transferase activity | "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] | 5 | 3.749840e-03 | 0 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] | 6 | 4.076640e-03 | 0 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 9 | 6.131470e-03 | 0 |
| GO:BP | GO:0044773 | mitotic DNA damage checkpoint signaling | "A signal transduction process involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 7.150412e-03 | 0 |
| GO:BP | GO:0019222 | regulation of metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] | 11 | 7.315282e-03 | 0 |
| GO:BP | GO:0044774 | mitotic DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle] | 3 | 8.457959e-03 | 0 |
| GO:BP | GO:0033554 | cellular response to stress | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] | 7 | 1.126930e-02 | 0 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] | 4 | 1.373280e-02 | 0 |
| GO:BP | GO:1904668 | positive regulation of ubiquitin protein ligase activity | "Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882] | 2 | 1.396468e-02 | 0 |
| GO:BP | GO:0070344 | regulation of fat cell proliferation | "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] | 2 | 1.396468e-02 | 0 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 9 | 1.499272e-02 | 0 |
| GO:BP | GO:0048145 | regulation of fibroblast proliferation | "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] | 3 | 1.525834e-02 | 0 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] | 7 | 2.293857e-02 | 0 |
| GO:BP | GO:0010389 | regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565] | 3 | 2.424316e-02 | 0 |
| GO:BP | GO:0031398 | positive regulation of protein ubiquitination | "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] | 3 | 2.637971e-02 | 0 |
| GO:BP | GO:0048144 | fibroblast proliferation | "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] | 3 | 2.711855e-02 | 0 |
| GO:BP | GO:0070341 | fat cell proliferation | "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl] | 2 | 3.253777e-02 | 0 |
| GO:BP | GO:1902749 | regulation of cell cycle G2/M phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 3 | 3.439064e-02 | 0 |
| GO:BP | GO:0006275 | regulation of DNA replication | "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] | 3 | 3.616398e-02 | 0 |
| GO:BP | GO:0071732 | cellular response to nitric oxide | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf] | 2 | 3.717542e-02 | 0 |
| GO:BP | GO:0007265 | Ras protein signal transduction | "An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf] | 3 | 3.893530e-02 | 0 |
| GO:BP | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] | 3 | 4.593741e-02 | 0 |
| GO:BP | GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] | 3 | 4.700062e-02 | 0 |
| GO:BP | GO:1902170 | cellular response to reactive nitrogen species | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus." [GOC:sl, GOC:TermGenie, PMID:22504638] | 2 | 4.737161e-02 | 0 |
| GO:BP | GO:1901875 | positive regulation of post-translational protein modification | "Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] | 3 | 4.807990e-02 | 0 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 9 | 1.847777e-13 | 0 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 11 | 1.320530e-12 | 0 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 7 | 1.614729e-12 | 0 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 7 | 1.614729e-12 | 0 |
| REAC | REAC:R-HSA-1538133 | G0 and Early G1 | G0 and Early G1 | 6 | 1.306663e-11 | 0 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 11 | 1.394593e-11 | 0 |
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 6 | 1.101155e-10 | 0 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 7 | 1.149231e-10 | 0 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 6 | 1.559491e-10 | 0 |
| REAC | REAC:R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 5 | 3.134522e-10 | 0 |
| REAC | REAC:R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | TP53 Regulates Transcription of Cell Cycle Genes | 6 | 7.865483e-10 | 0 |
| REAC | REAC:R-HSA-68911 | G2 Phase | G2 Phase | 4 | 8.234452e-10 | 0 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 7 | 2.789272e-09 | 0 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 7 | 1.260667e-08 | 0 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 6 | 1.944281e-08 | 0 |
| REAC | REAC:R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 4 | 1.640997e-07 | 0 |
| REAC | REAC:R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 4 | 3.895712e-07 | 0 |
| REAC | REAC:R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 4 | 3.895712e-07 | 0 |
| REAC | REAC:R-HSA-2559583 | Cellular Senescence | Cellular Senescence | 6 | 3.638555e-06 | 0 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 5 | 3.955258e-06 | 0 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 5 | 3.955258e-06 | 0 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 6 | 4.112583e-06 | 0 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 9 | 3.709918e-05 | 0 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 4 | 7.808680e-05 | 0 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 9 | 8.443365e-05 | 0 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 6 | 1.418631e-04 | 0 |
| REAC | REAC:R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | Transcription of E2F targets under negative control by DREAM complex | 3 | 1.833848e-04 | 0 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 9 | 2.283749e-04 | 0 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 4 | 2.635769e-04 | 0 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 4 | 4.401785e-04 | 0 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 3 | 6.541317e-04 | 0 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 7 | 7.853436e-04 | 0 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 7 | 8.834936e-04 | 0 |
| REAC | REAC:R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | Senescence-Associated Secretory Phenotype (SASP) | 4 | 9.343484e-04 | 0 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 4 | 1.318601e-03 | 0 |
| REAC | REAC:R-HSA-176417 | Phosphorylation of Emi1 | Phosphorylation of Emi1 | 2 | 4.145728e-03 | 0 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 4 | 7.401961e-03 | 0 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 4 | 8.905160e-03 | 0 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 3 | 1.001776e-02 | 0 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 3 | 1.001776e-02 | 0 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 3 | 1.095938e-02 | 0 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 3 | 1.247818e-02 | 0 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 3 | 1.356390e-02 | 0 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 3 | 1.412929e-02 | 0 |
| REAC | REAC:R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | DNA Damage/Telomere Stress Induced Senescence | 3 | 1.718929e-02 | 0 |
| REAC | REAC:R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2 | 2.147562e-02 | 0 |
| REAC | REAC:R-HSA-9616222 | Transcriptional regulation of granulopoiesis | Transcriptional regulation of granulopoiesis | 3 | 2.293936e-02 | 0 |
| REAC | REAC:R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | FOXO-mediated transcription of cell cycle genes | 2 | 3.736306e-02 | 0 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 4 | 4.052244e-02 | 0 |
| REAC | REAC:R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2 | 4.201052e-02 | 0 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5144 | E2F1-p107-cyclinA complex | E2F1-p107-cyclinA complex | 3 | 6.239924e-07 | 0 |
| CORUM | CORUM:1661 | E2F4-p107-cyclinA complex | E2F4-p107-cyclinA complex | 2 | 1.264583e-03 | 0 |
| CORUM | CORUM:6444 | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex | 2 | 6.304228e-03 | 0 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 11 | 0.000001 | 0 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 11 | 0.000026 | 0 |
| GO:CC | GO:0097124 | cyclin A2-CDK2 complex | "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 2 | 0.000072 | 0 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 6 | 0.000197 | 0 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 11 | 0.000206 | 0 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 11 | 0.000206 | 0 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 11 | 0.000206 | 0 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 5 | 0.000318 | 0 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 3 | 0.000482 | 0 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 11 | 0.001375 | 0 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 3 | 0.004136 | 0 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 3 | 0.005506 | 0 |
| GO:CC | GO:0005680 | anaphase-promoting complex | "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] | 2 | 0.006066 | 0 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 6 | 0.009286 | 0 |
| GO:CC | GO:0031461 | cullin-RING ubiquitin ligase complex | "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] | 3 | 0.010479 | 0 |
| GO:CC | GO:0005694 | chromosome | "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] | 6 | 0.017975 | 0 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 11 | 0.018554 | 0 |
| GO:CC | GO:0000152 | nuclear ubiquitin ligase complex | "A ubiquitin ligase complex found in the nucleus." [GOC:mah] | 2 | 0.027996 | 0 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 4 | 0.037486 | 0 |
| GO:CC | GO:0000151 | ubiquitin ligase complex | "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] | 3 | 0.049980 | 0 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:1990756 | ubiquitin-like ligase-substrate adaptor activity | "The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274] | 3 | 0.001067 | 0 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 3 | 0.001509 | 0 |
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 3 | 0.001509 | 0 |
| GO:MF | GO:0140767 | enzyme-substrate adaptor activity | "An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity." [PMID:16250895, PMID:34358446] | 3 | 0.001838 | 0 |
| GO:MF | GO:0010997 | anaphase-promoting complex binding | "Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [GOC:BHF, GOC:dph, GOC:tb] | 2 | 0.001921 | 0 |
| GO:MF | GO:1990757 | ubiquitin ligase activator activity | "Binds to and increases the activity of a ubiquitin ligase." [GOC:dph, PMID:25619242] | 2 | 0.002400 | 0 |
| GO:MF | GO:0097027 | ubiquitin-protein transferase activator activity | "Binds to and increases the activity of a ubiquitin-protein transferase." [GOC:rb, PMID:18321851] | 2 | 0.006389 | 0 |
| GO:MF | GO:0055106 | ubiquitin-protein transferase regulator activity | "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl] | 2 | 0.027969 | 0 |
| GO:MF | GO:0030332 | cyclin binding | "Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] | 2 | 0.029708 | 0 |
Community 1
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000439 | transcription factor TFIIH core complex | "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] | 5 | 2.302026e-15 | 1 |
| GO:CC | GO:0005675 | transcription factor TFIIH holo complex | "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] | 5 | 3.946331e-15 | 1 |
| GO:CC | GO:0032806 | carboxy-terminal domain protein kinase complex | "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683] | 5 | 7.725241e-14 | 1 |
| GO:CC | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] | 5 | 3.277647e-13 | 1 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 5 | 5.194073e-11 | 1 |
| GO:CC | GO:0016591 | RNA polymerase II, holoenzyme | "A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters." [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii] | 5 | 2.068218e-10 | 1 |
| GO:CC | GO:0055029 | nuclear DNA-directed RNA polymerase complex | "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu] | 5 | 6.994001e-10 | 1 |
| GO:CC | GO:0000428 | DNA-directed RNA polymerase complex | "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] | 5 | 9.100342e-10 | 1 |
| GO:CC | GO:0030880 | RNA polymerase complex | "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah] | 5 | 1.032862e-09 | 1 |
| GO:CC | GO:0070985 | transcription factor TFIIK complex | "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993] | 3 | 1.221826e-09 | 1 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 5 | 2.003430e-09 | 1 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 5 | 3.258941e-09 | 1 |
| GO:CC | GO:0070516 | CAK-ERCC2 complex | "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2." [PMID:8692841, PMID:8692842] | 3 | 4.886972e-09 | 1 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 5 | 4.389570e-08 | 1 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 5 | 1.459751e-07 | 1 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 5 | 1.593924e-06 | 1 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 5 | 2.562794e-05 | 1 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 5 | 3.112752e-05 | 1 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 5 | 7.357385e-04 | 1 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 5 | 5.697932e-03 | 1 |
| GO:CC | GO:0000112 | nucleotide-excision repair factor 3 complex | "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p)." [GOC:ew, PMID:10915862, PMID:14500720, PMID:7813015] | 1 | 4.994332e-02 | 1 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1036 | TFIIH transcription factor complex | TFIIH transcription factor complex | 5 | 1.156204e-12 | 1 |
| CORUM | CORUM:107 | TFIIH transcription factor complex | TFIIH transcription factor complex | 5 | 1.156204e-12 | 1 |
| CORUM | CORUM:1029 | TFIIH transcription factor complex | TFIIH transcription factor complex | 5 | 2.312408e-12 | 1 |
| CORUM | CORUM:1009 | TFIIH transcription factor complex | TFIIH transcription factor complex | 5 | 2.312408e-12 | 1 |
| CORUM | CORUM:1010 | CAK complex (Cdk-activating kinase complex) | CAK complex (Cdk-activating kinase complex) | 3 | 5.240090e-08 | 1 |
| CORUM | CORUM:1008 | CAK complex (Cdk-activating kinase complex) | CAK complex (Cdk-activating kinase complex) | 3 | 5.240090e-08 | 1 |
| CORUM | CORUM:2660 | CAK-ERCC2 complex | CAK-ERCC2 complex | 3 | 2.095106e-07 | 1 |
| CORUM | CORUM:1030 | CAK-ERCC2 complex | CAK-ERCC2 complex | 3 | 2.095106e-07 | 1 |
| CORUM | CORUM:2657 | ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex | ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex | 3 | 1.046623e-06 | 1 |
| CORUM | CORUM:1007 | CAK core complex (Cdk-activating kinase core complex) | CAK core complex (Cdk-activating kinase core complex) | 2 | 5.905582e-05 | 1 |
| CORUM | CORUM:1037 | TFIIH transcription factor core complex | TFIIH transcription factor core complex | 2 | 5.895106e-04 | 1 |
| CORUM | CORUM:103 | RNA polymerase II holoenzyme complex | RNA polymerase II holoenzyme complex | 2 | 9.997352e-03 | 1 |
| CORUM | CORUM:2825 | BRCA1-RNA polymerase II complex | BRCA1-RNA polymerase II complex | 2 | 1.226289e-02 | 1 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | RNA Pol II CTD phosphorylation and interaction with CE | 5 | 9.715975e-12 | 1 |
| REAC | REAC:R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 5 | 9.715975e-12 | 1 |
| REAC | REAC:R-HSA-72086 | mRNA Capping | mRNA Capping | 5 | 1.451636e-11 | 1 |
| REAC | REAC:R-HSA-73863 | RNA Polymerase I Transcription Termination | RNA Polymerase I Transcription Termination | 5 | 2.509655e-11 | 1 |
| REAC | REAC:R-HSA-113418 | Formation of the Early Elongation Complex | Formation of the Early Elongation Complex | 5 | 2.974406e-11 | 1 |
| REAC | REAC:R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | Formation of the HIV-1 Early Elongation Complex | 5 | 2.974406e-11 | 1 |
| REAC | REAC:R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | Tat-mediated elongation of the HIV-1 transcript | 5 | 1.256471e-10 | 1 |
| REAC | REAC:R-HSA-167169 | HIV Transcription Elongation | HIV Transcription Elongation | 5 | 1.256471e-10 | 1 |
| REAC | REAC:R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5 | 1.256471e-10 | 1 |
| REAC | REAC:R-HSA-5696395 | Formation of Incision Complex in GG-NER | Formation of Incision Complex in GG-NER | 5 | 1.421797e-10 | 1 |
| REAC | REAC:R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | Formation of HIV elongation complex in the absence of HIV Tat | 5 | 1.604078e-10 | 1 |
| REAC | REAC:R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | RNA Polymerase II HIV Promoter Escape | 5 | 2.024660e-10 | 1 |
| REAC | REAC:R-HSA-167161 | HIV Transcription Initiation | HIV Transcription Initiation | 5 | 2.024660e-10 | 1 |
| REAC | REAC:R-HSA-73776 | RNA Polymerase II Promoter Escape | RNA Polymerase II Promoter Escape | 5 | 2.024660e-10 | 1 |
| REAC | REAC:R-HSA-75953 | RNA Polymerase II Transcription Initiation | RNA Polymerase II Transcription Initiation | 5 | 2.024660e-10 | 1 |
| REAC | REAC:R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 5 | 2.024660e-10 | 1 |
| REAC | REAC:R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | RNA Polymerase II Transcription Initiation And Promoter Clearance | 5 | 2.024660e-10 | 1 |
| REAC | REAC:R-HSA-73762 | RNA Polymerase I Transcription Initiation | RNA Polymerase I Transcription Initiation | 5 | 2.265691e-10 | 1 |
| REAC | REAC:R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | Formation of TC-NER Pre-Incision Complex | 5 | 3.129495e-10 | 1 |
| REAC | REAC:R-HSA-75955 | RNA Polymerase II Transcription Elongation | RNA Polymerase II Transcription Elongation | 5 | 6.184527e-10 | 1 |
| REAC | REAC:R-HSA-112382 | Formation of RNA Pol II elongation complex | Formation of RNA Pol II elongation complex | 5 | 6.184527e-10 | 1 |
| REAC | REAC:R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | Gap-filling DNA repair synthesis and ligation in TC-NER | 5 | 8.787134e-10 | 1 |
| REAC | REAC:R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | TP53 Regulates Transcription of DNA Repair Genes | 5 | 8.787134e-10 | 1 |
| REAC | REAC:R-HSA-6782135 | Dual incision in TC-NER | Dual incision in TC-NER | 5 | 9.557935e-10 | 1 |
| REAC | REAC:R-HSA-167172 | Transcription of the HIV genome | Transcription of the HIV genome | 5 | 1.659974e-09 | 1 |
| REAC | REAC:R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5 | 2.549283e-09 | 1 |
| REAC | REAC:R-HSA-674695 | RNA Polymerase II Pre-transcription Events | RNA Polymerase II Pre-transcription Events | 5 | 3.550809e-09 | 1 |
| REAC | REAC:R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | Global Genome Nucleotide Excision Repair (GG-NER) | 5 | 4.559923e-09 | 1 |
| REAC | REAC:R-HSA-73772 | RNA Polymerase I Promoter Escape | RNA Polymerase I Promoter Escape | 5 | 6.491487e-09 | 1 |
| REAC | REAC:R-HSA-427413 | NoRC negatively regulates rRNA expression | NoRC negatively regulates rRNA expression | 5 | 1.426240e-08 | 1 |
| REAC | REAC:R-HSA-5696398 | Nucleotide Excision Repair | Nucleotide Excision Repair | 5 | 1.570221e-08 | 1 |
| REAC | REAC:R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | Negative epigenetic regulation of rRNA expression | 5 | 1.646445e-08 | 1 |
| REAC | REAC:R-HSA-73854 | RNA Polymerase I Promoter Clearance | RNA Polymerase I Promoter Clearance | 5 | 1.725601e-08 | 1 |
| REAC | REAC:R-HSA-73864 | RNA Polymerase I Transcription | RNA Polymerase I Transcription | 5 | 1.807773e-08 | 1 |
| REAC | REAC:R-HSA-162599 | Late Phase of HIV Life Cycle | Late Phase of HIV Life Cycle | 5 | 4.568773e-08 | 1 |
| REAC | REAC:R-HSA-162587 | HIV Life Cycle | HIV Life Cycle | 5 | 7.358432e-08 | 1 |
| REAC | REAC:R-HSA-212165 | Epigenetic regulation of gene expression | Epigenetic regulation of gene expression | 5 | 2.525817e-07 | 1 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 5 | 6.940777e-07 | 1 |
| REAC | REAC:R-HSA-73894 | DNA Repair | DNA Repair | 5 | 4.601821e-06 | 1 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 5 | 7.137322e-06 | 1 |
| REAC | REAC:R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | Cyclin A/B1/B2 associated events during G2/M transition | 3 | 2.316315e-05 | 1 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 3 | 1.440440e-04 | 1 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 3 | 1.440440e-04 | 1 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 5 | 2.189643e-04 | 1 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 5 | 6.170199e-04 | 1 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 3 | 7.829516e-04 | 1 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 3 | 8.421670e-04 | 1 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 5 | 1.647171e-03 | 1 |
| REAC | REAC:R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3 | 3.070067e-03 | 1 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 3 | 3.215359e-03 | 1 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 5 | 3.493521e-03 | 1 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 3 | 4.638115e-03 | 1 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 5 | 5.580834e-03 | 1 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 3 | 6.081816e-03 | 1 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 5 | 9.856128e-03 | 1 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 3 | 1.075545e-02 | 1 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 3 | 1.108674e-02 | 1 |
| REAC | REAC:R-HSA-8878171 | Transcriptional regulation by RUNX1 | Transcriptional regulation by RUNX1 | 3 | 1.825219e-02 | 1 |
| REAC | REAC:R-HSA-1643685 | Disease | Disease | 5 | 2.603032e-02 | 1 |
| REAC | REAC:R-HSA-5696400 | Dual Incision in GG-NER | Dual Incision in GG-NER | 2 | 2.668515e-02 | 1 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03022 | Basal transcription factors | Basal transcription factors | 5 | 1.289748e-10 | 1 |
| KEGG | KEGG:03420 | Nucleotide excision repair | Nucleotide excision repair | 5 | 7.971030e-10 | 1 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP405 | Eukaryotic transcription initiation | Eukaryotic transcription initiation | 5 | 1.685855e-10 | 1 |
| WP | WP:WP4753 | Nucleotide excision repair | Nucleotide excision repair | 5 | 2.165472e-10 | 1 |
| WP | WP:WP5114 | Nucleotide excision repair in xeroderma pigmentosum | Nucleotide excision repair in xeroderma pigmentosum | 5 | 3.623847e-09 | 1 |
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 5 | 4.108630e-08 | 1 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 3 | 3.549380e-04 | 1 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006367 | transcription initiation at RNA polymerase II promoter | "A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH] | 5 | 2.663239e-08 | 1 |
| GO:BP | GO:0006352 | DNA-templated transcription initiation | "The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161] | 5 | 7.521755e-08 | 1 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 2.251744e-04 | 1 |
| GO:BP | GO:0006289 | nucleotide-excision repair | "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] | 3 | 4.680757e-04 | 1 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 6.549997e-04 | 1 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 4 | 6.611534e-04 | 1 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 1.153738e-03 | 1 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 4 | 1.576229e-03 | 1 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 2.795080e-03 | 1 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 4 | 2.921058e-03 | 1 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 4.520069e-03 | 1 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 4 | 5.265069e-03 | 1 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 4 | 6.031093e-03 | 1 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 3 | 6.836153e-03 | 1 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 3 | 1.008925e-02 | 1 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 4 | 1.233960e-02 | 1 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 4 | 1.324229e-02 | 1 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 4 | 1.981062e-02 | 1 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 4 | 2.703565e-02 | 1 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 5 | 2.819015e-02 | 1 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 3 | 0.000094 | 1 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 3 | 0.000094 | 1 |
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 2 | 0.011091 | 1 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 3 | 0.040229 | 1 |
Community 2
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005759 | mitochondrial matrix | "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] | 3 | 0.002293 | 2 |
Community 4
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6755-5p | hsa-mir-6755-5p | hsa-mir-6755-5p | 2 | 0.000616 | 4 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0012507 | ER to Golgi transport vesicle membrane | "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] | 2 | 0.001593 | 4 |
| GO:CC | GO:0030134 | COPII-coated ER to Golgi transport vesicle | "A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII] | 2 | 0.003728 | 4 |
| GO:CC | GO:0032580 | Golgi cisterna membrane | "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah] | 2 | 0.003896 | 4 |
| GO:CC | GO:0031985 | Golgi cisterna | "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah] | 2 | 0.006317 | 4 |
| GO:CC | GO:0005795 | Golgi stack | "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] | 2 | 0.010402 | 4 |
| GO:CC | GO:0030662 | coated vesicle membrane | "The lipid bilayer surrounding a coated vesicle." [GOC:mah] | 2 | 0.018523 | 4 |
| GO:CC | GO:0030658 | transport vesicle membrane | "The lipid bilayer surrounding a transport vesicle." [GOC:mah] | 2 | 0.029673 | 4 |
| GO:CC | GO:0030135 | coated vesicle | "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] | 2 | 0.046916 | 4 |
Community 5
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1900163 | positive regulation of phospholipid scramblase activity | "Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie] | 1 | 0.049542 | 5 |
| GO:BP | GO:2000753 | positive regulation of glucosylceramide catabolic process | "Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process." [GOC:BHF] | 1 | 0.049542 | 5 |
Community 7
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP707 | DNA damage response | DNA damage response | 2 | 0.002664 | 7 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 2 | 0.002984 | 7 |
| WP | WP:WP179 | Cell cycle | Cell cycle | 2 | 0.008107 | 7 |
| WP | WP:WP3938 | miR 222 in exercise induced cardiac growth | miR 222 in exercise induced cardiac growth | 1 | 0.039736 | 7 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 2 | 0.002780 | 7 |
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 2 | 0.006656 | 7 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 2 | 0.006656 | 7 |
| GO:MF | GO:0019914 | cyclin-dependent protein kinase activating kinase regulator activity | "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase." [GOC:ai] | 1 | 0.049891 | 7 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04068 | FoxO signaling pathway | FoxO signaling pathway | 2 | 0.006260 | 7 |
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 2 | 0.009003 | 7 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1656 | p27-cyclinE-CDK2 complex | p27-cyclinE-CDK2 complex | 1 | 0.024966 | 7 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12336 | Factor: BCL-6B; motif: NCGTAATCTAGGAATN | Factor: BCL-6B; motif: NCGTAATCTAGGAATN | 1 | 0.049771 | 7 |
Community 8
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4723 | Omega 3 omega 6 fatty acid synthesis | Omega 3 omega 6 fatty acid synthesis | 2 | 0.000119 | 8 |
| WP | WP:WP5064 | 7 oxo C and 7 beta HC pathways | 7 oxo C and 7 beta HC pathways | 2 | 0.000399 | 8 |
| WP | WP:WP5329 | Cholesterol biosynthesis pathway in hepatocytes | Cholesterol biosynthesis pathway in hepatocytes | 2 | 0.001025 | 8 |
| WP | WP:WP4545 | Oxysterols derived from cholesterol | Oxysterols derived from cholesterol | 2 | 0.001448 | 8 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:01040 | Biosynthesis of unsaturated fatty acids | Biosynthesis of unsaturated fatty acids | 2 | 0.000258 | 8 |
| KEGG | KEGG:00062 | Fatty acid elongation | Fatty acid elongation | 2 | 0.000258 | 8 |
| KEGG | KEGG:04913 | Ovarian steroidogenesis | Ovarian steroidogenesis | 2 | 0.000937 | 8 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047617 | fatty acyl-CoA hydrolase activity | "Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+." [RHEA:16781] | 2 | 0.000680 | 8 |
| GO:MF | GO:0016289 | acyl-CoA hydrolase activity | "Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+." [RHEA:70423] | 2 | 0.000739 | 8 |
| GO:MF | GO:0016790 | thiolester hydrolase activity | "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-] | 2 | 0.002225 | 8 |
| GO:MF | GO:0160215 | deacylase activity | "Catalysis of the reaction: R-CO-X + H2O = R-COOH + HX, hydrolysis of an acyl group or groups from a substrate molecule." [PMID:2760018, PMID:29637793, PMID:38355760] | 2 | 0.006656 | 8 |
| GO:MF | GO:0052689 | carboxylic ester hydrolase activity | "Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators] | 2 | 0.030566 | 8 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0000038 | very long-chain fatty acid metabolic process | "The chemical reactions and pathways involving a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [GOC:hjd] | 2 | 0.001402 | 8 |
| GO:BP | GO:0006637 | acyl-CoA metabolic process | "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732] | 2 | 0.010971 | 8 |
| GO:BP | GO:0035383 | thioester metabolic process | "The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol." [GOC:bf, Wikipedia:Thioester] | 2 | 0.010971 | 8 |
| GO:BP | GO:0001676 | long-chain fatty acid metabolic process | "The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:ajp] | 2 | 0.013869 | 8 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | Mitochondrial Fatty Acid Beta-Oxidation | 2 | 0.003022 | 8 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M11878 | Factor: Pax-8; motif: NNGTCRCGCWTSANYGMNYN | Factor: Pax-8; motif: NNGTCRCGCWTSANYGMNYN | 2 | 0.035586 | 8 |
Community 9
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0034693 | U11/U12 snRNP | "A ribonucleoprotein complex that is formed by the association of the U11 and U12 small nuclear ribonucleoproteins." [GOC:mah, PMID:15146077] | 1 | 0.020616 | 9 |
Community 11
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0003375 | Narrow greater sciatic notch | A narrowing of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium. | 2 | 0.007607 | 11 |
| HP | HP:0010456 | Abnormal greater sciatic notch morphology | An abnormality of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium. | 2 | 0.008367 | 11 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M10934 | Factor: MIXL1; motif: TAATYNRATTA | Factor: MIXL1; motif: TAATYNRATTA | 2 | 0.015676 | 11 |
| TF | TF:M10934_1 | Factor: MIXL1; motif: TAATYNRATTA; match class: 1 | Factor: MIXL1; motif: TAATYNRATTA; match class: 1 | 2 | 0.015676 | 11 |
| TF | TF:M07378_1 | Factor: cdx; motif: NNTTTATNN; match class: 1 | Factor: cdx; motif: NNTTTATNN; match class: 1 | 2 | 0.036007 | 11 |
Community 12
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06974 | Factor: PRRX2; motif: WTAATCTGATTAT | Factor: PRRX2; motif: WTAATCTGATTAT | 1 | 0.049771 | 12 |
Community 13
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6862 | Bag6-Ubl4A-Trc35 Complex | Bag6-Ubl4A-Trc35 Complex | 1 | 0.049932 | 13 |
Community 14
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:1903018 | regulation of glycoprotein metabolic process | "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] | 2 | 0.001932 | 14 |
Community 15
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04142 | Lysosome | Lysosome | 2 | 0.006260 | 15 |
| KEGG | KEGG:03265 | Virion - Ebolavirus and Lyssavirus | Virion - Ebolavirus and Lyssavirus | 1 | 0.037408 | 15 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0007034 | vacuolar transport | "The directed movement of substances into, out of or within a vacuole." [GOC:ai] | 2 | 0.035465 | 15 |
| GO:BP | GO:0016241 | regulation of macroautophagy | "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] | 2 | 0.039671 | 15 |
| GO:BP | GO:2000900 | cyclodextrin metabolic process | "The chemical reactions and pathways involving a cyclodextrin." [GOC:mengo_curators] | 1 | 0.049542 | 15 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0033181 | plasma membrane proton-transporting V-type ATPase complex | "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah] | 1 | 0.041231 | 15 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:6000158 | Unesterified cholesterol accumulation in cultured fibroblasts | An abnormal result of the filipin test. This test is based on the reaction of unesterified cholesterol with fluorescent antibiotic filipin giving a strongly fluorescent, stable cholesterol-filipin complex suitable for in situ detection. An abnormal test result is present if there is a perinuclear accumulation of staining in lysosomal storage organelles (LSOs). | 1 | 0.049962 | 15 |
Community 17
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:rno-mir-204-5p | rno-mir-204-5p | rno-mir-204-5p | 1 | 0.002260 | 17 |
| MIRNA | MIRNA:hsa-mir-664b-5p | hsa-mir-664b-5p | hsa-mir-664b-5p | 1 | 0.036152 | 17 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4284 | Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer | Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer | 1 | 0.012487 | 17 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0097135 | cyclin E2-CDK2 complex | "A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 1 | 0.019977 | 17 |
| GO:CC | GO:0097134 | cyclin E1-CDK2 complex | "A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] | 1 | 0.029966 | 17 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12420 | Factor: ZNF528; motif: CCCAGGGAAGCCATTTC | Factor: ZNF528; motif: CCCAGGGAAGCCATTTC | 1 | 0.037328 | 17 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | 1 | 0.049932 | 17 |
Community 20
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047620 | acylglycerol kinase activity | "Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate." [EC:2.7.1.94, MetaCyc:ACYLGLYCEROL-KINASE-RXN] | 1 | 0.024946 | 20 |
| GO:MF | GO:0001729 | ceramide kinase activity | "Catalysis of the reaction: an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H+." [EC:2.7.1.138] | 1 | 0.049891 | 20 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0004901 | Exercise-induced lactic acidemia | A form of lactic acidemia that occurs following exercise or exertion. | 1 | 0.049962 | 20 |
Community 21
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M12459_1 | Factor: TCF12; motif: NNCACCTGCNN; match class: 1 | Factor: TCF12; motif: NNCACCTGCNN; match class: 1 | 1 | 0.024886 | 21 |
Community 23
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M06304 | Factor: ZNF260; motif: YTAAMCGGGAATACCTA | Factor: ZNF260; motif: YTAAMCGGGAATACCTA | 1 | 0.012443 | 23 |
Community 28
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0000140 | acylglycerone-phosphate reductase (NADP+) activity | "Catalysis of the reaction: 1-hexadecanoyl-sn-glycero-3-phosphate + NADP+ = 1-hexadecanoylglycerone 3-phosphate + H+ + NADPH." [RHEA:17341] | 1 | 0.024946 | 28 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-75896 | Plasmalogen biosynthesis | Plasmalogen biosynthesis | 1 | 0.037449 | 28 |
Community 29
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-664b-5p | hsa-mir-664b-5p | hsa-mir-664b-5p | 1 | 0.036152 | 29 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0031267 | Abnormal CD69 upregulation upon TCR activation | Any abnormality in the upregulation of CD69 on T cells after activation via the T cell receptor (TCR). Upregulation of CD69 is one of the earliest and most sensitive measures of antigen recognition in the periphery, and transient expression of CD69 is associated with positive selection in the thymus. | 1 | 0.049962 | 29 |
| HP | HP:0031268 | Decreased CD69 upregulation upon TCR activation | Reduced or impaired upregulation of CD69 on T cells after activation via the T cell receptor (TCR). | 1 | 0.049962 | 29 |
| HP | HP:0032204 | Chronic active Epstein-Barr virus infection | Chronic active Epstein-Barr virus (EBV) infection is an uncommon outcome of EBV infection and may present as a waxing and waning or fulminant syndrome. Unlike acute infectious mononucleosis, wherein EBV establishes lifelong infection and survives by maintaining a delicate balance with the host as a latent infection, in chronic active EBV infection the host-virus balance is disturbed. | 1 | 0.049962 | 29 |
Community 32
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-6850-5p | hsa-mir-6850-5p | hsa-mir-6850-5p | 1 | 0.009038 | 32 |
| MIRNA | MIRNA:hsa-mir-5188 | hsa-mir-5188 | hsa-mir-5188 | 1 | 0.018076 | 32 |
| MIRNA | MIRNA:hsa-mir-6786-3p | hsa-mir-6786-3p | hsa-mir-6786-3p | 1 | 0.038412 | 32 |
| MIRNA | MIRNA:hsa-mir-5739 | hsa-mir-5739 | hsa-mir-5739 | 1 | 0.049710 | 32 |
Community 35
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6218 | POL2R-SYMPK-SSU72 complex | POL2R-SYMPK-SSU72 complex | 1 | 0.049932 | 35 |
Community 36
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M04057 | Factor: NFIB; motif: TTGGCANNNTGCCAR | Factor: NFIB; motif: TTGGCANNNTGCCAR | 1 | 0.012443 | 36 |
Community 37
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M05607 | Factor: A-Myb; motif: AGTAACGGMKWT | Factor: A-Myb; motif: AGTAACGGMKWT | 1 | 0.049771 | 37 |
Community 39
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0032798 | Swi5-Sfr1 complex | "A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces)." [PMID:15620352, PMID:16921379] | 1 | 0.009989 | 39 |
Community 40
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4238 | Flavan 3 ol metabolic pathway | Flavan 3 ol metabolic pathway | 1 | 0.006244 | 40 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-379398 | Enzymatic degradation of Dopamine by monoamine oxidase | Enzymatic degradation of Dopamine by monoamine oxidase | 1 | 0.024966 | 40 |
| REAC | REAC:R-HSA-379397 | Enzymatic degradation of dopamine by COMT | Enzymatic degradation of dopamine by COMT | 1 | 0.037449 | 40 |
| REAC | REAC:R-HSA-379401 | Dopamine clearance from the synaptic cleft | Dopamine clearance from the synaptic cleft | 1 | 0.049932 | 40 |
Community 42
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0120220 | basal body patch | "The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster." [GOC:krc, PMID:20164345, PMID:20685736, PMID:29891944] | 1 | 0.009989 | 42 |
| GO:CC | GO:0097433 | dense body | "An electron dense body which may contain granules." [ISBN:0195065719, NIF_Subcellular:sao730872736] | 1 | 0.049943 | 42 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2254 | CTGF/Hcs24-actin(beta/gamma) complex | CTGF/Hcs24-actin(beta/gamma) complex | 1 | 0.049932 | 42 |
Community 43
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:2205 | ORC5-ORC1 complex | ORC5-ORC1 complex | 1 | 0.049932 | 43 |
WashU (Louvain)
Community 0
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:6888 | v-ATPase-Ragulator-AXIN/LKB1-AMPK complex | v-ATPase-Ragulator-AXIN/LKB1-AMPK complex | 2 | 0.003991 | 0 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005737 | cytoplasm | "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] | 26 | 0.005977 | 0 |
| GO:CC | GO:0098588 | bounding membrane of organelle | "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] | 11 | 0.010137 | 0 |
| GO:CC | GO:0030659 | cytoplasmic vesicle membrane | "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] | 8 | 0.023972 | 0 |
| GO:CC | GO:0005856 | cytoskeleton | "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] | 11 | 0.024193 | 0 |
| GO:CC | GO:0012506 | vesicle membrane | "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] | 8 | 0.026626 | 0 |
| GO:CC | GO:0032580 | Golgi cisterna membrane | "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah] | 3 | 0.044083 | 0 |
| GO:CC | GO:0098852 | lytic vacuole membrane | "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos] | 5 | 0.047805 | 0 |
| GO:CC | GO:0005765 | lysosomal membrane | "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] | 5 | 0.047805 | 0 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0190222 | Esophagus; squamous epithelial cells[≥Medium] | Esophagus; squamous epithelial cells[≥Medium] | 17 | 0.015522 | 0 |
| HPA | HPA:0250000 | Hippocampus | Hippocampus | 19 | 0.017875 | 0 |
| HPA | HPA:0310441 | Lymph node; non-germinal center cells[≥Low] | Lymph node; non-germinal center cells[≥Low] | 18 | 0.031010 | 0 |
| HPA | HPA:0470000 | Skin 2 | Skin 2 | 19 | 0.031326 | 0 |
| HPA | HPA:0150052 | Duodenum; glandular cells[≥Medium] | Duodenum; glandular cells[≥Medium] | 18 | 0.034763 | 0 |
| HPA | HPA:0590051 | Thyroid gland; glandular cells[≥Low] | Thyroid gland; glandular cells[≥Low] | 19 | 0.040024 | 0 |
| HPA | HPA:0590000 | Thyroid gland | Thyroid gland | 19 | 0.040024 | 0 |
| HPA | HPA:0250131 | Hippocampus; neuronal cells[≥Low] | Hippocampus; neuronal cells[≥Low] | 18 | 0.048194 | 0 |
Community 1
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP179 | Cell cycle | Cell cycle | 13 | 2.270294e-20 | 1 |
| WP | WP:WP2446 | Retinoblastoma gene in cancer | Retinoblastoma gene in cancer | 8 | 1.347285e-10 | 1 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 6 | 1.226624e-07 | 1 |
| WP | WP:WP707 | DNA damage response | DNA damage response | 5 | 1.447180e-05 | 1 |
| WP | WP:WP1530 | miRNA regulation of DNA damage response | miRNA regulation of DNA damage response | 5 | 1.926033e-05 | 1 |
| WP | WP:WP4658 | Small cell lung cancer | Small cell lung cancer | 5 | 7.259302e-05 | 1 |
| WP | WP:WP5180 | DYRK1A involvement regarding cell proliferation in brain development | DYRK1A involvement regarding cell proliferation in brain development | 4 | 5.254900e-04 | 1 |
| WP | WP:WP5434 | Cancer pathways | Cancer pathways | 7 | 1.995484e-03 | 1 |
| WP | WP:WP3391 | Senescence associated secretory phenotype SASP | Senescence associated secretory phenotype SASP | 4 | 5.536829e-03 | 1 |
| WP | WP:WP1971 | Integrated cancer pathway | Integrated cancer pathway | 3 | 8.549103e-03 | 1 |
| WP | WP:WP5491 | Transcriptional regulation of memory B cell differentiation | Transcriptional regulation of memory B cell differentiation | 3 | 9.776963e-03 | 1 |
| WP | WP:WP2586 | Aryl hydrocarbon receptor pathway | Aryl hydrocarbon receptor pathway | 3 | 9.776963e-03 | 1 |
| WP | WP:WP236 | Adipogenesis | Adipogenesis | 4 | 9.926946e-03 | 1 |
| WP | WP:WP2864 | Apoptosis related network due to altered Notch3 in ovarian cancer | Apoptosis related network due to altered Notch3 in ovarian cancer | 3 | 1.497056e-02 | 1 |
| WP | WP:WP4685 | Melanoma | Melanoma | 3 | 3.149531e-02 | 1 |
| WP | WP:WP1545 | miRNAs involved in DNA damage response | miRNAs involved in DNA damage response | 3 | 3.149531e-02 | 1 |
| WP | WP:WP4255 | Non small cell lung cancer | Non small cell lung cancer | 3 | 3.731367e-02 | 1 |
| WP | WP:WP4970 | Galanin receptor pathway | Galanin receptor pathway | 2 | 4.992714e-02 | 1 |
| WP | WP:WP53 | ID signaling | ID signaling | 2 | 4.992714e-02 | 1 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:04110 | Cell cycle | Cell cycle | 13 | 1.166716e-19 | 1 |
| KEGG | KEGG:04218 | Cellular senescence | Cellular senescence | 9 | 5.197498e-11 | 1 |
| KEGG | KEGG:05203 | Viral carcinogenesis | Viral carcinogenesis | 8 | 3.060485e-08 | 1 |
| KEGG | KEGG:05222 | Small cell lung cancer | Small cell lung cancer | 6 | 4.049050e-07 | 1 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | Epstein-Barr virus infection | 7 | 1.182543e-06 | 1 |
| KEGG | KEGG:05215 | Prostate cancer | Prostate cancer | 5 | 3.065255e-05 | 1 |
| KEGG | KEGG:05165 | Human papillomavirus infection | Human papillomavirus infection | 7 | 3.944740e-05 | 1 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | Human T-cell leukemia virus 1 infection | 6 | 7.031517e-05 | 1 |
| KEGG | KEGG:04068 | FoxO signaling pathway | FoxO signaling pathway | 5 | 1.368588e-04 | 1 |
| KEGG | KEGG:05226 | Gastric cancer | Gastric cancer | 5 | 2.499116e-04 | 1 |
| KEGG | KEGG:04934 | Cushing syndrome | Cushing syndrome | 5 | 2.942766e-04 | 1 |
| KEGG | KEGG:05161 | Hepatitis B | Hepatitis B | 5 | 3.895787e-04 | 1 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | Chronic myeloid leukemia | 4 | 4.779487e-04 | 1 |
| KEGG | KEGG:05200 | Pathways in cancer | Pathways in cancer | 7 | 9.037444e-04 | 1 |
| KEGG | KEGG:01522 | Endocrine resistance | Endocrine resistance | 4 | 1.162703e-03 | 1 |
| KEGG | KEGG:05219 | Bladder cancer | Bladder cancer | 3 | 2.905262e-03 | 1 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | MicroRNAs in cancer | 5 | 8.882705e-03 | 1 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | Non-small cell lung cancer | 3 | 1.572729e-02 | 1 |
| KEGG | KEGG:05218 | Melanoma | Melanoma | 3 | 1.572729e-02 | 1 |
| KEGG | KEGG:05214 | Glioma | Glioma | 3 | 1.774988e-02 | 1 |
| KEGG | KEGG:05212 | Pancreatic cancer | Pancreatic cancer | 3 | 1.845969e-02 | 1 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | Progesterone-mediated oocyte maturation | 3 | 4.385586e-02 | 1 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 11 | 2.003756e-16 | 1 |
| REAC | REAC:R-HSA-69278 | Cell Cycle, Mitotic | Cell Cycle, Mitotic | 13 | 4.408171e-14 | 1 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 8 | 5.548555e-14 | 1 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 8 | 5.548555e-14 | 1 |
| REAC | REAC:R-HSA-1640170 | Cell Cycle | Cell Cycle | 13 | 7.097056e-13 | 1 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 9 | 2.206137e-12 | 1 |
| REAC | REAC:R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | Aberrant regulation of mitotic cell cycle due to RB1 defects | 7 | 2.320412e-12 | 1 |
| REAC | REAC:R-HSA-9675126 | Diseases of mitotic cell cycle | Diseases of mitotic cell cycle | 7 | 3.504148e-12 | 1 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 8 | 7.554862e-12 | 1 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 9 | 1.556065e-11 | 1 |
| REAC | REAC:R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | TP53 Regulates Transcription of Cell Cycle Genes | 7 | 2.370511e-11 | 1 |
| REAC | REAC:R-HSA-1538133 | G0 and Early G1 | G0 and Early G1 | 6 | 8.830555e-11 | 1 |
| REAC | REAC:R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 5 | 9.443974e-10 | 1 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 7 | 1.029941e-09 | 1 |
| REAC | REAC:R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 5 | 1.415630e-09 | 1 |
| REAC | REAC:R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 5 | 2.913076e-09 | 1 |
| REAC | REAC:R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 5 | 2.913076e-09 | 1 |
| REAC | REAC:R-HSA-2559583 | Cellular Senescence | Cellular Senescence | 7 | 4.678519e-07 | 1 |
| REAC | REAC:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | SCF(Skp2)-mediated degradation of p27/p21 | 5 | 2.496615e-06 | 1 |
| REAC | REAC:R-HSA-68911 | G2 Phase | G2 Phase | 3 | 5.213604e-06 | 1 |
| REAC | REAC:R-HSA-69205 | G1/S-Specific Transcription | G1/S-Specific Transcription | 4 | 9.010657e-06 | 1 |
| REAC | REAC:R-HSA-69052 | Switching of origins to a post-replicative state | Switching of origins to a post-replicative state | 5 | 2.199293e-05 | 1 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 7 | 3.329926e-05 | 1 |
| REAC | REAC:R-HSA-212436 | Generic Transcription Pathway | Generic Transcription Pathway | 10 | 6.337694e-05 | 1 |
| REAC | REAC:R-HSA-69239 | Synthesis of DNA | Synthesis of DNA | 5 | 8.715223e-05 | 1 |
| REAC | REAC:R-HSA-73857 | RNA Polymerase II Transcription | RNA Polymerase II Transcription | 10 | 1.549565e-04 | 1 |
| REAC | REAC:R-HSA-69620 | Cell Cycle Checkpoints | Cell Cycle Checkpoints | 6 | 2.495951e-04 | 1 |
| REAC | REAC:R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | FOXO-mediated transcription of cell cycle genes | 3 | 3.513472e-04 | 1 |
| REAC | REAC:R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | p53-Dependent G1/S DNA damage checkpoint | 4 | 3.596663e-04 | 1 |
| REAC | REAC:R-HSA-69563 | p53-Dependent G1 DNA Damage Response | p53-Dependent G1 DNA Damage Response | 4 | 3.596663e-04 | 1 |
| REAC | REAC:R-HSA-69615 | G1/S DNA Damage Checkpoints | G1/S DNA Damage Checkpoints | 4 | 4.058161e-04 | 1 |
| REAC | REAC:R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | Transcription of E2F targets under negative control by DREAM complex | 3 | 4.213004e-04 | 1 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 10 | 4.556622e-04 | 1 |
| REAC | REAC:R-HSA-2262752 | Cellular responses to stress | Cellular responses to stress | 8 | 4.678891e-04 | 1 |
| REAC | REAC:R-HSA-8953897 | Cellular responses to stimuli | Cellular responses to stimuli | 8 | 5.343758e-04 | 1 |
| REAC | REAC:R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | DNA Damage/Telomere Stress Induced Senescence | 4 | 7.427246e-04 | 1 |
| REAC | REAC:R-HSA-69306 | DNA Replication | DNA Replication | 5 | 7.564330e-04 | 1 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 5 | 1.002086e-03 | 1 |
| REAC | REAC:R-HSA-453276 | Regulation of mitotic cell cycle | Regulation of mitotic cell cycle | 4 | 1.145163e-03 | 1 |
| REAC | REAC:R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | APC/C-mediated degradation of cell cycle proteins | 4 | 1.145163e-03 | 1 |
| REAC | REAC:R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | Senescence-Associated Secretory Phenotype (SASP) | 4 | 2.892114e-03 | 1 |
| REAC | REAC:R-HSA-176417 | Phosphorylation of Emi1 | Phosphorylation of Emi1 | 2 | 7.159913e-03 | 1 |
| REAC | REAC:R-HSA-9614085 | FOXO-mediated transcription | FOXO-mediated transcription | 3 | 2.278952e-02 | 1 |
| REAC | REAC:R-HSA-68949 | Orc1 removal from chromatin | Orc1 removal from chromatin | 3 | 2.835776e-02 | 1 |
| REAC | REAC:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | CDK-mediated phosphorylation and removal of Cdc6 | 3 | 3.081255e-02 | 1 |
| REAC | REAC:R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 3 | 3.209036e-02 | 1 |
| REAC | REAC:R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Regulation of APC/C activators between G1/S and early anaphase | 3 | 4.201508e-02 | 1 |
| REAC | REAC:R-HSA-198323 | AKT phosphorylates targets in the cytosol | AKT phosphorylates targets in the cytosol | 2 | 4.318481e-02 | 1 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 13 | 2.795963e-16 | 1 |
| GO:BP | GO:1903047 | mitotic cell cycle process | "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] | 14 | 3.954583e-15 | 1 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 13 | 4.810759e-15 | 1 |
| GO:BP | GO:0000278 | mitotic cell cycle | "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] | 14 | 4.920862e-14 | 1 |
| GO:BP | GO:0022402 | cell cycle process | "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] | 15 | 9.633377e-14 | 1 |
| GO:BP | GO:0007049 | cell cycle | "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] | 15 | 4.801770e-12 | 1 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 9 | 1.949999e-11 | 1 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] | 9 | 6.351843e-11 | 1 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 9 | 1.528574e-09 | 1 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 9 | 1.672932e-08 | 1 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 9 | 5.920563e-08 | 1 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 8 | 3.080501e-07 | 1 |
| GO:BP | GO:0045930 | negative regulation of mitotic cell cycle | "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 7 | 3.821876e-07 | 1 |
| GO:BP | GO:1901988 | negative regulation of cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 7 | 7.547396e-07 | 1 |
| GO:BP | GO:0010564 | regulation of cell cycle process | "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 9 | 1.722188e-06 | 1 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 6 | 2.033742e-06 | 1 |
| GO:BP | GO:0010948 | negative regulation of cell cycle process | "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] | 7 | 2.191494e-06 | 1 |
| GO:BP | GO:0051726 | regulation of cell cycle | "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] | 10 | 2.686097e-06 | 1 |
| GO:BP | GO:1901991 | negative regulation of mitotic cell cycle phase transition | "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 6 | 4.637632e-06 | 1 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 6 | 5.324727e-06 | 1 |
| GO:BP | GO:0051338 | regulation of transferase activity | "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] | 7 | 9.335663e-05 | 1 |
| GO:BP | GO:0000086 | G2/M transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] | 5 | 1.002792e-04 | 1 |
| GO:BP | GO:0044839 | cell cycle G2/M phase transition | "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle] | 5 | 1.785291e-04 | 1 |
| GO:BP | GO:0000075 | cell cycle checkpoint signaling | "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] | 5 | 4.172228e-04 | 1 |
| GO:BP | GO:1905178 | regulation of cardiac muscle tissue regeneration | "Any process that modulates the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] | 2 | 9.048307e-04 | 1 |
| GO:BP | GO:1905179 | negative regulation of cardiac muscle tissue regeneration | "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] | 2 | 9.048307e-04 | 1 |
| GO:BP | GO:0090398 | cellular senescence | "A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest." [GOC:BHF, PMID:28682291] | 4 | 1.672950e-03 | 1 |
| GO:BP | GO:1905786 | positive regulation of anaphase-promoting complex-dependent catabolic process | "Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876] | 2 | 2.713201e-03 | 1 |
| GO:BP | GO:0006260 | DNA replication | "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] | 5 | 3.398635e-03 | 1 |
| GO:BP | GO:0031570 | DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] | 4 | 3.679548e-03 | 1 |
| GO:BP | GO:0007093 | mitotic cell cycle checkpoint signaling | "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] | 4 | 5.490244e-03 | 1 |
| GO:BP | GO:0050790 | regulation of catalytic activity | "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] | 7 | 6.182612e-03 | 1 |
| GO:BP | GO:0043550 | regulation of lipid kinase activity | "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf] | 2 | 9.035402e-03 | 1 |
| GO:BP | GO:1905784 | regulation of anaphase-promoting complex-dependent catabolic process | "Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876] | 2 | 9.035402e-03 | 1 |
| GO:BP | GO:0070345 | negative regulation of fat cell proliferation | "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] | 2 | 9.035402e-03 | 1 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 7 | 1.046753e-02 | 1 |
| GO:BP | GO:0051301 | cell division | "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] | 6 | 1.244193e-02 | 1 |
| GO:BP | GO:0065009 | regulation of molecular function | "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] | 8 | 1.288008e-02 | 1 |
| GO:BP | GO:0061026 | cardiac muscle tissue regeneration | "The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:dph] | 2 | 1.354666e-02 | 1 |
| GO:BP | GO:0048146 | positive regulation of fibroblast proliferation | "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] | 3 | 1.560984e-02 | 1 |
| GO:BP | GO:0044818 | mitotic G2/M transition checkpoint | "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 1.650216e-02 | 1 |
| GO:BP | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 1.742754e-02 | 1 |
| GO:BP | GO:1902807 | negative regulation of cell cycle G1/S phase transition | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 2.257041e-02 | 1 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] | 13 | 2.422176e-02 | 1 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] | 14 | 2.566475e-02 | 1 |
| GO:BP | GO:0043549 | regulation of kinase activity | "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] | 5 | 2.625431e-02 | 1 |
| GO:BP | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 3.272676e-02 | 1 |
| GO:BP | GO:0000280 | nuclear division | "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] | 5 | 3.300555e-02 | 1 |
| GO:BP | GO:1902750 | negative regulation of cell cycle G2/M phase transition | "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] | 3 | 3.566495e-02 | 1 |
| GO:BP | GO:0044774 | mitotic DNA integrity checkpoint signaling | "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle] | 3 | 4.038984e-02 | 1 |
| GO:BP | GO:0070344 | regulation of fat cell proliferation | "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] | 2 | 4.056272e-02 | 1 |
| GO:BP | GO:1904668 | positive regulation of ubiquitin protein ligase activity | "Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882] | 2 | 4.056272e-02 | 1 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 5 | 9.894530e-08 | 1 |
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 5 | 9.189413e-07 | 1 |
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 5 | 9.189413e-07 | 1 |
| GO:MF | GO:1990757 | ubiquitin ligase activator activity | "Binds to and increases the activity of a ubiquitin ligase." [GOC:dph, PMID:25619242] | 3 | 1.588946e-05 | 1 |
| GO:MF | GO:0097027 | ubiquitin-protein transferase activator activity | "Binds to and increases the activity of a ubiquitin-protein transferase." [GOC:rb, PMID:18321851] | 3 | 7.392031e-05 | 1 |
| GO:MF | GO:0019912 | cyclin-dependent protein kinase activating kinase activity | "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)." [GOC:go_curators] | 2 | 1.793536e-04 | 1 |
| GO:MF | GO:0019887 | protein kinase regulator activity | "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] | 5 | 3.342818e-04 | 1 |
| GO:MF | GO:0019207 | kinase regulator activity | "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] | 5 | 6.879704e-04 | 1 |
| GO:MF | GO:0055106 | ubiquitin-protein transferase regulator activity | "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl] | 3 | 7.138701e-04 | 1 |
| GO:MF | GO:1990756 | ubiquitin-like ligase-substrate adaptor activity | "The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274] | 3 | 5.885637e-03 | 1 |
| GO:MF | GO:0010997 | anaphase-promoting complex binding | "Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [GOC:BHF, GOC:dph, GOC:tb] | 2 | 6.434439e-03 | 1 |
| GO:MF | GO:0140767 | enzyme-substrate adaptor activity | "An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity." [PMID:16250895, PMID:34358446] | 3 | 1.010272e-02 | 1 |
| GO:MF | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity | "Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr] | 2 | 1.177900e-02 | 1 |
| GO:MF | GO:0030234 | enzyme regulator activity | "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] | 7 | 1.588341e-02 | 1 |
| GO:MF | GO:0004674 | protein serine/threonine kinase activity | "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.-, GOC:bf, PMID:2956925] | 5 | 1.967624e-02 | 1 |
| GO:MF | GO:0016301 | kinase activity | "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] | 6 | 2.989690e-02 | 1 |
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 15 | 2.336705e-07 | 1 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 9 | 8.421187e-07 | 1 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 15 | 1.073248e-05 | 1 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 4 | 2.726885e-05 | 1 |
| GO:CC | GO:0031461 | cullin-RING ubiquitin ligase complex | "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] | 5 | 3.645342e-05 | 1 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 15 | 1.616273e-04 | 1 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 15 | 1.616273e-04 | 1 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 15 | 1.616273e-04 | 1 |
| GO:CC | GO:0005634 | nucleus | "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] | 17 | 2.215945e-04 | 1 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 9 | 2.659378e-04 | 1 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 4 | 4.822465e-04 | 1 |
| GO:CC | GO:0000151 | ubiquitin ligase complex | "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] | 5 | 4.980305e-04 | 1 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 4 | 7.060828e-04 | 1 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 15 | 1.847973e-03 | 1 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 4 | 1.353644e-02 | 1 |
| GO:CC | GO:0005680 | anaphase-promoting complex | "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] | 2 | 2.019735e-02 | 1 |
| GO:CC | GO:0005813 | centrosome | "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] | 5 | 2.744807e-02 | 1 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:5144 | E2F1-p107-cyclinA complex | E2F1-p107-cyclinA complex | 3 | 0.000002 | 1 |
| CORUM | CORUM:1661 | E2F4-p107-cyclinA complex | E2F4-p107-cyclinA complex | 2 | 0.003355 | 1 |
| CORUM | CORUM:6444 | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex | 2 | 0.016704 | 1 |
| CORUM | CORUM:3015 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex | 2 | 0.016704 | 1 |
TF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| TF | TF:M13366 | Factor: ZBED4; motif: CCCGCYCCGC | Factor: ZBED4; motif: CCCGCYCCGC | 16 | 0.006434 | 1 |
| TF | TF:M07250_1 | Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 | Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 | 14 | 0.010285 | 1 |
| TF | TF:M00918 | Factor: E2F; motif: TTTSGCGSG | Factor: E2F; motif: TTTSGCGSG | 14 | 0.012046 | 1 |
| TF | TF:M00427_1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | Factor: E2F; motif: TTTSGCGS; match class: 1 | 12 | 0.013207 | 1 |
| TF | TF:M00919_1 | Factor: E2F; motif: NCSCGCSAAAN; match class: 1 | Factor: E2F; motif: NCSCGCSAAAN; match class: 1 | 8 | 0.031964 | 1 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0100522 | Thymoma | A tumor originating from the epithelial cells of the thymus. | 2 | 0.017659 | 1 |
| HP | HP:0040306 | Decreased male libido | Reduced desire for sexual activity on the part of a male. | 2 | 0.017659 | 1 |
| HP | HP:0011762 | Pituitary thyrotropic cell adenoma | A type of pituitary adenoma that produces thyroid stimulating hormone (TSH). | 2 | 0.017659 | 1 |
| HP | HP:0011759 | Pituitary gonadotropic cell adenoma | A type of pituitary adenoma that produces gonadotropins. | 2 | 0.017659 | 1 |
| HP | HP:0011761 | Pituitary null cell adenoma | A type of pituitary adenoma that is of unknown cellular origin and that lacks immunocytochemical or fine structural markers. Null cell adenomas are not associated with hormone excess. | 2 | 0.017659 | 1 |
| HP | HP:0500167 | Hypergastrinemia | An elevated amount of gastrin in the blood. | 2 | 0.026471 | 1 |
| HP | HP:0100521 | Neoplasm of the thymus | A tumor (abnormal growth of tissue) of the thymus. | 2 | 0.026471 | 1 |
| HP | HP:0030404 | Glucagonoma | An endocrine tumor of the pancreas that secretes excessive amounts of glucagon. | 2 | 0.026471 | 1 |
| HP | HP:0012197 | Insulinoma | A type of tumor of the pancreatic beta cells that secretes excess insulin and can result in hypoglycemia. | 2 | 0.026471 | 1 |
| HP | HP:0500166 | Abnormal circulating gastrin concentration | An abnormal concentration of gastrin in the blood. | 2 | 0.026471 | 1 |
| HP | HP:0005605 | Large cafe-au-lait macules with irregular margins | Large hypermelanotic macules with jagged borders. | 2 | 0.026471 | 1 |
| HP | HP:0006723 | Intestinal carcinoid | Intestinal carcinoid | 2 | 0.026471 | 1 |
| HP | HP:0006780 | Parathyroid carcinoma | A malignancy of the parathyroid glands. Parathyroid carcinoma usually secretes parathyroid hormone, leading to hyperparathyroidism. | 2 | 0.037035 | 1 |
| HP | HP:0030445 | Pulmonary carcinoid tumor | A malignant neuroendocrine tumor of the lung. According to histopathologic criteria (WHO 2004), carcinoids are divided into four groups i.e. typical and atypical carcinoids, large cell neuroendocrine carcinoma and small cell lung carcinoma. | 2 | 0.049348 | 1 |
| HP | HP:0006767 | Pituitary prolactin cell adenoma | A type of pituitary adenoma originating in prolactin secreting cells. This kind of adenoma is characterized by overproduction of prolactin, and may cause loss of menstrual periods and breast milk production in women. | 2 | 0.049348 | 1 |
MIRNA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| MIRNA | MIRNA:hsa-mir-24-3p | hsa-mir-24-3p | hsa-mir-24-3p | 6 | 0.030495 | 1 |
| MIRNA | MIRNA:hsa-mir-193b-3p | hsa-mir-193b-3p | hsa-mir-193b-3p | 6 | 0.035671 | 1 |
Community 2
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0005739 | mitochondrion | "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] | 7 | 0.000291 | 2 |
| GO:CC | GO:0005759 | mitochondrial matrix | "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] | 4 | 0.005959 | 2 |
| GO:CC | GO:0120220 | basal body patch | "The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster." [GOC:krc, PMID:20164345, PMID:20685736, PMID:29891944] | 1 | 0.049943 | 2 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP4723 | Omega 3 omega 6 fatty acid synthesis | Omega 3 omega 6 fatty acid synthesis | 2 | 0.006789 | 2 |
| WP | WP:WP5064 | 7 oxo C and 7 beta HC pathways | 7 oxo C and 7 beta HC pathways | 2 | 0.022590 | 2 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:00062 | Fatty acid elongation | Fatty acid elongation | 2 | 0.007116 | 2 |
| KEGG | KEGG:01040 | Biosynthesis of unsaturated fatty acids | Biosynthesis of unsaturated fatty acids | 2 | 0.007116 | 2 |
| KEGG | KEGG:04913 | Ovarian steroidogenesis | Ovarian steroidogenesis | 2 | 0.025654 | 2 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0047617 | fatty acyl-CoA hydrolase activity | "Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+." [RHEA:16781] | 2 | 0.010876 | 2 |
| GO:MF | GO:0016289 | acyl-CoA hydrolase activity | "Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+." [RHEA:70423] | 2 | 0.011819 | 2 |
| GO:MF | GO:0016790 | thiolester hydrolase activity | "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-] | 2 | 0.035406 | 2 |
HPA
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HPA | HPA:0310433 | Lymph node; germinal center cells[High] | Lymph node; germinal center cells[High] | 5 | 0.022173 | 2 |
| HPA | HPA:0050011 | Breast; adipocytes[≥Low] | Breast; adipocytes[≥Low] | 7 | 0.043899 | 2 |
Community 3
GO:CC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:CC | GO:0000439 | transcription factor TFIIH core complex | "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] | 5 | 8.042738e-14 | 3 |
| GO:CC | GO:0005675 | transcription factor TFIIH holo complex | "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] | 5 | 1.378599e-13 | 3 |
| GO:CC | GO:0032806 | carboxy-terminal domain protein kinase complex | "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683] | 5 | 2.696275e-12 | 3 |
| GO:CC | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] | 5 | 1.143194e-11 | 3 |
| GO:CC | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] | 5 | 1.803032e-09 | 3 |
| GO:CC | GO:0070985 | transcription factor TFIIK complex | "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993] | 3 | 4.271665e-09 | 3 |
| GO:CC | GO:0016591 | RNA polymerase II, holoenzyme | "A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters." [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii] | 5 | 7.162413e-09 | 3 |
| GO:CC | GO:0070516 | CAK-ERCC2 complex | "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2." [PMID:8692841, PMID:8692842] | 3 | 1.708377e-08 | 3 |
| GO:CC | GO:0055029 | nuclear DNA-directed RNA polymerase complex | "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu] | 5 | 2.415505e-08 | 3 |
| GO:CC | GO:0000428 | DNA-directed RNA polymerase complex | "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] | 5 | 3.140831e-08 | 3 |
| GO:CC | GO:0030880 | RNA polymerase complex | "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah] | 5 | 3.563540e-08 | 3 |
| GO:CC | GO:1902554 | serine/threonine protein kinase complex | "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] | 5 | 6.898839e-08 | 3 |
| GO:CC | GO:1902911 | protein kinase complex | "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] | 5 | 1.120440e-07 | 3 |
| GO:CC | GO:0090575 | RNA polymerase II transcription regulator complex | "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] | 5 | 1.491583e-06 | 3 |
| GO:CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] | 5 | 4.921376e-06 | 3 |
| GO:CC | GO:0140513 | nuclear protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] | 8 | 6.250533e-06 | 3 |
| GO:CC | GO:0005667 | transcription regulator complex | "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] | 5 | 5.253159e-05 | 3 |
| GO:CC | GO:0005654 | nucleoplasm | "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] | 8 | 2.548675e-04 | 3 |
| GO:CC | GO:1990234 | transferase complex | "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] | 5 | 8.076071e-04 | 3 |
| GO:CC | GO:1902494 | catalytic complex | "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] | 6 | 8.938602e-04 | 3 |
| GO:CC | GO:0140535 | intracellular protein-containing complex | "A protein-containing complex located intracellularly." [GOC:pg] | 5 | 9.768014e-04 | 3 |
| GO:CC | GO:0031981 | nuclear lumen | "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] | 8 | 2.107947e-03 | 3 |
| GO:CC | GO:0031974 | membrane-enclosed lumen | "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] | 8 | 9.597656e-03 | 3 |
| GO:CC | GO:0070013 | intracellular organelle lumen | "An organelle lumen that is part of an intracellular organelle." [GOC:mah] | 8 | 9.597656e-03 | 3 |
| GO:CC | GO:0043233 | organelle lumen | "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] | 8 | 9.597656e-03 | 3 |
| GO:CC | GO:0032991 | protein-containing complex | "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] | 8 | 3.819503e-02 | 3 |
| GO:CC | GO:0032798 | Swi5-Sfr1 complex | "A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces)." [PMID:15620352, PMID:16921379] | 1 | 4.988814e-02 | 3 |
| GO:CC | GO:0034693 | U11/U12 snRNP | "A ribonucleoprotein complex that is formed by the association of the U11 and U12 small nuclear ribonucleoproteins." [GOC:mah, PMID:15146077] | 1 | 4.988814e-02 | 3 |
| GO:CC | GO:0000112 | nucleotide-excision repair factor 3 complex | "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p)." [GOC:ew, PMID:10915862, PMID:14500720, PMID:7813015] | 1 | 4.988814e-02 | 3 |
CORUM
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| CORUM | CORUM:1036 | TFIIH transcription factor complex | TFIIH transcription factor complex | 5 | 8.244580e-11 | 3 |
| CORUM | CORUM:107 | TFIIH transcription factor complex | TFIIH transcription factor complex | 5 | 8.244580e-11 | 3 |
| CORUM | CORUM:1009 | TFIIH transcription factor complex | TFIIH transcription factor complex | 5 | 1.648102e-10 | 3 |
| CORUM | CORUM:1029 | TFIIH transcription factor complex | TFIIH transcription factor complex | 5 | 1.648102e-10 | 3 |
| CORUM | CORUM:1008 | CAK complex (Cdk-activating kinase complex) | CAK complex (Cdk-activating kinase complex) | 3 | 6.239924e-07 | 3 |
| CORUM | CORUM:1010 | CAK complex (Cdk-activating kinase complex) | CAK complex (Cdk-activating kinase complex) | 3 | 6.239924e-07 | 3 |
| CORUM | CORUM:2660 | CAK-ERCC2 complex | CAK-ERCC2 complex | 3 | 2.493754e-06 | 3 |
| CORUM | CORUM:1030 | CAK-ERCC2 complex | CAK-ERCC2 complex | 3 | 2.493754e-06 | 3 |
| CORUM | CORUM:2657 | ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex | ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex | 3 | 1.244664e-05 | 3 |
| CORUM | CORUM:1007 | CAK core complex (Cdk-activating kinase core complex) | CAK core complex (Cdk-activating kinase core complex) | 2 | 4.219436e-04 | 3 |
| CORUM | CORUM:1037 | TFIIH transcription factor core complex | TFIIH transcription factor core complex | 2 | 4.206968e-03 | 3 |
REAC
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| REAC | REAC:R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | RNA Pol II CTD phosphorylation and interaction with CE | 5 | 2.361910e-10 | 3 |
| REAC | REAC:R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 5 | 2.361910e-10 | 3 |
| REAC | REAC:R-HSA-72086 | mRNA Capping | mRNA Capping | 5 | 3.527791e-10 | 3 |
| REAC | REAC:R-HSA-73863 | RNA Polymerase I Transcription Termination | RNA Polymerase I Transcription Termination | 5 | 6.096231e-10 | 3 |
| REAC | REAC:R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | Formation of the HIV-1 Early Elongation Complex | 5 | 7.224066e-10 | 3 |
| REAC | REAC:R-HSA-113418 | Formation of the Early Elongation Complex | Formation of the Early Elongation Complex | 5 | 7.224066e-10 | 3 |
| REAC | REAC:R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | Tat-mediated elongation of the HIV-1 transcript | 5 | 3.047014e-09 | 3 |
| REAC | REAC:R-HSA-167169 | HIV Transcription Elongation | HIV Transcription Elongation | 5 | 3.047014e-09 | 3 |
| REAC | REAC:R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5 | 3.047014e-09 | 3 |
| REAC | REAC:R-HSA-5696395 | Formation of Incision Complex in GG-NER | Formation of Incision Complex in GG-NER | 5 | 3.447413e-09 | 3 |
| REAC | REAC:R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | Formation of HIV elongation complex in the absence of HIV Tat | 5 | 3.888798e-09 | 3 |
| REAC | REAC:R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | RNA Polymerase II HIV Promoter Escape | 5 | 4.906930e-09 | 3 |
| REAC | REAC:R-HSA-167161 | HIV Transcription Initiation | HIV Transcription Initiation | 5 | 4.906930e-09 | 3 |
| REAC | REAC:R-HSA-75953 | RNA Polymerase II Transcription Initiation | RNA Polymerase II Transcription Initiation | 5 | 4.906930e-09 | 3 |
| REAC | REAC:R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | RNA Polymerase II Transcription Initiation And Promoter Clearance | 5 | 4.906930e-09 | 3 |
| REAC | REAC:R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 5 | 4.906930e-09 | 3 |
| REAC | REAC:R-HSA-73776 | RNA Polymerase II Promoter Escape | RNA Polymerase II Promoter Escape | 5 | 4.906930e-09 | 3 |
| REAC | REAC:R-HSA-73762 | RNA Polymerase I Transcription Initiation | RNA Polymerase I Transcription Initiation | 5 | 5.490253e-09 | 3 |
| REAC | REAC:R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | Formation of TC-NER Pre-Incision Complex | 5 | 7.579979e-09 | 3 |
| REAC | REAC:R-HSA-112382 | Formation of RNA Pol II elongation complex | Formation of RNA Pol II elongation complex | 5 | 1.496366e-08 | 3 |
| REAC | REAC:R-HSA-75955 | RNA Polymerase II Transcription Elongation | RNA Polymerase II Transcription Elongation | 5 | 1.496366e-08 | 3 |
| REAC | REAC:R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | TP53 Regulates Transcription of DNA Repair Genes | 5 | 2.124782e-08 | 3 |
| REAC | REAC:R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | Gap-filling DNA repair synthesis and ligation in TC-NER | 5 | 2.124782e-08 | 3 |
| REAC | REAC:R-HSA-6782135 | Dual incision in TC-NER | Dual incision in TC-NER | 5 | 2.310814e-08 | 3 |
| REAC | REAC:R-HSA-212165 | Epigenetic regulation of gene expression | Epigenetic regulation of gene expression | 6 | 3.313284e-08 | 3 |
| REAC | REAC:R-HSA-167172 | Transcription of the HIV genome | Transcription of the HIV genome | 5 | 4.009033e-08 | 3 |
| REAC | REAC:R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5 | 6.151194e-08 | 3 |
| REAC | REAC:R-HSA-674695 | RNA Polymerase II Pre-transcription Events | RNA Polymerase II Pre-transcription Events | 5 | 8.561264e-08 | 3 |
| REAC | REAC:R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | Global Genome Nucleotide Excision Repair (GG-NER) | 5 | 1.098761e-07 | 3 |
| REAC | REAC:R-HSA-73772 | RNA Polymerase I Promoter Escape | RNA Polymerase I Promoter Escape | 5 | 1.562762e-07 | 3 |
| REAC | REAC:R-HSA-427413 | NoRC negatively regulates rRNA expression | NoRC negatively regulates rRNA expression | 5 | 3.425685e-07 | 3 |
| REAC | REAC:R-HSA-5696398 | Nucleotide Excision Repair | Nucleotide Excision Repair | 5 | 3.770360e-07 | 3 |
| REAC | REAC:R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | Negative epigenetic regulation of rRNA expression | 5 | 3.952784e-07 | 3 |
| REAC | REAC:R-HSA-73854 | RNA Polymerase I Promoter Clearance | RNA Polymerase I Promoter Clearance | 5 | 4.142189e-07 | 3 |
| REAC | REAC:R-HSA-73864 | RNA Polymerase I Transcription | RNA Polymerase I Transcription | 5 | 4.338774e-07 | 3 |
| REAC | REAC:R-HSA-162599 | Late Phase of HIV Life Cycle | Late Phase of HIV Life Cycle | 5 | 1.092855e-06 | 3 |
| REAC | REAC:R-HSA-162587 | HIV Life Cycle | HIV Life Cycle | 5 | 1.756645e-06 | 3 |
| REAC | REAC:R-HSA-162906 | HIV Infection | HIV Infection | 5 | 1.636457e-05 | 3 |
| REAC | REAC:R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | Cyclin A/B1/B2 associated events during G2/M transition | 3 | 9.385202e-05 | 3 |
| REAC | REAC:R-HSA-73894 | DNA Repair | DNA Repair | 5 | 1.067847e-04 | 3 |
| REAC | REAC:R-HSA-8953854 | Metabolism of RNA | Metabolism of RNA | 6 | 1.078303e-04 | 3 |
| REAC | REAC:R-HSA-3700989 | Transcriptional Regulation by TP53 | Transcriptional Regulation by TP53 | 5 | 1.648503e-04 | 3 |
| REAC | REAC:R-HSA-69231 | Cyclin D associated events in G1 | Cyclin D associated events in G1 | 3 | 5.819629e-04 | 3 |
| REAC | REAC:R-HSA-69236 | G1 Phase | G1 Phase | 3 | 5.819629e-04 | 3 |
| REAC | REAC:R-HSA-69202 | Cyclin E associated events during G1/S transition | Cyclin E associated events during G1/S transition | 3 | 3.148157e-03 | 3 |
| REAC | REAC:R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Cyclin A:Cdk2-associated events at S phase entry | 3 | 3.385329e-03 | 3 |
| REAC | REAC:R-HSA-74160 | Gene expression (Transcription) | Gene expression (Transcription) | 6 | 9.722512e-03 | 3 |
| REAC | REAC:R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3 | 1.226515e-02 | 3 |
| REAC | REAC:R-HSA-69206 | G1/S Transition | G1/S Transition | 3 | 1.284207e-02 | 3 |
| REAC | REAC:R-HSA-9824446 | Viral Infection Pathways | Viral Infection Pathways | 5 | 1.313506e-02 | 3 |
| REAC | REAC:R-HSA-453279 | Mitotic G1 phase and G1/S transition | Mitotic G1 phase and G1/S transition | 3 | 1.848137e-02 | 3 |
| REAC | REAC:R-HSA-69242 | S Phase | S Phase | 3 | 2.418750e-02 | 3 |
| REAC | REAC:R-HSA-5663205 | Infectious disease | Infectious disease | 5 | 3.400065e-02 | 3 |
| REAC | REAC:R-HSA-69275 | G2/M Transition | G2/M Transition | 3 | 4.257518e-02 | 3 |
| REAC | REAC:R-HSA-453274 | Mitotic G2-G2/M phases | Mitotic G2-G2/M phases | 3 | 4.387450e-02 | 3 |
KEGG
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| KEGG | KEGG:03022 | Basal transcription factors | Basal transcription factors | 5 | 7.709584e-10 | 3 |
| KEGG | KEGG:03420 | Nucleotide excision repair | Nucleotide excision repair | 5 | 4.756296e-09 | 3 |
WP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| WP | WP:WP405 | Eukaryotic transcription initiation | Eukaryotic transcription initiation | 5 | 4.332576e-09 | 3 |
| WP | WP:WP4753 | Nucleotide excision repair | Nucleotide excision repair | 5 | 5.563045e-09 | 3 |
| WP | WP:WP5114 | Nucleotide excision repair in xeroderma pigmentosum | Nucleotide excision repair in xeroderma pigmentosum | 5 | 9.254472e-08 | 3 |
| WP | WP:WP4946 | DNA repair pathways full network | DNA repair pathways full network | 5 | 1.040215e-06 | 3 |
| WP | WP:WP45 | G1 to S cell cycle control | G1 to S cell cycle control | 3 | 1.514818e-03 | 3 |
GO:BP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:BP | GO:0006367 | transcription initiation at RNA polymerase II promoter | "A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH] | 5 | 0.000002 | 3 |
| GO:BP | GO:0006352 | DNA-templated transcription initiation | "The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161] | 5 | 0.000005 | 3 |
| GO:BP | GO:0006351 | DNA-templated transcription | "The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH] | 8 | 0.000682 | 3 |
| GO:BP | GO:0006281 | DNA repair | "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] | 5 | 0.001198 | 3 |
| GO:BP | GO:0006289 | nucleotide-excision repair | "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] | 3 | 0.003411 | 3 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 0.003987 | 3 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] | 7 | 0.004351 | 3 |
| GO:BP | GO:0006974 | DNA damage response | "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] | 5 | 0.007772 | 3 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] | 4 | 0.011464 | 3 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] | 4 | 0.011571 | 3 |
| GO:BP | GO:0006259 | DNA metabolic process | "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] | 5 | 0.012770 | 3 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] | 4 | 0.020042 | 3 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] | 3 | 0.020223 | 3 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 7 | 0.020958 | 3 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] | 7 | 0.021770 | 3 |
| GO:BP | GO:0044770 | cell cycle phase transition | "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] | 4 | 0.027255 | 3 |
| GO:BP | GO:1902806 | regulation of cell cycle G1/S phase transition | "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] | 3 | 0.032612 | 3 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] | 7 | 0.035808 | 3 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] | 3 | 0.049185 | 3 |
GO:MF
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| GO:MF | GO:0097472 | cyclin-dependent protein kinase activity | "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] | 3 | 0.000346 | 3 |
| GO:MF | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] | 3 | 0.000346 | 3 |
| GO:MF | GO:0046966 | nuclear thyroid hormone receptor binding | "Binding to a nuclear thyroid hormone receptor." [GOC:ai] | 2 | 0.006869 | 3 |
| GO:MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] | 2 | 0.020417 | 3 |
HP
| source | term_id | annotation | description | intersection_size | p_value | community |
|---|---|---|---|---|---|---|
| HP | HP:0100012 | Neoplasm of the eye | A tumor (abnormal growth of tissue) of the eye. | 2 | 0.042597 | 3 |